Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the suprachoroidal space (SCS). The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.

Abstract: A wound debridement system includes a wound dressing having an active layer and a wound interface layer. The active layer is formed from one or more transmission layers that are arranged about a central post. Activation of the transmission layers is configured to cause the movement of the wound interface layer relative to a tissue site to which the wound dressing is applied. A drive unit is operably attached to the central post. The drive unit is configured to generate and transfer a vibrational energy and/or a rotational movement to the transmission layer(s) via the central post. The resultant vibration and/or rotation of the transmission layer(s) is imparted onto the wound interface layer, thereby effectuating the desired movement of the wound interface layer relative to the tissue site, which allows for the debridement of debris that may be located at the tissue site.

Abstract: An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.

Abstract: An external catheter is provided. The external catheter has a planar base having a central aperture therethrough. A back surface of the planar base has an adhesive material that be used to removably secure the planar base of the device to the skin of a user. A tubular member is disposed on the front side of the planar base about the central aperture. The tubular member is composed of materials that enable fluid to be stored therein without leaking. A vent is disposed on the front surface of the tubular member to enable air to flow and reduce moisture in the area. A sealable drain located at a terminal end of the tubular member enables the fluid to be drained from the tubular member. The device can be used to capture and store bodily fluids and is especially useful for people who experience urinary incontinence.

Abstract: An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to the console and controlled by the user input device. The manifold system is configured to hold releasably a plurality of fluid sources and deliver fluid from at least one of the plurality of fluid sources to the handpiece assembly.

Abstract: A fluid management and medical device system may include a fluid management system and a medical device having one or more sensors proximate the distal end of the elongate shaft of the medical device. The controller of the fluid management system may be configured to calculate a fluid deficit when the distal end of the elongate shaft is disposed within a patient and configured to automatically pause fluid deficit calculation when the distal end of the elongate shaft is removed from the patient. In some instances the controller is configured to calculate the fluid deficit using rotational speed of the inflow pump in combination with a difference between a change in weight of a fluid supply source supplying fluid to the fluid management system and a change in weight of a collection container collecting fluid from the fluid management system.

Abstract: A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

Abstract: Disclosed is a liquid removal drypad and liquid removal system suitable for absorbing and removing liquid produced by an individual. The drypad can include one or more perforated conduits arranged with an absorbent material. A source of reduced pressure can be connected to the one or more perforated conduits to remove liquid from the drypad. The drypad can be positioned under a patient and liquid produced by the individual can be removed by applying reduced pressure to the drypad. The drypad can be made by combining one or more conduits with an absorbent material.

Abstract: Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.

Abstract: A wound therapy apparatus is disclosed that includes a wound interface securable to a skin surface around a wound bed to form an enclosed space over the wound bed that is fluid-tight. The wound therapy apparatus may include a dressing engaged with the wound interface to contact the wound bed. A spacer may be disposed within the enclosed space proximal of the dressing to define a plenum between portions of the wound interface and a proximal side of the dressing. Gas within the enclosed space may have an O2 concentration greater than the O2 concentration in atmospheric air. The dressing may include a hydrophobic material, a hydrophilic material, or a distal layer comprised of silicone having fenestrations therein, in various aspects. The pressure p0 within the enclosed space may vary over a pressure range Pmin?P0?Pmax. Related methods of use are also disclosed.

Abstract: The present invention relates to apparatuses and methods for treating a wound by applying reduced or negative pressure to the wound. The apparatus can include a wound cover, a fluid collection container, a vacuum pump, an inflation pump, and one or more conduits. The wound cover can be configured to move between at least a relatively rigid, generally raised position and a relatively flexible, generally collapsed position according to a predetermined program or in response to input from a user or one or more sensors. In some embodiments, the wound cover can be configured to move between at least the relatively rigid, generally raised position and the relatively flexible, generally collapsed position by adjusting the air pressure in one or more channels in the wound cover or by adjusting the length of piezoelectric or other length changing material supported by the wound cover.

