Regulating Or Compensating Stimulus Level Patents (Class 607/11)
  • Patent number: 8755882
    Abstract: Embodiments of close loop optimization of atrio-ventricular (A-V) delay interval and/or inter-ventricular (V-V) timing are disclosed. An implantable medical device includes a housing that supports a processing means adapted for implantation in a patient. There can be two or more electrodes electrically coupled to the processing means where the two or more electrodes can be used for sensing a patient's cardiac signals, which include a far-field EGM. The processing means can determine a width of a P-wave from the sensed far-field EGM. Also included can be a means for delivering an adapted cardiac pacing therapy based upon the width of the P-wave, including revised A-V delay and/or V-V temporal intervals.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: June 17, 2014
    Assignee: Medtronic, Inc.
    Inventor: Li Wang
  • Patent number: 8744571
    Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: June 3, 2014
    Assignee: Cedars-Sinai Medical Center
    Inventors: Peng-Sheng Chen, Shengmei Zhou
  • Patent number: 8718762
    Abstract: A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: May 6, 2014
    Assignee: Medtronic, Inc.
    Inventors: Mark L. Brown, Troy Edward Jackson, Jeffrey M. Gillberg
  • Publication number: 20140121718
    Abstract: Various embodiments intermittently deliver a sympathetic stimulus, including deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further delivers neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Allan C. Shuros, Shantha Arcot-Krishnamurthy, Bruce H. KenKnight, Douglas R. Daum
  • Patent number: 8700155
    Abstract: An implantable medical device (IMD) having a therapy circuit for delivering atrial pacing and a control circuit for detecting a return to sinus rhythm. The control circuit determines the duration of an atrial arrhythmia preceding the return to sinus rhythm, and controls the therapy circuit to deliver transient atrial pacing based on the atrial arrhythmia duration.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: April 15, 2014
    Assignee: Medtronic, Inc.
    Inventors: Douglas A. Hettrick, David E. Euler
  • Publication number: 20140100624
    Abstract: An implantable medical device may comprise a therapy module configured to generate pacing therapy for a heart of a patient and a control module configured to control the therapy module. The control module may also be configured to detect a condition indicative of the presence of a magnetic resonance imaging (MRI) device and switch operation from a first pacing therapy program to a second pacing therapy program in response to detecting the condition indicative of the presence of the MRI device. While operating in the second pacing therapy program, control module may control the therapy module to generate a pacing pulse to an atrium of the heart of the patient during a time period between the end of an atrial refractory period of a previous atrial depolarization and the end of a ventricular refractory period of a previous ventricular depolarization corresponding to the previous atrial depolarization.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 10, 2014
    Applicant: MEDTRONIC, INC.
    Inventor: Michael L. Ellingson
  • Publication number: 20140088661
    Abstract: According to various method embodiments for pacing a heart and avoiding unwanted stimulation of a phrenic nerve during cardiac pacing, a desired pacing time for delivering a cardiac pace is determined, and a desired nerve traffic inhibition time to inhibit nerve traffic in the phrenic nerve is determined using the desired pace time. The cardiac pace is delivered at the desired pacing time and nerve traffic in the phrenic nerve is inhibited at the desired nerve traffic inhibition time.
    Type: Application
    Filed: December 2, 2013
    Publication date: March 27, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Juan Gabriel Hincapie Ordonez, Holly Rockweiler
  • Publication number: 20140052200
    Abstract: Systems, methods, and devices for protecting against effects of magnetic fields are provided. One implantable medical device includes a lead including a first conductor and a second conductor. The device further includes a generator including an electronic circuit, a metal housing that has a ground potential, and one or more switching devices. The switching devices, in a safekeeping configuration, are configured to disconnect the second conductor from the electronic circuit and to connect the second conductor to the ground potential of the metal housing. The first conductor is connected to the electronic circuit in the safekeeping configuration. The switching devices, in the safekeeping configuration, are configured to cause the second conductor to shield the first conductor from at least a portion of the effects of the magnetic field while the first conductor remains connected to the electronic circuit for use in performing a sensing operation and/or a stimulation operation.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 20, 2014
    Inventor: Thierry Legay
  • Publication number: 20140046392
    Abstract: Energy delivered from an implantable medical device to stimulate tissue within a patient's body is controlled. An electrical signal used to stimulate the tissue is changed from a first energy state to a second energy state during a magnetic resonance imaging (MRI) scan. The energy delivered is maintained at the second energy state after the MRI scan. A capture threshold of the tissue is then measured, and the energy delivered to the tissue is adjusted based on the measured capture threshold of the tissue.
