Applicator Placed Around Stimulated Nerve Patents (Class 607/118)
  • Patent number: 10981007
    Abstract: Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: April 20, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Yogi Anil Patel, Ravi V. Bellamkonda, Robert Butera, Tarun Saxena
  • Patent number: 10981000
    Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: April 20, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, William Dai
  • Patent number: 10952806
    Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: March 23, 2021
    Assignee: AXOGEN CORPORATION
    Inventors: Curt Deister, Crystal Simon, Jennifer Faleris
  • Patent number: 10946189
    Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: March 16, 2021
    Assignee: Galvani Bioelectronics Limited
    Inventors: Faisal Zaidi, Sabastien Ouchouche, Paul Matteucci, Jr.
  • Patent number: 10945805
    Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: March 16, 2021
    Assignee: AXOGEN CORPORATION
    Inventors: Curt Deister, Crystal Simon, Jennifer Faleris
  • Patent number: 10926084
    Abstract: Some implementations provide a method for modulating excitable tissue in a body of a patient, the method including: placing a wireless implantable stimulator device at a target site in the patient's body, the stimulator device including one or more electrodes; reconfiguring the wireless implantable stimulator device to form an enclosure that substantially surrounds the excitable tissue at the target site with the electrodes on the inside of the enclosure and facing the nerve; and causing electrical impulses to be delivered to the electrodes on the wireless implantable stimulator device such that neural modulation is applied to the excitable tissue substantially surrounded by the enclosure.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 23, 2021
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Patrick Larson, Chad Andresen
  • Patent number: 10898718
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second sensor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: January 26, 2021
    Assignee: Boston Scientific Neuromoduiation Corporation
    Inventors: Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, Dat Thanh Huynh, Bryan Allen Clark, Jianwen Gu
  • Patent number: 10898092
    Abstract: An implantable cuff electrode having a flexible cuff in form of a tube having a longitudinal slot, wherein the longitudinal slot defines a first edge and a second edge on the cuff, wherein a first lip is arranged at the first edge of the longitudinal slot, and a second lip is arranged at the second edge of the longitudinal slot, and wherein the longitudinal slot can be sealed by the first lip and the second lip in that the first lip and the second lip extend at least partially on the cuff jacket of the cuff one lying on top of the other, and the second lip holds the first lip in position by means of a surface pressure onto the cuff jacket.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: January 26, 2021
    Assignee: CorTec GmbH
    Inventors: Martin Schüttler, Juan Sebastian Ordonez, Jörn Rickert, Thomas Stieglitz
  • Patent number: 10864369
    Abstract: The disclosure relates to implantable probes. An implantable probe includes a sleeve capable of being wound around an elongate organ of cylindrical shape, and includes a sheet of elastically deformable material that supports at least one electrode. The sheet is prestressed in such a way as to allow it to self-wind from an initial position, in which the sheet is kept stressed in the deployed state, to a final position, in which the sheet is wound freely in a spiral to form a sleeve around the organ, with the first face, which supports the electrodes, being directed towards the inside. The sheet is delimited by an outer lateral edge of the sleeve after winding, an inner lateral edge of the sleeve after winding, and a first transverse edge and a second, opposite transverse edge. The sheet includes perforations located in proximity to the first and/or second transverse edge.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: December 15, 2020
    Assignee: Sorin CRM SAS
    Inventors: Hervé Mevel, Stéphane Befahy, Vincent Callegari
  • Patent number: 10842996
    Abstract: A device for neurostimulation including an electrode structure for delivering stimulation pulses to a nerve as well as for processing and extracting evoked compound action potentials, wherein the electrode structure comprises at least a first anode, at least a second anode opposing the first anode and a plurality of cathodes arranged between said anodes, wherein said cathodes are asymmetrically arranged with respect to said at least first and second anode to permit evoked compound action potential sensing via the anode electrodes simultaneously with stimulation.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: November 24, 2020
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Marcelo Baru, Andrew B. Kibler
  • Patent number: 10758723
    Abstract: A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 1, 2020
    Assignee: Neuros Medical, Inc.
