Blood Drawn And Replaced Or Treated And Returned To Body Patents (Class 604/4.01)
  • Patent number: 11219709
    Abstract: According to some embodiments, a system may treat blood containing metformin outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 4 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: January 11, 2022
    Assignee: HUMANITY LIFE EXTENSION LLC
    Inventors: Patrick Richard Spearman, Shelly Amann
  • Patent number: 11207451
    Abstract: An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid (16, 20, 21, 26) and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: December 28, 2021
    Assignee: Gambro Lundia AB
    Inventors: Hiram Rada, Dominique Pouchoulin, Georges Vantard, Alain Frugier
  • Patent number: 11181132
    Abstract: Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 23, 2021
    Assignee: Vivonics, Inc.
    Inventors: Anna Galea, Joseph Beuford Parse, Kylie Stengel, Kristen LeRoy, Minh Duong, Samuel Harrington Warner, Andrew Evan Kamholz, Brandon Johnson
  • Patent number: 11160908
    Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 2, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Jeffrey Olson
  • Patent number: 11123468
    Abstract: A filtering device receives a pressure signal (P) from a pressure sensor in a fluid containing system, the pressure signal (P) comprising first pulses originating from a first periodic pulse generator and second pulses. The device acquires a reference signal which is indicative of a current operating frequency of the first periodic pulse generator. The device identifies, based on the reference signal, a plurality of harmonics (v1-v8) associated with the current operating frequency, computes correlation values (?1-?8) between the harmonics and the pressure signal (P) within a time window in the pressure signal (P), and generates a filtered signal by subtracting, as a function of the correlation values (?1-?8), the harmonics from the pressure signal (P). The use of correlation values is a direct, fast, robust and computation-efficient approach for estimating the signal contribution (d) from first pulses in the pressure signal (P).
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: September 21, 2021
    Assignee: Gambro Lundia AB
    Inventors: Kristian Solem, Bo Olde, Jan Sternby
  • Patent number: 11083828
    Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysis fluid circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for determining or receiving a proposed value (Condprop) of a conductivity for the dialysis fluid in the dialysis supply line (8) and to determine a set value (Condset) for the conductivity in the dialysis fluid as a function of the proposed value (Condprop) and as a function of at least one of a second parameter (UF volume/W; WL/W) indicative of a patient fluid overload and a third parameter (gconc) chosen in the group including: a glucose concentration in the patient and a concentration-related parameter of at least glucose in the patient.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: August 10, 2021
    Assignee: GAMBRO LUNDIA AB
    Inventor: Jan Sternby
  • Patent number: 11045300
    Abstract: Systems, devices, and methods for organ Retroperfusion along with regional mild hypothermia. One such system includes a hypothermia system including a hypothermia system outlet and a hypothermia system inlet; and a connector comprising a coolant inlet, a coolant outlet, a coolant reservoir, and a blood lumen, whereby the coolant inlet is configured to couple to the hypothermia system outlet and whereby the coolant outlet is configured to couple to the hypothermia system inlet; whereby a cooling product, when the hypothermia system is connected to the connector, can flow from the hypothermia system, through the hypothermia system outlet, into the coolant inlet, through the coolant reservoir, into the coolant outlet, and into the hypothermia system inlet, so that the cooling product can cool blood flowing through the blood lumen.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: June 29, 2021
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr., Zachary Berwick
  • Patent number: 11045595
    Abstract: A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: June 29, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
  • Patent number: 10994074
    Abstract: A pump for infusing fluid, the pump including a pumping mechanism, a fluid delivery device, a plurality of electric field sensors, and a measurement component. The plurality of electric field sensors is configured to estimate either an electric field that is associated with a patient, or an electric field that is associated with a fluid path of the pump, or both. The measurement component is configured to receive the electric field estimates from each of the electric field sensors and further configured to measure the difference between the electric field estimates.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 4, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: David Blumberg, Jr., Michael F. Bellino
  • Patent number: 10993808
    Abstract: Delivery devices and device elements that provide steering capabilities and methods of steering such delivery devices during the delivery of a stented prosthesis to a target site. Various delivery devices include a shaft assembly having a plurality of lumens through which tension members that compressively retain the stented prosthesis to the shaft assembly are routed. By selectively tensioning one or more tension members, the shaft assembly can be pulled or steered in a desired direction. Various embodiments include one or more steering or stiffening rods that can reinforce the device or counteract any unintended bending or steering of the delivery device.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: May 4, 2021
    Assignee: Medtronic, Inc.
