Abstract: A tubular set for the conveyance of blood includes flexible set tubing and a bubble trap chamber connected to the tubing for any desired extracorporeal blood transport process. The bubble trap chamber includes a housing defining an outer wall, a flow inlet to the interior of the housing, and a flow outlet at or near the bottom of the housing. The housing also includes an inner wall adjacent to its top. The inner wall is radially inwardly spaced from the outer wall within the chamber, extending circumferentially and generally parallel to the outer wall for at least about 90.degree. of the circumference of the outer wall and preferably at least 180.degree., to define a circumferential passageway between the inner and outer walls. The flow inlet communicates with the circumferential passageway, so that blood can be directed to flow from the inlet horizontally and circumferentially through the passageway to a pair of passageway outlets.

Abstract: The invention resides in apparatus and methods for isolating and collecting cells from donor tissue for later use in medical procedures. The apparatus includes a sealed enclosure, at least one screening material inside the enclosure, an inlet port configured to conduct a fluid through the screening material, and an outlet port for receiving the fluid from the screening material and conducting the fluid out of the enclosure. A material to be screened is placed inside or conducted into the enclosure. Screened material is entrained in the fluid. The fluid carries bits of the material through the screening material and out of the enclosure for later separation from the fluid. Preferred embodiments include a series of screening materials of decreasing pore size, usually in the range from ten to one thousand micrometers in diameter.

Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

Abstract: The invention resides in apparatus and methods for isolating and collecting cells from donor tissue for later use in medical procedures. The apparatus includes a sealed enclosure, at least one screening material inside the enclosure, an inlet port configured to conduct a fluid through the screening material, and an outlet port for receiving the fluid from the screening material and conducting the fluid out of the enclosure. A material to be screened is placed inside or conducted into the enclosure. Screened material is entrained in the fluid. The fluid carries bits of the material through the screening material and out of the enclosure for later separation from the fluid. Preferred embodiments include a series of screening materials of decreasing pore size, usually in the range from ten to one thousand micrometers in diameter.

Abstract: A blood reservoir for the treatment and collection of blood from two different sources. The blood reservoir has a filter/defoamer core assembly comprised of a support structure disposed within an outer defoamer. A separator with an opening is located in the support structure, dividing the support structure into a first and second portions. A depth filter is located within the first portion of the support structure. The first portion of the support structure with the depth filter forms a cardiotomy blood chamber and the second portion with no depth filter forms a venous blood chamber. This filter/defoamer core assembly is placed within a clear outer shell which forms the reservoir. This outer shell has a cover with a venous blood inlet and plurality of cardiotomy inlets. The cardiotomy inlets are in fluid communication with the cardiotomy blood chamber.

Abstract: A device for separating gas bubbles out of medical fluids, in particular blood, has a substantially cylindrical chamber, an inlet connection arranged in the longitudinal direction of the chamber, an outlet connection and a flow-guide member attached to the inlet connection and having a plurality of flow channels, which extend in a space curve out of the longitudinal direction of the chamber in a direction running substantially tangential to the inner wall of the chamber. An orifice, which is sealed by a hydrophobic membrane, is provided in the cover part of the chamber. Since the outlet orifices of the flow channels are arranged directly underneath the cover part, the membrane is circumflowed by the inflowing fluid, avoiding the formation of dead zones. The device makes it possible to separate out air bubbles with a substantial degree of reliability, without the danger of the hydrophobic membrane becoming obstructed from contact with the blood.

Abstract: An intravenous filter device comprises a filter housing having a front side, a back side, a first end, a second end, an inlet and an outlet, the housing containing a hydrophilic filtration media and defining a flow path such that intravenous fluid entering the housing through the inlet passes through the filtration media before passing out of the housing through the outlet. Inlet and outlet tubing connectors, both preferably attached to the front side of the filter housing, form, respectively, the housing inlet and outlet. In the preferred embodiment the connectors are raised above the front side or the housing such that tubing connected to the connectors does not intersect the front side of the housing. At least one vent hole in the housing provides a passageway for gas to escape from the housing, the vent hole being preferably open to the front side of the housing.

