Blood Drawn And Replaced Or Treated And Returned To Body Patents (Class 604/4.01)
  • Patent number: 11925743
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: March 12, 2024
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas J. Felt, Dennis J. Hlavinka, Brian M. Holmes
  • Patent number: 11905311
    Abstract: A system and method for producing high levels of autologous IL-1RA cytokine, includes a blood collection vessel, a cover, a portion of separation gel, an anticoagulant portion, a plasma collection syringe comprising a sharp needle, a buffy coat collection syringe and an incubation tube with cover. The blood collection vessel is adapted such that when containing whole blood and being centrifuged, after treatment yields separation fractions comprising, a first fraction of RBCs sediment, a second fraction of said gel, a third fraction comprising WBCs, platelets and a fourth fraction of plasma solution.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: February 20, 2024
    Assignee: ESTAR TECHNOLOGIES LTD
    Inventor: Aaron Esteron
  • Patent number: 11896246
    Abstract: A system for removing an undesirable material from within a vessel is provided. The system includes a cannula designed for maneuvering within a blood vessel to a site of interest and applying a suction force, such that the undesirable material can be captured and removed along the cannula away from the site. The system also may include a catheter having a balloon at its distal end. The balloon may be designed to be positioned adjacent to the undesirable material such that the undesirable material is situated between the balloon and the cannula. The catheter may also be designed to subsequently impart a force onto the undesirable material for removal of the undesirable material. A method for removing an undesirable material from within a vessel is also provided.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 13, 2024
    Assignee: AngioDynamics, Inc.
    Inventors: Lishan Aklog, Michael Glennon
  • Patent number: 11890403
    Abstract: A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: February 6, 2024
    Assignee: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, Michael J. Wilt, Brian D. Tracey, Brett A. Rudolf, David E. Collins, Lisa A. Gustin, James D. Dale, Jesse T. Bodwell
  • Patent number: 11890452
    Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: February 6, 2024
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Richard G. Patton, Shan E. Gaw
  • Patent number: 11878097
    Abstract: The availability of a heart-lung machine in a box provides an opportunity for saving lives in emergency situations arising outside a hospital and for more cost effective care in hospital settings.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: January 23, 2024
    Inventor: Arnold J. Lande
  • Patent number: 11813387
    Abstract: A flow path is formed in a cassette body of a blood component collection cassette. The cassette body includes a bulging structure in which at least a portion of the flow path is formed. A first gripped member, which is configured to be gripped by a first gripping member provided on a centrifugal separation device, is disposed on one surface of the bulging structure in a thickness direction thereof. A second gripped member, which is configured to be gripped by a second gripping member to which a load detection unit that is provided on the centrifugal separation device is fixed, is disposed on another surface of the bulging structure in the thickness direction thereof.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: November 14, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Masatsugu Igarashi
  • Patent number: 11814430
    Abstract: The invention provides means, methods, and compositions of matter useful for enhancing tumor response to checkpoint inhibitors. In one embodiment, the invention teaches utilization of extracorporeal apheresis, specifically removal of various tumor derived, or tumor microenvironment derived immunological “blocking factors”. In one embodiment the invention provides the removal of soluble TNF-alpha receptors (sTNF-Rs) as a means of augmenting efficacy of immune checkpoint inhibitors. In one specific embodiment removal of sTNF-Rs is utilized to enhance efficacy of inhibitors of the PD-1/PD-L1 pathway, and/or the CD28/CTLA-4 pathway.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: November 14, 2023
    Assignee: IMMUNICOM, INC.
