Placed In Body Patents (Class 607/116)
  • Patent number: 11389649
    Abstract: Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an intermediate tubular member and an inner tubular member slidably disposed within a lumen of the intermediate tubular member. A distal holding section may extend distally of a distal end of the intermediate tubular member and define a cavity therein for receiving an implantable leadless pacing device. The device may further include a handle assembly including at least an intermediate hub portion affixed adjacent to the proximal end of the intermediate tubular member and a proximal hub portion affixed adjacent to the proximal end of the inner tubular member. A longitudinally extending groove having a proximal end and a distal end may be disposed in the intermediate hub portion. A first locking mechanism may be configured to releasably couple the intermediate hub portion and the proximal hub portion.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: July 19, 2022
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Brian Soltis, Benjamin J. Haasl, Allan C. Shuros, Brian L. Schmidt, James P. Goodman
  • Patent number: 11376431
    Abstract: An exemplary sound processor within a cochlear implant system directs a cochlear implant to concurrently apply first and second pulses by way of first and second electrodes disposed on an electrode lead configured to be inserted into a cochlea of a patient. The first and second pulses have substantially equal magnitudes and opposite phases such that the application of the first and second pulses forms a dipole that generates a field. The sound processor further directs the cochlear implant to detect, by way of a third electrode disposed on the electrode lead, an energy magnitude of the field that reflects from cochlear tissue located within the field. Based on a difference between the detected energy magnitude of the field and a baseline energy magnitude of the field, the sound processor determines a proximity of the electrode lead to the cochlear tissue. Corresponding systems and methods are also disclosed.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: July 5, 2022
    Assignee: Advanced Bionics AG
    Inventors: Kanthaiah Koka, Leonid M. Litvak
  • Patent number: 11375895
    Abstract: A method of fabricating a stretchable and flexible electronic device includes forming each of the functional layers is by: (i) forming on an elastomer substrate a conductive interconnect pattern having islands interconnected by bridges; (ii) applying a conductive paste to the islands; (iii) positioning at least one functional electronic component on each island; and (iv) applying heat to cause the conductive paste to reflow. An elastomer encapsulant is formed over the functional electronic components and the conductive interconnect pattern on each of the functional layers. The elastomer encapsulant has a Young's modulus equal to or less than that of the substrate. The encapsulant includes a pigment to increase absorption of laser light. At least one via is laser ablated, which provides electrical connection to any two functional layers. The via is filled with solder paste to create a bond and electrical connection between the functional layers.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: July 5, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sheng Xu, Yang Li
  • Patent number: 11369301
    Abstract: A device and system for providing mapping and treatment capabilities without increasing stiffness of the device. An embodiment of a device may include a flexible elongate body and at least one mapping element on the distal portion of the elongate body. Each mapping element may be an area of thermally conductive material, such as metallic nanoparticles, that is embedded within, integrated with, or deposited on the elongate body. The flexibility of the areas of thermally conductive material is at least substantially the same as that of the elongate body so the device may include many electrodes without compromising flexibility and maneuverability of the device. Alternatively, the device may include a treatment element coupled to the elongate body, such as a balloon. The mapping elements may be embedded within, integrated with, or deposited on the balloon and may have at least substantially the same flexibility as that of the balloon.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: June 28, 2022
    Inventors: Dan Wittenberger, Claudia Lueckge
  • Patent number: 11357993
    Abstract: A medical lead includes a lead body, an electrical connector, an electrical conductor, and a sleeve. The lead body includes a distal end and a proximal end defining a longitudinal axis of the lead body. The electrical connector is positioned near the proximal end of the lead body. The electrical conductor extends about the longitudinal axis of the lead body. The sleeve is coupled to an insulative material of the lead body and positioned around the electrical conductor. The electrical conductor is electrically coupled to the electrical connector. The sleeve is not fixed to the electrical conductor. In response to bending of the medical lead, the conductor may move within the sleeve to relieve strain created by the bending.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: June 14, 2022
    Assignee: Medtronic, Inc.
    Inventors: Jeffrey Zweber, Joseph Bradley, Vincent Whelan, Ian Johnson, Sean P. Skubitz
  • Patent number: 11351369
    Abstract: A stimulation probe includes a proximal end connector and a flexible wire coupled to the end connector. A handle is coupled to the wire and a needle extends from the handle and terminates at a conductive tip.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: June 7, 2022
    Assignee: MEDTRONIC XOMED, INC.
