Abstract: Foil bags are used as a primary packaging for liquids, the bags permitting the liquid to be taken therefrom without the application of a considerable amount of force. A container is provided for a medicinal liquid, the container being gas-tight and liquid-tight so that it is storable over many months. The container includes a collapsible foil bag on which a flange, which is stable in respect of shape, is disposed. The flange is designed for fitting onto a discharge connection member. The container can be disposed in a casing which is stable in respect of shape. The medicinal liquid does not come into contact with air and is protected from the effect of light. The medicinal liquid may be dispensed from the foil bag in many partial quantities over a prolonged period of time, with a respective partial amount thereof being converted into an aerosol by means of an atomizer.

Abstract: Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form.

Abstract: A connector for connecting a container with a fluid preparation device for preparing a fluid, in particular a container with a concentrate for the preparation of dialysis fluid, as well as the combination of the connector, the corresponding container and the fluid preparation device. In order to simplify the handling during both the manufacturing process of such containers and the connection of such containers to the fluid preparation devices, the connector connects a first and second fluid line of the container with a third and fourth fluid line of the fluid preparation device with two laterally spaced-apart mounting elements which each incorporate one of two orifices terminating the first and second fluid lines.

Abstract: An RF sealable composition and film is provided in which the composition and film includes a blend of an ethylene/alpha-olefin and an ethylene acrylate copolymer. The composition and resulting film has a dielectric loss factor of at least 0.02 and is capable of being radio frequency sealed. Films in accordance with the invention provide RF seals having peel strengths on the order of 500 g/in or greater. In a further aspect, a film is provided having at least one exterior layers that comprises a blend of an ethylene/alpha-olefin copolymer and an ethylene acrylate copolymer. Suitable ethylene acrylate copolymers for use in the invention include of ethylene vinyl acetate (EVA), ethylene butyl acrylate (EBA), and ethylene methyl acrylate (EMA).

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.

Abstract: An object of the present device is to provide a cover capable of preventing the administration of unmixed medicaments to a patient. The cover for being mounted on a multi-compartment infusion bag of the present device is a cover for being mounted on a multi-compartment infusion bag including a plurality of compartments partitioned by at least one easily peelable partitioning seal portion which is opened in response to an increase in the internal pressure of at least one of the plurality of compartments induced by pressing said at least one of the plurality of compartments. The cover has a pair of pinch members that pinch at least one of the plurality compartments. The pair of pinch members has engaging elements that engage each other to maintain a pinching state of the pair of pinch members until the pinching state is released in response to an increase in the internal pressure of said at least one of the compartments so that the suspension portion can be used.

Abstract: The present invention relates to a multi-chamber medical bag, which is capable of obtaining a positive mixture of medicines, prior to the discharge thereof. A weak seal 24 is provided for dividing the space inside the medical bag 10 into the left-handed and right-handed partitions 26-1 and 26-2. The weak seal 24 has a first portion 24-1 extending between the partitions 26-1 and 26-2 and a bifurcated adjacent to and faced with an outlet port 12. Additional strong seals 30-1 and 30-2 are arranged on both sides of the second portion 24-2 and extend at right angle to the first portion 241 toward the strong seal 14 at the outer periphery of the medical bag. When the partition 26-1 or 26-2 is pressed, the resultant inflated deformation of the medical bag is mainly directed to the first portion 24-1 due to the existence of the additional strong seals 30-1 and 30-2, which allows the last portion to be separated, resulting in a mixing of the medicines in the partitions 26-1 and 26-2.

Abstract: Apparatus for reducing the fat content of blood and in particular to an apparatus for reducing the fat content of pericardial suction blood has a conduit for blood, an absorbing filter located in the conduit and an associated temperature control device for adjusting the temperature of blood before it flows through the filter.

Abstract: The present invention provides an improved kit for the collection of umbilical cord blood and placental blood, and collection of the placenta from which such blood is obtained. The kit improves upon existing kits in that it provides for improved user convenience, provides for the collection of the placenta itself, and better maintains the internal temperature of the container in which the collected blood and placenta are shipped to a blood bank or registry. The invention further provides a method of collecting umbilical cord and placental blood, and the placenta from which such blood is obtained, comprising using the kit described herein.