    Inventors: Thomas Emanuel Ichim, Steven Francis Josephs, Stephen Michael Prince, Amir Jafri, Robert Segal, David L. Schlotterbeck
  • Patent number: 11786720
    Abstract: A catheter pump assembly is provided that includes an elongate body, an elongate flexible shaft disposed in the elongate body, and an impeller coupled with the distal end of the elongate flexible shaft. The drive system includes a drive component, a motor and a tension member. The tension member is coupled with the motor and the drive component and to cause the drive component to rotate, and thereby to cause the impeller to rotate.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: October 17, 2023
    Assignee: TC1 LLC
    Inventor: Paul F. Muller
  • Patent number: 11738133
    Abstract: Features for protecting against leaks in a fluid circuit are disclosed. In an embodiment, a first indicator of a leak is used to trigger confirmation by blood flow reversal and air detection in the blood circuit. A method for performing a blood treatment includes, at blood treatment machine, pumping blood to a patient through a first blood line. Further, at a controller of the blood treatment machine, a first signal is received, indicating a probability of a leak in the first blood line. Responsively to the first signal, the controller commands a leak verification operation and receives a second signal indicating whether a leak in the first blood line is verified. Further, a leak indicating signal is generated if the second signal indicates a leak is verified.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 29, 2023
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, James M. Brugger, Daniel Joseph Rubery, Jr.
  • Patent number: 11732003
    Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: August 22, 2023
    Assignee: EMD Millipore Corporation
    Inventors: Ronald Tuccelli, John Caulmare, Luc Messier, Melissa Holstein, Christopher Gillespie, Roger Hill
  • Patent number: 11690942
    Abstract: A blood purification apparatus that is capable of, with no preparatory operations, performing substitution by supplying dialysate in a dialysate introduction line to a blood circuit during ultrafiltration treatment, or performing blood return by immediately supplying the dialysate in the dialysate introduction line to the blood circuit after the ultrafiltration treatment. A blood purification apparatus includes a dialyzer, a dialysate introduction line, a dialysate drain line L2 through which drain liquid from the dialyzer is drained, and an ultrafiltration pump capable of removing water from the blood in the blood circuit. The blood purification apparatus is capable of performing substitution or blood return by supplying the dialysate in the dialysate introduction line L1 to the blood circuit.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: July 4, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Takeshi Ichikawa, Satoshi Takeuchi
  • Patent number: 11607225
    Abstract: Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system can be configured to provide an estimation of the cumulative effects of the treatment. For example, some embodiments of the system or method can treat myocardium that is at risk of infarction by intermittently altering blood flow in a venous system to induce microcirculation within the myocardium, and can output a cumulative dosage value indicative of a measurement of progress of reducing an infarct size.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: March 21, 2023
    Assignee: Miracor Medical SA
    Inventors: Lars Roman Schiemanck, Martin Haidacher
  • Patent number: 11596411
    Abstract: Systems and methods for partial aortic occlusion are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient, and a catheter controller unit that causes the device to expand and contract to restrict blood flow through the aorta. The system also may include sensors for measuring blood pressure distal and proximal to the expandable device.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: March 7, 2023
    Assignees: The Regents of the University of California, Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Michael Austin Johnson, Timothy K. Williams, Lucas Paul Neff
  • Patent number: 11529463
    Abstract: An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises a perfusion chamber (16) containing a load of biologically active cells and is provided with a fluid entrance (18), a fluid exit (20) and a chamber volume (22) formed therebetween. The fluid entrance comprises at least one first microchannel platelet (24) and the fluid exit comprises at least one second microchannel platelet (26), each one of the microchannel platelets comprising at least one array of microchannels (28) defining a fluid passage between respective external and internal platelet faces, the microchannels having an opening of 0.2 to 10 ?m.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 20, 2022
    Assignee: SERAIP AG
    Inventor: Carlo Andretta
  • Patent number: 11511104
    Abstract: The invention generally relates to improved medical blood pump devices, systems, and methods. For example, blood pumps may be provided that include a housing defining a blood flow path between an inlet and an outlet. A rotor may be positioned in the blood flow path. A motor stator may be driven to rotate the rotor to provide the blood flow through the pump. Axial and/or tilt stabilization components may be provided to increase an axial and/or tilt stabilization of the rotor within the blood flow path. In some embodiments, biasing forces are provided that urge the rotor toward a bearing component. The biasing force may be provided by adjusting drive signals of the motor stator. Additionally, or alternatively, one or more magnets (e.g., permanent/stator magnets) may be provided to bias the rotor in the upstream and/or downstream direction (e.g., toward a bearing (chamfer, step, conical), or the like).
