Constituent Removed From Blood And Remainder Returned To Body Patents (Class 604/5.01)
  • Patent number: 10293102
    Abstract: Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, and two opposing longitudinal edge sections. The rigid body may include a controllable fluid pathway defined in part by the compliant membrane and extending from an inlet port to an outlet port. The pump cassette may include a piston disposed at least partially within the rigid body such that movement of the piston varies a volume of a pump chamber defined within the controllable fluid pathway.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: May 21, 2019
    Assignee: CareFusion 2200, Inc.
    Inventors: Corey Michael Magers, Daniel Toro, Daniel Abal, Santiago Roman Dodge, Robert Steven Vasko, Edward Browka
  • Patent number: 10085755
    Abstract: In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of an arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: October 2, 2018
    Assignee: DIAXAMED, LLC
    Inventors: James S. Johnson, Frank V. Patterson, Jordan Jacobs
  • Patent number: 9987412
    Abstract: An attachment assembly for attaching a fluid container to a fluid warmer of a system for extracorporeal blood treatment is disclosed. The assembly includes a hook-shaped fixture located on the fluid warmer, a pin-shaped fixture located on the fluid warmer, and receiving members located on the fluid container to receive the hook-shaped fixture and the pin shaped fixture located on the fluid warmer. A fluid warmer containing a hook-shaped fixture located on the fluid warmer and a pin-shaped fixture located on the fluid warmer of a fluid bag attachment assembly is also disclosed. Tubing guides present on the fluid warmer in conjunction with tubes of differing lengths attached to the fluid bag reduce the occurrence of usage errors during insertion of the fluid bag into the fluid warmer.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: June 5, 2018
    Assignee: B. BRAUN AVITUM AG
    Inventors: Joern Ahrens, Máté Bocz, Jean-Paul Menneguerre
  • Patent number: 9925324
    Abstract: The present invention relates to a reception means for receiving fluids, which comprises a fluid surge redirection element comprising at least one flow-conditioning body that is adapted and intended to divide the fluid surge of the inflowing fluid into at least two partial fluid surges. It further relates to an external functional means as well as a treatment apparatus comprising a reception means in accordance with the invention.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: March 27, 2018
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Martin Lauer, Goetz Guenther
  • Patent number: 9683013
    Abstract: The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilized to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the matrix containing the immunoglobulin containing proteins adsorbed thereon; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the Asparagine at the position corresponding to N28 of B domain of Protein A or Protein Z, and wherein the ligand provides an increase in elution pH compared to non-substituted ligand.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: June 20, 2017
    Assignee: GE HEALTHCARE BIOPROCESS R&D AB
    Inventors: Tomas Bjorkman, Elin Monie, Gustav Rodrigo
  • Patent number: 9656012
    Abstract: A method and a device for determining an operating parameter of a device for extracorporeal blood treatment as a function of absolute pressure include setting the absolute ambient pressure in a closed container filled partially with air and having an essentially constant container volume by equalization of pressure with respect to the surroundings, and the pressure is maintained by isolating the container. With delivery means, a predetermined sequence of strokes of a liquid is delivered into or out of the container, and the change in the relative container pressure is measured after each delivery stroke. The total volume delivered and the relative pressure are assigned to a value pair, and the absolute pressure and the initial air volume is determined based on the Boyle-Mariotte law by using the value pairs for at least two delivery strokes. The operating parameter is calculated and adjusted as a function of the absolute pressure.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: May 23, 2017
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Alfred Gagel
  • Patent number: 9597440
    Abstract: A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: March 21, 2017
    Assignee: MEDTRONIC, INC.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
  • Patent number: 9555183
    Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 31, 2017
    Assignee: OSPREY MEDICAL, INC.
    Inventor: David Martin Kaye
  • Patent number: 9539267
    Abstract: The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug, either alone, or in combination with immune therapeutics such as, for example, monoclonal antibodies that selectively bind B-cell specific antigens.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: January 10, 2017
    Assignee: The Johns Hopkins University
    Inventors: Robert A. Brodsky, Richard J. Jones, Richard F. Ambinder
  • Patent number: 9541544
    Abstract: A method for optimal selection of cytotoxic agents for organ or region specific therapy that includes extracorporeal filtration of the cytotoxic agent from blood drained from the organ or region being treated and return of the filtered blood to a mammal is disclosed.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 10, 2017
    Assignee: Delcath Systems, Inc.
