Abstract: Methods for therapeutic renal denervation are disclosed herein. One aspect of the present application, for example, is directed to methods that block, reduce and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry several therapeutic benefits across many disease states.

Abstract: This invention relates to medical instruments and systems for applying energy to tissue. Variations of the systems and methods described herein include ablating, sealing, and extracting tissue with high pressure flows of fluids that in part utilizes a vapor-to-liquid phase change of flow media to apply thermal energy to the tissue.

Abstract: The present invention relates generally to the treatment of atherosclerosis and thrombosis. Specifically, the invention relates to a method for removing vascular deposits by locally heating plaque sites with micron size particles that are administered intravenously and are heated inductively.

Abstract: The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract: An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Abstract: Apparatus and methods for insulating tissue during therapeutic procedures.

Abstract: Methods of treating a subject for a cardiac arrhythmia are provided. Aspects of the methods include thoracoscopically producing a cardiac Cox maze III set of lesions in cardiac tissue of the subject in a manner sufficient to treat the subject for the cardiac arrhythmia.

Abstract: A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including insulation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.

Abstract: A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer.

Abstract: A device for circulating fluid to a target site within a living body, comprises a longitudinal member including an inlet lumen supplying fluid to the target site and a return lumen withdrawing fluid from the target site, the return lumen surrounding the inlet lumen and a screen coupled to a distal end of the longitudinal member, the screen including a plurality of openings extending therethrough from a radially inner surface forming a radially outer wall of a distal portion of the return lumen to an outer surface thereof.

Abstract: Methods and devices for delivering energy to lung tissue, for example to cause lung volume reduction by generating a flow of vapor and introducing the flow of vapor into the lung where the vapor delivers thermal energy sufficient to modify lung tissue.

Abstract: A surgical instrument guide for facilitating treatment of a target tissue is provided. The surgical instrument guide may be placed between two groups of tissue such that a first group of tissue is cut and a second group of tissue is protected from being cut. The surgical instrument guide may lift tissue and slide tissue along a surface so that a target tissue may be cut to a desired depth more easily during a surgical procedure. The surgical instrument guide may be releasably attachable to a surgical instrument or integrally formed therewith.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a pre-determined distance into the prostate by an actuation mechanism. The actuation mechanism can comprise, for example, a spring, or at least one magnet. Methods associated with use of the energy delivery probe are also covered.

Abstract: Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure

Abstract: Device methods and systems for ablating a mucosal surface to treat patients with mucin hypersecretion is disclosed. An ablation device having a balloon membrane with a plurality of electrodes arranged on an external surface thereof is disclosed. The ablation device may be configured to ablate epithelial tissue of one or more target structures, such as the inner wall of a gallbladder. Each of the plurality of electrodes may be electrically coupled to a controller configured to selectively activate one or more of the plurality of electrodes at a time. The controller may activate less than all of the plurality of electrodes, thereby implementing a partial ablation procedure.

Abstract: A medical device comprising a cell including an ablation element and a carrier configured to receive at least a portion of said ablation element is disclosed. The medical device further comprises a tube enclosing the cell. At least a portion of the tube includes a membrane and the tube includes at least one hole proximate the ablation element for facilitating fluid flow. The medical device further comprises a fluid inlet for providing fluid to the interior of the tube. A method of using the medical device is also disclosed.

Abstract: A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer.

Abstract: In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

Abstract: The present disclosure provides a plasma system including an electrosurgical generator; an ionizable media source; and a plasma instrument. The plasma instrument includes a housing having a lumen defined therein terminating in an opening at a distal end thereof, the lumen being in fluid communication with an ionizable media source and a pair of electrodes coupled to the electrosurgical generator. The plasma system also includes a return electrode pad configured to couple to a patient; and a polarization controller electrically coupled to the return electrode, the polarization controller configured to adjust conductive coupling of the return electrode pad to the electrosurgical generator.

Abstract: A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.

Abstract: The invention provides a method and apparatus for monitoring a thermal effect of a conformal thermal treatment to diseased tissue in a target volume. The method includes acquiring a reference image of the volume containing the diseased tissue at a first position of the device, determining a baseline temperature distribution of the reference image, acquiring an image of the volume containing the diseased tissue while delivering a treatment to the volume, performing a phase subtraction between the image and the reference image to determine a change in phase between the image and the reference image and determining a current spatial temperature distribution in the volume containing the diseased tissue.