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: November 29, 2022
    Assignee: TC1 LLC
    Inventors: Onur Dur, Kevin Bourque
  • Patent number: 11511029
    Abstract: An extracorporeal blood treatment apparatus comprises: a blood treatment device (2); an extracorporeal blood circuit comprising a blood withdrawal line (6) and a blood return line (7) coupled to the extracorporeal blood treatment device (2), wherein the blood return line (7) presents a heating zone (14) coupled or configured to be coupled to a blood warmer (15); a blood pump (6) configured to be coupled to a pump section of the blood withdrawal line (6); at least a post-infusion line (13, 13?) connected to the blood return line (7) upstream of the heating zone (14); an air trapping device (9) placed on the blood return line (7) upstream of the heating zone (14).
    Type: Grant
    Filed: July 4, 2018
    Date of Patent: November 29, 2022
    Assignee: Gambro Lundia AB
    Inventor: Dominique Pouchoulin
  • Patent number: 11486749
    Abstract: The application discloses a time-of-flight generating circuit, coupled to a first transducer and a second transducer, wherein there is a distance greater than zero between the first transducer and the second transducer, and a fluid having a flow speed flows sequentially through the first transducer and the second transducer, wherein the time-of-flight generating circuit includes: a transmitter, coupled to the first transducer; a receiver, coupled to the second transducer; a signal processing circuit, coupled to the transmitter and the receiver; and a correlation circuit, a measuring circuit and a transformation circuit, coupled to the signal processing circuit. The application also discloses a chip, flow meter, and method of the same.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: November 1, 2022
    Assignee: SHENZHEN GOODIX TECHNOLOGY CO., LTD.
    Inventor: Yen-Yin Huang
  • Patent number: 11452543
    Abstract: Device and method for comminution or inactivation of circulating tumor cells (CTC) or tumor cell clusters (CTCC) from a tumor-affected organ or organ part, wherein it is proposed that in the venous drain of the tumor-affected organ or organ part a pump (2) with a pressure-increasing section and a pressure-reducing throttle (13) is arranged and is operated at the output side in its design point given by volumetric flow (Q) and pumping pressure (p) according to the volumetric flow and the blood pressure of the venous drain of the tumor-affected organ or organ part. Circulating tumor cells (CTC) and tumor cell clusters (CTCC) are thus comminuted and inactivated to thus reduce the risk of metastasis formation in cancerous diseases.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: September 27, 2022
    Assignees: Griesmühle Kleinkraftwerk GmbH, Universität Basel, Johannes Kepler Universität Linz
    Inventors: Nicola Aceto, Werner Baumgartner, Kurt Priesner
  • Patent number: 11419981
    Abstract: A priming system including a resilient chamber having flexible walls and a first check valve in a first fluid pathway between the resilient chamber and a fluid reservoir such that a fluid flows through the first check valve only in a direction from the fluid reservoir toward the resilient chamber and the fluid returns to the fluid reservoir through a second fluid pathway between the resilient chamber and the fluid reservoir upon compression of the walls of the resilient chamber.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: August 23, 2022
    Assignee: CAREFUSION 303, INC.
    Inventors: Jonathan Yeh, Jake R. Smith, Soon Y. Park, Tammy Nguyen
  • Patent number: 11324871
    Abstract: The present invention relates to a blood treatment machine having a control, having a pump actuator for pumping blood through an extracorporeal blood circuit which comprises an arterial line and a venous line, and having a pressure sensor for detecting the pressure in the venous line, wherein the control has a detection function for detecting a venous needle disconnect which compares a value determined on the basis of the pressure in the venous line with a limit value to recognize a venous needle disconnect, wherein the limit value with which the detection function compares the value determined on the basis of the pressure in the venous line can be set variably and/or is set variably by the control.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 10, 2022
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Reiner Spickermann, Pascal Kopperschmidt
  • Patent number: 11300474
    Abstract: A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: April 12, 2022
    Assignee: Gambro Lundia AB
    Inventors: Martin Furmanski, Anders Roslund, Bo Olde, Kristian Solem, Thomas Hertz, Jan Sternby
  • Patent number: 11298519
    Abstract: Systems and methods for improving kidney function. A first mechanical circulatory support system (MCS) is introduced in a patient's heart, and a second mechanical circulatory support system is introduced in a patient's inferior vena cava or renal vein. The second mechanical circulatory support system is operated while the first mechanical circulatory support system is operating. A renal parameter is monitored during. Combined operation of the two mechanical circulatory support systems results in a change in renal parameter, e.g. pressure drop in the renal vein, indicating an improvement in kidney function. Once the renal parameter is determined to be below a target threshold, operation of the second mechanical circulatory support device is stopped.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: April 12, 2022
    Assignee: Abiomed, Inc.
