Treating Material Introduced Into Body By Contact With Wound Formed Therein By Solid Scarifier, Cutter, Or The Like (e.g., Scratching Skin With Vaccine Coated Needle, Etc.) Patents (Class 604/46)
  • Patent number: 10525244
    Abstract: Microneedle arrays, methods for fabricating microneedle arrays, medical devices, and methods for operating medical devices are provided. A method for fabricating a microneedle array includes providing a sheet blank of material. Further, the method includes stamping the sheet blank of material with a progression of dies, wherein the material is displaced into the microneedle array. A medical device includes a microneedle array, a base member having a first surface supporting the microneedle array and a second surface, and a flexible wall enclosing a chamber between the flexible wall and the second surface of the base member. The flexible wall is biased toward an extended configuration enclosing a first volume in the chamber. Further, the flexible wall is movable to a depressed configuration enclosing a second volume in the chamber less than the first volume.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 7, 2020
    Assignee: Medtronic MiniMed, Inc.
    Inventors: James A. Reitz, Raymond M. Russell, Anthony C. Cannistraci, David Pavell
  • Patent number: 10384047
    Abstract: An article having at least one microneedle (160, 260) is provided. The microneedle includes a base (162), an elongated body (161) having a central axis (130) and a body diameter (168), a tip portion (166), a first channel (170), and a second channel (176). The tip portion includes a tip (164), a beveled surface (140), and a bevel opening (172) in the beveled surface. The first channel extends axially from the bevel opening through at least a portion of the elongated body and has a first wall that is substantially aligned with the central axis. The second channel extends radially from the first channel to the bevel opening and has a second wall that is oriented substantially orthogonal to the central axis. The first channel and second channel merge to form the bevel opening.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 20, 2019
    Assignee: 3M Innovative Properties Company
    Inventor: Ryan Patrick Simmers
  • Patent number: 10300261
    Abstract: A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method including the steps of: forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles; providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface; and removing the needle-shaped body and the support member which are integrally formed from the duplication plate.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: May 28, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventor: Kazuhiko Shiomitsu
  • Patent number: 10252042
    Abstract: The invention relates to a transdermal microneedle unit and a transdermal microneedle drug delivery device comprising the transdermal microneedle unit. The transdermal microneedle unit comprises a plurality of sheets stacked with each, each the sheet having at least one through hole defined thereon and a barbule arranged at the peripheral of the through hole, wherein the through hole on one sheet is penetrated by the barbules of other sheets and the barbules being juxtaposed to form at least one triangular pyramidal transdermal microneedle. The transdermal microneedle drug delivery device comprises a substrate, a transdermal microneedle unit, a union joint and an injection syringe.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: April 9, 2019
    Assignees: JIU-LONG INDUSTRIAL CO., LTD.
    Inventors: Jung-Tang Huang, King-Chun Chang
  • Patent number: 10232158
    Abstract: Provided is a device for surely and easily applying a microneedle patch to a skin. In a case body 2, a pressing member 3 having a tip surface 3a is disposed such that the pressing member is biased in a first direction X1 by a first biasing member. The movement in the first direction X1 is locked by a locking member 7 and a locking part 3g so that the pressing member 3 is brought into a locked state. The locked state is released by pressing a tip of a lock-releasing member 11 against the skin. When the locked state is released, a tip surface 3a of the pressing member 3 is moved in the first direction X1 and the tip surface 3a applies the microneedle patch to the skin.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: March 19, 2019
    Assignee: COSMED PHARMACEUTICAL CO., LTD.
    Inventors: Ying-shu Quan, Fumio Kamiyama
  • Patent number: 10201691
    Abstract: An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: February 12, 2019
    Assignee: 3M Innovative Properties
    Inventors: Dennis G. Berry, Paul A. Martinson, Chin-Yee Ng, Ryan Patrick Simmers
  • Patent number: 10159777
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: December 25, 2018
    Assignees: Sorin Group Italia S.r.l., Politecnico di Milano
    Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
  • Patent number: 10098994
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: October 16, 2018
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Stefano Reggiani, Marta Balzan, Thierry Dupoux
  • Patent number: 9895521
    Abstract: A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: February 20, 2018
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Patrick Mohr
  • Patent number: 9849170
    Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: December 26, 2017
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Kazuya Machida, Seiji Tokumoto, Kazuyoshi Kaminaka, Yuji Ishikawa
  • Patent number: 9717893
    Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: August 1, 2017
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Ryusuke Fudoji, Makoto Ogura
  • Patent number: 9687641
    Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Parminder Singh, Danir Bairamov, Guohua Chen, Robert Wade Worsham
  • Patent number: 9149617
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: October 6, 2015
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Publication number: 20150141910
    Abstract: Disclosed herein are systems and methods relating to microneedles, including a first element including an array of microprojections and a second element including a supportive substrate upon which the microprojections are formed perpendicular to the substrate surface.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Inventors: Raymond J. Francis, Gregory Hunt, Ryan F. Donnelly
  • Publication number: 20150126923
    Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
    Type: Application
    Filed: May 1, 2013
    Publication date: May 7, 2015
    Inventors: Louis D. Falo, JR., Geza Erdos, O. Burak Ozdoganlar
  • Publication number: 20150112250
    Abstract: A buccal microneedle patch may be provided for vaccination. The buccal microneedle patch may include at least one of microneedles. The at least one microneedles may be configured to contain a predetermined vaccine and to penetrate an outside layer of a buccal mucosa for promptly delivering the predetermined vaccine.