    Inventors: Eamonn P. Hobbs, Daniel S. Johnston
  • Patent number: 9433719
    Abstract: A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: September 6, 2016
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Peter A. Hopping
  • Patent number: 9242035
    Abstract: A dialysis system comprising: a sorbent cartridge in fluid communication with at least one of a patient or a dialyzer, the sorbent cartridge including a housing having a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a storage container in fluid communication with the sorbent cartridge; a pump in fluid communication sorbent cartridge and the storage container; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction, reverse from the first direction, through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zircon
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 26, 2016
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Sujatha Karoor
  • Patent number: 9211372
    Abstract: A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: December 15, 2015
    Assignee: Osprey Medical, Inc.
    Inventor: David Martin Kaye
  • Patent number: 9192707
    Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: November 24, 2015
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, Manda R. VenKatesh, Bryant Pudil
  • Patent number: 9186450
    Abstract: A method and apparatus for priming an extracorporeal blood circuit, in which the patient end of an arterial line (79) is connected to a first discharge port (61), and the patient end of a venous line (87) is connected to a second discharge port (62). The two discharge ports are connected to a used dialysate line which connects a dialyzer (33) to a drain. The arterial and venous lines are filled with a priming fluid, while the air contained in the arterial and venous lines is evacuated partly through the first discharge port and partly through the second discharge port. Two check valves (65, 66) prevent flow from the used dialysate line towards the two discharge ports. The invention reduces the risk of errors on the part of an operator readying the priming configuration, as well as the risk of contamination of the extracorporeal circuit during the priming phase.
    Type: Grant
    Filed: August 10, 2013
    Date of Patent: November 17, 2015
    Assignee: Gambro Lundia AB
    Inventors: Massimo Fava, Mauro Suffritti, Alessandro Scaglione
  • Patent number: 9115708
    Abstract: Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to, urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices actuated using a control fluid, optionally delivered using detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: August 25, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Dirk A. van der Merwe, Michael J. Wilt
  • Patent number: 9101726
    Abstract: Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and/or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed closed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and/or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: August 11, 2015
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Yong Zhao
  • Patent number: 9050412
    Abstract: A dialysis apparatus includes a housing; a first electrical contact carried by the housing; a hydrogel material located within the housing; a second electrical contact connected to the hydrogel material, the hydrogel material located so as to be contacted by a liquid flowing through the housing; and wherein the hydrogel material expands as the material absorbs the liquid such that the second electrical contact is moved and eventually engage the first electrical contact.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: June 9, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Karl H. Cazzini
  • Patent number: 9028457
    Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: May 12, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Barry F. Hecker
  • Patent number: 9011687
    Abstract: A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 21, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Matthew Swift, Barry F. Hecker, Michael D. Leach
  • Patent number: 9005343
    Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 14, 2015
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Paul J. Vernucci
  • Patent number: 8992453
    Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: March 31, 2015
    Assignee: Marine Polymer Technologies, Inc.
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • Patent number: 8992454
    Abstract: Splitable-tip catheters are disclosed with bioresorbable adhesive to provide spatial separation of distal tip elements during use. The invention can be particularly useful in hemodialysis applications where it is desirable to separate blood extraction and return lumens. The adhesive facilitates insertion of the distal end of the catheter as an assembly, e.g., into a blood vessel using a single guidewire, while the bioresorbable nature of the adhesive allows the tip elements to separate in vivo.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: March 31, 2015
    Assignee: Bard Access Systems, Inc.
    Inventor: Paramjith Anand
  • Patent number: 8992463
    Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: March 31, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Michael E. Hogard, Donald D. Busby, Robert W. Childers, Yuanpang Samuel Ding, Katherine M. Holian, Mark E. Jablonski, Thomas D. Kelly, Ying-Cheng Lo, Shincy J. Maliekkal, Rodolfo G. Roger, Donald A. Smith, Atif M. Yardimci
  • Patent number: 8986239
    Abstract: A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 24, 2015
    Assignee: Haemonetics Corporation
    Inventor: Alec D. Bobroff
  • Publication number: 20150080782
    Abstract: An access disconnection system includes a venous line, an arterial line, a first electrode coupled to (i) the arterial line, (ii) a patient, or (iii) a cardiac catheter assembly; and a second electrode coupled to (i) the venous line, or (ii) the cardiac catheter assembly. The access disconnection system further includes electronic circuitry communicating electrically with the first second electrode to sense an electrical heartbeat signal generated by the patient. The electronic circuitry is configured to send a disconnection output indicative of a change in the electrical signal sufficient to expect that an access disconnection of the venous line has occurred.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Inventors: Rodolfo Roger, Robert Childers, Thomas D. Kelly
  • Patent number: 8981948
    Abstract: A connector clip for medical sensors, including a first main body having two main tip contacts in electrical contact with electrical wires connectable to an instrument and a second main body mounted on the first main body and movable with respect to the first main body between an open position and a closed position. Two auxiliary tip contacts and an electric/electronic circuit provided with two connecting leads each electrically connected to one of the two auxiliary tip contacts are positioned in first or second main body. When a disposable sensor tab is correctly located and clamped each of two contacts is in contact with one of the main tip contacts and one of the auxiliary tip contacts and the electric circuit is connected in parallel with an electrical circuit defined by the sensor.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: March 17, 2015
    Assignee: Gambro Lundia AB
    Inventors: Bo Olde, Eddie Nilsson, Derek White, Thierry Court, Eric Roussi
  • Patent number: 8979793
    Abstract: Methods and devices for performing percutaneous and surgical interventions. The devices comprising a tubular portion and retractable mechanism at the distal end of the tubular portion. The retractable mechanism prevents the device from pulling out of an anatomical structure during complex interventions, for example, when switching from an antegrade to a retrograde approach within a blood vessel, enables the use of a single sheath when declotting AV hemodialysis fistulas and can provide occlusion of blood flow during interventions and means of removal of debris or clot from the blood vessel.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: March 17, 2015
    Inventor: Lawrence Hofmann
  • Patent number: 8979787
    Abstract: This invention uses “targeted apheresis” to treat pregnant women who are at risk of developing eclampsia. “Targeted Apheresis” is a process whereby certain growth factor receptors (sFlt-1) circulating in the blood of a pregnant woman at risk of developing pre-eclampsia are selectively removed by passing the blood through a cartridge containing immobilized anti-sFlt-1 aptamers. The circulating sFlt-1 is bound out by the immobilized anti-sFlt-1 aptamers and the cleaned blood is returned to the patient. Removal of circulating sFlt-1 will diminish the risk of developing eclampsia during pregnancy.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: March 17, 2015
    Inventors: Henry John Smith, James Roger Smith
  • Patent number: 8951484
    Abstract: Candidate cells, such as circulating tumor cells (CTCs), present with blood are captured using a multiple stage device, having successive stages configured to deviate candidate cells out of the blood while slowing down the flow rates of the deviated resultant for easier capture of CTCs through progressive stages. The devices can include separation channel and deviation channels formed of micro-post patterns dimensioned to deviate different desired candidate cells for analysis.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: February 10, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Tommaso F. Bersano-Begey, Daniel F. Hayes
  • Patent number: 8945037
    Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump 4, a venous blood circuit 3, a dialysate introduction line L1, a dialysate discharge line L2, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2. A control device (11) estimates or measures the concentration of blood in a dilution channel section A. The control device (11) controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: February 3, 2015
    Assignee: Nikkiso Company Limited
    Inventors: Shinya Hasegawa, Masahiro Toyoda
  • Patent number: 8932469
    Abstract: A dialysis machine includes a blood circuit, a dialysate circuit, and a dialyzer placed in communication with the blood circuit and the dialysate circuit. The dialysis machine includes a priming sequence in which dialysate is used to prime a first portion of the dialysate circuit and a physiologically compatible solution, other than dialysate, is used to prime a second portion of the dialysate circuit, the dialyzer and the blood circuit.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: January 13, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8926541
    Abstract: This invention relates to a means of clearing out a cholesterol, calcium and plaque build-up resident to a living circulatory system, in addition to dissolving various kinds of blood clots, and removing other foreign matter, all by means of charged particle migration, through the application of an electromotive source.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: January 6, 2015
    Inventor: Gary O. Sandstedt
  • Patent number: 8926540
    Abstract: A hemodialysis system includes (i) a dialyzer; (ii) a blood pump; (iii) a blood cassette operatively connected to the dialyzer and the blood pump; (iv) a dialysate heater; (v) first and second peristaltic dialysate pumps; and (vi) a dialysate cassette separate from the blood cassette, the dialysate cassette including an organizer configured to support a drain tube, a to-dialyzer tube and a from-dialyzer tube, the cassette further including a first pumping tube, a second pumping tube and an inline fluid heating pathway, the cassette when mounted for operation orienting (a) the first pumping tube for operation with the first peristaltic dialysate pump, (b) the second pumping tube for operation with the second peristaltic dialysate pump and (c) the fluid heating pathway for operation with the dialysate heater.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: January 6, 2015
    Assignees: Baxter Healthcare Inc., Baxter Healthcare S.A.
