Means For Introducing Or Removing Material From Body For Therapeutic Purposes (e.g., Medicating, Irrigating, Aspirating, Etc.) Patents (Class 604/19)
  • Patent number: 10632013
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 28, 2020
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Patent number: 10617716
    Abstract: The present invention in various aspects and embodiments provides methods and formulations for treating inflammatory conditions of the skin and/or conditions involving compromised skin barrier function. Such diseases include blistering diseases of the skin, hereditary defects in skin barrier function, hyperproliferative conditions involving the skin, conditions associated with aging or damaged skin, immunological disorders involving the skin, among others.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 14, 2020
    Assignee: URGO US, INC.
    Inventors: Mark Sampson, Svetlana Panicheva, Cary Schockemoehl
  • Patent number: 10528782
    Abstract: One method for estimating the extracorporeal blood volume in a portion of a physical sample includes: extracting a feature from a portion of an image of the sample; tagging the portion of the image of the sample with a blood volume indicator according to the extracted feature; and estimating the extracorporeal blood volume in at least the portion of the physical sample, associated with the portion of the image of the sample, according to the blood volume indicator.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 7, 2020
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Kevin Miller, Ali Zandifar
  • Patent number: 10485957
    Abstract: Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: November 26, 2019
    Assignee: Muffin Incorporated
    Inventors: Neal E. Fearnot, Peter S. McKinnis, Kem Hawkins
  • Patent number: 10485919
    Abstract: A kit to facilitate creation of and compliance with a personalized injection site rotation plan includes a plurality of disposable injection devices adapted for giving an injection of a medication to a patient in need thereof, each disposable injection device having a permanent, distinctive mark that may be the same as or different from the distinctive mark on other disposable injection devices in the kit; and a plurality of user-defined association tools, wherein for each unique distinctive mark on a disposable injection device, at least one user-defined association tool has a distinctive mark that corresponds to the unique distinctive mark.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 26, 2019
    Assignee: Montmed Inc.
    Inventors: Amir Farzam, Allison Olenginski
  • Patent number: 10478532
    Abstract: A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 19, 2019
    Assignee: Alcon Research, Ltd.
    Inventors: Glenn Robert Sussman, Mikhail Boukhny, John Morgan Bourne
  • Patent number: 10473062
    Abstract: A fuel vapor processing device includes a three-way valve having a common valve chamber in which a first valve body, a second valve body, and a third valve body are housed. A single pressure sensor is provided in the common valve chamber. The first valve body enables communication between the common valve chamber and a first valve chamber. The second valve body enables communication between the common valve chamber and a second valve chamber communicating with an inside of the canister. The third valve body enables communication between the common valve chamber and a third valve chamber communicating with an inside of a fuel tank. An ECU controls the three-way valve and a switching valve, and controls driving of a pump to perform fuel vapor leak diagnosis for the fuel tank and the canister, based on a detection value detected by the pressure sensor.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 12, 2019
    Inventors: Keiichirou Ishihara, Tomohiro Itoh
  • Patent number: 10441778
    Abstract: An implantable medical device for providing phototherapy to a patient's brain is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient. A light path is attached to the housing. The implantable medical device is configured to be positioned between a patient's skull and scalp with the light path extending into the patient's brain, such that light from the light source can irradiate a target position within the patient's brain. The implantable medical device is powered and controlled by an implantable pulse generator (IPG) that may be implanted into a patient's tissue remotely from the device and connected to the device by wire leads.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 15, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: William G. Orinski
  • Patent number: 10371775
    Abstract: This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a method includes using a medical fluid pump of a medical fluid pumping machine, such as a hemodialysis machine, to deliver medical fluid to a first portion of a cartridge that is positioned within a magnetic field, exciting atoms in the medical fluid in the first portion of the cartridge by applying radio frequency energy to the medical fluid in the first portion of the cartridge, receiving radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge, and determining a concentration of a substance in the medical fluid based on the received radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: August 6, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Ross Peter Jones, Martin Joseph Crnkovich, Fei Wang, Thomas Irvin Folden, Lynn Jensen, Shashikant Dattatraya Kalaskar
  • Patent number: 10315020
    Abstract: A device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame. The active substance dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device includes a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: June 11, 2019
    Inventors: Uwe Wortmann, Roman Hadaschik, Michael Horstmann
  • Patent number: 10300195
    Abstract: A method of operating an infusion device that includes the steps of actuating a fluid transfer device, which is configured to deliver a predetermined volume during each actuation, in accordance with a delivery profile that includes a plurality of fluid transfer device actuations, determining, based on sensed pressure, whether an actual volume delivered during a fluid transfer device actuation is the predetermined volume, and adjusting the number of actuations in the delivery profile in response to the actual volume delivered differing from the predetermined volume.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 28, 2019
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Christian M. Merot, Pedrum Minaie
  • Patent number: 10265341
    Abstract: The present invention relates to a hydrogel formulation containing an oxidative reduction potential (ORP) water solution and a gelling agent. The invention further provides a method for treating or preventing a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a hydrogel formulation comprising an oxidative reductive potential solution and a gelling agent. A method for promoting wound healing in a patient is also provided.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 23, 2019
    Assignee: Sonoma Pharmaceuticals, Inc.
