Oxygenating Means Patents (Class 604/6.14)
  • Patent number: 11918719
    Abstract: Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such “counter” or “countercurrent” flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: March 5, 2024
    Assignee: Sorin Group Italia S.r.l.
    Inventor: Gabriele Tommasi
  • Patent number: 11904129
    Abstract: The present invention relates to a connector system for use in connecting conduits together, such as those used with an extracorporeal blood circulation system. The system has a male and female connector and a seal. The seal is operatively associated with the male and female connectors and forms a fluid tight connection between the male and female connectors. An inner surface of the seal and the inner surfaces of the first and second coupling ends form a continuous and smooth transitional surface.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: February 20, 2024
    Assignee: MAQUET CARDIOPULMONARY GMBH
    Inventors: Ulrich Haag, Ralf Engelhardt
  • Patent number: 11844939
    Abstract: The invention relates to a blood pump for the invasive application within a body of a patient comprising a rotor which is drivable about an axis of rotation and is radially compressible or expandable and which has a hub and at least one impeller blade fastened thereto, as well as comprising a housing which is compressible or expandable in the radial direction by an axial stretching or axial compression. The object of making both the rotor and the housing expandable and compressible in as simple a manner as possible is achieved in accordance with the invention in that a control body is provided which passes through the hub in the longitudinal direction, which is freely axially displaceable relative to the hub and which is coupled to the housing on the distal side of the rotor such that it exerts pulling and/or compression forces on the housing by a movement in the longitudinal direction with respect to the housing.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: December 19, 2023
    Assignee: ECP ENTWICKLUNGSGESELLSCHAFT MBH
    Inventors: Thomas Toellner, Mario Scheckel
  • Patent number: 11738127
    Abstract: An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: August 29, 2023
    Assignee: SPECTRUM MEDICAL GROUP LIMITED
    Inventors: Stephen Turner, Daniele Galavotti
  • Patent number: 11696980
    Abstract: A device for perfusing a coronary sinus of a subject's heart which may include: a double-lumen catheter including: a first lumen having: a proximal opening, and a distal opening configured to be positioned in a coronary sinus of a subject's heart; and a second lumen parallel to the first lumen, the second lumen having: a proximal opening, and a distal opening being offset from the distal opening of the first lumen towards the proximal opening of the second lumen in a longitudinal direction, the distal opening of the second lumen being configured to be positioned in a right atrium of the subject's heart; and an oxygenator connected to the proximal openings of the first lumen and the second lumen, the oxygenator is configured to oxygenate deoxygenated blood.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: July 11, 2023
    Assignee: SHAARE ZEDEK SCIENTIFIC LTD.
    Inventors: Ehud Jacobzon, Yaniv Ben-Haim
  • Patent number: 11666349
    Abstract: An endovascular apparatus includes a first cannula, a second cannula, and an operator handle. The first cannula has a proximal end, a distal end, and a first lumen. The second cannula is slidably coupled to the first cannula. The second cannula has a proximal end portion, a distal end portion, and a second lumen. The distal end portion is extendable in a distal direction beyond the distal end of the first cannula. The operator handle is operably coupled to the second cannula. The operator handle may be configured to articulate the distal end portion of the second cannula relative to the first cannula. The second cannula may include an articulation joint. Optionally, the operator handle may be configured to extend, retract, and rotate the second cannula relative to the first cannula. Also, optionally, the endovascular apparatus may include a magnetic coupler.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: June 6, 2023
    Assignee: C.R. Bard, Inc.
    Inventors: Nir Herlinger, Jessica Lynn Roll Hoye, Kevin Hugh Vincent Boyle
  • Patent number: 11541158
    Abstract: An exhaust gas flow control system for an oxygenator of an extracorporeal ventilation system connected to an oxygenation gas supply line and to an exhaust line for removal of exhaust gas comprises a flow control path, a pressure control path, an exhaust flow regulator responsive to the controller, and an exhaust gas pressure regulator responsive to a controller configured to maintain a pre-determined pressure level in the exhaust line. This provides a better degree of control over the pressure across the oxygenator from oxygenation gas inlet to exhaust.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: January 3, 2023
    Assignee: Spectrum Medical Ltd.
    Inventors: Stephen Turner, Benjamin David Garbutt
  • Patent number: 11406300
    Abstract: Images of an individual can be obtained and analyzed to determine an amount of facial paralysis of the individual. The images can also be analyzed to determine an amount of gaze deviation of the individual. The amount of facial paralysis of the individual and/or the amount of gaze deviation of the individual can be used to determine a probability that the individual experienced a biological condition.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: August 9, 2022
    Assignee: iSchemaView, Inc.