    Inventors: Ying-Cheng Lo, Robert W. Childers, Thomas D. Kelly, Justin Rohde
  • Patent number: 8926542
    Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: January 6, 2015
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, John Burnes, SuPing Lyu, VenKatesh R. Manda, Byant Pudil
  • Patent number: 8924458
    Abstract: This patent application relates generally to processing devices in the medical device area.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: December 30, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Roland Levin, Martin Joseph Crnkovich, Fei Wang, Michael Emmanuel Kotsos, Gregg Eric Fuhriman
  • Patent number: 8915875
    Abstract: The invention relates to a device and a method for depletion of hepcidin from blood for treatment of iron deficiency, in particular in anemic patients suffering from chronic renal failure, with the goal of increasing the availability of iron in the body and thus improving the treatment of the anemia. The hepcidin adsorbent comprises a matrix and a hepcidin-binding ligand covalently bonded to the matrix with an affinity having a dissociation constant KD of less than 200 nM.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: December 23, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Jutta Passlick-Deetjen, Wolfgang Hofmann
  • Patent number: 8911390
    Abstract: The present invention concerns a multipart fluid system for use in CRRT, wherein the multipart fluid system comprises an anticoagulation fluid and at least one fluid from the group consisting of a dialysis fluid and an infusion fluid. According to the invention the anticoagulation fluid comprises at least 8 mM citrate, and the dialysis fluid and/or infusion fluid comprises 2-8 mM citrate and 1-5 mM total calcium. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: December 16, 2014
    Assignee: Gambro Lundia AB
    Inventor: Jan Sternby
  • Patent number: 8900173
    Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump (4), a venous blood circuit (3), a dialysis fluid introduction line (L1), a dialysis fluid discharge line (L2), a dialysate infusing line (L8), and a dialysate infusing pump (13). A closed circuit is formed in the flow route of the dialysis fluid on the dialysis fluid introduction line (L1) side including a predetermined part where a collection port (11) is formed. A testing process is performed to confirm the connection of the dialysate infusing line (L8) to the collection port (11) by measuring fluid pressure within the closed circuit while driving the dialysate infusing pump (13).
