Abstract: Method of dissolving/mixing of a concentrate in/with a fluid in a multi-chamber bag and a method for the production of a medical fluid, in particular a dialysis fluid, in a multi-chamber bag. Moreover, the multi-chamber bag itself is disclosed. In all embodiments, at least two different concentrates can be included separately in powder form, liquid form or semi-liquid slurry form for dissolution in a fluid in the multi-chamber bag. In addition, the use of the multi-chamber bag in haemodialysis or peritoneal dialysis or a haemodialysis or peritoneal dialysis device, in particular as a container for a dialysis fluid in a haemodialysis or peritoneal dialysis device, is described.

Abstract: The present invention relates to a method for adjusting a continuous dialysate volume flow in a dialysis machine with at least two discontinuous pumps and a controller for generating a desired volume flow of the dialysate. In accordance with the invention, for generating a rather continuous, highly constant dialysate volume flow the energy for driving the pumps is set to be constant with a value determined corresponding to the pump-time volume of the respective pump and the delivered volume. The invention also relates to a dialysis machine for carrying out the aforementioned method.

Abstract: A peritoneal dialysis system includes: (i) a fluid cassette including diaphragm operated first and second pump chambers; (ii) a first pressure sensor operable with the first pump chamber; (iii) a second pressure sensor operable with the second pump chamber; and (iv) a to-patient port of the cassette in fluid communication with the first and second pump chambers, wherein the first pressure sensor is located between the first pump chamber and the to-patient port and the second pressure sensor is located between the second pump chamber and the to-patient port.

Abstract: This invention relates to a method for the determination of gas in a fluid, wherein the mixture of gas and fluid both is delivered by a pump and is subjected to a change in volume and pressure, operating parameters of the pump, which represents the change in volume and pressure, are detected, and from the operating parameters of the pump the gas content is determined in consideration of a system compressibility, wherein the system compressibility in the pumping device filled with gas is determined by sequence of process steps. The invention furthermore relates to an apparatus for performing this method into a dialysis machine which contains a corresponding apparatus.

Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.

Abstract: A peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine including a logic implementer and a wireless interface receiver. The system also includes at least one of a scale or a blood pressure monitor including a wireless interface transmitter. The scale or blood pressure monitor is operable to send at least one of patient blood pressure data and patient weight data wirelessly, respectively, to the wireless interface receiver. The logic implementer is configured to store the patient blood pressure data or patient weight data. A server computer is configured to communicate with the logic implementer to receive the stored at least one patient blood pressure data and patient weight data.

Abstract: A peritoneal dialysis machine includes: (i) a housing; (ii) an actuator carried by the housing so as to be able to interact with a peritoneal dialysis fluid carrying disposable; (iii) at least one heating element carried by the housing; (iv) a heater pan providing an upper surface of the housing, the heater pan cooperating with the at least one heater element to provide heat to a container of peritoneal dialysis fluid placed onto the heater pan, the container being part of or in communication with the peritoneal dialysis fluid carrying disposable; and (iv) a weight sensor cooperating with the heater pan to sense the weight of the peritoneal dialysis fluid located within the container.

Abstract: Artificial kidney for gradual, and at least semi-continuous, blood treatment, wherein a blood stream is fed from a body of a living human or animal being into the artificial kidney, where anticoagulation is first effected, blood cells and molecules of large and medium molecular weight, such as proteins, are then primarily separated from plasma and fed back to the blood stream, regulating a water and salt balance by diverting excess plasma water and further removing from the blood stream, plasma or plasma water accumulated and toxic substances, by removal of specific electrolytes and waste products and wherein purified or partially purified plasma and plasma water is being carried back to the blood tract of the body.

Abstract: A peritoneal dialysis machine includes an enclosure; dialysate pump located within the enclosure; a graphical user interface allowing a patient to program a treatment including at least one patient fill performed by the dialysate pump, at least one dwell, and at least one drain performed by the dialysate pump; and the GUI further programmed to provide an alert when it is time to begin the treatment so as to complete the at least one patient fill, dwell and drain by a prescribed time.

Abstract: A peritoneal function testing apparatus tests the peritoneal function of a dialysis patient easily and with high accuracy. Standards of four kinetic parameters (CCr, Kt/V, MTACu, and MTACc) available in a definite dialysis guideline are computed in accordance with a relational expression, and a curve showing the relation between MTACu/c and the drained fluid volume is indicated in a graph together with the PET data of the patient which has been prepared separately. Thus, the peritoneal function can be evaluated based on the relative position of the patient's data and the curve showing the standard values in the graph.

