Abstract: The present disclosure is directed to a vial adapter for interconnecting a vial and a fluid delivery device, and, more particularly, to a vial adapter having a modular design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new vial adapter configurations that meet specific needs.

Abstract: A blood component collection cassette that can trap a foreign object such as a blood-coagulated clot from blood components to be returned to a blood donor and a manufacturing method of the blood component collection cassette are provided. A sheet-shaped filter member (60) is arranged on a flow path (42) in a cassette main body (40) of a blood component collection cassette (28). A first tube (66) and a second tube (68) are arranged in the cassette main body (40). An inner space (51) of a filter housing unit (54a) is separated by the filter member (60) into a first space (51a) on the side of the first tube (66) and a second space (51b) on the side of the second tube (68).

Abstract: In a blood transfusion system (a blood transfusion kit, a blood transfusion kit for emergency blood transfusion, or a method of using a blood transfusion kit), a flow path through which blood flows is formed using a tube having a channel therein. The flow path includes: a first path that connects an upstream path and a downstream path and has a leukocyte removal filter removing leukocytes at an intermediate position of the channel; and a second path that connects the upstream path and the downstream path and bypasses the leukocyte removal filter.

Abstract: A gas elimination apparatus and a method for use in an intravenous delivery system are provided. The apparatus includes in a fluid inlet coupling a fluid flow into a liquid chamber, a fluid outlet protruding into the liquid chamber, and a flow diversion member proximal to the fluid outlet. The flow diversion member configured to block a direct flow between the fluid inlet and the fluid outlet. The apparatus includes a membrane separating a portion of the liquid chamber from an outer chamber and a gas venting valve fluidically coupling the outer chamber with the atmosphere. The flow diversion member may be mechanically supported by at least one strut or elongate member extending along a flow direction into the liquid chamber.

Abstract: A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.

Abstract: The present disclosure is directed to a vial adapter for interconnecting a vial and a fluid delivery device, and, more particularly, to a vial adapter having a modular design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new vial adapter configurations that meet specific needs.

Abstract: The present application relates generally to a suction regulator device and, more specifically, to a method and system for signaling responsive to sensing that the suction regulator device has become contaminated.

Abstract: An arm (20) that faces a male member (10) is provided with a claw (30) that protrudes toward the male member (10). An adapter (1) can be connected to a female connector with the male member being inserted into the female connector and the claw engaging with the female connector. The arm is elastically deformable so that the claw can move away from the male member. The claw includes a slidable portion (33a) that slides on the female connector during a process in which the adapter is connected to the female connector. The slidable portion moves the claw in a direction away from the male connector while the slidable portion slides on the female connector. A contour shape of the slidable portion seen in a direction that is orthogonal to a central axis (1a) that passes through the male member includes a smooth convex curve.

Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.

Abstract: A device for selectively filtering a substance suctioned from a surgical site includes a valve that may be positioned in a bypass mode and a filtration mode. The valve is placed within a body that includes an inlet and an outlet. In the bypass mode, a first inlet of the valve is adapted to be aligned with the body inlet. The first inlet guides the substance through a bypass passageway to the body outlet. In the bypass mode, a bowl and a filter of the body are sectioned off from a flow path of the filtration device such that the bowl and the filter can be removed without interrupting an application of suction to a surgical site by the filtration device. In a filtration mode, a second inlet of the valve is adapted to be aligned with the body inlet to direct the substance into the filter.

Abstract: A portable apparatus for collection and processing of human biological material, such as containing adipose extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction). The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material. Advancing a hollow member such as a hypodermic needle through the extraction port and into the collection volume pierces the filter with the hollow member, providing a safety feature to prevent reuse of the apparatus. Access ports may be configured for access only from above the container.

Abstract: A blood bag system (10) includes a blood bag (14) to which centrifugal force is provided in a state where whole blood or a blood component is stored, and a first tube (22) that circulates a fluid centrifugally separated from the blood bag (14). The first tube (22) includes an extending portion (112) extending in an approximately perpendicular direction to a centrifugal direction into which the centrifugal force is applied. Further, a branch tube (114) that can store blood existing in the extending portion (112) is provided at a side of the centrifugal direction of the extending portion (112).

Abstract: A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either device within the brain.

