Abstract: An electro-surgical pencil comprising: a housing forming an axially extending main suction passage from a proximal opening to a distal opening; a tube forming an extension of the main suction passage from the proximal opening to a proximal extension opening, the tube being configured for telescoping movement through the proximal opening; an electrode for cutting and/or coagulating tissue, the electrode being attached to the tube and extending axially from the proximal extension opening; and a suction tip attached to the tube and forming a further extension of the suction passage. Since both the tube and the suction tip are movable relative to the housing, a short and a long configuration can be obtained while good smoke removal capabilities are maintained.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient and including a plurality of electrodes configured to contact tissue within the body. An electrical signal generator applies bipolar trains of pulses having a voltage amplitude of at least 200 V and having a duration of each of the bipolar pulses less than 20 ?s between at least one pair of the electrodes in contact with the tissue, thereby causing irreversible electroporation of the tissue between the at least one pair of the electrodes. One or more electrical sensors sense an energy dissipated between the at least one pair of the electrodes during the trains of the pulses. A controller controls electrical and temporal parameters of the trains of the pulses applied by the electrical signal generator, responsively to the one or more electrical sensors, so that the dissipated energy satisfies a predefined criterion.

Abstract: Electrode assemblies include segmented electrodes disposed on a catheter. The segmented electrodes can be constructed at the tip of the catheter or more proximally located. Tip electrodes can be constructed from an electrically-insulative substrate covered with a conductive material. The conductive material can be deposited on the electrically-insulative substrate to form a single tip electrode or multiple segmented electrodes. In some embodiments the tip electrode can include irrigation flow holes for irrigation. A method of manufacturing a tip electrode comprising a thin layer of conductive material deposited on an electrically-insulative substrate is disclosed. Segmented ring electrodes can be constructed from segmented ring electrodes that can be equally separated around a circumference of a catheter. The segmented ring electrodes can be formed into segmented electrode subassemblies that can then be joined to a catheter shaft.

Abstract: Control systems and methods for delivery of energy that may include control algorithms that prevent energy delivery if a fault is detected and may provide energy delivery to produce a substantially constant temperature at a delivery site. In some embodiments, the control systems and methods may be used to control the delivery of energy, such as radiofrequency energy, to body tissue, such as lung tissue.

Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.

Abstract: Electrosurgical systems and methods are provided for RF nerve ablation, wherein a control console is utilized with a passive or active cable accessory connecting to different of electrode attachments, such as monopolar and bipolar self-grounding types. The control console has multiple RF amplifiers that are associated with multiple channels of the control console and that are energized according to control signals non-simultaneously applied by a controller of the control console. The control console stores and processes identification data and usage data relating to cable accessories and electrode attachments that are connected or have been connected to the control console over time. The control console displays a representation of this processed data on a graphical user interface.

Abstract: A catheter has a two-piece tip electrode with a shell and a support structure defining a chamber, and a fluid distribution tube that extends longitudinally into the chamber, the fluid tube having fluid apertures along its length for distributing fluid more uniformly distributed throughout the chamber for improved cooling and thus minimizing the risk of char formation on regions of the tip electrode more prone to overheating.

Abstract: A method that includes selectively positioning an ablation catheter system at a treatment site; and ablating tissue at the treatment site with the ablation catheter system using a power setting of approximately 90 W applied to tissue for approximately four (4) second increments with a break period of approximately 4 seconds between applications.

Abstract: The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.

Abstract: A catheter has a cooling distal section for freezing tissue to sub-zero temperatures with one or more miniature reverse thermoelectric or Peltier elements, also referred to herein as micro-Peltier cooling (MPC) units or electrodes. The MPC units may be on outer surface of an inflatable or balloon member or a tip electrode shell wall that has a fluid-containing interior cavity acting as a heat sink. Each MPC unit has a hot junction and a cold junction whose temperatures are regulated by the heat sink, and a voltage/current applied to the MPC units. A temperature differential of about 70 degrees Celsius may be achieved between the hot and cold junctions for extreme cooling, especially where the MPC units include semiconductor materials with high Peltier co-efficients. An outer coating of thermally-conductive but electrically-insulative material seals the MPC units to prevent unintended current paths through the MPC units.

Abstract: A surgical system includes a fluid source including a fluid inflow tube, a fluid delivery device coupled to the fluid inflow tube and configured to deliver fluid from the fluid source into a patient, a surgical instrument, and a control box coupled to the surgical instrument. The control box includes one or more waste heat-generating electronic components and a heat pipe assembly disposed in thermal communication with the one or more waste heat-generating electronic components. The fluid inflow tube is disposed in thermal communication with the heat pipe assembly of the control box such that the heat pipe assembly conducts heat away from the one or more waste heat-generating electronic components and heats fluid flowing through the fluid inflow tube.