Abstract: A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

Abstract: A method for making a peritoneal dialysis therapy machine having a tubing set includes: packaging an end of each of a plurality of the tubes of the set in a body; arranging the tubes according to a sequence of steps of a dialysis treatment set-up so that a user is urged to remove the tubes from the single body in a desired order; and configuring the body to plug connectors attached to each of the ends of the tubes.

Abstract: A peritoneal-based artificial kidney processes peritoneal fluid without need for additional fluids. Spent dialysate is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s). Alternatively, the spent dialysate is first processed in a sorbent assembly and then separated into the protein-rich and protein-free streams. Immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.

Abstract: This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a medical fluid pumping system includes a medical fluid pumping machine including a piston head that can be linearly displaced and a medical fluid cassette that can be secured to the medical fluid pumping machine. The medical fluid cassette includes a fastening member attached to a region of a flexible membrane overlying a fluid pump chamber, and the piston head is configured to be mechanically connected to the fastening member of the cassette.

Abstract: A split-tip catheter for placement within the vasculature of a patient and for use in hemodialysis or other suitable procedures is disclosed. In one embodiment, the split-tip catheter includes a catheter body that defines a first lumen and a second lumen. The catheter body further comprises a split distal region, including a venous segment and an arterial segment. The venous segment includes a recess extending proximally of a nose portion; and a lateral opening in fluid communication with the first lumen. The arterial segment also includes a lateral opening, is separate from the venous segment, and is removably seatable in the recess provided by the venous segment. In one embodiment, the distal region is un-split, but includes symmetrically opposed lateral openings, as well as distal openings, in communication with the first and second lumens for providing a functional stagger for blood flow in both forward and reverse catheter flow directions.

Abstract: A dialysis system instrument includes a dialysis instrument, a disposable pumping and valving cassette apparatus operable with pumping and valving actuators of the dialysis instrument, the disposable cassette including an electronic cell and electronics associated with the electronic cell, the electronics configured to determine an electrical property of a solution flowing through the electronic cell of the disposable apparatus.

Abstract: The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.

Abstract: A method and a system for regenerating a body fluid, such as a peritoneal dialysis fluid. The body fluid is removed into an extracorporeal circuit comprising an electrofilter for removing charged ions from the body fluid, a nanofilter for removing large molecules, such as Dextran 40, and a reverse osmosis filter for concentrating the body fluid, for producing a synthetic urine to be discarded. The removed ions and large molecules are returned to the patient together with pure water from the reverse osmosis filter through an ultrafilter.

Abstract: In one aspect, the invention provides methods and apparatus for delivering peritoneal dialysis (PD) solution (or other fluids), from a supply to a patient. A first pump, in fluid coupling with the supply, delivers PD solution from the supply to a “mesne” (or intermediate) measuring element, and generates signals indicative of a volume of that delivered PD solution. The mesne measuring element, in fluid coupling with the first pump, generates signals indicative of a volume of PD solution received from that pump. A second pump, fluidly coupled to the mesne measuring element, routes PD solution from the mesne measuring element for delivery to the patient.

Abstract: A medical fluid system includes a medical fluid pump; a container holding a fluid to be pumped by the medical fluid pump, the fluid at a first time having a first conductivity, the fluid at a second time having a second conductivity; and a radio frequency level sensor positioned in operable relation with the container, the radio frequency operation of the level sensor configured so as to be (i) indicative of a level of the fluid in the container and (ii) at least substantially independent of whether the fluid has the first conductivity or the second conductivity. The medical fluid system can determine the level of medical fluid by measuring the resistance, impedance or phase shift seen by the sensor.

Abstract: This disclosure relates to medical fluid delivery sets and related systems and methods. In some aspects of the invention, a medical fluid delivery set includes a syringe connected to a series of interconnected fluid lines. The syringe includes a medical fluid containment cylinder and a plunger assembly that can be axially moved relative to the medical fluid containment cylinder. The plunger assembly includes an inner plunger shaft including a seal that is slidably disposed within the medical fluid containment cylinder and an outer plunger shaft that at least partially surrounds the inner plunger shaft to form a space between an outer surface of the inner plunger shaft and an inner surface of the outer plunger shaft that is sized to receive a wall of the medical fluid containment cylinder therein.