Abstract: The invention relates to a sealed, sterile system for filtering fluids, in particular whole blood. The system comprises a first collapsible container for receiving the fluid to be filtered and a second collapsible container for receiving the filtered fluid, both containers interconnected by a fluid line, in which a filter and a third container, for deaeration, are located. The first collapsible container contains a predetermined quantity of air, which is sufficient to ensure that no blood remains in the filter and the adjacent tube line sections when the whole blood is transferred from the first container into the second container. The air that is present in the second container, after the whole blood has been filtered, is transferred to the deaeration container.

Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.

Abstract: An economical yet effective apparatus and associated method heats and pressurizes a fluid-filled bag of the type used in a surgical setting. The apparatus includes an inner sealed flexible jacket including a sodium acetate solution and activator button therein operative to heat the fluid-filled bag. An outer sealed flexible jacket adjacent to the inner jacket includes a gas inlet for inflation thereof thereby applying pressure to the fluid-filled bag through the heated inner jacket during use.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base having an outlet opening that is initially occluded by a membrane. A pivot is disposed within the base and has a cutting surface disposed within the base, the cutting surface rupturing the membrane at least in part as the pivot is pivoted about an axis between first and second positions. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by the port assembly.

Abstract: The invention relates to a process for producing polyethylene aseptic squeezable pouches. The invention also covers said pouches and their use for medical packaging applications.

Abstract: Methods for making an using convenience kits for hazardous drug (liquid) transfer from vials to syringes and target IV connectors. The following methods for making and using are disclosed: (1) Using a conventional plastic bag as a vial and vial adapter enclosing shroud. (2) Using of a flange (i.e. latch arm) free vial adapter which may, therefore, be used for a large variety of vial sizes. (3) Providing a seal about an access hole through which a vial adapter dispensing portion provides a closed fluid dispensing pathway. (4) Using the shrouding bag and an associated elastic band to provide desired stability of a spiked vial. (5) Accessing, measuring and transferring vial contents directly from a vial to a target IV container.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A flexible multi-chamber container for preparation of medical mixed solutions includes at least three chambers separated from each other by leaktight seams. The chambers are designated to be filled with different solutions and are separated from each other by leaktight seams. At least a part of the first leaktight seam is provided with a separation zone to be opened for fluid transfer from the first chamber into the second chamber. At least a part of the second leaktight seam is provided with a separation zone to be opened for fluid transfer from the second chamber into the third chamber. The leaktight seams are arranged and the separation zones are formed such that, in use of the container for preparation of the medical mixed solution, the first separation and second separation zones are opened in a sequential order. The first zone is opened before the second separation zone is opened. Thus, the components are mixed one after another in a predetermined sequential order.

Abstract: A test for diagnostic tests, particularly for testing blood prior to a transfusion is disclosed. The test element includes at least two test units for carrying out at least two tests. The test element is provided with a fixing means for fixing the test element.

Abstract: In a peritoneal dialysis embodiment of the present invention, spent dialysate from the patient's peritoneal cavity passes, along a patient loop, through a dialyzer having a membrane that separates waste components from the spent dialysate, wherein the patient loop returns fresh dialysate to the patient's peritoneal cavity. The waste components are carried away in a second regeneration loop to a regeneration unit or sorbent cartridge, which absorbs the waste components. The regeneration unit removes undesirable components in the dialysate that were removed from the patient loop by the dialyzer, for example, excess water (ultrafiltrate or UF), toxins and metabolic wastes. Desirable components can be added to the dialysate by the system, such as glucose and electrolytes. The additives assist in maintaining the proper osmotic gradients in the patient to perform dialysis and provide the necessary compounds to the patient.

Abstract: The invention relates to a connector for medical liquid-containing packages, in particular to infusion or transfusion bags comprising a connection element (1) provided with a channel-shaped opening (1c) in which a self-sealing membrane (8) is arranged. A breakable part (17) which is connected to the connection piece closes the channel-shaped opening. Above the membrane (8), said connection element is embodied in the form a connection piece (13) comprising an internal cone (14) and external thread (15), the membrane (8) being sealed for receiving a syringe cone shaft. The inventive connector makes it possible to inject an active substance by means of a conventional Luer lock syringe devoid of an injection cannula (needle).