    Inventor: Robert Northey
  • Patent number: 10252077
    Abstract: A method of irradiating spinal tissue with red/NIR light, comprising: inserting a cannulated device defining a bore into the spinal column, wherein the bore contains an optically transparent substrate adapted to emit red/NIR light, and transmitting NIR/red light through the substrate to irradiate tissue within the spinal column.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: April 9, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mohamed Attawia, Thomas M DiMauro, Jeffrey K Sutton
  • Patent number: 10245441
    Abstract: An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: April 2, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Brad C. Tischendorf, Gordon O. Munns, Christian S. Nielsen, John D. Norton, Markus W. Reiterer, Andrew J. Thom, Kunal J. Paralikar
  • Patent number: 10245443
    Abstract: Disclosed herein is a method of treating a patient that involves injecting a flowable material into a cancellous bone region of a bone, wherein the material is adapted to facilitate tissue regeneration, and then irradiating the cancellous bone region with an effective amount of NIR/red light. The irradiation may be carried out from a light source located inside the bone. The light may enter the bone via a transmitter located underneath the skin of the patient.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: April 2, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mohamed Attawia, Thomas M DiMauro, Jeffrey K Sutton
  • Patent number: 10238890
    Abstract: Methods and apparatus for the inactivation of infectious agents in, on or around a catheter residing in a patient's body cavity. The method comprises a coupling adapter for facilitating the transmission of non-ultraviolet sterilizing electromagnetic radiation (EMR) substantially axially along an optical element into the catheter body. Through delivery of the sterilizing EMR to particular areas of highest infection, the present disclosure is able to inactivate the major sources of infection in catheters.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: March 26, 2019
    Assignee: Light Line Medical, Inc.
    Inventors: Nathaniel L. Rhodes, Adam E. Bracken, Martin de la Presa, Ahrash E. Poursaid, Ryan R. Coil, Mitchell D. Barneck, James P. Allen
  • Patent number: 10201647
    Abstract: Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: February 12, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael G. Norris, Jacob W. Scarpaci, Robert J. Bryant, Jr., Geoffrey P. Spencer, David J. Hibbard, James D. Dale, John M. Kerwin, Andrew S. Coll, David A. Beavers, David W. McGill, Simon C. Helmore, David B. Doherty, Edgar J. Bolton, Jinsun Yoo, Paul G. Girouard, Daniel S. Karol, Daniel B. Singer, Joseph P. Rushlow
  • Patent number: 10159825
    Abstract: A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 25, 2018
    Assignee: ZipLine Medical, Inc.