Abstract: A portable, flexible peritoneal dialysis system is disclosed. The system includes a flexible harness, such as canvas or cloth, to mount a stiff housing with a heater for holding and heating fresh dialysis fluid. The harness includes straps or other suspending devices for holding a second, flexible housing for a drain bag for holding sent dialysis fluid. The upper portion of the system includes a hook and a load cell for suspending the remaining portions. The load cell is used to measure the weight of the apparatus. By keeping track of the weight and the changes, the quantity of fluid removed from the patient, spent dialysate, is tracked, as is fresh dialysate infused into the patient. An electronics or control portion controls heating of the fresh dialysate, and operation of pumps and valves for moving the dialysate. This portion also includes alarms and communications equipment.

Abstract: A dialysis system includes at least one pump actuator, a disposable cassette operable with the at least one pump actuator, a plurality of disposable cassette supply connections, and plurality of dialysis solution lines. Each of the plurality of solution lines is connected to a dialysis solution container. The system further includes an autoconnection mechanism configured to connect the plurality of supply connections to the plurality of dialysis solution lines. The system additionally includes an autoidentification system configured to automatically identify information associated with the plurality of dialysis solution lines to determine at least one of (i) dialysis solution type (ii) dialysis solution volume, or (iii) a number of the plurality of dialysis solution supply containers.

Abstract: The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

Abstract: Peritoneal dialysis systems are provided by the present disclosure. In a general embodiment, a peritoneal dialysis system includes a cycler, a disposable cassette operable with the cycler, a supply bag connected to the disposable cassette, a supply connector, a supply line extending from the disposable cassette, a patient connector in fluid communication with a patient's indwelling catheter, a device to connect the supply connector to the patient connector, and a housing around the device. The housing includes a plurality of ultraviolet (“UV”) light-emitting diodes (“LED's”) for directing energy towards at least one of the supply or patient connectors. The LED's are configured to deliver about 200 milliJoules in a period of about a minute.

Abstract: In some aspects, a method includes determining whether a universal serial bus (USB) peripheral device is connected to a USB monitoring device that is connected to a medical device and drawing power from the medical device. The medical device is configured for use in a medical procedure with a patient. The method also includes determining whether the USB peripheral device is drawing power from the medical device if the USB peripheral device is determined to be connected to the USB monitoring device.

Abstract: Apparatus for supporting an operator in operating a medical device, comprising a signaling device for signaling a necessary operation of a component to be operated of the medical device, preferably by emitting a signal from the component to be operated and/or by orienting a signal onto the component to be operated. Method for supporting an operator in operating a medical device, comprising the signaling of a necessary operation of a component to be operated of the medical device by emitting a signal from the component to be operated and/or by orienting a signal onto the component to be operated. Single-use item for a medical device, preferably a single-use item for the medical device, with a component to be operated by an operator, wherein the component to be operated comprises a signaling device for emitting an optical, acoustical, and/or haptical signal.

Abstract: The present invention relates to a membrane, in particular to a hollow fiber membrane comprising a membrane, comprising at least two layers, wherein the at least two layers each comprise at least one layer forming material comprising at least one polymer and the at least two layers differ from each other with respect to the layer forming material, wherein the at least two layers are at least partly covalently and delamination free bonded to each other. The present invention relates furthermore to a method of production of the said membrane as well as to its use.

Abstract: A multiple catheter assembly (100) including a first catheter (110) having a first proximal end region (112), a first distal end region (114) terminating in a first distal tip (116), and an outer surface (120) defining at least a first lumen (122) extending longitudinally therethrough between a first distal and a first proximal opening. The assembly (100) also includes a second catheter (130) having a second proximal end region (132), a second distal end region (134) terminating in a second distal tip (136), and a second outer surface (140) defining at least a second lumen (142) extending longitudinally therethrough between a second distal and a second proximal opening. The first (122) and second (142) lumens are independent from each other for facilitating simultaneous flow in opposite directions.

Abstract: Peritoneal dialysis connectors, connector sets, connector systems and methods are disclosed. In an embodiment, a connector includes, a body, a spike located at a first end of the body, a sealing ring sized to seal inside a female connector and located adjacent to the spike end, threads located adjacent to the sealing ring, and at least one barbed ring located adjacent to the threads at a second end of the body. The at least one barbed ring is configured to seal the second end of the body to a tube.

Abstract: A medical fluid delivery cassette configured for use with a medical fluid pumping system. The cassette includes a base, a membrane attached to the base, and an adhesive disposed on a portion of the membrane overlying a fluid pump chamber of the cassette. The portion of the membrane overlying the fluid pump chamber is moveable such that the volume of the fluid pump chamber can be changed.

