Infrared, Visible Light, Ultraviolet, X-ray Or Electrical Energy Applied To Body (e.g., Iontophoresis, Etc.) Patents (Class 604/20)
-
Patent number: 8747383Abstract: A method and system for wrinkle reduction. The method includes the steps of positioning and applying a patch to skin of a consumer and adhesively securing the patch to the skin. A chemical composition on the patch includes both active ingredients and adhesive. A pair of electrodes are connected to a battery-driven, microprocessor-based controller. A current is applied through the electrodes in the patch for a selected time. The chemical composition in the patch is propelled into the consumer through use of the current in order to relax the skin of the consumer. The patch is removed and any residue of the chemical composition is massaged into the skin.Type: GrantFiled: December 16, 2010Date of Patent: June 10, 2014Assignee: University Medical Pharmaceuticals Corp.Inventors: Ray Francis, John Trengove, Greg Hunt, Josh Hoyt, Jim Thorne, Darrick Carter
-
Patent number: 8747384Abstract: Antibiotics are administered in a surgical site subcutaneously via a small or stab incision in the surgical field. Transcutaneous ultrasonic vibrations are applied across the surgical field, which is then opened in the usual manner, to thereby provide a surgical field which contains a vastly higher and more effective level of antibiotic. At the same time the underlying tissue is hydrated.Type: GrantFiled: August 8, 2011Date of Patent: June 10, 2014Inventor: Barry Neil Silberg
-
Patent number: 8747389Abstract: Devices, systems and methods useable for dilating the ostia of paranasal sinuses and/or other passageways within the ear, nose or throat. A dilation catheter device and system is constructed in a manner that facilitates ease of use by the operator and, in at least some cases, allows the dilation procedure to be performed by a single operator. Additionally, the dilation catheter device and system may be useable in conjunction with an endoscope and/or a fluoroscope to provide for easy manipulation and positioning of the devices and real time visualization of the entire procedure or selected portions thereof. In some embodiments, an optional handle may be used to facilitate grasping or supporting a device of the present invention as well as another device (e.g., an endoscope) with a single hand.Type: GrantFiled: April 24, 2007Date of Patent: June 10, 2014Assignee: Acclarent, Inc.Inventors: Eric Goldfarb, John Y. Chang, William M. Facteau, Sivette Lam, Hung V. Ha, Isaac J. Kim, Ketan P. Muni
-
Patent number: 8748446Abstract: Halo-organic heterocyclic compounds are described, which have the formulas Ring A is an aromatic ring bound to at least two halogen atoms, at least one of which is iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.Type: GrantFiled: March 3, 2012Date of Patent: June 10, 2014Assignee: Nanoquantum Sciences, Inc.Inventors: Gary W. Jones, Anatoliy L. Tatarets, Leonid D. Patsenker
-
Publication number: 20140155679Abstract: Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.Type: ApplicationFiled: October 29, 2013Publication date: June 5, 2014Applicant: INSULINE MEDICAL LTD.Inventors: Benny Pesach, Gabriel Bitton, Ron Nagar, Ram Weiss
-
Publication number: 20140155811Abstract: An implantable electrode array assembly configured to stimulate tissue of a recipient, including an elongate member configured to be inserted into a recipient, wherein at least a portion of the elongate member includes a bio-active substance.Type: ApplicationFiled: November 29, 2013Publication date: June 5, 2014Inventor: Peter Gibson
-
Publication number: 20140155812Abstract: A method of removing at least one hair from a mammal comprising the steps of associating electromagnetic responsive species to the root of at least one hair and exposing the electromagnetic responsive species to an oscillating electromagnetic field.Type: ApplicationFiled: July 18, 2011Publication date: June 5, 2014Applicant: SCIENTIFIC-WIZARD LTD.Inventor: Yair Lauber
-
Publication number: 20140155678Abstract: An approach combining immune-based therapies with focused radiation, including stereotactic radiation, to treat cancers is disclosed. The use of focused radiation primes the immune system in a similar manner to vaccines to augment immune-based therapies and can counteract the suppressive effects of a tumor. The combination of focused radiation and immune-based therapies, including administration of at least one immunotherapeutic agent, improves survival compared to each therapy alone and can, in some cases, lead to a durable cure. Accordingly, focused radiation can be an adjuvant for immune-based therapies for treating cancers.Type: ApplicationFiled: June 19, 2012Publication date: June 5, 2014Inventors: Jing Zeng, Charles George Drake, Drew M. Pardoll, Michael Lim