Abstract: A vial adapter for side engagement of a vial cap includes a needleless connector having a housing and defining one or more fluid pathways therein; an elongated piercing spike operatively coupled to the needleless connector, the elongated piercing spike having a longitudinal axis and one or more channels for fluid connectivity with the one or more fluid pathways; at least one housing arm coupled to the housing and extending parallel to the longitudinal axis; and a coupling member configured to orthogonally receive a vial cap with respect to the longitudinal axis, the coupling member having a planar surface, an aperture of the planar surface longitudinally aligned with the elongated piercing spike, and at least one support arm extending from the planar surface operatively coupled with the at least one housing arm to allow relative longitudinal movement between the coupling member and the elongated piercing spike.

Abstract: A withdrawal spike unit (200) comprises a withdrawal spike component (30?) and an integrally formed adapter component (60?) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component parts (30?, 60?) makes fully automated manufacture and assembly of assemblies comprising such a withdrawal spike unit (200) coupled to a vial (10) possible. As such, human errors associated with the assembly at the point of use are mitigated.

Abstract: Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth of a vial sealed with a rubber stopper, wherein a puncturing hole is formed in a center part of a cap-shaped housing that is attached to a mouth of the vial, and a rubber membrane is arranged at the puncturing hole so as to form an internal space between facing surfaces of the rubber membrane and the rubber stopper. The rubber membrane has a dome shape that is convex facing the rubber stopper.

Abstract: Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A drip chamber having an upper reservoir that is separated from a lower reservoir via a filter assembly, wherein a distance between the filter assembly and a bottom surface of the drip chamber is selected to prevent dislodged air bubbles of the filter assembly from being drawn into an intravenous fluid line that is coupled to the bottom surface of the drip chamber, during an infusion procedure.

Abstract: Apparatus and methods are disclosed for use during surgical procedures for collecting autologous bone. A preferred bone collection assembly collects bone by compressing blood products away from trapped bone using a press. Such bone collecting assembly is easy and uncomplicated to use, and can be easily integrated into an operation where the need for collection and utilization of autologous bone exists.

Abstract: An anal irrigation system includes a tube attachable between an anal probe and a container, and a displaceable pump element. The container includes an exterior wall, an inner wall that defines an inside perimeter of the container, and a bridge piece connected between the exterior wall and the inner wall such that a reservoir space is formed between the exterior wall and the inner wall. The inside perimeter of the container provides a containment space within the container that is sized to contain the tube and the anal probe. An opening is formed in the container and communicates with the reservoir space. The reservoir space is configured to contain irrigation liquid. The displaceable pump element is located in the reservoir space, where the displaceable pump element is adapted to increase pressure in the irrigation liquid.

Abstract: A method for collecting and filtering biological material from blood and other fluids during a surgical procedure includes: attaching a first cover including a suction port and an intake port to a collection trap; attaching a suction source to the suction port; attaching an instrument to the intake port, through which blood and tissue are suctioned and received into the collection trap; filing the collection trap with blood and tissue; removing the collection trap from the first cover; attaching a second cover to the collection trap in place of the first cover, the second cover including a suction port and a plunger, the plunger including a press head having a screen portion permitting blood and other fluids to pass; attaching a suction source to the suction port of the second cover; separating the blood from the tissue by deploying the plunger; and drawing off the blood through the suction port.

Abstract: Various devices and methods for filtering and/or collecting tissue which has been cut or resected from various regions of a patient's body are described herein. In certain variations, a filter or tissue collection chamber may include various components, which allow for the removal or separation of tissue from a fluid medium and for the collection of the tissue within the filter or tissue collection chamber.

Abstract: Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.

Abstract: An apparatus and method that allow multiple samples of a liquid in a primary container (here called a ‘pouch’) to be taken with minimal danger of contaminating the liquid in the container during the sampling process are disclosed. In an embodiment, a closed sterile sight chamber is connected with the pouch in a sterile manner to allow fluid to flow into the chamber while at the same time allowing air within the chamber to be displaced through a bacterial filter to atmosphere. The connection between the sight chamber and the pouch is then terminated (severed or closed), isolating the pouch from the sampling apparatus. Only then are samples of liquid withdrawn from the sight chamber, while allowing air to flow into the chamber through the bacterial filter.

