Abstract: A system and method are provided for performing hyperbaric oxygen therapy treatment to stop a cascading effect of an inflammatory response to an injury. Hyperbaric oxygen therapy is performed during the inflammation to suppress the release of cytokines, most preferably, within 72 hours of sustaining the injury. Subject to evaluation of the patient, at least a second hyperbaric oxygen therapy treatment is performed.

Abstract: A system comprising: (a) a sheath configured to receive all or a portion of an endoscope; (b) an irrigation line connecting the sheath to an irrigation source; (c) a suction line connecting the sheath to a suction sources, and (d) a control module located between the sheath, and the irrigation source and the suction source and controls flow of irrigation fluid from the irrigation source to the sheath and movement of suction between the suction source and the sheath; wherein the irrigation source is connected to a resilient reservoir that is located within the control module and movement of the control module compresses the resilient reservoir moving irrigation fluid from the resilient reservoir to the sheath so that the irrigation fluid assists in cleaning the endoscope, and wherein the control module includes a valve and compression of the resilient reservoir initiates movement of the valve so that the valve opens and suction from the suction line is applied to the sheath.

Abstract: Methods for treating acne vulgaris include providing a solution having a peroxide compound, the solution having an antimicrobial effect for reducing bacteria that cause acne vulgaris; topically administering a therapeutically effective amount of the solution to the patient; and once administered, exposing the solution to a wavelength of light that creates a synergistic antimicrobial effect with the solution and enhances the antimicrobial effect of the solution, thereby further reducing or eliminating the bacteria that cause acne vulgaris. The methods may decrease lesions and associated inflammation in patients infected with acne vulgaris.

Abstract: An endoluminal access system for accessing a body lumen includes a guide track which, when in an operative position, extends through a body lumen to a desired location therewithin and a modular device selectively coupleable to the guide track, the modular device including a drive mechanism for engaging the guide track to move the modular device along the guide track within the body lumen. A method of resecting tissue from a site within a body includes the steps of inserting a guide track to a desired location within the body lumen, coupling a modular device to a proximal end of the guide track and actuating a motor mounted within the modular device to drive the modular device distally along the guide track to the site, drawing tissue at the site into the modular device in combination with the steps of coupling together a portion of tissue adjacent to the site, resecting the tissue from the site and actuating the motor to drive the modular device proximally to withdraw the modular device from the body lumen.

Abstract: The present disclosure relates to adapter assemblies for use with and to electrically and mechanically interconnect electromechanical surgical devices and surgical loading units, and to surgical systems including hand held electromechanical surgical devices and adapter assemblies for connecting surgical loading units to the hand held electromechanical surgical devices.

Abstract: There is provided an insufflation system and an insufflation apparatus which can prevent a pressure inside a lumen from rapidly increasing and can achieve operability matched to a sense of an operator. When the operator operates an air/water supply button of the endoscope, the gas is insufflated into a gastrointestinal tract of a patient through an internal conduit of the endoscope (manual insufflation). Meanwhile, the insufflation apparatus is connected to an insertion assisting tool which guides the endoscope into the gastrointestinal tract. When the insufflation apparatus automatically performs insufflation, the gas is intermittently insufflated into the gastrointestinal tract of the patient so as to maintain the pressure inside the gastrointestinal tract at the set pressure (automatic insufflation). The average flow rate of the gas in the automatic insufflation is set to be less than or equal to the insufflation flow rate in the manual insufflation.

Abstract: A device for rapidly sanitizing a surface is described. The device has an enclosure having an opening adapted to insert a surface, and an interior; a liquid nitric oxide solution applicator; and an absorbent material. The liquid nitric oxide solution applicator is in fluid communication with the interior of the enclosure and is adapted to apply liquid nitric oxide solution onto the surface when the surface is positioned within the enclosure. A method of rapidly sanitizing a surface is described. The devices and methods provided herein may be implemented to sanitize the surface of any body part or item that may be placed within the device. An infectious agent on the surface may be killed; i.e., the surface is disinfected. Non-limiting applications of the devices and methods include preventing nosocomial infections or food contamination, sanitizing household items, and implementing sanitizing procedures to comply with FDA Good Manufacturing Practices.

