Filter Means Patents (Class 604/6.09)
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Patent number: 8105265Abstract: A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.Type: GrantFiled: October 10, 2008Date of Patent: January 31, 2012Assignee: DEKA Products Limited PartnershipInventors: Jason A. Demers, Larry B. Gray, James D. Dale, N. Christopher Perry, David E. Altobelli
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Publication number: 20120016285Abstract: A catheter for use in accessing the vasculature of a patient and for optionally transferring a volume of blood from a patient to a hemodialysis machine. The catheter includes one or more connectors, which are secured to a transition member of the catheter. The one or more connectors have a threaded securement component for facilitating the securement of a secondary apparatus, such as an extension tube member to the one or more connectors.Type: ApplicationFiled: July 8, 2011Publication date: January 19, 2012Applicant: INTER-NOVATION INC.Inventor: Sohail Contractor
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Patent number: 8097162Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.Type: GrantFiled: November 17, 2010Date of Patent: January 17, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
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Patent number: 8097153Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.Type: GrantFiled: April 13, 2010Date of Patent: January 17, 2012Assignee: The Trustees of Columbia in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
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Publication number: 20120010554Abstract: Apparatus for controlling an extra-corporeal blood treatment in a medical device, comprising a blood treatment device (7), an extra-corporeal blood transport line (4), a fluid transport line (3) for a treatment fluid for the blood, at least a sensor adapted to provide a measure (M) correlated to at least a treatment parameter of the extra-corporeal blood treatment and/or of the treatment device (7) in the medical device (1), at least one storage memory (29), and at least a control device (28), operatively connected at least with the storage memory (29) and with the sensor, and configured for receiving the measure (M) from the sensor, correlating the measure (M) with referential data (R) of the treatment device for the treatment parameter provided by the at least one storage memory (29), and correlating the measure (M) with patient historical data (H) for the treatment parameter for obtaining an information representative of the quality of the extra-corporeal blood treatment.Type: ApplicationFiled: July 1, 2011Publication date: January 12, 2012Inventors: Georges VANTARD, Bernard BENE
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Patent number: 8092684Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.Type: GrantFiled: November 17, 2010Date of Patent: January 10, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
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Patent number: 8088090Abstract: This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.Type: GrantFiled: September 8, 2006Date of Patent: January 3, 2012Assignee: CaridianBCT, Inc.Inventors: Thomas J. Felt, Marlene Adele Bainbridge
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Patent number: 8083706Abstract: The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.Type: GrantFiled: July 7, 2009Date of Patent: December 27, 2011Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Nina C. Shapley, Zhongliang Tang
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Patent number: 8075510Abstract: A system for removing undesirable material from vessels and from chambers within the heart is provided. The system includes a suction cannula for removing the undesirable material from a site of interest within a patient. A filter device may be provided for capturing the undesirable material and removing it from the fluid flow. The system also includes pump for generating the necessary suction force through the suction cannula to dislodge the undesirable material from the site of interest and for generating a sufficient driving force to direct the fluid flow downstream within the system. The system further includes a reinfusion cannula for introducing fluid removed from the site of interest back into a patient. A method for removing undesirable material from vessels and from heart chambers is also provided.Type: GrantFiled: August 6, 2008Date of Patent: December 13, 2011Assignee: Vortex Medical, Inc.Inventors: Lishan Aklog, Michael Glennon
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Patent number: 8075509Abstract: A medical apparatus (1) comprises a user interface (30), a number of sensors (16,27,21,22,29) and a control system (18) programmed for displaying on the user interface screen (31) a number of indicia (37), each relating to a corresponding parameter and comprising an indicium border (45) delimiting an indicium selection area (45a); the control system allows selection of an indicium for identifying the parameter a user intends to modify, allows setting of a new set value for the selected parameter; the control system also receives from the sensors (29) a measure of the actual value for the parameter and displays on the indicium selection area (45a) of the indicium both the actual value and the set value for the same parameter. The programming software for the control system is also disclosed.Type: GrantFiled: August 25, 2005Date of Patent: December 13, 2011Assignee: Gambro Lundia ABInventors: Fabrizio Molducci, Fabio Roncadi, Paolo Rovatti
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Patent number: 8070707Abstract: A device for continuously measuring osmotic pressure of blood flowing through an extracorporeal blood circuit including: a blood passage further comprising a withdrawal blood passage connectable to a blood vessel in a patient and an infusion blood passage connectable to a blood vessel in a patient; a filter further comprising a filtrate chamber, a blood chamber and a permeable membrane separating the filtrate chamber and blood chamber, wherein the blood chamber is in fluid communication with the blood passage; a pressure sensor measuring a pressure difference between the filtrate chambers and the blood chamber, and a controller receiving a pressure signal from the pressure sensor, determining an osmotic pressure across the permeable membrane of the filter, and adjusting a rate of removal of fluid from blood in the filter if the determined osmotic pressure level varies from a predetermined osmotic pressure setting.Type: GrantFiled: July 14, 2008Date of Patent: December 6, 2011Assignee: CHF Solutions, Inc.Inventors: Mark Gelfand, John J. O'Mahony, Howard R. Levin
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Patent number: 8070706Abstract: Method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, directing backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed. The backflush fluid, preferably a normal saline solution, may contain an anticoagulant such as heparin, citrate or NO donor in suitable concentration for systemic anti-coagulation or for treating the fiber for thromboresistance.Type: GrantFiled: January 13, 2009Date of Patent: December 6, 2011Assignee: Transvivo, Inc.Inventors: Reynolds G. Gorsuch, Tommy Gene Cooper, Harold H. Handley, Jr., Harold W. Peters
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Publication number: 20110282262Abstract: A Continuous Ambulatory Haemofiltration consisting of an outer casing, multifunction pump, haemofilter, reversed osmosis filter, power source, drainage bag, blood lines and fluid lines, characterized in that the haemofiltrate from the haemolfilter is moved to a reversed osmosis filter. The ultrafiltrate fluid from the reversed osmosis filter flows to the out-flow tube of the haemofilter veineus line through a specific fluid line. The exit of the reversed osmosis filter is connected to a drainage bag. The multifunction pump moves blood from the jagular perm catherter to the haemofilter, and fluids between the haemofilter, reversed osmosis filter, veineus line and drainage bag. An electrode is placed at the in-flow tube of the haemofilter to measure incoming blood osmolality. The electrode is connected to a microprocessor that is further connected to a computer-controlled valve at the out-flow line of the reversed osmosis filter. The microprocessor is connected with a memory card.Type: ApplicationFiled: October 1, 2009Publication date: November 17, 2011Inventor: Fahad Ahmed Alkanhal
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Patent number: 8057419Abstract: An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.Type: GrantFiled: January 17, 2006Date of Patent: November 15, 2011Assignee: Sorin Group USA, Inc.Inventors: Bruce S. Ellingboe, William D. Dalke, J. Steven Ingebrigtsen, John J. Kappus, Bruce E. Lawrence, Mike E. Schwab, Gary A. Carson, Kevin J. Kollar
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Patent number: 8052632Abstract: A cardiotomy reservoir, comprising an outer wall provided, at the lid, with connectors for the inflow of blood to be filtered and, at the bottom, with a connector for the outflow of the filtered blood, a filtering mass being provided which divides the space delimited by the outer wall into a portion that is connected to the inflow connectors and a portion that is connected to the outflow connector; the cardiotomy reservoir comprises a layer of material adapted to retain fats present in blood, and further comprises a first partition and a second partition, which are adapted to delimit at different distances the region that comprises the blood outflow connector and are provided with ports for the passage of the blood in its path for accessing the connector which are arranged at differentiated levels with respect to the bottom, the ports that are provided in the first partition that lies closest to the outflow connector being located at a height, from the bottom, that is greater than the height of the ports provType: GrantFiled: March 27, 2009Date of Patent: November 8, 2011Assignee: Eurosets S.r.l.Inventors: Nicola Ghelli, Edgardo Costa Maianti, Roberto Balanzoni, Antonio Petralia
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Patent number: 8048209Abstract: A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).Type: GrantFiled: November 2, 2004Date of Patent: November 1, 2011Assignee: Gambro Lundia ABInventors: Jürgen Dannenmaier, Hermann Goehl, Thomas Ertl, Jacques Chevallet, Francesco Ribolzi
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Patent number: 8048310Abstract: A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significant increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.Type: GrantFiled: December 22, 2010Date of Patent: November 1, 2011Assignee: Gambro Lundia ABInventors: Jan Sternby, Berit Sternby
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Publication number: 20110251544Abstract: A filter and a method treat blood borne carcinomas by inducing apoptosis in carcinoma cells. The filter includes comprises a stent having an interior wall defining a channel containing a packing material and at least one antineoplastic agent. The method includes placing a patient's blood in apposition of the antineoplastic agent by pumping the blood through the stent. The blood remains in apposition to the antineoplastic agent for a sufficient time period to induce an apoptotic cascade.Type: ApplicationFiled: November 11, 2009Publication date: October 13, 2011Applicant: Marv Enterprises LLCInventor: Mitchell S. Felder
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Publication number: 20110237997Abstract: A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit.Type: ApplicationFiled: October 8, 2009Publication date: September 29, 2011Inventors: Josef Beden, Itka Bado, Georg Verch
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Patent number: 8021319Abstract: A blood set comprises an arterial line having a patient end provided with a multiport connector (14) having first port (15) connected to a blood transport tube (13), a second port (16) bearing a male luer connector for connecting to a vascular access device (17), and a third port (18) connected to a service tube (20) terminating with female luer connector (23) for connection with a priming liquid supply line. The blood set operates rapidly and with a small risk of contamination for the patient.Type: GrantFiled: October 27, 2005Date of Patent: September 20, 2011Assignee: Gambro Lundia ABInventors: Annalisa Delnevo, Roberto Neri
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Patent number: 8021318Abstract: The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.Type: GrantFiled: November 9, 2010Date of Patent: September 20, 2011Assignee: The Trustees of Columbia University in the City of New YorkInventors: Edward F. Leonard, Alan C. West, Nina C. Shapley, Zhongliang Tang
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Patent number: 8012114Abstract: A haemodialysis device having an emergency activating function is provided. In order to avoid critical drops in blood pressure during a dialysis treatment, the emergency activating function makes it possible for the operating staff to initiate with a single control function a blood pressure measurement and a delivery of substance into the patient's blood in the event of a hypotensive episode and at the same time to have the introduction of these measures by the haemodialyser confirmed clearly through a display having an outward appearance different from that displayed during normal operations. In addition, further automatically introduced process steps can be provided. The emergency activating function speeds up the implementation of the measures to be introduced and, at the same time prevents incorrect operation and makes it possible for the operating staff to attend directly to the patient.Type: GrantFiled: May 14, 2005Date of Patent: September 6, 2011Assignee: Fresenius Medical Care Deutschland GmbHInventors: Pia Daniel, Carsten Mueller
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Publication number: 20110213289Abstract: The present invention relates to a blood purification apparatus for extracorporeally circulating the blood of a patient so as to purify the blood for medical treatment incorporating a dialyzer and a method for priming the blood purification apparatus, wherein the present invention provides a blood purification apparatus and its priming method which can simply and easily automate the priming operation and also can surely and smoothly perform the bubble purging of the dialyzer.Type: ApplicationFiled: December 15, 2009Publication date: September 1, 2011Applicant: NIKKISO CO., LTD.Inventors: Masahiro Toyoda, Satoshi Takeuchi
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Publication number: 20110213290Abstract: A system for removing undesirable material from vessels and from chambers within the heart is provided. The system includes a suction cannula for removing the undesirable material from a site of interest within a patient. A filter device may be provided for capturing the undesirable material and removing it from the fluid flow. The system also includes pump for generating the necessary suction force through the suction cannula to dislodge the undesirable material from the site of interest and for generating a sufficient driving force to direct the fluid flow downstream within the system. The system further includes a reinfusion cannula for introducing fluid removed from the site of interest back into a patient. A method for removing undesirable material from vessels and from heart chambers is also provided.Type: ApplicationFiled: April 6, 2011Publication date: September 1, 2011Inventors: Albert K. Chin, Lishan Aklog, Brian deGuzman, Thomas A. Kramer, Michael Glennon
