Means For Introducing Or Removing Material From Body For Therapeutic Purposes (e.g., Medicating, Irrigating, Aspirating, Etc.) Patents (Class 604/19)
  • Patent number: 11291800
    Abstract: A catheter is provided that includes a catheter body, a catheter hub, and a securing member disposed in the catheter hub to clamp the catheter between the securing member and the catheter hub. The securing member has an outer peripheral surface making contact with and stretching an inner peripheral surface of the catheter body. The catheter includes a recessed relief portion into which a thickness of the catheter body is inserted, the relief portion being partially provided circumferentially in an inner peripheral surface of the catheter hub.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: April 5, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Takayuki Yokota
  • Patent number: 11285293
    Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: March 29, 2022
    Assignees: University Of Maryland, Baltimore, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, Jr., Mark E. Shirtliff
  • Patent number: 11266815
    Abstract: A closed-system, drug administering catheter assembly includes a transfer adapter, a stopcock, a medicament injector containing chemotherapy medicament, a medicament pressure reservoir, and a urethral balloon catheter comprising a drain lumen and a distal tip, all connected together in a closed-system. The medicament injector is configured to inject the chemotherapy medicament through the stopcock, the drain lumen, and into an environment of the distal tip within a patient's organ without leakage of the chemotherapy medicament from the patient into an environment of the patient. The medicament pressure reservoir is configured to store negative pressure that withdraws from the organ used chemotherapy medicament through the drain lumen and the stopcock and holds the used chemotherapy medicament in the medicament pressure reservoir without leakage of the used chemotherapy medicament into the environment of the patient.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 8, 2022
    Assignee: GENIUS MEDICAL SYSTEMS, LLC
    Inventors: Milena Bonanno, Charles Bonanno
  • Patent number: 11225409
    Abstract: A device includes a microelectromechanical system (MEMS) sensor die comprising a deformable membrane, a MEMS heating element, and a substrate. The MEMS heating element is integrated within a same layer and a same plane as the deformable membrane. The MEMS heating element surrounds the deformable membrane and is separated from the deformable membrane through a trench. The MEMS heating element is configured to generate heat to heat up the deformable membrane. The substrate is coupled to the deformable membrane.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: January 18, 2022
    Assignee: InvenSense, Inc.
    Inventors: Pei-Wen Yen, Ting-Yuan Liu, Jye Ren, Chung-Hsien Lin, Joseph Seeger, Calin Miclaus
  • Patent number: 11172851
    Abstract: A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: November 16, 2021
    Assignee: One Drop Biosensor Technologies, LLC
    Inventors: Ashwin Pushpala, Dominic Pitera, Matthew Chapman, Michael Gifford
  • Patent number: 11173129
    Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: November 16, 2021
    Assignee: The Regents of the University of California
    Inventors: Tejal Ashwin Desai, Hariharasudhan Chirra Dinakar, Cade B. Fox
  • Patent number: 11167148
    Abstract: A bone implant includes a bore extending entirely through the bone implant. The bone implant also includes a light source to emit light onto bone adjacent the bone implant to stimulate bone growth and/or reduce bone loss.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: November 9, 2021
    Assignee: CIMPHONI LIFE SCIENCES LLC
    Inventors: James T. Ninomiya, Janine A. Struve, Dorothee Weihrauch, Scott Howard Micoley, Dale Selsor DiIulio, Douglas J. Birkholz, Kyle Steven Jansson, Richard B. Davidson
  • Patent number: 11166656
    Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: November 9, 2021
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Phillip Yee, Christopher A. Thomas, Udo Hoss, Lei He, Michael R. Love
  • Patent number: 11110290
    Abstract: An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: September 7, 2021
    Assignee: Medtronic, Inc.