    Inventors: Zi-Ping Fang, Nemath Syed Shah
  • Patent number: 10751525
    Abstract: Conductors within an implantable medical lead that carry stimulation signal signals are at least partially embedded within a lead body of the medical lead over at least a portion of the length of the conductors while being surrounded by a radio frequency (RF) shield. A space between the shield and the conductors is filled by the presence of the lead body material such that body fluids that infiltrate the lead over time cannot pool in the space between the shield and the conductors. The dielectric properties of the lead body are retained and the capacitive coupling between the shield and the conductors continues to be inhibited such that current induced on the shield is inhibited from being channeled onto the conductors. Heating at the electrodes of the medical lead is prevented from becoming excessive.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: August 25, 2020
    Assignee: MEDTRONIC, INC.
    Inventors: Jamu K. Alford, Spencer Fodness Bondhus, Michael Kalm, James M. Olsen, Brian T. Stolz, Richard T. Stone, Bryan D. Stem, John D. Welter
  • Patent number: 10744326
    Abstract: Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: August 18, 2020
    Assignee: Medtronic, Inc.
    Inventors: Gary W. King, Steven M. Goetz, Andrew H. Houchins, Jeffrey T. Keacher, Jordan J. Greenberg, Kenneth T. Heruth, Mark S. Lent, Paul W. Wacnik
  • Patent number: 10660535
    Abstract: Devices, systems, and methods for recording action potential (AP) from a nerve are provided. A device can include a cuff or a microchannel to be used to record an AP from a nerve. A recording electrode can be included within a channel of the cuff or microchannel, and the recording electrode can be offset or off-center such that it is not located mid-channel within the recording cuff or microchannel.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: May 26, 2020
    Assignee: The Florida International University Board of Trustees
    Inventors: Iian Black, James Abbas, Ranu Jung
  • Patent number: 10632308
    Abstract: A method including chronically implanting a nerve cuff electrode on a portion of a hypoglossal nerve, chronically implanting a respiration sensing lead subcutaneously in a thorax of a patient, the respiration sensing lead having a plurality of bio-impedance electrodes defining at least one bio-impedance vector. The method may also include sensing a bio-impedance signal corresponding to respiration via a bio-impedance vector on an anterior side of the thorax, analyzing the bio-impedance signal to identify onsets of expiration, predicting an onset of a future expiratory phase, and delivering a stimulus to the portion of the hypoglossal nerve via the nerve cuff electrode, wherein the stimulus is delivered as a function of the bio-impedance signal; wherein stimulus delivery is initiated before the onset of the future expiratory phase and continued during an entire inspiratory phase, and wherein the method is performed without identifying an onset of an inspiratory phase.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 28, 2020
    Assignee: LivaNova USA, Inc.
    Inventors: Stephen L. Bolea, Thomas B. Hoegh, Bruce J. Persson, Robert E. Atkinson, Scott T. Mazar
  • Patent number: 10603504
    Abstract: Methods and devices are disclosed for inducing analgesia in a localized region of tissue. Inducing analgesia may be performed by identifying a nerve associated with the localized region, determining a resonant frequency for target neuronal cell membranes of the nerve, and generating a peripheral nerve blockade using the determined resonant frequency. The resonant frequency may be a frequency at which impedance of the nerve approaches a maximum.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: March 31, 2020
    Assignee: Alacrity, Inc.
    Inventors: Philip C. Cory, Steven P. Woodard
  • Patent number: 10596367
    Abstract: A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 24, 2020
    Assignee: SetPoint Medical Corporation
    Inventors: Michael A. Faltys, Jacob A. Levine, Jesse M. Simon
  • Patent number: 10525259
    Abstract: A vestibular electrode is described that is for implantation into a vestibular semi-circular canal. An intra-labyrinthine electrode carrier with a C-shaped cross-section has an inner concave surface and an outer convex surface, and is configured to fit through an electrode opening in an outer surface of the bony labyrinth into the perilymph fluid without breaking the membranous labyrinth so as to fit the inner concave surface of the electrode carrier adjacent to the membranous labyrinth and the outer convex surface adjacent to the bony labyrinth. There are one or more electrode contacts on a surface of the electrode carrier that are configured for electrical interaction with adjacent neural tissue.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: January 7, 2020
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventors: Andreas Marx, Angelo De Marzo, Rami Saba
  • Patent number: 10493297
    Abstract: An implantable optical electrode having a thin film electrode array including a plurality of electrodes, a light source associated with the thin film electrode array, and a passive bioactive agent delivery module associated with the thin film electrode array. Also disclosed are methods of manufacturing the array and a neural interface system with passive fluid delivery.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: December 3, 2019
    Assignee: NeuroNexus Technologies, Inc.