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Publication number: 20110208107Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient.Type: ApplicationFiled: December 7, 2010Publication date: August 25, 2011Applicant: LIFEBRIDGE Medizintechnik AGInventors: Gerhard Müller-Spanka, Hans-Reinhard Zerkowski
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Publication number: 20110208106Abstract: An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.Type: ApplicationFiled: May 2, 2011Publication date: August 25, 2011Applicant: CHF SOLUTIONS, INC.Inventors: Howard R. Levin, Mark Gelfand, John O'Mahony, Hans-Dietrich Polaschegg
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Publication number: 20110208108Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as cardiopulonary bypass graft surgery, keyhole cardiopulonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous etherectomy.Type: ApplicationFiled: December 7, 2010Publication date: August 25, 2011Applicant: LIFEBRIDGE Medizintechnik AGInventors: Gerhard Müller-Spanka, Hans-Reinhard Zerkowski
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Publication number: 20110201988Abstract: A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle.Type: ApplicationFiled: October 12, 2009Publication date: August 18, 2011Inventors: Mattias Holmer, Lennart Jönsson, Anders Wallenborg, Per Hansson
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Patent number: 7998100Abstract: The present invention provides a bilirubin reducing means which can minimize a risk such as the onset of an infection or the occurrence of blood coagulation and can reduce physical, temporal and economical burdens imposed on a patient suffering from liver dysfunction.Type: GrantFiled: June 30, 2006Date of Patent: August 16, 2011Assignee: National University Corporation Okayama UniversityInventors: Yoshimasa Takeda, Kiyoshi Morita
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Patent number: 7993297Abstract: Equipment for controlling blood flow in an extra-corporeal blood circuit, comprising at least a first sensor (11), designed to measure an arterial pressure (Part) upstream of a peristaltic pump (9); at least a second sensor (12), designed to measure an angular velocity (?) of the peristaltic pump; a memory (14) designed to store at least one set value (Qset) of the desired blood flow through the access branch, and a calibration function (F) in to at least the variables (v1), related to the angular velocity (?) of the pump, (v2), related to the arterial pressure (Part) in the portion of the said access branch upstream of the peristaltic pump, (v3), related to an actual flow of blood (Qactual) through the said access branch; and at least one control unit (13), capable of calculating an actual flow value (Qactual) by applying the function F to the values of angular velocity and arterial pressure (Part, ?) measured by the sensors; comparing the actual flow (Qactual) with the desired flow (Qset); and varying the aType: GrantFiled: May 26, 2009Date of Patent: August 9, 2011Assignee: Gambro Lundia ABInventors: Luca Vinci, Francesco Fontanazzi
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Patent number: 7993516Abstract: The invention relates to an integrated blood treatment module (1) comprising a support element (4) and a fluid distribution circuitry associated thereto; the distribution circuitry comprises at least a blood line (44), a portion of which is secured to the support element and defines with the latter at least a U-shaped tube length (44a) designed to cooperate, when in use, with a respective pump (3a). There are then further fluid lines (45, 48, 50, 51) fastened to the support element and defining each at least a U-shaped tube length (45a, 48a, 50a, 51a) with respect to said element and each designed to cooperate, when in use, with a respective pump (3b, 3c, 3d, 3e). The support element has a first zone (274) in which the portion of the blood line is secured, and at least a second zone (275) opposite said first zone, to which all the corresponding further tube lengths are fastened.Type: GrantFiled: April 6, 2007Date of Patent: August 9, 2011Assignee: Gambro Lundia ABInventors: Claudio Tonelli, Vincenzo Baraldi, Massimo Zaccarelli, Annalisa Delnevo, Francesco Ribolzi, Jacques Chevallet, Jacques Duchamp, Aziz Aberkane, Gabriel Meyssonnier, Dominique Pouchoulin
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Publication number: 20110190680Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: ApplicationFiled: September 29, 2009Publication date: August 4, 2011Inventors: Yoram Vodovotz, Gregory Constantine, Jorg Christian Gerlach, Qi Mi, Maxim Mikheev, David Okonkwo, Alexey Solovyev