Abstract: Liquid drug transfer devices including a vented vial adapter having a top wall, a downward depending skirt, and a dual lumen puncturing spike. The top wall includes vent apertures in flow communication with an underlying air filter and protective hoods for covering the vent apertures from splashes. The hood-like hoods are preferably quarter sphere shaped with hood apertures facing radial outwards.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices with a pressure oscillation mechanism. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.

Abstract: The present invention relates to a container for anal irrigation. In particular it relates to a rigid container which is easy to operate and which easily is transformed from a storage configuration to a ready-to-use configuration. In one aspect the invention relates to a container for an anal irrigation system. The anal irrigation system comprises an anal probe; a reservoir for holding an irrigation liquid (e.g. water); a pump mechanism for pumping a fluid (e.g. air) into the reservoir; and a liquid tube connecting the reservoir with the anal probe. The container comprises an outer chamber wall, defining at least partly the outer dimensions of the container and an inner chamber wall arranged within the outer chamber wall, said outer chamber wall and inner chamber wall defining the reservoir. This provides a reservoir having a small surface area when filled with irrigation liquid. Thus only a low pressure is necessary to evacuate the irrigation liquid from the reservoir and out through the anal probe.

Abstract: A container for use in dialysis, containing a certain amount of a salt concentrate in the form of a powder, granules or tablets or mixtures thereof, having an inlet for the water and an outlet that is connectable to a dialysis machine. Both the inlet and the outlet are situated on one side of the container, and each includes a filter therein to prevent any undissolved salt concentrate from leaving the container.

Abstract: An apparatus for removal of premixed drugs or reconstitution of lyophilized drugs and for the injection of the reconstituted drug into the patient. The apparatus includes a syringe assembly and an adapter assembly that can be removably connected to a medicament container containing a premixed drug or lyophilized medicament. The syringe assembly of the apparatus includes a liquid chamber between the forward end of the body portion and the piston and a syringe cannula assembly. The syringe cannula assembly, which can be removably interconnected with the body portion, comprises a cannula support and a hypodermic needle sealably connected to the cannula support. The adapter assembly comprises an adapter preferably molded from a moldable plastic that includes a top wall, an adapter cannula connected to and extending from the top wall and a variety of connectors connected to the top wall for removably interconnecting the adapter with the medicament container.

Abstract: A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation.

Abstract: An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed.

Abstract: The present invention relates to a bag (1) for packaging a biological substance, such as animal semen, which is formed by two plastic walls (10, 11) assembled so as to define a pouch (P) for receiving said substance and that comprises a line (15) communicating with said pouch (P) a line for filling the same, this bag comprising in addition at least one pair of openings (3, 4) located on both sides of said line (15), in order to get hung, via these openings, to fingers that are complementary to a supporting device. This bag is characterized in that at least one of these openings (3, 4) has an oblong shape, extends perpendicularly to said line (15), and comprises an area forming a hard spot. The invention relates also to a strip formed by juxtaposing such bags (1), and an assembly comprised of a bag and a hanging support.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Current filters are inefficient at removing small bubbles that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter.

Abstract: A vial adaptor configured to be attached to a wide range of vial sizes, the adaptor being configured to penetrate the vial seal so that the contents of a vial can be removed. The vial adaptor can have a body portion, a penetrating portion projecting from the body portion and configured to be inserted through the seal and positioned within an interior space of the vial so that the contents of the vial can flow through an opening in the penetrating portion, an interface portion supported by the body portion that is connectable to a syringe or other medical implement, at least one deflectable tab configured be bendable by hand or to bend in response to contact with the vial. The vial can also have a filtered air vent to allow air to fill the vial as the contents thereof are being removed.

Abstract: In a blood bag system mounted in a centrifugation and separation apparatus, a filter is settable in different appropriate orientations at storage time and usage time, and first and second tubes and a filter are arranged respectively in appropriate orientations during use. The blood bag system includes a BC pooling bag for centrifugation of buffy coat, the filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, the first tube connecting the BC pooling bag and an inlet of the filter, the second tube connecting the platelet preserving bag and an outlet of the filter, a cassette fixable in the centrifugation and separation apparatus, an attachment for holding the filter, and a hinge section tiltable relative to the cassette with reference to an axis in the circumferential direction.

