With Tubular Injection Means Inserted Into Body Patents (Class 604/21)
  • Patent number: 11471595
    Abstract: A system for infusing medication into a mammalian subject is provided. The system includes an injection system for controlling a flow of fluid from a fluid reservoir to a needle. A sensor is provided that detects a characteristic indicative of the fluid pressure in the needle. The injection system controls the flow of fluid to the needle in response to the characteristic detected by the sensor and the sensor continuously detects the characteristic as the needle is inserted into the subject. The system further includes a conductive element for providing electric nerve stimulation, wherein the system provides electric nerve stimulation in response to the sensor detecting a pressure exceeding an upper limit.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 18, 2022
    Inventors: Mark N. Hochman, Olivier Choquet
  • Patent number: 11464955
    Abstract: A dermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 11, 2022
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Marc Alary, Bharat Patel, Peyton Hopson, Jan-Joo Liu, Vipul Davé
  • Patent number: 11453873
    Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: September 27, 2022
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl, John L. Robertson, Robert E. Neal, II
  • Patent number: 11413440
    Abstract: A transdermal delivery device includes a film having first and second outwardly facing major surfaces; at least one liquid reservoir contained within the film; at least one microfluidic channel having a transverse dimension between about 100 nm and 0.5 mm disposed within the film and in fluid communication with the at least one liquid reservoir; and at least one outlet port associated with at least one microneedle operatively connected to the first outwardly facing major surface of the film in fluid communication with the at least one microfluidic channel.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 16, 2022
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Marc Alary, Bharat Patel, Peyton Hopson, Jan-Joo Liu, Vipul Davé
  • Patent number: 11389531
    Abstract: Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: July 19, 2022
    Assignees: Janssen Sciences Ireland Unlimited Company, Ichor Medical Systems, Inc.
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy, Andrew W. Hannaman, Robert M. Bernard, Stephen A. Morse, Oliver Ruck, Adam Hartman, Thomas David Cox, Dorien De Pooter
  • Patent number: 11331479
    Abstract: Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single hypodermic injection needle and at least two spaced elongate electrodes which provide for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: May 17, 2022
    Assignee: Inovio Pharmaceuticals, Inc.
    Inventors: Rune Kjeken, Iacob Mathiesen, Elisabeth Torunn Tjelle, George McHugh
  • Patent number: 11305071
    Abstract: Some embodiments are directed to a needle assembly including at least N injection needles where N is at least four and a multiple of two. The needle assembly also includes a first liquid port adapted to be connected to an injection device, and N second liquid ports connected to one of the N injection needles. N/2 main liquid pathways each have an entrance connected to the first liquid port and an exit, further including N/2 secondary liquid pathways that have two extremities each opening on one of the N second liquid ports, and a mid portion connected to the exit of one of the main liquid pathways. The main liquid pathways and the secondary liquid pathways define N liquid flow paths between the first liquid port and the N second liquid ports dimensioned so a pressure drop between them is similar.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: April 19, 2022
    Assignee: TERUMO EUROPE N.V.