Abstract: The disposable flexible pouch for collecting and filtering blood has two inner chambers separated from each other by a filtering screen (11), a first chamber being connected to the outside by an outlet opening for the filtered blood and a second chamber being connected to the outside by an inlet opening for the blood to be processed. The pouch is formed from two superposed walls (1, 2) made of a flexible plastic material and bonded together by welding of their respective peripheral edges (3). The inlet and the outlet openings for the blood, as well as an outlet opening (5) for the suction air provided with a bacterial filter, are all made in the same wall (2) forming the pouch and the filtering screen (11) having a lower surface at the surface of this same wall (2) cooperates with the inner face thereof to form several compartments communicating with one another and forming the second chamber, so that the retention volume is reduced.

Abstract: A vacuum filter device is disclosed which includes a filter body which is adapted to receive in fluid-tight, sealed relationship a pair of closed containers for solutions to be filtered by a membrane filter positioned within the filter body. A vacuum port in the filter body communicates with the downstream side of the membrane and a venting passageway also located in the filter body communicates with the closed sample container to serve as a vent to atmospheric pressure. The venting passageway is made of an air permeable hydrophobic filter or preferably a small enough opening to prevent the sample solutions from leaking out of the device during normal use.

Abstract: For an apparatus for the extra-corporal treatment of blood wherein blood is supplied from a body to a vacuum bottle via a conduit, an insertion spike for piercing a closure plug of a vacuum bottle has a front end with a pointed tip and includes a first passage extending from the front end to a connecting piece for connection to a gas supply means, the front end having a perforated side wall for the diffused discharge of gases admitted through the first passage and a second passage having means for connection to a blood conduit and extending to an opening in the side of the insertion spike adjacent the perforated side wall.

Abstract: A disposable, flexible plastic filter pouch includes a top inlet opening for collection of blood, urine or other body fluids; a filter sheet for collecting and retaining solid materials such as kidney stones which may be contained in the fluids; and means for sealing the pouch after use to enable the solid sample collected to be sent to a laboratory for analysis with no need to place the solid material in another container and minimum exposure of hospital personnel to the sample.

Abstract: An integral blood oxygenator and heat exchanger device for oxygenating and heating or cooling a patient's blood during heart bypass surgery. The device preferably includes a pleated blood filter disposed within a gap formed between the opposite ends of the blood oxygenating medium. A blood inlet manifold closely receives a tubular heat exchanging barrier and directs blood flow around the barrier to a blood outlet slot. The blood oxygenating medium covers the blood outlet slot so that blood must flow through the blood oxygenating medium before reaching the blood filter. A vent port and bypass port may be provided in the gap formed by the opposite ends of the blood oxygenating medium upstream of the blood filter.

Abstract: A fluid delivery apparatus which includes a fluid delivery assembly and a unique fill assembly that can be used to controllably fill the fluid reservoir of the fluid delivery assembly in the field. The fill assembly includes a fluid containing vial assembly mounted within a unique adapter assembly which functions to conveniently mate the vial assembly with several different types of fluid delivery assemblies of the character that embody self-contained stored energy means.

Abstract: A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening.

Abstract: A device (10) for receiving, storing, filtering and reinfusing a patient's blood is described. The device is a flexible container that has two unique features in the preferred embodiment. One feature is the use of a filter (24) which filters blood immediately prior to reinfusing blood into a patient. The other feature is the use of a separating means (32) to prevent the filter from collapsing upon itself.

Abstract: An instillator having a medicator-connecting mouth into which a medication that cannot be subjected to sterilization may be introduced by a simple operation and in a germ-free condition so that the medication is mixed with a pharmaceutical liquid contained therein, said instillator being composed of an outlet member, a medicator-connecting mouth and a body, said medicator-connecting mouth comprising a communicating pathway which communicates with the inside of the body upon use, a germ-trapping filter disposed in the middle of said communicating pathway, a sealing means for sealing said communicating pathway disposed between said germ-trapping filter and said body, and a connecting means disposed at one end of said communicating pathway opposite to the body, the body made of a flexible material being filled with a pharmaceutical liquid, sealed and subjected to autoclaved sterilization, the connecting port of the instillator having a connecting duct tightly fitted into the port.

Abstract: A fluid filtering device for separating liquid from gases to be analyzed, including a tubular housing defining a space therein and having inlet and outlet end portions delimiting passageways in fluid communication with the space, the portions being connectable between a source of fluid and a gas analyzer, and a liquid/gas hydrophobic hollow fiber filter element located within the tubular housing preventing material other than gases to pass therethrough. The tubular housing and filter element form a small volume within the housing, and the device is effectively operable independent of its orientation, or field of gravitation acting thereon.

Abstract: An HME has an exchange element comprising a bundle of hollow fibers parallel to the direction of gas flow through the HME. The fibers are of a polymeric material, such as a sulphone, and are treated with a hygroscopic material. The bundle of fibers is held together by an outer sleeve and a porous cap at each end.

Abstract: A filter assembly for elective use in conjunction with a surgical evacuation system is provided which includes a filter housing having a head portion and a body portion with a through passageway extending therebetween defining a filter receiving chamber. The head portion is connectable to an aspirator tip and the body portion is connectable to a flexible suction conduit. A filter element is disposed within the filter receiving chamber of the filter housing. The filter element includes a head member having a fluid flow passageway extending therethrough, a fluid impermeable base member spatially disposed from the head member and a fluid permeable body member disposed between the head member and the base member.

Abstract: A link for use between a needleless syringe and a liquid medicine vial may be used equally well with both Luer lock and slip tip syringes. An adapter flange forms both an anchor for a conventional Luer lock and a receiving receptacle for a conventional slip tip syringe. The bottom end of the receiving receptacle is capped with a cylindrical sieve providing multiple fluid flow paths. The vial end of the link is formed with a pocket for collecting fluid when the vial is inverted. Two separate versions are provided, with one having a flip-top cap flush with the top of the medicine vial and the other having a twist-off top extending above the top of the vial. An outer jacket, surrounding the vial top is an optional variation on either version and provides for resealing of multiple dose vials. A valve automatically seals the vial to protect against loss of fluid and contamination of remaining fluid within the vial, in the event that the vial is overturned.

Abstract: A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.

Abstract: A vacuum filter device is disclosed which includes a filter body which is adapted to receive in fluid-fight, sealed relationship a pair of closed containers for solutions to be filtered by a membrane filter positioned within the filter body. A vacuum port in the filter body communicates with the downstream side of the membrane and a venting passageway also located in the filter body communicates with the closed sample container to serve as a vent to atmospheric pressure. The venting passageway is made of an air permeable hydrophobic filter or preferably a small enough opening to prevent the sample solutions from leaking out of the device during normal use.

Abstract: Methods and apparatuses for removing unwanted fluid such as gas from a processed blood product are disclosed. Methods include the steps of passing a blood product from a closed first container through a functional biomedical device to produce a processed blood product, flowing the processed blood product and an unwanted fluid from the functional biomedical device to a second container through a conduit, separating the unwanted fluid from the processed blood product in the second container, preventing the flow of the unwanted fluid from the second container through the passage to the functional biomedical device by using a clamp and passing the unwanted fluid from the second container to the first container through an outlet providing fluid communication between the second container and the first container. The outlet includes a barrier medium which allows the passage therethrough of the unwanted fluid but prevents the passage therethrough of the processed blood product.

Abstract: A method for preparing platelets comprises the steps of obtaining whole blood from human, preparing platelet rich plasma from the whole blood and then passing the platelet rich plasma through a filter comprising a porous medium having a CWST of at least about 70 dynes/cm, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from human.

Abstract: An improved blood reservoir formed by opposed, flexible sheets has a screen sandwiched between the sheets defining an input chamber, an output chamber, and vent chamber. A vent is in fluid communication with the vent chamber. An outlet is in fluid communication with the output chamber. One or more inlets direct blood into the input chamber through apertures that direct blood upward and along the screen, allowing gas bubbles entrained in the blood to escape through the vent. Support springs around the inlets allow them to be flexed without kinking. The reservoir can be coupled to an improved mounting board for use.

Abstract: A soft shell reservoir bag is provided as a storage reservoir for blood in a bypass extracorporeal circuit during open heart surgery. The reservoir bag is constructed to allow for the easy venting of air and to prevent the accidental delivery of air to patient. Blood enters the reservoir through the inlet port, passes through the microscreen and exits through the outlet port to a pump which feeds an oxygenator. The shape of the bag and component disposition give the bag its main advantages. The inlet port is positioned above the outlet port which puts a larger volume above the outlet port which promotes mixing and no vortex. Also the shape above the outlet port gives the bag a low hold-up volume and lower resistance to keep the bag open. The shape also promotes low venous resistance.

Abstract: This invention relates to a new and improved design associated with the fabrication and construction of a needleless transfer system wherein through the use of a unique valve mechanism there is avoided the necessity to utilize a needle in conjunction with a syringe for purposes of transferring and/or injecting a liquid medium from one environment into another environment. By having the valve mechanism comprise a hollow enclosure which has contained therein a compressible structure which acts both as a filter and as a mechanism to allow for the selective flow of a liquid medium through the system in a singular direction, the capabilities of the needleless transfer system are achieved.

Abstract: A fluid container assembly which can be aseptically filled in the field with selected fluids and one which is specially designed for sterile coupling and use with fluid dispensing and delivery devices of the character that embody stored energy sources such as compressible cellular masses and distendible elastomeric membranes that form, in conjunction with a cooperating base, fluid chambers for containing the fluid to be dispensed.

Abstract: Disclosed is a method for separating a blood material into blood components by centrifugation, wherein when a multiple blood bag unit including a plurality of flexible blood bags (at least one of the flexible blood bags containing a blood material) liquid-tightly connected to at least one leukocyte-removing filter device through flexible tubes in a predetermined order is accommodated in a centrifuge bucket, at least the blood material-containing flexible blood bag or bags are inserted in the centrifuge bucket while placing at least the leukocyte-removing filter device outside of the centrifuge bucket, wherein the leukocyte-removing filter device is directly or indirectly secured relative to the rotor and a center of the filter device is located at a distance from an axis of the rotation shaft which is smaller than a distance between a pivotal axis of the turning of the centrifuge bucket and an axis of the rotation shaft at a portion thereof which has the rotor connected thereto.

Abstract: Disclosed is a leukocyte-removing filter device comprising (a) a casing having an inlet for blood and an outlet for leukocyte-removed blood, which are both located in a top portion of the casing, and (b) a filter medium disposed in the casing so as to divide the internal space of the casing into an inlet-side chamber communicated with the inlet and an outlet-side chamber communicated the outlet.

Abstract: A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.

Abstract: A blood processing method provides a red blood cell product that is free of microorganisms like Yersinia enterocolitica during storage periods over 24 hours. The red blood cell product is collected in a first container, where it is refrigerating to cool the blood product to a temperature of about 3 to 5 degrees C. The refrigerated product is transferred from the first container into a storage container through a prescribed filter medium that comprises a mass of synthetic fibers having an average fiber diameter of about 10 microns or less and a bulk density of about 0.7 gram per cubic centimeter or less. The filtered product is retained in the storage container at a temperature of about 3 to 5 degrees C. for a storage period over 24 hours after filtration. Using the filter medium, microorganisms like Yersinia enterocolitica present in the red blood cell product at the time of collection are depleted.