Abstract: An electrosurgical instrument is disclosed including a pencil-grip handle, a shaft coupled to the pencil-grip handle, and an end effector coupled to the shaft. The end effector includes a body, a source electrode, and one or more return electrodes. The source electrode and the one or more return electrodes are configured to provide a multi-phase bipolar electrosurgical signal to tissue. The one or more return electrodes each comprise a first return electrode and a second return electrode. The electrosurgical instrument further includes an electrosurgical generator coupled to the end effector. The electrosurgical generator is configured to produce the multi-phase bipolar electrosurgical signal including a first phase, a second phase, and a third phase. The electrosurgical generator is coupled to the source electrode, the first return electrode, and the second return electrode. The first phase, the second phase, and the third phase are combined to generate the multi-phase bipolar electrosurgical signal.

Abstract: Surgical devices, systems and methods for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device comprises a handle (20a) having a proximal end and a distal end; a shaft extending distally beyond the distal end of the handle, the shaft having a proximal end and a distal end; an electrode tip (45), at least a portion of the electrode tip extending distally beyond the distal end of the shaft, the electrode tip extending distally beyond the distal end of the shaft comprising a spherical end surface portion (25) and a cylindrical side surface portion, the spherical end surface portion located distal to the cylindrical side surface portion and comprising at least a portion of the distal end surface of the surgical device; and a fluid passage directed to provide a fluid towards the cylindrical side portion of the electrode tip.

Abstract: A device for delivering a composition to a hollow body region is disclosed. In one aspect, the device comprises a first longitudinal member and a second longitudinal member. Both of the longitudinal members may comprise conductive electrodes. The longitudinal members are further configured to be connected to an energy source such that the conductive electrodes are configured to generate an energy field. At least one of the longitudinal members further comprises a delivery element configured to deliver at least one composition to the body region, such that the composition is delivered in a direction that is influenced by the generated energy field. In one aspect, the body region is a vessel comprising an occlusion.

Abstract: An implant including first and second end plates, each of which defines at least one anterior ramped surface and at least one posterior ramped surface. A posterior actuator is positioned between the first and second end plates and has guiding ramp surfaces which correspond with the posterior ramped surfaces. An anterior actuator is positioned between the first and second end plates and guiding ramp surfaces which correspond with the anterior ramped surfaces. An actuator assembly extends between the posterior actuator and the anterior actuator and is configured to selectively move the posterior actuator and the anterior actuator simultaneously, move posterior actuator independently of the anterior actuator, or move the anterior actuator independently of the posterior actuator.

Abstract: An implant including first and second end plates, each of which defines at least one anterior ramped surface and at least one posterior ramped surface. A posterior actuator is positioned between the first and second end plates and has guiding ramp surfaces which correspond with the posterior ramped surfaces. An anterior actuator is positioned between the first and second end plates and guiding ramp surfaces which correspond with the anterior ramped surfaces. An actuator assembly extends between the posterior actuator and the anterior actuator and is configured to selectively move the posterior actuator and the anterior actuator simultaneously, move posterior actuator independently of the anterior actuator, or move the anterior actuator independently of the posterior actuator.

Abstract: An ablation electrode is mounted on the distal end of a catheter with a first portion inside and a second portion outside the catheter. The second portion is adapted to have a surface that makes maximum contact with a tissue to be ablated, leaving a minimum area not covered by the tissue and potentially exposed to blood. The first portion is adapted to provide an extended surface area for efficient exchange of heat with a coolant flowing inside the catheter. Outlets provided near the area not covered by the tissue in the second portion prevents blood from getting close to or come directly in contact with the area, thereby greatly reducing formation of dangerous blood clots. The minimizing of an electrical circuit through blood greatly reduces wasted power into the electrode so that the efficiently cooled electrode is not burdened. The catheter preferably has multiple electrodes with similar features.

Abstract: An ablation electrode is mounted on the distal end of a catheter with a first portion inside and a second portion outside the catheter. The second portion is adapted to have a surface that makes maximum contact with a tissue to be ablated, leaving a minimum area not covered by the tissue and potentially exposed to blood. The first portion is adapted to provide an extended surface area for efficient exchange of heat with a coolant flowing inside the catheter. Outlets provided near the area not covered by the tissue in the second portion prevents blood from getting close to or come directly in contact with the area, thereby greatly reducing formation of dangerous blood clots. The minimizing of an electrical circuit through blood greatly reduces wasted power into the electrode so that the efficiently cooled electrode is not burdened. The catheter preferably has multiple electrodes with similar features.