Abstract: The present disclosure relates to an electrosurgical apparatus to generate a dual plasma stream to perform electrosurgery on a surgical site on a patient. The apparatus and method of the present disclosure generates a hot gas jet to a surgical site by generating two plasma beams that are electrically up to 180 degrees out of phase from each other. Since each beam uses the other beam to establish plasma currents at a load, the combined dual plasma stream can be used on non-conductive surfaces, e.g., a tissue at the surgical site. Furthermore, by applying different flow rates to the plasma beams, various scanning effects by the hot gas jet can be achieved.

Abstract: Neuromodulation assemblies (200) include an extravascular prosthesis (202) disposed around and contacting at least a portion of an exterior surface (204) of a vessel (V) and a radially expandable intravascular prosthesis (206) contacting an interior surface (208) of the vessel. The neuromodulation assemblies are configured to compress, pinch, or squeeze a target nerve within the adventitia of the vessel between the extravascular and intravascular prostheses in order to impinge and disrupt the target nerve, thereby blocking or stopping nerve signal transduction. Neuromodulation assemblies configured in accordance with the present technology may also utilize radio-frequency energy, a drug, and/or magnetic attraction to block nerve signal transduction for neuromodulation thereof.

Abstract: In a first embodiment, a portable, battery-operated, minimally invasive small fiber neuropathy testing and diagnostic device, microcontrolled and interfacing with wireless powering to a wireless communications device is being disclosed. Said device is constructed out of an intra-epidermal thermal stimulus consisting of an electronically heated temperature-controlled polymer covered semiconductor material 101 lowered inside the skin through a probe 108 configured with three miniaturized electrodes 109 while a nerve impulse response measurement system records and identifies nerve action potential pulses through a proprietary algorithm. The invention also discloses a detection and characterization method of action potential pulses from neuron cells with respect to their timing such as pulse repetition statistics and rates from a single-point of measurement as diagnostically relevant for determining neuropathies.

Abstract: A device for circulating fluid to a target site within a living body, comprises a longitudinal member including an inlet lumen supplying fluid to the target site and a return lumen withdrawing fluid from the target site, the return lumen surrounding the inlet lumen and a screen coupled to a distal end of the longitudinal member, the screen including a plurality of openings extending therethrough from a radially inner surface forming a radially outer wall of a distal portion of the return lumen to an outer surface thereof.

Abstract: A high-power ultrasound heating applicator for minimally-invasive thermal treatment of uterine fibroids or myomas. High-intensity interstitial ultrasound, applied with minimally-invasive laparoscopic or hysteroscopic procedures, is used to effectively treat fibroids within the myometrium in lieu of major surgery. The applicators are configured with high-power capabilities and thermal penetration to treat large volumes of fibroid tissue (>70 cm3) in short treatment times (3-20 minutes), while maintaining three-dimensional control of energy delivery to thermally destroy the target volume.

Abstract: An apparatus and method are provided for spatially-selective administration of actions by at least one device in the body using a transducer that is sensitive to a spatially-variant energy field imposed on the at least one device by a source external to a subject's body; and at least one component in the at least one device, wherein interaction of the transducer with the imposed spatially-variant energy field causes or enables at least one component in the at least one device to affect nearby tissues in the body.

Abstract: Devices and methods for tissue ablation include injecting a conductive medium into a target tissue and then delivering an ablative agent to the conductive medium to ablate the target tissue. Optionally, the contents of the target tissue are removed using the ablation device prior to injection of the conductive medium. Positioning elements help maintain the device in the proper position with respect to the target tissue and also prevent the passage of ablative agent to normal tissues. Ablation catheters also include multiple inline chambers for the containing and heating of an ablative agent. The heating chambers include multiple channels to increase the contact surface area of the ablative agent with the walls of the heating chamber to provide more efficient heating. Induction heating is used to heat a chamber and vaporize a fluid within by wrapping a coil about a ferromagnetic chamber and providing an alternating current to the coil.