-
Publication number: 20140155680Abstract: Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.Type: ApplicationFiled: February 4, 2014Publication date: June 5, 2014Applicant: Biomet Biologics, LLCInventors: Joel C. HIGGINS, Bruce SIMON, Jennifer E. WOODELL-MAY
-
Publication number: 20140155362Abstract: Embodiments of the present disclosure provide for BHQ-conjugates and protected BHQ-conjugate precursor compounds, methods of making BHQ-conjugates and protected BHQ-conjugate precursor compounds, methods of using BHQ-conjugates and protected BHQ-conjugate precursor compounds, and the like.Type: ApplicationFiled: June 28, 2012Publication date: June 5, 2014Inventors: Timothy M. Dore, James D. Lauderdale, Adam C. Rea, Adna Muliawan, Duncan McLain
-
Publication number: 20140154186Abstract: Compound of Formula I: are described, along with compositions containing the same and methods of use thereof.Type: ApplicationFiled: May 30, 2012Publication date: June 5, 2014Applicant: North Caroliina State UniversityInventors: Jonathan S. Lindsey, Michael Krayer
-
Patent number: 8744568Abstract: Medical devices comprising an electroactive polymer powered by a photovoltaic cell. In one embodiment, the medical device has an electroactive component comprising an electroactive polymer. The medical device further comprises a photovoltaic cell as a source of electrical power for electrically stimulating the electroactive polymer. The medical device further comprises a first electrode and a second electrode, both of which are electrically connected to the photovoltaic cell. The electroactive component covers over at least a portion of the first electrode. Also disclosed is a method of treating a patient using a medical device having an electroactive polymer powered by a photovoltaic cell.Type: GrantFiled: November 24, 2010Date of Patent: June 3, 2014Assignee: Boston Scientific Scimed, Inc.Inventor: Jan Weber
-
Patent number: 8744569Abstract: An embodiment of a system includes a power source and at least two electrode assembles. The power source that an output current that alternates between a maximum current value and a minimum current value; a pair of electrode assemblies. Each electrode assembly is configured to be held in contact with a skin layer of a user. Additionally, each electrode assembly includes an electrode that is coupled to the power source to receive the output current from the power source. At least one of the electrode assemblies in the pair includes a medium that carries an active agent having a charge, the medium being provided on the at least one electrode assembly to enable the output current to repel the active agent into the skin layer for a duration in which the output current has a polarity that is the same as a polarity of the active agent.Type: GrantFiled: May 25, 2012Date of Patent: June 3, 2014Assignee: InCube Labs, LLCInventor: Mir Imran
-
Patent number: 8744567Abstract: A galvanic device for treatment of skin is provided. The device comprises a substrate comprising a plurality of discrete galvanic couples, each galvanic couple comprising a first conductive electrode that is an anode in electronic communication with a second conductive electrode that is a cathode.Type: GrantFiled: November 8, 2010Date of Patent: June 3, 2014Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Ali Fassih, Ronald J. Gillespie, Jue-Chen Liu, Chong Jin Loy, Claude Saliou, Ying Sun
-
Publication number: 20140148735Abstract: Methods, systems, and devices are described for treating ischemia in heart tissue after a heart attack. A method includes providing a heat treatment device comprising a heating element, positioning the heating element in proximity to the heart tissue, and heating the heart tissue with the heating element to generate release of heat shock proteins in the heart tissue. The heat shock proteins may also be provided via delivery of a drug. The heat shock proteins can provide myocardial protection for the heart tissue.Type: ApplicationFiled: October 15, 2013Publication date: May 29, 2014Applicant: COVIDIEN LPInventor: WILLIAM H. NAU, JR.