Abstract: In one embodiment of the invention, a robotic surgical instrument is provided for the control of flows of one or more fluids into and out of a surgical site. The robotic surgical instrument may include a housing, a flow control system, a hollow tube, and one or more hose fittings. The housing to couple the instrument to a robotic arm. The flow control system mounted in the housing includes one or more controlled valves to control the flow of one or more fluids. The hollow tube has a first end mounted in the housing coupled to the flow control system. A second end of the hollow tube has one or more openings to allow the flow of fluids into and out of the surgical site. The hose fittings have a first end coupled to the flow control system and a second end to couple to hoses.

Abstract: A peritoneal dialysis system includes a logic implementer configured to: (i) generate a number of peritoneal dialysis therapy regimens that meet at least one therapy target input; (ii) accept a filter input; and (iii) filter the generated therapy regimens according to the filter input to refine the number of therapy regimens available for selection.

Abstract: A peritoneal dialysis machine includes: (i) a supply bag; (ii) an apparatus configured to support the supply bag, the supply bag located above the peritoneal cavity of a patient; (iii) a vacuum source; (iv) a patient line configured to be connected to the patient; (v) a drain line configured to be connected to a drain; and (vi) a logic implementor configured to enable (a) fresh dialysate to be gravity fed from the supply bag through the patient line to the peritoneal cavity during a fill cycle and (b) the vacuum source to cause spent dialysate to be pulled from the peritoneal cavity through the drain line to the drain during a drain cycle.

Abstract: Fluid removal systems and methods for removing fluid from a tissue site are presented. The system includes a semi-permeable inbound conduit, which is fluidly coupled to a treatment-fluid delivery unit, for placement proximate to the tissue site, and a semi-permeable outbound conduit, which is fluidly coupled to the inbound conduit and to a treatment-fluid collector, for placement proximate to the tissue site of a patient. The treatment-fluid collector receives a treatment fluid and a recruited fluid from the tissue site. A recruited-fluid determination unit may be coupled to the treatment-fluid collector to determine a volume of fluid recruited from the patient. The treatment fluid is any fluid (including a gas) that pulls fluid from the interstitial and intracellular space. A reduced-pressure treatment subsystem may also be included, among other things, for removing ascites and other fluids from a body cavity.

Abstract: There are many medical situations that require removal of fluid from a patient. There are many ways to remove the fluid but many of these situations have not been solved. Herein, inventions are disclosed that generate osmotic pressure that can be used to remove these fluids very effectively, a technique which requires no harsh suction or pumping. One embodiment involves implanting a reservoir that has a semipermeable membrane sidewall. The reservoir contains trapped osmotic solutes that can not pass out through the membrane. But fluid from the patient can flow in. The osmotic pressure from the trapped solutes in the reservoir draws fluid from the patient across the semipermeable membrane and into the device. In some versions, the membrane can be changed as desired during the lifetime of the device by pulling the membrane out through the implanted device and putting a new one back in.

Abstract: A tube set for a blood handling apparatus, in particular an extracorporeal blood handling apparatus with an extracorporeal blood circuit or an apparatus for peritoneal dialysis, and a blood handling apparatus that has such a tube set are described. The tube set includes a device for collecting particles provided in a tube line portion of the tube set downstream of the tube portion placed in the occluding hose pump. The device for collecting particles prevents retention of solid substances that are possibly contained in the dialysis fluid, substituate or peritoneal solution. The tube set also has a device for limiting the pressure in the tube line portion between the occluding hose pump and the device for collecting particles. The device for limiting the positive pressure prevents an excessive positive pressure from building up in the tube line when fluid flow through the device for collecting particles is reduced or interrupted.

Abstract: The invention is directed to a method of removing a deleterious substance bound to a protein in blood of a patient by introducing a displacer substance into the blood under conditions in which the displacer substance replaces deleterious substance bound to the protein, thereby resulting in additional unbound deleterious substance in the blood, and removing unbound deleterious substance from the blood by extracorporeal renal replacement treatment.

Abstract: A novel system and method for fluid management for accurate continuous venovenous hemofiltration (CWH) in extracorporeal membrane oxygenation (ECMO). The fluid management or CWH system is automated and configured for operation as a stand alone unit and can be easily integrated with an ECMO system. The fluid management system is capable of producing either perfect or negative fluid balance between ultrafiltrate removal and replacement fluid delivery. The fluid management system can achieve electrolyte replacement over a range of flow rates needed to care for patients ranging from neonates to adults. Finally, the novel fluid management system preserves patient safety, maintains sterility during operation, is easy to operate, and is compact enough to fit near a patient's bed.

