With Flow Control Means (e.g., Check Valves, Hydrocephalus Pumps, Etc.) Patents (Class 604/9)
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Patent number: 9186274Abstract: A drainage apparatus is disclosed to reduce intraocular pressure in an eyeball that includes an anterior chamber having aqueous humor disposed therein, a cornea and a surrounding marginal limbus by which the cornea is continuous with a scleral layer and a conjunctival layer disposed on an exposed surface of the eyeball and under eyelids, the apparatus comprising an inlet assembly configured to be disposed at the anterior chamber of the eyeball, an outlet assembly configured to be disposed at the external surface of the eyeball, the assembly having a central chamber, a tube extending between the inlet and outlet assemblies and configured to promote fluid communication between the inlet and outlet assemblies, and control means disposed within the outlet assembly for controlling a flow of aqueous humor through the tube from the anterior chamber of the eyeball to the external surface of the eyeball, the control means further comprising a replaceable filter disposed within the central chamber of the outer member tType: GrantFiled: August 25, 2009Date of Patent: November 17, 2015Assignee: CAMRAS VISION INC.Inventors: Carl B. Camras, Nancy Louise Camras, Lucinda J. Camras
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Patent number: 9173984Abstract: The present invention includes various devices and methods for ventricular assist. In one embodiment, the present invention is a ventricular assist device for intraventricular placement inside a heart of a mammalian subject, the device including a ring configured to be mounted adjacent an apex of the patient's heart; a rigid elongate member having a proximal and distal end; and a pump having a housing and an outflow cannula having a tip, the tip having a distal end projecting through an aortic valve of the subject's heart, wherein the ring and the pump are connected to the rigid elongate member remote from one another so that the rigid elongate member maintains the pump in position relative to the ring.Type: GrantFiled: August 28, 2014Date of Patent: November 3, 2015Assignee: HeartWare, Inc.Inventors: Jeffrey A. LaRose, Charles R. Shambaugh, Jr., Steve A. White, Daniel Tamez
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Patent number: 9168172Abstract: A process for treating glaucoma whereby the treatment can be accomplished by the use of medication or by surgery, or both, in order to control or prevent the occurrence of glaucoma. The optic nerve is aligned within and between two distinct pressurized spaces and within the dural sheath, the intraocular space and the intracranial space having an intraocular pressure (IOP) and an intracranial pressure (ICP), respectively. Medicine can be administered to raise the intracranial pressure in order to reach a desirable lower translaminar pressure difference across these two pressurized spaces which are separated by the lamina cribrosa in order to treat glaucoma. An alternate closely related mode of the treatment process is the implanting of a shunt substantially between the intraocular space and the intracranial space in order to beneficially equalize pressure differentials across the intraocular space and the intracranial space.Type: GrantFiled: February 25, 2009Date of Patent: October 27, 2015Inventor: John P. Berdahl
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Patent number: 9155827Abstract: A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.Type: GrantFiled: February 17, 2011Date of Patent: October 13, 2015Assignee: FLOW FORWARD MEDICAL, INC.Inventor: F. Nicholas Franano
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Patent number: 9155653Abstract: A control valve for a fluidic system is disclosed. The control valve comprises a housing and a flow control membrane is disclosed. The flow control membrane is anchored within the housing to form a reference chamber on a first side of the membrane and a fluid flow channel on a second opposing side of the membrane. The fluid flow channel selectively opens and closes to permit fluid to flow from the inlet to the outlet, and the membrane is configured to control flow through the channel from the inlet to the outlet by deflecting in response to pressure differentials of the reference chamber pressure and the fluid flow channel pressure acting across the membrane.Type: GrantFiled: February 14, 2012Date of Patent: October 13, 2015Assignee: Alcon Research, Ltd.Inventor: Leslie A Field
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Patent number: 9144676Abstract: A magnetic alignment system that can form part of a cochlear implant system. The magnetic alignment system prevents substantial movement of a magnet of an implanted component during an MRI procedure or allows for easy removal of the magnet to facilitate the MRI procedure.Type: GrantFiled: August 28, 2012Date of Patent: September 29, 2015Assignee: Cochlear LimitedInventors: Peter Gibson, Roger Leigh, Frank Risi, David Walker
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Patent number: 9138568Abstract: An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.Type: GrantFiled: May 19, 2011Date of Patent: September 22, 2015Assignees: ShuntCheck, Inc., The Children's Medical Center CorporationInventors: Marek Swoboda, Matias Gabriel Hochman, Mark Evan Mattiucci, Frederick J. Fritz, Joseph R. Madsen
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Patent number: 9138518Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.Type: GrantFiled: January 6, 2012Date of Patent: September 22, 2015Assignees: THORATEC CORPORATION, THE PENN STATE RESEARCH FOUNDATIONInventors: Robert L. Campbell, Jeremy J. Koncoski, Thomas M. Mallison, Mark W. McBride, Daniel Metrey, Eric C. Myer, Kevin J. Powell, Adam Roslund, Daniel A. Walters, William James Repka, Phyllis Yuen
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Patent number: 9125723Abstract: Methods and devices for adjusting or configuring the flow rate of an intraocular shunt are provided whereby hypotony can be avoided by increasing the flow rate through the device. In some embodiments, the device is a shunt that can have a first flow that can be modified to a second flow by modifying the shunt, such as by cutting the shunt. Additionally, one or more dissolvable portions can be present to provide an initial flow restriction and subsequent increase in flow over time.Type: GrantFiled: February 19, 2013Date of Patent: September 8, 2015Assignee: AqueSys, Inc.Inventors: Christopher Horvath, Laszlo O. Romoda, Brian Hamstrom, Ronald D. Bache, Guenther Grabner, Herbert A. Reitsamer
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Patent number: 9126010Abstract: A centering tool and a combined centering-indicator tool for finding the magnetic center and indicating the setting of an implantable adjustable valve. The centering and combined centering-indicator tools include a magnetic capsule movable within a cavity to a target located on the tool when the magnetic capsule is centered over magnet of an adjustable valve.Type: GrantFiled: March 14, 2013Date of Patent: September 8, 2015Assignee: Medtronic Xomed, Inc.Inventors: Deep Shah, Tony Daniel Cepeda, Lori Speckman, W. Jeff Bertrand, Lawrence Hampton
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Patent number: 9114230Abstract: An implantable valve system and method of using same, including a housing with a resilient membrane defining a reservoir in fluid communication with at least two ports, and at least a first set of opposing sealing features disposed on upper and lower surfaces within the housing. The membrane is capable of being depressed by a human finger to bring the sealing features together to substantially restrict fluid from passing through at least one of one of the ports, and is capable of being depressed additionally by a rolling motion of the finger to drive fluid through the other of the ports.Type: GrantFiled: September 28, 2012Date of Patent: August 25, 2015Assignee: DEPUY SYNTHES PRODUCTS, INC.Inventors: Stephen Wilson, Brian Soares
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Patent number: 9084677Abstract: The present invention is directed to methods and systems for adjusting an implant, such as a mitral valve ring, over the long term without having to enter a patient's body. The long term adjustment system can include a magnet, or other magnetic material, that is functionally connected to the adjustment mechanism of an adjustable implant. The long term adjustment system can be activated by placing an activating magnet near the area of the patient's body where the adjustable implant is located and positioning the activating magnet so that an attractive force is generated between the activating magnet and the magnet that is functionally connected to the adjustable implant. Due to the attractive force between the two magnets, rotation of the magnet outside the patient's body will adjust the size and/or shape of the implant.Type: GrantFiled: July 29, 2009Date of Patent: July 21, 2015Assignee: St. Jude Medical, Cardiology Division, Inc.Inventors: Richard G. Cartledge, John P. Cartledge
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Patent number: 9072865Abstract: An implantable drainage device for draining the cerebro-spinal fluid of a patient, the device including: a drainage valve including a valve member and a valve seat; a control unit suitable for modifying an operating parameter of said valve, at least as a function of a measurement (D) of the fluid flow rate through said valve; an actuator controlled by the control unit, suitable for modifying the operation of said valve as a function of said operating parameter as modified by the control unit; and a mass flowmeter suitable for evaluating said flow rate of fluid through said valve.Type: GrantFiled: March 13, 2009Date of Patent: July 7, 2015Assignee: SOPHYSAInventors: Philippe Negre, Christophe Moureaux, Christophe Boyer, Olivier Bonnal
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Patent number: 9050436Abstract: An anti-siphon drainage device having a housing forming an internal chamber, an inlet and outlet ports part of the internal chamber and fluidly connected by a primary flow path. A valve seat is associated with the primary flow path, a sloped section extends from the valve seat, and a valve element disposed in the sloped section and can seat in the valve seat to restrict a fluid flow into the primary flow path from the inlet port. A secondary flow path can have an opening near the inlet port and an orifice near the outlet port. A regulator has an aperture to selectively open and close the opening of the secondary flow path. When the valve element is seated in the valve seat and restricting the fluid flow into the primary flow path, the fluid flows into the secondary flow path.Type: GrantFiled: March 14, 2013Date of Patent: June 9, 2015Assignee: DePuy Synthes Products, LLCInventors: Stephen Wilson, Alyssa Trigger
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Publication number: 20150148731Abstract: Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter shunt portion which can be manually adjusted in vivo. Methods are provided for adjusting the flow rate of the devices in vivo.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Inventors: Edward I. MCNAMARA, Michael W. SUTHERLAND, Matthew J. FINCH, Stephen J. FORCUCCI, John MITZEL, David S. CELERMAJER, Hiroatsu SUGIMOTO
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Publication number: 20150148730Abstract: Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm's canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm's canal.Type: ApplicationFiled: June 26, 2014Publication date: May 28, 2015Inventors: Mary G. Lynch, Reay H. Brown
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Patent number: 9039652Abstract: A fluid management system for the treatment of ascites, pleural effusion or pericardial effusion is provided including an implantable device including a pump, control circuitry, battery and transceiver; a charging and communication system configured to periodically charge the battery and communicate with the implantable device to retrieve performance data; and monitoring and control software, suitable for use with conventional personal computers, for configuring and controlling operation of the implantable device and charging and communication system. The implantable device includes a number of features that provide automated movement of fluid to the bladder with reduced risk of clogging, with no patient involvement other than occasional recharging of the battery of the implantable device. The monitoring and control software is available only to the treating physician, such that the physician interacts with the implantable device via the charging and communication system.Type: GrantFiled: February 15, 2012Date of Patent: May 26, 2015Assignee: SEQUANA MEDICAL AGInventors: Thomas Werner Degen, Daniel Thomas Thommen, Noel L. Johnson
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Patent number: 9039649Abstract: Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.Type: GrantFiled: May 31, 2012Date of Patent: May 26, 2015Assignee: ValenTx, Inc.Inventors: Johann Neisz, Cole Chen, Sean Miller, Josiah Verkaik
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Patent number: 9033909Abstract: [Problem] Disclosed is a shunt valve for treatment of hydrocephalus such that the flow rate of cerebrospinal fluid drained from the brain ventricles can be freely regulated without drastically changing the intraventricular pressure when the pressure thereof becomes abnormal after a transplant.Type: GrantFiled: April 20, 2011Date of Patent: May 19, 2015Inventor: Yasuo Aihara
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Patent number: 9033943Abstract: A wound drainage device flow regulator for controlling fluid flow from a wound to a container. The regulator provides selective communication between a conduit and the container. The device includes a valve for communication between the conduit and the container in response to a level of vacuum in the conduit below a selected value. The valve has a diaphragm exposed to atmospheric pressure on one side and to the level of vacuum in the conduit on the other side. A force is applied to the diaphragm in opposition to atmospheric pressure. The difference between the force applied and the force generated by atmospheric pressure provides a control force required to be applied by the level of vacuum in the conduit to close the valve to interrupt communication between container and conduit. A lock mechanism locks the adjustable force mechanism at a desired adjustment corresponding to a desired level of vacuum.Type: GrantFiled: May 10, 2011Date of Patent: May 19, 2015Assignee: Research Medical Pty. Ltd.Inventor: Raymond Lawrence Stubber
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Patent number: 9022968Abstract: A device and system for controlling pressure via fluid exchange in the body is presented. The device and system may be used to control intraocular eye pressure. The system is comprised of four main components: a cannula, a sensor, a controller and a pump. The system works to engage in a fluid exchange which slowly increases/decreases intraocular pressure until a desired level is reached. Once the desired level is reached, the intraocular pressure is held steady and any external pressure perturbations are removed.Type: GrantFiled: January 8, 2014Date of Patent: May 5, 2015Assignee: University of South FloridaInventor: Christopher Lawrence Passaglia
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Patent number: 9017277Abstract: An implantable dialysis device with a related medical system for intracorporeal dialysis and ultrafiltration of blood, and methods of use are described. The medical system includes an extracorporeal module, a cutaneous module, and an implantable module. Features of the implantable module facilitate delivery and flow of blood and dialysate through the medical system. A filter pack within the implantable module performs dialysis and ultrafiltration of blood. System cleansing is also described.Type: GrantFiled: May 2, 2012Date of Patent: April 28, 2015Assignee: Medtronic, Inc.Inventors: SuPing Lyu, Thomas Edward Meyer, Mark Fredrick Daniels, Bryant J. Pudil
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Patent number: 9017275Abstract: A distal perfusion sheath (DPS) is provided for cases where blood perfusion is needed for downstream arteries (distal) to the insertion point of the DPS within the target artery. The ability to provide distal perfusion with the DPS allows the DPS to be positioned in the target artery for long periods without causing lack of blood flow (ischemia) to an extremity that the target artery supplies. In embodiments, the DPS can still be used for surgical arterial access while allowing blood flow downstream. In addition, embodiments of the DPS configured with longer perfusion shunts can allow a contra-lateral extremity downstream to a large DPS to have blood flow while the sheath is in place.Type: GrantFiled: July 13, 2012Date of Patent: April 28, 2015Assignee: Khoury Medical Devices, LLCInventor: Michael D. Khoury
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Patent number: 9011365Abstract: This invention is a device and method for adjustably and reversibly reducing nutrient absorption from food passing through a person's gastrointestinal tract using an Adjustable Gastrointestinal Bifurcation (AGB) and a flow-control member. The Adjustable Gastrointestinal Bifurcation (AGB) includes: a first food-flow route (comprising a first branch of the AGB) through the person's gastrointestinal tract wherein there is normal absorption of nutrients from food; and a second food-flow route (comprising a second branch of the AGB) through the person's gastrointestinal tract wherein there is reduced absorption of nutrients from food. The flow-control member adjusts the types and/or amounts of food which are diverted through the second food-flow route versus the first food-flow route.Type: GrantFiled: March 12, 2013Date of Patent: April 21, 2015Assignee: Medibotics LLCInventor: Robert A. Connor
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Patent number: 9011364Abstract: Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.Type: GrantFiled: March 17, 2011Date of Patent: April 21, 2015Assignee: Silk Road Medical, Inc.Inventors: Enrique Criado, Tony M. Chou, Michi E. Garrison, Gregory M. Hyde, Alan Schaer, Richard Renati
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Patent number: 8998838Abstract: A drainage device for implantation in an eye of a patient to treat an ocular condition, that includes an implant body portion comprising of a valve portion. The valve portion may comprise a flexible membrane disposed and arranged in a manner to affect flow of aqueous humor through the implant body portion. The device may also include a reed valve disposed downstream of the flexible membrane. The reed valve may be configured to prevent backflow of aqueous humor toward the membrane and configured to stabilize flow by affecting pressure at the flexible membrane. In one aspect, the reed valve is configured to create backpressure at the membrane that affects the rate of flow at the flexible membrane.Type: GrantFiled: March 29, 2012Date of Patent: April 7, 2015Assignee: Alcon Research, Ltd.Inventor: Satish Yalamanchili
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Publication number: 20150094644Abstract: A system for the treatment of Alzheimer's disease is provided by moving cerebrospinal fluid containing particles know to contribute to onset of Alzheimer's disease from a source of cerebrospinal fluid to the stomach or bladder, where the particles are safely digested by gastric acid or excreted, the system including an implantable pump, an inlet catheter, an outlet catheter, and a one-way valve. The system further includes at least one filter to filter harmful particles from the cerebrospinal fluid and return the filtered cerebrospinal fluid back to the source of cerebrospinal fluid, where the harmful particles blocked by the filter may be rinsed off the filter and transported to the stomach or bladder.Type: ApplicationFiled: September 30, 2014Publication date: April 2, 2015Applicant: MD START SAInventors: Tim Lenihan, Bruce Meadows
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Publication number: 20150094643Abstract: An adjustable height tool for locating a magnetically readable and settable valve implanted in a living being. The locator can include a wall having a first perimeter. A platform can be disposed within the first perimeter. A valve cut-out can disposed within the platform and can approximate at least a portion of the shape of the valve. A movable foot can be disposed below the platform by which a displacement element moves the foot at least one of toward or away from the platform. This movement increases or decreases the distance between the platform and the skin/valve. Two or more recesses can be disposed in the foot and the recesses can be aligned with the valve cut-out. The displacement element can maintain the alignment of the recesses and the cut-out while moving the foot.Type: ApplicationFiled: September 30, 2013Publication date: April 2, 2015Applicant: DEPUY SYNTHES PRODUCTS, LLCInventors: Brian Soares, Alyssa Trigger, Michael DeFusco, Stephen F. Wilson
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Publication number: 20150088049Abstract: An implantable device for the treatment of hydrocephalus syndrome, characterised by a mechanical passive valve device designed to move the cerebrospinal fluid in the cranial site of the patient, comprising a cylindrical body, a piston, and a special spring exhibiting a non-linear characteristic and suitable for applying a force on the piston such that, when the pressure of the cerebrospinal fluid acting on the two opposite faces of the piston exceeds a certain value, a rapid displacement of the piston in the cylindrical body takes place due to the non-linear characteristic of the spring, with consequent aspiration, by the same piston, of a greater quantity of cerebrospinal fluid contained in the ventricle and, when the pressure of the cerebrospinal fluid falls below a certain value, the piston reacts and moves rapidly in a direction opposite to the first, so as to feed into the ventricle the cerebrospinal liquid previously aspirated.Type: ApplicationFiled: September 16, 2014Publication date: March 26, 2015Inventor: Carmelo Anile
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Patent number: 8986240Abstract: An IOP control valve is disclosed. The IOP control valve comprises a corrugated membrane and a housing including a fluid inlet and a fluid outlet. The corrugated membrane is anchored within the housing to form a reference chamber on a first side of the corrugated membrane and a fluid flow channel on a second opposing side of the membrane. The reference chamber has a reference chamber pressure representative of atmospheric pressure. The fluid flow channel can selectively increase and decrease in size to permit fluid to flow from the fluid inlet to the fluid outlet. The corrugated membrane is configured to affect flow through the fluid flow channel from the fluid inlet to the fluid outlet by deflecting in response to pressure differentials of the reference chamber pressure and the fluid flow channel pressure acting on the opposing sides of the corrugated membrane.Type: GrantFiled: February 14, 2012Date of Patent: March 24, 2015Assignee: Alcon Research, Ltd.Inventors: Cesario P Dos Santos, Robert J Sanchez, Jr., Leslie A Field
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Publication number: 20150073329Abstract: Devices, systems, and methods for autoretroperfusion.Type: ApplicationFiled: November 18, 2014Publication date: March 12, 2015Inventor: Ghassan S. Kassab
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Patent number: 8974511Abstract: The present invention generally relates to methods for treating closed angle glaucoma. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular shunt, using the device to re-open an at least partially closed anterior chamber angle of an eye, and deploying the shunt from the device.Type: GrantFiled: November 15, 2010Date of Patent: March 10, 2015Assignee: AqueSys, Inc.Inventors: Christopher Horvath, Laszlo O. Romoda
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Patent number: 8968927Abstract: A biodegradable battery is provided. The battery includes an anode comprising a material including an inner surface and an outer surface, wherein electrochemical oxidation of the anode material results in the formation of a reaction product that is substantially non-toxic and a cathode comprising a material including an inner surface and an outer surface, the inner surface of the cathode being in direct physical contact with the inner surface of the anode, wherein electrochemical reduction of the cathode material results in the formation of a reaction product that is substantially non-toxic, and wherein the cathode material presents a larger standard reduction potential than the anode material.Type: GrantFiled: November 12, 2013Date of Patent: March 3, 2015Assignee: Covidien LPInventors: Gerald Hodgkinson, William O. Powers, Ahmad Robert Hadba
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Patent number: 8968926Abstract: A biodegradable battery is provided. The battery includes an anode comprising a material including an inner surface and an outer surface, wherein electrochemical oxidation of the anode material results in the formation of a reaction product that is substantially non-toxic and a cathode comprising a material including an inner surface and an outer surface, the inner surface of the cathode being in direct physical contact with the inner surface of the anode, wherein electrochemical reduction of the cathode material results in the formation of a reaction product that is substantially non-toxic, and wherein the cathode material presents a larger standard reduction potential than the anode material.Type: GrantFiled: July 15, 2011Date of Patent: March 3, 2015Assignee: Covidien LPInventors: Gerald N. Hodgkinson, William Powers, Ahmad Robert Hadba
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Patent number: 8968233Abstract: An arteriovenous shunt assembly including a shunt having a hollow bore between open first and second ends thereof and a valve slidably disposed through the hollow bore. The valve includes means for retaining the valve in a closed position or in any of various selected open positions that provide corresponding different rates of blood flow through the shunt assembly. In some embodiments, the AV shunt assembly is self-expandable from a collapsed tow-profile configuration employed during transluminal delivery. The valve position in the hollow bore may be adjusted in vivo by inflating a catheter balloon in a blood vessel to bear against an end of the valve. Methods for using the shunt assembly are also disclosed.Type: GrantFiled: February 3, 2012Date of Patent: March 3, 2015Assignee: Medtronic Vascular, Inc.Inventors: Niall Duffy, Kevin O'Sullivan
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Publication number: 20150057593Abstract: An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein.Type: ApplicationFiled: August 24, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventors: Andrew David Johnson, Nicholas Max Gunn
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Publication number: 20150057594Abstract: A microfluidic valve for implantation in an eye of a patient is disclosed. The valve may include a chamber formed between a substrate and a flexible membrane. The valve may also include a boss disposed in the chamber and having a top edge in selective contact with the flexible membrane. The top edge includes a relief portion and a non-relief portion, with the relief portion being structurally arranged so that a pressure required to separate the membrane from the relief portion is less than a pressure required to separate the membrane from the non-relief portion. The valve also may include an inlet extending through the boss and the substrate through which fluid enters the chamber and an outlet configured to allow fluid to exit the chamber. Methods for priming a microfluidic valve are also disclosed.Type: ApplicationFiled: August 24, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventors: Nicholas Max Gunn, Andrew David Johnson
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Publication number: 20150057595Abstract: Described herein is an IOP control device for implantation in an eye of a patient, comprising a drainage tube, a pressure-driven flow system, and a flow rate measurement system. The drainage tube includes a drainage lumen in fluid communication with an anterior chamber of the eye. The flow system is in fluid communication with the drainage lumen, and is configured to control the flow of fluid through the drainage tube. The flow rate measurement system is disposed distal to the flow system, and comprises a flow tube including a known hydraulic resistance to flow, a proximal pressure sensor disposed at the proximal end of the flow tube, and a distal pressure sensor disposed at the distal end of the flow tube. The flow tube includes a proximal end, a distal end, and a lumen extending therebetween that is configured to be in fluid communication with the drainage lumen.Type: ApplicationFiled: August 24, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventors: Nicholas Max Gunn, Andrew David Johnson
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Publication number: 20150057597Abstract: Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway.Type: ApplicationFiled: August 26, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventors: Andrew David Johnson, Cesario Pereira Dos Santos, Casey Jean Lind
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Publication number: 20150057596Abstract: Described herein is an IOP control system for implantation in an eye of a patient, comprising a drainage device and a control device. The drainage system includes a housing including an inlet port and an outlet port, a fluid flow passageway extending from the inlet port to the outlet port to allow the flow of fluid therethrough, and at least one valve disposed within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing sides. The control device comprises an actuator including an activated mode and a deactivated mode, and the actuator in the activated mode is configured to selectively adjust flow through the drainage device in response to changes in intraocular pressure.Type: ApplicationFiled: August 26, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventors: Casey Jean Lind, Cesario Pereira Dos Santos
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Publication number: 20150057592Abstract: A MEMS check valve chip is described. The chip comprises a first side and an opposing second side, an outlet port extending from the first side to the second side, and a flexible outlet membrane anchored to the first side to overlie the outlet port. The flexible outlet membrane includes an outlet aperture and a sealing portion, and the sealing portion is movable between a closed position inhibiting fluid flow through the outlet aperture and an open position wherein the sealing portion displaces into the outlet port to permit fluid flow through the outlet aperture.Type: ApplicationFiled: August 24, 2013Publication date: February 26, 2015Applicant: ALCON RESEARCH, LTD.Inventor: Nicholas Max Gunn
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Patent number: 8961448Abstract: An implantable drainage device is provided. The device is adapted to move body fluid from one part of the body of a patient to another part of the body.Type: GrantFiled: January 28, 2009Date of Patent: February 24, 2015Inventor: Peter Forsell
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Patent number: 8961447Abstract: An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas extending over more than 50% of a surface defining the curved volume, the strut areas surrounding the open areas, the body having a diameter of between 0.005 inches and 0.04 inches. The invention also provides a method of treating glaucoma including the steps of supporting tissue forming Schlemm's canal in an eye with an implant extending at least partially in the canal along an axial length within the canal; and contacting with the implant less than 50% of the tissue forming the canal along the axial length.Type: GrantFiled: February 25, 2013Date of Patent: February 24, 2015Assignee: Ivantis, Inc.Inventors: Andrew T. Schieber, Charles L. Euteneuer
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Publication number: 20150051533Abstract: A method for controlling appetite by means of a satiation device is disclosed. The device, which includes a flexible webbing defining proximal and distal openings and a biasing structure, is attached to the patient's stomach with the proximal opening positioned adjacent and below the patient's gastro-esophageal junction. The biasing structure imparts pressure against the wall of the patient's stomach adjacent the gastro-esophageal junction.Type: ApplicationFiled: October 23, 2014Publication date: February 19, 2015Inventors: Richard S. STACK, William L. Athas, Richard A. Glenn, Daniel Balbierz, John Lunsford, Michael S. Williams
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Patent number: 8956320Abstract: A capillary fluid flow valve may include a chamber having a first boundary surface and a second boundary surface defined by a housing. The first and second boundary surfaces may be spaced apart by a gap sized to invoke capillary action between the surfaces. The first surface may be angled relative to the second surface. The chamber may have an inlet port, an outlet port, and an air vent port. The gap at the air vent port may be smaller than the gap at the outlet port and the gap at the outlet port may be smaller than the gap at the inlet port.Type: GrantFiled: August 28, 2012Date of Patent: February 17, 2015Assignee: Alcon Research, Ltd.Inventors: Mikhail A. Ovchinnikov, Satish Yalamanchili
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Patent number: 8956318Abstract: Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.Type: GrantFiled: May 31, 2012Date of Patent: February 17, 2015Assignee: ValenTx, Inc.Inventors: Sean Miller, Cole Chen, Juan Madrigal, Johann Neisz, Josiah Verkaik
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Publication number: 20150045716Abstract: An intraocular pressure compensating and regulating valve installed inside the eye's cornea, comprising: a valve body having a valve seat at an end; a mobile element connected to the valve seat under normal intraocular pressure conditions inside the eye, the mobile element is configured such that it can be separated from the valve seat when the intraocular pressure exceeds the intraocular pressure limit; and an element to keep the mobile element in contact with the valve seat.Type: ApplicationFiled: October 17, 2013Publication date: February 12, 2015Inventor: Manuel Humberto Gallardo Inzunza
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Publication number: 20150045717Abstract: A system for measuring quantitative CSF flow in shunt tubing implanted under the skin. The system includes an array of thermo-sensors clustered in three sections, cooling device, placed on the skin surface and an associated data acquisition and analysis device. Two sensor sections are placed over the shunt on the skin and measure real time temperature responses related to CSF movement. One array placed adjacent the cooling device collects data on thermal properties of skin including skin thermal conductivity, specific heat, diffusivity, perfusion, and thermal inertia. The method involves assessing thermal properties of skin and measuring CSF flow in shunt tubing. The method is useful for shunt patency assessment, CSF valve adjustment procedures and CSF flow measurements related to CSF over drainage. Alternatively, only one section of sensors need be used when determining relative CSF flow, without the need to determine thermal skin properties and by applying the cooling device continuously.Type: ApplicationFiled: October 14, 2014Publication date: February 12, 2015Inventors: Marek Swoboda, Matias Gabriel Hochman, Mark Evan Mattiucci, Frederick J. Fritz
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Patent number: 8951221Abstract: The invention relates to a method and device for the treatment of glaucoma, though insertion of an implant into the lumen of the Schlemm's canal to realize proper drainage of the aqueous humor, which implant is brought into its position in the Schlemm's canal by means of a catheter having a distal and a proximate portion and provided with a number of pores through which a gaseous or fluid medium which comes from a pressure source can emerge during insertion of the catheter carrying the implant into the Schlemm's canal, and while the catheter is being inserted into the Schlemm's canal the gaseous or fluid medium is released under pressure thereby expanding the Schlemm's canal and the implant and upon releasing the implant at its determined location, the catheter can be withdrawn from the Schlemm's canal.Type: GrantFiled: August 20, 2009Date of Patent: February 10, 2015Assignee: Grieshaber Ophthalmic Research FoundationInventors: Robert Christopher Stegmann, Matthias Christian Grieshaber, Hans Rudolf Grieshaber
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Patent number: 8951223Abstract: Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter shunt portion which can be manually adjusted in vivo. Methods are provided for adjusting the flow rate of the devices in vivo.Type: GrantFiled: December 24, 2012Date of Patent: February 10, 2015Assignee: DC Devices, Inc.Inventors: Edward McNamara, Michael W. Sutherland, Matthew J. Finch, Stephen J. Forcucci