-
Patent number: 8734316Abstract: This invention relates to an apparatus that regulates thermodynamic energy-flow within a human body for producing beneficial effects such as, for example, improvement in strength, improvement in stamina, pain relief, etc. According to one embodiment, the invention provides a wearable apparatus that may include biomolecular components for building-up of a thermomagnetic energy within the human body. According to another embodiment, the invention provides a wearable apparatus that may include biomolecular components for dilution of a thermomagnetic energy within the human body. According to yet another embodiment, the invention provides a wearable apparatus that may include biomolecular components having orthomolecular and/or non-orthomolecular organic materials which are capable of thermomagnetic levororotary action and/or thermomagnetic dextrorotatory action.Type: GrantFiled: October 29, 2010Date of Patent: May 27, 2014Assignee: LifeWave, Inc.Inventor: David Schmidt
-
Patent number: 8738485Abstract: Transaction processing in an offline environment for a prepaid product comprising a portable consumer device includes responding to presentation of the prepaid product at a reader for offline processing by initiating operation of the prepaid product, receiving data from the prepaid product at the reader that indicates the prepaid product is associated with a prepaid account balance, determining that the prepaid product is in a negative balance condition, and taking preventive action in response to the negative balance condition such that future acceptance of the prepaid product at a reader is prevented.Type: GrantFiled: December 28, 2007Date of Patent: May 27, 2014Assignee: Visa U.S.A. Inc.Inventors: Philip B. Dixon, Ayman Hammad, Khalid El-Awady
-
Patent number: 8731655Abstract: The invention relates generally to optical agents for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising compounds with an acyclic N—N bond having at least one aromatic and/or heterocyclic aromatic group providing phototherapeutic agents, including Type 1 phototherapeutic agents. In some embodiments, for example, the invention provides compounds for phototherapeutic methods having one or more photolabile acyclic N—N bonds capable of undergoing photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.Type: GrantFiled: May 12, 2010Date of Patent: May 20, 2014Assignee: Mallinckrodt LLCInventor: Raghavan Rajagopalan
-
Publication number: 20140135679Abstract: A system is provided for testing whether an iontophoretic drug delivery device is in an appropriate state for administering a therapeutic agent into an animal body. An electrical characteristic of at least one electrical path associated with an electrode test point is used to determine whether the iontophoretic device is in an appropriate state. The measured electrical characteristic indicates that the iontophoretic device is in an appropriate state for administering the therapeutic agent into the animal body when the therapeutic agent is properly disposed with respect to the electrodes of the iontophoretic device.Type: ApplicationFiled: November 14, 2012Publication date: May 15, 2014Applicant: NUPATHE, INC.Inventors: Ronalee Lo Mann, Jason Clevenger, David Saar
-
Publication number: 20140135680Abstract: Methods and compositions to controllably regulate cells at a target site. A quantum dot-targeting agent complex is administered to a patient in need of therapy, and the complex is stimulated using an implanted fiber optic system. In embodiments, the system includes an electrical sensor that detects and monitors electrical activity of the stimulated controllably regulated cells, and relays this information to a controller that can regulate further stimulation.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Inventor: Gholam A. Peyman
-
Publication number: 20140128799Abstract: It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.Type: ApplicationFiled: June 20, 2012Publication date: May 8, 2014Inventors: Tohru Tanaka, Katsushi Inoue, Takuya Ishii, Tokato Yoshida
-