Abstract: A peritoneal dialysis system includes a dialysis machine including a pump chamber and a pump actuator moveable within the pump chamber; a pumping cassette including a rigid portion defining a pump well and a flexible membrane covering the pump well; and wherein the dialysis machine is configured to be mated with the pumping cassette so as to hold a vacuum between the pump chamber and the flexible membrane, the vacuum operable to cause the flexible membrane to follow the pump actuator as the actuator is retracted from the pump well of the rigid portion, the pump actuator operable to cause the flexible membrane to move into the pump well as the actuator is moved into the pump well.

Abstract: A peritoneal dialysis system includes a cycler operable with a disposable cassette, the cassette connected to a patient line, the cassette capable of fluid communication with a catheter having access to a patient's peritoneal cavity, the cycler configured to: (i) convey dialysis fluid to the peritoneal cavity through the patient line and the catheter during a patient fill phase; (ii) allow the dialysis fluid to dwell within the peritoneal cavity during a patient dwell phase; (iii) convey dialysis fluid away from the peritoneal cavity through the patient line and the catheter during a patient drain phase; and (iv) sense, at first and second sensing locations of the disposable cassette via first and second pressure sensors, an intraperitoneal pressure through the catheter to optimize an amount of fluid conveyed during the patient fill phase, so that the peritoneal cavity is not overpressurized during the patient dwell phase.

Abstract: A light applicator for a peritoneal dialysis conduit connection includes a housing having a inner surface; a plurality of ultraviolet (“UV”) light-emitting diodes (“LED's”) positioned on the inner surface of the housing; and circuitry connected to the UV-LED's such that power can be supplied to energize the UV-LED's simultaneously.

Abstract: The invention relates to a method for prescribing a dialysis treatment comprising the following steps: collecting patient specific data, determining at least one target, defining a series of values of the type [V;t] which allow to achieve said target wherein V represents the volume of dialysate used and t the duration of treatment, based on said patient specific data, displaying said series of values on a map. The invention also relates to a system using this method.

Abstract: A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation.

Abstract: A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.

Abstract: Systems and methods to reduce bioburden on at least a portion of a fluid transfer port include supplying a dose of radiation to the portion in optical communication with at least one source of radiation. In an illustrative example, a medical container, such as a vial or IV bag, receives a dose of ultraviolet (UV) energy substantially at a predetermined region of a fluid transfer site. In some examples, such a sanitization process may precede a fluid transfer operation in which a fluid is transferred into or out of the medical container by passing through the sanitized region. Such fluid transfers may be used in automated or semi-automated pharmaceutical processes, such as drug reconstitution. Various embodiments may further include one or more seal assemblies, each seal assembly having an aperture through which the radiation dose is supplied from the source to a controlled region on the fluid transfer port.

Abstract: A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence/absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

Abstract: A device for use in dialysis includes an elongated tubular body having a first end, a second end, and a lumen extending between the first end and the second end, and a first UV source coupled to the elongated tubular body at the second end, wherein the first UV source is configured to direct UV light for sterilizing at least a part of the elongated tubular body, wherein the second end of the elongated tubular body includes an opening in fluid communication with the lumen of the elongated tubular body, and a cover, the cover positionable at a first location to close the opening and at a second location to unblock the opening.

Abstract: A peritoneal dialysis system includes a removable cassette defining a flexible pump chamber and a pressure sensing area that is fluidly connected to the pump chamber wherein, during operation of the peritoneal dialysis system, peritoneal dialysis fluid is contained in the pump chamber; and a peritoneal dialysis machine configured to secure the removable cassette, peritoneal dialysis machine including (i) a pressure sensor positioned to align with and to contact the pressure sensing area of the removable cassette when the removable cassette is secured to the peritoneal dialysis machine, and (ii) a controller connected to the pressure sensor and adapted to change the operation of the peritoneal dialysis machine in response to changes in pressure sensed by the pressure sensor, wherein the pressure sensor and the pressure sensing area are arranged so that the pressure sensor measures a pressure of fluid in a fluid passage between the pump chamber and a patient during operation of the peritoneal dialysis system.

Abstract: A peritoneal dialysis system includes a logic implementer configured to: (i) generate a number of peritoneal dialysis therapy regimens that meet at least one therapy target input; (ii) accept a filter input; and (iii) filter the generated therapy regimens according to the filter input to refine the number of therapy regimens available for selection.