Abstract: A spacer for separating bones of a joint, the spacer includes a first endplate configured to engage a first bone of the joint; a second endplate configured to engage a second bone of the joint; tissue engaging projections, wherein the tissue engaging projections are moveable from a retracted position to a deployed position; and an actuation subassembly that extends between the first endplate and the second endplate, wherein the actuation subassembly comprise a drive nut, a drive screw coupled to the drive nut, and a cam frame coupled to the drive screw, wherein the cam frame is disposed between the first endplate and the second endplate to engage the tissue engaging projections.

Abstract: An extendable electrosurgical pencil adapted to receive an electrode controllable by an electrical signal for performing surgical operations, including a housing that comprises first and second housing parts with a main housing part therebetween, a flexible printed circuit, a switch on the main housing part that is adapted to be activated from outside the housing for closing the flexible circuit, and an electrode receiver on the first housing part, wherein the first housing part is adapted to slide inside the main housing part to provide a telescopic extension of the pencil, the electrode and the flexible printed circuit following the sliding movement.

Abstract: An implant including a housing having a peripheral frame including an inner edge defining central opening in a central portion of the implant. The implant may also include a blade located within the central opening, the blade having a retracted position in the housing and an extended position where the blade extends outwardly from the housing. In addition, the implant may include a blade actuating component comprising a driven shaft portion and a blade engaging portion. The blade actuating component may be configured to be translated to move the blade between the retracted position and the extended position. Also, the inner edge of the peripheral frame may include a posterior edge configured to support the blade in two locations.

Abstract: A heating system includes a power supply module, a regulatory module, electrically connected to the power supply module, for modulating the power supply module, and a heating module. The heating module includes a positioning device and a conductive device. The heating module is electrically connected to the power supply module and the regulatory module, and the conductive device is tightly wound around the positioning device.

Abstract: A living tissue bonding system includes a treatment instrument having a heating element which applies thermal energy to living tissue, an element temperature measuring section configured to measure an element temperature T1 of the heating element, a power source configured to generate power, a first calculating section configured to estimate a temperature difference ?T between the element temperature T1 and a temperature T2 of the living tissue using a table or an equation stored beforehand in order to estimate the temperature difference ?T based on an output value of the power source, a second calculating section configured to estimate the tissue temperature T2 from the element temperature T1 and the temperature difference ?T estimated by the first calculating section, and a control section configured to control the power source based on the tissue temperature T2 estimated by the second calculating section.

Abstract: A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.

Abstract: A method, including selecting a first maximum radiofrequency (RF) power to be delivered by an electrode within a range of 70 W-100 W, and selecting a second maximum RF power to be delivered by the electrode within a range of 20 W-60 W. The method also includes selecting an allowable force on the electrode within a range of 5 g-50 g, selecting a maximum allowable temperature, of tissue to be ablated, within a range of 55° C.-65° C., and selecting an irrigation rate for providing irrigation fluid to the electrode within a range of 8-45 ml/min. The method further includes performing an ablation of tissue using the selected values by initially using the first power, switching to the second power after a predefined time between 3 s and 6 s, and terminating the ablation after a total time for the ablation between 10 s and 20 s.

Abstract: An electrophysiologic catheter with an improved control handle is provided. The catheter includes a heat transfer assembly to better dissipate heat in the control handle. The heat transfer assembly includes a pump, a reservoir containing a coolant, a heat transfer member, and a coolant transport network transporting coolant between at least the reservoir and the heat transfer member. In one embodiment, the heat transfer member is located within the control handle as a heat exchanger on the circuit board to receive the coolant for transferring heat from the integrated circuits to the coolant. In another embodiment, the heat transfer member is located on the circuit board directly surrounding the integrated circuits to internally cool the integrated circuit within the control handle. A second heat transfer member is located outside of the control handle as a heat exchanger.

Abstract: A method for use with an intra-body probe, a distal end of which includes an ablation electrode and a temperature sensor, is described. While (i) the ablation electrode is driving an ablating current into tissue of a subject, and (ii) fluid is passed from the distal end of the intra-body probe at a fluid-flow rate, a processor receives a temperature sensed by the temperature sensor. The processor estimates a temperature of the tissue, based at least on the sensed temperature and at least one parameter selected from the group consisting of: the fluid-flow rate, and a parameter of the ablating current. The processor generates an output in response to the estimated temperature. Other embodiments are also described.