Abstract: A stable packaged bicarbonate solution for use in dialysis treatment and for treating anemia, iron deficiency, or reducing the required dose of recombinant erythropoietin to treat anemia includes a bicarbonate solution into which ferric pyrophosphate is dissolved. The amount of ferric pyrophosphate dissolved in the bicarbonate solution is sufficient to provide a therapeutic effect for the treatment of anemia, iron deficiency or to reduce dose of recombinant erythropoietin needed to treat anemia when the bicarbonate solution is combined with other dialysis components to form a dialysate used for dialyzing a patient. The ferric pyrophosphate is stabilized in the bicarbonate solution by holding the solution in a polyolefin container or container liner, such as a high density polyethylene container or liner.

Abstract: The disclosure relates to a connector for packaging containing medical fluids, in particular infusion or transfusion bags, including a tubular connection part for receiving a spike for the withdrawal of fluid, and having a lower opening on the packaging side and an upper opening on the connection side. A self-sealing membrane, which is pierced by the spike, is located in the connection part. The membrane has an upper, annular section leading into a lower, plate-shaped section, said annular section of the membrane surrounding the spike in a sealing manner, when the latter pierces the plate-shaped section. The membrane acts as a guide for the spike and also reseals the connector, once the spike has been removed.

Abstract: A connector for connecting a container with a fluid preparation device for preparing a fluid, in particular a container with a concentrate for the preparation of dialysis fluid, as well as the combination of the connector, the corresponding container and the fluid preparation device. In order to simplify the handling during both the manufacturing process of such containers and the connection of such containers to the fluid preparation devices, the connector connects a first and second fluid line of the container with a third and fourth fluid line of the fluid preparation device with two laterally spaced-apart mounting elements which each incorporate one of two orifices terminating the first and second fluid lines.

Abstract: The present invention relates to a method for the anticoagulation of human blood ex vivo in which blood calcium concentration remains the same, no thrombin is formed and thrombocyte function is not affected. The invention further relates to a blood coagulation factor Xa inhibitor that can be advantageously used in this method, an agent that contains an inhibitor of the blood coagulation factor Xa, and a kit for diagnosing cellular blood components. The anticoagulated blood obtained according to the invention can be used for examining cellular blood components, for example for the diagnosis of thrombocyte function.

Abstract: Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air.

Abstract: A cover for intravenous fluid bags is used to disguise the IV bag thereby reducing the level of patient fear and intimidation created by medical equipment and environments. The decorative cover can be shaped to portray a familiar object (animal, plant, vehicle), or be provided with a blank surface that can accommodate colorful stickers, drawings or removable interchangeable objects selected by the patient. The cover is comprised of an opaque front surface and an attachment means for attaching the cover to the IV bag or the IV stand. The cover is easily attached or removed by medical staff and does not obstruct the normal monitoring of fluid progress from the bag.

Abstract: The present invention relates to a packaging kit used for the stabilization of sirolimus particles wherein the packaging kit is in the form of a vacuum sealed impermeable container. It further relates to a method for stabilization of sirolimus particles as well as composition comprising the particles.

Abstract: The present invention provides a multilayer film for forming medical solution pouches that help prevent or reduce the presence of bubbles or foam in the solution after heat sterilization. In particular, the present invention provides a multilayer film for forming medical solution pouches that are capable of passing the bubble test as set forth in the Chinese State Drug Package Container Material Standard No. YBB00112005. In particular, the present invention provides a multilayer film in which polyamide 612 or calcium stearate component has been incorporated as an anti-foaming agent. The presence of polyamide 612 or calcium stearate in one or more layers of the film helps prevent the formation of foam in the solution after heat sterilization.