    Type: Application
    Filed: April 3, 2013
    Publication date: April 23, 2015
    Inventor: Sung-Yun Kwon
  • Patent number: 9005158
    Abstract: The invention is a non-surgical method for the eradication of pigmentation and scar tissue from an area of skin. The method comprises repeatedly puncturing the area of skin with an array of needles. As the needles are inserted into the skin, the needles and surface of the skin are washed with a clean solution. As the needles are withdrawn from the skin, the flow of clean solution ceases and the dirty solution, which contains cellular fluids and pigments released by the action of the needles, is removed from the surface. The invention is also a solution, which is used to clean the needles and to aid in destroying the pigment containing cells, and an apparatus, which is especially designed to move the needles into and out of the surface of the skin and to provide synchronization of the motion of the needles and flow of the solution such as to maximize the effectiveness of the method.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: April 14, 2015
    Assignee: Hawk Medical Technologies Ltd.
    Inventors: Noam Danenberg, Ori Nesher
  • Publication number: 20150094648
    Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.
    Type: Application
    Filed: April 24, 2013
    Publication date: April 2, 2015
    Inventors: Kiyotsuna Toyohara, Taishi Tanaka, Kazuki Kohno, Takashi Oda, Koichi Masaoka, Katsunori Kobayashi, Masaki Ishibashi, Hidetoshi Hamamoto
  • Patent number: 8979912
    Abstract: Embodiments of dermalogical cell treatment are described generally herein. Other embodiments may be described and claimed.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: March 17, 2015
    Inventors: Jongju Na, Merle Richman
  • Publication number: 20150065950
    Abstract: A device for percutaneous delivery of therapeutic agents includes a head, a wheel rotably mounted on the head, the wheel having an axis of rotation and an outer surface, a plurality of needles disposed upon the outer surface, each needle having a tip projecting away from the axis of rotation of the wheel, and a reservoir mounted on the body, the reservoir containing a fluid, the reservoir having an opening near to the wheel such that the fluid is disposed on the wheel through the opening.
    Type: Application
    Filed: July 25, 2014
    Publication date: March 5, 2015
    Inventor: Maria Banar
  • Publication number: 20150057605
    Abstract: There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.
    Type: Application
    Filed: August 22, 2014
    Publication date: February 26, 2015
    Inventors: Mahmoud Ameri, Peter E. Daddona, Yi Ao
  • Publication number: 20150057604
    Abstract: A puncture device is a device for transferring an active ingredient into a body through a skin by piercing the skin with a microneedle. The puncture device comprises a tubular housing, a piston slidably arranged within the housing and having a main surface intersecting a sliding direction, and a nonlinear coil spring arranged within the housing and providing the piston with a biasing force. A plurality of microneedles are arranged on the main surface side.
    Type: Application
    Filed: April 2, 2013
    Publication date: February 26, 2015
    Inventors: Shunsuke Arami, Makoto Ogura, Seiji Tokumoto
  • Publication number: 20150038897
    Abstract: A low-profile applicator, and a method of manufacturing and use thereof, for impacting microneedles against the stratum corneum of a person having a housing, a diaphragm member having the microneedles, a folding member having interlinking members that hinge-ably rotate with a force member, operatively attached thereto, between a resting position and an extended position. The folding member translates energy stored within the force member when release while retaining the force member in an energized state when in the resting position.