Publication number: 20140128800Abstract: Provided herein is a chimeric photoactivatable polypeptide comprising an opsin membrane receptor, wherein an intracellular domain of the opsin membrane receptor is replaced with a corresponding intracellular domain of a chemokine receptor, a sphingosine-1-phosphate receptor or an ATP receptor and uses thereof. Further provided are methods of treating cancer, injury of the nervous system, autoimmune disease, and graft rejection comprising administering to the subject a cell that expresses the chimeric photoactivatable polypeptide and exposing the cell to a visible light source.Type: ApplicationFiled: June 28, 2012Publication date: May 8, 2014Applicant: UNIVERSITY OF ROCHESTERInventor: Minsoo Kim
-
Publication number: 20140127077Abstract: A device for decontaminating a medical device, the device including a compartment adapted to contain a medical device and a solution, the solution comprising a photoactivatable substance; and a light system providing 360 degrees of exposure to the compartment. Also, a method for decontaminating a medical device, the method including placing a medical device in a compartment with a solution, the solution comprising a photoactivatable substance; incubating the medical device in the solution to allow the photoactivatable substance to attach to pathogens; and exposing the compartment to 360 degrees of light exposure to activate the photoactivatable substance.Type: ApplicationFiled: March 15, 2013Publication date: May 8, 2014Inventor: GAIL ROCK
-
Publication number: 20140128780Abstract: A skin treatment device includes a body having a treatment head at one end and a dispenser head at another end. The treatment head includes a potting containing at least one light source for emitting electromagnetic radiation having desired characteristics for treating one or more skin conditions. A skin contacting surface is disposed at one end of the potting and is adapted for transmitting electromagnetic radiation emitted from the light source to a user's skin. A vibrator is directly or indirectly in contact with the other end of the potting for causing the skin contacting surface to vibrate. The dispenser head includes a dispensing assembly for dispensing a desired substance for use in treating one or more skin conditions.Type: ApplicationFiled: March 27, 2012Publication date: May 8, 2014Applicant: SYNERON BEAUTY LTDInventors: John Kennedy, Jinxin Yu
-
Publication number: 20140128836Abstract: Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.Type: ApplicationFiled: January 15, 2014Publication date: May 8, 2014Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITEDInventors: Abraham J. DOMB, Joseph FRUCHT-PERY, Mervyn SHAPIRO
-
Publication number: 20140128798Abstract: The invention relates generally to intradermal, transdermal, and/or transmembrane delivery of biologically active substances in the epidermis and/or through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The biologically active substances may have a molecular weight no less than about 5.8 kDa to about 2,500 kDa, such as Hyaluronic Acid (HA). The biologically active substances may be deposited in a dermal patch containing a red algae polysaccharide-based matrix, wherein the red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch. The invention provides systems and methods for enhanced intradermal, transdermal, and/or transmembrane delivery of such biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.Type: ApplicationFiled: May 20, 2011Publication date: May 8, 2014Applicants: PHOTOKINETIX HOLDINGS INC., PRINCIPIUM EUROPE S.R.L.Inventors: Julien Janson, Edward R. Kraft, Gabriela Kulp, Rosella Malanchin
-
Publication number: 20140128797Abstract: Enzyme-activatable photosensitizing polymer conjugates are disclosed for photochemotherapeutic treatment of human diseases and disorders, bacteriologic or virologic indications, cosmetic applications and other pathologic situations. These polymer conjugates may comprise a polymer carrier, a photosensitizer, a quencher, a targeting molecule and/or a biocompatibilizing unit. These macromolecular conjugates may be designed to guide to the target tissue a photosensitizing agent in an inactive, non-phototoxic form. However, upon entering the target environment, in which certain enzymes are presently active, the conjugate may release its photosensitizers in its fully active form, resulting in a highly localized activation of the photoactive agent. Also described here are methods, compositions and kits for the preparation and testing of such photochemotherapeutic conjugates.Type: ApplicationFiled: April 10, 2013Publication date: May 8, 2014Inventors: Norbert LANGE, Marino A. CAMPO
-
