Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: A device for treating a fluid-like sample, in particular whole blood, with treatment fluid. The device comprises a tubular container with a first piston and a second piston, with a piston gap between them in which the treatment fluid is located in the initial position. The device further comprises an inlet port to which a capillary can be connected and an outlet port to which a filter can be connected.

Abstract: A portable hand-held blood sampling device having a self-filling capability includes a blood separation filter. The filter has a plurality of pores sized to permit passage of selected blood constituents such as blood plasma through the device. The device has a separated blood conduit that extends beyond the outlet of the device and is shaped for easy penetration into a self-sealing septum of a blood analyzer. An annular shield extends from the device outlet beyond the conduit to prevent inadvertent contact of the conduit by a user.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: A flow cytometer containg a device for sampling cellular material within a body. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, to maintain the sorted cells cells in a viable state, and to remove the marker from the marked cells. Two marker removal devices are used in the flow cytomter.

Abstract: An apparatus for collecting blood from a patient, comprising a collection vessel having a pleated, compressible body, the vessel having an inlet port adapted to be connected to a patient line for drawing blood from a patient; at least one, each outlet port adapted to be connected to a blood collection bag.

Abstract: The invention relates to a bag system for the cryopreservation of body fluids, that is blood, bone marrow or umbilical cord blood, the parts of the bag system being sterilized, [sic] separable from one another and liquids which permit and/or assist cryopreservation being located in the bag system and/or able to be introduced into the bag system in a sterile form, at least comprising:

Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a selected characteristic of the blood product.

Abstract: An intravenous drug access system. In one embodiment of the invention, the drug access system includes an IV bag having an inlet port and an outlet port, whereby the inlet port is a female luer integral therewith. The integral female luer fitting may be fitted with a sealed end cap including a male luer insert with a closed end. An alternative embodiment of the present invention comprises a discrete pre-molded connector made with a spike at one end and a female luer fitting at the opposing end. The spike is used to penetrate a standard IV bag through a conventional inlet port.

Abstract: Containers and conduits comprising a copolymer comprising ethylene and an acrylate are disclosed.

Abstract: A single-use system for separating blood and producing platelet concentrates includes an elongated container for receiving blood from a patient. The container has a movable plunger mounted within the blood container for expressing blood fractions separated during centrifugation of the container through a first port mounted at one end of said container, a second port mounted on the plunger, and a third port mounted on a plunger rod attached to the plunger.

Abstract: The present invention relates to a method for producing interleukin-1 receptor antagonists, a prophylatically or therapeutically effective protein. A syringe is filled with a body fluid and incubated. The prophylatically or therapeutically effective protein is then produced in the body fluid.

Abstract: A device for treating blood in an extracorporeal circuit comprising a venous blood reservoir having an inlet and an outlet, and a hemoconcentrator having a first inlet connector for the blood to be treated, a second outlet connector for the outflow of concentrated blood, and a third outlet connector for the outflow of the ultrafiltered liquid, wherein the hemoconcentrator is disposed within the venous blood reservoir and the hemoconcentrator and the venous blood reservoir are integrated into a single monolithic assembly, and wherein the hemoconcentrator comprises an enclosure containing structure suitable to concentrate blood.

Abstract: A fluid collection apparatus is provided that includes a housing configured for receipt of fluid and having a first surface which defines a needleless first mating portion. A holder has a first end and a second end configured to receive an evacuated tube. The first end defines a second mating portion on an outer surface thereof which is in fluid communication with the evacuated tube. The first mating portion sealingly engages the second mating portion to establish fluid communication therebetween. The first mating portion may have a locking surface that engages the second mating portion. The first end of the holder can include a needle hub supporting a needle cannula in fluid communication with the second mating portion and extending away from the first mating portion. In an alternate embodiment, an umbilical cord fluid collection apparatus includes a housing defining a cavity for receipt of at least a portion of an umbilical cord. The housing has a funnel surface which defines a male luer connector.

Abstract: An automatic system and method for the separation of blood into component parts includes a conically shaped collection and separation bag, component bags connected to the collection and separation bag, a sensor, valves to seal the connections between the component bags and the collection and separation bag, a centrifuge and a controller for controlling the process. Blood is placed in the collection and separation bag and is separated by centrifuging. The components are removed from the collection and separation bag either directly or indirectly by the centrifugal force into the component bags. Flow of the components is directed by automatic opening and closing of the valves in response to the position of the interface between the separated components determined by the sensor or elapsed time.

Abstract: This invention discloses a donor blood donation and sampling system including a donor needle adapted for drawing blood from a body, a blood collection bag coupled to a blood collection conduit which is coupled to the donor needle, a blood sampling conduit also coupled to the donor needle, and a sampling tube assembly arranged for selectable fluid engagement with the blood sampling conduit and for selectable clamping engagement with at least said blood collection conduit. A donor blood donation and sampling method is also disclosed.

Abstract: An intraoperative autotransfusion system and method of use. The system includes an autotransfusion device, a removable cassette, a cardiotomy reservoir, a container for holding washing fluid, and a reservoir for containing processed blood. The removable cassette includes a centrifugal cell, a peristaltic pump, and multiple clamps, each having fixed and sliding elements. The cassette has a housing and multiple ducts for connection to the cardiotomy reservoir.

Abstract: A system for collecting red blood cells (RBCs) and other blood components that reduces the need for human intervention. A disposable set is provided having a port, an RBC container, a centrifuge rotor having a variable total volume, and a filter, along with tubing connecting the port, the container, the rotor and the filter. A control unit is also provided and includes a spinner in which the rotor may be held, a flow-control arrangement for controlling flow among the various components of the disposable set, and an electronic controller. The whole blood is directed by the flow-control arrangement from the port through the tubing to the rotor. The rotor includes an elastic diaphragm, and the control unit's flow-control arrangement includes a pump or other device for applying a positive and negative pressure to the rotor's elastic diaphragm. The spinner rotates the rotor so as to separate the whole blood into plasma and RBCs.

Abstract: A vacuum assisted venous blood reservoir has a controller that can sense pressure within a sealed blood chamber. The controller regulates the amount of vacuum within the chamber to control the level of blood in the venous reservoir. A safety valve is included to prevent blood from entering the vacuum line.

Abstract: An integrated heat exchanger/reservoir for use alone or in combination in an extracorporeal blood circuit. The reservoir includes a hard outer shell topped by a lid with a venous blood inlet. Blood from the inlet enters an elongated annular heat exchange chamber defined between two vertical cylindrical walls within the reservoir. A plurality of heat exchange coils in the annular chamber provides an efficient heat transfer function with low prime volume requirement. Cardiotomy fluid may be first debubbled and then combined with the venous blood stream entering the heat exchange chamber. After passing through the heat exchange chamber, the blood passes through a series of filters before being pumped to the oxygenator.

Abstract: An autotransfusion system for collecting blood from a patient and reinfusing the blood back into the patient is disclosed. The system includes a collection unit, a manually operable portable suction evacuator removably connected to the collection unit, and a blood reinfusion bag removably connected to the collection unit. The collection unit includes a collection chamber that is oversized relative to the volume of blood that the unit is intended to contain, and an airflow port located and oriented in the collection chamber to prevent blood from leaking into the port when the collection unit is oriented upright or on its side. When connected to the patient, the collection unit and portable suction evacuator are maintained free of blood by enclosing them within a substantially transparent, flexible envelope. The envelope enables the unit and evacuator to be connected and set-up for proper operation while preventing blood from contacting the outer surfaces of the unit and evacuator.

Abstract: A device for supporting and displaying interrelated medical components, such as cardiopulmonary bypass circuit components. The device includes a rigid or flexible chassis having openings therein for receiving the components. A plurality of retainers, such as straps, hooks, or tabs, are provided adjacent the openings for releasably securing the components therein. The chassis may be formed of a thin, flexible polymer sheet having tabs cut therein and adapted to be bent out of the plane of the sheet for securely retaining the various components. The pre-arrangement of the components in close proximity greatly simplifies the task of setting up a particular medical circuit, and reduces the potential for error. For cardiopulmonary bypass circuits, the support device enables the tubing lengths to be reduced, thus reducing the prime volume of the circuit. The chassis is provided with apertures for mounting on rods in the operating room, which rods may extend from the operating table.

Abstract: The invention relates to a method and an apparatus for collecting and transporting liquids, for example blood, into one or more closed packages, for instance so called transfer bags (11, 12), or alternatively, directly transfering the blood into another liquid system, for instance a heart-lung machine, without any admixture of air or any other gas or gas mixture. The blood is collected without contact by human hand and without contamination of the blood and under sterile conditions. The apparatus comprises a suction nozzle (4) for sucking up the liquid or a liquid/air/gas mixture, a suction hose (5) for directing the liquid to a defoaming separator (7) for separating air from the liquid, and a recipient (8) in which the deacrated liquid is filtered and collected. When a certain volume has been collected, the liquid is directed without introducing air into said closed packages (11, 12) or communicated to another liquid system.

Abstract: A method for emptying a blood circuit of an apparatus for the extracorporeal treatment of blood after interrupting a treatment session, the apparatus comprising: a blood treatment device (4) having a fist and a second compartment (5, 6) separated from one another by a semi permeable membrane (7), an arterial pipe (8) connected to an inlet of the first compartment (5), a venous pipe (9) connected to an outlet of the first compartment (5) and a second end, a used liquid circuit (6, 21) having a drain pipe (21) connected to an outlet of the second compartment (6), whereby the method comprises the steps of: closing on itself a blood circuit (2) comprising the arterial pipe (8), the first compartment (5) of the blood treatment apparatus (4) and the venous pipe (9) in order to form a closed loop circuit, after the arterial and venous pipes (8, 9) have been disconnected from the vascular system of the patient, the blood circuit containing a liquid, transferring the liquid contained in the closed loop circuit into th

Abstract: A progressive filtration system for a chest drainage unit during continuous autrotransfusion comprising a gross filter for filtering incoming blood at the inlet portion of a collection chamber of a chest drainage unit and a conventional fine micron filter assembly located at the bottom portion of the collection chamber for refiltering collected blood prior to reinfusion of that blood back to the patient. The micron filter assembly includes a valve cap at the top portion of the assembly that functions as a plug to seal the top portion of the assembly and as a one way valve that permits reflux of later developing blood clots that might clog the tubing once the blood has already passed through the assembly. The valve cap is also adapted for sealing engagement with a drop tube that places the filter assembly in fluid flow communication with an outlet of the collection chamber located at the top portion of the chamber.

Abstract: A plastic medical article, such as a catheter or blood collection tube, is coated with a crosslinked hydrogel permanently bound to the inside wall of the tube. The hydrophilic surface provided by the hydrogel prevents adherence of blood components to the surface, and the permanent adherence of the hydrogel prevents its removal by blood.

Abstract: Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.

Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.

Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: An extraction device for a biological fluid with an additive solution in which it is desirable for the additive solution to be present in a particular volume proportion to the biological fluid. The volume proportion of the additive solution is determined by the ratio of cross sections of two tubes, one which supplies the biological fluid to a collecting bag and a second which supplies the additive solution to a collecting bag. The tubes are periodically constricted in constriction areas by a pump. The tubes are configured so that the additive solution and the biological fluid only mix downstream of the constriction areas, thereby reducing the risk of supplying the additive solution to the source of the biological fluid. In an exemplary embodiment the biological fluid is blood collected from a patient or donor and the additive solution is an anticoagulant and/or preservation solution.

Abstract: A loading system for providing a cell suitable for delivery of an agent to a vertebrate, the system comprise a loading module for loading a cell with an agent; and a sensitisation module in fluid communication with the loading module, the sensitisation module for sensitising a cell to an energy field, such that said cell is induced to release the agent upon exposure to said energy field. The system can be used to transform a cell, such as a red blood cell, into a delivery vehicle for delivering a therapeutic agent and/or an imaging agent to a vertebrate, and in particular, to a mammal, such as a human being.

Abstract: A holder for receiving a sampling tube of a blood sampling system is disclosed. The holder has an interior pocket which can be conformed from a closed position to an open position for receiving the sampling tube.

Abstract: The invention comprises a disposable tubing set (4) for connection to a rigid canister (2) that is maintained at a controlled reduced (vacuum) pressure.

Abstract: The subject matter of the invention is a flexible bag (1) intended to receive a biological fluid with a view to its centrifugation, comprising an external enclosure (2) formed by two sheets of flexible plastic (3, 3′) connected at their periphery (4) so as to define an internal volume (5) for the said fluid, the said external enclosure (2) being provided with at least one inlet (6) and/or outlet (7) orifice for the fluid, the said bag (1) also comprising means (8) for the temporary association of at least one component with the said bag (1), the said means (8) being disposed on the external enclosure (2), in which the temporary association means are assembled on the bag (1) on a part of the periphery (4) of the enclosure (2) and are arranged to allow the insertion of the said component between the said means (8) and the said enclosure (2) so as to provide temporary association during the centrifugation of the bag (1).

Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

Abstract: The invention relates to a placental blood collection line including a collection bag (1) in fluid communication with at least one collection needle (4, 5) via a first tube (2) associated with an inlet orifice (3) of the bag (1), said line further including a bag (6) containing a rinsing solution and which is connected to or is organized to be connected to said first tube (2) via a second tube (7). The invention also relates to a method of collecting placental 10 blood by using such a line.

Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: Plastic compositions, medical containers and methods for providing such compositions and containers are disclosed. The plastic compositions and the medical containers made thereof include a plastic resin, Vitamin E and a plasticizer. The plastic resin may be polymeric material such as polyvinyl chloride or polyolefin.

Abstract: A self-contained pack assembly includes all of the disposable components of an extracorporeal support circuit for cardiac bypass surgery. The pack assembly comprises a blood reservoir, a blood oxygenator, and a carrier for mounting the blood reservoir and blood oxygenator. One or more trays may be releasably attached to the carrier to serve as storage containers for coiled tubing used in the support circuit. Pre-made connections can also be formed between the tubing and the blood reservoir and blood and oxygenator as may be desired.

Abstract: A container for pathogen inactivating and storing blood or blood components, which includes multiple sub-compartments fluidly interconnected by an openable closure assembly. Each sub-compartment may contain a component necessary for pathogen inactivation or blood storage. Upon opening the openable closure assembly, the sub-compartments become one compartment and the components contained within each sub-compartment may be mixed together to form a combined solution for pathogen inactivation and/or storage of blood or blood components.

Abstract: A blood reservoir being capable of reducing damage to blood stored therein. The blood reservoir has a housing in the form of a box, and filtering and defoaming devices provided in the housing, i.e., a device for filtering and defoaming on blood suctioned from a surgical field (outside a heart), a device for filtering and defoaming on blood vented from the interior of the heart, and a device for filtering and defoaming on blood drawn off from a large vein. The vented blood flowing into the blood reservoir passes through a vented blood filtering member to be introduced into a blood storage space without contacting an antifoaming agent and foreign substances filtered off from the suctioned blood.

Abstract: A blood sampling system for obtaining blood samples from a fluid flow path is disclosed. The sampling system includes a container that can be isolated from the remainder of a blood processing set and allows for collection of a sample either before or after the blood donation.

Abstract: A composition including lecithin which is useful for defoaming liquids, such as blood. In one aspect of the invention the composition includes inorganic particles. In another aspect of the invention the composition includes a silicone.

Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: The venous reservoir accommodates variations in the total volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). It is connected between the patient and the arterial pump and serves as a compliance chamber. Venous drainage by gravity alone provides an inadequate rate of blood return during procedures such as minimally invasive cardiac surgery and bypass via femoral cannulation. In these cases the resistance of the venous cannula limits the maximum achievable flow. Vacuum augmented venous drainage (VAVD) is a technique that overcomes flow limitations by applying suction to the hard shell reservoir thereby increasing the pressure difference between the venous site and venous reservoir. VAVD allows for a decrease in the inner diameter of the venous line, thereby reducing prime volume, as well as the use of a smaller cannula that translates to an easier insertion, a better surgical view, and a smaller surgical incision.

Abstract: An extracorporeal circulation apparatus capable of maintaining hypothermia for a prolonged period when used in the selective cooling method. The extracorporeal circulation apparatus used in the selective cooling method includes (1) a diluent supply unit for cooling a diluent and metering the diluent into a blood vessel; (2) a blood concentration unit for metering a diluted blood out from a blood vessel and concentrating the diluted blood thus drawn out by filtering the diluted blood; and (3) a blood supply unit for heating the concentrated blood and metering the concentrated blood into a blood vessel, wherein a flow rate of the injected diluent flow rate, Vd and a flow rate of a filtrate, Vb are so controlled that a relationship 0.1 Vd≦Vb≦Vd is maintained.

Abstract: Systems and methods collect leukocyte reduced blood components, including plasma that is free or virtually free of cellular blood species, such as red blood cells, platelets, and leukocytes.

Abstract: A self-contained pack assembly includes all of the disposable components of an extracorporeal support circuit for cardiac bypass surgery. The pack assembly comprises a blood reservoir, a blood oxygenator, and a carrier for vertically mounting the blood reservoir and blood oxygenator. Trays may be releasably attached to the carrier to serve as containers for coiled tubing used in the support circuit.

Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.

Abstract: A gross filter in a drainage device for filtering fluids drained from the pleural cavity of a patient comprising a filter body having a first side panel, second side panel, back panel and bottom panel that assemble to form a generally box-shape filter with open front and top portions. The gross filter is located in the first of two subchambers that comprise the collection chamber. The filter body further comprises a filter screen sized for filtering gross particulates, such as blood clots, that may become entrained in fluid drained from a patient. The gross body is configured so as to permit the further filtering of fluids when blood clots have formed and blocked the filter screen of the filter's bottom panel from fluid flow therethrough, thereby allowing uninterrupted filtering of blood into the collection chamber through the first and second side panels instead.