    Inventors: Brad C. Tischendorf, Gordon O. Munns, Christian S. Nielsen, John D. Norton, Markus W. Reiterer, Andrew J. Thom, Kunal J. Paralikar
  • Patent number: 11077254
    Abstract: A smart plunger rod adapted to push a medication out of a syringe is disclosed. The plunger rod comprises a shaft sized and dimensioned to act on a piston on the syringe and a finger actuated head portion containing at least two subunits of a wireless sensor. In a pre-activation configuration, the subunits are spaced apart from each other by a physical barrier and the wireless sensor is non-operational. In a post-activation configuration, the subunits are connected to each other and the sensor is operational to send a signal. A user activates the finger actuated head portion to reversibly move the physical barrier and moves the plunger rod from the pre-activation configuration to the post-activation configuration. The signal sent by the sensor comprises information relating to ejecting the medication out of the syringe, and is received by a remote receiver.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: August 3, 2021
    Assignee: MEDIMMUNE, LLC
    Inventors: Janardhanan Anand Subramony, Michael C. Song
  • Patent number: 11039981
    Abstract: A portable eye washing station includes a spike that can pierce a fluid source and the spike is hollow to pass fluid therethrough. A feed tube is fluidly coupled to the spike to receive the fluid from the spike. A fitting is fluidly coupled to the second end of the feed tube and the fitting has a pair of outputs to pass the fluid therethrough. A distribution tube is fluidly coupled to each of the outputs on the fitting such that the distribution tube forms a closed loop for wearing around a user's head. A cannula is fluidly coupled to the distribution tube to release the fluid and the cannula has a pair of outlets. Each of the outlets is aligned with a respective one of the user's eyes when the distribution tube is worn around the user's head. Thus, each of the outlets directs the fluid into the user's eyes for flushing the user's eyes.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: June 22, 2021
    Inventors: James Dwyer, Terry Callanan
  • Patent number: 11033428
    Abstract: A phacoemulsification tip, including an aspiration tube presenting a cutting tip at a distal end. The aspiration tube has a tube wall presenting an internal face and an external face. The internal face supports at least one internally extending internal ridge. The at least one internal ridge presents an internal distal face, an internal proximal face and an internal apex. The internal distal face meets the internal face at an acute angle measured internally. The at least one internal ridge is structured to engage lens fragments separated from a crystalline lens to enhance proximal movement of the lens fragments and to inhibit distal movement of the lens fragments through the aspiration tube.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: June 15, 2021
    Inventor: William F. Wiley
  • Patent number: 11013440
    Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: May 25, 2021
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Daniel H. Lee, Michael R. Love, Louis G. Pace, Phillip Yee
  • Patent number: 11015986
    Abstract: A temperature sensor comprising a light emitter, an electrical circuit for applying a reverse bias voltage across the light emitter and for measuring a reverse current, and means for calculating a temperature from the measured reverse current.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 25, 2021
    Assignee: University of Newcastle Upon Tyne
    Inventors: Fahimeh Dehkhoda, Patrick Degenaar, Ahmed Soltan
  • Patent number: 10946212
    Abstract: The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: March 16, 2021
    Assignee: Commissariat à l'Energie Atomique et aux Energies Alternatives
    Inventors: Claude Chabrol, Alim-Louis Benabid
  • Patent number: 10926072
    Abstract: An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: February 23, 2021
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Tomoya Sumida, Yumiko Ikeda, Masaki Kono, Yoshihiro Kodama, Kazuhiko Shiomitsu
  • Patent number: 10881808
    Abstract: A button-activated medicament delivery device is presented having a housing arranged to house a medicament container, a vibration sensor configured to measure vibrations induced by the button-activated medicament delivery device during a medicament delivery, a button arranged to initiate medicament delivery from the medicament container, and to activate the vibration sensor when initiating the medicament delivery, and processing circuitry configured to obtain a vibration measurement from the vibration sensor and to compare the vibration measurement with a reference vibration measurement characteristic for the button-activated medicament delivery device during medicament delivery. The processing circuitry is configured to generate a time of measurement of the vibration measurement in case the vibration measurement matches the reference vibration measurement.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: January 5, 2021
    Assignee: SHL MEDICAL AG
    Inventor: Daniel Säll
  • Patent number: 10806510
    Abstract: Tissue is resected and extracted from an interior location in a patient's body using a probe or tool which both effects resection and causes vaporization of a liquid or other fluid to propel the resected tissue through an extraction lumen of the resecting device. Resection is achieved using an electrosurgical electrode assembly including a first electrode on a resecting member and a second electrode within a resection probe or tool. Over a first resecting portion, radio frequency current helps resect the tissue and over a second or over transition region, the RF current initiates vaporization of the fluid or other liquid to propel the tissue from the resection device. In one embodiment, an extending element extends from a housing and into a channel in a resecting member as the resecting member moves toward a distal position.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: October 20, 2020
    Assignee: MINERVA SURGICAL, INC.
    Inventors: Aaron Germain, Michael D. Walker, Benedek Orczy-Timko
  • Patent number: 10799229
    Abstract: A surgical retractor comprising a handle and a blade extending at an angle from the handle, an illumination assembly having a plurality of direct light sources provided on the blade, and a cover configured to enclose the illumination assembly, wherein the cover comprises a plurality of openings, each opening corresponding in position to a respective light source of the illumination assembly when the cover is attached to the blade.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: October 13, 2020
    Assignee: OBP Medical Corporation
    Inventors: Jeffrey Ralph Swift, Jason Swift, Matthew Traub, Nicholas Lauder
  • Patent number: 10793625
    Abstract: The present invention relates to the field of osteoarthritis. More specifically, the present invention provides compositions and methods useful for treating or preventing osteoarthritis. In one embodiment, a method for treating or preventing osteoarthritis in a patient comprises the step of administering to the patient a therapeutically effective amount of a transforming growth factor beta (TGF-beta) inhibitor.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: October 6, 2020
    Assignee: The Johns Hopkins University
    Inventor: Xu Cao
  • Patent number: 10744035
    Abstract: Systems and processes for facilitating the removal of cataract material with a robotically assisted tool with laser, irrigation capabilities, aspiration capabilities. Tool guidance systems that make use of vision technologies, including optical coherence tomography (OCT), white light imaging, and structured light imaging. Emulsification patterns optimized to minimize risk to the patient and reduce procedure time. Robotic tools with articulation capabilities that allow for precise control during capsulorhexis and emulsification procedures. Robotic instrument drive mechanisms combined with pumps, flow meters, and valves regulate and control irrigation and aspiration functionalities during robotic ophthalmologic procedures.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 18, 2020
    Assignee: Auris Health, Inc.
    Inventors: Jeffery B. Alvarez, Greg Kintz, David Mintz, Serena Wong
  • Patent number: 10736580
    Abstract: An optical circuit detects PPG signals reflected from skin tissue at one or more different wavelengths. A processing circuit integrated in the biosensor or in communication with the biosensor identifies an insulin release event using the a first PPG signal at a first wavelength and second PPG signal at a second wavelength. A correlation function is performed on the first and second PPG signals during the insulin release. The correlation is used to determine a relative change in diameter of vessels during the insulin release event and determine vascular health in response to the relative change.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: August 11, 2020
    Assignee: SANMINA CORPORATION
    Inventor: Robert Steven Newberry
  • Patent number: 10729916
    Abstract: Methods and apparatus for the inactivation of infectious agents in, on or around a catheter residing in a patient's body cavity. The method comprises a coupling adapter for facilitating the transmission of non-ultraviolet sterilizing electromagnetic radiation (EMR) substantially axially along an optical element into the catheter body. Through delivery of the sterilizing EMR to particular areas of highest infection, the present disclosure is able to inactivate the major sources of infection in catheters.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: August 4, 2020
    Assignee: Light Line Medical, Inc.
    Inventors: Mitchell D. Barneck, Nathaniel L. Rhodes, James P. Allen, Martin de la Presa
  • Patent number: 10716878
    Abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: July 21, 2020
    Assignee: The Regents of the University of California
    Inventors: B. Chia Soo, Kang Ting, Zhong Zheng
  • Patent number: 10632013
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 28, 2020
    Assignees: GEORGIA TECH RESEARCH CORPORATION, EMORY UNIVERSITY
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Patent number: 10617716
    Abstract: The present invention in various aspects and embodiments provides methods and formulations for treating inflammatory conditions of the skin and/or conditions involving compromised skin barrier function. Such diseases include blistering diseases of the skin, hereditary defects in skin barrier function, hyperproliferative conditions involving the skin, conditions associated with aging or damaged skin, immunological disorders involving the skin, among others.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 14, 2020
    Assignee: URGO US, INC.