Patent number: 8718754Abstract: Transnasal delivery of medication directly to a patient's brain is achieved using an iontophoresis wire cooperable with a medication administration device. A controller regulates an electric charge to the iontophoresis wire. The iontophoresis wire is insertable into each nasal cavity. This wire is preferably encased in a tube, through which the medication will be transnasally delivered. A cleaning solution may also be delivered to the nasal cavity after treatment to reduce irritation from the iontophoresis.Type: GrantFiled: May 14, 2010Date of Patent: May 6, 2014Inventor: Eduard N. Lerner
-
Publication number: 20140120167Abstract: Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation-therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (GNPs), near-infrared short laser pulses, and X-rays.Type: ApplicationFiled: October 30, 2013Publication date: May 1, 2014Applicant: WILLIAM MARSH RICE UNIVERSITYInventors: Dmitri Lapotko, Katsiaryna Hleb, Michael E. Kupferman, Daniel Scudder Wagner, Vladimir Torchilin, Xiangwei Wu
-
Patent number: 8709449Abstract: The present invention provides methods and compositions for increasing the effectiveness of photodynamic therapy (“PDT”) and for reducing the duration of skin phototoxicity associated with PDT treatment. The disclosed methods generally include the administration of a lipid composition before, during, or after the administration of photosensitizers used in the PDT treatment protocol. The lipids are preferably phospholipids. It was discovered that the disclosed methods resulted in a more rapid clearance of photosensitizers from the skin and other tissue of patients, which results in a shorter period of skin phototoxicity after PDT treatment. The present invention also provides a composition which is preferably comprised of non-polar photosensitizers and phospholipids.Type: GrantFiled: February 10, 2005Date of Patent: April 29, 2014Assignee: Biolitec Pharma Marketing LtdInventors: Volker Albrecht, Susanna Gräfe
-
Publication number: 20140114231Abstract: This patent discloses formulations, compositions, and process method and device, of hydrophobic extracts and biomass of Skin Tree, also called Mimosa tenuiflora, also called Mimosa cabrera, also called Mimosa hostilis, also called Jurema, also called Tepezcohuite, and apparatus used for cell repair, and the regeneration and rejuvenation of glabrous skin and hair bearing skin. The formulations and compositions herein disclosed, alone and when used with apparatus described, i.e. in combination, will serve to modulate cell repair and block inflammatory processes, infection and disease, reversing skin aging, thereby restoring normal cell and skin conditions, coloration, homeostasis, youth, vitality, and firmness.Type: ApplicationFiled: October 20, 2012Publication date: April 24, 2014Inventors: Bertha Rostro, Mehdie Kohanloo, Dana Johnson, Candace Johnson
-
Publication number: 20140114233Abstract: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Applicant: The Foundry, LLCInventors: Mark E. Deem, Hanson Gifford
-
Publication number: 20140114215Abstract: Methods for treating preventing or decreasing the likelihood of a human patient developing hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension or prehypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal nerves.Type: ApplicationFiled: March 15, 2013Publication date: April 24, 2014Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventors: Robert J. Melder, Stefan S. Tunev
-
Publication number: 20140114232Abstract: An apparatus for the treatment and/or prevention of corneal diseases includes an applicator head. The applicator head includes a radiation source capable of exciting a non-toxic chromophore. A control is operable to activate the radiation source to radiate, wherein at least one of the following two conditions is met: the applicator head includes a sensor capable of measuring a signal dependent on a position of the applicator head relative to the cornea; or, the applicator head is configured to be in physical contact with the cornea. The control is operable to activate the radiation source to radiate depending on a signal measured by the sensor or to activate the radiation source when the applicator head touches the cornea, respectively.Type: ApplicationFiled: April 23, 2012Publication date: April 24, 2014Applicants: UNIVERSITE DE GENEVE, HOPITAUX UNIVERSITAIRES DE GENEVEInventors: Farhad Hafezi, Olivier Richoz
