Abstract: Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.

Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.

Abstract: Aspects of this disclosure describe methods and systems for phrenic nerve stimulation using a stimulation lead placed in a blood vessel. The stimulation lead includes at least one deformable segment that has at least two configurations. For example, the deformable segment may have an elongate configuration and a non-elongate configuration. In the elongate configuration, the deformable segment may be substantially straight, thereby allowing placement of the stimulation lead using a catheter. In the non-elongate configuration, the deformable segment may be a circle or spiral. The deformable segment may transition from the elongate configuration to the non-elongate configuration after the stimulation lead is positioned in the vein. The stimulation lead may be fixated to the vein at a fixation element. Additionally, the stimulation lead may include electrodes distributed along the deformable segment and at least one elongate segment.

Abstract: The lead implanted in a body to apply electrical stimulation to body organs may include: an electrode wire having one end provided as an insertion portion to be inserted into a body and the other end provided as an interface portion for connection with an external device to transmit a stimulation signal: a plurality of first electrodes in the insertion portion; a plurality of second electrodes on the interface portion; and a plurality of signal lines interconnecting the first electrodes and the second electrodes, wherein the insertion portion of the electrode wire includes a plurality of support portions on which the first electrodes are respectively disposed and a plurality of stretchable portions between the support portions and expandable and contractible, and further includes an operation unit for pushing or pulling each support portion in a longitudinal direction of the electrode wire to adjust a position of the support portion.

Abstract: A catheter includes a shaft, an expandable frame, a first set of electrodes, and a second set of electrodes. The shaft is configured for insertion into an organ of a patient. The expandable frame is fitted at a distal end of the shaft. The first set of electrodes is disposed over a distal portion of the expandable frame, and configured to be placed in contact with a tissue in the organ. The second set of electrodes is disposed on a proximal portion of the expandable frame, and configured to be inter-connected to form a common electrode.

Abstract: A device for skin-contact biological measurement includes one or more electrodes to enable signal transmission through a skin contact and a control mechanism coupled to the one or more electrodes to adjust an electrode-to-skin impedance (ESI). The control mechanism is configured to implement the ESI adjustment using a thermal actuator.

Abstract: An electrode is provided. The electrode includes a contact pad composed of boron-doped polycrystalline diamond (BDD); a fiber core composed of BDD extending longitudinally from the contact pad from a first end that is in direct contact with the contact pad to an opposing second end; and a polycrystalline diamond (PCD) cladding that coats and hermetically seals the contact pad and the fiber core. A first portion of the contact pad and a second portion at or near the second end of the fiber core are not coated and hermetically scaled by the PCD cladding. A method of fabricating the electrode is also provided.

Abstract: Embodiments of medical treatment including skin treatment using electrical energy, especially with the primary purpose for skin treatment for aesthetics are described generally herein. Other embodiments may be described and claimed.

Abstract: An implantable lead having adjustable electrode locations and a system for controlling the same. The implantable lead may include a plurality of first electrodes exposed and formed at an upper part of a main body at given intervals, a plurality of second electrodes coupled to a stepped lower part of the main body and configured to deliver a stimulus signal to a core area into which the lead is inserted, and a plurality of signal lines embedded in the main body and configured to connect the first electrodes and the second electrodes in a one-to-one manner. In this case, a slot for coupling and up and down movement of the second electrodes may be formed in the lower part. As the second electrodes are individually moved along the slot by an external force acting on the signal lines, locations of the second electrodes in the lower part may be adjusted.

Abstract: The invention is within the general field of electroporation. In particular, the invention is within the general field of endoscopic electroporation and relates to a bipolar electrode suitable for endoscopic use, i.e. an electrode assembly that can be inserted in a resectoscope and deployed so as to treat e.g. internal organs tumors, such as bladder, rectum or esophagus.

Abstract: A transvascularly placed steerable microcatheter, further including internal steerability and the ability to articulate in a direction at right angles to its longitudinal axis at or near its distal end. The steerable microcatheter is generally fabricated from stainless steel, nitinol, or other metal and includes an outer tube, an inner tube, hub structures, and a distal articulating region. The steerable microcatheter can be advanced through a body lumen in its straight configuration and then be selectively articulated or curved to permit negotiation of tortuous curvature. The microcatheter is especially suited to robotic or powered control applications with user intervention or using artificial intelligence (AI).

Abstract: Provided is a system, which includes: a radio frequency (RF) generator including an RF power, an RF signal generator configured to be initiated by the RF power and generates an RF signal; a heating apparatus including a first pouch having a first inlet tube, a second pouch having a second inlet tube connected to the first pouch, a first RF electrode in the first pouch and a second RF electrode in the second pouch, wherein the first RF electrode and the second RF electrode are configured to receive the RF signal; and a liquid reservoir operatively connected to the first inlet tube of the first pouch. Also provided is a method for treating a cancer in a subject in need thereof by using the system.

Abstract: A pressure/force sensor comprises a diaphragm structure including a sensing element and a lead structure extending from the diaphragm structure and including first and second traces electrically coupled to the sensing element. The diaphragm structure and the lead structure include a circuit assembly comprising a common insulating layer and a common conductor layer on the insulating layer. The conductor layer includes at least a portion of the sensing element and at least the first trace.

Abstract: Disclosed is electrical apparatus for stimulating and/or monitoring an eye of a patient, comprising an implantable electrode device and a lead extending outwardly from the implantable device, the lead including a section that locates externally to the eye having at least one pre-formed bend. Also disclosed is a lead connected to an implantable electrode device, the lead having one or more stripes that extend along at least a portion of the lead. Also disclosed is an implantable device having a substrate and at least one electrode, the electrode having at least one aperture through which material of the substrate extends to anchor the electrode to the substrate. Other disclosed features relate to a foldable anchor device, a curved electrode substrate and depth markers, for example.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing that is configured to anchor the device to a bone, and an electrode that is configured to contact an organ. The clip includes a top portion that is rigid, a bottom portion that is rigid, and an intermediate portion between the top portion and the bottom portion that is configured to permit movement of the top portion with respect to the bottom portion and thereby apply force onto the bone between the top portion and the bottom portion.

Abstract: Extravascular implant tools that utilize a bore-in mechanism to safely access extravascular locations and implant techniques utilizing these tools are described. The bore-in mechanism may include a handle and a helix extending from the handle. The bore-in mechanism is used, for example, in conjunction with a tunneling tool to traverse the diaphragmatic attachments to access a substernal location. The tunneling tool may be an open channel tunneling tool or a conventional tunneling tool (e.g., metal rod).

Abstract: Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter 5 into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.

Abstract: The present disclosure generally provides methods of implanting an implantable device in contact with a brain of a subject. Also provided are kits and systems for the implantation of one or more implantable devices.

Abstract: Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.

Abstract: An energy conveying structure for invasive electrosurgery that provide for combined delivery of (i) RF or microwave electromagnetic energy for tissue treatment (e.g. ablation, coagulation or cutting), and (ii) optical radiation within a common structure that may form an instrument cable of a surgical scoping device. The structure resembles a hollow coaxial transmission line with an optical channel formed within it. The optical channel can lie within a passage that is formed within the inner conductive layer or within other layers of the coaxial transmission. The structure may be used to form an electrosurgical device capable of delivering RF/microwave EM energy, optical radiation and ultrasonic signals to a treatment site along an instrument cable of a surgical scoping device.

Abstract: Methods and devices described herein facilitate improved treatment of body organs.

Abstract: An instrument includes a sleeve extending between proximal and distal ends. The sleeve defines a passageway. The distal end defines an engagement portion including an engagement surface extending from a first end to a second end. A peg extends outwardly from the first end. An opening that is in communication with the passageway extends through the second end. A knob is coupled to the proximal end. A shaft includes a proximal end and an opposite distal end. The distal end of the shaft includes a mating portion. The mating portion extends through the opening. The proximal end of the shaft is coupled to the knob. The knob is rotatable relative to the sleeve to rotate the shaft relative to the sleeve. Methods of use are disclosed.

Abstract: A lead device is provided for a medical treatment apparatus, where the lead device includes mechanisms for anchoring the lead device in tissue.

Abstract: A medical device is provided, including: a therapeutic subsystem to deliver a medical therapy, including a sensor to monitor a biometric health factor; a user interface; a controller, including a processor and a memory; therapy software including instructions encoded within the memory to instruct the processor to receive a prescribed therapy, to receive a therapeutic setting recommendation, and to display the therapeutic setting recommendation to an operator via the user interface; a network interface, and instructions to receive, via the network interface, a prepared artificial intelligence (AI) model from a cloud service; and an AI circuit having execution hardware including at least one logic gate, and further including instructions to instruct the execution hardware to execute the prepared AI model to provide a recommended therapy setting for the therapeutic subsystem, wherein the circuit is further to incorporate into the prepared AI model data from the sensor.

Abstract: A concentric ring electrode (CRE) is provided that can sense characteristics of an electric potential, such as its Laplacian, more accurately than previous systems. The disclosed system and methods can optimize estimates of the Laplacian based on potentials measured by the CRE's electrodes, and can optimize the geometry of the CRE, in particular the ring electrodes' radii. Given the CRE's geometrical configuration, the system estimates the Laplacian's dependence on the measured potentials by computing a null space of a matrix associated with a series expansion of the potential. The system determines coefficients for the dependence, wherein a first coefficient is between ?10 and 10 times, or between ?6.5 and ?7.5 times, a second coefficient. The system can optimize ranges for the radii by canceling at least one truncation term of the series expansion, estimating a higher-order truncation term as a function of the radii, and minimizing this estimated function.

Abstract: A lead body having a defibrillation electrode positioned along a distal portion of the lead body is described. The defibrillation electrode includes a plurality of electrode segments spaced a distance apart from each other. At least one of the plurality of defibrillation electrode segments includes at least one coated portion and at least one uncoated portion. The at least one coated portion is coated with an electrically insulating material configured to prevent transmission of a low voltage signal (e.g., a pacing pulse) while allowing transmission of a high voltage signal (e.g., a cardioversion defibrillation shock). The at least one uncoated portion is configured to transmit both low voltage and high voltage signals. The lead may also include one or more discrete electrodes proximal, distal or between the defibrillation electrode segments.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing that is configured to anchor the device to a bone, and an electrode that is configured to contact an organ. The clip includes a top portion that is rigid, a bottom portion that is rigid, and an intermediate portion between the top portion and the bottom portion that is configured to permit movement of the top portion with respect to the bottom portion and thereby apply force onto the bone between the top portion and the bottom portion.

Abstract: A lead adapter for a patient treatment system comprises a housing having a plurality of inlets, each inlet being segregated from an immediately adjacent inlet by a housing intermediate wall. A plurality of electrical contact assemblies residing in the housing are electrically connected to a respective one of a plurality of electrical contact posts. Each contact post has an exposed terminal portion residing in one of the plurality of inlets. A header is movably secured to the housing to selectively open and close the housing. With the header in an open position, an implantable lead is movable into a longitudinally extending opening in the header. The header is then manipulatable into a closed position to move an electrical contact of the lead into contact with a respective one of the electrical contact assemblies electrically connected to a respective one of the electrical contact posts.

Abstract: A device and system for providing a centered lumen within a catheter body. A coiled guide lumen (CGL) is composed of a length of wire forming a plurality of coils about the longitudinal axis of the CGL, the CGL including one or more first sections having a first diameter and one or more sections having a second diameter, the second diameter being greater than the first diameter, and a secondary guide lumen extending through the first sections. The CGL may include at least one pull wire extending through the secondary guide lumen and attached at the distal portion of the catheter body. A band may be coupled to an interior of the catheter body distal portion, each of the pull wires being coupled to the annular band. Alternatively, the system may further include a shim coupled to the band, each of the pulls wire being coupled to the shim.

Abstract: A method for the removal of paint from a surface using a molecular adhesive comprising: applying an anionic coating to the paint to be removed; placing a pulling medium in contact with said anionic coating; said pulling medium comprising a substrate having a surface comprising a conductive polymer nanotube array; applying an electric potential across said pulling medium and said anionic coating to facilitate ionic bonding between said conductive polymer nanotube array and said anionic coating; and applying force to said pulling medium to pull away said pulling medium from said surface and thereby removing the paint which is bonded to said anionic coating which is bonded to said conductive polymer nanotube array.

Abstract: An auxiliary tool for surgery includes an auxiliary tool main body part, and a first leg pair located on the auxiliary tool main body part. A tail end of the first leg pair is connected to the auxiliary tool main body part, a first mounting part is formed at a front end of the first leg pair, and the first mounting part is configured to clamp and press a surgical device to place the surgical device in a predetermined position.

Abstract: A mismatch in curvature of an electrode lead section may create unexpected and/or unpredictable electrical resistance with underlying tissue. In addition, repeated movement of the relevant areas of the body may even worsen the mismatch. Implants for electrical stimulation require low electrical resistance conductors for stimulation electrodes, return electrodes and interconnections which conventionally use metal for wires and contacts. These conductors reduce the flexibility, and the problem becomes worse as the number of electrodes increases. An implantable stimulation device is provided with an elongated substrate, one or more interconnections, a flexible electrode with two portions, separated by one or more bending interruptions, wherein the first portion and second portion are in direct electrical connection through the one or more interconnections.

Abstract: A guidewire, consisting of a flexible biocompatible tube, having a tube distal end, the tube containing an internal lumen and being configured to be inserted into an orifice of a body of a living subject. A planar resilient strip is inserted into the internal lumen, the strip having a strip proximal end and a strip distal end fixed to the tube distal end. A coil spring is fixed to the strip proximal end so that an axis of symmetry of the coil is coplanar with the strip, the coil spring containing a coil lumen. A wire is threaded through the coil lumen and has a termination fixed to the strip distal end, so that pulling on the wire causes the strip and the tube to bend.

Abstract: Embodiments relate to implantable-lead devices that include one or more materials with altered morphology and methods for making and using the same. Specifically, the morphology of electrodes and/or one or more other implant-device materials can be textured to include micro- and/or nanoscale topographical features, which can reduce in vivo fibrotic response and thereby improve signal-to-noise ratios and short-term extractability of the devices.

Abstract: An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair.

Abstract: An electrode assembly for the positioning of an electrode of an implantable medical lead includes a housing and an electrode subassembly. The housing includes a proximal end for connecting to the lead and a distal end. The housing defines a housing lumen extending between the proximal end and the distal end. The housing lumen includes internal screw threads extending along at least a portion of the housing lumen. The electrode subassembly is disposed at least partially within the housing lumen. The electrode subassembly includes a needle electrode and a coupler. The needle electrode is disposed coaxially with the longitudinal axis of the housing lumen. The coupler is disposed at a proximal end of the needle electrode. The coupler includes external screw threads engaged with the internal screw threads of the housing lumen such that rotation of the coupler moves the needle electrode along the longitudinal axis of the housing lumen.

Abstract: Disclosed are compositions for and methods of altering the electric impedance to an alternating electric field in a target site of a subject. Disclosed are compositions for methods of improving transport of a nanoparticle across a cell membrane of a cell.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing that is configured to anchor the device to a bone, and an electrode that is configured to contact an organ. The clip includes a top portion that is rigid, a bottom portion that is rigid, and an intermediate portion between the top portion and the bottom portion that is configured to permit movement of the top portion with respect to the bottom portion and thereby apply force onto the bone between the top portion and the bottom portion.

Abstract: Various embodiments of an electronic package and implantable medical device are disclosed. The electronic package includes a nonconductive substrate having a first major surface, a second major surface, and an opening disposed through the substrate between the first major surface and the second major surface. The package also includes a conductive layer hermetically sealed to the first major surface of the substrate and over the opening; a conductor block disposed in the opening and extending beyond the second major surface of the substrate, where the conductor block is electrically connected to the conductive layer; and an electronic device disposed adjacent to the first major surface of the substrate and electrically connected to the conductive layer. The package also includes a nonconductive cover disposed over the electronic device and the nonconductive substrate and hermetically sealed to the substrate, where the electronic device is disposed within a cavity of the cover.

Abstract: A controller and associated multi-axis sensor system for augmenting the automatic intelligent delivery of one or more drugs is provided. The controller and associated multi-axial sensor system are based on the detection and determination of particular physical lifestyle events. As a specific example, a pump augmentation system includes a six-axis accelerometer sensor, a gyroscopic pitch sensor and a controller. The controller is configured to receive motion data from the six-axis accelerometer sensor and orientation data from the gyroscopic pitch sensor. The controller provides a pump instruction signal for changing a delivery rate of a drug to a user based on the motion data and the orientation data. The system and methods are particularly suited for treating a user with Parkinson's disease.

Abstract: Seals used within lead passageways of implantable medical devices for creating a seal to implantable medical leads inserted into the lead passageways include a body defining a lead passageway with an axial dimension. The body further defines a first circumferential protrusion extending radially a first distance into the lead passageway, and the body further defines a second circumferential protrusion separated from the first circumferential protrusion along the axial dimension. The second circumferential protrusion extends radially a second distance into the lead passageway, the second distance being less than the first distance. The body further defines a first circumferential depression immediately adjacent the first circumferential protrusion and between the first circumferential protrusion and the second circumferential protrusion.

Abstract: Techniques for determining the location of a physiological midline are disclosed. A first technique evaluates the response to stimulation of spinal electrodes at peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on a relationship between responses to its stimulation observed on different sides of the body. A second technique evaluates the response of spinal electrodes to stimulation of peripheral electrodes on different sides of the body. In this technique, a spinal electrode's position relative to a physiological midline is determined based on the different responses that it observes to stimulation on different sides of the body.

Abstract: Devices and methods for providing neurostimulation to a patient, particularly in trial systems assessing suitability of a permanently implanted neurostimulation, are provided herein. In one aspect, a trial neurostimulation lead includes a coiled conductor coupled to a proximal contact connector having a retention flange that withstands tensile force from tension in the lead so as to maintain the electrical connection during a trial period. In another aspect, a trial neurostimulation system includes a lead extension that includes a regression stopper between the implanted distal connector and proximal lead disposed outside the body to prevent regression of the lead through a secondary incision, thereby preventing infection and facilitating explant of the system. Methods of assembling and utilizing such leads and systems are detailed herein.

Abstract: A lead engagement device is configured to be positioned in a lead lumen. The lead engagement device includes a hypotube. The hypotube includes a wall having an inner surface defining an inner lumen and an outer surface. The wall defines a longitudinal axis of the hypotube. A plurality of lead engagement fingers extend outwardly and proximally from the outer surface at acute angles, and planes in which the acute angles are disposed extend diagonally relative to the longitudinal axis. The plurality of lead engagement fingers are configured to translate relative to the lead and permit relative motion between the lead engagement device and the lead when applying a first force to the lead engagement device. The plurality of lead engagement fingers are configured to engage the lead and inhibit relative motion between the lead engagement device and the lead when applying an opposite second force to the lead engagement device.

Abstract: Embodiments herein relate to systems and methods for thawing cells using magnetic particles, such as Curie-magnetic or Néel-magnetic particles. In an embodiment, a cell storage medium for cryopreservation is included. The cell storage medium can include a cryoprotective agent; and a plurality of particles comprising a magnetic material. In an embodiment, a method for thawing a frozen cell sample is included. The method can include obtaining a frozen cell sample comprising particles, the particles comprising a magnetic material and applying an alternating electromagnetic field to the frozen cell sample to induce heating of the magnetic material. Other embodiments are also included herein.

Abstract: A projectile for piercing a casing of a mine containing an explosive material. The projectile includes a projectile body having a nose portion and a tail portion and a longitudinal axis, a switch, and electrodes separated such that in use an electrical discharge can flow between them through an explosive material contained within a mine, or to initiate an energetic material provided between the electrodes to detonate an explosive material contained within a mine. Also provided is a method of mine disposal.

Abstract: An electrode contact for an electrode lead for neurostimulation comprises a contact body including a contact surface for contacting human or animal neural tissue. The electrode contact furthermore comprises an arm section for contacting at least one electrical supply lead, wherein the arm section, originating from the contact body, extends laterally in a first spatial direction which runs parallel to a main extension plane of the contact surface. The arm section includes at least one cut-out for guiding through the at least one electrical supply lead.

Abstract: Disclosed herein is a catheter for delivering an implantable medical lead to an implantation site near an ostium leading to a proximal region of a coronary sinus. The catheter includes a distal end, a proximal end opposite the distal end, a tubular body extending between the distal and proximal ends, an atraumatic fixation structure defining a distal termination of the distal end, and a lead receiving lumen. The atraumatic fixation structure is configured to enter the ostium and passively pivotally anchor with the proximal region of the coronary sinus. The lead receiving lumen extends along the tubular body from the proximal end to an opening defined in a side of the tubular body near the distal end and proximal the atraumatic fixation structure.