Abstract: The present disclosure relates method of tanning a person including applying a moisturizer to an applicator and applying a tanning solution to the applicator. The moisturizer and the tanning solution are applied to the applicator in separate steps. The applicator is then contacted onto the skin of a person to apply the moisturizer and tanning solution.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: An ultraviolet sanitizing apparatus for elimination of germs, viruses, and bacteria includes a housing having a receiving cavity extending from a housing front side through a housing back side. A plurality of LED ultraviolet lights is coupled to the housing within the receiving cavity on each of a cavity bottom side, a cavity top side, a cavity left side, and a cavity right side. A power source is coupled to the housing and is in operational communication with the plurality of LED ultraviolet lights. A motion sensor is coupled to the housing. The motion sensor is coupled within the receiving cavity and is in operational communication with the power source to activate the LED ultraviolet lights when triggered.

Abstract: A neurosurgical ultrasonic focusing assisted three-stage atomization cooling and postoperative wound film forming device has a transducer housing and a nozzle, wherein a horn is arranged in the transducer housing, at least two layers of piezoelectric ceramic sheets are arranged at the top of the horn, an electrode sheet connected with an ultrasonic generator is arranged between two adjacent layers of piezoelectric ceramic sheets, the bottom of the transducer housing is of a hemispherical structure, and a plurality of piezoelectric elements connected with the ultrasonic generator are arranged inside the hemispherical structure; and the nozzle is arranged at the bottom of the horn and connected with a medical nanofluid storage cup, compressed gas can also be introduced into the nozzle, and an electrode is also arranged inside the nozzle.

Abstract: Disclosed is an iontophoresis-based patch type skin care device for allowing a functional substance for skin care to be effectively absorbed into a user's skin by causing iontophoresis on the user's skin through a conductive patch. The iontophoresis-based patch type skin care device for allowing the functional substance for the skin care to be absorbed into the user's skin by the iontophoresis includes a skin care device body that generates power to cause the iontophoresis. The skin care device body includes a power circuit that is provided in an interior space of a body and that includes a power unit that generates the power for the iontophoresis and one or more electrodes to which the power is applied, and a bridge that is provided so as to be combinable with the body and that receives the power through the one or more electrodes.

Abstract: A cartridge acting as a dispenser for liquid treatments of a human or animal body is U shaped or hoop shape. The cartridge has a container containing a liquid treatment which when required to be dispensed is ejected through one or more nozzles projecting through the wall of the cartridge into the centre of the U or of the hoop. A base is provided for cartridges, the base controlling timing and quantity of treatments.

Abstract: Methods and apparatuses are disclosed for applying negative pressure to a wound site. In some embodiments, the apparatus comprises a source of negative pressure, a processing element, and a memory comprising instructions configured to, when executed on the processing element, cause the apparatus to attempt to generate, via the source of negative pressure, a desired negative pressure at the wound site. If the desired negative pressure has not been generated after a first predetermined period of time, the instructions cause the apparatus to: deactivate the source of negative pressure for a second predetermined period of time, and subsequently attempt to generate the desired negative pressure at the wound site.

Abstract: A medical implant for treating bone defects. The implant has at least one hollow body delimiting an inner chamber in the interior of the hollow body, a fluid feed line connected in a fluid-permeable manner with the inner chamber, and a fluid discharge line connected in a fluid-permeable manner with the inner chamber. The hollow body consists at least in places or wholly of at least one plastic material that is impermeable to liquids and permeable to oxygen and to carbon dioxide, such that oxygen is deliverable from a fluid passed through the hollow body to, and carbon dioxide is absorbable into the fluid from, the surroundings of the hollow body. Also disclosed is a bone defect treatment system having such a medical implant and the fluid, wherein the fluid contains oxygen and is suitable for absorbing oxygen, and to a method for gas-flushing a surface of a medical implant.