Abstract: The disclosed subject matter relates a medical instrument having a rotational drive mechanism that can be integrated into a variety of medical devices, including a tool used as an external retaining ring removal tool or as a non-marring bushing inserter, or in a spinal interbody device. The tool can include a knob portion at a proximal end and a drive mechanism at the distal end. The drive mechanism can include a plurality of drive pins that can be actuated to extend outward by rotating the knob portion. The spinal interbody device can include a drive mechanism configured to translate rotational motion into a linear driving motion to cause locking projections to move into engagement with vertebrae.

Abstract: An RF electrode can have a straight shaft to generate an RF heat lesion that is asymmetric about the central axis of the cannula through which the RF electrode is introduced into bodily tissue. An electrode can be inserted into a cannula, and an electrosurgical generator can apply current between the active tip of the electrode and the active tip of the cannula to heat tissue.

Abstract: An RF electrode can have a straight shaft to generate an RF heat lesion that is asymmetric about the central axis of the cannula through which the RF electrode is introduced into bodily tissue. For example, a system for tissue ablation can include a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically conductive active tip distal to an electrically insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion of the cannula shaft, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically conductive active tip distal to an electrically insulated electrode shaft portion.

Abstract: An expandable intervertebral implant is provided for insertion into an intervertebral space defined by adjacent vertebrae. The expandable intervertebral implant includes a pair of outer sleeve portions and an inner core disposed between the outer sleeve portions. Movement of the inner core relative to the outer sleeve portions causes the outers sleeve portions to deflect away from each other, thereby engaging the expandable intervertebral implant with the vertebrae and adjusting the height of the intervertebral space.

Abstract: A method, system and apparatus are disclosed for performing an electrosurgical treatment procedure on a bodily tissue. An electrosurgical apparatus is described, the apparatus comprising one or more probes having insulated and conductive regions for creating lesions in bodily tissue. A method of delivering energy to a patient's body is described, including methods of treating sacro-iliac related pain using electrosurgical probes.

Abstract: A skin treatment device for home use is provided herein. The device has enhanced safety features and improved operation efficiency. RF energy is delivered under strict control to a relatively small and well localized volume of the skin, avoiding excessive heating of the skin surface. Surface heating is monitored both by direct temperature measurement and by movement monitoring of the device to ensure proper use and prevent skin overheating and the pain associated therewith.

Abstract: An expandable vertebral body replacement is presented. The device has an inner and outer housing longitudinally moveable on one-another which locks in place using a retention member. This can be locked or fortified by several described options. Also presented is a method for expanding said device embodiments and a system for an expandable vertebral body replacement.

Abstract: Surgical cutting apparatus having a treatment channel and a measurement channel for conveying microwave energy from a source to an antenna at a cutting edge. The measurement channel operates at lower power than the treatment channel for determining when higher energy can be safely applied. The apparatus may deliver microwave radiation at differing frequencies to one or more antennas at the cutting edge, e.g. to provide different treatment effects. The source may generate an output for an antenna whose frequency can be selected e.g. for most efficient operation. Selection may be automatic based on detected magnitude and phase of reflected signals during a frequency sweep of a forward signal. Power delivered to tissue via the cutting element may be manually boosted to deal with large blood vessels. The apparatus may include a reflected power monitor for recognizing behavior in reflected signals received from the antenna to trigger automatic pre-emptive action.

Abstract: A polyphase electrosurgical system and method are provided. In embodiments, a radiofrequency generator having the capability of delivering a plurality of independent electrosurgical signals is disclosed. An electrosurgical instrument having an array of electrodes that correspond to the plurality of signals may be used to deliver the electrosurgical signals to tissue. In embodiments, three RF signals having a phase offset of about 120° therebetween, i.e., a three-phase configuration, may be used to achieve a balanced delivery of electrosurgical energy, which may lead to increased rates of energy delivery, improved control of tissue ablation regions, and improved operative outcomes. The phase, amplitude, and/or frequency of each signal may be independently variable in response to user inputs and/or biological parameters such as tissue impedance or return electrode current.