Abstract: Apparatus and a method for the provision of TNP therapy to a wound are described, the apparatus comprising: a sealing membrane (504) for covering a wound to form a wound cavity (500); one end of an aspirant conduit (522) operably associated with the wound cavity, vacuum means (524) provided at a distal end of the aspirant conduit for applying a vacuum to the wound cavity; and, air bleed means (510) in fluid communication with the wound cavity. Various embodiments of air bleed port members are also described.

Abstract: There are provided pressurized surgical instruments for use in pressurized surgical environments. The pressurized surgical instruments include pressurizing systems for maintaining a neutral or positive pressure flow within the surgical instrument during use. The pressurizing systems include a primary sensor for detecting the pressure of the surgical environment and a pressurizing mechanism for balancing the pressure of the surgical instrument with the surgical environment. The pressurizing mechanism includes a controller to receive and compare the signal sent from the primary sensor to the ambient or internal instrument pressure and a pressure delivery system to provide positive pressure to the interior of the surgical instrument in response to a signal received from the controller. The sources of pressure for the pressure delivery systems may be external or self contained within the surgical instrument.

Abstract: Devices and methods for sealing and cutting tissue are provided. In one exemplary embodiment, a surgical device includes a pair of opposed, pivoting jaws, a cutting blade assembly slidably coupled to the jaws, and a biasing member disposed in a portion of the cutting blade assembly and configured to be received by a track formed between proximal ends of the jaws. The cutting blade assembly can be operative to open and close the jaws, and the biasing member can be configured to be disposed at a location in the track that applies a spring bias to a proximal end of at least one of the jaws. The spring bias in turn increases a compressive force applied by distal ends of the jaws, which in turn can maintain or increase a force applied to tissue disposed between the jaws. Other devices and methods for sealing and cutting tissue are also provided.

Abstract: The present invention provides a topical oxygen therapy system for treating chronic non-healing wounds. The system is configured to be extremely portable, allowing patients to be completely ambulatory during treatment. The topical oxygen therapy system includes an oxygen source and a wound dressing capsule. The oxygen source includes a miniature compressed oxygen cylinder and a miniature pressure regulator that delivers oxygen through an outlet tube to the interior of the wound dressing capsule. The oxygen source may be attached directly to or integrated into the wound dressing capsule. Alternatively, the oxygen source and wound dressing capsule may be separate modules connected by a flexible tube.

Abstract: The invention is to provide a pressurized gas mist bathing system, ensuring hygiene and reduction in costs, by making only one part of the system disposable.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: Provided is a hairdressing appliance, which includes a portable treatment unit provided with a gripping device and a heat and steam treatment system configured for heating hair and for applying steam to this hair, a base remote from the portable treatment unit, and connection device between the base and the portable treatment unit configured for supplying the portable treatment unit at least with electricity from the base. The hairdressing appliance includes a circuit board for controlling the treatment system arranged in the base and a system of communication between the control circuit board and the treatment system. The hairdressing appliance enables, for example, the straightening, curling, or crimping of hair and chiefly aims to reduce the weight and the bulk of the portable treatment unit so as to make it easier to handle during styling.

Abstract: An animal euthanasia device includes a chamber with an opening through which a partitioned cage may be wheeled. A pivotally attached door seals the opening using fixed edge seals and an inflatable door threshold seal. A latch secures the door, once closed. After a sensor verifies door closure, an electro-magnetic lock prevents inadvertent door opening during the process, which may be automated using a programmable logic controller (PLC). The PLC coordinates actuation of a fan and damper within an air exhaust opening, a fan and a damper within an exhaust gas opening, and a damper within a fresh air inlet opening, and also triggers a solenoid valve that controls flow of euthanizing gas into the chamber. A keyed selector switch controls power to the device to initiate the automated process, which is monitored using oxygen sensors, and CO2 flow and pressure sensors, and is reported on a human machine interface.