    Inventors: David C. Hacker, Wenjeng Li, Kevin Lee McFarlin
  • Patent number: 11344734
    Abstract: A hermetically sealed filtered feedthrough assembly attachable to an AIMD includes an insulator hermetically sealing the opening of a ferrule with a gold braze. The ferrule includes a peninsula extending into the ferrule opening and the insulator has a cutout matching the peninsula. A sintered platinum-containing paste hermetically seals at least one via hole extending through the insulator. At least one capacitor is disposed on the device side. An active electrical connection electrically connects the capacitor active metallization to the sintered paste. A ground electrical connection electrically connects the capacitor ground metallization disposed within a capacitor ground passageway to the portion of the gold braze along the ferrule peninsula. The dielectric of the capacitor may be less than 1,000 k.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: May 31, 2022
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Christine A. Frysz, Keith W. Seitz, Thomas Marzano, Marc Gregory Martino
  • Patent number: 11331136
    Abstract: An electrode for use on a medical device is disclosed. The electrode may have a main body of electrically conductive material extending along an axis and may have a proximal end and a distal end. The electrode may also include a magnetic resonance imaging (MRI) tracking coil disposed in the body. The MRI tracking coil may comprise electrically insulated wire. A catheter including an electrode, as well as a method for determining the location of an electrode, are also disclosed.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: May 17, 2022
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventors: Saurav Paul, Troy T. Tegg, Chou Thao, Harry A. Puryear
  • Patent number: 11324957
    Abstract: A passive implantable relay module includes a first coupler arm configured to wirelessly receive electromagnetic energy radiated through electric radiative coupling from a transmitting antenna located outside a subject's body; a second coupler arm; and a connector portion comprising a first metal core and a first dielectric coating surrounding the first metal core, the connector portion configured to connect the first coupler arm to the second coupler arm such that when the passive implantable relay module is implanted inside the subject's body and the transmitting antenna initiates wireless energy transfer to the first coupler arm via non-inductive coupling, electromagnetic waves carrying the electromagnetic energy received at the first coupler arm propagate along the first metal core to arrive at the second coupler arm, where the electromagnetic energy arriving is wirelessly transferred, again via non-inductive coupling, to a receiving antenna on a passive wireless neural stimulator device.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: May 10, 2022
    Assignee: Stimwave Technologies Incorporated
    Inventors: Richard LeBaron, Laura Tyler Perryman
  • Patent number: 11311730
    Abstract: This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: April 26, 2022
    Assignee: Lungpacer Medical Inc.
    Inventors: Joaquin Andres Hoffer, Gautam Sadarangani, Marc-Andre Nolette, Viral S. Thakkar, Bao Dung Tran
  • Patent number: 11305122
    Abstract: Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: April 19, 2022
    Assignee: Nia Therapeutics, Inc.
    Inventors: Rikky Muller, Benjamin Johnson, Igor Izyumin
  • Patent number: 11285316
    Abstract: A system and method for securing an implantable medical device to an anatomical feature, such as bony structures and/or soft tissues near the spine. The system includes a tissue fixation device and a tissue fixation device delivery tool. The tissue fixation device includes at least one bone or tissue anchor and a connecting element coupled thereto. The tissue fixation device optionally includes a flexible anchoring strap for engaging the implantable medical device. The bone or tissue anchor are configured to be deployed into the anatomical feature, and the connecting element is tightened to secure the implantable medical device to the anatomical feature.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: March 29, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Ishmael Bentley, Dale Brady, Emily Daley, Michael E. Lancial, Lawrence W. Wales, Steven L. Griffith
  • Patent number: 11278356
    Abstract: Apparatus and methods for treating and monitoring conditions such as rhinitis are disclosed herein. The technology utilizes ultrasound scans to identify target treatment sites, and monitor the treatment of a patient undergoing a treatment. The treatment may be an ablation treatment of a nasal nerve, for example the PNN for the treatment of nasal conditions, such as rhinitis. The ultrasound scans are performed within the nasal cavity with an ultrasound probe or a combined ultrasound and ablation probe and may use Doppler, A-mode, B-mode, M-mode or other ultrasound and non-ultrasound modalities to detect and monitor the target treatment sites.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: March 22, 2022
    Assignee: Arrinex, Inc.