Abstract: A medical container (1) includes a bag-like container body (10) made up of two flexible sheets (12a, 12b). At least one of a pair of long-side sealed areas (11La, 11Lb) formed by the two sheets being bonded together is provided with a sealed protruding portion (20a, 21a, 20b, 21b) protruding toward the other long-side sealed area such that the spacing between the pair of long-side sealed areas is locally narrowed. A crease (30a, 31a, 30b, 31b) passing through the sealed protruding portion is formed in the sheets when a liquid substance has been injected into the container body in a volume greater than or equal to 10% of a defined volume of the container body and the medical container is hung. Accordingly, it is possible to know the exact amount of a liquid substance in the container by using a scale provided on the sheets constituting the container even if a crease is formed in the sheets due to the liquid substance being in the container.

Abstract: An enteral feeding device, includes a system for delivering liquid nutrients to an enteral feeding tube. The device includes: (a) a container, having first, second and third openings; (b) a tip configured to be coupled to the container, the tip having an opening in fluid communication with the first opening of the container, the second opening of the container configured such that nutrient can be delivered to the second opening and the third opening configured to receive nutrient or to allow gas expelled from the patient (e.g., through burping) to flow there through.

Abstract: Systems and methods handle air and rinsing fluid during fluid processing. The systems and methods eliminate air from a fluid processing system prior to, during, and after use. The systems and methods provide a connector assembly for establishing fluid flow from a fluid source. The connector assembly has discrete first and second passages that prevent communication between the fluid in first passage and the fluid in the second passage. Prior to system use, the connector assembly may be utilized in a priming function to remove residual air from a fluid circuit prior to use. The connector assembly may also be utilized after use to perform a rinse-back function.

Abstract: The present invention monitors an IV bag injection port and informs the user of prior injections. The present invention employs an object and/or a sealed chamber within a transparent IV fluid bag injection port. In the case of the object, notification of prior use is achieved when the object's or IV fluid's appearance is altered. With respect to the sealed chamber, the chamber's seal is breached to allow fluid to pass between the chamber and the IV bag to change the appearance of the contents of the chamber. Since the injection port and bag walls are at least partially transparent, medical personnel are able to observe the altered appearance of either the object, IV fluid or the sealed chamber.

Abstract: A blood chamber for an extracorporeal blood circuit comprises a blood inlet port (2), a blood containment chamber (3), a first conduit (8) which connects the blood inlet port (2) with the blood containment chamber (3) and which has an end tract (8a) that terminates in the blood containment chamber (3) with a horizontal inlet component. The first conduit (8) comprises a pre-terminal tract (8b) which precedes the end tract (8a) and which has at least a second horizontal component which is directed in an opposite direction to the horizontal inlet component. The blood chamber is used in an arterial line of a dialysis set for guaranteeing a regular and gentle blood flow.

Abstract: A medicine discharge stopper for a medical bag of a type where a multiple of medicines are mixed, aiming to positively exclude a possibility of generation of erroneous operation that administration is done without opening the mixing seal. The medical bag is formed from a soft film and has an inner space, which is divided into compartments 20 and 22. An outlet port 12 is provided so that it is opened to the first compartment 20. The stopper includes split halves, which, when tied, form an inner space 34 of the outlet port 12. The combination is done under a resilient force by cantilever fashioned extending parts 38. When the weak seal portion is opened, an impact-like hydraulic force is generated and the bag is widened, which causes the flaps 30 and 32 to be opened against the resilient force, resulting in a release of the stopper. The flaps 30 and 32 are made separable from the body parts, which allows the stopper to be also utilized for a holder of needle during the execution of infusion process.

Abstract: A freeze-dried material is stored in a first chamber of a container along with a reconstituting liquid for the freeze-dried material, which is stored in a second chamber of the container. A sealing wall within the container forms a barrier between the first chamber and the second chamber preventing contact between the freeze-dried material and the reconstituting liquid. At least one valve assembly in the sealing wall selectively opens a region of the sealing wall to establish fluid flow communication between the first and second chambers, allowing the freeze dried material to be reconstituted. The reconstituted freeze-dried material can be administered from the same container to a recipient.

Abstract: Fluid communication devices may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.