    Inventors: Mark Sampson, Svetlana Panicheva, Cary Schockemoehl
  • Patent number: 10528782
    Abstract: One method for estimating the extracorporeal blood volume in a portion of a physical sample includes: extracting a feature from a portion of an image of the sample; tagging the portion of the image of the sample with a blood volume indicator according to the extracted feature; and estimating the extracorporeal blood volume in at least the portion of the physical sample, associated with the portion of the image of the sample, according to the blood volume indicator.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 7, 2020
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Kevin Miller, Ali Zandifar
  • Patent number: 10485957
    Abstract: Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: November 26, 2019
    Assignee: Muffin Incorporated
    Inventors: Neal E. Fearnot, Peter S. McKinnis, Kem Hawkins
  • Patent number: 10485919
    Abstract: A kit to facilitate creation of and compliance with a personalized injection site rotation plan includes a plurality of disposable injection devices adapted for giving an injection of a medication to a patient in need thereof, each disposable injection device having a permanent, distinctive mark that may be the same as or different from the distinctive mark on other disposable injection devices in the kit; and a plurality of user-defined association tools, wherein for each unique distinctive mark on a disposable injection device, at least one user-defined association tool has a distinctive mark that corresponds to the unique distinctive mark.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 26, 2019
    Assignee: Montmed Inc.
    Inventors: Amir Farzam, Allison Olenginski
  • Patent number: 10478532
    Abstract: A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 19, 2019
    Assignee: Alcon Research, Ltd.
    Inventors: Glenn Robert Sussman, Mikhail Boukhny, John Morgan Bourne
  • Patent number: 10473062
    Abstract: A fuel vapor processing device includes a three-way valve having a common valve chamber in which a first valve body, a second valve body, and a third valve body are housed. A single pressure sensor is provided in the common valve chamber. The first valve body enables communication between the common valve chamber and a first valve chamber. The second valve body enables communication between the common valve chamber and a second valve chamber communicating with an inside of the canister. The third valve body enables communication between the common valve chamber and a third valve chamber communicating with an inside of a fuel tank. An ECU controls the three-way valve and a switching valve, and controls driving of a pump to perform fuel vapor leak diagnosis for the fuel tank and the canister, based on a detection value detected by the pressure sensor.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 12, 2019
    Assignee: DENSO CORPORATION
    Inventors: Keiichirou Ishihara, Tomohiro Itoh
  • Patent number: 10441778
    Abstract: An implantable medical device for providing phototherapy to a patient's brain is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient. A light path is attached to the housing. The implantable medical device is configured to be positioned between a patient's skull and scalp with the light path extending into the patient's brain, such that light from the light source can irradiate a target position within the patient's brain. The implantable medical device is powered and controlled by an implantable pulse generator (IPG) that may be implanted into a patient's tissue remotely from the device and connected to the device by wire leads.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 15, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: William G. Orinski
  • Patent number: 10371775
    Abstract: This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a method includes using a medical fluid pump of a medical fluid pumping machine, such as a hemodialysis machine, to deliver medical fluid to a first portion of a cartridge that is positioned within a magnetic field, exciting atoms in the medical fluid in the first portion of the cartridge by applying radio frequency energy to the medical fluid in the first portion of the cartridge, receiving radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge, and determining a concentration of a substance in the medical fluid based on the received radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: August 6, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Ross Peter Jones, Martin Joseph Crnkovich, Fei Wang, Thomas Irvin Folden, Lynn Jensen, Shashikant Dattatraya Kalaskar
  • Patent number: 10315020
    Abstract: A device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame. The active substance dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device includes a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: June 11, 2019
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Uwe Wortmann, Roman Hadaschik, Michael Horstmann
  • Patent number: 10300195
    Abstract: A method of operating an infusion device that includes the steps of actuating a fluid transfer device, which is configured to deliver a predetermined volume during each actuation, in accordance with a delivery profile that includes a plurality of fluid transfer device actuations, determining, based on sensed pressure, whether an actual volume delivered during a fluid transfer device actuation is the predetermined volume, and adjusting the number of actuations in the delivery profile in response to the actual volume delivered differing from the predetermined volume.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 28, 2019
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Christian M. Merot, Pedrum Minaie
  • Patent number: 10265341
    Abstract: The present invention relates to a hydrogel formulation containing an oxidative reduction potential (ORP) water solution and a gelling agent. The invention further provides a method for treating or preventing a condition in a patient comprising topically administering to a patient a therapeutically effective amount of a hydrogel formulation comprising an oxidative reductive potential solution and a gelling agent. A method for promoting wound healing in a patient is also provided.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 23, 2019
    Assignee: Sonoma Pharmaceuticals, Inc.