    Inventors: Amir Belson, Brian Beckey, James J. Leary
  • Patent number: 10105518
    Abstract: A neuro-surgery assembly includes a neuro-catheter slidably received over a wire guide. The wire guide includes an inner tube positioned within an elongate hollow tube that includes a pattern of openings at its distal segment to provide an atraumatic tip for reaching sensitive locations in a brain. The wire guide is changeable between a stiff condition in which the inner tube is pressurized and a soft condition in which the inner tube is depressurized. The user may switch between the stiff and soft conditions to negotiate the tortuous pathway to a brain treatment site without a need to swap out to a different wire guide to support advancement of the neuro-catheter.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: October 23, 2018
    Assignee: Cook Medical Technologies LLC
    Inventor: Palle Munk Hansen
  • Patent number: 10016618
    Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 10, 2018
    Inventors: Alan D. Hirschman, Arthur E. Uber, III, David M. Reilly, John F. Kalafut, Frederick W. Trombley, III, Steven J. Remis, Scott Griffith, Douglas Descalzi, Richard Dewit, David M. Griffiths, Marc A. Mabie, Mark Trocki
  • Patent number: 9775798
    Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 3, 2017
    Inventors: Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
  • Patent number: 9679879
    Abstract: Provided is a LED light-emitting device including: a carrier, which is a transparent body, and on a carrying surface of which conductors are provided; a plurality of LED chips, which are electrically connected to the conductors by way of eutectic bonding, so as to realize electrical connection among the plurality of LED chips; an encapsulation structural member, which is a transparent body and encapsulates on the periphery of the carrier and the LED chips; and a pair of electrodes, wherein positive electrode/negative electrodes in the pair of electrodes are electrically connected to the LED chips located at the most upstream/most downstream of a current transmission in the plurality of LED chips by means of the conductors, and extend to the outside of the encapsulation structural member.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: June 13, 2017
    Assignees: Zhejiang Zhongzhou Lighting Technology Co., Ltd.
    Inventor: Xiaobiao Zhu
  • Patent number: 9649131
    Abstract: The present application relates to a microdermabrasion device (1). The device has a suction path (11) along which skin fragments removed by the device are drawn, and a detection unit (3) configured to determine one or more characteristics of skin fragments drawn along the suction path. The detection unit is configured to determine the depth of abrasion performed by the device based on the one or more characteristics of skin fragments drawn along the suction path. The present application also relates to a method of determining the operating depth of abrasion of a microdermabrasion device.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: May 16, 2017
    Inventors: Linda Goverdina Maria Beijens, Martin Jurna, Antonius Maarten Nuijs, Maria Angelina Josepha Grootel-Rensen, Caecilia Hendrina Theodora Chlon
  • Patent number: 9549851
    Abstract: A surgical hand piece comprises a shell, a channel having an irrigation conduit, and a sensor housing. The channel is coupled to the shell such that the proximal end of the channel is located at the proximal end of the shell and the distal end of the channel is located near the distal end of the shell. The sensor housing has an irrigation path extending through it. The sensor housing has a seal interface on one end. The seal interface end of the sensor housing is coupled to the proximal end of the channel such that the irrigation conduit of the channel is fluidly coupled to the irrigation path of the sensor housing.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 24, 2017
    Assignee: Novartis AG
    Inventors: James Yong Chon, Robert Stephen Maurer, Jr., Satish Yalamanchili
  • Patent number: 9461421
    Abstract: A catheter assembly includes a catheter handle having a handle body defining a bore and having a proximal part and a distal end. A catheter sheath has a proximal part received in the bore of the handle body, the catheter sheath projecting from the distal end of the catheter handle and the proximal part of the catheter sheath carrying a series of spaced electrically conductive members. Each conductive member is electrically connected to a conductor extending in the catheter sheath from the proximal part towards a distal end of the catheter sheath. A carrier is arranged in the bore of the catheter handle, the carrier carrying a series of spaced electrical contacts with each contact being configured to make electrical contact with one of the electrically conductive members of the catheter sheath.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: October 4, 2016
    Assignee: CathRX LTD
    Inventor: David Ogle
  • Patent number: 9089650
