Adhesively Attachable To Body Patents (Class 604/307)
  • Patent number: 10428458
    Abstract: The present invention relates to a medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers as prepared by the paper making process, a preparation method thereof, and an adhesion prevention barrier using the same. The present invention provides a single phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, to induce capillary action of micropores formed between the fibers and thereby control the gelation time, and provides a composite nonwoven fabric formed by laminating a nonwoven fabric layer comprising a different kind of biodegradable polymer material not susceptible to gelation on the single-phase of medical nonwoven fabric comprising gelable cellulose derivative short-cut fibers, thereby improving dimensional stability and convenience of surgical procedure. The present invention further provides a dyed medical nonwoven fabric to improve visibility, allowing easiness of recognizing the placement or location of the medical nonwoven fabric.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: October 1, 2019
    Assignee: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY
    Inventors: Jung Nam Im, Dae Young Lim, Guk-Hwan An, Yoon Jin Kim
  • Patent number: 10406116
    Abstract: Described are pressure-sensitive adhesive polymers (PSAs) useful, for example, for application to the skin, such as in the field of transdermal drug delivery. The PSAs include polar groups modeled on one or more polar portions of skin lipids, which contribute to good skin adhesion properties. Methods of making the PSAs, compositions comprising them, and methods of making and using them also are provided.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 10, 2019
    Assignee: NOVEN PHARMACEUTICALS, INC.
    Inventors: Jilin Zhang, Jun Liao, Puchun Liu, Steven Dinh
  • Patent number: 10377114
    Abstract: Methods of producing a transdermal delivery patches are described comprising the preparation of a uniform suspension of drug particles. A plasticizer is added to the suspension. A solution of an adhesive is add to the suspension to form a drug suspension in the adhesive mixture. The drug suspension is coated on a release liner and all solvents are evaporated to form a solid drug reservoir layer. A medical device for transdermal administration of a drug can include the solid drug reservoir layer. Suitable drugs include fentanyl and sufentanil.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 13, 2019
    Inventors: Spiros Fotinos, Jerome Langlume, Jean Paul Caravita
  • Patent number: 10350174
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 16, 2019
    Assignees: UCB Pharma GmbH, LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • Patent number: 10130589
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: November 20, 2018
    Assignees: UCB Pharma GmbH, LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • Patent number: 10010511
    Abstract: A transdermal drug delivery system is provided that includes a drug-in-adhesive matrix layer and a backing layer. The matrix layer includes an active pharmaceutical ingredient, a cross-linked polyvinylpyrrolidone binder, a mesoporous silicon dioxide filler, and a pressure sensitive adhesive, while the backing layer forms an exterior facing-surface of the delivery system. The ratio of the mesoporous silicon dioxide filler to the cross-linked polyvinylpyrrolidone binder ranges from about 1:1 to about 1:8. As a result of the specific components of the matrix layer and the amounts in which they are utilized, the resulting delivery system, which can include a homogeneous dispersion of the active pharmaceutical ingredient in the formulation, is capable of delivering the active pharmaceutical ingredient over a period of up to about 7 days in a generally constant and controlled fashion. Further, the only layer that contemplates the use of an adhesive component is the drug-in-adhesive matrix layer.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: July 3, 2018
    Assignee: ProSolus, Inc.
    Inventors: Rod L. Hartwig, David Houze
  • Patent number: 9962533
    Abstract: A module producible inside a living body is provided. The module includes an instructions receiver configured to receive wireless transmissions of instructions from a master controller located outside of the body when the module is inside the body. An energy receiver configured to receive wireless transmission of non-destructive energy from the master controller located outside of the body when the module is inside the body. The module further includes a battery and a communications and guide element electrically connected to the instructions receiver, the energy receiver and the battery.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: May 8, 2018
    Inventor: William Harrison Zurn
  • Patent number: 9907710
    Abstract: A disposable diaper includes: a first inflected unit formed in an absorber and extending along a product widthwise direction; a second inflected unit formed in the absorber, extending along the product widthwise direction, and positioned towards a rear waistline unit from the first inflected unit; and a crotch unit formed between the first inflected unit and the second inflected unit. The size of the crotch unit along the product longitudinal direction is 30 mm or more and 150 mm or less in the natural state of the disposable diaper.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: March 6, 2018
    Assignee: UNICHARM CORPORATION
    Inventor: Satoru Sakaguchi
  • Patent number: 9872934
    Abstract: The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: January 23, 2018
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Hans Christian Hedrich, Joris Hoefinghoff, Woonza M. Rhee, Atsushi Edward Osawa
  • Patent number: 9775815
    Abstract: The invention discloses a gastric resistant pharmaceutical or nutraceutical composition, comprising a core, comprising a pharmaceutical or nutraceutical active ingredient and a gastric resistant coating layer onto the core, wherein the gastric resistant coating layer comprises at least 30% by weight of a (meth)acrylate copolymer comprising polymerized units of 10 to 40% by weight of acrylic or methacrylic acid, 10 to 80% by weight of a C4- to C18-alkyl ester of acrylic or methacrylic acid and optionally 0 to 60% by weight of another vinylic monomer, whereby the release of the pharmaceutical or nutraceutical active ingredient is not more than 10% under in-vitro conditions at pH 1.2 after 2 hours in medium according to USP with and without the addition of 20% (v/v) ethanol.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: October 3, 2017
    Assignee: Evonik Roehm GmbH
    Inventors: Jan Hendrik Schattka, Christian Meier, Herbert Jung, Hedi Krachtus, Jessica Del Rosario Ferrand
  • Patent number: 9757428
    Abstract: According to aspects illustrated herein, there is provided an agent that transiently disrupts claudin-1 within tight junctions. The agent includes a peptide having at least 40% polar, uncharged amino acid residues and a self-assembled ?-sheet secondary structure. According to aspects illustrated herein, there is also provided a transepithelial drug and vaccine formulations, as well as isolated peptides, pharmaceutical compositions, and transdermal delivery devices. Also described herein are methods of disrupting epithelial barrier and methods of administering the transepithelial formulations described herein.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: September 12, 2017
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Anna De Benedetto, Lisa A. Beck, Elizabeth A. Anderson
  • Patent number: 9730900
    Abstract: Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and using such systems also are described.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: August 15, 2017
    Assignee: Noven Pharmaceuticals, Inc.
    Inventor: Juan Mantelle
  • Patent number: 9724310
    Abstract: Described are transdermal drug delivery systems for the transdermal administration of estrogen, comprising a polymer matrix and estrogen. Methods of making and using such systems also are described.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: August 8, 2017
    Assignee: Noven Pharmaceuticals, Inc.
    Inventor: Juan Mantelle
  • Patent number: 9675698
    Abstract: The present invention relates to a pharmaceutical composition in the form of a hydro-alcoholic gel or a solution for transdermal application, comprising: from about 0.2% to about 1.5% of dihydrotestosterone; and from about 0.2 to about 3% of isopropyl myristate.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 13, 2017
    Assignee: BESINS HEALTHCARE LUXEMBOURG SARL
    Inventors: Valerie Masini-Eteve, Brigitte Taravella
  • Patent number: 9629585
    Abstract: Wearable patches comprising multiple separable adhesive layers. One or more of the layers can comprise electronics, mechanical components, gauze, medicine and/or other types of hardware suitable for the intended use of the patch. In use, a first layer of the patch is adhered to a user. When it is time to change layers, the patch is removed from the user, the first layer is removed from the patch to expose a second adhesive layer, and the second layer is applied to the user. The process may be repeated until the remaining layers of the patch have been used.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: April 25, 2017
    Assignee: ZANSORS LLC
    Inventors: Ranjit Das, Mark Travaglini
  • Patent number: 9625065
    Abstract: The invention relates to a molded body, especially for parts, top shells, inner elements, accessories and components of devices, for molding materials, filling materials for medical technical devices and/or medical products. The inventive molded body is characterized by being in at least some sections germ-repellant. The invention also relates to a medical device which comprises at least one molded body according to the invention. The invention finally relates to a method for producing the inventive molded body.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: April 18, 2017
    Assignee: Loewenstein Medical Technology S.A.