    Inventors: Michael Gloss, James R. Keogh, Timothy Ryan, Declan P. Costello, Wayne M. Falk
  • Patent number: 10864311
    Abstract: A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UFD) as a volume withdrawal on the basis of a pressure difference (?P) and a temperature difference (?T) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UDF) is calculated using the pressure difference (?P) established on the basis of fluid pressure values determined by the pressure sensors, and the temperature difference (?T) established on the basis of temperature values determined by the temperature sensors.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 15, 2020
    Assignee: B. BRAUN AVITUM AG
    Inventor: André Wagner
  • Patent number: 10835868
    Abstract: A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36).
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 17, 2020
    Assignee: GAMBRO LUNDIA AB
    Inventors: Olof Jansson, Björn Ericson
  • Patent number: 10828413
    Abstract: A system and method for the practice of apheresis employs modules in the system which can be selected for a particular patient to treat particular situations or combinations of difficulties. In one example, Gal-3 mediates a large number of body reactions, and is an effective protector of tumor microenvironments and the like, as well inflammation driver. Removal of Gal-3 may make antic-cancer treatments, like photopheresis and TNF administration more effective. Separate modules, such as one for photopheresis and one for TNF receptor removal, may be combined with a module for the reduction of Gal-3, to render the combination of treatments each more effective than if administered alone.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: November 10, 2020
    Assignee: ELIAZ THERAPEUTICS, INC.
    Inventor: Isaac Eliaz
  • Patent number: 10792415
    Abstract: A failsafe system for a medical fluid procedure, comprising a medical fluid processing apparatus comprising a sealer and a programmable controller driven by software, wherein the programmable controller is programmed to recognize a failure event from input from hardware components of the medical fluid processing apparatus. The system also comprises a disposable fluid circuit configured to associate with the medical fluid processing apparatus and comprising a tubing segment configured to fit within the sealer. The programmable controller is configured to seal the tubing segment by activating the sealer surrounding the tubing segment in response to an occurrence of the failure event.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: October 6, 2020
    Assignee: Fenwal, Inc.
    Inventor: James Darren Roxas
  • Patent number: 10722636
    Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: July 28, 2020
    Assignee: MEDTRONIC, INC.
    Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
  • Patent number: 10702643
    Abstract: For regulating and presetting the pump rate of a blood pump, a device and a method are configured for monitoring blood pressure values upstream and/or downstream from the blood pump. The monitored values, or another value formed from the monitored values, are compared with a limit value, which depends on an operating parameter or a pump parameter of the blood pump. In violation of the limit value, the pump rate of the blood pump is modified to such an extent, or a new pump rate is determined, such that the limit value is no longer violated or the degree of violation is reduced.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: July 7, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christoph Wiktor, Arne Peters, Alexander Heide, Manfred Weis
  • Patent number: 10625013
    Abstract: A monitoring device is operated to detect a disruption of a fluid connection between two fluid containing systems. A disruption detector in the monitoring device operates on a measurement signal (Pi) to detect an apparent disruption of the fluid connection and generate a corresponding alarm indication. The monitoring device is configured to optimize the configuration of the disruption detector to limit the number of false alarms, by operating a false alarm analyzer to produce a count (FA #) of false alarm indications generated per unit time by the disruption detector for one or more configurations (?L) of the disruption detector, and by operating an updater to update the configuration (?L) of the disruption detector based on the count (FA #). The monitoring device may be connected to or part of an apparatus for blood treatment and operable to detect a disconnection of an extracorporeal blood circuit from a vascular system of a patient, e.g. a venous-side disconnection.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: April 21, 2020
    Assignee: GAMBRO LUNDIA AB
    Inventor: Jan Sternby
  • Patent number: 10596315
    Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: March 24, 2020
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Richard G. Patton, Shan E. Gaw
  • Patent number: 10551803
    Abstract: The present invention relates to a method of adapting of a second threshold window of at least a second measured variable depending on the change of a first threshold window of a first measured variable, wherein the adaptation is performed by the use of a control unit having been provided and/or configured therefor. The present invention further relates to a control device, a medical treatment apparatus, a medical monitoring apparatus, a digital storage means, a computer program product and a computer program.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 4, 2020