Abstract: A liquid dispenser for dispensing sterile liquid comprising a container for storing the sterile liquid, a nozzle assembly mounted on the container, and a filter which has at least one surface and a plurality of its pores coated with a metallic material, e.g., a metal or metal oxide or metal salt, that is bacteriostatic or bacteriocidal, is described. The metal coated filter, methods for coating the filter, and methods for using the liquid dispenser are also provided.

Abstract: A liquid filtration device useable for removing leukocytes from blood contains a first chamber which is in fluid flow relationship with a second chamber. Filtration elements separate the first chamber from the second chamber so that liquid flowing from the first chamber is filtered thereby prior to entry into the second chamber. A passage leads from the second chamber into the first chamber and a hydrophobic filter may be used to prevent liquid from the first chamber from flowing through the passage into the second chamber while allowing air to flow therethrough. An outlet is located in the second chamber, preferably at the bottom thereof. A second outlet may be located within the second chamber and may be placed in fluid flow relationship therewith by a conduit or the like.

Abstract: The present invention is directed toward a cytology collection apparatus and a method for preparing a uniform monolayer of cells. The apparatus allows the rapid preparation from body fluids of a cytology monolayer with very few overlapping cells and with fewer contaminants than prior devices. The apparatus is in the form of an openable cell collection container which houses a filter for collection of cells when body fluid passes therethrough.

Abstract: Disclosed is a method for separating a blood material into leukocyte-removed blood component products, which comprises providing a multiple blood bag system comprising a primary bag containing a blood material, a leukocyte-removing filter device comprising a flat casing, and at least one satellite bag, and centrifuging the blood material using a centrifuge cup having the multiple blood bag system accommodated therein, to thereby separate the blood material into blood components, wherein the centrifugation is performed with the filter device being held by a filter device holder having a substantially flat dimension which is disposed in a centrifuge cup so as to extend in a direction perpendicular to an inner bottom floor of the centrifuge cup, and wherein the filter device holder has a recess and the filter device is received by the recess in a manner such that a flat surface of the flat casing of the filter device is perpendicular to the inner bottom floor of the centrifuge cup.

Abstract: A link for use between a needleless syringe and a liquid medicine vial may be used equally well with both Luer lock and slip tip syringes. An adapter flange forms both an anchor for a conventional Luer lock and a receiving receptacle for a conventional slip tip syringe. The bottom end of the receiving receptacle is capped with a cylindrical sieve providing multiple fluid flow paths. The vial end of the link is formed with a pocket for collecting fluid when the vial is inverted. Two separate versions are provided, with one having a flip-top cap flush with the top of the medicine vial and the other having a twist-off top extending above the top of the vial. An outer jacket, surrounding the vial top is an optional variation on either version and provides for resealing of multiple dose vials.

Abstract: Stoppers for medicine vessels are disclosed. Such stoppers comprise an insert having one end frictionally engageable within an opening in a medicine vessel. Such inserts' other ends have a fitting, e.g. a luer complimentary with a luer on an opening in the medicine vessel. The fitting allows the contents of the medicine vessel to be withdrawn without using a sharp object, such as a needle.

Abstract: A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.

Abstract: A self-priming filter holder for filtration of intravenous liquids is provided and is formed of one or two housing portions sealed to a core portion. The core portion has one or two ribbed surfaces forming a plurality of flow paths sealed at one end and open at a second end and at least one channel preferably larger than the flow paths. The channel(s) is in fluid communication with the flow paths and an outlet. An inlet is provided to the interior of the housing portion(s) which are sealed from the ribbed surfaces by hydrophilic membranes. The housing portion(s) can be provided with gas vents sealed with hydrophobic membranes. Fluids pass through the flow paths in one direction and through the channel(s) in an opposite direction to remove gas from the flow paths and channels prior to use.