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: December 2, 2014
    Assignee: Nikkiso Company Limited
    Inventor: Akira Sugioka
  • Patent number: 8889004
    Abstract: This disclosure generally relates to dialysis systems and related methods. In one aspect of the invention, a dialysis system includes a device configured so that a medical fluid can pass therethrough, and the device is adapted to remove one or more substances from the medical fluid as the medical fluid passes through the device. The dialysis system can also include a sodium control system adapted to alter a sodium concentration of the medical fluid.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: November 18, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Palmer David Updyke, Harold Frederick Sandford, Benjamin Joseph Lipps, Douglas Mark Zatezalo, Michael James Beiriger, James Matthew Mullner
  • Patent number: 8881600
    Abstract: In a process for testing filters (4) and (13) of treatment fluid of a hemodiafiltration apparatus (1), each filter has a wet semipermeable membrane (5, 14) which separates a gas-filled first chamber (6 and 15) from a liquid-filled second chamber (7 and 16). The first chambers are pressurised by a pump (19) supplying air, while the second chambers are placed in depression by a drainage pump (17) of used dialysis fluid. A first closed system is formed which includes the first chambers and a second closed system is formed which includes the second chambers. Two pressure gauges (P1 and P2) monitor the pressure in the two closed systems for a predetermined time. The monitoring provides indications relating to the filter integrity.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: November 11, 2014
    Assignee: Gambro Lundia AB
    Inventors: Anna Puppini, Renato Pedrazzi, Mauro Suffritti
  • Patent number: 8882692
    Abstract: A hemodialysis system for operation with a blood source and a dialysate source, the system including: (i) a first machine portion including a blood pump; (ii) a blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette when the blood cassette is in fluid communication with the blood source; (iii) a dialyzer fluidly connected to the blood cassette; (iv) a second machine portion separate from the first machine portion, the second machine portion including a dialysate pump; and (v) a dialysate cassette separate from the blood cassette, the dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette being fluidly connected to the dialyzer.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: November 11, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Ying-Cheng Lo, Robert W. Childers, Thomas D. Kelly, Justin Rohde
  • Patent number: 8877062
    Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: November 4, 2014
    Assignee: Interface Biologics, Inc.
    Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark Steedman, Roseita Esfand
  • Patent number: 8877177
    Abstract: An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: November 4, 2014
    Assignee: ITH Immune Therapy Holdings AB
    Inventors: Ola Winqvist, Graham Cotton
  • Publication number: 20140323942
    Abstract: The described system and method for blood treatment are configured to detect at least two hemodynamic parameters, for example the blood pressure and the relative blood volume, during the blood treatment. At least two fuzzy modules receive measuring values of the hemodynamic parameters as input variables, wherein the output signals transmitted by the fuzzy modules are weighted by at least one weighting module. A setting means effectuates setting of at least one variable, for example an ultrafiltration rate, a dialysis fluid conductivity or a dialysis fluid temperature, in response to the output signal transmitted by the weighting module. In this way, e.g. threatening intradialytic hypotensive episodes can be detected and avoided. The system can be designed as a dialyser for hemodialysis, hemofiltration or hemodiafiltration.
    Type: Application
    Filed: February 26, 2014
    Publication date: October 30, 2014
    Applicant: B. BRAUN AVITUM AG
    Inventors: Richard Atallah, Christof Strohhoefer, Juergen Wagner
  • Patent number: 8864700
    Abstract: A plurality of heat transfer pipes have a circumferential portion arranged at a short distance from an inner surface of a heat exchanger case while they are bundled to form a pipe group and a first chord which retracts toward a center in a direction of cylinder diameter from an arc formed by the circumferential portion. The plurality of bundled heat transfer pipes are loaded in the exchange case such that the first chord and an inner surface of the heat exchange case on a side where a heat exchange medium inlet port is attached are opposed to each other. By making a flow of a heat exchange medium to each heat transfer pipe uniform, a heat exchanger capable of obtaining high heat exchange performance is obtained.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: October 21, 2014
    Assignee: Nipro Corporation
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Patent number: 8868350
    Abstract: A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: October 21, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Alp Akonur, John Kenneth Leypoldt, Ying-Cheng Lo, Baris Ugur Agar
  • Patent number: 8865172
    Abstract: A method for reducing the number of selected antibodies in a subject's blood, the method comprising removing blood from the subject, passing the blood along an enclosed pathway, wherein the pathway comprises one or more semi-permeable hollow fibers with one or more membranes having surfaces positioned substantially perpendicular to the length of the one or more hollow fiber and antigens specific for the antibodies immobilized on the one or more membranes, returning the treated blood to the internal circulation of the subject, wherein the returned treated blood has a reduced number of selected antibodies compared to before treatment.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: October 21, 2014
    Assignee: Advanced Extravascular Systems, Inc.
    Inventor: Duke K. Bristow
  • Patent number: 8852135
    Abstract: A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: October 7, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Josef Beden, Itka Bado, Georg Verch
  • Patent number: 8852140
    Abstract: Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: October 7, 2014
    Assignee: Fenwal, Inc.
    Inventors: John W. Barry, Jr., Brian C. Case, Lan T. Nguyen