Abstract: A needleless pain-free injection device according to the present disclosure includes a valve body, a valve member provided in an internal space of the valve body and airtightly sliding along the valve body, a liquefied gas container communicating with the internal space of the valve body and detachably coupled, at one end thereof, to the valve body, an operating knob provided on the exposed end of the valve member, a cylinder body coupled to one side of the valve body and having an internal space, a piston member provided such that one end thereof slides in the internal space of the cylinder body and having a piston rod, an injection unit provided with an injection piston rod coupled to the piston rod, and a gas passage forming means for selectively establishing and blocking the communication of the valve body and the cylinder body with outside air.

Abstract: A self-retracting syringe has an injection assembly and a retraction assembly. The injection assembly has a housing, a spring rest, and a spring that is restrained initially in compression between the housing and the spring rest. A plunger rod is disposed inside the coil of the spring. A coupler in contact with the spring rest and the plunger rod releasably couples the plunger rod to the spring rest. When a latch is released, the plunger rod moves distally to urge a seal forward, which seal movement causes a hypodermic needle to extend and a medicament to be expelled through the hypodermic needle. A retraction assembly returns the hypodermic needle into the syringe body after the medicament is expelled. Embodiments of retraction assembly provide an inlet through which fluid may be introduced into the syringe through said hypodermic needle. Methods for filling the syringe are also described.

Abstract: An adapter for use with an injection device includes a first end, a second end and a first longitudinal axis extending from the first end and the second end. The adapter also includes a chamber defined by a sidewall between the first end and second end and a nozzle having a passageway extending through the sidewall, the passageway having an input at the chamber, an output at an outer surface of the body and a passageway axis extending from the input to the output, the passageway axis being angularly offset from the longitudinal axis of the channel. A cartridge can include such an adapter.

Abstract: An apparatus includes a substantially cylindrical body including an end portion having rounded edges and at least one opening. The apparatus further includes a nub integrally formed with the substantially cylindrical body and extending from the end portion proximate to the at least one opening. The nub includes a substantially rounded end.

Abstract: An automatic applicator for liquid pharmaceutical preparations, particularly for multiple injection application of set doses of a medicine from an exchangeable container is provided. The automatic applicator includes a body housing connected to a housing of an exchangeable container with a medicine having a plunger, the said plunger being displaced only linearly by an integrated driving unit, suitable for immobilizing, driving, leading linearly and blocking rotation of the plunger, driven via a double action clutch, by a tensioning spring situated in the body housing, the spring tensioned by a rotary hand-dose-setting ring via the double action clutch, wherein the driving unit is activated by a trigger unit and a dose is indicated by an indicating arrangement. The automatic applicator further includes at least one block key placed in an upper part of a ratchet barrel, collaborating with at least one key placed in an internal part of the body housing.

Abstract: The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing.

Abstract: The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing.

Abstract: A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.

Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: The present invention relates to a syringe (20) defining a reservoir (21) for containing a liquid and comprising an end-piece (10) encompassing a channel (11) providing a passageway for the transfer of the said liquid, characterized in that the said channel (11) comprises two portions, a first portion (12) and a second portion (13), the said first portion (12) extending from the free distal end (14) of the end-piece (10) in the direction of the reservoir (21), and the said second portion (12) extending between the first portion (12) of the channel (11) and the proximal end (15) of the end-piece (10) and connecting the said first portion (12) to the reservoir, the said first portion (12) having an average diameter that is greater than the average diameter of the said second portion (13).

Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.

Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.

Abstract: A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.

Abstract: The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.

Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.

Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.

Abstract: A urine capturing assembly includes a sleeve that has an upper edge, a lower edge and a perimeter wall extending between the upper and lower edges. The upper and lower edges define openings in the sleeve. A penis is positionable in the sleeve to direct urine from the penis toward the lower edge. A pouch has an open top end. The pouch is integrally coupled to the perimeter wall and the top end is positioned adjacent to the upper edge of the sleeve. A scrotum is positionable in pouch through the top end. A conduit is fluidly coupled to and extends between the sleeve and the pouch to direct urine held in the pouch into the sleeve. A collection bag is fluidly couplable to the lower edge of the sleeve to collect and retain urine.

Abstract: A method of producing a particle cassette for a needleless syringe device which alleviates problems of providing a chamber for the confinement of particles which is hermetically sealed from the environment. A predetermined force is applied in the longitudinal direction to push first and second cassette parts together so as to cause plastic deformation of a portion of the first cassette part so as to create said hermetically sealed chamber. The cassette parts are preferably made of PETG and have bonded thereto rupturable membranes preferably made of PET. The sealing is preferably achieved at the end of a protrusion on the first cassette part which is tapered and which interacts with the membrane of the second cassette part.

Abstract: A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: A device for storing and administering active substances, including a plurality of reservoirs for respectively accommodating at least one active substance. The reservoirs are disposed in a radial manner with an end face facing the direction of the center of the device. A mechanism is mounted in the device to open and close the reservoirs. A needle-free injection device delivers at least one active substance to a user.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least cylinder/piston unit (100) filled with an injection solution, at least one piston-actuating ram, and at least one trigger unit. The spring-loaded piston-actuating ram is supported on the housing via at least one support rod (21), wherein the contact zone located between an individual support rod and the piston-actuating ram represents a wedge gear pairing that forces the respective support rod radially outwards. The support rod or support rods bear on at least one activation element (82) that is mounted on the housing and positioned in a locking position. The activation element can be brought by displacement into a triggering position that releases the piston-actuating ram.

Abstract: A disposable injector with a housing that has at least one compression hook, which has at least one support surface respectively in the region of its free end. A piston-actuating plunger rests on the support surface. The locking position of the compression hook is secured by an actuating element positioned in a locked position. The actuating element has a locked position, in which it rests securely on a sealing cap. The actuating element has a triggering position, which effects lateral retreat of the compression hook when the piston-actuating plunger is released.

Abstract: A disposable injector with a housing (10) in which at least one mechanical spring energy accumulator (50), at least one cylinder-piston unit (100), at least one piston-actuating ram and at least one release unit are arranged. The housing has at least one draw hook (21) which has at least one supporting surface in the region of its free end. The piston-actuating ram bears against the supporting surface. The blocking position of the draw hook is ensured by a release element positioned in a blocking position. The release (82) has a release position which brings about an inevitable lateral retraction of the draw hook—with the piston-actuating ram being released.

Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

Abstract: A kit of parts for use in the manufacture of a particle cassette for a needleless syringe device. The kit may include a first cassette part having a first rupturable membrane sealed thereto and a second cassette part having a second rupturable membrane sealed thereto. The first and second cassette parts may be arranged to be attachable together so as to create a chamber for the confinement of particles between the first and second membranes. The first and second cassette parts may be substantially annular and the first cassette part defines a receptacle for receiving particles. The second cassette part may be attachable concentrically around or inside the first cassette part.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A breast shield support is provided which in one embodiment includes a central harness body adapted to hold a breast shield. The central harness body may include three spaced straps connected to or extending from the central harness body. Each of the harness straps includes a clip, for example, for attaching a respective strap to a portion of a nursing brassiere and at least one strap includes a plurality of protrusions or grooves formed along the length of the strap for engaging a respective clip and permitting the clip to be easily adjusted and held in a desired position along the length of the strap.

Abstract: A method of producing a particle cassette for a needleless syringe device which alleviates problems of providing a chamber for the confinement of particles which is hermetically sealed from the environment. A predetermined force is applied in the longitudinal direction to push first and second cassette parts together so as to cause plastic deformation of a portion of the first cassette part so as to create said hermetically sealed chamber. The cassette parts are preferably made of PETG and have bonded thereto rupturable membranes preferably made of PET. The sealing is preferably achieved at the end of a protrusion on the first cassette part which is tapered and which interacts with the membrane of the second cassette part.

Abstract: A medicament dispensing device including a substantially rigid carpule body which has a dispensing end and an actuation end opposite the dispensing end. The carpule body is substantially tubular and thus defines a carpule bore. The device further includes a plunger operatively disposed within the carpule bore having a plunger actuator near the actuation end of the carpule body and a plunger tip opposite the plunger actuator. The plunger tip and an orifice at the dispensing end of the carpule bore define a medicament volume which may be loaded with a medicament selected to achieve specific therapeutic goals. The carpule body may also include a wound depth scale. The depth scale is typically associated with the dispensing end of the carpule body. Similarly, the medicament dispensing device may include a dosage scale. Also disclosed are methods of dispensing medicaments.

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: A needleless injection device with a lower part receiving the agent cartridge and an upper part providing the energy needed for injection. The upper part contains energy store units capable of elastic form-change. Rotating the lower part in relation to the upper part causes the lower part to move along the longitudinal axis toward the upper part, resulting in the tension state of the energy storage structural elements. Furthermore, the device has a lock maintaining the tension of the energy storage units and component to release the lock. Among the energy storage structural parts there is at least one start unit capable of storing at least 60% of the total discharge energy (pressure), with the reversible elastic distortion not exceeding 25% of the internal length of the agent cartridge. The device has separate structural components for stretching the start unit and limiting its relaxation.

Abstract: A device for the dosed administration of an injectable product, including a housing with a receptacle for the product and a drive mechanism movable via a dosing element supported displaceably in the housing, wherein the drive mechanism includes engagement elements situated together in groups, the distance between the groups corresponding to a dosing amount of the injectable product and the distance between the engagement elements corresponding to a priming amount of the injectable product, and wherein the dosing element is coupled to the drive mechanism so that the dosing element at one time interacts with a group of engagement elements to administer the dosing amount and at another time interacts with an engagement element to release the priming amount.

Abstract: Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes) attached to biaxial or coaxial injection cannula(s) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula(s). In some embodiments, the injector devices of the present invention may include a first set of finger grips at a first location and a second set of finger grips at a second location. Also, in some embodiments, the injector devices of the present invention may include depth slops for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the present invention may include refill manifolds with attached syringes or other reservoirs containing the component substances to facilitate refilling of the injectors.

Abstract: An ampoule guide and a drug solution administering unit having excellent stability. An ampoule guide (30) is provided with a hollow cylindrical guard (31) at a tipping portion and which accommodates therein an ampoule (20); a drug solution administering unit provided with an ampoule guide (30) which is provided with a hollow cylindrical guard (31) at a tipping portion and which accommodates therein an ampoule (20), a gasket (40) which is set within the ampoule (20) for accommodating and pushing out a drug solution, and a plunger activating portion (50) provided with a push-out mechanism for pushing out the gasket (40); and the like.

Abstract: An ampoule which is hard to crack on a barrel while increasing cleavability required for a hermetical container end. An ampoule (20) is provided with a front edge portion (1), a main body (2), a connection (3), and a joint (4), wherein a hermetical container end (10) which includes the front edge portion (1), the joint (4) and the connection (3) is formed separately from the main body (2), and the joint (4) breaks when a force is applied from a lateral direction with respect to the central axis (5), so that a head portion of the connection (3) which is circular truncated cone shaped is exposed and the space portion (13) of the connection (3) becomes an open end.

Abstract: An injector system (100) for needleless, high pressure delivery of a medicament, the system comprising: an injector (102) having an injector piston (106) movable with in an injector body (104), a medicament container having a reservoir piston (119) movable in a reservoir (116), a fluid connection (118) interconnecting the injector body and an outlet (120) of the reservoir; and wherein the fluid connection is arranged such, with respect to the injector body, that upon movement of the reservoir piston towards a distal end, the medicament contained in the reservoir is pressurised whereby the injector piston is moved away from an initial position and the injector chamber is filled.

Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, said jacket completely enveloping the base in the longitudinal axial direction.

Abstract: A method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject are disclosed. The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle accelerates the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle.

Abstract: A wearable infusion device comprises a component that causes a piston to move an incremental distance to cause the device to dispense a dose of medicament from a reservoir.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A fluid injecting device (30) generally including a fluid delivery assembly (32) and a needle-free injecting assembly (34). The fluid delivery assembly (32) delivers or transfers the fluid medicine from a cartridge (40) into the needle-free injecting assembly (34) for injecting into a patient. A drive train (112) applies a force to a piston (64) inside the cartridge (40) during the delivery of the fluid to the needle-free injecting assembly (34) to prevent adhesion or static friction between the piston (64) and the cartridge (40). In addition, sensors can be used to help ensure the proper amount of dosage is transferred to the needle-free injecting assembly, conserve power, reduce leakage during disassembly, among other functions.

Abstract: A kit of parts for use in the manufacture of a self-contained particle cassette for a needleless syringe device. In an exemplary embodiment, the kit includes a first cassette part having a first rupturable membrane sealed thereto, and a second cassette part having a second rupturable membrane sealed thereto. In this exemplary embodiment, the first and second cassette parts are arranged to be attached together by a method other than heat sealing so as to form the self-contained particle cassette and so as to create a chamber for the confinement of particles between the first and second membranes.

Abstract: The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid active agent that is to be injected, and an active agent injection system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: The present invention discloses a medical injector and medicament loading system for use therewith. The medicament loading system includes cap for a medicament cartridge. The cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper. The medical injector according to the present invention includes the medicament loading system, i.e., a cartridge assembly, a needle free syringe assembly, and a power pack assembly.

Abstract: A method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject are disclosed. The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle accelerates the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle.