Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.

Abstract: One or more embodiments of the disclosure relate, generally, to a diabetes management system. Such a diabetes management system may include a flash glucose monitor and a user interface. The user interface may be configured to display one or more of graphical representations of glucose values and value representative of glucose measurements, and to change values displayed responsive to user interaction with the user interface.

Abstract: A system for mass vaccination includes a plurality of portable electronic injectors, a mobile process manager and a database. Each portable electronic injector includes at least one needle to administer a measured amount of at least one vaccine to a body skin/tissue and an indicator system to provide an indication when either an injection error occurs or when a vaccination indication is required. The mobile process manager is in wireless communication with the plurality of injection devices and controls a mass vaccination. The process manager transmits task data to all injection devices in parallel via WI-FI, receives the vaccination indications from each injector in real time, also receives injection errors and vaccination process data, alerts a vaccination process overseer generally in real-time of the errors and transmits the injection data from each injector via cellular and/or internet transmission to the database.

Abstract: A stylus includes a housing, a tip portion at an end of the housing, and a control module within the housing, with the housing including a shape-changeable portion, and the control module to generate a first signal in response to the shape-changeable portion of the housing having a first effective cross-sectional area and generate a second signal in response to the shape-changeable portion of the housing having a second, different effective cross-sectional area.

Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.

Abstract: Provided is a micro-jet drug injection device comprising: a pressure chamber having a pressure driving liquid hermetically filled therein; a drug chamber having a micro nozzle defined in a wall; an elastic membrane elastically expandable and restorable and to separate the pressure chamber from the drug chamber; an energy-focusing unit concentrating energy on the pressure driving liquid in the pressure chamber; and the storage unit supplying the drug solution therein into the drug chamber through a drug supply channel. The drug chamber has a partial inner space defined therein. The partial inner space is in fluid communication with the drug supply channel and is partially defined by the membrane. A nozzle closure is disposed inside or outside the drug chamber. The nozzle closure blocks inflow of air outside the micro-nozzle into the partial inner space after the elastic membrane has expanded and before elastic recovery of the membrane is completed.

Abstract: A closed and tamper-evident sealed container, including a fluid transport adapter. The adapter provides for sterile fluid communication between a fluid source outside the container and the container interior when adapter is open. The adapter is adjustable to a closed position wherein the fluid communication ceases. An alternative to the adapter utilizes a sampling attachment that fits into tight engagement with the lid which comprises at least one septum. Coupling the sampling attachment to the lid either causes sharps in the attachment to penetrate the at least one septum or to displace the edges of the septum inward to form a fluid communication with the container interior while the lid remains sealed closed. Other variations include a rotatable sampling attachment, a container with a displaceable bottom wall to act as a syringe and a large volume (e.g., 1500 mL) sealed ampoule which also uses a sampling attachment.

Abstract: A manual subcutaneous jet injector includes an injector body having an injection portion provided with an injection system including an injection fluid volume fluidically connected to a subcutaneous injector outlet, and a pumping portion. The pumping portion includes an interior chamber having a pumping portion and a pressure chamber portion fluidically connected to the injection fluid volume. A manually operated injector pump is arranged in the pumping portion. At least one one-way valve is arranged between the pumping portion and the pressure chamber portion, the one-way valve including an inlet end and an outlet end. A piston is arranged in the pumping portion at the inlet end of the one-way valve.

Abstract: The dental instrument includes a syringe and a topical anesthetic dispenser that is slidably attached to the syringe. The topical anesthetic dispenser can include a dispenser plunger, a dispenser barrel that slidably engages the dispenser plunger, a dispenser tube, and a needle cover affixed to the dispenser tube. The syringe can include a syringe plunger, a syringe barrel that slidably engages the syringe plunger, and a hollow needle having a beveled front end and a rear end extending toward the syringe barrel. A first carpule containing topical anesthetic can be loaded in the dispenser barrel. A second carpule containing injectable anesthetic solution can be loaded in the syringe barrel.

Abstract: Embodiments of the present invention generally relate to methods of knee rehabilitation. Embodiments generally include the use of viscosupplementation delivered intra-articularly in conjunction with rehabilitative therapy and an unloading knee brace. The injection of the viscosupplementation is guided such that the entire dose is delivered to the joint and can flow tricompartmentally.

Abstract: A micro-needle roller (MNR) infusion system for transdermal delivery of active agents, skin-care products, and other topical formulations is described herein. The infusion system of the instant invention comprises a needle roller assembly with 0.25 mm needles enclosed in a housing with a vacuum line and a disposable cartridge having the active agent, the skin-care product or the topical formulation. The vacuum delivers the fluid and ensures that the skin is being pulled against the needle wheel surface to ensure that penetration of the needles is complete into the skin, simultaneously the fluid is flowing to the wheel and to skin as it rolls along with the outer housing of the tip cap assembly being occluded to the skin surface.

Abstract: Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial.

Abstract: A pistol-shaped needleless injector includes a readily replaceable barrel (36) in the front end thereof facilitating adjustment of the dosage administered using the injector. A disposable nozzle (98) mountable on a holder (97) extending outwardly from the front discharge end of the barrel (36) provides an indication that the nozzle (98) has been used and should be discarded.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: A device to be used with a medical administration device includes administration driver for administrating a prescribed dose of medicament; and a mechanical dose setter for setting a prescribed dose of medicament to be administered, including a mechanical indicating member fixedly connected to the administration driver for indicating the prescribed set dose. The device includes a mechanical dose information device for registering the prescribed dose of medicament to be administered including a mechanical information member adjustable to display that the prescribed dose to be administered is correct and inter-connected to said mechanical indicating member such that when the prescribed dose is set, this is indicated positively by indications on the mechanical information member.

Abstract: An assembly for a drug delivery device comprises a housing having a proximal end and a distal end, a dose button configured to be moved with respect to the housing for setting and delivering a dose of a drug, and a resilient setting member. For a dose delivery movement, the dose button is arranged to be moveable in the distal direction with respect to the housing from a dose delivery position, thereby deforming the resilient setting member to store energy in the resilient setting member. The assembly is configured to use the energy stored in the resilient setting member for a dose setting movement to move the dose button in the proximal direction with respect to the housing into the dose delivery position. Furthermore, a drug delivery device is provided.

Abstract: A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.

Abstract: The present invention relates to a medicament delivery device comprising an elongated housing arranged to contain a medicament container which medicament container contains a number of doses; a dose counter mechanism comprising a dose drum arranged with dose indicia on its outer surface and visible through a window on said housing; a rotatable driver connected to said dose drum; a plunger rod arranged to act on said medicament container for expelling a dose of medicament; an actuation mechanism connected to said rotatable driver and to said plunger rod when said medicament delivery device is actuated; wherein said dose drum is arranged with internal threads, in engagement with corresponding threads on said driver, wherein said threads have a certain pitch; wherein said dose drum is also arranged with external threads in engagement with corresponding threads arranged fixed in relation to said housing, wherein said threads have a certain pitch; and wherein the pitch of the threads between the dose drum and fixe

Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.

Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Abstract: The invention provides a jet expelling assembly comprising a reservoir and an impulse chamber assembly. The impulse chamber assembly comprises a chamber portion defining a cavity having a general axis, a piston received in the cavity along the general axis and comprising a fluid inlet, thereby defining a variable-volume impulse chamber with an outlet nozzle. The inlet comprises a conduit adapted to slidably engage a reservoir outlet during relative movement therebetween. The chamber portion is arranged stationary relative to the reservoir, whereby expelling an amount of drug from the reservoir to the impulse chamber via the inlet causes the piston to move towards the reservoir, the impulse chamber thereby receiving the expelled amount of drug.

Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.

Abstract: The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.

Abstract: A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

Abstract: The invention relates to a medicament container for a liquid medicament, the medicament container comprising a bag with an outlet, the bag being compressible or shrinkable by subjection of at least a part of the medicament container to an energy source.

Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.

Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.

Abstract: A urine capturing assembly includes a sleeve that has an upper edge, a lower edge and a perimeter wall extending between the upper and lower edges. The upper and lower edges define openings in the sleeve. A penis is positionable in the sleeve to direct urine from the penis toward the lower edge. A pouch has an open top end. The pouch is integrally coupled to the perimeter wall and the top end is positioned adjacent to the upper edge of the sleeve. A scrotum is positionable in pouch through the top end. A conduit is fluidly coupled to and extends between the sleeve and the pouch to direct urine held in the pouch into the sleeve. A collection bag is fluidly couplable to the lower edge of the sleeve to collect and retain urine.

Abstract: A drug pressuring and delivering system has an internal quantitative pusher for providing stable and precise drug delivery, and a drug pressuring and delivering device for introducing a compression gas for pressuring and ejecting a drug into an atomized drug. The quantitative pusher adopts a bidirectional motor for driving a screw rod to rotate forward or reversely to push the push rod forward or backward, such that the drug is delivered through a solenoid and a drug delivering needle in a cylinder drug delivering pipe and then quantitatively delivered to a drug delivery pressuring tube. In addition, an introduced mainstream gas in the drug delivery pressuring tube forms a gas-liquid mixing and pressuring action to achieve the precisely quantitative and uniform atomization high speed ejection function. Also, all members of the invention can be assembled/disassembled, so that the damaged or contaminated members can be detached, cleaned or replaced.

Abstract: A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11). The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement.

Abstract: A method and apparatus for delivering therapeutic or diagnostic agents as a low pressure high velocity spray into tissue. According to the particular desired spray characteristics, the spray may be generated via the combined use of pressure atomization and electrostatic spray charging, or via the combined use of pressure atomization and electrostatic atomization. Particle velocity, spray flow-rate, and spray dispersion are further controlled via electrostatic means.

Abstract: An injection device of the kind having a main housing (4) is disclosed and includes a drive mechanism (42) to expel selectively a dose of medicament from a medicament cartridge (40) through a needle unit (22) and an electronic control unit to control the drive mechanism (42). The injection device further comprises a prime button (26) which causes a prime signal to be sent to the electronic control unit, the electronic control unit actuating the drive mechanism (42) to expel a predetermined small dose of medicament on receipt of the prime signal. In this way removal of entrapped air from the medicament cartridge (40) is obtained.

Abstract: A device for storing and administering active substances, including a plurality of reservoirs for respectively accommodating at least one active substance. The reservoirs are disposed in a radial manner with an end face facing the direction of the center of the device. A mechanism is mounted in the device to open and close the reservoirs. A needle-free injection device delivers at least one active substance to a user.

Abstract: A programmable injection device, comprising: a nozzle comprising a nozzle head with a fluid input hole and a distinct injection hole, the nozzle head accepts a dose of fluid from the fluid input hole to be injected into the skin of a patient through the injection hole, without use of a needle, a fluid capsule that is connected to said nozzle head and is adapted to provide the nozzle head with multiple doses of fluid for successive injections, without replacing the fluid capsule, an injection head that is adapted to have said fluid capsule and said nozzle head mounted onto it, comprising a first mechanism adapted to forcefully push a dose of a programmable amount of fluid from said fluid capsule to said nozzle head and a second mechanism for injecting by an programmable pressure said dose of fluid from said nozzle head into the skin of a patient in at least one of a programmable velocity or a programmable pressure applied to the skin surface.

Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

Abstract: A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.

Abstract: A device for administering a fluid product, the device including a first housing part provided with a receiver for the product, a second housing part detachably connectable to the first housing part, a piston rod held such that it can be displaced for the exertion of an emptying movement, an actuatable or releasable drive element for the piston rod, a coupling element including a coupling input element that couples the drive element to the piston rod in a coupling engagement, transmits a driving force of the drive element to the piston rod, and triggers the emptying movement, and a decoupling element displaceably connected to the second housing part and coupled to the first housing part such that it is displaced, by a movement of the housing parts in relation to each other when the housing parts are separated into a decoupling position wherein the piston rod is decoupled from the coupling input element.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: Needle-free injection devices having a drive assembly to provide an operative force to effect an injection and a dosing assembly to prepare the device for a subsequent injection. In some embodiments, the dosing assembly is configured to transfer injectate from an injectate source to the injectate assembly. In some embodiments, a portion of energy available to the drive assembly urges the injectate towards the injectate assembly. In some embodiments, the device includes a nozzle assembly having one or more ports.

Abstract: A needle-less fluid injection device, including, a nozzle head with an injection hole for accepting a dose of fluid to be injected into the skin of a patient, a fluid capsule that is connected to said nozzle head and provides the nozzle head with one or more doses of fluid for injection, an injection head for mounting the fluid capsule and the nozzle head; including a first mechanism for releasing a dose of fluid from the fluid capsule to the nozzle and a second mechanism for injecting the dose of fluid from the nozzle into the skin of a patient.

Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Abstract: An injection device comprising a housing and a dose setting mechanism including a dose setting element. Contrary to prior art injection devices, the dose setting element can only be set at a few different dose settings. This is established by forming the dose setting element as a rotatable dish concealed within the housing and having a number of projections projecting outside the boundaries of the housing through a slot in the housing. A dose is set by activating a projection which in addition provides the user with a tactile guidance. Usually one projection is provided for one dose setting limiting the number of doses to be set to the number of projections.

Abstract: A device for storing and administering active substances, including a plurality of reservoirs for respectively accommodating at least one active substance. The reservoirs are disposed in a radial manner with an end face facing the direction of the center of the device. A mechanism is mounted in the device to open and close the reservoirs. A needle-free injection device delivers at least one active substance to a user.

Abstract: Needle-free injection devices and drug delivery systems are disclosed. The needle-free injection devices may include a drug delivery system, a power source, an activation system, and a disabling element. The drug delivery system may include a needle-free syringe and a drug storage system. The needle-free syringe may include a plunger slidably disposed within an injection chamber. The injection chamber may include an injection orifice, and the plunger may be configured to expel a volume of fluid from the injection chamber through the injection orifice. The drug storage system may include a storage chamber and an outlet. The drug storage system may be frangibly connected to the needle-free syringe with the outlet proximate to and fluidly connected with the injection orifice. The drug storage system may be configured to inject a fluid from the storage chamber through the outlet, through the injection orifice, and into the injection chamber.

Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.

Abstract: A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11). The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement.

Abstract: A lock for an injection device including a threaded rod, wherein the lock includes one of an anti-rotation or claw-type securing element engageable in cooperative anti-rotation elements or claws of the injection device to prevent rotation of the threaded rod relative to the injection device.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.