    Inventors: Pieter Casteleyn, Ludo Daniels, Veerle Royen, Christian Fripon
  • Patent number: 11224733
    Abstract: A suction/irrigation medical device valve system comprises a first valve plunger configured for insertion into a first valve plunger channel. The first valve plunger has a first latch member disposed at a distal end with a first sealing member and a first valve opening disposed proximally from the first latch member. The system also comprises a second valve plunger configured for insertion into a second valve plunger channel. The second valve plunger includes a second valve opening that is longer than the first valve opening. The system also comprises a valve body having the first and second valve plunger channels. The first and second valve plunger channels are configured to receive the first and second valve plungers, respectively.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 18, 2022
    Inventors: Edward P. Donlon, Craig Tsuji
  • Patent number: 11213671
    Abstract: Embodiments of the present invention provide an electroporation system comprising an electroporation probe having at least two contiguous electrodes configured to be inserted into biological tissue for electroporation treatment, and a pulse generator electrically connected to the probe and configured to drive the electroporation probe using a sequence of one or more electric pulses to cause current transmission through the probe and induce a non-uniform electric field in the biological tissue proximate the probe electrodes. Treatment tissue can be targeted by controlling the probe configuration, carrier solution characteristics and parameters of the electroporation pulse sequence to achieve predictable electroporation outcomes. This electroporation control method can also reduce potentially toxic effects of electroporation treatment.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 4, 2022
    Assignee: NewSouth Innovations Pty Limited
    Inventors: Gary David Housley, Nigel Hamilton Lovell, Jeremy Pinyon, Edward Norman Crawford, Cherylea Browne
  • Patent number: 11213663
    Abstract: Disclosed is a microneedle including at least one tip portion that is capable of penetrating the skin and includes a liquid medicine melted in the skin; a base portion supporting the at least one tip portion; and at least one guide portion that is provided between the at least one tip portion and the base portion, is made of a non-soluble material, and is protruded in a direction in which the at least one tip portion penetrates the skin to couple with the at least one tip portion. In accordance with such a configuration, the at least one tip portion may be instantly separated in a short time, whereby superior liquid medicine supplyability is exhibited.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: January 4, 2022
    Assignee: QuadMedicine
    Inventors: Seung Ki Baek, Myun Hwan Ahn
  • Patent number: 11179582
    Abstract: An ultrasonic surgical instrument is disclosed including a handle including a pivoting handle portion, an end effector configured to treat tissue, a waveguide extending to the end effector, a battery and a vibration generating system selectively operable in a plurality of energizing operating states. The plurality of energizing operating states consists of a first operating state in which a first power is supplied to the end effector and a second operating state in which a second power is supplied to the end effector. The first power is different than the second power. The vibration generating system includes a transducer selectively attachable to the handle and a switch configured to operably switch the vibration generating system between the first operating state and the second operating state. The switch is further configured to operably switch the vibration generating system between the plurality of energizing operating states and a non-energizing operating state.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: November 23, 2021
    Assignee: Cilag GmbH International
    Inventors: Aaron C. Voegele, Scott A. Nield, Foster B. Stulen, Shan Wan
  • Patent number: 11160964
    Abstract: An apparatus for manufacturing a multilayer microneedle patch and a method to manufacture a multilayer microneedle patch is disclosed along with multilayer microneedle patches.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: November 2, 2021
    Assignee: Microneedles Inc.
    Inventors: Vasilii Nikolaevich Zvezdin, Ivan Arkadevich Kasatkin, Tatiana Igorevna Akafeva, Andrei Jurievich Pavlov, Iurii Alexandrovich Silov
  • Patent number: 11141217
    Abstract: According to the invention, there is provided a probe applicator (10) disposed for receiving flexible probes (11) that are intended for endoscopic use and can be made accessible with the probe applicator for laparoscopic use. The control of the device supplying the probes (11) occurs via control elements (32, 33) of the probe applicator (10). Preferably, the probe (11) is supplied via a connecting device (38) provided on the probe applicator (10).
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 12, 2021
    Assignee: Erbe Elektromedizin GmbH
    Inventor: Thorsten Rombach
  • Patent number: 11135364
    Abstract: Systems and methods are disclosed herein for monitoring the status of an ambulatory medical device and the health condition of a subject that receives therapy from the ambulatory medical device. The ambulatory medical device can have a touchscreen display user interface to receive input signals from a user and display alarm conditions associated with the status of an ambulatory medical device or health condition of a subject. The disclosed methods and systems can determine whether status information received from a monitoring system interface satisfies an alarm condition for the ambulatory medicament device or for the subject. If the status information satisfies an alarm condition, the touchscreen user interface can display one or more alarm status indicators corresponding to the alarm condition. The user can activate a therapy change interface on the touchscreen display and modify a control parameter of the ambulatory medical device that controls the therapy delivery to the subject.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: October 5, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Michael J. Rosinko, Edward R. Damiano, David Chi-Wai Lim, Firas H. El-Khatib, Justin P. Brown, Bryan Dale Knodel
  • Patent number: 11123498
    Abstract: The present invention relates to a treatment device and a method for controlling the same, and provides a treatment device comprising: an insertion unit formed to be insertable in tissue after penetrating through a surface of the tissue; a displacement measuring unit for measuring displacement of the surface of the tissue, caused by an insertion of the insertion unit; and a control unit for controlling an insertion motion of the insertion unit on the basis of the displacement measured by the displacement measuring unit. According to the present invention, the device allows medical treatment in a state in which the insertion unit has been inserted to reach a precise position of a target, so as to improve an effect of medical treatment.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 21, 2021
    Inventor: Kwang Chon Ko
  • Patent number: 11096713
    Abstract: Disclosed is a skin treatment device, including: a support main body; a rotating part mounted on one surface of the support main body to be rotatable about a rotating shaft; a plurality of elastic parts which have one ends fixed to the support main body and inserted into the rotating part and are disposed to correspond to a rotation direction of the rotating part, and a needle holder coupled to tip ends of the elastic parts. When the rotating part rotates, the plurality of elastic parts are bent in the rotation direction so that relative positions of tip ends of the elastic parts vary.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 24, 2021
    Assignee: AGNES MEDICAL CO., LTD.