    Inventors: Noam Josephy, Jerald Wayne Curran, Randi Parks
  • Patent number: 11237033
    Abstract: An apparatus for measuring air flow in a duct includes a sensor fittable into connection with the duct. The sensor includes an ultrasound transmitter, at least two ultrasound receivers, and a control unit to which the ultrasound transmitter and ultrasound receivers are connectable. The apparatus further includes means for measuring temperature. In a method, with the apparatus, the temperature of the air and/or of a sensor in a duct is measured with means for measuring temperature. A sensor calibration measurement at the temperature in question is performed with the apparatus if a calibration of the sensor at the measured temperature and/or within a certain predefined temperature range has not been performed earlier from the environs of the measured temperature, and temperature compensation data for the measurement result of air flow, the data being formed on the basis of calibration measurement, is determined and/or recorded in memory with the apparatus.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: February 1, 2022
    Assignee: FläktGroup Sweden AB
    Inventors: Jari Mikkonen, Teuvo Sillanpää, Timo Lagerstam, Erkki Seppäläinen
  • Patent number: 11219709
    Abstract: According to some embodiments, a system may treat blood containing metformin outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 4 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: January 11, 2022
    Assignee: HUMANITY LIFE EXTENSION LLC
    Inventors: Patrick Richard Spearman, Shelly Amann
  • Patent number: 11207451
    Abstract: An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid (16, 20, 21, 26) and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: December 28, 2021
    Assignee: Gambro Lundia AB
    Inventors: Hiram Rada, Dominique Pouchoulin, Georges Vantard, Alain Frugier
  • Patent number: 11181132
    Abstract: Apparatuses for flowing multiple fluids in a single channel while substantially maintaining fluid separation are disclosed. In one configuration, the apparatus includes a first internal surface portion with an affinity to a first fluid and a second internal surface portion with an affinity to a second fluid. In another configuration, the apparatus includes a first fluid channel portion, a second fluid channel portion wrapped helically around the first fluid channel portion, and an opening therebetween. Also disclosed is an apparatus for maintaining substantially even fluid flow in fluid pathways having a first flow resistor portion, a second flow resistor portion, and a fluid channel therebetween.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 23, 2021
    Assignee: Vivonics, Inc.
    Inventors: Anna Galea, Joseph Beuford Parse, Kylie Stengel, Kristen LeRoy, Minh Duong, Samuel Harrington Warner, Andrew Evan Kamholz, Brandon Johnson
  • Patent number: 11160908
    Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 2, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Jeffrey Olson
  • Patent number: 11123468
    Abstract: A filtering device receives a pressure signal (P) from a pressure sensor in a fluid containing system, the pressure signal (P) comprising first pulses originating from a first periodic pulse generator and second pulses. The device acquires a reference signal which is indicative of a current operating frequency of the first periodic pulse generator. The device identifies, based on the reference signal, a plurality of harmonics (v1-v8) associated with the current operating frequency, computes correlation values (?1-?8) between the harmonics and the pressure signal (P) within a time window in the pressure signal (P), and generates a filtered signal by subtracting, as a function of the correlation values (?1-?8), the harmonics from the pressure signal (P). The use of correlation values is a direct, fast, robust and computation-efficient approach for estimating the signal contribution (d) from first pulses in the pressure signal (P).
