Blood Collection Container Patents (Class 604/6.15)
  • Patent number: 9498616
    Abstract: A flow control clamp having a first member and a second member movable from a first open position to a second irreversibly closed position wherein flow through a tube associated with the clamp is irreversibly prevented and cannot be restored. Systems and methods using such clamps are also disclosed.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: November 22, 2016
    Assignee: Fenwal, Inc.
    Inventors: Jean-Marie Mathias, Gianni DiStefani
  • Patent number: 9173987
    Abstract: A degassing module for removal of air and other gases during operation of a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The degassing module has a flow-through first chamber that has a hydrophobic vent membrane that has an exterior and interior side forming a portion of the flow-through chamber. The hydrophobic vent membrane is positioned at a higher elevation on the flow-through chamber than a fluid outlet. Fluid flows through the flow-through chamber in a downward direction relative to the hydrophobic vent membrane. A flow-through chamber has a cross sectional area configured to provide for a downward flow velocity of the fluid to be less than the upward rise velocity of a smallest bubble to be removed from the fluid.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: November 3, 2015
    Assignee: Medtronic, Inc.
    Inventors: Thomas E. Meyer, David B. Lura, Bryant J. Pudil, Martin T. Gerber
  • Patent number: 9028457
    Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: May 12, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Barry F. Hecker
  • Patent number: 9023292
    Abstract: Disclosed herein is a device for sampling blood by capillarity for separating a plasma phase of the blood from the cell phase. The device is a strip and includes a filter having a membrane with no clumping agents, a prefilter for spreading blood over the surface of the membrane; and an absorbent paper downstream from the filter. The membrane is dimensioned to cover only a part of the surface of the prefilter and the migration of blood by capillarity within the prefilter takes place essentially lengthwise relative to the strip before blood comes into contact with the membrane.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 5, 2015
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Hervé Rostaing, Christine Peponnet, Patrick Pouteau, Elodie Sollier
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 9005343
    Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 14, 2015
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Paul J. Vernucci
  • Publication number: 20150100009
    Abstract: Methods, devices and systems provide information regarding fluid capacity of a patient before, during or after surgeries in which hemodilution may be a concern, such as CPB, rather than providing only information regarding hematocrit levels. The fluid capacity of the patient may be displayed to allow a health care provider to make decisions regarding effects of addition of fluid to the blood compartment of the patient.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 9, 2015
    Applicant: Medtronic, Inc.
    Inventor: Mark Bearss
  • Patent number: 8986239
    Abstract: A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 24, 2015
    Assignee: Haemonetics Corporation
    Inventor: Alec D. Bobroff
  • Patent number: 8979788
    Abstract: A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: March 17, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Jason A. Demers, Larry B. Gray, James D. Dale, N. Christopher Perry, David E. Altobelli
  • Publication number: 20150057589
    Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.
    Type: Application
    Filed: April 29, 2014
    Publication date: February 26, 2015
    Inventor: Neil J. Thomas
  • Patent number: 8939926
    Abstract: A system and method for removing gas bubbles from blood during circulatory assist procedures. An active filter apparatus forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: January 27, 2015
    Assignee: Indian Wells Medical, Inc.
    Inventors: David W. Wieting, Jay A. Lenker
  • Patent number: 8905960
    Abstract: A device for the filtration of a complex fluid composition such as blood, includes a base (12) with a bottom (18), a top (14) with a bottom (30), and a membrane (16) that is arranged between the base and the top so as to define a low chamber C1 and a high chamber C2, with an input tap (26) of the complex composition that is to be filtered emptying into the low chamber C1, an output tap (28) of the retentate with elements for adjusting the flow rate emptying into this same low chamber C1, and an output tap (36, 36-1) of the high chamber C2, whereby this output tap (36, 36-1) of the permeate is subjected to negative pressure.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: December 9, 2014
    Assignee: Direction et Priorites
    Inventors: Francis Gadrat, Bertrand Chastenet
  • Patent number: 8900175
    Abstract: A collecting device for fluids for medical use may include a rigid container internally defining a first chamber having a fixed volume, an auxiliary container having a deformable portion defining internally thereof a second chamber having a variable volume as a function of a deformable portion thereof, a passage able to set the first and the second chamber in fluid communication, an inlet port connected to at least one of the containers, and an outlet port connected to at least one of the containers, as well as a bypass line for bypassing the device.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: December 2, 2014
    Inventor: Giovanni Pinto
  • Patent number: 8882696
    Abstract: The present invention consists of a venous blood reservoir that has a separate blood chamber to filter vent blood and a separate chamber to filter sucker blood. The two blood chambers are separated by a common wall and are in fluid communication along their top assuring that vacuum applied to the top of either is equally applied to the other. A mean to form communication across the wall allows the user to either accumulate sucker blood in its chamber while letting vent blood to flow freely to the venous blood chamber. Alternately, user can let the blood in the sucker chamber to combine with the venous blood freely too.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: November 11, 2014