    Type: Application
    Filed: July 30, 2014
    Publication date: February 5, 2015
    Inventors: Peter E. Daddona, Cedric Wright, Matt Vargas, Vivian Lee, Jessica Heasley
  • Patent number: 8940013
    Abstract: A human skin treatment arrangement configured to treat surface conditions of human skin, especially the wrinkle, fine lines or scar appeared on the surface of human face, or for improving absorption efficiency of cosmetic or medical transdermal agent. In a treatment mode, the arrangement is configured for attaching to a portion of human skin such that the area of the human skin under treatment is maintained in a stretched position to enhance the treatment effect. In a further embodiment, the arrangement comprises a wrinkle relief agent, a scar relief agent or a cosmetic or medical transdermal agent to treat the surface of the skin.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 27, 2015
    Inventor: Peter Ar-Fu Lam
  • Publication number: 20150025452
    Abstract: Disclosed are methods for the use of a truncated, recombinant laminin-511 for modifying hair growth as well as delivery devices, kits and methods for topically administering truncated, recombinant laminin-511. Furthermore disclosed are delivery devices, kits and methods using modulators of full-length laminin-511 expression or function to decrease hair growth in areas of unwanted hair growth.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 22, 2015
    Inventors: M. Peter Marinkovich, Jing Gao, Xiaoyu Xu, Jayakumar Rajadas
  • Publication number: 20150018755
    Abstract: A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques.
    Type: Application
    Filed: July 10, 2014
    Publication date: January 15, 2015
    Inventors: Mei-Chin CHEN, Kuan-Ying LAI, Chun-Wei LIN, Ming-Hung LING
  • Publication number: 20140378887
    Abstract: A skin treatment device includes a handle and a tip, having a skin applying surface, detachably coupled to the handle. A fluid delivery structure is formed at skin applying surface and has an aperture and a vacuum entry port. A fluid detouring path is defined between the aperture and the vacuum entry port for prolonging a traveling path of fluid from the aperture and the vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 25, 2014
    Inventors: Franklin J. Chang, Henry Ping Chang
  • Publication number: 20140364801
    Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 11, 2014
    Inventors: Joseph C. Trautman, Richard L. Keenan
  • Patent number: 8900180
    Abstract: Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: December 2, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: James T. Wolter, John K. Simons, Peter R. Johnson
  • Patent number: 8900194
    Abstract: Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: December 2, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Graham M. Clarke, Michael D. Delmore, Michael K. Domroese, Richard H. Ferber, Jay D. Jacobs, Jamieson C. Keister, Franklyn L. Frederickson
  • Patent number: 8900181
    Abstract: A new minimally invasive surgical approach is proposed that contemplates a method and apparatus for tightening lax skin without visible scarring via a device in various surgical procedures such as plastic surgery procedures. In some embodiments, the device is a single use disposable instrument. This approach circumvents surgically related scarring and the clinical variability of electromagnetic heating of the skin and performs small multiple pixilated resections of skin as a minimally invasive alternative to large Plastic surgical resections of skin. This approach can also be employed in areas of the body that are currently off limits to plastic surgery due to the visibility of the surgical scar. In addition, the approach can perform a skin grafting operation by harvesting the transected incisions of skin from a tissue site of a donor onto a skin defect site of a recipient with reduced scarring of the patient's donor site.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: December 2, 2014
    Assignee: SRGI Holdings, LLC
    Inventor: Edward W. Knowlton
  • Patent number: 8882717
    Abstract: A multi-site injection system (10) in accordance with the present invention generally includes a plurality of medicament delivering needles/microprotrusions (18) along with a support therefore. A supply of medicament (36) is provided and a means provided for supplying the medicament to the plurality of needles/microprotrusions in order to effect delivery into a stratum corneum (42) of a user.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: November 11, 2014
    Assignee: Allergan, Inc.
    Inventors: Steven D. Kimmell, Scott J. Gerondale
  • Publication number: 20140330289
    Abstract: A handheld apparatus including (a) a motorized hand-piece including a mechanical rotatable coupling shaft which is caused to rotate so that it imparts a rotating motion to the coupling shaft; (b) an interface cup member which includes a body with an exterior surface having hook and loop fasteners thereon and a lower surface with an interface opening which is affixed to the coupling member of the mechanical rotatable shaft; and (c) the hand-piece individually retaining a multiplicity of different interchangeable components which are used for different purposes, each different component affixed on one surface to the hook and loop fasteners of the interface cup and which rotate when the motorized hand piece is energized and causes the interface cup to rotate.
    Type: Application
    Filed: May 6, 2013
    Publication date: November 6, 2014
    Applicant: SPA DE SOLEIL, INC.
    Inventor: Jacob Revivo
  • Publication number: 20140330198
    Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 6, 2014
    Inventors: Ying Zhang, Percy T. Fenn, Peter R. Johnson
  • Publication number: 20140316333
    Abstract: A dissolving solid solution perforator (SSP) patch for oral cavity administration may include at least one perforator. The at least one perforator may contain a first drug and be configured to pierce an outside layer of an oral cavity for promptly delivering the first drug. The at least one perforator may penetrate an epithelium layer of the oral cavity and to deliver the antimigraine drug into blood vessels in a submucosa layer.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 23, 2014
    Inventor: Sung-Yun KWON
  • Patent number: 8864788
    Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: October 21, 2014
    Assignee: Medtronic Xomed, Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Patent number: 8864743
    Abstract: Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The non-cutting scoring elements have drugs and other active substances coated over a portion thereof or incorporated within internal structure of the element so that the drug is released into the luminal wall closely associated diseased regions of the body lumen as the non-cutting scoring structure is radially expanded into the wall.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: October 21, 2014
    Assignee: AngioScore, Inc.