    Inventors: John P. Seymour, KC Kong, Rio J. Vetter
  • Patent number: 10493269
    Abstract: An electrical stimulation lead includes at least one lead body having a distal end portion, a proximal end portion, and a longitudinal length. The lead further includes a paddle body extending from the distal end portion of the at least one lead body, electrodes disposed along the paddle body, terminals disposed along the proximal end portion of the at least one lead body, and conductors electrically coupling the terminals to the electrodes. The lead further includes an anchoring device threadably disposed in at least a portion of the paddle body. The anchoring device has a head element and a tissue-engagement element fixed to the head element such that actuation of the head element urges the tissue-engagement element away from or toward the paddle body.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: December 3, 2019
    Assignee: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
    Inventors: William Conrad Stoffregen, Michael X. Govea, Bryan Allen Clark
  • Patent number: 10485969
    Abstract: An electrical stimulation lead includes a stimulation cuff having an exterior surface and an interior surface that defines a nerve channel having a nerve channel axis. A plurality of electrodes are disposed on the interior surface of the cuff. A longitudinal opening extends through the cuff and further extends along an entire length of the cuff, wherein the opening is operable to receive a target nerve from a region outside of the cuff to within the nerve channel. A mount is disposed on the exterior surface of the cuff and radially offset from the nerve channel axis. A lead body is radially offset from the nerve channel axis and a plurality of conductors extend through the lead body, mount and cuff, with the plurality of conductors electrically coupled to the electrodes. The electrical stimulation lead may include a plurality of slots to permit tissue ingrowth.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 26, 2019
    Assignee: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
    Inventors: Michael X. Govea, William George Orinski, William Conrad Stoffregen
  • Patent number: 10456574
    Abstract: A medical device includes telemetry circuitry configured to receive programming instructions. The medical device also includes stimulation circuitry configured to generate a plurality of electrical pulses in response to the programming instructions to provide an electrical stimulation therapy for a patient. The stimulation circuitry includes a voltage converter, a multiplexor, and a stimulation driver. At least one of the voltage converter, the multiplexer, or the stimulation driver is selectively enabled and disabled during or between the electrical pulses to reduce power consumption of the medical device.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: October 29, 2019
    Assignee: GREATBATCH, LTD.
    Inventors: Joey Chen, Kerry Bradley, Leslie Halberg
  • Patent number: 10441780
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of 30 seconds to 5 minutes of continuous stimulation. The treatment paradigm further comprises one or more daily treatment sessions that each include one or more doses for prophylactic or acute treatment of the patient's condition. Vagus nerve stimulation is used to modulate the release of inhibitory neurotransmitters in the brain, such as GABA, norepinephrine, and/or serotonin.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: October 15, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 10426955
    Abstract: The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: October 1, 2019
    Assignee: EndoStim, Inc.
    Inventors: Virender K. Sharma, Matt Joseph Gani, Paul V. Goode, Bevil Hogg, Jay Miazga, Shai Policker, Kaila Raby
  • Patent number: 10384056
    Abstract: A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. The cuff can include an elastic collar configured to exert a force on the nerve or the muscle filament to reshape the nerve or the muscle filament to the internal configuration of an opening in the elastic collar. The stimulation device can be coupled to the cuff and configured to provide a stimulation waveform to the cuff.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 20, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Dominique M. Durand, Dustin Tyler, Benjamin Cottrill
  • Patent number: 10384057
    Abstract: A multi-lead multi-electrode system and method of manufacturing the multi-lead multi-electrode system includes a multi-electrode lead that may be used to deploy multiple separable electrodes to different spaced apart contact sites, such as nerve or muscle tissues, for example, that are spatially distributed over a large area.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: August 20, 2019
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Anil K. Thota, Ranu Jung, Sathyakumar S. Kuntaegowdanahalli
  • Patent number: 10300277
    Abstract: Variable amplitude signals for neurological therapy, and associated systems and methods are disclosed. A representative method includes activating automatic delivery of an electrical therapy signal to a patient's spinal cord region at a frequency in a frequency range between 1.5 kHz and 100 kHz, via at least one signal delivery contact carried by an implanted signal delivery device. The delivery can include repeatedly and automatically delivering the electrical therapy signal at each of multiple therapy signal amplitudes to the at least one signal delivery contact, without the therapy signal generating paresthesia in the patient. The foregoing process can be used as a screening tool to screen responders from non-responders in the context of a non-paresthesia-generating therapy, and/or can be used during long-term treatment, for example, for chronic pain.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 28, 2019
    Assignee: Nevro Corp.
    Inventor: Chris Dawson
  • Patent number: 10300270
    Abstract: The present invention is related to an implantable medical device for treating breathing disorders and cardiac disorders by delivering stimulation energy to the phrenic nerve, hypoglossal nerves and cardiac muscle tissues.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: May 28, 2019
    Assignee: Respicardia, Inc.
    Inventors: Mark Gelfand, Howard R. Levin
  • Patent number: 10252063
    Abstract: A leadless intra-cardiac medical device is configured to be implanted entirely within a heart of a patient. The device includes an intra-cardiac extension and a housing. The intra-cardiac extension includes a loop body having at least one loop segment retaining at least one coil group that is configured to one or both of receive and transmit radio frequency (RF) energy, wherein the loop body is configured to extend into a first chamber of the heart. The housing is in electrical communication within the loop body, and includes a transceiver, control logic and an energy source. The housing is configured to be securely attached to an interior wall portion of a second chamber of the heart, wherein the transceiver is configured to communicate with an external device through the RF energy.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: April 9, 2019
    Assignee: PACESETTER, INC.
    Inventors: Xiaoyi Min, John W. Poore, Gene A. Bornzin
  • Patent number: 10226633
    Abstract: A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure is disclosed.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: March 12, 2019
    Assignee: AUTONOMIX MEDICAL, INC.
    Inventors: Landy Toth, Robert Schwartz
  • Patent number: 10207110
    Abstract: Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: February 19, 2019
    Assignee: Axon Therapies, Inc.
    Inventors: Mark Gelfand, Tamara Colette Baynham, Howard Levin
  • Patent number: 10206597
    Abstract: A nerve probe array has a connector made of a flexible material; and a plurality of probes coupled to the connector, each of the plurality of probe having an electrode formed at a body thereof. The plurality of probes are arranged with intervals in a length direction of the connector, and the connector surrounds an outer circumference of a nerve, and the plurality of probes pierce the outer circumference of the nerve and are inserted into the nerve.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: February 19, 2019
    Assignee: Korea Institute of Science and Technology
    Inventors: Jinseok Kim, Jong Woong Park, Jinwoo Jeong, Inchan Youn, Ockchul Kim, Sang Rok Oh, Keehoon Kim, Jun Uk Chu
  • Patent number: 10188871
    Abstract: A flat optogenetic cuff interface (FOCI) is configured for functional optical stimulation of axons in a single fascicle of a peripheral nerve bundle in which the axons have been genetically modified to express light sensitive proteins for excitation or inhibition of the nerves. The FOCI is configured to gradually reshape the single fascicle to a final height between 0.2 mm and 0.5 mm by reorganizing the individual axons within the fascicle without reshaping (and damaging) the individual axons. The FOCI facilitates stimulation of axons over the entire cross-section of the reshaped fascicle within the power limitations for pulsed laser energy. An electrical interface may be included to sense nerve activity of either the stimulated axons to provide closed-loop feedback to control the optical sources or stimulated axons of a different modality to record the response.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: January 29, 2019
    Assignee: Teledyne Scientific & Imaging, LLC
    Inventors: Stephen Simons, Jiangying Zhou, Mark A. Peot, Warren Grill, Dennis Turner
  • Patent number: 10188856
    Abstract: An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: January 29, 2019
    Assignee: Cyberonics, Inc.