    Inventor: Yehuda Tamari
  • Patent number: 8852433
    Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: October 7, 2014
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 8834402
    Abstract: A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: September 16, 2014
    Assignee: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8808551
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 19, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Patent number: 8747342
    Abstract: An air separator (1) comprises a first chamber (2) where blood or other fluid can be received, an inlet and an outlet port associated to the bottom wall (4) and in fluid communication with the first chamber. A first channel (14) extending along the lateral wall of the separator and has a first and a second portion (16 and 18). The channel second portion (18) terminally forms an orifice (15) facing the chamber and extending in an area closer to a top wall (5) of the chamber (2) than to the bottom wall of the same chamber. The orifice faces the top of the separator and has a flow passage cross section greater than that of a first portion (16) of the channel.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: June 10, 2014
    Assignee: Gambro Lundia AB
    Inventors: Luca Caleffi, Francesco Ribolzi, Ranko Sakota
  • Publication number: 20140142491
    Abstract: An apparatus for providing an extracorporeal blood circuit control includes a base module having a control device and a patient module releasably connected to the base module and having blood-conducting components of the extracorporeal blood circuit. A pivot system is also provided at the base module and at the patient module to pivot the patient module relative to the base module about a horizontal axis.
    Type: Application
    Filed: September 4, 2013
    Publication date: May 22, 2014
    Applicant: ZOLL LIFEBRIDGE GMBH
    Inventor: Gerhard Brieske
  • Patent number: 8685258
    Abstract: Systems and methods are provided for conveying an amount of red blood cells and an amount of plasma to a blood source. Blood is conveyed from a blood source into a separation device and the separation device is operated to separate the blood into a layer containing red blood cells and a layer containing plasma. Red blood cells and plasma are removed from the separation device and volumes of the red blood cells and plasma are conveyed to the blood source. The volumes of red blood cells and plasma are alternately conveyed to the blood source for said amounts of red blood cells and plasma.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: April 1, 2014
    Assignee: Fenwal, Inc.
    Inventors: Lan T. Nguyen, Kyungyoon Min, Tony Nguyen
  • Patent number: 8679601
    Abstract: A medical fluid container of a flexible plastic material is produced as follows: at first, a plastic compound is produced from a heterogeneous mixture of a first, lower-viscosity raw polymer component having a first melt viscosity and a second, higher-viscosity raw polymer component having a second melt viscosity which is greater than the first melt viscosity. Then the plastic compound is extruded. The extrudate is confectioned. Finally, the confectioned extrudate is sealed to form the finished fluid container. A film tubing may serve as intermediate product for the medical container. The medical container or the film tubing thus produced has surface structures with a typical average size of 15 to 200 ?m. The production method requires little effort while fulfilling demanding requirements with respect to the stability of the produced fluid container.
    Type: Grant
    Filed: December 8, 2007
    Date of Patent: March 25, 2014
    Assignee: Raumedic AG
    Inventors: Georg Kühlein, Martin Schenkel
  • Patent number: 8663146
    Abstract: Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: March 4, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Joel C. Higgins, Bruce Simon, Jennifer E. Woodell-May
  • Publication number: 20140050618
    Abstract: The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 20, 2014
    Inventors: Gerhard Breiske, Michael Brieske
  • Patent number: 8647291
    Abstract: An extracorporeal blood chamber (12) comprises an expansion reservoir (47) having a first access (48) arranged laterally and a second access (49) arranged on the bottom of the chamber (12). The chamber comprises, integrally with the reservoir, a first conduit terminating in the first access, a second conduit terminating in the first access, and a third conduit terminating in the second access. The extracorporeal blood enters the reservoir through the first conduit and there mixes with an infusion fluid which enters through the second conduit. The resulting mixture exits through the third conduit. The chamber is used in a hemo(dia)filtration apparatus to mix the blood optimally with the replacement fluid.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: February 11, 2014
    Assignee: Gambro Lundia AB
    Inventors: Francesco Ribolzi, Ranko Sakota, Luca Caleffi, Giuseppe Franzoni
  • Patent number: 8632487
    Abstract: The present invention relates to a device for controlling a system for transporting blood, and a method for transporting blood in a blood line of an extracorporeal blood circuit of an extracorporeal blood treatment system. The present invention also relates to an extracorporeal blood treatment device comprising such a system for transporting blood. The method and device according to the present invention are based on the fact that a defined threshold value for the pressure in the blood line should not be exceeded. The system for transporting blood is controlled in such a way the blood in the blood line is transported in a pre-determined volume flow as long as the pressure in the blood line is below the pre-determined threshold value. When the pressure in the blood line reaches the pre-defined threshold value, however, the system for transporting blood is controlled such that a pressure value corresponding to the threshold value is set when the blood is transported in the blood line.