    Inventors: Brian Fahey, William Jason Fox, Bryant Lin, Mojgan Saadat, Vahid Saadat
  • Patent number: 11278469
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising providing the subject with an acoustic energy stimulus derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: March 22, 2022
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • Patent number: 11266444
    Abstract: The present invention provides an external fixation device and method thereof. The device includes at least an insert for inserting into a patient's tissue such as a bone. The insert is fastened to a fastening assembly which comprises at least a RF heat source member during MRI scanning of the patient. At least a part of the RF heat source member's surface is covered with an absorption material to reduce the direct or indirect transfer of RF induced heat from the member to the insert. The absorption material has an electric conductivity greater than 10?4 S/m.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: March 8, 2022
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventor: Ji Chen
  • Patent number: 11266828
    Abstract: A medical lead includes a lead body, a connector, an electrical conductor, and a sleeve. The lead body includes a distal end and a proximal end defining a longitudinal axis of the lead body. The connector is positioned near the proximal end of the lead body. The electrical conductor extends about the longitudinal axis of the lead body. The sleeve is coupled to an insulative material of the lead body and positioned around the electrical conductor. The electrical conductor is electrically coupled to the connector. The sleeve includes a fixed portion that is fixed to the electrical conductor and an unfixed portion that is not fixed to the electrical conductor. In response to bending of the medical lead, the conductor may move within the unfixed portion to relieve strain created by the bending.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: March 8, 2022
    Assignee: Medtronic, Inc.
    Inventors: Jeffrey Zweber, Joseph Bradley, Vincent Whelan, Ian Johnson
  • Patent number: 11266339
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: March 8, 2022
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 11247057
    Abstract: Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods. A method for treating a patient in accordance with a particular embodiment includes selecting a neural modulation site to include a neural population of the patient's spinal cord, and selecting parameters of a neural modulation signal to at least reduce an autonomic system deficit in the patient.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: February 15, 2022
    Assignee: Nevro Corp.
    Inventor: Bradford Evan Gliner
  • Patent number: 11246655
    Abstract: A catheter configured to deliver therapeutic energy to a tissue can include can include an elongate shaft extending along a shaft longitudinal axis and comprising a shaft proximal end and a shaft distal end. The catheter can include a flexible tip assembly comprising a tip assembly outer surface, wherein the flexible tip assembly is connected to the shaft distal end and is configured to deliver therapeutic energy to the tissue, and wherein the flexible tip assembly further includes. The flexible tip assembly can include an insulative layer comprising an insulative layer outer surface, wherein the insulative layer is disposed on the tip assembly outer surface and a mapping electrode disposed on the insulative layer outer surface.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: February 15, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Alan de la Rama, Peter Chen, Cary Hata
  • Patent number: 11241280
    Abstract: A catheter apparatus for assessing denervation comprises: an elongated catheter body; a deployable structure coupled to the catheter body, the deployable structure being deployable outwardly from and contractible inwardly toward the longitudinal axis of the catheter body; one or more ablation elements disposed on the deployable structure to move outwardly and inwardly with the deployable structure; one or more stimulation elements spaced from each other and disposed on the deployable structure to move with the deployable structure, the stimulation elements being powered to supply nerve stimulating signals to the vessel; and one or more recording elements spaced from each other and from the stimulation elements, the recording elements being disposed on the deployable structure to move with the deployable structure, the recording elements configured to record response of the vessel to the nerve stimulating signals.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: February 8, 2022
    Assignee: ST. JUDE MEDICAL, INC.
    Inventor: Kok-Hwee Ng
  • Patent number: 11241573
    Abstract: Improved systems are disclosed for providing advantages during stimulation of peripheral nerves using transcutaneous, percutaneous, and implantable stimulators. Percutaneous stimulation is improved by accessories that guide the angel and depth of injection to allow for easy and controlled needle injection. Transcutaneous stimulation is improved using pressure to improve nerve recruitment. Systems and methods are disclosed for providing nerve stimulation of a patient to treat medical disorders and conditions within a single user or multiple user environments such as assisted living centers.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: February 8, 2022
    Assignee: EBT Medical, Inc.
    Inventors: Michael Sasha John, Paul B. Yoo
  • Patent number: 11234627
    Abstract: An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: February 1, 2022
    Assignee: NeuroNexus Technologies, Inc.