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: September 21, 2021
    Assignee: Gambro Lundia AB
    Inventors: Kristian Solem, Bo Olde, Jan Sternby
  • Patent number: 11083828
    Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysis fluid circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for determining or receiving a proposed value (Condprop) of a conductivity for the dialysis fluid in the dialysis supply line (8) and to determine a set value (Condset) for the conductivity in the dialysis fluid as a function of the proposed value (Condprop) and as a function of at least one of a second parameter (UF volume/W; WL/W) indicative of a patient fluid overload and a third parameter (gconc) chosen in the group including: a glucose concentration in the patient and a concentration-related parameter of at least glucose in the patient.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: August 10, 2021
    Assignee: GAMBRO LUNDIA AB
    Inventor: Jan Sternby
  • Patent number: 11045300
    Abstract: Systems, devices, and methods for organ Retroperfusion along with regional mild hypothermia. One such system includes a hypothermia system including a hypothermia system outlet and a hypothermia system inlet; and a connector comprising a coolant inlet, a coolant outlet, a coolant reservoir, and a blood lumen, whereby the coolant inlet is configured to couple to the hypothermia system outlet and whereby the coolant outlet is configured to couple to the hypothermia system inlet; whereby a cooling product, when the hypothermia system is connected to the connector, can flow from the hypothermia system, through the hypothermia system outlet, into the coolant inlet, through the coolant reservoir, into the coolant outlet, and into the hypothermia system inlet, so that the cooling product can cool blood flowing through the blood lumen.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: June 29, 2021
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr., Zachary Berwick
  • Patent number: 11045595
    Abstract: A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: June 29, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
  • Patent number: 10994074
    Abstract: A pump for infusing fluid, the pump including a pumping mechanism, a fluid delivery device, a plurality of electric field sensors, and a measurement component. The plurality of electric field sensors is configured to estimate either an electric field that is associated with a patient, or an electric field that is associated with a fluid path of the pump, or both. The measurement component is configured to receive the electric field estimates from each of the electric field sensors and further configured to measure the difference between the electric field estimates.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 4, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: David Blumberg, Jr., Michael F. Bellino
  • Patent number: 10993808
    Abstract: Delivery devices and device elements that provide steering capabilities and methods of steering such delivery devices during the delivery of a stented prosthesis to a target site. Various delivery devices include a shaft assembly having a plurality of lumens through which tension members that compressively retain the stented prosthesis to the shaft assembly are routed. By selectively tensioning one or more tension members, the shaft assembly can be pulled or steered in a desired direction. Various embodiments include one or more steering or stiffening rods that can reinforce the device or counteract any unintended bending or steering of the delivery device.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: May 4, 2021
    Assignee: Medtronic, Inc.
    Inventors: Michael Gloss, James R. Keogh, Timothy Ryan, Declan P. Costello, Wayne M. Falk
  • Patent number: 10864311
    Abstract: A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UFD) as a volume withdrawal on the basis of a pressure difference (?P) and a temperature difference (?T) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UDF) is calculated using the pressure difference (?P) established on the basis of fluid pressure values determined by the pressure sensors, and the temperature difference (?T) established on the basis of temperature values determined by the temperature sensors.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: December 15, 2020
    Assignee: B. BRAUN AVITUM AG
    Inventor: André Wagner
  • Patent number: 10835868
    Abstract: A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36).
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 17, 2020
    Assignee: GAMBRO LUNDIA AB
    Inventors: Olof Jansson, Björn Ericson
  • Patent number: 10828413
    Abstract: A system and method for the practice of apheresis employs modules in the system which can be selected for a particular patient to treat particular situations or combinations of difficulties. In one example, Gal-3 mediates a large number of body reactions, and is an effective protector of tumor microenvironments and the like, as well inflammation driver. Removal of Gal-3 may make antic-cancer treatments, like photopheresis and TNF administration more effective. Separate modules, such as one for photopheresis and one for TNF receptor removal, may be combined with a module for the reduction of Gal-3, to render the combination of treatments each more effective than if administered alone.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: November 10, 2020
    Assignee: ELIAZ THERAPEUTICS, INC.
    Inventor: Isaac Eliaz
  • Patent number: 10792415
    Abstract: A failsafe system for a medical fluid procedure, comprising a medical fluid processing apparatus comprising a sealer and a programmable controller driven by software, wherein the programmable controller is programmed to recognize a failure event from input from hardware components of the medical fluid processing apparatus. The system also comprises a disposable fluid circuit configured to associate with the medical fluid processing apparatus and comprising a tubing segment configured to fit within the sealer. The programmable controller is configured to seal the tubing segment by activating the sealer surrounding the tubing segment in response to an occurrence of the failure event.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: October 6, 2020
    Assignee: Fenwal, Inc.