-
Patent number: 8706210Abstract: The invention provides for a device for delivering a drug comprising: a. forming one or more micropores in a tissue membrane; and b. applying a patch containing a drug to the one or more micropores formed in the tissue membrane The invention also provides for methods of making and methods of using the same.Type: GrantFiled: January 27, 2009Date of Patent: April 22, 2014Assignee: Nitto Denko CorporationInventors: Jonathan Eppstein, Stuart McRae
-
Patent number: 8706211Abstract: Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.Type: GrantFiled: November 10, 2010Date of Patent: April 22, 2014Inventors: Ralph G. Dacey, Jr., Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Nathan P. Myhrvold, Dennis J. Rivet, Michael A. Smith, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
-
Publication number: 20140107559Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.Type: ApplicationFiled: May 21, 2013Publication date: April 17, 2014Inventor: Pierre Roy
-
Publication number: 20140105834Abstract: A method for non-surgical rejuvenation of facial skin to correct both Type 1 aging changes in the epidermis layer of the skin causing visual changes in the skin and Type 2 aging changes in the dermis layer of the skin causing damage to supportive elements of the skin. The method includes the steps of exfoliation of the facial skin, stimulation of new dermal collagen deposition, removal of at least one of pigment and superficial blood vessels, relaxation of facial expression muscles, filling of soft tissue defects including at least one of deep facial lines and contour deformities, and tightening of the facial skin, and the steps of the method are applied according to a selected one of a plurality of age determined regimens.Type: ApplicationFiled: October 16, 2012Publication date: April 17, 2014Inventor: Brooke R. Seckel
-
Publication number: 20140100514Abstract: An implantable component of a medical device, comprising a polymeric surface. The component includes one or more macro-surface features at the polymeric surface having a configuration that, following application of a liquid drug to the surface retains a quantity of the liquid drug adjacent the surface.Type: ApplicationFiled: August 5, 2013Publication date: April 10, 2014Inventors: Edmond Capcelea, Fysh Dadd, Kristien J. M. Verhoeven
-
Patent number: 8690818Abstract: The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.Type: GrantFiled: December 21, 2011Date of Patent: April 8, 2014Assignee: Ekos CorporationInventors: Frederick J. Bennett, John Zhang, Gary Lichttenegger, James E. Rodriguey, Katsuro Tachibana
-
Patent number: 8691268Abstract: A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.Type: GrantFiled: September 15, 2010Date of Patent: April 8, 2014Assignee: Ultra-Sonic Technologies, L.L.C.Inventor: Ludwig J. Weimann
-
Patent number: 8690865Abstract: The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.Type: GrantFiled: May 31, 2005Date of Patent: April 8, 2014Assignee: Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Mark G. Allen, Jung-Hwan Park, Yong-Kyu Yoon, Jin-Woo Park
-
Patent number: 8685466Abstract: The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.Type: GrantFiled: July 19, 2010Date of Patent: April 1, 2014Assignee: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis
-
Publication number: 20140088488Abstract: Lysing of fat cells in adipose tissue beneath the skin and liquefying the released fat is achieved by introducing a side-firing thermal energy device into the tissue to be irradiated, while thermal energy, such as laser energy, is emitted at a selected level for a selected period of time, depending on the volume to tissue to be irradiated. The side firing device is advanced into tissue and withdrawn and, while energy is emitted, is aimed separately at 3 o'clock and 9 o'clock and, is repetitively rotated through an arc of about 120°, producing a bowtie-shaped irradiation pattern. The side firing device may be centered and sealingly held in position in a liposuction cannula by ribs extending inwardly from the interior of the liposuction cannula. At least one of the ribs has a channel for infusion of an irrigating liquid.Type: ApplicationFiled: September 27, 2013Publication date: March 27, 2014Inventor: Marvin P. Loeb
-
Publication number: 20140088489Abstract: The invention is applicable to the field of medical care products, and provides a wound care apparatus. The wound care apparatus comprises a pump and a sealed dressing connected to the pump via a first pipeline, a laser being disposed at the upper end of the sealed dressing. The wound care apparatus further comprises a pus bottle that is connected with a piece of sponge and the pump via rubber hoses, respectively. In the invention, the pump of the wound care apparatus is connected with the sealed dressing via the first pipeline, after the wound is dressed by the sealed dressing, the pump is controlled to pump the wounded area into a vacuum state, and ulceration caused by airborne bacterial infection is thus prevented. More importantly, the wound healing rate under a near-negative pressure environment is two to three times of that under normal environment.Type: ApplicationFiled: September 9, 2011Publication date: March 27, 2014Inventor: Yaolin Li
-
Publication number: 20140086867Abstract: A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target location on the scalp of the subject to induce an inciting event at the target scalp location, and (iii) administering a therapeutically effective amount of said ECM composition to the target scalp location. In some embodiments, the ECM composition includes at least one additional biologically active agent.Type: ApplicationFiled: September 19, 2013Publication date: March 27, 2014Inventor: Robert G. Matheny
-
Publication number: 20140088487Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.Type: ApplicationFiled: December 21, 2011Publication date: March 27, 2014Applicant: ETHICON ENDO-SURGERY, INC.Inventors: Jason L. Harris, Lee M. Kaplan, David N. Plescia, Taylor W. Aronhalt, James W. Voegele, Nicholas Stylopoulos
-
Publication number: 20140088486Abstract: Devices and methods are provided for drug delivery. The device may include a housing having a first compartment containing a drug in a dry, solid form, a second compartment containing a liquid carrier for the drug, and an expansion member located within or adjacent to the first or second compartment. The second compartment may be fluidly connectable to the first compartment by a rupturable barrier or mechanical valve. The device may also include an actuation system configured to expand the expansion member to rupture the rupturable barrier or open the mechanical valve and permit the liquid carrier to flow into the first compartment and mix with the drug to form a reconstituted drug solution.Type: ApplicationFiled: September 27, 2012Publication date: March 27, 2014Applicant: PALO ALTO RESEARCH CENTER INCORPORATEDInventors: Scott A. Uhland, Felicia Linn, Michael I. Recht
-
Publication number: 20140074009Abstract: The invention provides a method for generation of a singlet oxygen comprising the following steps: irradiating with light on a metal nanoparticle at a specific wavelength; and transmitting a photon energy to sensitize a molecular oxygen to generate the singlet oxygen; wherein, the amount of the singlet oxygen is dependent on the wavelength of excitation light and aspect ratio of the metal nanoparticle.Type: ApplicationFiled: September 13, 2012Publication date: March 13, 2014Inventors: Kuo-Chu HWANG, Raviraj Vankayala
-
Publication number: 20140074010Abstract: A wearable apparatus (100) for directing electromagnetic radiation onto at least one tissue area is disclosed. The apparatus comprises at least one radiation collection surface (101) for receiving incident electromagnetic radiation and at least one radiation emitting surface (102) adapted to direct electromagnetic radiation onto at least one target area of tissue to be treated. A light guide (103) is adapted to receive electromagnetic radiation received by at least one radiation collection surface and to direct at least part of the electromagnetic radiation to at least one radiation emitting surface, wherein a total surface area of the or each radiation collection surface is larger than a total surface area of the or each radiation emitting surface. Coupling means increases the proportion of electromagnetic radiation received by at least one radiation collection surface which enters the light guide.Type: ApplicationFiled: August 11, 2011Publication date: March 13, 2014Applicant: POLYPHOTONIX LIMITEDInventors: Janos Veres, Christophe Olivier Miremont, Duncan John Hill