Abstract: An irrigation set for use with a laparoscopic and/or hysteroscopic irrigation pump includes a bottle cap having an open mouth, closed-end cup shape threaded on the inside surface and defining a region just inside the closed end provided with an undercut and an opening defined in the closed end. A disk assembly is composed of a disk received in the region and retained therein by the undercut. The side of said disk inside the cap defines a depending skirt. The disk defines a first opening aligned with the depending skirt, a check valve cartridge and draw tube secured to the depending skirt. A first tubular projection on the disk is aligned with the first opening and projects through the opening in the closed end. A second tubular projection on the disk is aligned with the second opening and projects through the tubular opening in the closed end. A gas tubing is secured at one end to the second tubular projection, and a gas fitting is secured to the other end of the gas tubing.

Abstract: A burette top vent which resists air blockage includes a peripherally skirted cap having a generally planar circular base transfixed by a short integral tube having an upper portion to which tubing from a source of fluid may be attached and a lower portion from which fluid can drip into the burette. The base is perforated by an array of arcuate slots that permit air to enter the burette, and the bottom surface of the base has a shallow annular relief intersecting the slots. A ring-shaped hydrophobic filter disk hermetically affixed beneath the relief. The relief prevents the filter disk from lying flush against the bottom surface of the base.

Abstract: An apparatus for handling a patient's blood during a first medical use which is convertible for a second medical use comprises a first device, for adapting the reservoir for use during a first medical use and a second device for adapting the reservoir for a second medical use after the first medical use. A lever pivotally mounted on the apparatus, engages at least one of the devices so that pivoting the lever causes the devices to move, moving the first device out of its operative position and moving the second device into its operative position. A lock for the lever locks the devices in place, and a valve mechanism automatically selects a proper outlet.

Abstract: A method of preparing platelets for long term storage comprises the steps of (a) obtaining whole blood from a human, (b) preparing platelet rich plasma from the whole blood and (c) then passing the platelet rich plasma through a filter under conditions sufficient to remove substantially all leucocytes from the plasma, with steps (b) and (c) occurring in an integrally attached blood bag system within a few hours of step (a).

Abstract: Apparatus for blood collection includes a collection bag with a suction inlet, a fluid inlet, and an outlet, and an internal stent that resiliently biases the bag into a fixed shape while moving to modulate abrupt variations in suction level. A gross filter about the outlet is located out of the suction path, eliminating blood damage from drying or cell trauma. Different graduation scales show the true volume of collected fluid under suction conditions during collection and with no suction during reinfusion. Two quick-connects allow in-line connection with a chest drain to provide suction, and mate with each other to close the inlets when the filtered bag is removed for gravity reinfusion. When multiple units are piggy-backed, they fill sequentially and may be removed for reinfusion quickly, with only a single tube reconnection required during surgery.

Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely contolled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.

Abstract: A container for quick connection and disconnection to a dialysis generator, the container having a substantial amount of solid compound for extemporaneous and continuous preparation of dialysate obtained from dissolution of a concentrate and/or from the solid compound in treated water. A conduit leads the water from an inlet orifice to the container, where the treated water passes through the solid compound and therethrough to and outlet orifice and into the dialysis generator. The water may be directed through a conduit within the container or through a conduit outside the container. The inlet and the outlet orifices may be provided with a micron filter.

Abstract: A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.

Abstract: The present invention provides an improved method and container for filtering a body fluid. The method comprises the steps of isolating a volume of solution in a first chamber of a container; collecting a body fluid in a second chamber of a container; passing the body fluid through a filter; and rinsing the filter with an isolated volume of solution.

Abstract: Systems and methods of collecting blood cells, substantially free of undesired matter, use a first container, that forms a part of a blood collection system, to initially collect a quantity of blood cells. A filtration system is then attached to the first container. The filtration system includes a second container, a first fluid path that leads to the second container through a filtration device, and a second fluid path that leads to the second container bypassing the filtration device. The blood cells are conveyed from the first container through the first fluid path and filtration device and into the second container to separate the undesired matter from the blood cells. The blood cells, now substantially free of the undesired matter, are then conveyed from the second container through the second fluid path, bypassing the filtration device, and back into the first container. The filtration system is then detached from the blood collection system.