Abstract: Catheter apparatuses having expandable mesh structures and associated systems and methods for intravascular renal neuromodulation are disclosed herein. A catheter treatment device includes an expandable mesh structure configured to position an energy delivery element in contact with a renal artery via an intravascular path. The mesh structure can assume an expanded configuration for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function. A collapsed configuration may facilitate insertion and/or removal of the catheter or repositioning of the energy delivery element within the renal artery.

Abstract: The illumination system is a cannula comprising a transparent or semi-transparent material capable of carrying light from the proximal end of the cannula to the distal end of the cannula, thereby illuminating a surgical field. The surgical field is thus illuminated through components that do not occupy space that may otherwise by used for optics and or surgical tools. The illumination source may be optically coupled with the cannula at any appropriate location. The cannula comprises a sterilizable polymer which functions as a waveguide. A waveguide is a material medium that confines and guides light. When in use, the light source connected to the hub provides light which may be guided to the distal end of the cannula or any other suitable location. Thus, the sheath provides structure-guided illumination resulting in the illumination of the surgical site.

Abstract: An interstitial laser energy treatment apparatus having co-acting movable probe holders which facilitate positioning of a laser probe and thermal probe in different positions relative to a tissue mass such as the tumor to be treated and relative to each other to facilitate treating tissue masses based on the exact position, size and shape of the tissue mass.

Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues, particularly as utilized for the ablation of cardiac tissue in the treatment of atrial fibrillation. The device is a closed or semi-closed system in which the liquid cryogen is nitrogen contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state, specifically supercritical nitrogen, and may be utilized in any rapid cooling systems. As designed, the device also integrates endocardial catheters and epicardial probes.

Abstract: A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheter's rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheath's helical grooves or slots against the cutting head's protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.

Abstract: A method and apparatus for adipose tissue treatment whereby two types of electromagnetic radiation are applied to the volume of tissue to be treated, One type of the electromagnetic radiations being RF and the second type of electromagnetic radiation being visible or infrared radiation.

Abstract: A laser surgical method is disclosed including: providing a laser surgical device including a handpiece including: an optical delivery component that transmits laser energy from a source to a treatment volume; and an accelerometer configured to provide information indicative of the position of the handpiece. The method includes using the handpiece to transmit laser energy from the source to a plurality of positions within the treatment volume; using the accelerometer, providing information indicative of the position of the handpiece; determining information indicative of an amount of energy delivered at each of the plurality of positions within the treatment volume based on the information indicative of the position of the handpiece, and displaying a graphical representation indicative of the amount of energy delivered at each of the plurality of positions within the treatment volume.

Abstract: An ultrasonic surgical instrument is presented including an ultrasonic transmission member having a proximal end and a distal end, and a handle member located at the proximal end of the transmission member. The ultrasonic surgical instrument also includes an end effector assembly located at the distal end of the transmission member. The end effector assembly includes a sensing mechanism for sensing load variations on tissue based on mechanical vibrations detected on one or more portions of the surgical instrument, the mechanical vibrations sensed by a laser interferometer.

Abstract: Irradiating an orbitofrontal cortex of a patient having postpartum depression with red/near infrared light in order to increase metabolism, bcl-2 and BDNF in the patient's orbitofrontal cortex.

Abstract: A light therapy device for rhinitis treatment. The light therapy device includes a hollow tube body with a longitudinal axis, being dimensioned and configured to permit insertion into a nostril of a treatment subject. A light emitting diode package disposed within the hollow tube body includes a first LED chip as a red light source and a second LED chip as an infrared light source. The first LED chip and the second LED chip are at different plane substantially orthogonal to the longitudinal axis.

Abstract: A laser-based method and system for selectively processing target tissue material in a patient and optical catheter assembly for use therein are provided. The system includes a laser subsystem for generating an output laser beam. The system further includes a catheter assembly including at least one optical fiber having a proximal end coupled to the laser subsystem for guiding the output laser beam along a propagation path. The beam has optical and temporal properties and a predetermined selected wavelength. The catheter assembly is sized to extend through an opening in a first part of the patient and to a tissue material processing site within the patient.

Abstract: A connectorized ultrasound probe includes a distal section that is configured for insertion into a patient's body and a proximal section configured to interface the distal section with an ultrasound system. The distal section is easily attachable and detachable from the proximal section using at least one set of connectors. When connected, a user-operated actuator located on the proximal section controls the bending of the distal section, and the ultrasound system sends driving signals to and receives return signals from the ultrasound transducer via the proximal section. This arrangement is particularly advantageous for long term monitoring, because the disconnectability of the proximal section makes it possible to leave the distal section in place in the patient for longer periods of time without undue discomfort.

Abstract: Exemplary embodiments of apparatus and method for effecting at least one anatomical structure of a body can be provided. For example, at least one first arrangement can be provided which is structured to be at least partially inserted into the body and including an opening. In addition, at least one second arrangement can be provided which configured to increase and/or decrease a size of the opening by a motion thereof in a first direction. Further, at least one third arrangement can be provided which can be coupled to the second arrangement(s), and configured to move at least in a second direction which is at least approximately parallel to the second direction.

Abstract: A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.

Abstract: A surgical probe apparatus is disclosed including a handpiece which includes an optical system configured to deliver therapeutic light to provide treatment of an area of tissue; and at least one suction port configured to remove a byproduct of the treatment from the area of tissue in response to an applied vacuum.

Abstract: A device is provided for illuminating a tissue surface to be treated. The device includes a catheter, a light emitting diode in the distal tip of the catheter, and a distal cap disposed over the distal end of the catheter. The device includes a handle connected to the proximal end of the catheter. An external source of energy is provided for supplying energy to the light emitting diode and for controlling the light emitting diode.

Abstract: Methods and devices for internal tissue removal by means of laser energy are provided. In a preferred embodiment, a method for internal tissue removal in which tissue is removed in the form of fluid (liquid, vapor), solid debris and/or a combination of these is provided. Other embodiments disclose a method and a photodynamic method for the treatment of urological disorders such as benign prostatic hyperplasia. In another embodiment, a treatment system comprises infusion and vacuum hoses, a laser energy source with a wavelength or wavelength combinations for higher tissue ablation rates as well as reduced bleeding. As an advantageous feature, this invention can be applied to any kind of soft tissue which needs to be removed from the body. In addition, as it is not limited to hollow organs, it can be performed with or without using an endoscope. The method of internal tissue removal disclosed is safe, efficient, with enhanced outcomes and can be performed with less patient and surgeon stress.

Abstract: A light-based method of endovascular treatment, in particular, of pathologically altered blood vessels. Provided are a Method of Endovascular Light Treatment and a corresponding Endovascular Light Application Device.

Abstract: A laser tip has at least a portion of its surface as a more easily cleaned surface. In some embodiments, the more easily cleaned surface may be formed integrally with the laser tip. In some embodiments, the more easily cleaned surface may be a coating or sheath that covers the exposed exterior surface and can be removed after surgery for cleaning or disposal. The more easily cleaned surface may include a lubricious coating which may prevent or minimize the adherence of charred matter on the tip.

Abstract: Described are a handpiece, a coupling, and a device with a laser source and handpiece for emitting a laser beam for dental treatment. In order to avoid damage to the healthy tooth tissue, an improved determination of the tooth temperature by measurement of at least part of the heat radiation emitted from the treatment area using a temperature sensor, preferably an infra-red sensor, is carried out. Upon reaching or exceeding a temperature threshold, the emission of the laser beam to the treatment area is interrupted or the power output of the laser source reduced or the user made aware of the violation of the threshold value using an acoustic or visual signal. The temperature sensor can be located, e.g., on the handpiece or on the coupling, such as on the coupling tube.

Abstract: Disclosed are apparatus, method, devices and instruments, including an apparatus that includes a flexible waveguide coupled to a supporting structure, and further coupled to a treatment tip. The apparatus also includes a beam controller to control application of a radiation beam emitted from the flexible waveguide to distribute the beam over an area different than an area covered by direct application of the beam to a single location on a target tissue. Further disclosed is an apparatus that includes a waveguide, coupleable to a laser source, and a thermal protection instrument. The thermal protection instrument includes a tissue contacting member to contact a part of an area of a tissue irradiated by laser radiation, and a beam blocking element to absorb at least some of radiation not absorbed by the area of the tissue, the beam blocking element being thermally isolated from the area of the tissue.

Abstract: A cardiac tissue ablation system includes an elongate catheter configured to deliver a distal end thereof to a patient's heart and an expandable member formed at the distal portion of the catheter. The expandable member has an elastic portion configured to conform to the shape of a target tissue region upon expansion. The expandable member has a plurality of inflation settings that correspond to different levels of inflation of the expandable member. The system also includes a controller for selecting an inflation setting for the expandable member and an energy emitter movably disposed within a lumen of the catheter. The energy emitter is configured to deliver radiant ablative energy to the target tissue region.

Abstract: A system is provided for identifying the sufficiency of lesions formed during a tissue ablation procedure. The system captures live and still images from the surgical site and provides composite imaging to the operator. Through the use of the system, the aiming light used to direct ablative energy is captured on the still images and used to indicate locations in a surgical site where energy has been directed. Through the use of processing modules, the system can analyze the lesions and determine the sufficiency thereof.

Abstract: A method for treating a cardiac condition with visual inspection of a tissue treatment site includes the step of delivering an expanding member formed on a distal end of a catheter to a position adjacent a tissue treatment area within a patient's heart. The expandable member has an elastic portion configured to conform to the tissue treatment area. The method further includes the steps of expanding the expandable member thereby allowing the elastic portion of the expandable member to conform to the tissue treatment area and positioning an energy emitter at a first location within an inner lumen of the catheter. A visible aiming beam is projected during positioning of the energy emitter and ablative energy is delivered from the energy emitter to the tissue treatment area thereby resulting in a first spot lesion.

Abstract: A method for treatment of atrial fibrillation includes utilizing mathematical analysis, e.g., logistic regression, on a collection of variables selected from the group including effective refractory period, wavelength, tissue area, tissue weight, maximum tissue width, minimum tissue width, and average tissue width to design a set of lesions that would make an atria fibrillation-proof. Preferably, the most preferred variables are tissue area, effective refractory period, and conduction velocity. This is preferably an electrophysiologically-customized procedure that is preferably minimally invasive, which could include transvenous or port access, either off or on bypass to create the set of lesions that render an atria fibrillation-proof based on the mathematical analysis of selected variables. Long linear lesions are created from a variety of energy sources as well as surgical techniques. Preferably, there are fixation and marking mechanisms utilized.

Abstract: The illumination system described below comprises an arthroscope, endoscope or other suitable surgical tool and an attachable cannula comprising a transparent or semi-transparent material capable of carrying light from the proximal end of the cannula to the distal end of the cannula, thereby illuminating the surgical field. The surgical field is thus illuminated through components that do not occupy space that may otherwise by used for the optics of the arthroscope. The arthroscopic illumination system further comprises one or more illumination sources disposed at the proximal end of the cannula. The illumination source may be optically coupled with the cannula at the hub or other appropriate location. The cannula comprises a sterilizable polymer which functions as a waveguide. A waveguide is a material medium that confines and guides light. When in use, the light source connected to the hub provides light which may be guided to the distal end of the cannula or any other suitable location.

Abstract: A method and device for thermal fat destruction and collagen contraction The method comprises delivering optical energy into the adipose tissue under the skin to create thermal damage of fat, with an alteration of the overlying soft tissue contour and heating of dermis to sub-necrotic temperature to cause skin tightening. The device comprises a treatment cannula and tip connected to the cannula and optimizing light distribution for effective energy use.

Abstract: Devices and methods for clamping tissue and/or moving two tissue structures together by moving two plates or arm together. The pressure or force applied to the tissue may be used to bring the tissue together, to seal an opening or to cut through and remove a portion of the tissue. In one procedure disclosed, a clip applier may be used to apply one or more clips to the left atrial appendage of the heart to prevent clots from the left atrial appendage from embolizing and causing harm to the patient, such as a stroke.

Abstract: Low level laser energy may be delivered transmucosally to the vagina or other pelvic tissue. Such a device and its method of use may lead to healing of tissue, reduction of inflammation and pain, reduction in bladder problems such as urgency, frequency, and urinary incontinence, reshaping of tissue, and creation of a fertile environment for the potential implantation of stem cells. A probe may be moved in and out of the vagina in order to deliver the energy to the selected tissues. The probe may have a bulbous distal end that provides laser energy in a uniform 360 degree pattern or as close to 360 degrees of illumination as is structurally possible. Alternate embodiments may emit laser energy anywhere within the range from 0 degrees to 360 degrees. The scope of the present invention further includes the possibility of substituting alternate energy sources in place of laser energy.

Abstract: Provided is surgical instrument which can provide a field of view over surgical site by sucking blood from bleeding site during surgery on body tissue of patient and monitoring dark and deep surgical site, which operator cannot see with his or her naked eye, with small camera. The surgical instrument has substantially the same shape as a pair of scissors and includes first body, second body having shape symmetrical to that of the first body, hinge to which the first and second bodies cross and are rotatably coupled, and photographing unit provided in the hinge to photograph a surgical site between front ends of the first and second bodies. The photographing unit may include camera mounted in the hinge such that lens of the camera can be exposed through the center of the front surface of the hinge and configured to transmit photographed image data to monitor.

Abstract: A tissue ablation device employs one or more energy emitters (21) and one or more photoacoustic sensors (22) in a cooperative arrangement for applying a tissue ablation therapy to a tissue (60). In operation, the energy emitters (21) emit a tissue ablation beam (TA) into a target portion of the tissue (60) to form a lesion (61) therein, and alternatively or concurrently emit a photoexcitation beam (PE) into the target portion of the tissue (60) to excite a photoacoustic response from the tissue (60). The photoacoustic sensor(s) (22) sense the photoacoustic response of the tissue (60).

Abstract: A laser induced liquid jet generating device comprising: a main body 6 adapted to be filled with a specified laser beam absorbing liquid and configured such that it can contain a laser irradiating part 4 of an optical fiber from which laser beams are emitted to generate jet streams J of said liquid W by irradiating said liquid W with laser beams, with said jet streams J ejected from said main body 6 to the outside; said main body 6 comprising: a catheter mounting unit mounted integrally or in a removable manner on a catheter member 13 into which said jet stream J is introduced; a jet generating tube unit 10 in which said laser irradiation part 4 is adapted to be positioned; and a heat transfer inhibition means 11 for inhibiting thermal effect due to laser beams irradiated by said laser irradiating part 4 from being transferred outside through said jet generating tube unit 10.

Abstract: The present invention provides a surgical instrument allowing a surgeon to identify a location of a blood vessel in tissue by hearing a blood flow sound in a thoracoscopic or laparoscopic surgery. One end of a tubular member is introduced into a body of a patient and is allowed to contact the tissue in such a manner as to block a first opening of the tubular member. Accordingly, a sound within the tissue and a sound of the tissue being in contact with the one end of the tubular member are collected by a cone member which is disposed to the first opening of the tubular member and includes a microphone disposed to the tip portion thereof. Accordingly, the surgeon can use the sense of hearing to hear the collected sound instead of the sense of touch in the thoracoscopic or laparoscopic surgery. That is, in a case where the location of the blood vessel within the tissue is to be identified, the one end of the tubular member is allowed to contact the tissue.

Abstract: The light irradiation device 1 is provided with a laser light source 10 for generating laser light, a light source for detection light 20 for generating detection light of a predetermined wavelength, an optical fiber 30 having a FBG 32 for inputting laser light on one end face 30a and emitting the light from the other end face 30b to radiate it to an object 3, inputting detection light on the one end face 30a and also reflecting the light of a predetermined wavelength adjacent to the other end face 30b, a light detector 50 for detecting an intensity of detection light reflected by the FBG 32 and emitted from the one end face 30a, and a signal processing unit 60 for detecting an irradiation state of the laser light to the object 3 based on an intensity of the thus detected detection light. The laser light generated from the laser light source 10 is light other than that of a wavelength reflected by the FBG 32.

Abstract: The invention relates to a system for medicinal treatment, in particular for treating benign prostatic hyperplasia BPH, for use in the event of tumor resection or for use in thoracic surgery. The system comprises a diode laser device for producing a laser beam and to an application system based on optical wave guides that can be endoscopically introduced into a patient. Said system is designed in such a manner that the laser beam, produced by the diode laser device is guided through the application system and is emitted by said application system so that biological tissue can be treated in a selective manner with the emerging laser beam.

Abstract: Methods and devices described herein facilitate improved treatment of body organs.

Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: An intracerebral probe (11) comprising a first part (20) with laser or cryogenic treatment means and further comprising a hollow second part (22) surrounding the first, the first part sliding inside the second part along its longitudinal axis (A); and a plurality of detectors (16) distributed along a portion of the second part (22) in such a manner as to be capable of identifying a brain dysfunction zone along the longitudinal axis (A) of the second part. Advantageously, the probe presents a lateral treatment window enabling the action of the treatment means to be directed. The invention also provides a kit and a treatment system including such a probe, and the use thereof of treating cell dysfunctions that give rise to neurological or psychiatric symptoms.

Abstract: A system for ablating tissue comprises an ergonomically shaped handpiece having a proximal end and a distal end. An energy source is near the distal end of the handpiece and is adapted to deliver energy to the tissue and create a zone of ablation that blocks abnormal electrical activity in the tissue. The system also includes a barrier near a front face of the energy source. The barrier is adapted to prevent direct contact between blood and the energy source so that the blood does not coagulate on the front face.

Abstract: Coupler assemblies and methods are disclosed as the coupler assemblies may be used with a catheter. An exemplary coupler assembly includes a spherical linkage coupler for a catheter. The coupler comprises a first cylinder portion for connecting to a structure, and a second cylinder portion for connecting to a distal end of a body of the catheter. The coupler also comprises a spherical linkage including at least two link arms. Each of the two link arms are connected on one end to the first cylinder portion and on the other end to the second cylinder portion. The two link arms connect a portion of the structure to the distal end of the catheter and enable the structure to move relative to the distal end of the catheter in response to an external force exerted on the structure.

Abstract: Various embodiments of an offset catheter are provided. In some embodiments, an offset catheter includes a guidewire tube and a catheter coupled with an elastic and/or compressible rib. The compressible rib provides an offset or separation between the catheter and the guidewire tube in its resting state. The rib has an initial resting state, but may be forced into a compressed state. When released from the compressed state, the rib returns to its resting state. An offset catheter may be compressed and slid through a sheath. When the offset catheter emerges from the sheath, the distal tip will return to its resting state providing an operation offset.

Abstract: Various embodiments of an eccentric balloon catheter are disclosed. In some embodiments, an eccentric balloon catheter includes an eccentrically positioned guidewire tube, with an interior lumen, that extends at least a portion of the length of the catheter body. Optical fibers may extend the length of the catheter body and may also be eccentrically positioned within the catheter body. An inflatable balloon may be positioned within a window within the catheter body near the distal end of the catheter. When inflated, the balloon and catheter may slide relative to one another. When used within a vessel, an inflated balloon may press against a vessel wall and bias the catheter toward an opposite vessel wall.

Abstract: The invention relates to a gastric restraining device for treating excessive weight or obesity in mammals. The gastric restraining device includes an elastomeric sheet configured to be placed around a stomach of a mammal, an ablation device attached to the elastomeric sheet, the ablation device configured to emit energy toward an outer surface of the stomach when the elastomeric sheet is placed around the stomach, and an energy device coupled to the ablation device to generate the energy and to transfer the energy to the ablation device.

Abstract: A medical device includes a sheath having a lumen and an elongate member disposed within the lumen of the sheath. The elongate member is moveable relative to the sheath and includes a retrieval assembly. The retrieval assembly has a collapsed position within the lumen of the sheath and an expanded position when extended beyond a distal end of the sheath. The elongate member defines a lumen configured to receive a laser.

Abstract: In some embodiments, without limitation, the invention comprises a catheter having an elongated housing with a channel disposed therein. A laser delivery member is movable and at least partially disposed within the channel. A ramp is disposed within the housing at an angle to its central axis and proximate to its distal end. The ramp is adapted to move the distal end of the laser delivery member outwardly from the central axis of the housing. A guidewire biases the distal end of the laser delivery member generally inwardly toward the central axis of the housing. In some embodiments, without limitation, the offset of the central axis of the tip of the laser delivery member from the central axis of the housing is determined by adjusting the extent to which the laser delivery member travels on the ramp, and disposition of the laser delivery member on the guidewire maintains the offset tip substantially parallel to the central axis of the housing.

Abstract: A system for inducing desirable temperature effects on body tissue, the body tissue being disposed about a lumen. The system includes an elongate catheter having a proximal end and a distal end with an axis therebetween with an energy delivery portion for transmission of energy. A tissue analyzer configured to characterize the body tissue in the lumen proximate the energy delivery portion and an energy source coupled to the energy delivery portion transmitting tissue treatment energy, wherein the energy is non-RF energy. A processor coupled to the tissue analyzer and energy source, the processor configured to determine an appropriate treatment energy for the characterized body tissue so as to mildly heat the body tissue with the energy delivery portion without ablating.

Abstract: An ablation system for treating atrial fibrillation in a patient comprises an inner shaft having proximal and distal ends as well as a lumen therebetween. A distal tip assembly is adjacent the inner shaft distal end, and the distal tip assembly comprises an energy source and a sensor. The energy source is adapted to deliver energy to a target tissue so as to create a zone of ablation in the target tissue. This blocks abnormal electrical activity and thus reduces or eliminates atrial fibrillation in the patient. The system also has an outer shaft with proximal and distal ends, and a lumen therebetween. The inner shaft is slidably disposed in the outer shaft lumen, and the inner shaft is rotatable, bendable and linearly slidable relative to the outer shaft. The outer shaft is rotatable, bendable and linearly slidable relative to the target tissue.

Abstract: A laser treatment apparatus is provided with a treatment probe, an observation probe, an image processing section, a lesion disappearance degree judgment section, and a CPU. The treatment probe and the observation probe are disposed in a catheter inserted into a blood vessel. The observation probe scans an inner wall of the blood vessel to obtain a tomographic image signal therefrom. The image processing section produces a tomographic image from the tomographic image signal. The lesion disappearance degree judgment section analyzes the tomographic image and judges whether or not a lesion exists. The CPU controls radiation of a laser beam from the treatment probe based on a judgment result of the lesion disappearance degree judgment section.

Abstract: There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

Abstract: A catheter tip is provided according to various embodiments of the disclosure. The catheter tip may comprise a distal end, a proximal end, and tubular walls. The distal end includes a distal aperture with a distal inside diameter, and the proximal end includes a proximal aperture with a proximal inside diameter. The proximal inside diameter may be greater than the distal inside diameter. The proximal end comprises attachment means configured to couple the proximal end with a distal end of a laser catheter. The tubular walls may include at least an inside taper from the proximal end to the distal end such that the inner tubular walls generally taper from the proximal inside diameter to the distal inside diameter. Moreover, the tubular walls may be configured to direct at least a liquid medium, for example, a biocompatible solution, toward the distal aperture.