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
  • Patent number: 10172549
    Abstract: A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: January 8, 2019
    Assignee: Cardionomic, Inc.
    Inventors: Steven L. Waldhauser, Steven C. Christian
  • Patent number: 10166395
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: January 1, 2019
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston
  • Patent number: 10166386
    Abstract: An electrode assembly includes a retainer, a flexible sheath, and an electrode. The retainer may include a plurality of clasping arms. The retainer is movable to an open position and a closed position. The flexible sheath is positioned below a lower surface of the retainer. The flexible sheath is at least partially surrounded by the clasping arms of the retainer. The retainer is able to hold the flexible sheath around a target tissue when the retainer is in the closed position. The electrode is configured for conducting electrical signals to or from the target tissue. The electrode is connected to at least one of the retainer and the flexible sheath. The retainer is able to hold the electrode in electrical communication with the target tissue when the retainer is disposed around the target tissue in the closed position.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: January 1, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Nilesh Raman Vasan
  • Patent number: 10154922
    Abstract: A wearable, percutaneous device for suppressing appetite or hunger in a patient includes a microprocessor, electrical stimulator and at least one percutaneous electrode implanted and configured to deliver electrical stimulation through the patient's skin. The percutaneous device includes a pad and at least one needle, in which the electrode is disposed, for secure placement of the device within the skin of a patient. The percutaneous device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: December 18, 2018
    Assignee: Elira, Inc.
    Inventors: Raul E. Perez, Peter I. Hong, Steven Diianni, Luis Jose Malave, Brad Stengel, John L. Faul
  • Patent number: 10137303
    Abstract: The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: November 27, 2018
    Assignee: Second Sight Medical Products, Inc.
    Inventors: Robert J Greenberg, David Daomin Zhou, Brian V Mech, Neil Hamilton Talbot, Rongqing Dai, Richard Agustin Castro, Kelly H. McClure
  • Patent number: 9993638
    Abstract: Conductors within an implantable medical lead that carry stimulation signal signals are at least partially embedded within a lead body of the medical lead over at least a portion of the length of the conductors while being surrounded by a radio frequency (RF) shield. A space between the shield and the conductors is filled by the presence of the lead body material such that body fluids that infiltrate the lead over time cannot pool in the space between the shield and the conductors. The dielectric properties of the lead body are retained and the capacitive coupling between the shield and the conductors continues to be inhibited such that current induced on the shield is inhibited from being channeled onto the conductors. Heating at the electrodes of the medical lead is prevented from becoming excessive.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: June 12, 2018
    Assignee: MEDTRONIC, INC.
    Inventors: Jamu K. Alford, Spencer M. Bondhus, Michael Kalm, James M. Olsen, Brian T. Stolz, Richard T. Stone, Bryan D. Stem, John D. Welter
  • Patent number: 9974597
    Abstract: A medical device including an elongate member having a proximal end configured to be electrically coupled to an energy source, and a distal member disposed at a distal end of the elongate member. The distal member may include a plurality of contact elements configured to deliver stimulating energy to innervated tissue, detect a response from the innervated tissue to the stimulating energy, and deliver therapeutic energy to the innervated tissue based on the response from the innervated tissue.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: May 22, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Manfred Franke, Bryan Allen Clark, Aiden Flanagan, Juan Hincapie Ordonez, Jason J. Hamann, Allan Shuros
  • Patent number: 9980388
    Abstract: A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 22, 2018
    Assignee: California Institute of Technology
    Inventors: Yu-Chong Tai, Han-Chieh Chang
  • Patent number: 9955882
    Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. The stimulation electrode may be a connection or self-contained component to contact a portion of a nerve. The stimulation electrode may provide or receive a signal to and/or from the nerve to assist in testing integrity of the nerve.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 1, 2018
    Assignee: MEDTRONIC XOMED, INC.