    Inventor: Gunyoung Ahn
  • Patent number: 11090122
    Abstract: A surgical robotic system has a tool drive coupled to a distal end of a robotic arm that has a plurality of actuators. The tool drive has a docking interface to receive a trocar. One or more sensors in the docking interface sense a magnetic field generated by the trocar. One or more processors are configured to determine a position and orientation of the trocar based on the sensed magnetic field, and then drive the actuators to orient the docking interface to the determined orientation of the trocar, or otherwise guide the robotic arm toward the determined position of the trocar. Other aspects are also described and claimed.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: August 17, 2021
    Assignee: VERB SURGICAL INC.
    Inventors: Bernhard A. Fuerst, Dennis Moses, Miguel Piedrahita, Michael Wong, Pablo Garcia Kilroy, Jose Luis Cordoba
  • Patent number: 11077317
    Abstract: A method has been invented for intravenously inserting a tumor reduction radiation emitter into the body of a patient suffering from a cancerous tumor. The emitter is very small, yet detectable by medical imaging techniques and guidable by use of magnetism. The emitter is guided through the body by use of a magnet until it is adjacent or in in the tumor itself. The emitter can be oriented in various desired directions by the magnet. The emitter is then wirelessly powered by electrical induction, causing the radiation of a desired wavelength to be directed to tumor cells, causing tumor reduction.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 3, 2021
    Inventor: Warren Z McCarthy
  • Patent number: 11065428
    Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: July 20, 2021
    Assignee: Allergan, Inc.
    Inventors: Futian Liu, Xiaojie Yu, Lance E. Steward, Guang Wei Lu, Patrick M. Hughes, Sheshadri Neervannan
  • Patent number: 11052267
    Abstract: An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: July 6, 2021
    Inventors: Chris J. Diederich, Jeffrey C. Lotz, Will Nau, David S. Bradford
  • Patent number: 11045614
    Abstract: Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: June 29, 2021
    Assignee: TUSKER MEDICAL, INC.
