Abstract: The invention provides, in some aspects, a container system for medical solutions such as peritoneal dialysis (PD) solutions. The invention particularly features a system which includes a first compartment that contains a first medical solution, e.g., a PD osmotic agent, and a second compartment that contains a second medical solution, e.g., a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. To that end, a container system can include a diffuser that is disposed in a fluid pathway between the first and second compartments, e.g., to facilitate homogeneous mixing of the first and second PD agents.

Abstract: A medical fluid heating system operable with different supply voltages including first and second heater elements: first and second power lines, first, second and third switches in electrical communication with the first and second power lines, the switches configured such that (i) in a first switch state the first and second heater elements are placed in series, solely via a closing of the first switch, for operation with a first supply voltage applied to the first and second power lines, and (ii) in a second switch state the first and second heater elements are placed in parallel, via the second and third switches, for operation with a second supply voltage applied to the first and second power lines, and a control element configured to automatically set the switches in the first or the second switch state based upon a signal sent to the control element indicative of the first or the second supply voltage.

Abstract: A peritoneal dialysis patient assist device includes (i) a port holder shaped to hold a first connector and a first plug, (ii) a transfer set holder shaped to hold a second connector and a second plug, the transfer set holder rotatable and translatable with respect to the port holder, and (iii) an ultraviolet (“UV”) applicator positioned to radiate UV light on at least part of the first and second connectors when loaded into the port and transfer set holders, respectively.

Abstract: A dialysis system includes at least one pump actuator, a disposable cassette operable with the at least one pump actuator, a plurality of disposable cassette supply connections, and plurality of dialysis solution lines. Each of the plurality of solution lines is connected to a dialysis solution container. The system further includes an autoconnection mechanism configured to connect the plurality of supply connections to the plurality of dialysis solution lines. The system additionally includes an autoidentification system configured to automatically identify information associated with the plurality of dialysis solution lines to determine at least one of (i) dialysis solution type (ii) dialysis solution volume, or (iii) a number of the plurality of dialysis solution supply containers.

Abstract: A stand for a medical fluid treatment, a system for supporting medical fluid bags, and a method for testing and sensing whether a bag or a seal in a chamber of a multi-chamber bag has been broken prior to providing therapy. A stand stores one or more medical fluid bags, each bag stored on a single shelf. Each shelf has a sensor for sensing the presence or absence of fluid in the bag, and reporting the status of the bag to a central location, such as a computer. The sensor can also detect and report on whether fluid has leaked from the bag, or in the case of bags with two or more chambers, if a leak in a frangible seal separating the chambers has developed.

Abstract: Provided is a method for treating or preventing peritonitis by administering a therapeutically effective amount of an oxidative reduction potential (ORP) water solution that is stable for at least about twenty-four hours. The ORP water solution administered in accordance with the invention can be combined with one or more suitable carriers and can be administered in conjunction with one or more additional therapeutic agents. Further provided is a method for preventing peritoneal hemorrhage, adhesions and abscesses.

Abstract: An indicator assembly for use with a non-vascular catheter device The indicator assembly includes: a first retainer secured to a catheter tube, the first retainer being an indwelling retainer which is deployed within a non-vascular lumen or cavity of the body; a second retainer secured to the catheter tube, the second retainer deployed outside the human body; and an indicator located outside the body on the catheter tube between the first retainer and the second retainer. The first retainer and the second retainer are configured to maintain substantially the same position with respect to each other on the tube and the indicator is configured to signal a change in position with respect to either the first or the second retainer, thereby indicating a change in the length of a stoma.

Abstract: The present invention relates to a device (20) for collecting dialysate samples (42). The device (20) comprises an inlet (22) for receiving a flow of dialysate, a plurality of outlets (24) for providing a flow of saturated dialysate and means (26) for sequential selection of one of the outlets (24). The sequential selection means (26) are activated only by the flow of dialysate received from the inlet (22). The present invention further relates to a system for peritoneal dialysis comprising such device (20).

Abstract: A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.

Abstract: In some aspects, a method includes determining whether a universal serial bus (USB) peripheral device is connected to a USB monitoring device that is connected to a medical device and drawing power from the medical device. The medical device is configured for use in a medical procedure with a patient. The method also includes determining whether the USB peripheral device is drawing power from the medical device if the USB peripheral device is determined to be connected to the USB monitoring device.