    Type: Application
    Filed: October 14, 2013
    Publication date: February 13, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Scott R. Stubbs, Kevin G. Wika
  • Publication number: 20140039568
    Abstract: An implantable medical device detects a strong static magnetic field associated with an MRI imaging instrument and operates in a safekeeping operating mode. The device includes an electronic circuit for the detection/stimulation of a cardiac activity, a weak field sensor detecting the presence of a first magnetic field of a permanent magnet being located in proximity to the device, a strong field sensor detecting the presence of a second magnetic field of an MRI imaging instrument during the course of an MRI examination.
    Type: Application
    Filed: October 8, 2013
    Publication date: February 6, 2014
    Applicant: SORIN CRM S.A.S.
    Inventor: Thierry Legay
  • Patent number: 8639336
    Abstract: A method for operating an implantable medical device includes delivering a plurality of pacing pulses to an atria of a patient's heart and monitoring intrinsic atrial activity to detect intrinsic atrial contractions between one or more of the plurality of pacing pulses. The method further includes detecting atrial undersensing as a function of the detection of intrinsic atrial contractions.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: January 28, 2014
    Assignee: Pacesetter, Inc.
    Inventors: Gene A. Bornzin, Peter Boileau, Jeffery D. Snell
  • Patent number: 8639329
    Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: January 28, 2014
    Assignee: Georgia Tech Research Corporation
    Inventors: Edgar A. Brown, James D. Ross, Richard A. Blum, Stephen P. DeWeerth
  • Publication number: 20140018872
    Abstract: An example of a system comprises a cardiac pulse generator configured to generate cardiac paces to pace the heart, a sensor configured to sense a physiological signal for use in detecting pace-induced phrenic nerve stimulation (PS), a storage, and a phrenic nerve stimulation detector. The storage is configured for use to store patient-specific PS features for PS beats with a desirably large signal-to-noise ratio. The phrenic nerve stimulation detector may be configured to detect PS features for the patient by analyzing a PS beat with a desirably large signal-to-noise ratio induced using a pacing pulse with a large energy output and store patient-specific PS features in the storage, and use the patient-specific PS features stored in the memory to detect PS beats when the heart is paced heart using cardiac pacing pulses with a smaller energy output.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 16, 2014
    Inventors: Krzysztof Z. Siejko, Sunipa Saha, Aaron R. McCabe, Holly Rockweiler
  • Publication number: 20140018870
    Abstract: One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Daniel J. Cooke, Jeffrey A. Von Arx
  • Patent number: 8620428
    Abstract: According to various method embodiments for pacing a heart and avoiding unwanted stimulation of a phrenic nerve during cardiac pacing, a desired pacing time for delivering a cardiac pace is determined, and a desired nerve traffic inhibition time to inhibit nerve traffic in the phrenic nerve is determined using the desired pace time. The cardiac pace is delivered at the desired pacing time and nerve traffic in the phrenic nerve is inhibited at the desired nerve traffic inhibition time.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: December 31, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Juan Gabriel Hincapie Ordonez, Holly Rockweiler
  • Patent number: 8612001
    Abstract: A cardiac rhythm management device in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: December 17, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: Rodney W. Salo
  • Patent number: 8600499
    Abstract: A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: December 3, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan C. Shuros, Shantha Arcot-Krishnamurthy, Joseph Walker
  • Patent number: 8600504
    Abstract: Physiologic demand driven pacing can be used to maintain cardiac synchrony and improve hemodynamic function in patients with heart failure.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: December 3, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Donald L. Hopper, Yinghong Yu, David J. Ternes
  • Publication number: 20130317562
    Abstract: A lead for an implantable cardiac prosthesis having an integrated protection against the effects of magnetic resonance imaging (“MRI”) fields. A protection circuit (26) may be placed at the distal end of the lead comprises a resistive component (28) interposed between the electrode (E1, E2) and the distal end of the conductor (22, 24) associated with this electrode. A normally-open controlled active switch (34, 36) may allow in its closed state to short-circuit the resistive component. A control stage (32) may be coupled to the conductors and detect the voltage of a stimulation pulse applied on the conductor(s), and selectively control by this voltage the closing of the active switch for a duration at least equal to the duration of detected stimulation pulse.
    Type: Application
    Filed: August 5, 2013
    Publication date: November 28, 2013
    Applicant: Sorin CRM S.A.S.
    Inventor: Alaa Makdissi
  • Publication number: 20130317561
    Abstract: Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.
    Type: Application
    Filed: July 30, 2013
    Publication date: November 28, 2013
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, William J. Linder, Jeffrey E. Stahmann
  • Patent number: 8588894
    Abstract: Techniques include determining a first vector of temporal changes in electrical data measured at multiple electrical sensors positioned at corresponding locations on a surface of a living body due to a natural electrical pulse. A different vector of temporal changes in electrical data measured at the same electrical sensors is determined due to each stimulated signal of multiple stimulated signals within the living body. Stimulated position data is received, which indicates a different corresponding position within the living body where each of the stimulated signals originates. The site of origin of the natural electrical pulse is determined based on the first vector and the multiple different vectors and the stimulated position data. Among other applications, these techniques allow the rapid, automatic determination of the site of origin of ventricular tachycardia arrhythmia (VT).
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: November 19, 2013
    Assignee: University of Maryland, Baltimore
    Inventors: Magdi M. Saba, Stephen R. Shorofsky
  • Patent number: 8583232
    Abstract: A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodymanic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: November 12, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Barun Maskara, Lili Liu, Guy Alvarez, Scott A. Meyer
  • Patent number: 8583219
    Abstract: In a possible implementation, a method for cardiac testing is provided which includes measuring test data associated with cardiac events and storing the test data in an intracardiac stimulation device. The method further includes acquiring event electrograms corresponding with the test data and storing the event electrograms corresponding with the test data in the intracardiac stimulation device. In a possible implementation, marker data is stored associating event electrograms with measured test data, which may identify the event electrograms used for measuring the test data and/or identify when adjacent event electrograms are not contiguous. In some implementations, the test data may be measured and stored in an out-of-clinic test, and the test data and the corresponding event electrograms may be later retrieved from the intracardiac stimulation device and presented on a visual display.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 12, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Jennifer Rhude, Elia A. Mouchawar, David Houck, Gregory Hauck, Tejpal Singh, Monique Prue
  • Patent number: 8565865
    Abstract: Methods for determination of timing for electrical shocks to the heart to determine shock strength necessary to defibrillate a fibrillating heart. The timing corresponds the window of most vulnerability in the heart, which occurs during the T-wave of a heartbeat. Using a derivatized T-wave representation, the timing of most vulnerability is determined by a center of the area method, peak amplitude method, width method, or other similar methods. Devices are similarly disclosed embodying the methods of the present disclosure.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 22, 2013
    Assignees: Medtronic, Inc., Imperception, Inc.
    Inventors: Paul A. Belk, Jian Cao, Jeffrey M. Gillberg, Charles D. Swerdlow
  • Patent number: 8565874
    Abstract: An implantable medical device (IMD) includes a lead having one or more sensing electrodes and one or more therapy delivery electrodes, and a sensor configured to detect the presence of static and time-varying scan fields in a magnetic resonance imaging (MRI) environment. A controller, in electrical communication with the lead and the sensor, is configured to process signals related to tachycardia events sensed via the one or more sensing electrodes and to deliver pacing and shock therapy signals via the one or more therapy delivery electrodes. The controller compares the sensed static and time-varying scan fields to static and time-varying scan field thresholds. The controller controls delivery of anti-tachycardia pacing and shock therapy signals as a function of the detected tachycardia events, the comparison of the sensed static scan field to the static scan field threshold, and the comparison of the time-varying scan fields to the time-varying scan field thresholds.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: October 22, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Scott R. Stubbs, James O. Gilkerson, Hiten J. Doshi, Diane Schuster
  • Patent number: 8560076
    Abstract: Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: October 15, 2013
    Assignee: CVRx, Inc.
    Inventors: Robert S. Kieval, Martin Rossing
  • Patent number: 8560081
    Abstract: Power management methods, systems and circuitry are provided for efficiently energizing implanted stimulators. Efficiency is achieved by automatically adjusting the power-supply voltage of the stimulator channel so that the magnitude of the voltage of the current-sink or current-source providing the stimulation current is regulated within a narrow band just above the minimum acceptable level. Adjustment is done once in every cycle of the external high-frequency power source in order to achieve regulation with a very fine time resolution throughout each stimulation period. The power supply voltage is generated and adjusted by rectifying the high-frequency voltage of the secondary coil of a transcutaneous magnetic link by closing and opening a solid-state switch at appropriate times during positive half cycles for a current-sink, and during negative half-cycles for a current-source.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: October 15, 2013
    Assignee: Yeditepe Universitesi
    Inventor: Ugur Cilingiroglu
  • Patent number: 8560056
    Abstract: In a possible implementation, a method for cardiac testing is provided which includes measuring test data associated with cardiac events and storing the test data in an intracardiac stimulation device. The method further includes acquiring event electrograms corresponding with the test data and storing the event electrograms corresponding with the test data in the intracardiac stimulation device. In a possible implementation, marker data is stored associating event electrograms with measured test data, which may identify the event electrograms used for measuring the test data and/or identify when adjacent event electrograms are not contiguous. In some implementations, the test data may be measured and stored in an out-of-clinic test, and the test data and the corresponding event electrograms may be later retrieved from the intracardiac stimulation device and presented on a visual display.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: October 15, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Jennifer Rhude, Elia A. Mouchawar, David Houck, Gregory Hauck, Tejpal Singh, Monique Prue
  • Publication number: 20130268014
    Abstract: A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 10, 2013
    Inventors: Allan C. Shuros, Tamara Colette Baynham, Jihong Qu, Joseph M. Pastore, Andrew P. Kramer, Frits W. Prinzen, Ward Y.R. Vanagt, Richard N. Cornelussen
  • Publication number: 20130268015
    Abstract: A constant current pacing apparatus and method for pacing uses, for example, H-bridge circuitry and a constant current source connected to the H-bridge circuitry. Further, for example, protection is provided from high voltage pulses applied to the patient via one or more other medical devices.
    Type: Application
    Filed: May 28, 2013
    Publication date: October 10, 2013
    Applicant: MEDTRONIC, INC.
    Inventor: Kevin A. Wanasek
  • Patent number: 8554318
    Abstract: An active implantable medical device for one of cardiac stimulation, resynchronization, and defibrillation is shown and described. The device includes means for placing an electronic circuit in a safekeeping operating mode in response to detecting a first magnetic field associated with a permanent magnet and detecting a second magnetic field associated with an MRI imager.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: October 8, 2013
    Assignee: Sorin CRM S.A.S.
    Inventor: Thierry Legay
  • Patent number: 8545414
    Abstract: Methods and devices for modulating heart valve function are provided. In the subject methods, a heart valve is first in structurally modified. Blood flow through the structurally modified heart valve is then monitored, and the heart is paced in response to the monitored blood flow. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods find use in a variety of applications.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: October 1, 2013
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter J. Fitzgerald, Ali Hassan, Brian K. Courtney, Nicolas A. F. Chronos, Richard G. Cartledge, Leonard Y. Lee
  • Publication number: 20130238044
    Abstract: An implantable stimulation system comprises an implantable stimulator and a control device. The control device is configured to transmit acoustic waves to the implantable stimulator, and the implantable stimulator is configured to transform the acoustic waves into electrical current, and generate stimulation energy based on the electrical current. For example, the electrical current can be transformed into electrical energy that can be used to generate the stimulation energy. Or the electrical current can contain signals used to directly or indirectly control the generation of the stimulation energy.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 12, 2013
    Applicant: REMON MEDICAL TECHNOLOGIES, LTD.
    Inventor: Abraham Penner
  • Patent number: 8532767
    Abstract: A device for medical applications, comprising an elongated conductive element having one proximal end and one distal end, wherein the latter undergoes a temperature increase by absorbing energy from an electromagnetic field, comprising a separating element disposed in the elongated conductive element for the galvanic separation of the proximal end from the distal end.
    Type: Grant
    Filed: April 22, 2012
    Date of Patent: September 10, 2013
    Assignee: Biotronik SE & Co. KG
    Inventors: Thomas Doerr, Ingo Weiss
  • Patent number: 8527051
    Abstract: The present invention provides implantable medical devices for detecting phrenic nerve stimulation. A pacing module is configured to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles, and the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. An impedance measurement module is configured to measure impedance signals in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle. A phrenic nerve stimulation, PNS, detection module is configured to gather at least one impedance signal from each time window, create aggregated impedance signals using the impedance signals from the different time windows, and analyze the aggregated impedance signals to detect PNS.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: September 3, 2013
    Assignee: St. Jude Medical AB
    Inventors: Sven-Erik Hedberg, Tomas Svensson, Kjell Noren, Stuart Rosenberg, Kyungmoo Ryu, Edward Karst
  • Patent number: 8509890
    Abstract: Various embodiments of the present invention are directed to, or are for use with, an implantable system including a lead having multiple electrodes implantable in a patient's left ventricular (LV) chamber. In accordance with an embodiment, the patients LV chamber is paced at first and second sites within the LV chamber using a programmed LV1-LV2 delay, wherein the LV1-LV2 delay is a programmed delay between when first and second pacing pulses are to be delivered respectively at the first and second sites within the LV chamber. Evoked responses to the first and second pacing pulses are monitored for, and one or more LV pacing parameter is/are adjusted and/or one or more backup pulse is/are delivered based on results of the monitoring.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: August 13, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Allen J. Keel, Kyungmoo Ryu, Stuart Rosenberg
  • Publication number: 20130197594
    Abstract: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: August 1, 2013
    Applicant: Cardiac Pacemakers, Inc.
    Inventors: Aaron R. McCabe, Imad Libbus, Yi Zhang, Paul A. Haefner, Alok S. Sathaye, Anthony V. Caparso, M. Jason Brooke
  • Publication number: 20130184774
    Abstract: Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, a catheter arrangement includes a fixation mechanism to attach the catheter arrangement to heart tissue, individually-addressable electrodes for providing pacing signals to the heart tissue, and an elongated structure that supports the fixation mechanism and the electrodes.
    Type: Application
    Filed: November 29, 2012
    Publication date: July 18, 2013
    Inventors: Qingsheng Zhu, Daniel Felipe Ortega
  • Patent number: 8489207
    Abstract: A medical device having a unit in communication with ancillary components wherein the unit and the ancillary components each have a sensory output through which communication with a user of the medical device may be accomplished and to which the user's attention directed. In one aspect, the medical device is an AED unit with associated pads, which are an ancillary component electrically connected to the AED unit. In this illustrative example, the unit has a unit sensory output (e.g., a speaker or a display), and the pads, and/or their associated packaging, have an ancillary sensory output (e.g. a speaker or display). Programming in the AED unit controls output to the sensory outputs such that the user's attention is directed between the unit and the ancillary components.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: July 16, 2013
    Inventors: Gintaras A Vaisnys, Glenn W. Laub, Giovanni C Meier
  • Patent number: 8478414
    Abstract: Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: July 2, 2013
    Assignee: CVRx, Inc.
    Inventors: Robert S. Kieval, Martin Rossing
  • Publication number: 20130150910
    Abstract: An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
    Type: Application
    Filed: February 4, 2013
    Publication date: June 13, 2013
    Applicant: Cardiac Pacemakers, Inc.
    Inventor: Cardiac Pacemakers, Inc.
  • Patent number: 8457734
    Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: June 4, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, Anthony V. Caparso, Kristofer J. James, Stephen Ruble, Weiying Zhao
  • Patent number: 8437848
    Abstract: A new pacemaker apparatus for treating the physiological electric conduction of the heart that includes a conduction abnormality in a ventricle. The pacemaker includes a pulse generator and a pacing electrode located in the heart, the pulse generator providing pacing signals to the pacing electrode. The pacemaker further includes a signal generation circuit that generates electrical signals from heart-related feedback signals that indicate that the pacing electrode is delivering the pacing signals in a region at or near the His bundle of the heart. The combination of the pulse generator and the signal generation circuit indicates that the pacing electrode is delivering the pacing signals in the region, at or near the His bundle of the heart, to electrically bypass the conduction abnormality of the heart in the ventricle.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: May 7, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Daniel Felipe Ortega, Alberto German Giniger
  • Patent number: 8428715
    Abstract: Treating the physiological electric conduction of the heart includes methods that involve guiding an electrode to a location, near the His bundle of the heart, that is determined by pacing the heart and sensing signals in response thereto, and electrically bypassing a conduction abnormality of the heart by presenting extrinsic pacing signals to the location near the His bundle of the heart. The pacing electrode may then be fixed at the location, near the His bundle, to provide subsequent pacing of the heart such that the subsequent pacing exhibits electrical bypassing of the conduction abnormality.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: April 23, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Daniel Felipe Ortega, Alberto German Giniger
  • Publication number: 20130096639
    Abstract: A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activation, and applying a non-excitatory electric field having a given duration, at a delay after the activation, to the portion, which causes the force of contraction to be increased by a least 5%.
    Type: Application
    Filed: October 29, 2012
    Publication date: April 18, 2013
    Applicant: Impulse Dynamics NV
    Inventor: Impulse Dynamics N.V.
  • Patent number: 8423140
    Abstract: A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: April 16, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Barun Maskara, Lili Liu, Guy Alvarez, Scott A. Meyer
  • Patent number: 8417336
    Abstract: A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodynamic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: April 9, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Barun Maskara, Lili Liu, Guy Alvarez, Scott A. Meyer
  • Patent number: 8406876
    Abstract: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: March 26, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Aaron R. McCabe, Imad Libbus, Yi Zhang, Paul A. Haefner, Alok S. Sathaye, Anthony V. Caparso, M. Jason Brooke
  • Patent number: 8406878
    Abstract: A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: March 26, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Qingsheng Zhu, Joseph M. Pastore, Rodney W. Salo
  • Patent number: 8391975
    Abstract: A method for use in an implantable medical device system, comprising: selecting a first sensing electrode operatively disposed in a first heart chamber; setting a first sensing window corresponding to cardiac electrical events occurring in a second heart chamber; enabling a first sense amplifier coupled to the first sensing electrode during the first sensing window; sensing a first signal corresponding to cardiac electrical events occurring in the second heart chamber during the first sensing window using the first sensing electrode; and transmitting the first signal from an implantable medical device to an external monitor.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: March 5, 2013
    Assignee: Medtronic, Inc.
    Inventor: Giorgio Corbucci