    Inventors: John P. Seymour, Jongeun Jeon, Nicholas Hewitt, Abeer Khurram
  • Patent number: 11224743
    Abstract: An implantable electrical stimulation lead includes at least three modular lead elements configured to couple together to form the lead, each of the modular lead elements including a proximal end portion, a distal end portion, and a male connector element or a female connector element disposed on at least one of the proximal end portion or the distal end portion of the modular lead element, The modular lead elements are coupleable together by insertion of a male connector element into a female connector element.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: January 18, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael X. Govea, Joshua Dale Howard
  • Patent number: 11224371
    Abstract: A neural interface device that comprises an implantable microelectrode body. The implantable microelectrode body includes a neural interface probe, which includes a thin film metal trace connected to an interface pad and an amorphous silicon carbide insulation. The amorphous silicon carbide insulation surrounds the thin film metal trace to form an outside surface of the neural interface probe. The interface pad is exposed to an ambient environment of the neural interface probe through an opening in the amorphous silicon carbide insulation. Methods of manufacturing the neural interface device are disclosed.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: January 18, 2022
    Assignees: Board of Regents, The University of Texas System, Trustees of Boston University
    Inventors: Timothy James Gardner, Stuart F. Cogan
  • Patent number: 11207130
    Abstract: A bipolar electrosurgical device including an outer shaft, an inner shaft, first and second electrode surfaces, and an irrigation channel. The outer shaft defines a lumen, a proximal end and a distal end forming a cutting window. The inner shaft is rotatably disposed within the outer shaft, and defines a distal portion forming a cutting tip. The cutting tip and the cutting window combine to define a cutting implement. The first and second electrode surfaces are electrically isolated, and are formed at the cutting implement. The irrigation channel extends parallel to the outer shaft, and terminates in at least one outlet port. The outlet port is proximally spaced from the cutting window and is located radially outside of the outer shaft. Fluid (e.g., saline) is emitted at the exterior surface of the device near the cutting window and is readily present for interacting with the electrode surfaces.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 28, 2021
    Assignee: Medtronic Xomed, Inc.
    Inventors: John R. Prisco, Eric P. Detmers, Wenjeng Li, David J. Little, Patrick Richart, Jose Valdez
  • Patent number: 11202917
    Abstract: In one example, a medical device includes a housing having a channel configured to receive an electrical lead. The medical device can further have a rotatable member having a longitudinal axis about which the rotatable member is configured to rotate. The rotatable member can have an outer surface having a first radius from the longitudinal axis. The rotatable member can also have a cam lobe extending farther from the longitudinal axis than the first radius of the outer surface. The cam lobe can have a substantially planar surface parallel to the longitudinal axis. The substantially planar surface of the cam lobe can be configured to retain the electrical lead within the channel. The medical device can further have a slider having a central portion substantially parallel with the cam lobe. The slider can further have a slider protrusion on the central portion of the slider.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: December 21, 2021
    Assignee: Medtronic, Inc
    Inventors: Don A. Rutledge, Greg J. Doyle
  • Patent number: 11198006
    Abstract: During charging of implantable devices via inductive coupling, heat may be produced within the implantable device, so control of the charging may be desirable to reduce or avoid the risk of undesirable tissue heating. Exchanging parameters relevant for charging may prevent undesirable heating, but typically increase the complexity of the devices used. An implantable device is provided, for wirelessly receiving energy pulses, monitoring the energy storage, and transmitting a first sufficient energy signal if the energy storage exceeds a first maximum value. An associated energy transmission device is provided, for wirelessly transmitting a plurality of successive energy pulses transmitted at a first power level, pausing energy transmission immediately after the first sufficient energy signal is received, and subsequently resuming energy pulse transmission at the first power level if no further sufficient energy signal is received.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: December 14, 2021
    Assignee: SALVIA BIOELECTRONICS B.V.
    Inventors: Rutger Nijlunsing, Hubert Martens
  • Patent number: 11197687
    Abstract: In some examples, a tool for, e.g., creating a sub-sternal tunnel in a patient or other use, is described. The tool may include a handle and a tunneling shaft coupled to the handle. The tunneling shaft extends from a proximal end to a distal end, and at least a portion of the tunneling shaft extends in a curved orientation between the first end to the distal end. The distal end of the tunneling shaft includes a cutting tool having a sharp edge. The cutting tool is moveable from a recessed position in which the sharp edge of the cutting tool is recessed into the distal end of the tunneling shaft to a deployed position in which the sharp edge of the cutting tool extends beyond the distal end of the tunneling shaft in the deployed position, e.g., to cut pericardium, scar tissue, and/or connective tissue with the sharp edge.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: December 14, 2021
    Assignee: Medtronic, Inc.
    Inventors: Garrett P. Ebersole, Kyle R. Marquard, Krishnakumar Somasundaram, Stanislaw Z. Marczyk, Linnea R. Lentz, Olesea Diaz-Chiosa, Christopher Switalski
  • Patent number: 11198001
    Abstract: Methods for automatically programming a signal generator in a patient therapy system and associated systems are disclosed. A representative method comprises retrieving data including therapy program parameters, level of efficacy, and medication use corresponding to a plurality of time periods; identifying from the data a target time period having a corresponding level of efficacy; determining from the data if medication was used during the target time period; determining from the data if medication was used during a prior time period immediately before the target time period; calculating a lead position confidence factor; and programming the signal generator to repeat therapy with the therapy program parameters corresponding to the target time period if the confidence factor is greater than a threshold value and medication was used during the prior time period and not during the target time period.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 14, 2021
    Assignee: Nevro Corp.
    Inventors: James R. Thacker, Jon Parker
  • Patent number: 11179195
    Abstract: Methods for treating polycystic kidney disease with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery of a kidney of a patient. One or more measurable physiological parameter corresponding to the polycystic kidney disease can thereby be reduced. Moreover, central sympathetic drive in the patient can be reduced in a manner that treats the patient for the polycystic kidney disease. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to cryotherapeutically cool the renal nerve or to deliver an energy field to the renal nerve.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 23, 2021
    Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.
    Inventor: Paul A. Sobotka
  • Patent number: 11179192
    Abstract: Methods and devices described herein facilitate improved treatment of body organs.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: November 23, 2021
    Assignee: AtriCure, Inc.
    Inventors: James G. Whayne, Sidney D. Fleischman
  • Patent number: 11172959
    Abstract: A method for implanting a lead includes inserting a needle into the patient; inserting a lead blank through the needle; steering the lead blank to, or near, a lead implantation site; removing the needle from the patient and leaving the lead blank; advancing a flexible sheath over the lead blank after removing the needle; removing the lead blank from the patient and leaving the flexible sheath; inserting a lead through the flexible sheath, after removing the lead blank, and implanting the lead at the lead implantation site; and removing the flexible sheath. The flexible sheath can also be used for explanting a lead and, optionally, implanting a new lead.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: November 16, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Jacob B. Leven
  • Patent number: 11173307
    Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: November 16, 2021
    Assignee: SetPoint Medical Corporation
    Inventors: Jacob A. Levine, Ralph J. Zitnik
  • Patent number: 11167138
    Abstract: A method of treating Alzheimer's Disease and/or Multiple Sclerosis and/or Minimally Conscious State and/or Mood Disorders and/or vascular brain disorders where there is small vessel compromise in a subject in need thereof, comprising applying a neuromodulation signal to the 1PAG or v1PAG of the subject.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 9, 2021
    Inventors: Nikunj Patel, Ivor Stephen Gillbe
  • Patent number: 11160973
    Abstract: A deep treatment bioelectric device includes multiple electrodes joined with a planar substrate.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: November 2, 2021
    Assignee: Vomaris Innovations, Inc.
    Inventors: Troy Paluszcyk, Michael Nagel
  • Patent number: 11154353
    Abstract: A neuromodulation catheter in accordance with a particular embodiment includes an elongate shaft and a neuromodulation element operably connected to the shaft. The shaft includes a proximal hypotube segment at its proximal end portion and a jacket disposed around at least a portion of an outer surface of the hypotube segment. The jacket may be made at least partially of a polymer blend including polyether block amide and polysiloxane. The neuromodulation element includes a distal hypotube segment and a tubular jacket disposed around at least a portion of an outer surface of the distal hypotube segment. The jacket has reduced-diameter segments spaced apart along its longitudinal axis. The neuromodulation element further includes band electrodes respectively seated in the reduced-diameter segments and respectively forming closed loops extending circumferentially around the jacket.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: October 26, 2021
    Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.
    Inventors: Don Tran, Rudy Beasley, Jaime Rios, Sukyoung Shin, Sina Som
  • Patent number: 11154706
    Abstract: Pill-sized pacemaker system including a pill-size pacemaker and a lead connector, the pacemaker having a distal end including a first screw hook and a proximal end including a first magnetic coupler, the lead connector having a distal end including a second screw hook and a proximal end including a second magnetic coupler, the first and second magnetic couplers being disc-shaped, each including at least one depth-wise electrode, wherein the first screw hook is for screwing the pacemaker to inner heart tissue and for sensing at least one signal from the inner heart tissue, the second screw hook is for screwing the lead connector to inner heart tissue and for sensing at least one signal from the inner heart tissue, and the pacemaker and the lead connector are electrically coupled via each depth-wise electrode of the first and second magnetic couplers when the first and second magnetic couplers are magnetically coupled.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: October 26, 2021
    Assignee: NewPace Ltd.
    Inventors: Robert Fishel, Gera Strommer
  • Patent number: 11147967
    Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a plurality of stimulation elements arranged configured to deliver stimulation energy through at least one of the plurality of stimulation elements to modulate aldosterone levels within the patient.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: October 19, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Lynne E Swanson, Barbara Huibregtse, Bryan A. Clark, Dennis B. Werner, Natalie A. Brill, Michael X. Govea, Umang Anand, William C. Stoffregen
  • Patent number: 11145850
    Abstract: The invention provides a neural electrode, including a current generation device, a first and a second electrode. The current generation device is connected to the first and second electrodes through a conductive metal wire respectively. At least one of the first and second electrodes is a graphene electrode. The graphene electrode has soft texture and desirable stability to tolerate the repeated pressing and folding treatment, very high charge injection efficiency, and desirable in vivo stability, and is configured to electrically stimulate tissues and organs such as hearts and nerves to promote electrical stimulation and repair of neurons, to further promote regeneration of neural functions. The invention further provides use of a mineralized three-dimensional porous graphene foam material to prepare a bone defect filler. The bone defect filler has desirable biological compatibility, promotes cell proliferation, and accelerates and induces osteogenic differentiation of bone marrow mesenchymal stem cells.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: October 12, 2021
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Judong Luo, Qi Zhang, Yuyou Qiu, Shuyu Zhang, Qin Song, Guangyu Tang, Jianping Cao, Hua Jiang
  • Patent number: 11116410
    Abstract: The invention provides a body-worn patch sensor for simultaneously measuring a blood pressure (BP), pulse oximetry (SpO2), and other vital signs and hemodynamic parameters from a patient. The patch sensor features a sensing portion having a flexible housing that is worn entirely on the patient's chest and encloses a battery, wireless transmitter, and all the sensor's sensing and electronic components. It measures electrocardiogram (ECG), impedance plethysmogram (IPG), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms, and collectively processes these to determine the vital signs and hemodynamic parameters. The sensor that measures PPG waveforms also includes a heating element to increase perfusion of tissue on the chest.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: September 14, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Erik Tang, Matthew Banet, Marshal Dhillon, James McCanna, Mark Dhillon
  • Patent number: 11117182
    Abstract: A method for fabricating electrodes sized and dimensioned to record, measure, and/or stimulate very fine nerve structures (e.g., microscale or less) is described herein. The method can include securing a tip of an electrode, comprising a conductor substantially encased by an insulator, to a proximal portion of an inserter. The electrode can be wound around a proximal portion of the inserter and a portion of the electrode can be secured to a distal portion of the inserter. A tension in the electrode can be maintained during the winding to keep the electrode in place during the winding.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: September 14, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Dominique Durand
  • Patent number: 11110263
    Abstract: A catheter apparatus can include a first magnet coupled to a catheter and a second magnet configured to couple to a patient's skin. When the catheter and the first magnet are positioned within a patient's body, the second magnet can exert a magnetic force on the first magnet that stabilizes the catheter relative to the second magnet. The second magnet can be directly attached to the patient's skin or secondary devices such as straps can be used to place the second magnet in a fixed position relative to the patient's body. In some implementations, a plurality of magnets can facilitate holding the catheter in a substantially fixed position within the patient.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: September 7, 2021
    Assignee: ABIOMED, INC.
    Inventor: Vincent Barry
  • Patent number: 11103340
    Abstract: Bio-selective textured surfaces are described which mediate foreign body response, bacterial adhesion, and tissue adhesion on devices implanted in a mammalian body. Hierarchical levels of texture, some capable of establishing a Wenzel state others a Cassie state, are employed to interface with living structures, either to promote or discourage a particular biological response/interaction. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and a desired interaction state evolves.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: August 31, 2021
    Assignee: BVW HOLDING AG
    Inventors: Lukas Bluecher, Michael Milbocker
  • Patent number: 11101427
    Abstract: Provided is a piezoelectric substrate, containing an elongate piezoelectric body that is helically wound, in which the piezoelectric body includes an optically active polypeptide, a length direction of the piezoelectric body and a main orientation direction of the optically active polypeptide included in the piezoelectric body are substantially parallel to each other, and the piezoelectric body has a degree of orientation F of from 0.50 to less than 1.00, as determined from X-ray diffraction measurement by the following Formula (a): Degree of orientation F=(180°??)/180°??(a) in Formula (a), ? represents a half width (°) of a peak derived from orientation.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 24, 2021
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Kazuhiro Tanimoto, Mitsunobu Yoshida, Katsuki Onishi
  • Patent number: 11077475
    Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: August 3, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Steven J. Holmes, Emily R. Kinser, Qinghuang Lin, Nathan P. Marchack, Roy R. Yu
  • Patent number: 11077303
    Abstract: This disclosure relates to an implantable probe for electrical stimulation of an organ and/or for detection of electrical potentials on this organ. The probe comprises a distal end able to come into contact with the tissues of the organ, this end comprising an insulating substrate, and at least one conductive interface carried by the substrate. The probe further comprises a probe body having at least one bonding conductor connected to a respective conductive interface. The conductive interface comprises at least one deformable conductive wire, at least partially exposed, with a woven, embroidered, braided or knitted configuration for anchoring the deformable wire to the substrate.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: August 3, 2021
    Assignee: Sorin CRM SAS
    Inventors: Maxime Rault, Patrick Le Gousse
  • Patent number: 11071869
    Abstract: Medical devices allow for the complete removal of a portion of an implantable component that contains a magnet. Such structure allows a recipient to undergo MRI procedures without interference from the implanted magnet. The magnet can also be contained within a larger, non-magnetic chassis that acts as an enlarged lever arm having a greater torque resistance against the generated magnetic forces.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: July 27, 2021
    Assignee: Cochlear Limited
    Inventors: Charles Roger Leigh, Padraig Hurley
  • Patent number: 11058870
    Abstract: A burr hole plug includes a base having a flange configured to rest on the skull of a patient and a sidewall configured to extend into a burr hole. The burr hole plug also includes a flexible cover configured to be disposed entirely over, and coupled to, the base. The flexible cover includes a skirt to fit around an outer perimeter of the base and a rim that fits inside the sidewall of the base. Between the skirt and the rim is an inset region having a shape corresponding to a shape of the flange of the base. Alternatively or additionally, the burr hole plug may include two lead retention members, each of the lead retention members including a lead engagement surface to engage and hold a lead; and a locking member for locking the two lead retention members in the base.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: July 13, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Zdzislaw Bernard Malinowski
  • Patent number: 11052244
    Abstract: The present disclosure relates to a bioelectric hydrogel. In one embodiment, a hydrogel comprises a hydrophilic polymer base and one or more biocompatible electrodes configured to generate at least one of a low level electric field (LLEF) or low level electric current (LLEC). The hydrogel is configured to provide a three-dimensional energy source within the hydrogel or to devises proximate to the hydrogel.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 6, 2021
    Assignee: Vomaris Innovations, Inc.
    Inventors: Wendell King, Joseph Del Rossi, Troy Paluszcyk
  • Patent number: 11052242
    Abstract: A lead wire assembly apparatus for an implantable medical device (IMD), the apparatus including a lead having first and second ends and a plurality of separate conductive segments serially located therebetween; a cover defining at least one cavity situated about ends of adjacent conductive segments; and a fluid located in the at least one cavity and coupling the adjacent conductive segments to each other. The fluid electrically couples adjacent conductive segments to pass driving signals of the implantable medical device. The fluid may further attenuate induced signals generated by radiofrequency (RF) signals of a magnetic resonance (MR) system.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: July 6, 2021
    Assignee: AVERY BIOMEDICAL DEVICES, INC.
    Inventor: Dilys Gore