    Inventors: Bernard H. Andreas, Mansour Saleki, Rohit Girotra, Alfredo Cantu, Nikhil Bhat
  • Patent number: 11007365
    Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: May 18, 2021
    Inventors: Paul Goldfarb, Dietmar Rabussay
  • Patent number: 11000707
    Abstract: In one general aspect, various embodiments are directed to an ultrasonic surgical instrument that comprises a transducer configured to produce vibrations along a longitudinal axis at a predetermined frequency. In various embodiments, an ultrasonic blade extends along the longitudinal axis and is coupled to the transducer. In various embodiments, the ultrasonic blade includes a body having a proximal end and a distal end, wherein the distal end is movable relative to the longitudinal axis by the vibrations produced by the transducer.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 11, 2021
    Assignee: Ethicon LLC
    Inventors: Aaron C. Voegele, Scott A. Nield, Shan Wan
  • Patent number: 10967165
    Abstract: Embodiments of the invention include methods of tissue/wound treatment and associated devices and systems, including devices for breaching bio-films contained in and around wounds, devices for maximizing moisture vapor transmission rate, and tissue dressings with added barrier features for permeable surfaces.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: April 6, 2021
    Assignee: Oxyband Technologies Inc
    Inventor: Coni F Rosati
  • Patent number: 10952790
    Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable balloon may be coupled to the catheter shaft. The balloon may be capable of shifting between a folded configuration and an expanded configuration. A plurality of elongate electrode assemblies may be disposed on the balloon. A cover layer may be deposited on the electrode assemblies. Portions of the electrode assemblies may be free of the cover layer.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 23, 2021
    Inventors: Patrick A. Haverkost, Mary M. Byron, Cass A. Hanson, Martin R. Willard, Derek C. Sutermeister, Robert N. Squire, Brian K. Jablonski
  • Patent number: 10940301
    Abstract: The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: March 9, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Devin V. McAllister, Mark R. Prausnitz, Sebastien Henry
  • Patent number: 10914803
    Abstract: Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: February 9, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Jin Hyung Lee
  • Patent number: 10912939
    Abstract: An electroporation device for injecting a product into a ciliary muscle of an eye, said device comprising: a support having a support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, so as to match the outside surface of the eye, a first electrode comprising an invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, optionally an injection needle, wherein the support comprises an insertion guide configured to guide a sliding of said electrode needle and/or injection needle along a respective insertion axis, so that the angle between said insertion axis and a plane tangential to the virtual sphere at the insertion point is less than 40°, the insertion point being the point where said insertion axis crosses said virtual sphere.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: February 9, 2021
    Assignee: EYEVENSYS
    Inventors: Luc Lebreton, Elodie Touchard, Romain Benard, Karine Bigot, Cécile Madaras, Francine Behar-Cohen
  • Patent number: 10857028
    Abstract: A method of treating and managing diseased ocular tissue in the bulbar conjunctiva comprises providing a device comprising a plurality of microneedles arranged on a substrate contacting the device with a diseased ocular tissue region formed in the bulbar conjunctiva stroma to form a plurality of micro-injury sites therein. A device comprises a contact lens substrate comprising a substantially elliptical corneal portion and a limbus portion located radially about the corneal portion. A scleral portion is located radially about the substrate. The device is at least partially degradable and/or comprises a therapeutic compound. At least a portion of the scleral portion is configured to overlay, and deliver the therapeutic compound to a diseased ocular tissue located adjacent to the cornea of a patient.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 8, 2020
    Inventors: Sara Heikali, Moossa Heikali
  • Patent number: 10842676
    Abstract: An apparatus includes a rigid body, a flexible sealing element, a nozzle assembly, and an electrode. The rigid body defines a channel, a reservoir, and a vent path. The reservoir is in fluid communication with the channel. The vent path is in fluid communication with the reservoir. The reservoir is configured to provide spacing between the channel and the vent path. The sealing element is positioned distal to the rigid body. The nozzle assembly includes a nozzle head and a post. The post extends distally through the channel of the rigid body. The nozzle head projects distally from a distal end of the post. The electrode is disposed within the channel of the rigid body. The reservoir extends laterally from a longitudinal axis defined by the electrode.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: November 24, 2020
    Assignee: TUSKER MEDICAL, INC.
    Inventors: Miranda M. Ray, Rohit Girotra, Anh Quoc Truong, Radhika Patel, Thomas D. Gross, Alfredo Cantu
  • Patent number: 10835163
    Abstract: Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device and have a volume that is larger than a recess of the fluid transporter that receives fluid from a surface.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: November 17, 2020
    Assignee: Seventh Sense Biosystems, Inc.
    Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Li Yang Chu
  • Patent number: 10835688
    Abstract: A port-a-cath needle adapted for determining the position of the needle prior to dispensing medical treatments is disclosed. Disclosed embodiments of the port-a-cath needle comprises a cannula, a hollow needle, and an inflatable balloon. The balloon is disposed at the distal end of the port-a-cath needle such that when the needle is inserted into a patient, the balloon may be inflated and the resistance pressure used to determine if the needle is inserted into the port chamber or a port-a-cath device or is surrounded by soft tissue. In certain embodiments, the balloon may be maintained in the inflated configuration in order to help retain the port-a-cath needle within the port chamber while treatment is delivered to the patient.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: November 17, 2020
    Inventor: Tejash Patel
  • Patent number: 10821021
    Abstract: An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: November 3, 2020
    Inventors: Michael F. Clem, Benjamin L. Ko, Robert H. Roth, Daniel J. Abbott, Thomas E. Meyer, Paul D. Gordon
  • Patent number: 10814115
    Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: October 27, 2020
    Inventors: Carlo Giovanni Traverso, Avraham D. Schroeder, Baris Erinc Polat, Carl Magnus Schoellhammer, Daniel Blankschtein, Daniel G. Anderson, Robert S. Langer
  • Patent number: 10799289
    Abstract: Disclosed are compositions, devices, systems, kits, and methods for neural ablation.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: October 13, 2020
    Assignee: Avent, Inc.
    Inventors: Guillermo Alas, Michael G. Smith, Sherry E. Adesina, Alencia V. Washington
  • Patent number: 10709463
    Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: July 14, 2020
    Assignee: COVIDIEN LP
    Inventors: Gaurav Girdhar, Dinh Nguyen, Hoai Nguyen
  • Patent number: 10682504
    Abstract: A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: June 16, 2020
    Inventor: Hiroyuki Kato
  • Patent number: 10667857
    Abstract: Tissue may be cut and extracted from an interior location in a patient's body using a probe or tool which both effects cutting and causes vaporization of a liquid or other fluid to propel the cut tissue through an extraction lumen of the cutting device. The cutting may be achieved using an electrosurgical electrode assembly, including a first electrode on a cutting member and a second electrode within a cutting probe or tool. Thus, over a first cutting portion, radio frequency current may help cut the tissue and over a second or over transition region, the RF current may initiate vaporization of the fluid or other liquid to propel the tissue from the cutting device.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 2, 2020
    Inventors: John H. Shadduck, Aaron Germain, Csaba Truckai, Kyle Klein, Michael D. Walker
  • Patent number: 10668261
    Abstract: The purpose of the present invention is to provide a sheet-like piece comprising; a base sheet comprising an elastic material; a reservoir layer provided on the surface of said base sheet which contains a physiologically active substance and comprises micro needles; a adhesion layer which is formed in a mesh form on said base sheet and; a adhesion assisting layer which is formed on the surface of opposite side of said base sheet to the surface formed said reservoir layer. As a result, the sheet for promoting hair growth which may restore the state of thin hair to a state before thinning, a whitening and wrinkle ameliorating agent having whitening effect and wrinkle improving effect, and sheet-like piece used for these are provided.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: June 2, 2020
    Assignee: QUARRYMEN&CO. INC.
    Inventors: Hiroshi Hochi, Yasuhiro Yamashita
  • Patent number: 10653880
    Abstract: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: May 19, 2020
    Assignees: Eastern Virginia Medical School, Old Dominion University Research Foundation
    Inventors: Stephen J. Beebe, Karl H. Schoenbach
  • Patent number: 10588687
    Abstract: A system and method for applying energy, particularly radiofrequency (RF) electrical energy, to a living body can be used in tissue ablation and includes a combination of cannulas, guidance stylets, and a cooled high-frequency electrode.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: March 17, 2020
    Inventors: Eric R. Cosman, Jr., Eric R. Cosman, Sr.
  • Patent number: 10589272
    Abstract: Devices, systems, and methods for separating cells or vesicles using a thermo-acoustophoretic approach are provided. A microfluidic device can be used for stiffness-based separation of cells or vesicles that otherwise have the same or approximately the same size, shape, and charge, where at least some of the membranes or vesicles have different compositions. The separation can be done by tuning the temperature of the cells or vesicles.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 17, 2020
    Assignee: The Florida International University Board of Trustees
    Inventors: Bilal El-Zahab, Ata Dolatmoradi
  • Patent number: 10568686
    Abstract: A catheter has a balloon electrode assembly with at least one compliant balloon member and at least one electrode carried on an outer surface of the balloon member for accomplishing circumferential sensing or ablation in a tubular region of the heart, including a pulmonary vein or ostium. The catheter may also include an electrode assembly with a tip and/or ring electrode distal of the balloon electrode assembly adapted for focal contact.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: February 25, 2020
    Inventor: Christopher Lee
  • Patent number: 10569086
    Abstract: A method is provided that includes positioning electrodes in or in contact with the head of a subject identified as in need of enhanced microglial cell activation. Control circuitry is activated to drive the electrodes to apply an electrical current to the brain of the subject, and to configure the electrical current to enhance microglial cell activation for taking up a substance from brain parenchyma. Other embodiments are also described.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: February 25, 2020
    Inventors: Gideon Fostick, Yossi Gross, Alex Tendler
  • Patent number: 10548816
    Abstract: A naso/orogastric device having backflow blocking means and comprises a naso/orogastric tube sized and shaped for being disposed within the esophagus so that at least a distal end thereof being placed in the stomach lumen of a patient, at least one elastic esophageal body, positioned along the naso/orogastric tube, having a pressure dependent volume, at least one esophageal sensor that detects fluid around at least one segment of the naso/orogastric tube, and a pressure regulator that regulates a pressure within the elastic esophageal body according to the detection.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: February 4, 2020
    Assignee: ART Healthcare Ltd.
    Inventors: Liron Elia, Nir Lilach, Eliahu Eliachar
  • Patent number: 10548653
    Abstract: An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: February 4, 2020
    Assignee: Tsunami MedTech, LLC
    Inventors: Michael Hoey, John H. Shadduck
  • Patent number: 10524847
    Abstract: A surgical instrument for thermally-mediated therapies in targeted tissue volumes and for causing thermal effects in polymer tissue-contacting members. In one embodiment, the instrument has a working end with an interior chamber that is supplied with a biocompatible liquid. An energy source causes a liquid-to-vapor phase change within the interior of the instrument. The vapor phase media then is ejected from the working surface of the instrument, and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat of vaporization to ablate tissue. The vapor-to-liquid phase transitions, or internal energy releases, can be provided about thin-film flexible structures for engaging body lumens and cavities. An exemplary embodiment can be used for shrinking, sealing, welding or creating lesions in tissue—while causing limited collateral thermal damage and while totally eliminating electrical current flow in the engaged tissue.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 7, 2020
    Assignee: Tsunami MedTech, LLC
    Inventor: John H. Shadduck
  • Patent number: 10524864
    Abstract: A catheter is disclosed for locating radiation tagged tissue within a mammalian body and treating tagged tissue or untagged tissue adjacent to the tagged tissue in a single procedure. The catheter includes in or on a distal end thereof one or more detectors for locating labeled tissue. A lumen extending from a proximal end of said tube to the distal end of said tube, includes a retractable and extendable needle positioned adjacent the distal end of said tube for delivering a liquid treatment modality. I the alternative the injector for delivering the treatment modality may be placed adjacent to the catheter for delivery of the treatment.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: January 7, 2020
    Inventors: Albert J. Sinusas, Farhad Daghighian
  • Patent number: 10478640
    Abstract: Placement of a vascular access device (intravenous, intra-arterial and/or intra-osseous vascular access) in a non-sterile environment greatly increases the risk of infection via the vascular access device. This invention provides an approach for accomplishing sterilization of the site where vascular access will be attempted under non-sterile field conditions. In addition, this invention provides a sterile vascular connector pre-loaded with an antimicrobial, e.g., Taurolidine. Use of the vascular connector provides the antimicrobial concurrently with achieving vascular access, which limits the risk of infection despite access placement under non-sterile field conditions.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 19, 2019
    Assignee: CorMedix Inc.
    Inventors: Bruce Reidenberg, Antony Pfaffle, Robert DiLuccio
  • Patent number: 10448815
    Abstract: A method and system are described for generating a signal indicative of an intravascular image received at least partly via a light transducer and invoking circuitry for passing the generated signal out of a subject's body.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: October 22, 2019
    Assignee: GEARBOX, LLC
    Inventors: Edward K. Y. Jung, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Clarence T. Tegreene, Lowell L. Wood, Jr.