    Abstract: An assembly including a drug delivery device and a monitoring device adapted to detect an action taking place in the drug delivery device. The drug delivery device including a main portion having a drug expelling mechanism for expelling drug from the reservoir through an outlet, a housing in which at least a portion of the expelling mechanism is arranged, and a member able to attach a cover to the drug delivery device. The cover is adapted to cover the outlet when mounted. The monitoring device includes a housing portion, a member for detecting an action taking place in the drug delivery device, and at least one member adapted to engage a member present on the main portion. By this arrangement the monitoring device can be placed in a pre-determined position relative to the main portion, allowing efficient transmission of information between the monitoring device and the main portion.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: July 28, 2015
    Assignee: Novo Nordisk A/S
    Inventors: Ole Christian Nielsen, John Østergaard Madsen
  • Patent number: 9033910
    Abstract: The invention relates to a bracelet that is suitable for the transdermal delivery of various substances. The invention relates to, for example, a refillable, hollow bracelet that contains the substance and that is also provided with a filter that enables the product to be absorbed when in contact with the skin of the user. A mechanism enables the supply of said substance to be totally or partially interrupted. Additionally, the bracelet has a refilling device for refilling the bracelet when the substance runs out.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: May 19, 2015
    Inventor: Marta Perez De La Iglesia
  • Patent number: 9011394
    Abstract: The present invention relates to a sheet structure for application to a region of the human body, including the face, the structure comprising: a colored matrix; a first substrate situated on a first side of the matrix, a first surface of the sheet structure being defined by the first substrate; and a second substrate situated on a second side of the matrix, opposite the first, a second surface of the sheet structure being defined by the second substrate; the first and second substrates having different opacities, and at least one of the first and second substrates having an opacity that is low enough to enable the subjacent colored matrix to show through in such a manner that the first and second surfaces of the matrix appear to be of different colors.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: April 21, 2015
    Assignee: L'Oreal
    Inventors: Jean-Louis Gueret, Montserrat Tugas Casanoves
  • Publication number: 20150101595
    Abstract: A piercing device for use in internally pierced blister delivery devices include a base, a piercer body and an internal fluid path. The internal fluid path includes one or more inlet channels into a central cavity which is connected to one or more delivery channels and exit ports. The cavity is defined by angular walls and top to create turbulence in the fluid flow and to produce a controllable spray, mist, drops, plume or stream delivery. The piercer body also provides a pointed lancet disposed in the center of the exit ports for piercing the lidstock of a formed blister.
    Type: Application
    Filed: October 15, 2014
    Publication date: April 16, 2015
    Inventors: Jesse Ryan Hancock, Michael Shaw
  • Patent number: 9008759
    Abstract: A system enables determination of at least one parameter for an injection procedure to be performed on a patient in connection with a diagnostic imaging procedure. The system includes a processor and one or more algorithms. Embodied within the algorithm(s) is a model descriptive of the propagation of a fluid within the patient from a site of injection thereof to each of at least two regions of interest thereof. The algorithm(s) permits one discrete data point from each of at least two time enhancement curves, derived via a test bolus, to be input into the model to determine values of physiological parameters associated with the patient, preferably those related to cardiopulmonary function. The algorithm(s) also allows the values of the physiological parameters to be input into the model wherein the parameter(s) of the injection procedure that will be performed on the patient at issue are determined.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: April 14, 2015
    Assignee: Bayer Medical Care Inc.
    Inventors: John F. Kalafut, Corey Kemper
  • Patent number: 8998848
    Abstract: Apparatus and methods are provided to access bone marrow at various target areas. Such apparatus may include an intraosseous device operable to penetrate bone at a selected target area and a depth limiter operable to control depth of penetration of the intraosseous device into bone and associated bone marrow. A manual driver and a guide may be included to optimize optimum insertion of the intraosseous device at a selected insertion site on a sternum.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: April 7, 2015
    Assignee: Vidacare LLC
    Inventors: Larry J. Miller, Robert W. Titkemeyer, David S. Bolleter, Ruben Trevino, Matthew T. Harmon, Christopher Kilcoin
  • Patent number: 8992458
    Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 31, 2015
    Assignee: Alcyone Lifesciences, Inc.