Abstract: A wound-closing dressing, which is suitable for use as part of a reduced-pressure, wound-treatment system, may include a sealing drape, one or more contracting elements, and a gripping member. The contracting element may be coupled to the sealing drape and is configured to contract when activated and to generate a closing force. A gripping member is coupled to the sealing drape and is configured to transmit the closing force to a patient's epidermis. Other dressings, systems, and methods are also disclosed.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).

Abstract: Described is a collapsible fluid reservoir that may be expanded during use and collapsible to lie substantially flat when not in use. According to one embodiment, a collapsible fluid reservoir can include a substantially non-rigid container having a substantially open proximal end and a substantially sealed distal end opposite the proximal end defining a cavity therein, wherein the distal end includes at least one fluid outlet port extending therethrough. The collapsible fluid reservoir can also include a substantially rigid cap affixed to the proximal end of the non-rigid container and including at least one fluid inlet port extending therethrough and in fluid communication with the cavity.

Abstract: A method for retaining aerosols when accessing a sealed vial is disclosed. The method includes the steps of piercing the vial seal with a sharp cannula having a medicament lumen and a vent lumen, introducing a liquid through the medicament lumen into the vial, and conducting gas out of the vial through the vent lumen and a vent port to the atmosphere. The method also includes the steps of blocking the passage of non-dispersed liquid out the vent lumen at a first filter device comprising pores having a diameter in the range of 0.2-3.0 microns, absorbing liquid dispersed in gas at a second filter device, and inhibiting the passage of bacteria at a third filter device having a pore size smaller than 0.2 microns.

Abstract: A collecting device for fluids for medical use may include a rigid container internally defining a first chamber having a fixed volume, an auxiliary container having a deformable portion defining internally thereof a second chamber having a variable volume as a function of a deformable portion thereof, a passage able to set the first and the second chamber in fluid communication, an inlet port connected to at least one of the containers, and an outlet port connected to at least one of the containers, as well as a bypass line for bypassing the device.

Abstract: An ampoule made of plastics material, for liquid or suspension pharmaceuticals, has a reservoir linked to a removable head by a channel in a neck portion. The channel has a trap, thus located between its reservoir and the head, in the form of an elongated restriction and/or a bend to trap liquid or suspension which may settle during storage, and prevent either reaching the head.

Abstract: A biological fluid filtration device, system, and method, for filtering a biological fluid, the device comprising a housing having an inlet, a first outlet and a second outlet, with a first fluid flow path defined between the inlet and the first outlet, with a second fluid flow path defined between the inlet and the second outlet, with a first biological fluid filtration media interposed between the inlet and the first outlet and across the first fluid flow path, with a second biological fluid filtration media interposed between the inlet and the second outlet and across the second fluid flow path, the housing essentially lacking a solid partition wall between the first biological fluid filtration media and the second biological fluid filtration media, a first flow restriction may be added downstream of the first biological fluid filtration media, and a second flow restriction may be added downstream of the second biological fluid filtration media, in another embodiment, the device comprises a housing having

Abstract: This invention relates to medical devices for labelling a syringe filled from an ampoule, and to safer devices for filling a syringe from an ampoule, and to associated methods. We describe a device for attaching to an ampoule to label a syringe filled from the ampoule, the device comprising: an ampoule-mounting portion for mounting the device to a filled ampoule; a syringe-fitting portion to enable the device to be fitted onto said syringe; and a label holder to hold a label for contents of said ampoule; and wherein one of said syringe and said ampoule is detachable from said device; and wherein said label is configured such that in conjunction with a filling operation of said syringe and detachment of said one of said syringe and said ampoule from said device said syringe is labelled by said label.

Abstract: A blood bag system includes: a first bag in which blood containing multiple components is stored; a second bag in which a relative medium-density component is stored; a third bag in which a relative low-density component is stored; a first tube through which the relative low-density component and the relative medium-density component are transported from the first bag to the second bag; and a second tube through which the relative low-density component is transported from the first bag to the third bag. A blood treatment method involves: centrifuging blood containing multiple components in a first bag, transporting a low-density component from the first bag to a third bag through a first tube and transporting a relative medium-density component from the first bag to the second bag through the first tube.

Abstract: An ampoule made of plasties material, for liquid or suspension pharmaceuticals, has a reservoir linked to a removable head by a channel in a neck portion. The channel has a trap, thus located between its reservoir and the head, in the form of an elongated restriction and/or a bend to trap liquid or suspension which may settle during storage, and prevent either reaching the head.