    Inventor: Roland Bammer
  • Patent number: 11400197
    Abstract: A pulmonary artery (PA) via trans-septal to left atrial (LA) percutaneous dual lumen cannulation system which reduce the pressure of the right ventricle provides drainage of pulmonary artery blood with bypassing the lung while return the blood to the Left Atrium (LA) without the need for thoracotomy for a wearable pump less extra corporeal lung assist (pECLA) to remove CO2, pump less extra corporeal membrane oxygenation (ECMO), para-corporeal pump driven CO2 removal, extra corporeal CO2 removal (ECCO2R) pump driven, para-corporeal pump driven membrane oxygenation, or extra corporeal membrane oxygenation (ECMO) with extra-corporeal pump. By establishing percutaneously a shunt with a dual lumen cannula between PA and LA using the PA-LA pressure gradient as the driving force for the blood flow through the drainage lumen, CO2 removal device, or oxygenator and return cannula lumen in the vascular system.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: August 2, 2022
    Inventors: Torsten Heilmann, Sabine Post
  • Patent number: 11351345
    Abstract: Systems and methods for selective auto-retroperfusion along with regional mild hypothermia.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: June 7, 2022
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 11298452
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: September 22, 2018
    Date of Patent: April 12, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Patent number: 11155710
    Abstract: The present invention relates to a composition comprising at least one aromatic polymer and at least one fluorinated polymer, articles made from such compositions and uses thereof.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 26, 2021
    Assignee: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.
    Inventors: Emanuele Di Nicolo', Patrizia Maccone, Silvia Rita Petricci, Pasquale Campanelli
  • Patent number: 11040128
    Abstract: To enhance diffusive mass transfer of small molecules and convective clearance of middle molecules, the present invention provides a cylindrical hemodialyzer which comprises a blood compartment having a packed bundle of hollow fibers in a doughnut configuration on a radial cross-section, and a motorized dialysate compartment comprising a dialysate inlet motor having an external stator and an internal rotor connected to an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers. The cylindrical hemodialyzer is configured to recirculate dialysate across the packed bundle of the hollow fibers propelled by the dialysate inlet motor. A dialysate outlet motor of the motorized dialysate compartment having an external stator and an internal rotor is configured to drain the dialysate and to control ultrafiltration by said cylindrical hemodialyzer.
    Type: Grant
    Filed: January 25, 2020
    Date of Patent: June 22, 2021
    Inventor: Choon Kee Lee
  • Patent number: 11013841
    Abstract: To enhance diffusive mass transfer of solutes, the present hemodialyzer in a cylindrical configuration for hemodialysis comprises a blood compartment having a packed bundle of hollow fibers in a reversibly distensible doughnut configuration on a radial cross-section, and a dialysate compartment having an axial spiral flow converter slidably inserted in a center of the packed bundle of the hollow fibers and an outer circumferential space encircling an outer circumferential layer of the packed bundle of the hollow fibers. The axial spiral flow converter is configured to convert an axial dialysate flow to a centrifugal dialysate flow radially spreading from the center of the packed bundle of the hollow fibers to the outer circumferential space of the hemodialyzer.
    Type: Grant
    Filed: September 28, 2019
    Date of Patent: May 25, 2021
    Inventor: Choon Kee Lee
  • Patent number: 10842925
    Abstract: The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: November 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Rishi Kant, Shuvo Roy, Benjamin Chui, Kenneth G. Goldman
  • Patent number: 10449337
    Abstract: Systems and methods for selective auto-retroperfusion along with regional mild hypothermia.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: October 22, 2019
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10350384
    Abstract: A cannula assembly for directing blood from the heart of a patient and a minimally invasive method of implanting the same. The cannula assembly includes a flexible cannula body having a proximal end and a distal end with a receiving portion, and a transseptal tip having a distal end and a proximal end with an engaging portion. First and second anchors are coupled to the transseptal tip and configured to be deployed from a contracted state to an expanded state. The engaging portion of the transseptal tip is operable to removably engage the receiving portion of the flexible cannula body in vivo.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: July 16, 2019
    Assignee: CircuLite, Inc.
    Inventors: Robert C. Farnan, Scott A. Olson, Elizabeth Jung, Andrew J. Dusbabek, Robert G. Hudgins
  • Patent number: 10245367
    Abstract: The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: April 2, 2019
    Assignee: HeartWare, Inc.
    Inventor: Martin Strueber
  • Patent number: 9757545
    Abstract: Devices, systems, and methods for auto-retroperfusion of the cerebral venous system. In an exemplary embodiment of a catheter for controlling blood perfusion pressure of the present disclosure, the catheter comprises a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen and adapted to move between an expanded configuration and a deflated configuration, and at least one sensor coupled with the distal end of the body, each of the at least one sensors adapted to gather data relating to a fluid flowing through the lumen, wherein the catheter is configured to be coupled to a flow unit for regulating the flow and pressure of a fluid.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: September 12, 2017
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9724232
    Abstract: Systems and methods for selective auto-retroperfusion along with regional mild hypothermia.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 8, 2017
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 9675357
    Abstract: A method for performing a coronary artery bypass graft procedure on a patient to connect a bypass vessel to a target vessel includes the steps of creating an opening in the patient that communicates with the thoracic cavity of the patient; providing a bypass vessel having a lumen and at least one free end; passing the free end of the bypass vessel from the thoracic cavity through the opening to a position outside the body of the patient; attaching a connector to the free end of bypass vessel while the free end of the bypass vessel is outside the body of the patient; passing the free end of the bypass vessel from the position outside the body of the patient through the opening and into the thoracic cavity; and connecting the free end of the bypass vessel to a target vessel with the connector.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: June 13, 2017
    Assignee: Innovative Interventional Technologies, B.V.
    Inventors: Wilhelmus Joseph Leonardus Suyker, Paulus Thomas Wilhelmus Suyker
  • Patent number: 9463083
    Abstract: Apparatus is provided, including a housing configured for insertion into a body of a subject; at least one oxygen reservoir disposed within the housing; and at least one layer of transplanted cells, disposed within the housing; and gaseous oxygen disposed within the at least one oxygen reservoir. Other embodiments are also described.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 11, 2016
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Yaki Stern, Yoram Rozy
  • Patent number: 9439804
    Abstract: Method for treatment of a body of a mammal in cardiac arrest, comprising the step of performing a therapeutic hypothermia of the body after the cardiac arrest has occurred, said therapeutic hypothermia comprising: cooling the body to a target temperature during a cooling time period, said cooling being performed by total liquid ventilation which comprises alternately filling lungs of the body with a cooling liquid and removing from the lungs said cooling liquid, maintaining the body at the target temperature for a hypothermia duration.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: September 13, 2016
    Inventors: Renaud Tissier, Alain Berdeaux
  • Patent number: 9108000
    Abstract: Devices, systems, and methods for auto-retroperfusion of the cerebral venous system. In an exemplary embodiment of a catheter for controlling blood perfusion pressure of the present disclosure, the catheter comprises a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen and adapted to move between an expanded configuration and a deflated configuration, and at least one sensor coupled with the distal end of the body, each of the at least one sensors adapted to gather data relating to a fluid flowing through the lumen, wherein the catheter is configured to be coupled to a flow unit for regulating the flow and pressure of a fluid.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: August 18, 2015
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9024746
    Abstract: An automatic locking system for a medical treatment device helps to ensure that an assistant is present during treatment of a patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Nxstage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, James M. Brugger
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 9005187
    Abstract: An implantable oxygen generator system is disclosed. The implantable oxygen generator system includes a receiver configured to generate an electrical current, and an electrode set configured to deliver the electrical current to water molecules of an interstitial fluid within a tissue, wherein the electrical current electrolyzes the water molecules into oxygen molecules.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: April 14, 2015
    Assignee: Purdue Research Foundation
    Inventors: Babak Ziaie, Teimour Maleki
  • Patent number: 8974405
    Abstract: A dialysis fluid cassette that includes a rigid body and a flexible backing covering a recessed portion of the rigid body to at least partially form a gas release chamber.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: March 10, 2015
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Thomas Irvin Folden, Martin Joseph Crnkovich, Christian Schlaeper, Lynn Jensen, Mohsen Reihanifam
  • Patent number: 8968652
    Abstract: An oxygenator that inhibits or prevents bubbles in blood from exiting through a blood outlet includes an oxygenator part which performs gas exchange on blood and a heat exchanging part which performs heat exchange on the blood. The oxygenators part has a housing that is generally in a rectangular parallelepiped form, with a hollow fiber membrane bundle positioned in the housing. The hollow fiber membrane bundle is formed by a multiplicity of hollow fiber membranes adapted to perform gas exchange. Blood flows along a blood passage comprised of gaps between the hollow fiber membranes and contacts the surface of the hollow fiber membranes where gas exchange occurs with gas flowing through the lumens of the hollow fiber membranes. In addition, a filter member is arranged on a downstream side of the hollow fiber membrane bundle so that bubbles present in the blood are caught by the filter member.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: March 3, 2015
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Mitsuaki Ogihara
  • Patent number: 8951220
    Abstract: The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: February 10, 2015
    Assignee: ZOLL LifeBridge GmbH
    Inventors: Gerhard Brieske, Michael Brieske
  • Patent number: 8939926
    Abstract: A system and method for removing gas bubbles from blood during circulatory assist procedures. An active filter apparatus forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: January 27, 2015
    Assignee: Indian Wells Medical, Inc.
    Inventors: David W. Wieting, Jay A. Lenker
  • Patent number: 8936563
    Abstract: A method for connecting medical tubing or any other type of fluidic circuit conduits (e.g., cannulae) to a ventricular assist device (“VAD”) or any other pumping device used for blood pumping during cardiac circulatory support for vascular surgery. The method prevent air bubbles from entering a cardiac circulatory support system when connecting cannulae to a VAD that may later enter the blood stream of a patient during cardiac surgery, and also provide for purging any air bubbles that may have entered the cardiac circulatory support system during a cannulae-VAD connection.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: January 20, 2015
    Assignee: Vitalmex International S.A. de C.V.
    Inventor: Benjamin Duenas
  • Patent number: 8911666
    Abstract: A filter member used in an oxygenator is constructed to provide improved contact with a hollow fiber membrane bundle and to capture bubbles contained in blood. The filter member possesses elasticity at least in the circumferential direction to allow the inner circumference of the filter member to be increased from a natural non-expanded state prior to placement on the hollow fiber membrane bundle to an expanded state in which the inner circumference of the filter member is increased when placed on the hollow fiber membrane bundle. The filter member is constructed to satisfy the condition 0.5?L2/L1<1, wherein L1 represents the outer circumference of the hollow fiber membrane bundle and L2 represents the inner circumference of the filter member in the natural non-expanded state.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 16, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Kazuhiro Mizoguchi, Eiji Kato
  • Patent number: 8911391
    Abstract: A system for connecting medical tubing or any other type of fluidic circuit conduits (e.g., cannulae) to a ventricular assist device (“VAD”) or any other pumping device used for blood pumping during cardiac circulatory support for vascular surgery. The system prevents air bubbles from entering a cardiac circulatory support system when connecting cannulae to a VAD that may later enter the blood stream of a patient during cardiac surgery, and also provide for purging any air bubbles that may have entered the cardiac circulatory support system during a cannulae-VAD connection.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: December 16, 2014
    Assignee: Vitalmex Internacional S.A. de C.V.
    Inventor: Benjamin Duenas
  • Patent number: 8906300
    Abstract: A blood oxygenator includes an integral pneumatic pump disposed substantially within a housing thereof, an inlet blood flow redirector, and an outflow blood collector. An atrium provided at an inlet of the oxygenator promotes even delivery of blood to the oxygenator. In use, the oxygenator provides an even dispersion of blood therethrough, establishing even perfusion and reducing areas of stagnant blood flow.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 9, 2014
    Assignee: The University of Kentucky Research Foundation
    Inventors: Dongfang Wang, Joseph B. Zwischenberger
  • Patent number: 8888730
    Abstract: The disclosure pertains to a perfusion system that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system in which at least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system in order to unlock further functionality within the perfusion system.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: November 18, 2014
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Ivan Rossi, Raffaella Bombarda
  • Patent number: 8888737
    Abstract: A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes or other ischemic conditions. A method and apparatus is described that allows mitigation of oxygen-related injury by precisely modulating the level of oxygen re-exposure during reoxygenation by a controlled feedback loop based on parameters of the tissue measured by a real-time tissue sensor or probe.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: November 18, 2014
    Assignee: Rheoxtech, LLC
    Inventors: Gintaras A. Vaisnys, Neil J. Thomas, James G. Moore
  • Patent number: 8882693
    Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: November 11, 2014
    Assignee: ZOLL LifeBridge GmbH
    Inventors: Gerhard Müller-Spanka, Hans-Reinhard Zerkowski
  • Patent number: 8882695
    Abstract: The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: November 11, 2014
    Assignee: Mecora Medizintechnik GmbH
    Inventor: Oliver Marseille
  • Patent number: 8834399
    Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage de-airing of blood to provide automated cardiopulmonary replacement to preserve the viability or one or more organs in a clinically dead organ donor or harvested donor organ for subsequent transplantation to an organ receiver patient.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: September 16, 2014
    Assignee: ZOLL LifeBridge GmbH
    Inventors: Gerhard Muller-Spanka, Hans-Reinhard Zerkowski
  • Patent number: 8795220
    Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to provide a circumferential blood flow through the heat exchanger and/or gas exchanger.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: August 5, 2014
    Assignees: Politecnico di Milano, Sorin Group Italia S.r.l.
    Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Giri, Alberto Redaelli, Claudio Silvestri, Gabriele Tommasi
  • Patent number: 8795591
    Abstract: An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: August 5, 2014
    Assignee: Medtronic, Inc.
    Inventors: Stephen Roller, Christopher Plott, Alford McLevish, Gregory Hake, Brian Steffens
  • Patent number: 8747742
    Abstract: A heat exchanger includes a case, a bottom member and a plurality of heat transfer pipes (a pipe group) loaded in the heat exchanger case, in which blood flows from one end through the bottom member. The bottom member has an annular wall, a bottom surface, and a blood inlet port. The bottom surface is opposed to one end of the heat transfer pipe. The bottom surface includes a groove portion and a raised bottom portion provided on each of opposing end sides of the groove portion. The raised bottom portion is inclined such that a distance between the raised bottom portion on a side where the blood inlet port is provided and one end of the heat transfer pipe is smaller than a distance between the raised bottom portion opposite to the side where the blood inlet port is provided and one end of the heat transfer pipe.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: June 10, 2014
    Assignee: Nipro Corporation
    Inventors: Shin-ichi Kawamura, Kazuhisa Ishihara, Naoaki Yasumura
  • Patent number: 8734376
    Abstract: A perfusion system is easy to set-up, use and monitor during a bypass procedure. At least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system. A blood level sensor can be used to monitor a blood level or volume within a blood reservoir.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: May 27, 2014
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Dennis Simpson, Derek E. Dahlinger, Ivan Rossi
  • Patent number: 8734375
    Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: May 27, 2014
    Assignee: Universitá degli Studi di Milano-Bicocca
    Inventors: Antonio Maria Pesenti, Nicolò Antonino Patroniti
  • Patent number: 8721579
    Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure such as cardiopulonary bypass graft surgery, keyhole cardiopulonary bypass graft surgery, percutaneous angioplasty, percutaneous stent placement, and percutaneous etherectomy.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: May 13, 2014
    Assignee: ZOLL LifeBridge GmbH
    Inventors: Gerhard Müller-Spanka, Hans-Reinhard Zerkowski
  • Patent number: 8685320
    Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 1, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiro Mizoguchi
  • Patent number: 8685319
    Abstract: A combination oxygenator and arterial filter device for treating blood in an extracorporeal blood circuit. The device includes a housing maintaining a core and a fiber bundle. The fiber bundle is formed by a plurality of hollow fibers continuously helically wound about the core to form layers of level wound fibers. The layers combine to define an oxygenator region and a radially outward depth filter region. A minimum gap spacing between fibers of the oxygenator region layers is greater than a minimum gap spacing of the depth filter region layers. The fiber bundle can function as a blood oxygenator and exhibits a filtration efficiency of not less than 92% in filtering particles having a particle size of about 45 microns. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: April 1, 2014
    Assignee: Medtronic, Inc.
    Inventors: Robert Olson, John L. Knoll
  • Patent number: 8672867
    Abstract: A cardiopulmonary bypass device may include a first tube configured for connection to a vein and a second tube configured for connection to an artery. The device may further include a pump connected between the first and second tubes. In a first mode, the pump may pump fluid in one direction and in a second mode, the pump may pump fluid in the opposite direction. A control unit may be coupled to the pump to control its operation. Lungs may functions as the oxygenator of the cardiopulmonary bypass device.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: March 18, 2014
    Assignee: Laerdal Medical AS
    Inventor: Helge Myklebust
  • Patent number: 8647410
    Abstract: The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: February 11, 2014
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, James Ching-Ming Hsiao, Tatiana Kniazeva