Abstract: A biomedical polymer composite that exhibits ultra-low thermal conductivity properties. In a preferred embodiment, the biomedical polymer composite comprises a base polymer component with a dispersed thermally non-conductive filler component consisting of glass or ceramic nanospheres or microspheres that have a thermal conductivity of less than 5 W/m-K, and preferably less than 2 W/m-K. In one embodiment, the polymer composite has an electrically conductive filler and can be used in a filament for treating arteriovascular malformations. In another embodiment, the polymeric composite can be used as an energy-coupling means to apply energy to tissue.

Abstract: Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart. In one embodiment, an ablation catheter system includes a handle and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a distal end thereof. The ablation catheter system may also include an electrode coupled to the handle with lines extending through the lumen of the catheter, the electrode being configured to be constrained adjacent the distal end of the catheter and configured to be deployed from the distal end of the catheter to an expanded configuration.

Abstract: Devices, systems and methods are provided for deployment of one or more functional devices, such as therapeutic and/or diagnostic medical devices and/or positioning devices, at various locations relative to a defined operative path. The devices, systems, and methods can include a guide system and a positioning element. The guide system defines the operative path when deployed within a patient's body. The positioning element cooperates with the guide system to define one or more positions relative the defined operative path from which the one or more functional devices are deployed. The present inventions allow for the accurate and reliable placement of the one or more functional devices at the one or more positions relative the operative path. In one embodiment, the functional device is an ablation device adapted to ablate cardiac tissue for the treatment of cardiac arrhythmias, such as atrial fibrillation.

Abstract: A system for controlling temperature of a fluid used during treatment of biological tissue includes a fluid temperature control apparatus. The apparatus includes at least one heat transfer device and a solution bag and/or a heat transfer membrane. The solution bag and/or the heat transfer membrane reside in thermal communication with the heat transfer device. When the solution bag and/or the heat transfer membrane is fluidically coupled to an electrosurgical device, fluid is supplied to the electrosurgical device at a controlled temperature during a surgical procedure utilizing the electrosurgical device to enable more efficient treatment of the biological tissue. A corresponding method includes fluidically coupling the fluid temperature control apparatus to the electrosurgical device and supplying fluid at a controlled temperature during a surgical procedure utilizing the electrosurgical device to enable more efficient treatment of the biological tissue.

Abstract: Methods for manipulating and/or reinforcing tissues are provided. The method includes applying a tissue reinforcement material to at least a portion of tissue to be manipulated and applying energy to one or both of the tissue reinforcement material and the tissue.

Abstract: An apparatus for determining a thermal property of tissue includes a base unit with one or more energy source and at least two, preferably detachable, leads. The distal end of each lead, which is introduced into the tissue to be treated, has at least two longitudinally spaced temperature measuring elements to measure surrounding tissue temperature and at least two longitudinally spaced electrode surfaces for applying current to the tissue. Each distal end is also provided with an element which uses energy emitted by the sources of energy to heat up the surrounding tissue. The base unit has computing elements, current generating elements for generating an alternating current, and conductance determining elements for determining the tissue conductance between pairs of electrode surfaces based on the alternating current applied by the current generating elements to the tissue. Methods for using the device and leads for use in the device are also described.

Abstract: An ultrasound apparatus is provided for non-continuous circumferential treatment of a vessel, such to provide denervation of a renal blood vessel. The apparatus may be positioned within a vessel to deliver broad unfocused or focused ultrasonic energy at first and second lengthwise and angular positions to create a less-than-full circumferential treatment zone at each of the first and second positions. Superimposition of treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion.

Abstract: A method of removing at least one hair from a mammal comprising the steps of associating electromagnetic responsive species to the root of at least one hair and exposing the electromagnetic responsive species to an oscillating electromagnetic field.

Abstract: This relates to treating airways in a lung to decrease asthmatic symptoms. The also includes steps of measuring a parameter of an airway at a plurality of locations in a lung, identifying at least one treatment site from at least one of the plurality of locations based on the parameter, and applying energy to the treatment site to reduce the ability of the site to narrow.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: A catheter-based medical device includes a catheter that is configured and arranged for at least partial insertion into a patient and that defines at least one lumen that is configured and arranged to receive a first fluid. A conductive-fluid detector is coupled to the at least one lumen and is configured and arranged to detect when a second fluid is disposed within the at least one lumen that is more conductive than the first fluid. The conductive-fluid detector includes a plurality of axially-positioned bodies, each body defining a lumen. The lumens of the axially-positioned bodies are aligned to form a shared lumen in fluid communication with the at least one lumen of the catheter. Spaced apart electrodes are disposed within the shared lumen.

Abstract: A device for treating tissue adjacent to a body lumen includes a catheter shaft and an energy emitting assembly. The catheter shaft is insertable into the body lumen and includes a plurality of cooling lumens arranged generally circumjacent a generally central lumen. At least some of the circumjacent cooling lumens are in fluid communication with the central lumen and the energy emitting assembly extends through the central lumen. The central lumen and at least one portion of the energy emitting assembly are configured to direct a flow of cooling fluid about an outer surface of the at least one portion of the energy emitting assembly within the central lumen.

Abstract: An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Abstract: A cardiac ablation device, including a steerable catheter (10) and an expandable ablation element (18) incorporating one or more balloons (20,22) at the distal end of the catheter, has a continuous passageway (28, 30) extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. A probe (72) carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop (82) which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the sensor probe.

Abstract: A therapeutic apparatus comprising a high intensity focused ultrasound system (302) for sonicating a sonication volume (324) of a subject (320). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (350) within an imaging volume (316). The sonication volume is within the imaging volume. The therapeutic apparatus further comprises a controller (304) for controlling the therapeutic apparatus. The treatment plan comprises instructions for controlling the operation of the high intensity focused ultrasound system. The controller is adapted for sonicating (100) the target volume using the high intensity focused ultrasound system. The controller is adapted for repeatedly acquiring (102) magnetic resonance thermometry data using the magnetic resonance imaging system during execution of the treatment plan.

Abstract: A system for transmitting electrosurgical energy from a generator to an electrosurgical instrument for electro-thermal ablation is disclosed. The generator includes one or more active output terminals which supply energy to tissue and are operatively connected to one or more supply lines. The generator also includes one or more return output terminals which return energy from the tissue and are operatively connected to one or more return lines. The system also includes an electrosurgical cable housing a portion of the one or more supply lines and one or more return lines. The electrosurgical instrument includes a helical electro-thermal element operatively connected to the one or more supply lines and the one or more return lines. The one or more supply lines and one or more return lines are wound in a double helix arrangement such that the electrical field along the cable and helical electro-thermal element is mitigated along the lengths thereof.

Abstract: A surgical instrument comprising a surgical instrument with opposing jaw members for clamping tissue therebetween. The surgical instrument may comprise a latch at a distal end of the end effector. The latch latches the distal end of the first jaw member to the distal end of the second jaw when the jaw members are in the closed position. Also, one of the jaw members may comprise a moveable tissue-contacting portion and a thermally-controlled spring adjacent to the tissue-contacting portion. The thermally-controlled spring is transitionable between a contracted state and an expanded state. The thermally-controlled spring may comprise a temperature-dependent, two-way memory effect, shape memory material. In the expanded state, the thermally-controlled spring urges the moveable tissue-contacting portion in a direction toward the other jaw member when the jaw members are in the closed position.

Abstract: One embodiment comprises an apparatus for applying energy to a hollow anatomical structure having an inner wall. The apparatus comprises an elongate shaft having a distal end and a proximal end opposite the distal end; and a capacitive treatment element located near the distal end. The capacitive treatment element is sized for insertion into the hollow anatomical structure and placement near the inner wall. The capacitive treatment element is configured to create an electric field that extends at least partially into the inner wall. Other devices and methods for treatment of hollow anatomical structures are disclosed as well.

Abstract: An ultrasonic clamp coagulator assembly that is configured to permit selective cutting, coagulation and clamping of tissue during surgical procedures. An elongated portion of the instrument can be configured for endoscopic applications and has an outside diameter of less than 6 mm. The construction includes a clamping mechanism, including a clamp arm pivotally mounted at the distal portion of the instrument, which is specifically configured to create a desired level of tissue clamping forces, exceeding 4 pounds when the trigger is fully closed. The clamping mechanism includes a two-piece pad design and pad material that enables the higher tissue clamping forces and a force-limiting mechanism that effectively smooths out abusive tissue forces. The assembly also features hand activation configured to provide an ergonomical grip and operation for the surgeon. Hand switches are placed in the range of the natural swing of the surgeon's thumb, whether gripping the surgical instrument right-handed or left handed.

Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.