    Inventors: Deep Arjun Singh, PJ Anand
  • Patent number: 8992460
    Abstract: To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to either the fluid barrier formed over the biofilm or a body surface proximal to the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: March 31, 2015
    Inventor: Michael Rontal
  • Patent number: 8992442
    Abstract: The invention relates to a device for taking a liquid bone marrow sample (aspiration) and a solid bone sample (biopsy) in the same procedure, which can thus replace specialized needles for taking bone marrow and needles exclusively used for taking bone biopsies. The device for taking liquid bone marrow samples and a solid bone sample has a simple mechanism that uses two grooved clamps, it is easy to disassemble for sterilization and its handle is designed to perform the puncture easily. The needle of the device is hollow, and within it a guide is placed with two sections of different diameters. The guide makes it possible to open up the empty needle channel to allow the bone marrow liquid to flow and be extracted, and also to close the channel to be able to penetrate the tissue. The purpose of this invention is to combine the procedures of bone marrow aspiration and bone biopsy, thus reducing the patient's discomfort and the time needed for the procedure.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: March 31, 2015
    Assignee: Instituto Tecnologico y de Estudios Superiores de Monterrey
    Inventors: Jorge Armando Cortes Ramirez, Sergio Gallegos Cazares, Jose Rafael Borbolla Escoboza, Lucio Florez Calderon, Manuel Ignacio Varela Jimenez
  • Patent number: 8992427
    Abstract: A system for deploying needles in tissue includes a controller and a visual display. A treatment probe has both a needle and tines deployable from the needle which may be advanced into the tissue. The treatment probe also has adjustable stops which control the deployed positions of both the needle and the tines. The adjustable stops are coupled to the controller so that the virtual treatment and safety boundaries resulting from the treatment can be presented on the visual display prior to actual deployment of the system.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: March 31, 2015
    Assignee: Gynesonics, Inc.
    Inventors: Michael A. Munrow, Darrin Uecker, Brian Placek, Harry Kwan, David Toub, Cameron D. Hinman, David J. Danitz
  • Patent number: 8986328
    Abstract: In a background-art medical gripping device, when a wall surface of an in vivo tissue has a large tear, a side portion of the tear can be gripped by the gripping device, but the other side portion opposed to the side portion cannot be gripped simultaneously. Therefore, to close the tear, complicated operation is required to be performed using plural gripping devices. A medical gripping device according to the present invention includes a fixed clip, a pair of movable clips made from an elastic material and provided to face the fixed clip, the movable clips having lower ends fixed to the fixed clip and the other ends opened, and a control mechanism which shifts from each other a timing at which a gripping target is gripped between one of the movable clips and the fixed clip and a timing at which the target is gripped between the other movable clip and the fixed clip.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: March 24, 2015
    Assignee: Piolax Medical Devices, Inc.
    Inventors: Yoshinori Mizumoto, Tsuyoshi Nakakubo
  • Patent number: 8979818
    Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: March 17, 2015
    Assignee: Cellectis
    Inventors: Derin C. Walters, Alan D. King, Anna-Karin Roos, Robert J. Walters
  • Patent number: 8979785
    Abstract: An applicator device for applying a fluid is provided. The applicator device may include a handle. The handle may comprise an elongate hollow body having a proximal end and a distal end and at least one longitudinal, interior rib disposed on an inner surface of an outer wall of the hollow body and configured to orient and guide a container for containing the fluid when the container is disposed within the hollow body. In addition, the applicator device may include a base at the distal end of the hollow body. Further, the applicator device may include an applicator pad coupled to the base.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: March 17, 2015
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Todd M. Korogi, Theodore J. Mosler, Matthew R. Penny, Bryan J. Peters, Lisa D. Shaffer, Andrew Corson, Ronald J. Casey, Patrick P. Vanek, Royal D. Hathaway
  • Publication number: 20150065946
    Abstract: The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors here disclose that a solution comprising calcium ions (Ca2+) with a concentration of at least 0.1 M is extremely useful in a method of treating a neoplasm, such as cancer with means for causing transient permeabilisation of the cell membranes of at least part of the neoplasm before, during and/or after administration of said solution, wherein said solution is administered with a ratio of 0.2 to 0.8 of the volume of said part of the neoplasm.
