Abstract: A wound anchor sterile pen (WASP), and a system and method for administering to wounds of mass casualties using multiple WASPs. This system has tactical, EMS, Mass Casualty, disaster, lay-responder and self-use in mind. It is also designed to allow tracking using RFID tags and Blockchain technology. It is a needed product for treating mass casualties in combat as well as in shooting situations such as those that have recently occurred at schools, night clubs and other large gatherings. The device can assist in stopping blood flow from wounds and give the injured person more time to obtain hospital treatment to hopefully preserve the person’s life.

Abstract: A paint applicator, kit and methodology for using the same is disclosed. For example, a paint applicator that allows a user to load a desired amount of paint, such as a water based or other low VOC paint, into the paint applicator and an advancement mechanism that dispenses paint at a rate controllable by the user is disclosed. The advancement mechanism can include a system that translates a rotational force applied to an end cap of the applicator into a linear force that advances a piston which in turn applies paint to an applicator portion. The paint applicator may be reusable or may include a ratchet system that allows for only one time use. The methodology and kit can incorporate a syringe for loading paint into the paint applicator, thus reducing the loss of paint through spilling.

Abstract: A device for holding a liquid or pasty mass that can be dispensed from an insertable container by a dispensing device that is part of a first assembly that can be connected with a second assembly that is vertically below the first assembly in an axial direction and has a lower housing part that accommodates the insertable container. First connecting elements allocated to the first assembly are tethered with second connecting elements allocated to the second assembly. The connection that connects the first connecting element carrier with the second connecting element carrier is more easily undone than the positive or latched connection generated during a joining step, which was used to connect the first assembly with the second assembly with an axial force in the vertical direction. The connecting elements have latching teeth that run axially relative to the assembly direction in which the joining step takes place, and mesh into each other in the joining process.

Abstract: Described herein is an automated fluid drain control apparatus and method which comprises a first collection chamber which is connected to a drain that has been inserted into the subarachnoid area in lumbar region of the body. The volume of fluid into the first collection chamber is controlled as a function of time by being constantly measured such that too much fluid will not be drained from the body.

Abstract: A hand-held applicator (10) for self-administration of a semi-solid medicament comprises an applicator head (14) with one or more elongate dispensing nozzles (40) and an applicator body (12) for housing a medicament reservoir, such as a cartridge (20). The applicator has a pump assembly and an actuator (30) for pumping the medicament from the one or more of the dispensing nozzles. The applicator head and applicator body are fixed relative to each other in use such that movement of the nozzle or nozzles away from the scalp or other body area during actuation may be avoided. The applicator may further include an application face for spreading medicament over a body area thereby enabling dual functionality as a scalp and body applicator. A dispensing system in the form of a dispensing head and cartridge therefor is also described and characterised by venting features for improving priming of the dispenser. Such priming means are suitable for use in the applicators of the application.

Abstract: A medical spraying device and method for irrigating a wound, in particular lavage system, having a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir, and a compressed gas reservoir. The compressed gas reservoir is connected or connectable via a pressure line to the liquid reservoir, such that the irrigation liquid can be pushed by the gas pressure of the compressed gas reservoir acting on the irrigation liquid through a nozzle in order to produce a spray cone. A pressure reduction valve is arranged in the pressure line and limits the gas pressure acting in the liquid reservoir on the irrigation liquid. The device and method produce a spray cone of a medical irrigation liquid in which a gas pressure is limited using a pressure reduction valve, wherein the gas pressure limited by the pressure reduction valve is conveyed through a pressure line to a liquid reservoir of the medical irrigation liquid.

Abstract: A medical spraying device and method, for irrigating a wound, having a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir and an arrangement for applying pressure to the medical irrigation liquid, such that the irrigation liquid is pushable through a nozzle by the pressure acting on the irrigation liquid in order to produce a spray cone. The nozzle has a plurality of openings, which are arranged at an angle to one another in such a way that the irrigation liquid jets exiting from the openings, at a such flow rate and angle, meet in an atomisation space and/or a discharge opening of the nozzle; thus, a spray cone is produced from the atomised irrigation liquid.

Abstract: Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.

Abstract: An applicator for topically applying a semi-solid medicament comprises an applicator head having an applicator face for spreading medicament across the skin; a sealable aperture on the applicator face; and a drive mechanism for forcing medicament out through the aperture. The applicator head includes a cartridge port at the rear of the applicator face for receiving a dispensing end of a cartridge charged with medicament. The drive mechanism comprises a dial knob rotatable around a longitudinal axis of the applicator for advancing a piston along a drive member towards the applicator head to force medicament from the cartridge and thereby dispense a predetermined dose of medicament onto the applicator face.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: Apparatus and methods for reconstituting and/or removing lyophilized and/or vialed drugs for topical application includes a syringe having a removable plunger. A vial extraction adapter can interconnect the syringe and a vial, allowing a user to transfer a reconstituting solution from the syringe to the vial. After appropriate mixing, the user can then easily remove the reconstituted drug solution from the vial into the syringe. A cap can then be placed on that end of the syringe and the plunger of the syringe can be removed. An application adapter can be placed over the opening from which the plunger was removed. A cap of the application adapter can cover an applicator end that can be used to apply the liquid drug substance from the syringe. The cap of the application adapter can be replaced and any unused drug produced can be stored until needed again.

Abstract: A method and apparatus for measuring a volume of a wound are described, the method comprising the steps of: applying a dressing over a wound, the volume of which is to be measured, the dressing including at least a sealing drape over the wound so as to create a sealed wound cavity; creating a vacuum in said wound cavity by vacuum pump means so as to produce a predetermined vacuum in the wound cavity; measuring a volume of air extracted from said wound cavity in producing said predetermined vacuum; and, calculating a volume of said wound.

Abstract: A multi-dose, metered dispenser and applicator for topical medications includes inner and outer cylinders and a plurality of expanding bases. These bases form part of a telescopic piston drive system that advances the main piston through the inner cylinder, in accordance with a selected dosage, to dispense a metered amount of the topical medication. The dosage may be selected by a switch located on an outside of the outer cylinder, and dispensed by rotating the inner cylinder relative to the outer cylinder. A tactile and audible feedback mechanism informs the user that the desired dosage of medication has been dispensed.

Abstract: Aspects of the present invention concern the discovery of a transdermal delivery composition that can deliver low, medium and high molecular weight pharmaceuticals and cosmetic agents. Embodiments include transdermal delivery compositions with therapeutic and cosmetic application, transdermal delivery devices for providing said transdermal delivery compositions to subjects in need thereof, and methods of making and using of the foregoing.

Abstract: Irrigation systems having splash shields attachable to bottles or syringes, also including abscess irrigation systems.

Abstract: Internally pierced formed blisters containing fluid compositions for use in devices to produce a spray or mist delivery of the compositions include internal piercing nozzles that can have significantly reduced channel volume to increase pressure of the fluid forced through the nozzle and provide finer control of spray geometry.

Abstract: A micro toothed cap device with a cavity can penetrate through a hair weave to exfoliate and stimulate the scalp. The device can be used to apply medicated products directly into the hard-to-reach areas under a hair weave to easily access the scalp. The device is small enough to penetrate to the undergrowth under the plaits, cornrows and wefts, allowing the scalp to be exfoliated, cleansed and treated properly without shifting the weft out of place.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A dental package and a method of making such dental package for holding flowable dental material. The method comprising the steps of providing a container having an opening and providing first portion of a flowable dental material in the container. Further the method comprises hardening a predetermined second portion of the flowable dental material to form a closure that closes the opening. The invention provides for improved manufacturing and for facilitating the use of the package.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound is provided. The system includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, and a collection canister in fluid communication with the wound dressing. The canister includes a base defining a fluid receiving cavity and having a fluid inlet port and a vacuum port. The fluid inlet port is configured for fluid communication with a wound dressing, The system further includes a cover selectively engageable to the base, e.g., in a snap-fit manner. The cover is configured to receive a control unit and has a vent assembly for exhausting the control unit. A seal member is interposed relative to the base and the cover to establish and maintain a substantial sealed relationship between the two components when assembled.

Abstract: Apparatus (130) for use in wound therapy of mammals is described, the apparatus (130) comprising: a dressing covering the wound, the dressing being substantially sealed to prevent ingress of ambient atmospheric air to the wound; aspiration means (132) operably connected to a space between the dressing and the wound by an aspiration conduit (142) sealed to the point of entry between wound and dressing against ingress of ambient atmosphere, said conduit (142) being for aspiration of said wound and for removal of fluid from said space between said wound and said dressing; a waste container (148) for receiving aspirated fluid to be discarded operably connected to said aspiration conduit; and heating means (144) for heating said fluid in order to increase the vapor pressure thereof and to cause evaporation to reduce the volume of the fluid in the waste container (148). In a preferred embodiment of the present invention the waste fluid is also provided with a sparge gas.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A clip receives a barrel of the syringe. The clip includes a receptacle portion receiving a pre-filled cannister of a topical numbing agent, wherein the cannister includes a generally cylindrical chamber portion receivable within the receptacle portion of the clip and a distal neck portion having an outlet allowing contents of the cannister to be dispensed. A dispenser attached to the distal neck portion of the cannister includes an elongated flexible tube surrounded by a rigid tube for at least a portion of a length of the elongated flexible tube. A pivotable lever carries a tube compressor including a pinching member extending through an opening in the rigid tube and spring biased to a position at which the pinching member pinches closed an elongated passageway through the flexible tube.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A pair of clips receive a barrel of the syringe. The clips are on a housing receiving a pre-filled cannister of a topical numbing agent and including a chamber. The cannister includes an aerosol dispensing valve actuated by a button which when pressed moves the cannister with respect to an actuator for the valve.

Abstract: An aspiration flow control device includes a housing having at least one vacuum port, at least one aspiration port, and an ejection port. The at least one vacuum port is adapted to be connected to a vacuum source, and the aspiration port is adapted to be connected to an aspiration line for receiving fluids from a surgical site. The device further includes a rotating structure having at least three vanes, which structure is configured to rotate within the housing. The at least three vanes divide an enclosed volume within the housing into at least three rotating fluid collection chambers. During rotation of the rotating structure, at least one fluid collection chamber is in communication with at least one vacuum port and the aspiration port through which fluid is received, and at least one other fluid collection chamber is simultaneously in communication with the ejection port through which fluid is expelled.

Abstract: Embodiments provide a medical device in the form of an applicator for applying a medical composition to a patient. The applicator includes a body, a tip, and a delivery mechanism. The body defines a storage chamber for the medical composition and has an opening for deploying the medical composition from the storage chamber. The tip covers the opening and has a closed state wherein the tip maintains the medical composition in the storage chamber and an open state wherein the medical composition can be deployed through the opening and the tip.

Abstract: Described herein is an automated fluid drain control apparatus and method which comprises a first collection chamber which is connected to a drain that has been inserted into the subarachnoid area in lumbar region of the body. The volume of fluid into the first collection chamber is controlled as a function of time by being constantly measured such that too much fluid will not be drained from the body.

Abstract: A device for delivering an active agent to a tissue (100), comprising; a housing (10) including a reservoir (20) for containing said active agent; a delivery tip (35) being in fluid communication with said reservoir; and, a delivery mechanism (40) capable of delivering a predetermined amount of said active agent and releasing the same upon contact between said delivery tip and said tissue.

Abstract: Disclosed herein are devices, systems and methods for using such devices and systems for treating incisions and wounds. In an aspect, disclosed is a device having a generally planar tension relief module and a flexible sealant structure sized to cover the tension relief module, the flexible sealant structure comprising a lower adhesive surface. The tension relief module includes a conduit structure having a plurality of support structures on an upper surface of the conduit structure and at least one opening extending through the conduit structure from a lower surface to the upper surface. At least a portion of the conduit structure is adapted to be aligned with a longitudinal axis of the incision. The tension relief module also includes opposing adhesive structures coupled to the conduit structure. The lower adhesive surface of the flexible sealant structure and the upper surface of the conduit structure form a flow pathway.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: Disclosed are devices, systems and methods for treating an incision. The device includes a generally planar tension relief module, comprising a central structure in fluid communication with the incision, wherein at least a portion of the central structure is adapted to be aligned with a longitudinal axis of the incision; and opposing adhesive structures coupled to the central structure and a flexible sealant structure comprising a lower adhesive surface and sized to seal over the tension relief module forming a sealed flow pathway. The opposing adhesive structures are adapted to be stretched from a relaxed configuration to a first tensile configuration and to return towards the relaxed configuration from the first tensile configuration into a second tensile configuration and impart a contracting force in a direction that is towards the opposing adhesive structure.

Abstract: A single-use disposable applicator and dispenser of creams, liquids, and spreadable agents. A liquid or cream agent of liquid or viscous is stored in a sterile container. An applicator including a soft interface is stored along with the agent. When the need to apply the agent occurs, the applicator breaks the seal to the agent, after which the applicator is used to apply the cream or liquid agent to a desired surface, and is then discarded. The invention may be used by healthcare providers and similar persons to treat a plurality of persons, and lessens the likelihood that bacteria or infection will be spread amongst a population. The invention may further be used to contain, dispense, and apply any manner of spreadable agents of low rigidity including, but not limited to, soaps, cleaning agents, and paint samples.

Abstract: A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: An apparatus (1) for cleansing wounds (5) in which irrigant fluid from a reservoir connected to a conformable wound dressing (2) and wound exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, and means for supplying thermal energy to the fluid in the wound. The former provides a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting wound healing over the wound bed. The latter maintains a temperature at the wound bed under the wound dressing at a level that promotes wound healing.

Abstract: A dispenser containing a substance to be applied on a patient is described. The dispenser includes a plunger, a tube and a perforated element located inside the tube. The tube contains openings at its application end. When the plunger is pushed during application, the substance is squeezed through the perforated element and the openings and is applied to the patient. Selection of the height of the perforated element and presence or absence of alignment between the perforations of the perforated element and the openings allows control of the application of the substance on the patient.