Abstract: An applicator for pasty cosmetic products that allows a better handling of the applicator in order to significantly improve the distribution of the cosmetic product during its application, and in turn, avoids “getting dirty” and/or “stained” with the cosmetic product or contaminating the same during its handling, thanks to the fact that it has separate sectors each with different purposes and a removable laminar cover that covers the entire applicator.

Abstract: A dressing assembly for use with a reduced pressure treatment system, the dressing assembly develops a directed force under reduced pressure. The directed force may be a radial force or a closing force. The dressing assembly includes a shaped dressing bolster having a shaped extremity that is operable to evenly deliver the radial force and to distribute reduced pressure. Numerous shapes may be used for the shaped extremity. The dressing assembly may further include an over-drape to assist in creating a seal over the shaped dressing bolster and against a portion of a patient's epidermis.

Abstract: An applicator device allows for independent application of topical substances onto patients' skin, allowing self-application to difficult-to-reach areas. The applicator device includes a handle, an articulating segment, and an applicator head. The handle extends to a rotating joint between the handle and the articulating segment. A user activates the handle that operates to deliver the topical substance from an incorporation portion of the articulating segment to the applicator head and to the patient. The device meters the dispensed doses. The device can use disposable foam applicator pads and comes in a sleek, modern, ergonomic design. The device articulates and folds and rotates to provide easy access to previously hard-to-reach patient areas. The device can be easily stored, cleaned, and disinfected. The device prevents wasting of substances and solves the problem of overuse of topical medications, which can lead to adverse side effects.

Abstract: An all-in-one, sterile, waste- and mess-free device for cleaning two-sided bodily punctures is described. The device may be a hand-held device that encloses around both sides of a two-sided bodily puncture and provides targeted cleaning fluid soaking, fully or partially submerged, without the user ever needing to touch or disturb jewelry in the two-sided bodily puncture. Cleaning fluid soaking involves cleaning fluid, without elevated pressure, soakingly contacting a two-sided bodily puncture to: (1) kill microorganisms in the area surrounding the two-sided bodily puncture (e.g., skin surrounding openings of the two-sided bodily puncture); and/or (2) remove cellular debris and/or microorganisms from the area surrounding the two-sided bodily puncture.

Abstract: The present disclosure relates to a medicament delivery device. The medicament delivery device comprises a housing, a dispensing mechanism and an actuator. The housing has first and second portions. The dispensing mechanism comprises a reservoir disposed in the housing. The dispensing mechanism is operable to dispense medicament from the reservoir when the reservoir contains medicament. The first portion of the housing comprises a distal end and the second portion is moveable towards the distal end from an initial position to a primed position. The dispensing mechanism is rendered inoperable when the second portion is in the initial portion. The actuator is actuatable to operate the dispensing mechanism when the second portion is in the primed position.

Abstract: A Negative Pressure Wound Therapy (NPWT) dressing having a sealing layer on a non-wound interfacing surface. Such a sealed surface eases application and reduces the risk of a loss of seal once applied to a patient. Associated adaptors and couplers, which may be universal couplers, allow for simplified use of the disclosed and existing dressings. An optional pressure regulator unit may use existing wall suction available in medical facilities; it may interface with a transportation unit. Embodiments of the regulation unit provide for various monitoring, operation and alarming features that may be accessed using mobile wireless, wireless LAN, and internet based connectivity approaches.

Abstract: According to some embodiments, a skin treatment assembly comprises a tip comprising a proximal end and a distal end, a container configured to secure to the tip along the proximal end of the tip, wherein the container is configured to contain a liquid, and a porous member configured to extend at least partially within an interior of the container such that it contact a liquid contained within the container, wherein the porous member is configured to extend at least partially within an interior of the tip and is configured to facilitate the transfer of liquid from the container to the distal end of the tip.

Abstract: Methods, apparatuses and systems are described for delivering a stent through an access hole of a body lumen and covering up the access hole after deploying the stent, Stents are described that include a stent body defining a body lumen contact surface area and a deployable member configured to deploy from the stent body and increase the body lumen contact surface area of the stent. Deployable members that hinge, unroll, extend, expand, and coaxially translate with respect to the stent body are described. A system for delivering a stent into a body lumen are described that may include a coverage member configured to at least partially cover the hole in the wall of the stent upon withdrawing a tubular member through the hole in the wall of the stent. Coverage members may include a self-sealing membrane, a flap valve, or a hinged valve.