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Patent number: 7985196Abstract: A method and a hemodialysis machine provide for at least partial emptying of an extracorporeal blood circulation after patient blood in the circulation has been returned to the patient via an infusion liquid which displaces the blood. The method includes emptying at least a blood chamber of a hemodialyzer subdivided by a semipermeable membrane into the blood chamber and a dialysis fluid chamber without additionally connecting an arterial blood line and a venous blood line of the circulation to one another. The arterial blood line is actively or passively aerated at a first point and the venous blood line is actively or passively aerated at a second point. The infusion liquid is emptied through the membrane into the dialysis fluid chamber and then via a dialysis fluid discharge line. The method is operable by a control program that runs automatically without requiring any manual input after activation of the program.Type: GrantFiled: March 6, 2007Date of Patent: July 26, 2011Assignee: Fresenius Medical Care Deutschland GmbHInventors: Pascal Kopperschmidt, Joachim Noack
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Patent number: 7981280Abstract: An extracorporeal blood treatment apparatus includes a blood treatment unit, a treatment fluid circuit, and a blood circuit. The treatment fluid circuit has a treatment fluid pump for circulating treatment fluid around the treatment fluid circuit and through the blood treatment unit. The blood circuit has a dual chamber blood pump for circulating blood around the blood circuit and through the blood treatment unit. An arterial line withdraws blood from a patient and delivers the withdrawn blood to the blood treatment unit. A venous line returns the treated blood to the patient. The arterial and venous lines can be switched between a first condition in which they are connected to the patient and a second condition in which they are disconnected from the patient and connected to each other for recirculation of blood through the blood circuit.Type: GrantFiled: May 31, 2006Date of Patent: July 19, 2011Assignee: Renal Solutions, Inc.Inventors: David J. Carr, Stephen R. Ash
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Patent number: 7971728Abstract: A filtration system for collecting bone fragments during surgery performed on a patient includes a cylinder having a rotating disk with circumferential arms extending radially in the cylinder to define pockets. The rotating disk includes a longitudinal hub that carries an outlet connected to a central passageway formed in the disk. A plurality of apertures on the disk permit the liquid to flow into the passageway and through the outlet while the pockets retain the bone fragments. The disk is rotated to align circumferential spaced pockets to align with the inlet and outlet ports. The disks includes bearing surfaces that permit the rotation thereof and the arms are spaced from the cylinder inner surface to allow the flow of fluid in the event the pockets fill and clog the apertures and prevent flow into the outlet passage.Type: GrantFiled: February 28, 2006Date of Patent: July 5, 2011Assignee: The Anspach Effort, IncInventors: Thomas D. Anspach, Stephen M. Bucina
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Publication number: 20110160636Abstract: An extracorporeal device for inhibiting alternative complement pathway activation includes a support structure an anti-complement antibody disposed on or within the support structure and a first conduit for conducting blood of the subject to the anti-complement antibody. The anti-complement antibody can bind to the complement protein and remove the complement protein from the blood.Type: ApplicationFiled: September 10, 2009Publication date: June 30, 2011Inventor: Rekha Bansal
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Patent number: 7959593Abstract: A blood purification apparatus includes a blood circuit, a blood purifying device, a driving device, an air bubble detection device, and a connection condition evaluation device. The blood circuit is provided with arterial and venous blood circuits, to which needles are attached at ends thereof. The blood purifying device is connected between the arterial and venous circuits. In a blood purifying treatment after a priming operation, the driving device drives the blood in the arterial blood circuit in a forward direction, and drives the blood in the venous blood circuit in a reverse direction. The air bubble detection device detects air bubbles in a liquid flowing in the arterial and venous blood circuits. The connection condition evaluation device evaluates connection conditions of the needles to the ends of the arterial and venous blood circuits based on the detection by the air bubble detection device.Type: GrantFiled: November 15, 2006Date of Patent: June 14, 2011Assignee: Nikkiso Co., Ltd.Inventors: Yoshiro Ueda, Hiroshi Nimura