Abstract: Apparatus and Methods for protecting a patient from surgical site infection from airborne microbes during surgery. A sterile gas flow conditioning emitter for affixation onto an anatomical surface of a patient adjacent a site of incision is anatomically shape conforming for attaching a unidirectional coherent non-turbulent flow field of sterile gas substantially anatomically levelly on that anatomical surface and flowing the flow field in the direction of that site while essentially preventing ambient airborne particles from entering the interior of the flow field under the emitter to maintain the gas essentially sterile during passage over the site.

Abstract: Provided are a gas mist pressure bathing method and a gas mist pressure bathing system that improve the efficiency of absorbing a gas mist from the skin and mucous membranes of a living body. The gas mist pressure bathing method is provided with a first step, a second step and a third step. The first step involves supplying a gas mist and gas for a predetermined time to at least a first cover 51 of a living body cover member 50 having said first cover 51 and a second cover 55 positioned outside of the first cover 51, the inside of said second cover 55 being substantially sealed; covering the skin and mucous membranes of the living body; and forming a space wherein the gas mist and gas supplied by a gas mist generating means 30 are sealed. The second step involves discharging the gas mist and gas from the first cover 51 and/or the second cover 55.

Abstract: A uretero-renoscope includes a shaft, on whose distal end an instrument head is arranged. The instrument head tapers continuously in the distal direction.

Abstract: A system and method for use in surgical procedures. The system includes an endoscope, an imaging device coupled to the endoscope, an imaging processor coupled to the imaging device, and at least one management system coupled to the imaging processor, in which a function of the management system is automatically adjusted upon receipt of a communication from the imaging processor.

Abstract: A method and apparatus for treating gas for delivery into a body cavity, body space or body surface of an animal. The apparatus comprises a housing defining a chamber having an entry port and an exit port. One or more agents are released into the gas stream that flows through the chamber so that the gas stream carries the agent to the animal. Also shown, for use with, or without, the chamber, is an agent chamber adapted to be coupled to at least one structure defining at least one fluid flow path extending at least a portion of the distance between an insufflation device and the body cavity, body space or body surface.

Abstract: Lightweight, small, portable devices and methods are disclosed that provide oxygen-enriched air using an ultra rapid adsorption cycle based on advanced molecular sieve materials.

Abstract: A system for the administration of modified plasma to a subject, including: (a) a non thermal plasma (NTP) emitting source for emitting a plasma beam; (b) a plasma coupling mechanism (PCM) with a plasma beam dish having at least one opening for the passage of the plasma beam; the plasma beam dish having a first surface and a second opposite surface. The first surface of the plasma beam dish includes: at least one coupling element selected from the group consisting of: (1) at least one ferroelectric element for providing the field; (2) at least one ferromagnetic element for providing the field; (3) at least one piezoelectric element for providing the field; and (4) at least one piezomagnetic element for providing the field. The system additionally includes at least one reflecting element configured to focus the NTP beam, thereby providing the modified plasma.

Abstract: An oxygen distributor (1) positionable, in use, in a wound for supplying oxygen to the wound has an oxygen delivery area (17) for, in use, receiving a supply of oxygen. At least one tube (19A) extends from the oxygen delivery area, having a tube wall with an oxygen-permeable, liquid-impermeable section. Oxygen delivered to the oxygen delivery area can flow away from the oxygen delivery area along the, or each, tube.

Abstract: Exemplary methods of opening pores and moving molecules into tissue comprising, applying plasma to the surface of tissue and applying a carrier including one or more molecules to the surface of the tissue are disclosed herein.

Abstract: A nitric oxide delivery device includes a housing that is permeable to nitric oxide. A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A conductive lead is electrically connected to the working electrode and extends outside of the housing. A reference electrode and/or a counter electrode is electrically isolated from the working electrode. The reference electrode and/or the counter electrode has a first portion that is inside of the housing and a second conductive portion that is outside of the housing. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.