    Inventor: Robert Northey
  • Patent number: 10252077
    Abstract: A method of irradiating spinal tissue with red/NIR light, comprising: inserting a cannulated device defining a bore into the spinal column, wherein the bore contains an optically transparent substrate adapted to emit red/NIR light, and transmitting NIR/red light through the substrate to irradiate tissue within the spinal column.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: April 9, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mohamed Attawia, Thomas M DiMauro, Jeffrey K Sutton
  • Patent number: 10245441
    Abstract: An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: April 2, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Brad C. Tischendorf, Gordon O. Munns, Christian S. Nielsen, John D. Norton, Markus W. Reiterer, Andrew J. Thom, Kunal J. Paralikar
  • Patent number: 10245443
    Abstract: Disclosed herein is a method of treating a patient that involves injecting a flowable material into a cancellous bone region of a bone, wherein the material is adapted to facilitate tissue regeneration, and then irradiating the cancellous bone region with an effective amount of NIR/red light. The irradiation may be carried out from a light source located inside the bone. The light may enter the bone via a transmitter located underneath the skin of the patient.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: April 2, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mohamed Attawia, Thomas M DiMauro, Jeffrey K Sutton
  • Patent number: 10238890
    Abstract: Methods and apparatus for the inactivation of infectious agents in, on or around a catheter residing in a patient's body cavity. The method comprises a coupling adapter for facilitating the transmission of non-ultraviolet sterilizing electromagnetic radiation (EMR) substantially axially along an optical element into the catheter body. Through delivery of the sterilizing EMR to particular areas of highest infection, the present disclosure is able to inactivate the major sources of infection in catheters.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: March 26, 2019
    Assignee: Light Line Medical, Inc.
    Inventors: Nathaniel L. Rhodes, Adam E. Bracken, Martin de la Presa, Ahrash E. Poursaid, Ryan R. Coil, Mitchell D. Barneck, James P. Allen
  • Patent number: 10201647
    Abstract: Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: February 12, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Michael G. Norris, Jacob W. Scarpaci, Robert J. Bryant, Jr., Geoffrey P. Spencer, David J. Hibbard, James D. Dale, John M. Kerwin, Andrew S. Coll, David A. Beavers, David W. McGill, Simon C. Helmore, David B. Doherty, Edgar J. Bolton, Jinsun Yoo, Paul G. Girouard, Daniel S. Karol, Daniel B. Singer, Joseph P. Rushlow
  • Patent number: 10159825
    Abstract: A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 25, 2018
    Assignee: ZipLine Medical, Inc.
    Inventors: Amir Belson, Brian Beckey, James J. Leary
  • Patent number: 10105518
    Abstract: A neuro-surgery assembly includes a neuro-catheter slidably received over a wire guide. The wire guide includes an inner tube positioned within an elongate hollow tube that includes a pattern of openings at its distal segment to provide an atraumatic tip for reaching sensitive locations in a brain. The wire guide is changeable between a stiff condition in which the inner tube is pressurized and a soft condition in which the inner tube is depressurized. The user may switch between the stiff and soft conditions to negotiate the tortuous pathway to a brain treatment site without a need to swap out to a different wire guide to support advancement of the neuro-catheter.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: October 23, 2018
    Assignee: Cook Medical Technologies LLC
    Inventor: Palle Munk Hansen
  • Patent number: 10016618
    Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 10, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Alan D. Hirschman, Arthur E. Uber, III, David M. Reilly, John F. Kalafut, Frederick W. Trombley, III, Steven J. Remis, Scott Griffith, Douglas Descalzi, Richard Dewit, David M. Griffiths, Marc A. Mabie, Mark Trocki
  • Patent number: 9775798
    Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 3, 2017
    Assignee: REVEN PHARMACEUTICALS, INC.