    Inventor: James Darren Roxas
  • Patent number: 10722636
    Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: July 28, 2020
    Assignee: MEDTRONIC, INC.
    Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
  • Patent number: 10702643
    Abstract: For regulating and presetting the pump rate of a blood pump, a device and a method are configured for monitoring blood pressure values upstream and/or downstream from the blood pump. The monitored values, or another value formed from the monitored values, are compared with a limit value, which depends on an operating parameter or a pump parameter of the blood pump. In violation of the limit value, the pump rate of the blood pump is modified to such an extent, or a new pump rate is determined, such that the limit value is no longer violated or the degree of violation is reduced.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: July 7, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christoph Wiktor, Arne Peters, Alexander Heide, Manfred Weis
  • Patent number: 10625013
    Abstract: A monitoring device is operated to detect a disruption of a fluid connection between two fluid containing systems. A disruption detector in the monitoring device operates on a measurement signal (Pi) to detect an apparent disruption of the fluid connection and generate a corresponding alarm indication. The monitoring device is configured to optimize the configuration of the disruption detector to limit the number of false alarms, by operating a false alarm analyzer to produce a count (FA #) of false alarm indications generated per unit time by the disruption detector for one or more configurations (?L) of the disruption detector, and by operating an updater to update the configuration (?L) of the disruption detector based on the count (FA #). The monitoring device may be connected to or part of an apparatus for blood treatment and operable to detect a disconnection of an extracorporeal blood circuit from a vascular system of a patient, e.g. a venous-side disconnection.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: April 21, 2020
    Assignee: GAMBRO LUNDIA AB
    Inventor: Jan Sternby
  • Patent number: 10596315
    Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: March 24, 2020
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Richard G. Patton, Shan E. Gaw
  • Patent number: 10551803
    Abstract: The present invention relates to a method of adapting of a second threshold window of at least a second measured variable depending on the change of a first threshold window of a first measured variable, wherein the adaptation is performed by the use of a control unit having been provided and/or configured therefor. The present invention further relates to a control device, a medical treatment apparatus, a medical monitoring apparatus, a digital storage means, a computer program product and a computer program.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 4, 2020
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Martin Gruendken, Uwe Herrmann, Sabine Kipp, Christine Nachbaur-Sturm, Thomas Pusinelli
  • Patent number: 10463778
    Abstract: A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: November 5, 2019
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Rodolfo Roger, Robert Childers, Thomas D. Kelly
  • Patent number: 10441703
    Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 15, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
  • Patent number: 10385312
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: August 20, 2019
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Patent number: 10350344
    Abstract: The invention relates to a method of monitoring an extracorporeal blood treatment apparatus having an extracorporeal blood circuit and in particular a venous needle disconnection by means of pressure pulse measurement at the extracorporeal blood circuit. The invention further relates to an apparatus for carrying out a monitoring method and to a blood treatment apparatus which includes a corresponding monitoring apparatus.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: July 16, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christoph Wiktor, Alexander Heide, Arne Peters
  • Patent number: 10322219
    Abstract: The present invention relates to a method of determining the pressure or of a parameter correlated with the pressure in an extracorporeal circuit of a blood treatment apparatus, in particular of a dialyzer, wherein at least one blood pump which is driven by at least one motor is located in the blood circuit, wherein the motor current of the named motor and the blood flow or a parameter correlated therewith is measured for determining the pressure or the parameter correlated therewith and wherein the pressure p or the parameter correlated therewith is calculated from the measured values.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: June 18, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Alfred Gagel, Benedict Glaser, Haitham Ibrahim, Pascal Kopperschmidt
  • Patent number: 10273456
    Abstract: Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 30, 2019
    Assignee: FENWAL, INC.
    Inventors: Katherine Radwanski, Kyungyoon Min
  • Patent number: 10213462
    Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis, comprising at least in part donor apheresis, using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: February 26, 2019
    Assignee: ELIAZ THERAPEUTICS, INC.
    Inventor: Isaac Eliaz