Abstract: In accordance with at least one exemplary embodiment, a syringe device, a method and a system for delivering a therapeutic amount of ozone are disclosed. A sterility case can enclose a syringe portion and can maintain sterility while the syringe device is interfaced to an ozone generator. A valvably-controlled fluid channel can extend from a barrel of the syringe portion through the case. Conducting elements can be attached to the case and can breach the case. The conductive elements can be connected to electrodes. The electrodes can be attached to the syringe portion. The syringe portion can be filled with oxygen gas via the valvably-controlled fluid channel. An electric current can be provided to the conductive elements from the ozone generator resulting in a corona discharge from at least one of the electrodes. The therapeutic amount of ozone can be produced from the oxygen gas and the syringe portion delivered into a sterile field without compromise.

Abstract: A trocar system for providing access across a body wall includes a trocar and an anchor provided in the form of a first helix. The anchor is adapted for placement in an operative position wherein the anchor extends at least partially through the body wall. A second helix formed on the trocar is size and configured to engage the first helix of the anchor so that rotation of the trocar relative to the anchor moves the second helix along the first helix. In this manner, the trocar is drawn into the anchor as it moves into the body wall. A proximal force applied to the anchor resists tenting of the abdominal wall. The anchor also holds the layers of the body wall together thereby resisting peritoneal separation.

Abstract: Systems and method comprise forming a cavity adjacent a wound. Formation of the cavity comprises applying a bandage to an area adjacent the wound. A topical hyperbaric oxygen emulsion (THOE) is applied to the wound, and the THOE comprises a perfluorocarbon (PFC). The cavity holds a pressure when the THOE is applied, wherein the pressure increases oxygen saturation of the wound and reduces oxygen diffusion from the THOE.

Abstract: A controller is operable to selectively supply gas to, and evacuate gas from, regions of a hyperbaric wound treatment chamber. The controller operates to inflate a passage or rib of the device to provide that the device is made sufficiently rigid for inserting a limb therethrough, and inflate an inflatable cuff to create a seal against the limb. The controller also operates to evacuate ambient air trapped within the chamber, and optionally partially evacuate the passage or rib, after the seal is created by the inflatable cuff, and then introduce oxygen into the chamber, and optionally inflate the passage or rib. The cuff, when inflated and creating a seal against a limb, optionally is at least partially within the chamber, and the treatment gas is supplied to the chamber to maintain the seal of the cuff against the limb.

Abstract: A wound injector apparatus is described. The wound injector includes a clotting factor, an expandable material, a thermal agent, a chamber, and a nozzle. At least one chamber houses the clotting factor, the expandable factor and the thermal agent. Additionally, at least one nozzle is configured to discharge at least one of the clotting factor, the expandable material, and the thermal agent.

Abstract: Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage.

Abstract: The pneumatic system for intussusception treatment, i.e., invagination of a segment of the intestine into an adjacent segment, includes a pressurized gas supply connected to a series of filters, valves, regulators, and sensors connected to a rectal insertion tube to introduce gas at moderate pressure into the intestine of the patient. A computerized control and monitoring subsystem is included. The system preferably includes a heating system to warm the gas as desired. The system also preferably includes an exhaust portion to relieve internal intestinal pressure as required or desired. The exhaust portion of the system preferably includes a filter to absorb undesirable fecal odors that accompany the exhausted gas. At least the rectal insertion tube and the odor filter may be separable from the remainder of the system for convenient disposal. An alarm may be provided to alert the doctor or medical professional of conditions other than normal.

Abstract: A vessel harvesting apparatus is provided for removing a vessel from a patient. An endoscopic instrument has a distal end with a vessel harvesting tip and has a proximal end with a handle. The endoscopic instrument has an insufflation channel adapted to receive an insufflation gas from a regulated source at the proximal end. The insufflation channel has an outlet at the distal end adapted to expel the insufflation gas subcutaneously in the patient. A damping device has a flexible bladder with an inside space in fluid communication with the insufflation channel. The inside space has a volume that varies between a rest volume and an inflated volume in response to an amount of insufflation gas flowing to or from the flexible bladder.

Abstract: A device uses cold plasma to treat cancerous tumors. The device has a gas supply tube with a delivery end. The gas supply tube is configured to carry a gas to the delivery end. A syringe is provided having an opening. The syringe is connected to the supply tube and configured to carry the gas to the opening. A first electrode is positioned inside said syringe, and a second electrode is positioned adjacent to the opening. The first and second electrodes excite the gas to enter a cold plasma state prior to being discharged from the opening of the syringe. An endoscopic tube can be used instead of the syringe. An exhaust tube can be provided to remove gas introduced into the body cavity by the cold plasma jet.

Abstract: The invention is to provide a gas mist pressure bath device which enables to cause efficiently absorb a gas mist into a skin or mucous membrane of a living-body, and attains to be compact and to lower cost. The device 10 is to cause oxygen, carbon dioxide, or a mixed gas (called as “gas” hereafter) of oxygen and carbon dioxide at a density of not less than a predetermined value to contact the skin or mucous membrane of the living-body, and the device comprises a gas mist generating means 11 for generating and supplying a mist (called as “gas mist” hereafter) prepared by pulverizing and dissolving the gas and liquid, and a substantially bag shaped living-body cover member 21 for covering the living-body's skin or mucous membrane and sealing inside, and the gas mist is supplied into the living-body cover member in order to heighten internal pressure therein so that the gas mist is caused to contact the living-body's skin or mucous membrane at a pressure more than the predetermined value.

Abstract: Embodiments of the present invention are directed to various designs and packaging methods for a gas delivery device and materials for supplying one or more predetermined gases to a target area as well as to application specific opthamological embodiments. With regard to the gas delivery device, the device may include a reservoir, a gas diffusion portion for communicating gas from the reservoir and one or more predetermined gases at concentrations greater than atmospheric contained within the reservoir, wherein the device does not generate gas and may be packaged prior to use with the one or more predetermined gases.

Abstract: The present invention discloses a system for the administration of a plasma modified field (PMF) to a subject comprising: (a) a non thermal plasma (NTP) emitting source for emitting a plasma beam; (b) a plasma modified field coupling mechanism (PMFCM) comprising a plasma beam dish having at least one opening for the passage of said plasma beam; said plasma beam dish having a first surface and a second opposite surface; and (c) a controller for controlling said PMFCM. In a main aspect of the invention, said first surface of said plasma beam dish is mounted with: (i) at least one coupling element selected from the group consisting of: (1) at least one ferroelectric element for providing said field; (2) at least one ferromagnetic element for providing said field; (3) at least one piezoelectric element for providing said field; and (4) at least one piezomagnetic element for providing said field; and (ii) at least one reflecting element.

Abstract: A system for reduced scarring of wounds; said system comprising: means (1) for creating an enclosed volume (3) over a wound site (2). The system further comprises: means (6, 10, 11, 12) for actively reducing the oxygen concentration within the enclosed volume at the surface of the wound to a first oxygen concentration level while maintaining an environment within the enclosed volume which is healthy for wound healing, means (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14) for ensuring that the oxygen concentration of the gas composition of the gas within the enclosed volume at the surface of the wound is maintained below a second oxygen concentration level and above a third oxygen concentration level, and where said system is arranged such that said first, second and third oxygen concentration levels are between 1 and 16 volume percent.

Abstract: A device is provided for cooling intra nasally the brain of a patient, in particular of a patient suffering from cardiovascular emergency. The device comprises a pressurized gas container for containing a gas or a mixture of gases, and at least one cannula with a lumen, a proximal opening and at least one distal opening. The cannula is for introduction into the patient's nasopharynx. Upon operation, gas expands adiabatically upon exiting from the at least one cannula, thereby cools and provides a coolant effect on the nasopharynx and inside the nasal cavity.