Abstract: Apparatuses and methods disclosed herein relate to various embodiments of wound fillers that, in some cases, preferentially collapse in one direction as compared to another direction. Such apparatuses and methods may aid in the closure of wounds and may further be used in combination with pressure sensors and controllers to provide for controlled collapse of the wound fillers.

Abstract: An irrigator system for delivering a volume of fluid from a fluid source to an abscess or wound. The irrigator system includes a fluid source connector for removably connecting to the fluid source, a fluid delivery nozzle for delivering the fluid to the abscess or wound, and a shield removably positioned around the fluid delivery nozzle to protect the fluid delivery nozzle.

Abstract: Described herein are devices and methods for vascular access via the tributaries. A single lumen catheter, with a bidirectional valve at the tip is disclosed. Flow is out the longitudinal tip of the catheter and not the sides. The two-way valve will act passively but has low opening and closing pressures. A method utilizing endo-to-side port placement of said catheter in vasculature is disclosed. Anastomosis methods are described using said catheter.

Abstract: A treatment system including one or more of a wound dressing having one or more of a substrate element, a dressing member disposed on the substrate element, an adhesive element disposed on the substrate element, and a tether connecting the wound dressing to a treatment device.

Abstract: A cosmetic composition for brightening skin and a method for brightening skin using the cosmetic composition are provided. The cosmetic composition has a pH<7, and includes an oxidizing agent, in some embodiments comprising hydrogen peroxide, and at least one fatty compound present from about at least 30% by weight, based upon the total weight of the composition. The method for brightening skin includes applying to the skin a composition provided as a single-part system, the system including the oxidizing agent and a fatty compound component.

Abstract: A system for treating a deep abdominal wound. The system includes a wound dressing. The wound dressing includes a visceral-protective layer, a compressive layer, and a sealing layer. The visceral-protective layer is configured to be positioned in an open abdomen. The compressive layer is configured to be disposed proximate to the visceral-protective layer. The compressive layer includes a pattern of voids configured for anisotropic collapse of the compressive layer when under negative pressure. The sealing layer is configured to form a sealed space in the open abdomen. A negative pressure source configured to provide negative pressure to the compressive layer.

Abstract: Described here are devices, systems, and methods for treating meibomian gland disease and/or blepharitis by providing intranasal stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may unblock obstructed meibomian glands and increase the lipid content of tears, both acutely during stimulation and subsequent to intranasal stimulation. The methods may include an initial round of stimulation to unblock obstructed meibomian glands, and subsequent shorter rounds of stimulation to cause meibum secretion and maintain the open glands.

Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.

Abstract: Embodiments of the present invention are directed to methods and articles of manufacture to treat skin to improve and/or increase hydration, pliability, and thickness for improved texture, feel and appearance. Embodiments feature applying an effective amount of an acetylation agent to natural dermal collagen under reaction conditions to react the natural dermal collagen with the acetylation agent to form a modified collagen. The modified collagen has a higher net charge and higher net charge density than natural dermal collagen. The modified collagen improves or increases one or more skin characteristics consisting of hydration, pliability and thickness.

Abstract: Methods and systems for performing laser-assisted surgery on an eye form one or more small anchoring capsulotomies in the lens capsule of the eye. The one or more anchoring capsulotomies are configured to accommodate corresponding anchoring features of an intraocular lens and/or to accommodate one or more drug-eluting members. A method for performing laser-assisted eye surgery on an eye having a lens capsule includes forming an anchoring capsulotomy in the lens capsule and coupling an anchoring feature of the intraocular lens with the anchoring capsulotomy. The anchoring capsulotomy is formed by using a laser to incise the lens capsule. The anchoring feature can protrude transverse to a surface of the intraocular lens that interfaces with the lens capsule adjacent to the anchoring capsulotomy.

Abstract: An apparatus (100) to maintain an environment over an anterior surface of a patient eye can include an enclosure (110) sized and shaped to be seated about the patient eye to form a cavity (112) within the enclosure. The enclosure can be configured to contain a fluid other than ambient air in contact with the patient eye. The apparatus can include a fluid regulator (1209) in communication with the enclosure, where the fluid regulator can be configured to regulate the composition of the fluid contained within the enclosure.

Abstract: An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.

Abstract: Wound pads and systems and kits comprising wound pads whose total thickness can be modified by a user without the use of tools, comprising a plurality of separable layers having layer thicknesses less than the thickness of the wound pad. The wound pads may be used as wound fillers in the context of negative pressure wound therapy (also known as “vacuum treatment”, “reduced pressure” treatment).

Abstract: A tympanostomy tube delivery device comprises a shaft assembly, a pressure equalization tube, and a trigger assembly. The shaft assembly comprises a cannula and a pusher operable to translate relative to the cannula. The pressure equalization tube is positioned within the shaft assembly. The pusher is operable to drive the pressure equalization tube out of the shaft assembly. The trigger assembly includes a pair of pushbuttons and a linkage. The pushbuttons are secured to the device via living hinges and are selectively pivotable. The linkage is configured to engage the delivery device to thereby selectively prevent actuation of the delivery device. The pivoting of one or both the pushbuttons is configured cause the linkage to collapse so as to disengage the delivery device and thereby actuate the delivery device.

Abstract: A protective perineal pad for use in lower limb procedures includes a wedge-shaped body having a top, a bottom, opposed sides, and a front and opposed back. A cavity extends into the body from a flat seat at the top, so that, when the pad is used with a patient, the cavity is disposed over a perineal area of the patient.

Abstract: A bite block for use in a mouth of a patient to hold the mouth in a spaced-apart position that includes a condensed fiber block having a predetermined length suitable for being inserted into the mouth of the patient and positioned between upper and lower molars and a wrapper yarn repeatedly wrapped around the block along its length. An adhesive strand in the wrapper yarn is positioned on an outer surface of the fiber to maintain the block in its condensed state.

Abstract: An irrigator system for delivering a volume of fluid from a fluid source to an abscess or wound. The irrigator system includes a fluid source connector for removably connecting to the fluid source, a fluid receiver for receiving the fluid from the fluid source, a fluid delivery nozzle for delivering the fluid to the abscess or wound, and a shield removably positioned around the fluid delivery nozzle to protect the fluid delivery nozzle.

Abstract: A treatment system including one or more of a wound dressing having one or more of a substrate element, a dressing member disposed on the substrate element, an adhesive element disposed on the substrate element, and a tether connecting the wound dressing to a treatment device.

Abstract: This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.

Abstract: The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue grasping elements to apply a wound closing force to the tissue.

Abstract: An irrigator system for delivering a volume of fluid from a fluid source to an abscess or wound. The irrigator system includes a fluid source connector for removably connecting to the fluid source, a fluid receiver for receiving the fluid from the fluid source, a fluid delivery nozzle for delivering the fluid to the abscess or wound, and a shield removably positioned around the fluid delivery nozzle to protect the fluid delivery nozzle.

Abstract: A wound treatment system includes a housing. A processor is located in the housing. A pressure monitoring system is coupled to the processor. A power delivery system is located in the housing and coupled to the processor. An oxygen concentrator is located in the housing and coupled to the power delivery system. The oxygen concentrator includes a plurality of oxygen outlets. The processor is configured to receive pressure information from the pressure monitoring system that is indicative of a pressure in a restricted airflow enclosure provided by a dressing and located adjacent a wound site; and use the pressure information to control the power provided from the power delivery system to the oxygen concentrator in order to control an oxygen flow created by the oxygen concentrator and provided through one of the plurality of oxygen outlets to the restricted airflow enclosure.