Abstract: Apparatus for the provision of topical negative pressure therapy to a user is described, the apparatus comprising a device and a waste canister connected thereto, the waste 5 canister being operably connected for receiving wound exudate to a wound dressing by an aspiration conduit which is releasably connected to the dressing, wherein the waste canister has a blank connector portion thereon for sealably receiving a disconnected dressing end of the aspiration conduit.

Abstract: The present invention is directed to a delivery device and method for the sequential delivery of a topical pain relieving composition and an occluding composition. These two compositions are held in a single device that comprises at least two chambers for manual and or pressurized delivery of these compositions to the patient's skin.

Abstract: The present invention relates to a device for delivery of medicament comprising a main housing; a container arranged in said housing and arranged to be connected to a medicament delivery member, wherein said container includes at least two chambers and at least one longitudinally movable plunger and wherein at least one chamber contains a medicament agent; a pre-treating arrangement acting on said container; drive force means acting on a longitudinally movable plunger rod capable of exerting a force on said container; and activating delivery means acting a said drive force means for delivering medicament via said medicament delivery member characterised in that said pre-treating arrangement comprises clickable means for manually and delay intermittently mixing said medicament agent and for manually priming said container.

Abstract: This invention relates to devices and methods for safely reconstituting and administering topical therapeutic or cosmetic compositions. The topical applicator according to the invention is particularly well suited for storing, reconstituting, and administering or applying highly toxic substances.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A wound dressing for use in negative wound pressure therapy includes a cover layer for positioning over a wound to define a reservoir over the wound in which a reduced pressure may be maintained. At least one vacuum port is affixed to the cover layer and includes a conduit receiving portion configured to receive a fluid conduit to provide fluid communication between the fluid conduit and the reservoir. The at least one vacuum port is configured to receive the fluid conduit from a plurality of directions relative to the cover layer.

Abstract: The present invention is directed to an intermittent aerosol dispensing device, for application of a product to skin of a human being, where the aerosol dispensing device includes an intermittent injection mechanism located downstream of an aerosol valve of an aerosol dispenser and responsive to a pushbutton of the aerosol dispensing device, and the aerosol dispensing device further includes a pressure chamber. A ratio of an injection time to a stop time is set, in said intermittent injection mechanism, to 0.1 to 5.0, so that when said aerosol valve is opened a cycle of injection and stop is performed 1 to 25 times per second in order to obtain a cooling and/or massage effect on the skin.

Abstract: A wound dressing member is provided for use in a vacuum bandage connected to a vacuum source and for use with a wound having a wound surface. The member may include a top surface and a bottom surface adapted to be in contact with and generally conform to the wound surface. The member may further include a plurality of discrete holes formed in the bottom surface and at least one discrete opening formed in the top surface. A port of the member may be provided to communicate with the vacuum source, each discrete hole, and the at least one discrete opening.

Abstract: An apparatus and method for delivering liquid within an orifice of an animal is disclosed. In an exemplary embodiment, the apparatus comprises a hollow syringe defining a vessel having an open end; a plunger, slidingly and sealingly disposed within the vessel; and a flexible delivery tube, having a first end sealingly coupled to the open end and a delivery end for dispensing the liquid proximate the orifice. A light source directing light to the delivery end of the flexible tube may also be included.

Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

Abstract: A tampon assembly used for penetration injuries to provide hemostasis and simultaneous broad spectrum antibiotic/anesthetic application. The tampon includes a helically-wound absorbent member impregnated with coagulant, covered with biodegradable or plastic accordion-pleated sheath including a bioluminescent tape outer marker. The device would also contain a measured dose of antibiotic/anesthetic suspension sealed within the confines of the outer sheath. The outer sheath would preferably have a perforated petal-shaped tip to enable wound insertion followed by through passage of the contained wound packing and treatment liquids/emulsions, etc. A radio opaque cotton withdrawal string would attach to the absorbent member at the end facing the wound opening. An insertion stick/plunger is used for tampon deposition within the wound. Manual pressure on the plunger would cause seal rupture and expulsion of the wound packing and treatment through the ruptured tip of the sheath.

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: Methods and devices transmit micromechanical forces locally on the millimeter to micron scale for promoting wound healing. Micromechanical forces can selectively be applied directly to tissue, in some embodiments, by using microchambers fluidically connected to microchannels. Each chamber, or in some cases, group of chambers, may be associated with a valve to control vacuum pressure, positive pressure, liquid delivery, and/or liquid removal from each chamber or group of chambers. Application of embodiments of the invention may shorten wound-healing time, reduce costs of therapy, enable restoration of functional tissue, and reduce the need for more invasive therapies, including surgery.