Abstract: The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: A cover for gas mist pressure bath includes a living-body cover member having an extension part extending from substantially center part of the living-body cover member, an adhesive part adhering the cover member to the skin and the mucous membrane of the living-body, a gas mist supply port for introducing the gas mist into the cover member for gas mist pressure bath, an outlet for exhausting air, the gas mist or the mixed gas sealed in the cover member for the gas mist pressure bath and controlling amounts of the gas, a fixing member fixing the cover member on the living-body, including a pair of belts extending from an edge of the adhesive part and a pair of belt stoppers adjusting the pair of belts, and a constricting ring pressurizing an inside of the living-body cover member to carry out pressurization.

Abstract: The present invention relates to a negative pressure wound treatment system and methods for using such a system. Preferred embodiments of the invention facilitate treatment of the wound by delivering oxygen into the tissue in conjunction with the application of negative pressure.

Abstract: A syringe for treating facial wrinkles having a syringe cylinder, a needle body detachably mounted at the front end portion of the syringe cylinder and having a syringe needle disposed thereon, and a piston rod disposed inside the syringe cylinder for operating a piston is provided. The syringe includes: the syringe cylinder formed of a substantially thin tube having an inside diameter in a range of 2.0 mm to 7.0 mm; and an inflow check valve disposed at one side of the front end portion of the syringe cylinder so as to supply a predetermined quantity of gas to the interior of the syringe cylinder. The predetermined quantity of gas supplied through the inflow check valve to the interior of the syringe cylinder and a predetermined quantity of liquid filled into the syringe cylinder are injected in turn into the dermis of the skin, which is repeatedly carried out.

Abstract: A stable delivery system for the therapeutic release and application of nitric oxide to a patient suffering from a cutaneous injury or wound includes a S-nitrosothiol and transition element nanoparticles. The transition metal nanoparticles are selected to react with the S-nitrosothiol to release and diffuse nitric oxide into the injury or wound.

Abstract: Apparatus and methods to treat skin defects include a pump with reservoirs for a pressurization gas and a fluid. Upon activation, the pump generates a gas introduced into the gas reservoir, a movable wall of which displaces a movable wall of a fluid source, thus dispensing the fluid into the dressing to spread throughout irrespective of orientation of the dressing, maintaining a transport fluid (e.g. carrier) in the dressing and in contact with a skin defect being treated. The dressing may have a distribution network, and multiple members, dispensing the fluid into the dressing and in contact with a skin defect being treated.

Abstract: A method for treating skin in a subject is disclosed. The method comprises the steps of administering a stem cell composition into a target body site in the subject by subcutaneous, intradermal or topical delivery, and contacting the target body site with a treatment device designed for introducing CO2 into subcutaneous tissue, wherein the CO2 and the stem cell composition are provided in an amount effective for treating a skin-related disorder or improving the condition of skin. Also disclosed is a method for generating induced pluripotent stem cells (iPSCs) in a subject.

Abstract: One aspect of the invention is an apparatus including an alarm for alerting an operator to recharge a humidifier, wherein such alarm is generated other than through the use of a humidity sensor. In one embodiment the total work performed during heating and hydrating an insufflation gas is measured and an alarm generated when the total work performed exceeds a particular threshold. In another embodiment, a flow meter is used to measure the total flow of insufflation gas so that when the total flow of insufflation gas reaches a predetermined level an alarm is activated.

Abstract: The present invention recognizes that there exists a need for the treatment diseases, disorders and conditions that cause or are related to bad breath in general. The present invention provides devices and methods to address this need. A first aspect of the present invention is an oral device for a subject. A second aspect of the present invention is a method of treating a subject for a disease, disorder, condition, or a combination thereof, of the oral cavity with a device of the present invention. A third aspect of the present invention is a method of treating a subject for a disease, disorder, condition, or a combination thereof, of the oral cavity.

Abstract: Provided herein are systems and methods for maintaining breast or udder health. The systems include a first container comprising a top and a bottom, one or more cups attached to the top of the container and a first temperature-controlling element for providing vapor from the container to a breast or udder via the cup.

Abstract: A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.