Abstract: A method of performing therapy on tissue using a medical apparatus. The apparatus includes a shaft configured for insertion into a hollow anatomical structure (HAS) and has a tissue sensor and a therapeutic energy application device both located on the shaft. The method comprises: receiving electrical power at a first power level and directing the first-level power to the tissue sensor and not to the therapeutic energy application device, thereby enabling tissue sensing with the tissue sensor; receiving electrical power at a second power level higher than the first-level power; and, in response to receipt of the second-level power, directing the second-level power to the therapeutic energy application device, thereby enabling performance of therapy on the tissue with the therapeutic energy application device. Additional methods and apparatus are disclosed as well.

Abstract: The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.

Abstract: A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue.

Abstract: Intrauterine devices and methods for facilitating deployment thereof using a bumper are disclosed. In one embodiment, an intrauterine device comprises a structure including a first central support member and a deployment mechanism coupled to the first central support member. The intrauterine device further comprises a bumper positioned at a distal end of a second central support member and at a more distal position relative to a distal end of the structure so as to prevent the distal end of the structure from contacting the fundus of the uterus of a patient during deployment of the deployment mechanism. In another embodiment, the intrauterine device comprises a bumper coupled to the deployment mechanism and configured to move from a more distal to a more proximal position relative to a distal end of the structure.

Abstract: A power source delivers oscillating electrical energy to an electrical conductor, such as a wire or catheter, which is coated circumferentially with a ferromagnetic material in a selected region. With high frequency electrical energy, the ferromagnetic material has a quick response in heating and cooling adjustable by the controllable power delivery. The ferromagnetic material can be used for separating tissue, coagulation, tissue destruction or achieving other desired tissue effects in numerous surgical procedures.

Abstract: Thermal, Electrosurgical and Mechanical modalities may be combined in a surgical tool. Potentially damaging effects in a first modality may be minimized by using a secondary modality. In one example, thermal hemostasis may thus help electrosurgical applications avoid the adverse tissue effects associated with hemostatic monopolar electrosurgical waveforms while retaining the benefits of using incising waveforms.

Abstract: A medical heating device is based on an electrical heater formed out of a self-limiting conductive material, such as a conductive polymer or ceramic. An electrical resistance that gradually changes with temperature characterizes the material such that heat production from electrical current through the material varies with temperature. A thermally insulating jacket contains the self-limiting heater element, which can be coupled to an electrical power supply. A probe thermally coupled to the heater extends outward from the jacket. The self-limiting medical heating device can be used by touching the end of the probe to target tissue, such as skin, adipose tissue, nerves, glands, vascular tissue, or abnormal growths or tumors to effect the desired treatment, typically by thermally ablating, cutting, or shrinking the target tissue where touched by the probe or in the vicinity therein.

Abstract: A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.

Abstract: A apparatus for performing tissue modification procedures on a patient's body can include a device, which can be adapted for connection to at least two electrodes, where temperature sensors can be incorporated into tip portions of said electrodes, a high frequency generator, which can be operatively associated with said device, wherein said generator can deliver non-simultaneously a high frequency signal output to each of said electrodes, and a feedback control circuit, which can be configured to regulate the signal output delivery to each of said electrodes so it can maintain a user settable temperature at tip portion of said electrodes when the electrodes can be in contact with the patient's body.

Abstract: A microwave apparatus comprises a microwave source for providing a microwave signal, connectable to a load; control means configured in operation to vary over a frequency range a frequency of the microwave signal provided by the source; a microwave detector for performing microwave measurements, arranged to receive reflections from and/or transmissions to the load in operation and to perform a plurality of measurements, each measurement corresponding to a respective one of a plurality of different frequencies of the frequency range; and means for determining from the plurality of measurements a measure of reflection and/or a measure of transmission.

Abstract: A cooling system for a surgical handpiece may provide fluid flow to the surgical tip and to the internal electronic components to prevent temperatures that may damage or make the patient or surgeon uncomfortable. Tip directed gas further controls the tip-tissue interface by displacing blood or serum from the incision point, increasing precision and diminishing coagulum build-up. In the alternative, cooling fluid may be used to quench tissue being treated.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: A device and a method for shrinkage of tissue containing collagen is described. The device comprises a heating tip, a support shaft, and a control system. The heating tip comprises a heating element and a temperature sensor therein. The control system is configured to receive a temperature feedback from the temperature sensor and to regulate energy delivered to the heating element based on the temperature feedback. Heating of the tissue region causes shrinkage of collagen-containing tissue, thereby closing any perforation or opening in the tissue region.

Abstract: A system and method are described for sensing the orientation of a catheter relative to a tissue and regulating the application of power to maintain the tissue at a pre-determined temperature.