Tip Or Other Cooling Concentration Means Patents (Class 606/23)
  • Patent number: 10285749
    Abstract: A method, system, and device for predicting lesion quality. Specifically, lesion quality may be predicted based on an assessment of pulmonary vein occlusion using saline injection and evaluation of temperature measurements recorded by a thermocouple located distal to the cryoballoon of the treatment device. The quality of the occlusion may be rated based on the time it takes the temperature recorded by the thermocouple to increase from approximately 2° C. to approximately 38° C., the rate of temperature change over a predetermined time period, and/or the rate of dissipation within the pulmonary vein of the saline with a volume of contrast medium. For example, the quality of the occlusion may be rated as being good, fair, or poor. This assessment may be quickly and easily communicated to an operator.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: May 14, 2019
    Assignee: Medtronic Cryocath LP
    Inventor: Boaz Avitall
  • Patent number: 10251777
    Abstract: A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor, and an outer sheath or guide. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: April 9, 2019
    Assignee: Nuvue Therapeutics, Inc.
    Inventor: Patrick LePivert
  • Patent number: 10018456
    Abstract: An open-loop thermal control system and method for components that generate heat includes a reservoir for containing a pressurized working fluid, a first heat exchanger in thermal communication with the working fluid, a Joule-Thomson expansion valve in fluid communication with the reservoir, and a second heat exchanger in fluid communication with the valve. The first heat exchanger is configured to transfer heat from the components to the fluid in the reservoir. The valve is configured to expand the working fluid into a two-phase fluid having a primary use of cooling. The second heat exchanger is configured to receive heat from the components and receive the two-phase fluid. The second heat exchanger provides a single-phase working fluid for at least one secondary use before the working fluid is expelled from the thermal control system.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 10, 2018
    Assignee: RAYTHEON COMPANY
    Inventors: Paul M. Lyons, Jeremy C. Danforth, Jeff L. Vollin, Matt H. Summers
  • Patent number: 9801677
    Abstract: Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: October 31, 2017
    Assignee: THe General Hospital Corporation
    Inventors: Richard R. Anderson, Dieter Manstein
  • Patent number: 9522030
    Abstract: A method for purging a cryotreatment system, in particular, for clearing moisture and thus preventing ice blockages within a fluid flow path that may be formed when moisture pockets within the fluid flow path of the system are encountered by a first injection of refrigerant at the beginning of a cryotreatment procedure. The method may include injecting refrigerant from a refrigerant source into a fluid delivery conduit at a preselected pressure for a first period of time, the refrigerant flowing from the fluid delivery conduit through a fluid injection element and into a fluid recovery conduit, and evacuating refrigerant from the fluid recovery conduit by vacuum pressure generated by the vacuum pump for a second period of time. This method may be repeated for a plurality of cycles.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: December 20, 2016
    Assignee: Medtronic CryoCath LP
    Inventors: Chadi Harmouche, Rachid Mahrouche, Eric Monger, Bertin Siméon, Vladimir Tzonev
  • Patent number: 9445860
    Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 20, 2016
    Assignee: Channel Medsystems, Inc.
    Inventors: Daniel R. Burnett, Ric Cote, William W. Malecki, Brian M. Neil, David Beaulieu, Benjamin D. Voiles
  • Patent number: 9408654
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: August 9, 2016
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Patent number: 9339322
    Abstract: Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: May 17, 2016
    Assignee: Boston Scientific Scimed Inc.
    Inventor: Daniel M. Lafontaine
  • Patent number: 9320559
    Abstract: Ablation devices useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe comprising an interior surface that defines an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. A release instrument is provided comprising a sheath that comprises an exterior surface and an interior surface configured for engagement with the probe. The probe tip is configured for ablating nerve and/or soft tissue by forming an ice ball and the release instrument is configured to release the probe tip from the ice ball. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: April 26, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9320528
    Abstract: An ultrasonic surgical tool has probe body with an operative surface or edge contactable with organic tissues for performing a surgical operation on the tissues. A shank of the probe body is provided with a connector for operatively attaching the tool to a source of ultrasonic mechanical vibrational energy. The shank and a portion of the probe body are formed with a channel for fluid delivery to the probe body. At least a portion of the probe body located between the channel and the operative surface or edge has a microporous or sintered structure enabling fluid penetration to the operative surface or edge from the channel.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: April 26, 2016
    Assignee: MISONIX, INCORPORATED
    Inventors: Dan Voic, Ronald Manna, Alexander Darian, Scott Isola
  • Patent number: 9314560
    Abstract: An apparatus for heating a medical fluid includes a fluid passage for delivering the medical fluid, a heating element for heating the medical fluid, and a detector. The detector has a first detector for detecting a parameter which correlates with a flow rate of the medical fluid, or a second detector for detecting a parameter which corresponds to a set point, for the flow rate of the medical fluid. A controller controls regulates a temperature of the medical fluid in the fluid passage and a temperature of the heating element, and a switching circuit switches the controller between controlling or regulating the temperature of the medical fluid and controlling or regulating the temperature of the heating element. The switching circuit is configured such that the switching is triggered in response to the switching circuit detecting that the flow rate falls below or exceeds a predetermined flow rate threshold value.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: April 19, 2016
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Christoph Wiktor
  • Patent number: 9144431
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: September 29, 2015
    Assignees: AEGIS MEDICAL INNOVATIONS INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
  • Patent number: 9113925
    Abstract: A method of performing an ablation procedure includes the initial step of supplying a fluid to a cooling chamber defined within an antenna assembly. The method also includes the steps of decreasing the temperature of the fluid to form a solid material and inserting the antenna assembly into tissue. The method also includes the step of supplying energy to the antenna assembly to treat tissue. Residual heat from the antenna assembly transitions the solid material back to the fluid. The method also includes the step of circulating the fluid within the antenna assembly to dissipate heat emanating from the antenna assembly.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: August 25, 2015
    Assignee: Covidien LP
    Inventors: Ian S. Smith, Darion Peterson, Kenlyn S. Bonn
  • Patent number: 9072498
    Abstract: Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: July 7, 2015
    Assignee: MYOSCIENCE, INC.
    Inventors: Lisa Elkins, Ronald Williams
  • Patent number: 9039689
    Abstract: A cryosurgical instrument including: a core, a cryogen delivery tube, a cryogen return tube, and a shaft surrounding the core and the tubes. The shaft has a pointed distal end and a proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen. The cryogen delivery tube and the cryogen return tube both have respective helical portions that spiral around the core. The helical portions of the tubes are in fluid tight contact with the core and an inner surface of the shaft. The helical portions of the tubes spiral about the core in an alternating arrangement such that they alternate along a length of the core. The core and the helical portions of the delivery tube and the return tube comprise centrifugal phase separators.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: May 26, 2015
    Assignee: ICECURE MEDICAL LTD.
    Inventors: Nir Berzak, Ron Hilleli
  • Patent number: 9033967
    Abstract: Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: May 19, 2015
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: Daniel M. Lafontaine
  • Publication number: 20150133905
    Abstract: There is provided a method of supplying cryoenergy to a plaque within a blood vessel. The method comprises expanding an expandable membrane of a catheter apparatus with a pressure of less than 5 ATM (507 kPa), the catheter apparatus having been placed in thermal contact with the plaque within the blood vessel. The method also comprises establishing a temperature of between +15° C. (288K) and ?35° C. (238K) at an interface of the expandable membrane and the blood vessel. A system and catheter apparatus are also provided.
    Type: Application
    Filed: January 20, 2015
    Publication date: May 14, 2015
    Inventors: Maurice Buchbinder, Randell Louis Werneth, Yiannakis Petrou Yianni, J. Christopher Flaherty, Daniel Nahon, Domenic Santoianni
  • Publication number: 20150126986
    Abstract: Embodiments related to cryogenically ablating a portion of the inner surface of a vessel by constraining a cryoballoon using various apparatuses and methods are disclosed. For example, a catheter can include a cryoballoon for ablation of the vessel wall and a constraining element disposed substantially in parallel with the cryoballoon to deflect or offset a portion of the cryoballoon away from non-target tissue of the vessel wall and prevent ablation of the non-target tissue. Partial circumferential, non-continuous, or helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The constraining element may be, for example, a second inflatable balloon or one or more self-expanding prongs.
    Type: Application
    Filed: April 25, 2012
    Publication date: May 7, 2015
    Applicant: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Brian Kelly, John Kelly, Gary Kelly, Barry Mullins
  • Patent number: 9023023
    Abstract: Ablation devices useful for removing nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a plurality of probes each comprising an interior surface defining an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. A plurality of introducers are provided each comprising an interior surface configured for engagement with the probe where at least one air gap is produced by the introducer and probe engagement and an exterior surface comprising a heat conductive tip where the probe tip is snap fixed with the introducer tip in a configuration for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 5, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Josee Roy
  • Publication number: 20150112195
    Abstract: Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about ?15° C. to about ?30° C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.
    Type: Application
    Filed: October 10, 2014
    Publication date: April 23, 2015
    Inventors: Abraham BERGER, Avri HAZAN
  • Publication number: 20150105764
    Abstract: A cryotherapy balloon catheter includes a compliant cryotherapy balloon comprising a distal balloon section dimensioned for placement within a renal artery and a proximal balloon section dimensioned to abut against an ostium of the renal artery and extend into at least a portion of the abdominal aorta. The compliant balloon has a diameter that varies non-uniformly along a length of the compliant balloon, such that a diameter at the proximal balloon section is larger than a diameter of the distal balloon section. The cryotherapy balloon catheter may be configured to deliver cryogenic therapy to at least the ostium of the renal artery sufficient to irreversibly terminate renal sympathetic nerve activity, such as by causing neurotmesis of renal nerve fibers and ganglia at the ostium of the renal artery.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: RAED N. RIZQ, ROGER N. HASTINGS, DAVID J. SOGARD
  • Patent number: 8986293
    Abstract: A catheter based medical device including controlled refrigerant dispersion is disclosed. The device includes a fluid injection tube that carries refrigerant from a coolant supply to the distal portion of the device. An open distal end or one or more orifices may be provided on the injection tube for the refrigerant to be expelled into an expandable chamber such as a balloon disposed on the distal portion of the catheter. The dispersion of the refrigerant from the injection tube may be controlled or manipulable to direct the refrigerant to one or more target locations.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: March 24, 2015
    Assignee: Medtronic Cryocath LP
    Inventor: Gilles Desrochers
  • Publication number: 20150080871
    Abstract: A cryosurgical instrument including: a core, a cryogen delivery tube, a cryogen return tube, and a shaft surrounding the core and the tubes. The shaft has a pointed distal end and a proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen. The cryogen delivery tube and the cryogen return tube both have respective helical portions that spiral around the core. The helical portions of the tubes are in fluid tight contact with the core and an inner surface of the shaft. The helical portions of the tubes spiral about the core in an alternating arrangement such that they alternate along a length of the core. The core and the helical portions of the delivery tube and the return tube comprise centrifugal phase separators.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventors: Nir BERZAK, Ron HILLELI
  • Publication number: 20150080794
    Abstract: A fluid purging system has a spring-energized relief valve having an inlet port that is coupled to a fluid chamber to receive incoming fluid, and an outlet port through which incoming fluid is relieved. The outlet port is fluidly coupled to a pressurized chamber. The fluid purging system also includes an electro-mechanical pressure switch, and an electrically operated solenoid valve which functions as a pressure exhaust valve. The pressure switch and the solenoid valve are in fluid communication with the pressurized chamber.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 19, 2015
    Applicant: HORIZON SCIENTIFIC CORP.
    Inventors: Thach Buu Duong, Min Frank Zeng
  • Publication number: 20150080870
    Abstract: A medical device, including an elongate body having a proximal portion and a distal portion; a shaft at least partially disposed within the elongate body; an expandable element at the distal portion of the elongate body; and a fluid delivery conduit defining a deflectable segment movably coupled to the shaft, the deflectable segment being transitionable from a substantially linear configuration to a substantially curvilinear configuration.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventor: Dan WITTENBERGER
  • Patent number: 8945106
    Abstract: A cryogenic probe design is provided containing, for example, an inner coil injection tube with a continuous flow of circulating liquid and an outer jacket enclosing the inner coil injection tube. A transducer may monitor parameters in the region between the inner coil injection tube and the outer jacket. An outer jacket serves to prevent gas leakage. One or more embodiments of a probe design provide continuous flow for example via a continuous and controlled path from inlet to outlet and an expanded thermally transmissive region. Expanding a thermally transmissive region of the cooling zone may be provided, for example, in one or more embodiments of injection tube designs.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: February 3, 2015
    Inventors: Steve Arless, Daniel Nahon, Domenic Santoianni
  • Patent number: 8939968
    Abstract: A cryosurgical instrument, comprising a cryoprobe having ducting through which a compressed cooling fluid, such as a cooling gas, flows, for cooling a least part of the cryoprobe. The ducting has an expansion channel having a channel cross-section that enlarges progressively in the flow, direction over a predetermined length such that the compressed cooling gas gradually decompresses, at least partially, beyond a predetermined length on its flow path through the expansion channel while simultaneously cooling down.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: January 27, 2015
    Assignee: Erbe Elektromedizin GmbH
    Inventor: Franz Geiselhart
  • Publication number: 20140371732
    Abstract: Apparatus for applying thermotherapy to a part of the human or animal body comprising an applicator having a flexible enclosure in which thermal energy transfer fluid can circulate, a connector for connecting the applicator to a control system, an interface layer for providing a thermally conductive interface between the flexible enclosure and a treatment site and, an electrically conductive supporting layer for supporting the interface layer and capable of being energised by an electrical signal from the control system to improve the thermal conductivity of the interface layer. The apparatus also includes a valve unit for connecting the applicator to a control system, a heat exchanger for cooling a thermal energy transfer fluid and a control system for controlling the application of thermotherapy.
    Type: Application
    Filed: June 5, 2014
    Publication date: December 18, 2014
    Inventor: Nicholas James Rose
  • Patent number: 8911434
    Abstract: A medical device, including an elongate body having a proximal portion and a distal portion; a shaft at least partially disposed within the elongate body; an expandable element at the distal portion of the elongate body; and a fluid delivery conduit defining a deflectable segment movably coupled to the shaft, the deflectable segment being transitionable from a substantially linear configuration to a substantially curvilinear configuration.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: December 16, 2014
    Assignee: Medtronic CryoCath LP
    Inventor: Dan Wittenberger
  • Patent number: 8906005
    Abstract: A cryo-surgical system may comprise a container containing a refrigerant, a delivery tube having a first end configured to be in flow communication with the container and a second end opposite the first end. The system may further include a plurality of flexible finger portions disposed proximate a second end of the delivery tube opposite the first end, an applicator bud having a body portion disposed within the plurality of flexible finger portions and a contact surface extending from the plurality of flexible finger portions. An adjustment ring may be disposed along the delivery tube adjacent to the plurality of flexible finger portions. The contact surface of the bud may be changeable by adjustment of the adjustment ring.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: December 9, 2014
    Assignee: Orasure Technologies, Inc.
    Inventor: Philip Michael Formica
  • Patent number: 8906004
    Abstract: A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along longitudinal axis thereof. The cryogen delivery tube, at least where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft. The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging, through boiling, occurs close to the external wall of the instrument.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: December 9, 2014
    Assignee: Icecure Medical Ltd.
    Inventors: Nir Berzak, Ron Hilleli
  • Publication number: 20140358137
    Abstract: A system and method for occluding a pulmonary vein. The device includes a treatment device comprising an inner balloon, an outer balloon, and a space therebetween. Delivery of fluid to the inner balloon inflates the treatment element to a first diameter. If a greater treatment element diameter is required to completely occlude a pulmonary vein, fluid is delivered to the space between the first and second balloons, which expands the second balloon and causes the treatment element to have a second diameter that is greater than the first diameter. The fluid delivered to the inner balloon and fluid delivered to the space between the balloons may be from different sources and may be delivered and exhausted independently. Once the treatment element is caused to have a diameter sufficient to completely occlude the pulmonary vein, the treatment element is activated to cool or heat ostial tissue.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 4, 2014
    Inventor: Yixin HU
  • Patent number: 8888768
    Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: November 18, 2014
    Assignee: CryoMedix, LLC
    Inventors: Alexei Babkin, Peter Littrup, William Nydam, Barron Nydam
  • Patent number: 8882755
    Abstract: A novel medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: November 11, 2014
    Assignee: Kimberly-Clark Inc.
    Inventors: Mark Leung, Krishan Shah, Laura Conquergood, Subashini Chandran
  • Publication number: 20140316399
    Abstract: The invention relates to a medical device, including interchangeable parts thereof, for performing corneal cell freezing wherein said device comprises an elongate member having a flow line system through which a cryogenic fluid flows to cool a cryoprobe tip which tip is fixed and comprises a concave epithelial surface contact member.
    Type: Application
    Filed: September 6, 2012
    Publication date: October 23, 2014
    Applicant: University College Cardiff Consultants Limited
    Inventor: Andrew Quantock
  • Patent number: 8858543
    Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: October 14, 2014
    Assignee: Channel Medsystems, Inc.
    Inventors: Daniel R. Burnett, Ric Cote, William W. Malecki, Brian M. Neil, David Beaulieu, Benjamin D. Voiles
  • Patent number: 8845627
    Abstract: A cryotherapy catheter can include an elongate member and an inflatable balloon at a distal end of the elongate member, the elongate member having lumens formed therein to supply cryogenic fluid to a chamber of the balloon and to channel exhaust from the balloon chamber; and a controller programmed to control a first rate at which the cryogenic fluid is supplied to the balloon chamber and a second rate at which exhaust is channeled from the balloon chamber, wherein the controller is programmed to a) develop, during a first phase of a cryotherapy procedure, a first pressure inside the balloon chamber at a value that is greater than an ambient pressure outside and adjacent to a proximal end of the elongate member, and b) develop, during a second phase of the cryotherapy procedure, the first pressure at a value that is less than the ambient pressure.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: September 30, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Leonard J. George, Joann Heberer
  • Patent number: 8845628
    Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: September 30, 2014
    Assignee: CryoMedix, LLC
    Inventors: Alexei Babkin, Peter Littrup, William Nydam, Barron Nydam
  • Publication number: 20140276709
    Abstract: A medical system, comprising an ablation catheter is disclosed. The ablation catheter includes an elongate shaft with a proximal end, a distal end and a lumen disposed between the proximal end and the distal end. The ablation catheter also includes an expandable element in fluid communication with the lumen, a first temperature sensor operable to measure a first temperature; and a second temperature sensor operable to measure a second temperature. The first temperature sensor and the second temperature sensor are longitudinally separated from each other by at least a portion of the expandable element.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: MEDTRONIC CRYOCATH LP
    Inventors: Dan WITTENBERGER, Rachid MAHROUCHE
  • Publication number: 20140276539
    Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 18, 2014
    Applicant: MyoScience, Inc.
    Inventors: John Allison, Richard Radnovich, Jason Reynolds
  • Publication number: 20140243808
    Abstract: The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 28, 2014
    Applicant: CPSI HOLDINGS LLC
    Inventors: Marie Molnar-Hammond, John M. Baust
  • Patent number: 8771264
    Abstract: A medical apparatus and system for determining contact assessment includes a catheter having an elongate body having a proximal end, a distal end opposite the proximal end, and defining an injection lumen and an exhaust lumen, an expandable membrane defining a cooling chamber disposed at a point along the elongate body, the cooling chamber in fluid communication with the injection lumen and the exhaust lumen, and a contact assessment element which may be a temperature sensor located proximate the coolant return lumen for measuring an internal temperature of the chamber. The system may include the catheter, a console having a fluid supply, an exhaust path and at least one control mechanism operationally coupled to the temperature sensor for processing a temperature signal received from the temperature sensor. The apparatus and system can also have multiple electrodes to measure and process various impedances to determine contact assessment.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 8, 2014
    Assignee: Medtronic CryoCath LP
    Inventors: Marwan Abboud, Teresa Ann Mihalik, Johnny Al Asmar, Chadi Harmouche
  • Patent number: 8764740
    Abstract: Systems, apparatus and methods for dispersing a coolant along different portions of a supply tube of a cryo-ablation device which may be in the form of a linear ablation device or catheter probe or a balloon catheter. A supply tube includes multiple tubes that are in fluid communication with an inner space of a transmissive region or an inner space of an inflatable balloon. The tubes are coaxially arranged and extend to different lengths or to different locations such that the coolant is dispersed from different tubes at different axial locations. Annular apertures are defined by pairs of tubes and have different sizes. The tubes and arrangement thereof are structured to provide uniform or substantially uniform coolant distribution to provide uniform or substantially uniform cryo-ablation of surrounding tissue.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: July 1, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: James R. Watson
  • Patent number: 8747396
    Abstract: A cryosurgical probe assembly that includes a gas delivery assembly, including a stem and a fluid conduit subassembly bonded to the stem. The fluid conduit subassembly delivers and returns cooling fluid used for cryogenic cooling. The fluid conduit subassembly, comprises a shaft for providing a heat exchange surface for cryogenic ablation; a housing securely connected to said shaft; and, an insulation element slideably engaged with an inner surface of the shaft and slideably engaged with the stem. The cryosurgical probe assembly includes an adjustable sliding apparatus that includes a slider assembly securely attached to said insulation tube for slideably guiding the insulation tube along said shaft; and, a button assembly operatively connected to the slider assembly for allowing a user to actuate the slider assembly to provide a desired adjustment of the insulation tube relative to the shaft. A handle assembly is positioned about the housing.
    Type: Grant
    Filed: October 18, 2009
    Date of Patent: June 10, 2014
    Assignee: Endocare, Inc.
    Inventors: Thach Duong, Jay J. Eum
  • Patent number: 8740892
    Abstract: An expandable, flexible multi-tubular cryoprobe operational with a near critical cryogenic working fluid. The inlet fluid transfer micro-tubes utilized are formed of material that maintains flexibility in a full range of temperatures from ?200° C. to ambient temperature. During operation, the cryoprobe is mechanically actuated to provide radial expansion of the inlet fluid transfer micro-tubes. Thus, enhanced thermal contact with target biological tissue to be treated is provided.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: June 3, 2014
    Assignee: Endocare, Inc.
    Inventors: Alexei V. Babkin, Anatoly I. Efremov, Jay J. Eum
  • Patent number: 8740891
    Abstract: A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from ?200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: June 3, 2014
    Assignee: Endocare, Inc.
    Inventors: Alexei V. Babkin, Peter J. Littrup, Robert V. Duncan, William J. Nydam
  • Publication number: 20140142559
    Abstract: A balloon elongation apparatus includes an elongated hypotube with a distal end having a reduced inner diameter portion that is configured to radially expand when a mandrel is advanced through a lumen of the hypotube towards the reduced inner diameter portion. A medical kit includes a catheter having a distally-located balloon and the elongation apparatus disposed within a guide wire tube of the catheter. In use, the balloon is elongated following a procedure in order to facilitate retracting the balloon into a sheath. The balloon is elongated by first advancing the mandrel relative to the hypotube so that the hypotube radially expands and firmly engages an inner surface of the guide wire tube and then advancing the mandrel, hypotube, and distal end of the guide wire tube relative to the catheter body.
    Type: Application
    Filed: January 28, 2014
    Publication date: May 22, 2014
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: JAMES R. WATSON
  • Patent number: 8727983
    Abstract: A catheter-based medical device includes a catheter that is configured and arranged for at least partial insertion into a patient and that defines at least one lumen that is configured and arranged to receive a first fluid. A conductive-fluid detector is coupled to the at least one lumen and is configured and arranged to detect when a second fluid is disposed within the at least one lumen that is more conductive than the first fluid. The conductive-fluid detector includes a plurality of axially-positioned bodies, each body defining a lumen. The lumens of the axially-positioned bodies are aligned to form a shared lumen in fluid communication with the at least one lumen of the catheter. Spaced apart electrodes are disposed within the shared lumen.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: May 20, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Charlotte F. Kinnison
  • Publication number: 20140135754
    Abstract: A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end adapted and configured to receive an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger. The heat exchanger includes: a plurality of cryogen delivery tubes that spiral around a longitudinal axis thereof; and a diffuser having a plurality of branches, each of the branches supplying received cryogen to a respective one of the delivery tubes. The cryogen delivery tubes, where they spiral, are spaced from each other and in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft.
    Type: Application
    Filed: December 19, 2013
    Publication date: May 15, 2014
    Applicant: IceCure Medical Ltd.
    Inventors: Nir BERZAK, Ron HILLELI
  • Patent number: 8715274
    Abstract: A method of performing a cryotherapy procedure can include introducing a cryotherapy balloon catheter at a treatment site inside a patient's body; regulating, during a first phase of a cryotherapy procedure, flow of cryogenic fluid to and exhaust from a distal balloon portion of the cryotherapy balloon catheter to cause an initial pressure to be maintained inside the distal balloon portion that is sufficiently high to cause an outer wall of the distal balloon portion to be pressed against body tissue at the treatment site; and regulating, during a second phase of the cryotherapy procedure, flow of cryogenic fluid to and exhaust from the distal balloon portion to cause a) a temperature inside the distal balloon portion to reach a value sufficient to deliver therapeutic levels of cryotherapy to the body tissue, and b) a second-phase pressure to be maintained that is within a threshold value of the initial pressure.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: May 6, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: James R. Watson