    Type: Application
    Filed: December 21, 2012
    Publication date: March 5, 2015
    Inventors: Karen Julie Gehl, Stine Krog Frandsen, Jens Ole Eriksen, Hanne Margrethe Gissel Hyldkrog, Pernille Højman Jensen
  • Patent number: 8961448
    Abstract: An implantable drainage device is provided. The device is adapted to move body fluid from one part of the body of a patient to another part of the body.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: February 24, 2015
    Inventor: Peter Forsell
  • Patent number: 8951221
    Abstract: The invention relates to a method and device for the treatment of glaucoma, though insertion of an implant into the lumen of the Schlemm's canal to realize proper drainage of the aqueous humor, which implant is brought into its position in the Schlemm's canal by means of a catheter having a distal and a proximate portion and provided with a number of pores through which a gaseous or fluid medium which comes from a pressure source can emerge during insertion of the catheter carrying the implant into the Schlemm's canal, and while the catheter is being inserted into the Schlemm's canal the gaseous or fluid medium is released under pressure thereby expanding the Schlemm's canal and the implant and upon releasing the implant at its determined location, the catheter can be withdrawn from the Schlemm's canal.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: February 10, 2015
    Assignee: Grieshaber Ophthalmic Research Foundation
    Inventors: Robert Christopher Stegmann, Matthias Christian Grieshaber, Hans Rudolf Grieshaber
  • Patent number: 8945038
    Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 3, 2015
    Assignee: Transcend Medical, Inc.
    Inventor: Michael Yablonski
  • Patent number: 8945376
    Abstract: Systems, apparatus, methods, and articles of manufacture provide for resuspending and/or collecting blood and/or other types of cells in solution. In one embodiment, cells may be recovered from used surgical sponges and/or other types of surgical articles.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: February 3, 2015
    Assignee: All Cell Recovery LLC
    Inventor: Michael C. Cordisco
  • Patent number: 8945600
    Abstract: Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: February 3, 2015
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventor: Benjamin S. Bleier
  • Patent number: 8926548
    Abstract: The present invention provides: a superficial cerebral vascular bleeding inhibitor comprising an aqueous solution containing 120 to 160 mEq/L of sodium ion, 1 to 5 mEq/L of calcium ion, and 75 to 165 mEq/L of chloride ion; the superficial cerebral vascular bleeding inhibitor further comprising 1 to 5 mEq/L of potassium ion; and a packaged container containing the superficial cerebral vascular bleeding inhibitor (with or without potassium ion). The superficial cerebral vascular bleeding inhibitor of the present invention can effectively prevent or inhibit bleeding from superficial cerebral blood vessels in the field of neurosurgery such as intracranial surgery and the like, thereby capable of securing a clear operating field during intracranial surgery and inhibiting the occurrence of post-surgery damage.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: January 6, 2015
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Yasutaka Fujita, Kazuhisa Doi, Shuji Kamikawa
  • Patent number: 8924023
    Abstract: A method for evaluating dosing from an implanted infusion system that includes receiving input regarding the identity of a therapeutic agent into an external device. The method further includes displaying on the external device a predetermined set of symptoms associated with the therapeutic agent; receiving input into the external device regarding with which of the symptoms the patient presents; and determining whether the therapeutic agent is being delivered, or has been delivered, at an appropriate dose based on the input identity of the therapeutic agent and the input symptoms.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 30, 2014
    Assignee: Medtronic, Inc.
    Inventor: Emem Akpan
  • Patent number: 8915892
    Abstract: Extracorporeal blood treatment methods are usually performed with anticoagulation of the blood. In regional anticoagulation with citrate, sometimes a blood clot is observed in the extracorporeal circulation at the point of addition of the calcium substitution solution. In such a case, the treatment must be interrupted. To prevent such an interruption, the point of addition is configured as a T-piece having a spiral structure for generating turbulence.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: December 23, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Juergen Klewinghaus
  • Patent number: 8911426
    Abstract: An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: December 16, 2014
    Assignee: On Demand Therapeutics, Inc.
    Inventors: Jonathan Robert Coppeta, Kenneth N. Horne, John T. Santini, Jr., John A. Scholl, Gregory J. R. Spooner, Cynthia L. Stevenson, Naveed Shams, Andrew Poutiatine
  • Patent number: 8882707
    Abstract: A fluids exchanging system for medical use is provided. The system comprises an infusion pumping system, an aspiration pump, and an implantable catheter comprising a perforated dialysis cavity communicating with infusion and aspiration tubes in a communicating vessel manner. The implantable catheter further includes elastic holes.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 11, 2014
    Assignee: MICREL Medical Devices S.A.
    Inventor: Achilleas Tsoukalis
  • Patent number: 8877062
    Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: November 4, 2014
    Assignee: Interface Biologics, Inc.
    Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark Steedman, Roseita Esfand