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Martin Gruendken, Uwe Herrmann, Sabine Kipp, Christine Nachbaur-Sturm, Thomas Pusinelli
  • Patent number: 10463778
    Abstract: A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: November 5, 2019
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Rodolfo Roger, Robert Childers, Thomas D. Kelly
  • Patent number: 10441703
    Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 15, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
  • Patent number: 10385312
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: August 20, 2019
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Patent number: 10350344
    Abstract: The invention relates to a method of monitoring an extracorporeal blood treatment apparatus having an extracorporeal blood circuit and in particular a venous needle disconnection by means of pressure pulse measurement at the extracorporeal blood circuit. The invention further relates to an apparatus for carrying out a monitoring method and to a blood treatment apparatus which includes a corresponding monitoring apparatus.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: July 16, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christoph Wiktor, Alexander Heide, Arne Peters
  • Patent number: 10322219
    Abstract: The present invention relates to a method of determining the pressure or of a parameter correlated with the pressure in an extracorporeal circuit of a blood treatment apparatus, in particular of a dialyzer, wherein at least one blood pump which is driven by at least one motor is located in the blood circuit, wherein the motor current of the named motor and the blood flow or a parameter correlated therewith is measured for determining the pressure or the parameter correlated therewith and wherein the pressure p or the parameter correlated therewith is calculated from the measured values.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: June 18, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Alfred Gagel, Benedict Glaser, Haitham Ibrahim, Pascal Kopperschmidt
  • Patent number: 10273456
    Abstract: Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 30, 2019
    Assignee: FENWAL, INC.
    Inventors: Katherine Radwanski, Kyungyoon Min
  • Patent number: 10213462
    Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis, comprising at least in part donor apheresis, using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: February 26, 2019
    Assignee: ELIAZ THERAPEUTICS, INC.
    Inventor: Isaac Eliaz
  • Patent number: 10195332
    Abstract: A renal therapy blood cleansing system is provided. The renal therapy blood cleansing system includes a blood circuit including a blood filtering device, a therapy fluid circuit including a balance chamber configured to exchange like volumes of fresh and used therapy fluid, a first pump configured to pump fresh therapy fluid to the balance chamber, a second pump configured to pump used therapy fluid to the balance chamber, and at least one valve located downstream from the balance chamber, the at least one valve enabling fresh therapy fluid from the balance chamber to be directed selectively to (i) a flow path leading to an inlet of the blood filtering device, or (ii) a flow path leading to the blood circuit at a location upstream or downstream of the blood filtering device.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: February 5, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Thomas D. Kelly, Waleed M. El Sayyid
  • Patent number: 10179199
    Abstract: A medical apparatus for extracorporeal blood treatment and a method for determining blood parameter value have been provided. The medical apparatus has a control unit (9) configured for taking from a storage memory (10) a plurality of blood parameter value measures each made through the sensors (8) provided on the bloodline set of each of a machines plurality at different patient treatment sessions; all the blood parameter values relate to the same patient; receiving at least a corresponding laboratory measured valise of the same blood parameter relating to the same patient and a laboratory measurement time; determining a correction factor function of a difference between a measured value made though the sensor and a laboratory measured value; obtaining an actual value of said blood parameter by varying at least the last measure made through the sensor by means of the correcting factor.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 15, 2019
    Assignee: Gambro Lundia AB
    Inventor: Bernard Bene
  • Patent number: 10166364
    Abstract: Systems and methods for manufacturing a peripheral catheter having a plurality of diffusion holes.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: January 1, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Chad M. Adams, Jonathan Karl Burkholz, Austin Jason McKinnon
  • Patent number: 10076598
    Abstract: An automated peritoneal dialysis therapy device includes pump tubing for delivering dialysate to a patient and for removing waste from the patient; a retractable peristaltic pump assembly; and a processor for controlling operations of the automated peritoneal dialysis therapy device. The retractable peristaltic pump assembly includes a retractable peristaltic pump having a pump rotor and a pump base, a heating source, located in the pump base, to heat the dialysate, a first temperature sensor to measure a temperature of the heating source, a second temperature sensor to measure a temperature of the dialysate, a flow sensor to measure an amount of dialysate being pumped, a pressure sensor to measure a pressure of the dialysate being pumped, and a motor to rotate the pump rotor. The processor controls rotational speed, displacement, and a direction of the pump rotor.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: September 18, 2018
    Inventor: James Dean Lattimore
  • Patent number: 10022485
    Abstract: A device and method for monitoring an access to a patient, an extracorporeal blood circuit and/or a dialyzing fluid system includes a centrifugal pump for conveying blood or dialyzing fluid instead of an occluding pump. Centrifugal pumps bring about a large change in flow rate by even a small change in pressure difference across the pump. The device includes a measuring unit for measuring the flow rate of blood or dialyzing fluid conveyed by the centrifugal pump, and a control and computing unit configured to determine an incorrect vascular access or malfunction if a change in measured flow rate Q is more than a predetermined amount. For example, a small drop in pressure in the venous blood line leads to a marked increase in the flow rate of the centrifugal pump, which is used as a basis for the detection of an incorrect vascular access.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: July 17, 2018
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Arne Peters, Christoph Wiktor
  • Patent number: 10016549
    Abstract: A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: July 10, 2018
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Christine Vivian Stonger, Palmer David Updyke, John Arrizza, Michelle Bayly, Phil Swenson, DaVeeda Callie Mason, Edward Royal, Gaudencio D. Barredo, Jr., Sandra S. Gadeyne
  • Patent number: 10004838
    Abstract: A reserve zirconium phosphate module for continuing dialysis in the event the capacity of the original zirconium phosphate module is exceeded. The sorbent cartridge can have a sensor for detecting when the capacity of the zirconium phosphate material has been exceeded, and a valve assembly for diverting the flow of spent dialysate into the reserve module when needed. Any of the modules of the sorbent cartridge can be reusable and the sorbent materials therein recharged.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: June 26, 2018
    Assignee: MEDTRONIC, INC.
    Inventors: Martin T. Gerber, Christopher M. Hobot
  • Patent number: 10004874
    Abstract: A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: June 26, 2018
    Assignee: Nirva Medical, LLC
    Inventor: Pramote Hochareon
  • Patent number: 9936923
    Abstract: Systems and methods are disclosed for monitoring data associated with a plurality of physiological characteristics of a patient, comprising: the methods include generating a set of super-alarm patterns associated with the plurality of physiological conditions, wherein the super-alarm patterns comprising data relating to a combination of at least two individual raw alarms from independent physiological data streams that co-occur within a temporal window, and triggering an alarm if a combination of the input physiological data matches at least a portion of a generated super-alarm pattern.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: April 10, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Xiao Hu, Neil A. Martin
  • Patent number: 9925315
    Abstract: Peristaltic pump assemblies in which the closing and opening of a pivoting or sliding door is coordinated with movement of the occlusion bed toward and away from the rotor assembly to engage and disengage tubing within the occlusion pathway are disclosed. Linkage mechanisms provided by the interaction of cam surfaces with rollers, as well as bar linkage mechanisms, are disclosed. The linkage mechanism, in addition to providing precise displacement of the occlusion bed, may also provide an over-center feature that enhances safety and pump operation when the door is in a closed position. Latching mechanisms and sensors may be incorporated. Control consoles incorporating such peristaltic pump assemblies are described. Adaptive components such as tubing cassettes routing aspiration and/or infusion tubing in a predetermined configuration to mate with occlusion pathways in aspiration and/or infusion pump assemblies provided in various types of medical devices and control consoles are also provided.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: March 27, 2018
    Assignee: BOSTON SCIENTIFIC LIMITED
    Inventors: Shannon Eubanks, Keith Schubert, Peter Bristol, Patrick Vilbrandt
  • Patent number: 9922401
    Abstract: Provided is an image processing device for performing noise removal in which a plurality of noise removal actions are combined while minimizing necessary resources.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: March 20, 2018
    Assignee: NEC CORPORATION
    Inventors: Eita Kobayashi, Takashi Takenaka
  • Patent number: 9878082