    Inventors: Karl-Andreas Feldhahn, Gerd Schulz, Martin Eifler, Arnold Frerichs, Thomas Marx, Elmar Vitt
  • Patent number: 9480760
    Abstract: Light-activated antimicrobial devices and articles are disclosed. The devices include a light source and a light-activated antimicrobial article comprising a photosensitizer and a viscoelastic material such as a pressure sensitive adhesive adapted to receive light from the light source. The viscoelastic material may be adapted to transport light by total internal reflection. The photosensitizer may comprise a dye, a metal oxide or a composition that comprises anions that oxidize or react to form a gas. Upon activation of the light source, the photosensitizer absorbs light from the light source such that antimicrobial activity is exhibited. The photosensitizer may be included in the light-activated antimicrobial article or it may be provided as a topical composition that is separate from the article. The light-activated antimicrobial articles and devices may have constructions similar to those of wound dressings.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: November 1, 2016
    Assignee: 3M Innovative Properties Company
    Inventors: Maria A. Appeaning, Audrey A. Sherman, Michael A. Meis, Marie A. Boulos, Kevin D. Landgrebe, Kevin R. Schaffer, Matthew T. Scholz, Thu-Van T. Tran, Narina Y. Stepanova, Caroline M. Ylitalo
  • Patent number: 9439997
    Abstract: The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: September 13, 2016
    Assignees: Ethicon, Inc., Omrix Biopharmaceutical, Inc.
    Inventors: Anne Jessica Gorman, Sanyog Manohar Pendharkar, Guanghui Zhang, Liliana Bar, Israel Nur, Roberto Meidler
  • Patent number: 9433533
    Abstract: The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: September 6, 2016
    Assignee: NITTO DENKO CORPORATION
    Inventors: Katsuhiro Okada, Yoshihiro Iwao, Kensuke Matsuoka
  • Patent number: 9345670
    Abstract: The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability, and has a preferred handleability. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 ?m to 16 ?m; and the pressure-sensitive adhesive layer is laminated on the polyester base layer.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: May 24, 2016
    Assignee: NITTO DENKO CORPORATION
    Inventors: Tomohito Takita, Masahiro Mitsushima, Hidetoshi Kuroda, Yuji Saeki
  • Patent number: 9192521
    Abstract: An adhesive dressing that reduces the leakage of wound exudate from the dressing, comprising an adhesive-coated backing sheet; and an absorbent island adhered to said adhesive-coated backing sheet by said adhesive, having a first end and a second end, wherein the absorption capacity of the absorbent island is higher at the first end than at the second end. The adhesive dressing of the invention provides extended wear time for the dressing when it is applied to wounds.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: November 24, 2015
    Assignee: KCI USA, Inc.
    Inventor: Stuart Boothman
  • Patent number: 9186283
    Abstract: A wound dressing is provided which includes an inner layer with a plurality of drain holes around the perimeter. The inner layer is resistant to penetration by liquid. Adjacent the inner layer is an absorbent layer. An outer layer is adjacent, but not attached to the absorbent layer. The outer layer is resistant to penetration by liquid. The outer layer includes an adhesive band. A removable protective layer covers the adhesive bands and includes a plurality of perforations spaced about the protective layer with a plurality of non-perforated sections between the perforations such that when removed, the perforations cause separation at the perforations and only one non-perforated section is removed at a time. A base layer is provided with an open area and adhesive bands. The base layer is attached to the skin and the outer layer covers the open area of the base layer.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: November 17, 2015
    Inventor: Matthew G. Ferris
  • Patent number: 9125766
    Abstract: An apparatus and system for treating a wound having a cavity is disclosed. The apparatus comprises a scaffold including a scaffold lamina and a tissue lamina wherein the scaffold lamina forms a laminate in fluid communication with the tissue lamina. The laminate is rolled into a generally cylindrical shape having two end surfaces. The apparatus further comprises a manifold having a port for coupling to a source of reduced pressure and that is positioned in fluid communication with the scaffold to provide reduced pressure to the scaffold lamina and the wound. The apparatus also comprises a drape formed of substantially impermeable material to cover the scaffold and the manifold within the wound.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: September 8, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D. Swain, Michael E Manwaring, Douglas A. Cornet, Braden K Leung
  • Patent number: 9107995
    Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: August 18, 2015
    Assignee: MiniPumps, LLC
    Inventors: Changlin Pang, Fukang Jiang, Jason Shih, Sean Caffey, Mark S. Humayun, Yu-Chong Tai
  • Patent number: 9066789
    Abstract: Apparatuses to be worn by users proximate their ankles to manage pressure and swelling, the apparatus including a wrap shaped to conform to a portion of a foot and a lower leg of the user. In some examples, the wrap defines a compressible multiple layer construction including at least one layer that including a compressible foam, a channel sized to receive a portion of the foot and the lower leg, a substantially stretchable flap sized to extend across the channel when the foot and the lower leg are positioned within the channel, a leg portion, and a foot portion, wherein the leg portion may be flexibly angled from the foot portion a bandaged area including the user's ankles. In some examples, the wrap is configured to be fitted around a portion of the user's foot and lower leg to compress at the ankle area to a selected barrier pressure.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: June 30, 2015
    Inventor: Michael Dennis
  • Publication number: 20150148759
    Abstract: The invention relates to a pharmaceutical patch for transdermal administration of the pharmacologically active ingredient Tapentadol or a physiologically acceptable salt thereof, the patch comprising a surface layer, an adhesive layer which comprises a pressure sensitive adhesive and at least a portion of the total amount of the pharmacologically active ingredient that is contained in the pharmaceutical patch, and a removable protective layer, wherein the adhesive layer is located between the surface layer and the removable protective layer.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 28, 2015
    Inventors: Ingo FRIEDRICH, Martin MIKYNA, Sandra GEDAT
  • Publication number: 20150148758
    Abstract: The purpose is to provide a mirtazapine-containing transdermal patch capable of suppressing deposition of a crystalline component derived from mirtazapine, deterioration in sense of use, and deterioration in adhesiveness to the skin. The transdermal patch contains a support, a drug-containing layer and a release liner, and the drug-containing layer contains mirtazapine and an organic acid.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 28, 2015
    Applicant: Yutoku Pharmaceutical Industries Co., Ltd.,
    Inventors: Makoto Yoshitake, Kenta Nishimura
  • Publication number: 20150119828
    Abstract: Compositions for the transdermal delivery of amphetamine in a flexible, finite form are described. The compositions comprise a polymer matrix that includes amphetamine or a pharmaceutically acceptable salt or prodrug thereof and a backing layer comprising a polyurethane film layer and a polyester film layer, with a polyurethane adhesive disposed therebetween. Related methods also are described.
    Type: Application
    Filed: December 30, 2014
    Publication date: April 30, 2015
    Applicant: NOVEN PHARMACEUTICALS, INC.
    Inventor: Robert L. Lambert
  • Patent number: 9017301
    Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured highly crosslinked silicone. The present invention also refers to a method of preparing a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured silicone.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: April 28, 2015
    Assignee: Mylan Technologies, Inc.
    Inventor: Jiansheng Tang
  • Patent number: 9017302
    Abstract: A composite wound dressing and delivery apparatus includes a substantially transparent dressing layer having a lower surface that is coated with a pressure sensitive for applying the dressing layer over a wound to define a reservoir in which a negative pressure may be maintained. A substantially transparent backing layer adhered to the lower surface of the dressing layer in a releasable manner, and a vacuum port is centrally located on the dressing layer. The vacuum port is adapted to provide fluid communication between a vacuum source and the reservoir through the dressing layer. A targeting grid associated with either the dressing layer or the backing layer includes regularly spaced reference marks along at least two axes extending from the vacuum port.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 28, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Ronald F. Vitaris, Rose Anderson, Deirdre McKeown, Adam M. Ruggles
  • Publication number: 20150104495
    Abstract: Described are transdermal drug delivery compositions comprising amphetamine, methods of manufacturing transdermal drug delivery compositions comprising amphetamine, and therapeutic methods using transdermal drug delivery compositions comprising amphetamine, such as may be desired for achieving central nervous system stimulation, such as for the treatment of attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), or for the treatment of narcolepsy. In some embodiments, the compositions comprise an amount of polyurethane effective to control the presence of and/or prevent the formation of phenyl acetone in the compositions. The polyurethane may be present in a drug-containing polymer matrix or in a backing adjacent the drug-containing polymer matrix.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: Noven Pharmaceuticals, Inc.
    Inventors: Viet Nguyen, Steven DINH, Jun LlAO, Robert L. LAMBERT
  • Patent number: 9005174
    Abstract: The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: April 14, 2015
    Assignee: Nitto Denko Corporation
    Inventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi
  • Patent number: 8992491
    Abstract: The present invention relates to a bandage including an adhesive hydrocolloid mass, wherein said bandage includes, on at least one portion of the surface of the adhesive mass intended for being in contract with the wound when the bandage is being used, a plurality of agglomerates made up of particles linked to one another, preferably in a multi-layer configuration, at least 90% and preferably at least 95% of said particles being made up of one (or more) material(s) selected among polysaccharides, proteins and synthetic polymers, and being suitable for solubilizing or gelling in under ten seconds, and preferably still in less than one second when in contact with the exudate from the wound. The bandage according to the invention is intended for treating wounds such as blisters, exuding wounds, burns and dermal-epidermal lesions, whether superficial, deep, chronic or acute.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: March 31, 2015
    Assignee: Laboratoires Urgo
    Inventor: Jean-Marc Pernot
  • Patent number: 8993829
    Abstract: A bandage and method for securing a tension member comprising a central body and a plurality of tabs disposed about the central body. A tension member may be disposed across or through a slit or aperture of the central body. A body adhesive on the lower surface of the central body may secure the bandage to the patient. The tension member may then be pulled across the upper surface of the central body and a first tab may be folded over and adhered to the tension member and central body. The tension member may then be pulled back across the first tab and a second tab may be folded over and adhered to the tension member and first tab. Likewise, the tension member may then be pulled back across the second tab and a third tab may be folded over and adhered to the tension member and second tab.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: March 31, 2015
    Inventor: Ralph Zipper
  • Publication number: 20150051559
    Abstract: Disclosed is a transdermal patch for treatment of degenerative neurological disorders like dementia or Alzheimer type dementia. More particularly, the transdermal patch for treatment of neurodegenerative disorder comprises an adhesive monolayer which comprises Rivastigmine in free base form or its pharmaceutically acceptable salts, styrene block copolymer, and a tackifier, wherein total styrene units are in an amount of 4% w/w or more of said adhesive monolayer.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 19, 2015
    Inventor: Noriyuki Kuzumaki
  • Publication number: 20150045749
    Abstract: Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then formulating along with an adhesive; and a process for preparing the same. The transdermal delivery system according to the present invention does not show any crystallization of donepezil in the formulation, can release donepezil at a uniform rate for a long time, and can inhibit the release dumping phenomenon that occurs in a transdermal delivery system having a single-layer structure.
    Type: Application
    Filed: February 26, 2013
    Publication date: February 12, 2015
    Applicant: SK Chemicals Co., Ltd.
    Inventors: Jong-Seob Im, Yong-Youn Hwang, Won-No Youn, Yeo-Jin Park, Hye-Min Kim, Joon-Gyo Oh, Hun-Taek Kim, Bong-Yong Lee
  • Publication number: 20150045748
    Abstract: The present invention relates to a transdermal device including porous microparticles capable of containing an active principle, in particular nicotine, and to the use thereof as a drug, in particular for tobacco cessation. The present invention further relates to a method for preparing a transdermal device including porous microparticles filled with an active principle.
    Type: Application
    Filed: February 28, 2013
    Publication date: February 12, 2015
    Inventors: Isabel Ribeiro Dos Santos, Michel Sournac
  • Patent number: 8945074
    Abstract: A device for use with a negative pressure bandage for supply negative pressure. The device includes a pump module and a controller module. The pump module contains a power source and a pump. The pump module is removably contained in the controller module. The pump module and controller module can be connected with a connector that provides both a physical and pneumatic connection. The controller module may include one of more visual indicators for allowing the status of the device to be observed at a distance.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: February 3, 2015
    Assignee: Kalypto Medical, Inc.
    Inventors: John Buan, Alan Carlson, Daniel Gelfman
  • Publication number: 20150025480
    Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 22, 2015
    Inventors: Adam S. Cantor, Terrance W. Ocheltree, Cynthia A. Robles
  • Publication number: 20150024028
    Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 22, 2015
    Inventors: Thomas Hille, Lothar Deurer
  • Publication number: 20150018782
    Abstract: A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl(meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxyl group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.
    Type: Application
    Filed: September 25, 2014
    Publication date: January 15, 2015
    Inventors: Takao HIRAOKA, Shuta NAKANAMI, Toru KOGA
  • Publication number: 20140378917
    Abstract: The present invention provides transdermal therapeutic systems for dispensing a pharmaceutical product, in particular a pharmaceutical product with a low tendency to spontaneously crystallize. The matrix layer or at least one of the matrix layers in said systems contains a silicone hot-melt adhesive, a pharmaceutical product, and particles made of crosslinked polyvinylpyrrolidone. The invention also relates to a method for producing said transdermal therapeutic systems.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 25, 2014
    Inventors: Horst Dzekan, Hans-Rainer Hoffmann, Michael Horstmann, Walter Mueller, Sandra Wiedersberg
  • Publication number: 20140370077
    Abstract: The present invention provides a transdermal drug delivery system comprising fentanyl or its pharmaceutically acceptable salt and method of making the same.
    Type: Application
    Filed: March 12, 2014
    Publication date: December 18, 2014
    Inventors: Hoo-Kyun Choi, Je Phil Ryoo
  • Publication number: 20140371692
    Abstract: Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto.
    Type: Application
    Filed: April 29, 2014
    Publication date: December 18, 2014
    Applicants: A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS RUSSIAN ACADEMY OF SCIENCES, CORIUM INTERNATIONAL, INC.
    Inventors: Gary W. Cleary, Shoreh Parandoosh, Mikhail M. Feldstein, Anatoly E. Chalykh, Nicolai A. Platè, Valery G. Kulichikhin
  • Publication number: 20140370076
    Abstract: The present invention provides a transdermal drug delivery system comprising donepezil or its pharmaceutically acceptable salt and method of making the same.
    Type: Application
    Filed: March 12, 2014
    Publication date: December 18, 2014
    Inventors: Hoo-Kyun Choi, Myung-Kwan Chun
  • Publication number: 20140371693
    Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
    Type: Application
    Filed: July 8, 2014
    Publication date: December 18, 2014
    Inventors: Kiyomi TSURUDA, Shinji YAMASOTO, Kouki SHOHO, Masaru NAKANISHI
  • Publication number: 20140363487
    Abstract: The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a bupreno?hine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact la
    Type: Application
    Filed: December 12, 2012
    Publication date: December 11, 2014
    Inventors: Thomas Hille, Gabriel Wauer, Kevin John Smith, Helen Elizabeth Johnson, Gillian Elizabeth Mundin
  • Publication number: 20140358094
    Abstract: The present invention is a herbal composition and method of preparing thereof. The herbal composition comprising extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR). The present invention also relates to an oil-in-water or water-in-oil type nano-emulsion and method of preparing thereof. The nano-emulsion comprises an aqueous phase, an organic phase and a surfactant, wherein said aqueous phase comprises hydrophilic extract of herbal materials and said organic phase comprises hydrophobic extract of said herbal materials. The present invention also relates to a transdermal patch comprises said nano-emulsion. The herbal composition of the present invention is useful in treating traumatic injuries, in particular bone injuries. The present nano-emulsion and patch thereof can promote skin absorption of active ingredients in herb, thereby increasing the herb's bioavailability and efficacy in therapy.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 4, 2014
    Applicant: Nano and Advanced Materials Institute Limited
    Inventors: Ka Wing LAM, Chun Hay KO, Wing Sum SIU, Clara Bik San LAU, Tai Wai David LAU, Kam Ming KO, Ka Ming NG, Ping Chung LEUNG
  • Patent number: 8900217
    Abstract: According to an embodiment of the present disclosure, a wound dressing system is presented. The wound dressing system includes a fluid permeable support layer, the support layer configured for positioning within a wound and adapted to generally conform to a topography of the wound, and to permit exudates from the wound to pass therethrough. The wound dressing system further includes a plurality of beads supported by the support layer, the beads defining an insulated inter-connected elongate member and an electrode embedded within and extending through at least a portion of the elongate member. Also, a current is generated by an external energy source that electrically flows through the electrode.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: December 2, 2014
    Assignee: Covidien LP
    Inventor: Arnaz Malhi
  • Publication number: 20140350493
    Abstract: This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the Al layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.
    Type: Application
    Filed: April 29, 2014
    Publication date: November 27, 2014
    Applicant: Agile Therapeutics, Inc.
    Inventors: Agis KYDONIEUS, Robert G. CONWAY, Thomas M. ROSSI