    Inventors: Matthew L. Cantwell, Bryan L. Courtney, David C. Hacker, Kevin L. McFarlin
  • Patent number: 9956398
    Abstract: A cuff for use in nerve stimulation includes a sheet of elastomer having at least one electrode and being pre-stressed so as to allow its spiral self-winding to form a cuff around the nerve. The sheet is delimited by a first width defining an outer edge of the cuff after winding, a second width defining an opposite inner edge, a first length and a second opposite length. The first width is at both ends connected to the two lengths by a respective bevel edge forming an oblique angle relative to the direction of greatest dimension of the sheet.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 1, 2018
    Assignee: Sorin CRM SAS
    Inventors: Vincent Callegari, Hervé Mével, Stéphane Béfahy
  • Patent number: 9919149
    Abstract: Devices, systems and methods are provided for stimulation of tissues and structures within a body of a patient. In particular, implantable leads are provided which are comprised of a flexible circuit. Typically, the flexible circuit includes an array of conductors bonded to a thin dielectric film. Example dielectric films include polyimide, polyvinylidene fluoride (PVDF) or other biocompatible materials to name a few. Such leads are particularly suitable for stimulation of the spinal anatomy, more particularly suitable for stimulation of specific nerve anatomies, such as the dorsal root (optionally including the dorsal root ganglion).
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: March 20, 2018
    Assignee: St. Jude Medical Luxembourg Holdings SMI S.A.R.L. (“SJM LUX SMI”)
    Inventors: Mir A. Imran, Albert G. Burdulis, Matthew G. Hills, Eyad Kishawi
  • Patent number: 9907950
    Abstract: Some implementations provide a method for modulating excitable tissue in a body of a patient, the method including: placing a wireless implantable stimulator device at a target site in the patient's body, the stimulator device including one or more electrodes; reconfiguring the wireless implantable stimulator device to form an enclosure that substantially surrounds the excitable tissue at the target site with the electrodes on the inside of the enclosure and facing the nerve; and causing electrical impulses to be delivered to the electrodes on the wireless implantable stimulator device such that neural modulation is applied to the excitable tissue substantially surrounded by the enclosure.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: March 6, 2018
    Assignee: Micron Devices LLC
    Inventors: Laura Tyler Perryman, Patrick Larson, Chad Andresen
  • Patent number: 9884192
    Abstract: A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: February 6, 2018
    Assignee: Case Western Reserve University
    Inventors: Kevin L. Kilgore, Niloy Bhadra
  • Patent number: 9861809
    Abstract: The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: January 9, 2018
    Assignee: Second Sight Medical Products, Inc.
    Inventors: Robert J. Greenberg, Eugene de Juan, Mark S. Humayun, Kelly H. McClure, Neil Hamilton Talbot, Jordan Matthew Neysmith, Brian V. Mech, James Singleton Little, Mohamed Khaldi
  • Patent number: 9849223
    Abstract: In one embodiment of the present invention, an implantable blood pump includes a housing defining a flow path, a rotor positioned within the flow path, and a motor including a stator, positioned outside of said housing, the stator including a length of silver wire, wherein the silver wire is not positioned within a hermetically sealed compartment once the blood pump is ready for implantation into a patient in need thereof. The present invention may also include a method of implanting the implantable blood pump including the step of implanting the blood pump within the patient and within or adjacent to the vasculature.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 26, 2017
    Assignee: HeartWare, Inc.
    Inventor: Jeffrey A. LaRose
  • Patent number: RE48025
    Abstract: In one embodiment, a method for maintaining patency of an upper airway of a patient to treat obstructive sleep apnea may include delivering an electrical stimulation to a portion of a superior laryngeal nerve via a nerve cuff when the nerve cuff is adjacent an external surface of the superior laryngeal nerve, the nerve cuff having a plurality of electrodes, wherein the nerve cuff is configured to be connected to an electrical stimulator via a stimulation lead.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: June 2, 2020
    Assignee: LivaNova USA, Inc.
    Inventors: Stephen L. Bolea, Thomas B. Hoegh, Bruce J. Persson, Robert E. Atkinson, Sidney F. Hauschild, Paula M. Kaplan, Brian D. Kuhnley, Keith E. Jasperson, Wondimeneh Tesfayesus, Christopher K. Thorp