    Inventors: Eitan Konstantino, Michal Konstantino
  • Publication number: 20140294919
    Abstract: The present invention relates to efficient devices for administration of pharmaceutical agents into the skin of the human body. In particular the present invention provides devices for vaccination into the skin. The present invention provides a pharmaceutical agent delivery device having skin-piercing portion comprising a solid reservoir medium containing the pharmaceutical agent, wherein the reservoir medium is coated onto the skin piercing portion. Alternatively, the skin piercing portion may consist of the solid pharmaceutical agent reservoir medium. The pharmaceutical delivery devices are proportioned such that agent is delivered into defined layers of the skin, and preferred delivery devices comprise skin-piercing portions that deliver the pharmaceutical agent into the epithelium or the dermis. Preferred reservoir media comprise sugars, and in particular stabilising sugars that form a glass such as lactose, raffinose, trehalose or sucrose.
    Type: Application
    Filed: April 25, 2013
    Publication date: October 2, 2014
    Inventors: Colin Cave DALTON, Richard Lewis Easeman, Nathalie Garcon
  • Publication number: 20140276378
    Abstract: Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: Corium International, Inc.
    Inventors: Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh
  • Publication number: 20140276366
    Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: Corium International, Inc.
    Inventors: Doug Bourne, Ashutosh Shastry, Anthony Le, Parminder Singh
  • Publication number: 20140236075
    Abstract: According to one embodiment, a method for manufacturing a hollow needlelike object including a hollow part inside includes: a step of preparing a first needlelike-object base having a face comprising a groove forming at least a part of the hollow part; and a step of covering the face of the needlelike-object base with a covering member.
    Type: Application
    Filed: April 24, 2014
    Publication date: August 21, 2014
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventor: Hiroshi SUGIMURA
  • Patent number: 8784363
    Abstract: An applicator device (20) including a housing (22), an impactor (62) for impacting a microneedle array and accelerating the microneedle array toward the target site, wherein the impactor is capable of moving along an arcuate path to move the microneedle array toward the target site. Also, an applicator device including a housing, a patch applicator pivotally supported by the housing, and a torsion spring. The patch applicator has a retaining portion (40) and a patch contacting portion (70), and the patch contacting portion is capable of moving along a substantially arcuate path between a first position and a second position. The torsion spring is capable of biasing the patch applicator relative to the housing.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: July 22, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Franklyn L. Frederickson, Michael D. Johnson
  • Publication number: 20140200508
    Abstract: An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, and (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin.
    Type: Application
    Filed: June 21, 2013
    Publication date: July 17, 2014
    Inventors: Isaac D. Cohen, Daniela Bratescu, E. Althea Knight, Thomas Mammone
  • Publication number: 20140200509
    Abstract: An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of dissolvable microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin, and (d) wherein said dissolvable microneedles are configured as a dissolvable exterior shell and said shell encapsulates one or more cosmetic agents.
    Type: Application
    Filed: June 21, 2013
    Publication date: July 17, 2014
    Inventors: Issac David Cohen, Daniela Bratescu, E. Althea Knight, Thomas Mammone
  • Patent number: 8771781
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: July 8, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20140188041
    Abstract: A method is provided for fabricating a microneedle or a microneedle array using a mould (2) having at least a needle-forming cavity which comprises the step (A) of prefilling the needle-forming cavity with a solvent (1) before applying a microneedle-forming composition (3). The solvent (1) and microneedle-forming composition (3) are allowed to mix (step E) as a result of diffusion. The solvent is removed (step F), a flexible adhesive tape (4) can be applied on top of the mould (2), (step G), lifted (step H) so as to pull the microneedles out of the mould, giving an array of drug-filled dissolvable microneedles ready for application (step I).
    Type: Application
    Filed: May 8, 2012
    Publication date: July 3, 2014
    Applicant: UNIVERSITY COLLEGE CORK
    Inventors: Anne Moore, Anto Vrdoljak
  • Publication number: 20140180201
    Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: CORIUM INTERNATIONAL, INC.
    Inventors: Zhongli Ding, Guohua Chen, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Patent number: 8753318
    Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: June 17, 2014
    Assignee: Alza Corporation
    Inventors: Joseph C. Trautman, Richard L. Keenan
  • Patent number: 8741377
    Abstract: A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: June 3, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Hannah H. Choi, Gordon P. Knutson, Moses M. David
  • Publication number: 20140107566
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicants: Georgia Tech Research Corporation, Emory Univeristy
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel