Abstract: An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a duct, to shrink, damage, or occlude the duct. In some embodiments, the energy can be applied with a vapor media. In some embodiments, the duct can be a ductus deferens or an ejaculatory duct of the male reproductive system. Another feature of the energy delivery probe is that it can utilize an inflatable member to form a seal to contain the vapor media. Methods associated with use of the energy delivery probe are also covered.

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localised ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract: Hair is permanently removed from a patient's skin by transcutaneously focusing high intensity acoustic energy at hair follicles and at dermal papilla regions during a telogen phase of hair growth and applying sufficient energy to destroy said follicles and said dermal papilla regions, so that hair is removed and regrowth is prevented. Typically, a region of a patient's skin is first ultrasonically imaged to show the location of a plurality of individual hair follicles and dermal papilla regions. The imaged hair follicles and dermal papilla regions are then treated using a system which automatically directs high intensity acoustic energy at each follicle and dermal papilla region.

Abstract: Devices and methods are provided for ablational treatment of regions of the digestive tract in post-bariatric surgery patients who fail to achieve or maintain the desired weight loss. Bariatric procedures include Roux-en-Y gastric bypass, biliopancreatic diversion, and sleeve gastrectomy. These procedures reconstruct gastrointestinal tract features, creating pouches, stoma, and tubes that restrict and/or divert the digestive flow. Post-surgical dilation of altered structures is common and diminishes their bariatric effectiveness. Ablation of compromised structures can reduce their size and compliance, restoring bariatric effectiveness. Ablation, as provided the invention, starts at the mucosa and penetrates deeper into the gastrointestinal wall in a controlled manner. Control may also be provided by a fractional ablation that ablates some tissue within a target region and leaves a portion substantially unaffected.

Abstract: A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered.

Abstract: A thermochemical ablation system can be used to ablate a portion of a bodily structure, such as a human airway. In some examples, the thermochemical ablation system includes a first ablation reagent, a second ablation reagent, and an expandable balloon positioned adjacent the distal end of a catheter. The expandable balloon can be inserted into the bodily structure and the two ablation reagents combined to cause an exothermic reaction that generates heat. The heat may create a substantially uniform temperature distribution across the surface of the expandable balloon, providing substantially uniform ablation of tissue adjacent the balloon.

Abstract: A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart.

Abstract: Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Abstract: A device 1a for bonding adherends T1 and T2, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping part 2a for clamping the adherends T1 and T2 between members 21a and 22a; a pressing part 3a for pressing the member 22a towards the member 21a; a pressure control part 4a for controlling the pressure by the pressing part 3a; a heating element 5a built into the member 21a; a heating control part 6a for controlling the heating by the heating element 5a; a vibration generating part 7a for generating microvibration; and a vibration control part 8a for controlling the microvibration generated by the vibration generating part 7a.

Abstract: A system for ablating tissue includes a reusable control unit including a processor monitoring and controlling ablation and a control interface receiving input to and output from the processor in combination with a disposable procedure set releasably connectable to the control unit to couple to the control interface for communication with the processor.

Abstract: A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element.

Abstract: A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

Abstract: A catheter or lead having electrically conductive traces and external electrical contacts. Each trace may be in electrical connection with one or more external electrical contacts. More specifically, each trace is typically electrically connected to a single contact. The traces and contacts may assist in diagnosis and/or detection of bio-electrical signals emitted by organs, and may transmit such signals to a connector or diagnostic device affixed to the catheter. The external electrical contacts may detect bioelectric energy or may deliver electrical energy to a target site.

Abstract: A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract: A cardiac ablation device, including a steerable catheter (10) and an expandable ablation element (18) incorporating one or more balloons (20, 22) at the distal end of the catheter, has a continuous passageway (28, 30) extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. A probe (72) carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop (82) which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the sensor probe.

Abstract: In some embodiments the method includes inserting an access tool through a cervix and a cervical canal into the uterus; placing an expansion mechanism in contact with tissue within the uterus to move uterine tissue surfaces away from an opening in an access tool lumen; delivering vapor through the vapor delivery tool into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool adapted to be inserted through a cervical canal to place an opening of an access tool lumen within a uterus; an expansion mechanism adapted to be advanced into the uterus to move uterine tissue surfaces away from the opening in the access tool lumen; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: A method and device for assessing, and treating patients having sympathetically mediated disease, such as cardiac, metabolic, or pulmonary disease involving chemoreceptor hyperactivity and heightened sympathetic tone by reducing chemosensor input to the nervous system.

Abstract: A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length. The invention provides an ablation apparatus and methods for ablating tissue wherein the ablation apparatus may have ablating elements that are moveable relative to the tissue to be ablated without the need to relocate the apparatus as a whole.

Abstract: The present description relates to fluid sealant compositions that increase in viscosity upon administration to a subject, to medical procedures employing such compositions, to methods for administering such compositions, and to products containing such compositions including medical devices, medical device components and kits, among other aspects.

Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

Abstract: A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer.

Abstract: A mammal undergoing an energy-based therapy is treated by administering at least one vasoconstrictive agent to the mammal prior to or during the procedure. The at least one vasoconstrictive agent is added in amounts sufficient to reduce or prevent vasodilation. This treatment method increases or promotes the size of the coagulation zone created after energy-based therapy.

Abstract: An electrical surgical cautery device for delivering thermal energy to cauterize and provide hemostasis to a bleeding tissue comprises an electrically powered flexible thermal delivery element having a substantially planar resistive coil embedded in a thermally conductive material. The thermally conductive material comprises a tissue contact surface and a non-tissue contact surface. A power source is connected to the resistive coil of the thermal delivery element and provides an electrical current to heat the thermal delivery element being pressed against the tissue. A method for providing hemostasis to a bleeding tissue surface comprises providing and pressing an electrical cautery device having a thermal delivery element, against the hemorrhaging tissue at a predetermined temperature for an interval sufficient to cauterize the tissue and provide hemostasis.

Abstract: Core-excited nanoparticle thermotherapy (CENT), is an improved material for use in thermotherapy. The CENT method uses both core-exciting energy (including x-rays) and core-shell nanoparticles, specifically designed to absorb radiation in their core structure, then transfer energy from the core to the shell, to heat the outer shell of the nanoparticle. The heated nanoparticle then heats the surrounding region to a temperature sufficient to detect, affect, damage and/or destroy the targeted cell or material. CENT nanoparticles can be bound to targeting agents that deliver them to the region of the diseased cell.

Abstract: A method is provided for establishing contact of a medical device against a tissue surface within a subject body, the method comprising determination of the geometrical configuration of the distal portion of the medical device, and using this together with known control variable information to determine and control the contact force of the distal tip of the medical device against the tissue surface.

Abstract: Disclosed herein is a medical device including: a positioning catheter to be inserted into a blood vessel in the vicinity of an affected region; a treatment catheter to be inserted to reach the affected region; and attracting means provided at respective predetermined positions of both the catheters to apply a magnetic force in a direction of attracting each other; wherein the magnetic force of the attracting means restricts floating of the treatment catheter.

Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure sensing elements which may allow for control of the pressure within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled or room temperature fluid such as water may then be used to rapidly terminate the treatment session.

Abstract: Provided is a coagulation apparatus using cold plasma. In the coagulation apparatus, the cold plasma is generated by a microwave resonator with low power consumption in the atmosphere, and the cold plasma is vented on a bleeding portion of a wound. Accordingly, it is possible to accelerate coagulation process, to reduce unfavorable side effect such as burns on the wound, and to efficiently sterilize the wound, simultaneously. In addition, it is possible to implement a small-sized portable coagulation apparatus.

Abstract: A surgical instrument for delivering energy to lung tissue, for example to cause lung volume reduction. In one embodiment, an elongated catheter has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid media under pressure. An energy source delivers energy to the media to cause a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the catheter. The delivery of energy and the flow of vapor are controlled by a computer controller to cause a selected pressure and selected volume of vapor to propagate to the extremities of the airways. Contemporaneously, the vapor undergoes a vapor-to-liquid phase transition which delivers large amount of energy to the airway tissue. The thermal energy delivered is equivalent to the heat of vaporization of the fluid media, which shrinks and collapses the treated airways.

Abstract: Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.

Abstract: Methods, apparatus, and systems for occluding a left atrial appendage are provided. One embodiment includes an elongate body having a tissue apposition member extendably positioned within a lumen of the elongate body to appose tissue of the LAA. An energy emitting device coupled to the elongate body can be used for emitting high intensity focused ultrasound to the tissues to fuse the tissues.

Abstract: A method and apparatus are provided for treating connective tissue. The method and apparatus can be used for treating and/or reducing the appearance of cellulite.

Abstract: A system and tool for performing a capsulotomy procedure. The system includes an air pressure unit providing pressurized airflow, a capsulotomy and movement control unit providing electrical current and movement control, and a capsulotomy tool including a main housing, and an extendable-retractable burning element coupled to the main housing. The tool is in connection with the capsulotomy and movement control unit for providing electrical current to the burning element and movement control for extending and retracting the burning element. When the burning element is in a flattened, retracted configuration, the tip of the tool can be inserted through a relatively small corneal incision. Once in the anterior chamber, the burning element is switched to a circular, extended configuration, so as to allow performance of a capsulotomy by applying an electrical pulse to the burning element.

Abstract: A system and method for controlling one or more medical devices by a remote console. The remote console communicates wirelessly with a central control unit that connects to one or more of the medical devices. To conserve battery power and simplify operation, the remote console is configured to automatically power on and initiate a wireless connection in response to being brought into proximity of the central control unit. According to another embodiment, the remote console automatically powers on and terminates any previously established wireless connections when brought into proximity of the central control unit.

Abstract: A method for ablating tissue comprising controlling a heating element using a variable phase angle control to heat an ablation fluid to a desired temperature and determining a heating percentage corresponding to a percentage of a maximum available heating power represented by a current level of power supplied to the heating element and, when the heating percentage remains below a threshold level for a predetermined period of time, indicating a flow obstruction condition of the fluid.

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

Abstract: Thermally adjustable surgical tools include a conductor and a ferromagnetic material. The ferromagnetic material may be quickly heated when subjected to high frequency alternating current through the conductor. The ferromagnetic material may also cool rapidly because of its relatively low mass and the small thermal mass of the conductor. The thermally adjustable surgical tools may be used to sculpt, melt, break and/or remove biological material. The thermally adjustable surgical tools may also include balloon catheters which can heat fluid to thereby treat biological material.

Abstract: This invention relates to surgical instruments for applying energy to tissue using a vapor-to-liquid phase transition which delivers large amount of energy to the targeted tissue. In one embodiment, the system is configured for volumetric removal of tissue by means of high velocity ejection of a vapor media from a first vapor port proximate to soft tissue wherein the vapor-to-liquid phase change of the media applies energy to the tissue. The system provides a second port coupled to a suction source that cooperates with the first vapor port to suction tissue debris from the targeted site.

Abstract: The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Abstract: A method and system for delivering energy to affect the signs of aging is described. Energy is delivered to a target volume of a muscle such that the energy creates a lesion in the target volume. A characteristic of the lesion is controlled to affect movement of the muscle.

Abstract: Featured is a catheter device for ablating tissue that includes an elongated body member having a distal portion and a deflection mechanism operably coupled to the distal portion so as to cause the distal portion to deflect with respect to a longitudinal axis of the elongated body member. Such a catheter device also includes a guide member and a guiding mechanism that is coupled to the elongated body member and is configured so as to guide the guide member. The guiding mechanism includes an exit portion from which the guide member exits during deployment. The exit portion is disposed with respect to the distal portion end so the distal portion deflects from and with respect to the guide member as well as rotating about the guide member. Also featured are systems and methods related thereto.

Abstract: Microwave antenna assemblies incorporating a resilient insulating coupler are described herein. The microwave antenna includes a radiating portion connected by a coaxial feedline to a power generating source, e.g., a generator. Distal and proximal radiating portions of the antenna, which correspond to inner and outer conductors provided by the coaxial feedline, are separated by the resilient insulating coupler. The described coupler includes a proximal threaded portion, and an overmolded insulating portion formed from an elastomeric material. The inner conductor of the coaxial feedline is joined to the threaded portion of the coupler, and is placed under tension to draw together the distal radiating portion, the coupler, and the proximal radiating portion into a single rigid assembly. In use, the resilient coupler provides increased strength and reliability by absorbing mechanical stresses typically encountered during microwave ablation procedures.

Abstract: An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

Abstract: A method of minimizing thermal trauma during tissue ablation includes the steps of placing an ablation catheter at an ablation site on a first organ in a patient's body, providing energy to the ablation catheter to heat first organ tissue at the ablation site, providing microwave radiometry apparatus including a probe containing a microwave antenna and a radiometer responsive to the antenna output for producing a temperature signal corresponding to the thermal radiation picked up by the antenna and positioning the probe in a body passage of a second organ in the patient's body having a wall portion adjacent to the ablation site so that the microwave antenna is located at a measurement site opposite the ablation site.

Abstract: The present invention generally relates to devices for harvesting a skin graft(s). The present invention provides a blister raising device integrated with a member for cutting the blister.

Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

Abstract: An elongate probe, with a suction channel extending longitudinally along the probe, is inserted into a patient so that a distal tip of the probe is in contact with a fibroid mass inside the patient. Thereafter the probe is ultrasonically vibrated so that the distal tip has an excursion amplitude or distance greater than 275 microns. During probe vibration, suction is applied to the channel at a vacuum level greater than 24? Hg to thereby maintain the target tissue mass in engagement with the distal tip during the vibrating of the probe and enable ablation of at least a selectable portion of the target tissue mass.