    Type: Grant
    Filed: May 31, 2008
    Date of Patent: January 21, 2014
    Assignee: Fresenius Medical Care Deutchland GmbH
    Inventors: Götz Günther, Michael Herrenbauer, Martin Lauer, Ralf Müller
  • Patent number: 8617392
    Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: December 31, 2013
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 8603346
    Abstract: Disclosed is an apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 10, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins
  • Publication number: 20130303965
    Abstract: A perfusion system that is easy to set-up, use and monitor during a bypass procedure includes at least some disposable components configured to communicate parameters to the perfusion system. An ultrasonic blood level sensor can be used to monitor a blood level or volume within a blood reservoir. The blood level sensor may be utilized in an integrated perfusion system in which the disposable components are configured, as noted above, to communicate with the perfusion system.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 14, 2013
    Inventors: Ivan Rossi, Ivo Panzani
  • Patent number: 8545428
    Abstract: Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: October 1, 2013
    Assignee: Nxstage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Brian C. Green, Dennis M. Treu, Christopher S. McDowell, Goetz Friederichs
  • Patent number: 8535421
    Abstract: A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: September 17, 2013
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Paul J. Vernucci
  • Patent number: 8518258
    Abstract: A hemodialysis machine or hemodiafiltration machine is provided that may be used directly for sampling for the connection to a hemodialyzer or for providing replacement fluid, as is required for regular microbiological testing. The machine does not require any additional components or any complex hygiene measures to prevent secondary contamination. By connecting an inventive sterile sampling set, samples can easily be taken. Closing elements and pumping mechanisms are controlled by a control unit as part of a sampling control program.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: August 27, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Klaus Balschat, Reiner Spickermann, Josef Winter
  • Patent number: 8517967
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: August 27, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Keith Rosiello, Henrik Clausen
  • Patent number: 8517970
    Abstract: A flow control clamp having first and second legs disposed in a generally facing relationship. The clamp includes apertures receiving a flexible tube therethrough. The first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: August 27, 2013
    Assignee: Fenwal, Inc.
    Inventors: Jean-Marie Mathias, Gianni Di Stefani
  • Patent number: 8517969
    Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: August 27, 2013
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Norikazu Ishida, Hidetaka Nakayama
  • Patent number: 8511480
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8511479
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8506823
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: August 13, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8506513
    Abstract: A perfusion system that is easy to set-up, use and monitor during a bypass procedure includes at least some disposable components configured to communicate parameters to the perfusion system. An ultrasonic blood level sensor can be used to monitor a blood level or volume within a blood reservoir. The blood level sensor may be utilized in an integrated perfusion system in which the disposable components are configured, as noted above, to communicate with the perfusion system.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: August 13, 2013
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Ivan Rossi, Ivo Panzani
  • Patent number: 8500673
    Abstract: The disclosure pertains to a perfusion system that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system in which at least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system. In some embodiments, the disclosure pertains to a blood level sensor that can be used to monitor a blood level or volume within a blood reservoir. The blood level sensor may be utilized in an integrated perfusion system in which the disposable components are configured, as noted above, to communicate with the perfusion system. In some embodiments, the blood level sensor may be utilized with a perfusion system lacking communication with disposables.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: August 6, 2013
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Daniele Zanotti, Ivan Rossi, Ivo Panzani
  • Patent number: 8491854
    Abstract: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: July 23, 2013
    Assignee: King Saud University
    Inventor: Abdullah Khalid Al-Rasheed
  • Patent number: 8480606
    Abstract: A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Current filters are inefficient at removing small bubbles that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: July 9, 2013
    Assignee: Indian Wells Medical, Inc.