Abstract: A microdialysis probe including a probe body, a supply line and a discharge line for a perfusion solution and a dialysis membrane, wherein a probe needle for introduction into a tissue is provided by a generally elongate frame. The frame has at least one recess at least partially open for receiving at least a portion of the supply and discharge lines. The invention encompasses a method for making such a probe, wherein the method includes arranging a dialysis membrane on a shaping device, shaping the dialysis membrane in a selected shape, applying an adhesive agent to the dialysis membrane to keep the membrane in the selected shape, and separating the dialysis membrane and the shaping devices after the adhesive agent has been applied.

Abstract: The present system and method in one embodiment limit a maximum instantaneous peritoneal volume to a comfortable level, while allowing the dialysis machine to advance to fill a prescribed volume whenever the drain ends after a minimum drain percentage has been attained. If a low drain condition occurs, the nominal fill volume is lowered and a therapy cycle is added, so that a prescribed total amount of fresh therapy fluid is used during therapy, maximizing therapeutic benefit. An allowable residual volume at the end of an incomplete drain is increased, thereby lowering the probability of a subsequent low drain condition.

Abstract: A peritoneal dialysis system includes: a hardware unit including a piston having a contact surface, a pneumatic source for supplying a negative pressure, a stepper motor, a controller including a processor and memory programmed to control the pneumatic source and the stepper motor, and a video monitor operating with a touch screen for sending and receiving information to and from the controller; and a disposable unit including a moveable membrane positioned adjacent to the contact surface, the programmed processor and memory operable to (i) cause the pneumatic source to apply the negative pressure to the membrane so that the negative pressure moves the membrane to conform to a shape of the contact surface and (ii) control the stepper motor so that the membrane follows the piston as the piston is moved away from the disposable unit and moves with the piston as the piston is moved into the disposable unit.

Abstract: In an embodiment, a dialysis fluid cassette is disclosed. The cassette includes a plurality of walls defining at least one valve chamber, a dialysis fluid inlet, a dialysis fluid outlet and a dialysis fluid pathway. The cassette further includes a baffle extending from a first one of the walls to an opposing second one of the walls. The baffle includes an end fixed to a third one of the plurality of walls and a free end. The fixed end separates the dialysis fluid inlet from the dialysis fluid outlet and the baffle and the plurality of walls are constructed and arranged such that the flow of dialysis fluid along the pathway defined in part by the baffle slows as the flow approaches the free end of the baffle.

Abstract: This patent application relates generally to identifying a self-powered device connected to a medical device.

Abstract: The present invention is a peritoneal dialysis and hemodialysis hybrid-remedy planning method using an index that is shared by both peritoneal dialysis and hemodialysis and indicates an effect of dialysis. To be specific, the index is M/C(0)/VB, which is obtained by dividing a ratio M/C(0)—where M is a removal amount of a solute for a fixed time period, and C(0) is a concentration of the solute in blood before the dialysis—by a patient's body fluid volume, VB. The present invention is capable of representing the dialysis effect of PD and HD as an integrated sum, and achieving concise and explicit PD and HD hybrid-remedy planning.

Abstract: A peritoneal dialysis machine including a membrane pump and a touch screen display that includes a mode-indicating portion and an operation-descriptive portion, the mode-indicating portion having a plurality of touch sensitive indicia each indicating one of a plurality of modes in which the machine can operate, the display being used to keep a patient continually informed of which one mode of at least three operating modes the machine is operating in, as the operation-descriptive portion changes to display details of a specific operation being carried out within the one mode, the indicia for each of the three operating modes always being visible to the patient while the machine is operating, the operating mode being selected by the patient touching one of the indicia on the screen.

Abstract: A peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine including a logic implementer and a wireless interface receiver. The system also includes at least one of a scale or a blood pressure monitor including a wireless interface transmitter. The scale or blood pressure monitor is operable to send at least one of patient blood pressure data and patient weight data wirelessly, respectively, to the wireless interface receiver. The logic implementer is configured to store the patient blood pressure data or patient weight data. A server computer is configured to communicate with the logic implementer to receive the stored at least one patient blood pressure data and patient weight data.

Abstract: A cassette is described for holding circuit components used with a hemodialysis machine.