Abstract: A container for housing a fluid therapeutic composition includes a rigid housing, a collapsible bag and a seal. The housing has an opening and an interior surface. The interior surface forms a cavity having a volume. The bag is disposed in the housing and is expandable to contact the interior surface of the housing and occupy the entire volume of the cavity when filled with the fluid therapeutic composition. The bag has an opening that is fixed in proximity to the opening of the housing. The seal is configured to prevent air from entering the bag via the bag opening and to prevent air from entering the cavity of the housing via the housing opening.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: The present invention relates to a process of fusion-bonding a plastic film (8a, 8b) to an object to be fusion-bonded such as a port member (16) in manufacturing a drug bag, and relates to a drug bag. The present fusion-bonding process comprises steps of disposing a heat generation element generating heat by absorbing infrared laser, on an opposite surface (8c) of the plastic film (8a, 8b) from the port member (16), or between the port member (16) and the plastic film (8a, 8b), pressing a press member (30a, 30b), which allows infrared laser to be transmitted therethrough, from a side of the plastic film (8a, 8b), and irradiating the infrared laser (L) to the heat generation element (24a, 24b) through the press member (30a, 30b).

Abstract: Polymer composition comprising a thermoplastic elastomer including styrene and isoprene and/or vinylisoprene units (SI) and a syndiotactic polypropylene (s-PP).

Abstract: Provided are compositions, processes for making, and processes for using triglycerides as plasticizers. Triglyceride plasticizers can be produced by recovery of linear or branched C4 to C10 aldehydes from a hydroformylation product, oxidation to the acid with oxygen and/or air, recovery of the resulting acid, and esterification with glycerol, wherein the total carbon number of the triester groups is from 20 to 25 for greater than or equal to 45 wt % of the plasticizer. Such plasticizers can be phthalate-free and provide outstanding properties including a suitable melting or glass transition or pour point, low volatility, increased compatibility, and excellent low temperature properties in a range of polymeric resins.

Abstract: A filter for the removal of substances from blood product has a porous element of a polymeric material consisting of a polyether-ester copolymer or of a polymer blend comprising said copolymer.

Abstract: A medical bag formed of a flexible material includes a front bag part and a rear bag part joined together to form a bag body. A closable liquid inlet port is provided in an upper part of the bag body. The medical bag further includes a deformable elongated member provided in the vicinity of the liquid inlet port on at least one of the front and rear bag parts. The elongated member is deformable so as to retain the liquid inlet port in an open configuration when the elongated member is in a deformed state.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.

Abstract: The present invention relates to a medical tube, comprising an inner layer comprising 50 to 90% by weight of polypropylene-based elastomer and 10 to 50% by weight of polypropylene, based on the total weight of the inner layer; an intermediate layer comprising 45 to 55% by weight of polypropylene-based elastomer and 45 to 55% by weight of polypropylene, based on the total weight of the intermediate layer; and an outer layer comprising 20 to 55% by weight of polypropylene-based elastomer and 45 to 80% by weight of polypropylene, based on the total weight of the outer layer.

Abstract: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.

Abstract: The present invention provides a method for expanding a pre-assembled closed, sterile container system used for the collection, transportation, storage and cryopreservation of biological fluids, such as, blood, bone marrow or umbilical cord blood. The closed sterile bag system comprises a plurality of parts including inlet and or outlet elements and regions for mixing and storing body fluids and cryopreservation liquids, wherein connecting lines provide sterile connection of each component, and wherein the parts are hermetically sealable and separable to maintain sterility system. The methods herein further provide a means for introducing fluids into and/or extracting fluids from a pre-assembled, closed, sterile container system, while maintaining a closed, sterile system without the need to operate under ultra-clean room conditions.

Abstract: Described is a collapsible fluid reservoir that may be expanded during use and collapsible to lie substantially flat when not in use. According to one embodiment, a collapsible fluid reservoir can include a substantially non-rigid container having a substantially open proximal end and a substantially sealed distal end opposite the proximal end defining a cavity therein, wherein the distal end includes at least one fluid outlet port extending therethrough. The collapsible fluid reservoir can also include a substantially rigid cap affixed to the proximal end of the non-rigid container and including at least one fluid inlet port extending therethrough and in fluid communication with the cavity.

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.