    Inventors: David W. Wieting, Jay A. Lenker
  • Patent number: 8460227
    Abstract: Apparatus and methods for producing interleukin-1 receptor antagonist and/or other prophylatically or therapeutically effective protein. Blood is obtained from a patient with a conventional syringe and then introduced into dual luer lock centrifuge tube. The dual luer lock centrifuge tube is provided with beads that are coated with a silanized coating. The container is then incubated and centrifuged. Subsequent to the incubation and the centrifugation, the serum containing autologous therapeutically active protein, such as IL-1Ra, in the container is withdrawn through the luer lock of the container, and injected back into the patient.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: June 11, 2013
    Assignee: Arthrex, Inc.
    Inventors: Christopher Bare, David O. Shepard
  • Patent number: 8449488
    Abstract: A blood component collection apparatus comprises a blood component collecting circuit which includes an anticoagulant line for feeding an anticoagulant and a line for collecting an initial flow of collected blood. In the blood component collection apparatus, air is intermediately present between the anticoagulant and the blood in the passage of a blood collection needle side line, after a priming operation is performed in which anticoagulant is supplied from the anticoagulant line toward the side of a centrifugal separator in the blood collection needle side line through a branch connector and after an initial flow collecting operation is performed in which the initial flow of blood is collected.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: May 28, 2013
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Makoto Hirabuki
  • Patent number: 8444620
    Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: May 21, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Barry F. Hecker
  • Patent number: 8439858
    Abstract: An arterial line blood filter for use in extracorporeal blood circuits during heart bypass surgery has, among other components, a housing with a cap portion, a base portion, and a generally cylindrical wall portion. The blood filter has a filter element disposed within the housing. An inlet is positioned at an upward angle with respect to the housing and includes an opening in the generally cylindrical wall portion in fluid communication with the inlet chamber. In some embodiments the position of the inlet limits the pressure drop and prime volume of the filter. According to one embodiment, the cap portion has an upwardly sloping inner surface and there is a vent in the cap portion. The inner surface of the cap portion can have a projection proximate the vent configured to limit immobilization of gaseous microemboli within the inlet chamber.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: May 14, 2013
    Assignee: Medtronic, Inc.
    Inventors: Trevor C. Huang, Alford L. McLevish, Joseph L. Kalscheuer, Roderick E. Briscoe
  • Patent number: 8435224
    Abstract: The invention relates generally to materials for facilitating the administration of dimethyl sulfoxide (DMSO) and related compounds. In one embodiment, the invention comprises a kit comprising items used for the safe and effective administration of DMSO. In another embodiment, the invention relates to indicating containers for holding or delivering DMSO.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: May 7, 2013
    Assignee: Abela Pharmaceuticals, Inc.
    Inventors: Harvey L. Claussen, Colette Cozean, Jack De La Torre
  • Patent number: 8425448
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: April 23, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
  • Patent number: 8414515
    Abstract: A conduit tube (90) that communicates with an intracardiac blood inflow port (50) and a liquid medicine injection port (72) and allows blood from the intracardiac blood inflow port and a liquid medicine from the liquid medicine injection port to flow into a cardiotomy section (2) is inserted from above downward in the cardiotomy section 2. A blood flow channel (93) for the flow of blood and a liquid medicine flow channel (95) for the flow of a liquid medicine are formed independently of each other in the conduit tube. With respect to the vertical direction, the lower end of a blood conduit tube portion (94) that forms the blood flow channel is located at a lower position than the lower end of a liquid medicine conduit tube portion (96) that forms the liquid medicine flow channel. This prevents the generation of negative pressure in the liquid medicine flow channel due to the flow of blood. It also reduces the resistance to the inflow of a liquid medicine into the cardiotomy section.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: April 9, 2013
    Assignee: JMS Co., Ltd.
    Inventors: Yutaka Katsuno, Minoru Tanaka
  • Patent number: 8409125
    Abstract: A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: April 2, 2013
    Assignee: Haemonetics Corporation
    Inventor: Alec D. Bobroff
  • Patent number: 8388567
    Abstract: In an apparatus for extracorporeal blood treatment, an extracorporeal circuit (6) is connected to a blood chamber (3) of a membrane device (2). A pump (10) displaces a priming fluid from a source of a priming fluid (9) to a drainage (11) for discharging the priming fluid. A control unit (13) is provided with a processor which controls the pump at a preset first flow rate value, and receives from a pressure sensor (12) a first pressure value, compares the first pressure value with a reference pressure value and, on the basis of this comparison, determines whether or not the extracorporeal circuit is of a pediatric type or of an adult type. The invention is particularly useful during a stage of readying a dialysis apparatus.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: March 5, 2013
    Assignee: Gambro Lundia AB
    Inventor: Paolo Rovatti