    Inventors: Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
  • Patent number: 9679879
    Abstract: Provided is a LED light-emitting device including: a carrier, which is a transparent body, and on a carrying surface of which conductors are provided; a plurality of LED chips, which are electrically connected to the conductors by way of eutectic bonding, so as to realize electrical connection among the plurality of LED chips; an encapsulation structural member, which is a transparent body and encapsulates on the periphery of the carrier and the LED chips; and a pair of electrodes, wherein positive electrode/negative electrodes in the pair of electrodes are electrically connected to the LED chips located at the most upstream/most downstream of a current transmission in the plurality of LED chips by means of the conductors, and extend to the outside of the encapsulation structural member.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: June 13, 2017
    Assignees: Zhejiang Zhongzhou Lighting Technology Co., Ltd.
    Inventor: Xiaobiao Zhu
  • Patent number: 9649131
    Abstract: The present application relates to a microdermabrasion device (1). The device has a suction path (11) along which skin fragments removed by the device are drawn, and a detection unit (3) configured to determine one or more characteristics of skin fragments drawn along the suction path. The detection unit is configured to determine the depth of abrasion performed by the device based on the one or more characteristics of skin fragments drawn along the suction path. The present application also relates to a method of determining the operating depth of abrasion of a microdermabrasion device.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: May 16, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Linda Goverdina Maria Beijens, Martin Jurna, Antonius Maarten Nuijs, Maria Angelina Josepha Grootel-Rensen, Caecilia Hendrina Theodora Chlon
  • Patent number: 9549851
    Abstract: A surgical hand piece comprises a shell, a channel having an irrigation conduit, and a sensor housing. The channel is coupled to the shell such that the proximal end of the channel is located at the proximal end of the shell and the distal end of the channel is located near the distal end of the shell. The sensor housing has an irrigation path extending through it. The sensor housing has a seal interface on one end. The seal interface end of the sensor housing is coupled to the proximal end of the channel such that the irrigation conduit of the channel is fluidly coupled to the irrigation path of the sensor housing.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 24, 2017
    Assignee: Novartis AG
    Inventors: James Yong Chon, Robert Stephen Maurer, Jr., Satish Yalamanchili
  • Patent number: 9461421
    Abstract: A catheter assembly includes a catheter handle having a handle body defining a bore and having a proximal part and a distal end. A catheter sheath has a proximal part received in the bore of the handle body, the catheter sheath projecting from the distal end of the catheter handle and the proximal part of the catheter sheath carrying a series of spaced electrically conductive members. Each conductive member is electrically connected to a conductor extending in the catheter sheath from the proximal part towards a distal end of the catheter sheath. A carrier is arranged in the bore of the catheter handle, the carrier carrying a series of spaced electrical contacts with each contact being configured to make electrical contact with one of the electrically conductive members of the catheter sheath.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: October 4, 2016
    Assignee: CathRX LTD
    Inventor: David Ogle
  • Patent number: 9089650
    Abstract: An assembly including a drug delivery device and a monitoring device adapted to detect an action taking place in the drug delivery device. The drug delivery device including a main portion having a drug expelling mechanism for expelling drug from the reservoir through an outlet, a housing in which at least a portion of the expelling mechanism is arranged, and a member able to attach a cover to the drug delivery device. The cover is adapted to cover the outlet when mounted. The monitoring device includes a housing portion, a member for detecting an action taking place in the drug delivery device, and at least one member adapted to engage a member present on the main portion. By this arrangement the monitoring device can be placed in a pre-determined position relative to the main portion, allowing efficient transmission of information between the monitoring device and the main portion.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: July 28, 2015
    Assignee: Novo Nordisk A/S
    Inventors: Ole Christian Nielsen, John Østergaard Madsen