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Publication number: 20110137224Abstract: A disposable single-needle extracorporeal blood treatment circuit for such treatments of blood hemofiltration, plasma filtration, detoxification and alike includes a manually operated syringe attached to a proximal bifurcation and a patient's access port attached to a distal bifurcation. Both bifurcations are connected with each other by a withdrawal line and in parallel by a treatment loop including a blood treatment unit and an air removal element. In the first embodiment, one or two three-way valves (such as stop-cocks) are positioned at these bifurcations to allow directing the flow of blood from the patient to the syringe through the withdrawal line and redirecting the flow through the treatment loop when blood is being returned to the patient from the syringe. In a second embodiment, two check valves are positioned along said withdrawal line and said treatment loop to automatically direct the blood floe in the same manner.Type: ApplicationFiled: December 9, 2009Publication date: June 9, 2011Inventor: Araz Ibragimov
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Patent number: 7955291Abstract: A switch valve for use in an extracorporeal blood flow circuit comprises a valve housing having a chamber, four openings communicating with the chamber, and a valve member located in the valve chamber. A first opening is to be connected to a patient via an arterial cannula, a second opening is to be connected to a patient via an venous cannula, a third opening is to be connected to a first inlet/outlet of a blood treatment device, and a fourth opening is to be connected to a second inlet/outlet of a blood treatment device. The valve member is movable within the valve housing to fluidly connect the first opening to either the third or the fourth opening and to fluidly connect the second opening to either the third or the fourth opening. The width of the valve member is smaller than a peripheral dimension of the openings.Type: GrantFiled: August 27, 2009Date of Patent: June 7, 2011Assignee: Gambro Lundia ABInventor: Jan Peter Sternby
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Publication number: 20110125073Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.Type: ApplicationFiled: December 23, 2010Publication date: May 26, 2011Inventors: Edmond Rambod, Victor Gura
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Method for monitoring an arrangement for determining the concentration of an analyte in a body fluid
Patent number: 7949477Abstract: The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.Type: GrantFiled: December 23, 2008Date of Patent: May 24, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Helmut Rinne, Gregor Ocvirk -
Patent number: 7947007Abstract: A bubble trap for removing bubbles from blood flowing through an extracorporeal circuit includes device body possessing blood inlet and outlet ports, and a negative-pressure chamber at the upper part of the device body that is adapted to be connected to a gas evacuator at a gas outlet port so that a negative-pressure state can be kept therein. Two communication passages provide communication between the gas outlet port and the device body. On the first communication passage, a liquid-repellant or water-repellent filter is provided in a manner crossing the passage. On the second communication passage, a valve member is arranged. Within the device body, a buoyant float is provided. A mechanism is provided to remove bubbles from the blood by the cooperation of the float and the valve member.Type: GrantFiled: April 9, 2007Date of Patent: May 24, 2011Assignee: Terumo Kabushiki KaishaInventors: Hidetaka Nakayama, Mitsuaki Ogihara, Kazuhiko Takeuchi
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Publication number: 20110118647Abstract: An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.Type: ApplicationFiled: July 3, 2009Publication date: May 19, 2011Applicant: GAMBRO LUNDIA ABInventors: Francesco Paolini, Francesco Fontanazzi, Fabio Grandi
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Patent number: 7942842Abstract: The invention relates to an apparatus and a method for the treatment of the blood in a Continuous Renal Replacement Therapy, using a machine which comprises: —connecting means from and to respective blood vessels of a patient; —blood processing means comprising a pump; —means for adding drugs or other therapeutic substances to the blood being treated; —means for feeding refill liquid into the blood; —blood filtration means, cascade-connected to one another by relative conduits, said conduits and said connecting means defining a blood path; wherein the blood to be treated passes through an oxygenating device which comprises an oxygenating membrane and is located upstream from said blood filtration means and downstream from said blood processing means, so that the blood is treated by said oxygenating membrane without the intake pressure along the portion upstream from the blood pump; and wherein the blood is pumped downstream from the connecting means to the oxygenating device at a flow rate of about 280-300 mlType: GrantFiled: March 6, 2008Date of Patent: May 17, 2011Assignee: Freeview Ventures LLCInventor: Florenziano Della Torre
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Patent number: 7938792Abstract: An extracorporeal therapy machine removes blood from a patient in order to treat the blood and then return the blood to the patient. If the removal needle or the return needle is dislodged and blood is not returned, the patient may suffer a great blood loss. A new technique for detecting dislodgement uses the normal, initial values of a plurality of parameters of the patient and the therapy machine to set criteria or limits for an alarm, and then adjusts those criteria based on the later values of those parameters as they change during one therapy or over several therapies experienced by the patient.Type: GrantFiled: October 1, 2007Date of Patent: May 10, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Rodolfo G. Roger, Michael E. Hogard, Joel Tejedor
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Patent number: 7935071Abstract: A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.Type: GrantFiled: December 19, 2007Date of Patent: May 3, 2011Assignee: CHF Solutions, Inc.Inventors: Howard R. Levin, Mark Gelfand, John O'Mahony, Hans-Dietrich Polaschegg
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Publication number: 20110098623Abstract: Methods and devices for selectively removing from a subject a target cell, pathogen, or virus expressing a binding partner on its surface are presented. In one embodiment, the device contains an excorporeal circuit, which includes, at least, a magnetic filter comprising a magnet and a removable, magnetizable substrate capable of capturing magnetic nanomaterials; and a pump in fluid communication with the magnetic filter, wherein the pump moves fluid through the excorporeal circuit. The magnet is capable of generating a magnetic field sufficient to capture magnetic nanomaterials in the magnetic field. In a preferred embodiment, the target cells are cancer cells and/or cells infected with pathogenic agents. The devices may be designed for extracorporeal or in vivo uses. Functionalized superparamagnetic nanoparticles are either mixed ex vivo with a biological fluid from the patient or injected into the patient.Type: ApplicationFiled: June 17, 2009Publication date: April 28, 2011Inventors: Zhongju John Zhang, Kenneth Edward Scarberry, Erin Beth Dickerson, John Francis McDonald
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Publication number: 20110098625Abstract: In a hemodiafiltration apparatus, a control and command unit (11) halts a replacement fluid supply pump (8) and contemporaneously modifies the control mode of a blood pump (1) passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor (12) arranged downstream of a hemodiafilter (3). The aim is to prevent risks due to excessive hemo-concentration in the blood circuit between the ultrafiltration zone and the infusion zone.Type: ApplicationFiled: May 26, 2008Publication date: April 28, 2011Applicant: GAMBRO LUNDIA ABInventors: Pietro Masala, Mauro Suffritti, Anders Wallenborg, Thomas Gebhart
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Publication number: 20110098624Abstract: A method of removing toxins from blood from a patient in need of such toxin removal includes: providing a countercurrent dialysis filter (20) having a blood compartment and a dialysate compartment separated from the blood compartment by a semi-permeable membrane; conveying blood from the patient through the blood compartment of a countercurrent filter (20) an back to the patient; and drawing dialysate from a reservoir (32) through the dialysate compartment of the countercurrent filter (20). At least one of the blood or dialysate experiences pulsatile flow. The steps are carried out such that blood toxins are drawn from the blood compartment through the semi-permeable membrane into the dialysate compartment.Type: ApplicationFiled: February 6, 2002Publication date: April 28, 2011Inventors: Craig McCotter, Paul Bolin
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Patent number: 7931610Abstract: A blood purification apparatus that can make the specific peak to be imparted to the blood more distinct, and therefore can detect blood recirculation reliably and precisely, is presented. It contains a blood circuit route, a blood pump, a dialyzer, dialysate introduction and discharge lines, a duplex pump, a pressurizing pump, a blood concentration means, and detection means that detect the specific peak imparted by the blood concentration means. The blood concentration means is configured to have an atmosphere release line, the tip of which is open to the atmosphere, that extends from between the pressurizing pump and the duplex pump in the dialysate discharge line, and to have an electromagnetic valve that can open or close the atmosphere release line. The electromagnetic valve opens the atmosphere release line to impart the specific peak by rapidly concentrating the blood flowing in the dialyzer for a short period of time.Type: GrantFiled: July 17, 2008Date of Patent: April 26, 2011Assignee: Nikkiso Co., Ltd.Inventors: Tomoya Murakami, Masahiro Toyoda, Akari Agata