Abstract: A dialysis system includes a dialysis instrument and a disposable cassette. The dialysis instrument includes three pump actuators. The disposable cassette includes three dialysate pump chambers. The three dialysate pump chambers are positioned and arranged to operate with the three dialysate pump actuators of the dialysis instrument.

Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.

Abstract: A valve integrity method for a medical fluid pump includes pumping fluid into the medical fluid pump while an outlet valve is closed and an inlet valve is open, closing the inlet valve while the outlet valve is closed, attempting to pump fluid out of the medical fluid pump while the inlet valve and the outlet valve are closed, and determining that at least one of the valves is leaking if a change in medical fluid volume within the medical fluid pump is detected.

Abstract: A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation.

Abstract: The present invention is a peritoneal dialysis and hemodialysis hybrid-remedy planning method using an index that is shared by both peritoneal dialysis and hemodialysis and indicates an effect of dialysis. To be specific, the index is M/C(0)/VB, which is obtained by dividing a ratio M/C(0)—where M is a removal amount of a solute for a fixed time period, and C(0) is a concentration of the solute in blood before the dialysis—by a patient's body fluid volume, VB. The present invention is capable of representing the dialysis effect of PD and HD as an integrated sum, achieving concise and explicit PD and HD hybrid-remedy planning.

Abstract: A method for connecting a plurality of solution line connectors to a plurality of supply line connectors of a dialysis system includes: translating a tip protector remover in a first direction towards the plurality of supply line connectors to remove a plurality of solution line tip protectors from the plurality of solution line connectors; locking the tip protector remover to each of a plurality of supply line tip protectors connected to the plurality of supply line connectors; translating the tip protector remover in a second direction towards the plurality of solution line connectors to remove the plurality of supply line tip protectors from the supply line connectors; translating the tip protector remover in a third direction different from the first and second directions; translating one of the plurality of solution line connectors and the plurality of supply line connectors the other of the solution line connectors and the supply line connectors to connect each of the solution line connectors to one of

Abstract: Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.

Abstract: A hydration management system includes a console for mounting on an IV pole. A urine collection bag and a hydration fluid bag hang from the console. Urine in the urine collection bag is weighed. An infusion pump is configured to pump hydration fluid from the infusion bag. A controller is responsive to the weight of the urine collection bag and controls the infusion pump to hydrate the patient based on the patient's urine output. An infusion set includes an infusion bag connector, an IV needle connector, and tubing, placed in the infusion pump, extending between the infusion bag connector and the IV needle connector. A urine collection set typically includes the urine collection bag, a catheter connector, and tubing extending between the urine collection bag connector and the catheter connector.

Abstract: A dialysis fluid heating system includes a dialysis fluid heater; a dialysis fluid carrying element in operable communication with the dialysis fluid heater to heat a dialysis fluid; and a logic implementer configured to control the heater using (i) a heater input determined from a dialysis fluid temperature delta and a dialysis fluid flowrate, and (ii) a potential adjustment of the temperature delta using a measured dialysis fluid outlet temperature.

Abstract: A peritoneal dialysis system includes a hardware unit including a piston and at least one vacuum source; a door connected to the hardware unit, the door including a cavity, the cavity having a diameter; the hardware unit further including a structure positioned opposite the door, the structure defining an aperture; a disposable unit including first and second fluid receiving membranes, the disposable unit disposed between the structure and the door; the at least one vacuum source operable to apply a vacuum to at least one of the first and second membranes of the disposable unit; the piston, at least a portion of which moves through the aperture, in operation contacting one of the membranes, the piston including a piston head having a diameter smaller than the diameter of the cavity in the door; and a dialysis fluid opening enabling dialysis fluid to be pulled in between the first and second membranes.

Abstract: A peritoneal dialysis machine including: a housing; a mechanically actuated piston head extending from a pump actuator housed by the housing, the mechanically actuated piston head positioned to extend towards and away from a fluid pumping cassette, the fluid pumping cassette coupled operably to the housing such that a flexible membrane of the fluid pumping cassette faces the piston head; a pressure sensor positioned by the housing adjacent to the mechanically actuated piston head so as to sense a pressure of a medical fluid moved by the mechanically actuated piston head within the fluid pumping cassette; and a vacuum chamber formed about the mechanically actuated piston head, the vacuum chamber holding a vacuum that sucks the flexible membrane of the fluid pumping cassette onto the mechanically actuated piston head as the mechanically actuated piston head extends away from the fluid pumping cassette.

Abstract: A split-tip catheter for placement within the vasculature of a patient and for use in hemodialysis or other suitable procedures is disclosed. In one embodiment, the split-tip catheter includes a catheter body that defines a first lumen and a second lumen. The catheter body further comprises a split distal region, including a venous segment that defines a distal portion of the first lumen and an arterial segment that defines a distal portion of the second lumen. The venous segment includes a recess extending proximally of a nose portion; and a lateral opening in fluid communication with the first lumen. The arterial segment is separate from the venous segment and is removably seatable in the recess provided by the venous segment such that it “nests” therein. The arterial segment also includes a lateral opening in fluid communication with the second lumen.

Abstract: A peritoneal dialysis system includes a hardware unit including a piston having a contact surface and a stepper motor configured to move the piston; and a disposable unit received by the hardware unit, the disposable unit including a moveable membrane operable with the contact surface of the piston, the piston moveable towards and away from the disposable unit, wherein (i) the piston and the membrane are positioned relative to each other and (ii) the hardware unit is configured to apply a negative pressure to the moveable membrane of the disposable unit so that the negative pressure causes the moveable membrane to contact and conform to a shape of the contact surface and to follow the piston as the piston is moved away from the disposable unit by the stepper motor, and wherein the shape-contacted membrane moves with the piston as the piston is moved into the disposable unit by the stepper motor.

Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Abstract: In one embodiment an automated peritoneal dialysis (“APD”) machine includes: at least one pump; a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient; and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the is APD machine.

Abstract: A dialysis system includes a dialysis instrument; a disposable cassette, the cassette including a rigid portion defining at least one pumping chamber, a pouch fitted over the rigid portion, the pouch including at least one flexible sheet sealed so as to provide a sealed environment inside the pouch; and wherein the instrument is configured to press the at least one flexible sheet against the pumping chamber to seal the pumping chamber for operation.

Abstract: A peritoneal dialysis system includes: an automated peritoneal dialysis (“APD”) machine configured to remove ultrafiltrate (“UF”) from a patient and record how much UF has been removed; and a logic implementer configured to (i) form a first moving average UF removed trend, (ii) determine a trending range around the first moving average UF removed trend, (iii) determine at least one of an upper and lower UF removed limit from the trending range, (iv) form a second moving average UF removed trend, and (v) alert if the second moving average UF removed trend moves outside of the at least one UF removed limit.

Abstract: A peritoneal dialysis machine includes an enclosure; dialysate pump located within the enclosure; a graphical user interface allowing a patient to program a treatment including at least one patient fill performed by the dialysate pump, at least one dwell, and at least one drain performed by the dialysate pump; and the GUI further programmed to provide an alert when it is time to begin the treatment so as to complete the at least one patient fill, dwell and drain by a prescribed time.

Abstract: The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.

Abstract: The invention relates to a device for loading a patient connector for peritoneal dialysis with a closure plug. To permit an arbitrary number of disconnection/connection procedures with patient connectors that insert a sterile closure plug into the patient's abdominal connector during disconnection, a device for loading a patient connector for peritoneal dialysis with a closure plug is suggested, said device consisting of a housing containing a closure plug and of means for transferring the closure plug out of the device and into a patient connector. This permits loading, under sterile conditions, of a patient connector whose closure plug has already been used with a new closure plug. By loading a new closure plug, the push-button with which the closure plug is inserted is returned to its starting position, so that the patient connector is again available for a connection/disconnection procedure.

Abstract: A system, process, and method for home hemodialysis or peritoneal dialysis to be carried out by the patient or other non-professional users based upon re-circulation of dialysate from small dialysate containers which allows for very small dialysate consumption and easy portability. The system thereby also allow for long-duration dialysis without use of large volumes of dialysate. The invention may be implemented as a hemodialysis system, a process for administering dialysate, or as a method for performing dialysis.

Abstract: A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.

Abstract: A dialysis machine having a multiple line voltage heater includes first and second heater elements, first and second switching devices connected electrically to the first and second heating elements, first and second power lines, and a control element configured to provide a first switching device state in which power at a first voltage is supplied via the first and second power lines to both first and second heater elements via both first and second switching devices and a second switching device state in which power at a second voltage is supplied via the first and second power lines to the first heater element only via the first switching device.

Abstract: A medical fluid machine with supply autoconnection, the machine comprising: a cassette-receiving wall; a disposable cassette held firmly by the wall, the disposable cassette including a port spike, the port spike fitted with a spike cap; a translating shuttle including a channel sized to hold a portion of a supply tube and including a fixture for releasably holding a supply tube end; a supply tube including an end configured to be releasably held by the fixture of the channel of the translating shuttle, the supply tube fitted with a supply tube cap; a cap removal device selectively positionable between the disposable cassette and the translating shuttle; and a controller programmed to (i) translate the shuttle holding the supply tube at the supply tube end towards the disposable cassette, so that the cap removal device is likewise moved towards the disposable cassette and the spike cap of the disposable cassette is engaged, (ii) translate the shuttle holding the supply tube at the supply tube end away from th

Abstract: A split tip dialysis catheter having an outer tube and an inner tube, the two tubes which can be arranged over at least a portion of their length in a coaxial configuration. The inner tube may be connected to the outer tube at a proximal bifurcation, secured at a distal end of the outer tube or both, but generally the inner tube will remain free to move relative to the outer tube to optimize functionality. In addition, the inner tube can be arranged to be removable from the catheter for replacement thereof.

Abstract: Temperature compensation is applied to correct for temperature mismatch between a reference chamber and a disposable chamber in a pneumatic pumping system for dialysis fluid for peritoneal dialysis. The mismatch creates an error in the calculation of pumping volume of dialysate fluid. Applying a correction for the temperature mismatch helps to more precisely control the volume of dialysate that is metered to the patient. Also disclosed are ways to keep temperatures constant and to use temperature sensors to accurately measure the temperatures of the chambers. In other aspects, the temperature of the dialysate fluid itself may be measured and used to apply a correction to the volume of fluid that is pumped to the patient.

Abstract: A fluid pumping mechanism in one embodiment includes a fluid reservoir, and a multiple layer film extending over a portion of the fluid reservoir, wherein fluid is moved through the reservoir by movement of the film from a first position to a second position, the film including first and second layers, each of first and second layers comprising a blend of a polypropylene and a styrene ethylene butadiene block copolymer. Peritoneal dialysis systems are also provided and may include a peritoneal dialysis machine and a disposable cassette defining at least one pump chamber and having a multiple layer film extending over a portion of the at least one pump chamber, the film including first and second layers, each of the first and second layers comprising a blend of a polypropylene and a styrene ethylene butadiene block copolymer.

Abstract: The present disclosure relates to a wearable dialysis system and method for removing uremic waste metabolites and fluid from a patient suffering from renal disease. Uremic waste metabolites can be removed by a wearable peritoneal dialysis device that regenerates the peritoneal dialysis solution without removing positively charged, essential ions from the solution and, consequently, the patient. Fluids can be removed from the blood of the patient by an implantable fluid removing device. Fluids are delivered to the bladder and preferably removed from the body of the patient through urination. The wearable dialysis system may be operated continuously or semi-continuously and be comfortably adapted to the body of the patient while allowing the patient to perform normal activities.

Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Abstract: A medical fluid machine includes an enclosure; a disposable unit accepted by the enclosure, the disposable unit including a conduit through which a medical fluid can flow, the conduit including a viewing portion; a light source configured and arranged to emit light onto the viewing portion of the conduit; a camera focused on the viewing portion of the conduit; and a processor configured to determine a speed of a particle entrained in the medical fluid based on at least two images of the particle in the viewing area taken by the camera.

Abstract: A peritoneal dialysis (PD) system that includes a disposable PD cassette including a base having a substantially planar portion and a dome-shaped protrusion extending from the substantially planar portion and a flexible membrane attached to the base and covering a recessed region of the dome-shaped protrusion to form a pumping chamber between the flexible membrane and the recessed region of the dome-shaped protrusion. The system also includes a PD machine including a deck and a door hinged from one side to the deck. The door and the deck can cooperate to form a cassette compartment, and the door has a cylindrical recess positioned to receive the dome-shaped protrusion of the base of the disposable PD cassette when the disposable PD cassette is disposed in the cassette compartment and the door is closed.