    Abstract: The invention relates to a method and apparatus for optimizing an extracorporeal blood treatment using an extracorporeal blood treatment apparatus, an extracorporeal blood treatment apparatus with a device for optimizing the extracorporeal blood treatment, and a computer program to be executed on a processor for carrying out a method for optimizing the extracorporeal blood treatment. The method and apparatus are characterized in that at least one machine-specific treatment parameter for carrying out the treatment using the respective dialyzer or filter is determined with a computing unit for different types of dialyzers or filters. The computing unit determines the costs resulting from the determined machine-specific treatment parameters when using the respective dialyzer or filter. The determined costs for different types of dialyzers or filters are then displayed on a display unit. The doctor can then select the dialyzer or filter to keep the costs as low as possible.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: January 30, 2018
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Peter Hilgers, Joerg Telcher
  • Patent number: 9878087
    Abstract: The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system. The pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to the blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein the body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: January 30, 2018
    Assignee: TC1 LLC
    Inventors: J. Scott Richardson, Barry N. Gellman, Andrew Koert, Kurt Dasse
  • Patent number: 9872645
    Abstract: The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: January 23, 2018
    Assignee: Magnolia Medical Technologies, Inc.
    Inventor: Richard G. Patton
  • Patent number: 9750864
    Abstract: The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyzer or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyzer or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyzer or filter.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: September 5, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Pascal Kopperschimdt
  • Patent number: 9717840
    Abstract: One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: August 1, 2017
    Assignee: NXSTAGE MEDICAL, INC.
    Inventors: Jeffrey H. Burbank, James M. Brugger
  • Patent number: 9675745
    Abstract: A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (“UF”) volume over a treatment; a graphical user interface (“GUI”) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 13, 2017
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • Patent number: 9662118
    Abstract: One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 30, 2017
    Assignee: Silk Road Medical, Inc.
    Inventor: David W. Chang
  • Patent number: 9574925
    Abstract: A fluid measurement device includes a circuit unit into which a first signal output from a first detection element and a second signal output from a second detection element are input. The circuit unit includes a signal processing part, a state deciding part, and a controller. The controller controls an amount of change that a change of the first signal imparts to the third signal in accordance with a result of decision by the state deciding part that determines that the state of the first signal is not within the predetermined range. The predetermined range is based on the second signal.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: February 21, 2017
    Assignee: Hitachi Automotive Systems, Ltd.
    Inventors: Satoshi Asano, Masahiro Matsumoto, Hiroshi Nakano, Keiji Hanzawa
  • Patent number: 9554735
    Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 31, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Mihailo V. Rebec, James E. Smous, Steven D. Brown, Hu-Wei Tan
  • Patent number: 9492602
    Abstract: Concentrate for a dialysis liquid, at least comprising one acid and one physiologically acceptable electrolyte, characterized in that the acid comprises at least one acidic ion exchanger or is an acidic ion exchanger.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: November 15, 2016
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Andreas Terpin, Volker Nier
  • Patent number: 9486567
    Abstract: The present invention relates to a method for assessing a patient's sensitivity to fluid removal from the patient's vascular system or to fluid replacement or addition with regard to the patient's hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfills at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage device, a computer program product, and a computer program.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: November 8, 2016
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Paul Chamney, Ulrich Moissl, Peter Wabel, Volker Nier, Sebastian Wieskotten
  • Patent number: 9402945
    Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 2, 2016
    Assignee: OUTSET MEDICAL, INC.
    Inventors: Michael Edward Hogard, Gopi Lingam, Dean Hu, Balaji M. Maniam, James Ritson, Andy H. Uchida, John David Stienmier, Paul David McGregor
  • Patent number: 9364598
    Abstract: The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyzer or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyzer or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyzer or filter.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: June 14, 2016
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Pascal Kopperschmidt