Heart Rate Regulating (e.g., Pacing) Patents (Class 607/9)
  • Patent number: 11406829
    Abstract: A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 9, 2022
    Assignee: BackBeat Medical, LLC
    Inventors: Robert S. Schwartz, Robert A. Van Tassel
  • Patent number: 11400296
    Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 2, 2022
    Assignee: Medtronic, Inc.
    Inventors: Zhongping Yang, Thomas A. Anderson, Brian P. Colin, William J. Clemens, Subham Ghosh, Jeffrey M. Gillberg, Maurice T. I. Verbeek, Toine Camps, Lilian Kornet, Berthold Stegemann, Jean Rutten
  • Patent number: 11389658
    Abstract: Methods and systems for treating cardiac malfunction are disclosed, which according to an embodiment, may involve delivering a stimulation pattern of stimulation pulses to at least one cardiac chamber of a heart, with at least one of the stimulation pulses having a first stimulation setting configured to reduce at least one of end systolic volume (ESV) and end diastolic volume (EDV) in the heart and at least one of the stimulation pulses having a second stimulation setting different from the first stimulation setting, and with the stimulation pattern being configured to reduce the at least one of end systolic volume (ESV) and end diastolic volume (EDV) by at least 5% and maintain the at least one of end systolic volume (ESV) and end diastolic volume (EDV) on average at such reduced volume for a time period of at least one hour.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: July 19, 2022
    Assignee: BackBeat Medical, LLC
    Inventors: Yuval Mika, Darren Sherman, Daniel Burkhoff
  • Patent number: 11389656
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: July 19, 2022
    Assignees: SORIN CRM SAS, UNIVERSI IÉ DE RENNES 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Patent number: 11390847
    Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: July 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Patent number: 11380055
    Abstract: A system for computational localization of fibrillation sources is provided. In some implementations, the system performs operations comprising generating a representation of electrical activation of a patient's heart and comparing, based on correlation, the generated representation against one or more stored representations of hearts to identify at least one matched representation of a heart. The operations can further comprise generating, based on the at least one matched representation, a computational model for the patient's heart, wherein the computational model includes an illustration of one or more fibrillation sources in the patient's heart. Additionally, the operations can comprise displaying, via a user interface, at least a portion of the computational model. Related systems, methods, and articles of manufacture are also described.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: July 5, 2022
    Assignee: The Regents of the University of California
    Inventors: David E. Krummen, Andrew D. McCulloch, Christopher T. Villongco, Gordon Ho
  • Patent number: 11381450
    Abstract: Systems, methods, and devices, including computer-readable media, for managing operation of devices in complex systems and changing environments. In some implementations, a server system stores data indicating management plans for each of a plurality of different devices, each management plan indicating a device-specific set of program states for programs in a predetermined set of programs. The server system alters the management plans and enforces interdependence of the programs, and the server system generates a customized instruction that alters operation of the device according to the device-specific set of program states assigned in the altered management plan for the device. The server system causes each device to perform one or more operations of the device determined according to the device-specific set of program states assigned in the altered management plan for the device.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: July 5, 2022
    Assignee: VigNet Incorporated
    Inventors: Praduman Jain, Dave Klein, Neeta Jain, Yue Cao
  • Patent number: 11357972
    Abstract: Methods and systems for alleviating disorders and complications associated with autonomic nervous system dysfunction. The approach generally includes measuring heart rate signals from a subject to measure heart rate variability and determine a heart rate variability threshold, determining that the subject is experiencing autonomic nervous system dysfunction, and alerting the subject to stimulate the auricular branch of the vagus nerve with an ear device.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 14, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Sunny Po, Benjamin Scherlag, Stavros Stavrakis, Paul Garabelli, David Albert
  • Patent number: 11338143
    Abstract: A stimulation control unit that outputs a stimulation signal for reducing a myocardial workload to an electrode for stimulation inserted in a blood vessel running in the vicinity of the vagus nerve of a patient in order to stimulate the vagus nerve; a detecting unit that detects first biological information and second biological information of the patient; a setting unit that sets threshold information for determining a normal range of the first biological information and second biological information; and a determining unit that determines whether or not values of the detected first biological information and second biological information are within the normal range determined in the threshold information; where the stimulation control unit adjusts the intensity of the stimulation signal such that the values of the first biological information and second biological information are within the normal range, and the value of the second biological information is reduced by a predetermined ratio or more as compar
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: May 24, 2022
    Assignee: Neuroceuticals, Inc.
    Inventors: Kenji Sunagawa, Shinya Miike, Keita Saku
  • Patent number: 11318310
    Abstract: Electrical stimulation, including high frequency stimulation, for altering autonomic functions, and associated systems and methods are disclosed. A representative method includes directing an electrical signal to a target tissue at (a) a ventral region of the patient's spinal canal, (b) a sympathetic chain structure, or (c) both (a) and (b), at a frequency in a range from 1 kHz to 100 kHz, and an amplitude that does not generate an objectionable, patient-detectable sensation.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: May 3, 2022
    Assignee: Nevro Corp.
    Inventor: Kerry Bradley
  • Patent number: 11311733
    Abstract: Methods and systems are provided for a rate adaptive bi-ventricular fusion pacing. The methods and systems deliver a first pulse at a left ventricular (LV) lead and a second pulse at a right ventricular (RV) lead based on a paced atrio-ventricular (AV) delay. The first pulse timed to be delivered concurrently with an intrinsic ventricular conduction. The methods and systems further repeat the delivery of the first pulse and the second pulse for a predetermined number of cycles. Additionally, the methods and systems measure an intrinsic AV conduction interval, and adjust the paced AV delay based on the intrinsic AV conduction interval and a negative hysteresis delta.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 26, 2022
    Assignee: PACESETTER, INC.
    Inventor: Brian Wisnoskey
  • Patent number: 11304803
    Abstract: A method for implanting a replacement heart valve within a diseased valve includes accessing a patient's heart by piercing a myocardium, advancing a guidewire into the patient's heart, and installing an access device in a wall of the heart. The access device preferably has at least one valve mechanism. A valve delivery device is advanced over the guidewire and through the access device. The valve delivery device has a replacement heart valve disposed along a distal end portion thereof. The replacement heart valve preferably includes an outer support structure and a leaflet valve disposed within the outer support structure. The replacement heart valve is radially expanded within the diseased valve. During implantation, the outer support structure conforms to a diameter of the diseased valve and the leaflet valve expands to a fixed size having a diameter smaller than the diameter of the diseased valve.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: April 19, 2022
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventor: Christoph Hans Huber
  • Patent number: 11298547
    Abstract: A medical device is configured to generate fluid status signal data of a patient by determining impedance metrics from an impedance signal, determining cardiac electrical signal amplitudes from a cardiac electrical signal and determining a calibration relationship between the impedance metrics and cardiac electrical signal amplitudes. The medical device generates a fluid status signal data by adjusting cardiac electrical signal amplitudes according to the determined calibration relationship. The fluid status signal data may be displayed or monitored for detecting a change in the patient's fluid status.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: April 12, 2022
    Assignee: Medtronic, Inc.
    Inventors: Zhendong Song, Todd M. Zielinski, Brian B. Lee
  • Patent number: 11291850
    Abstract: An external wearable medical device includes an electrode to detect patient cardiac activity; a therapy electrode to provide a therapy in response to detecting an arrhythmia event; a GUI display comprising a caregiver interface and a patient interface; and a processor configured to provide, to the caregiver interface, a first set of information that includes information for operating the device in conjunction with the patient and an alert history of the device including an indication of one or more detected arrhythmia events, provide, to the patient interface, a second set of information that includes information for allowing the patient to cause the device to suspend providing the therapy and a direction to the patient to contact a caregiver responsive to detecting an event affecting at least one of the device and the patient, and responsive to detecting the event, automatically transmitting a notification of the event to an external entity.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: April 5, 2022
    Assignee: ZOLL MEDICAL CORPORATION
    Inventors: Trisha A. Pavel, John G. Clark, Edward J. Donnelly, Thomas E. Kaib
  • Patent number: 11291834
    Abstract: A subcutaneous implantable medical device and method (SIMD) provided. A pulse generator (PG) is configured to be positioned subcutaneously within a lateral region of a chest of a patient. The PG has a housing that includes a PG electrode. The PG has an electronics module. An elongated lead is electrically coupled to the pulse generator. The elongated lead includes a first electrode that is configured to be positioned along a first parasternal region proximate a sternum of the patient and a second electrode that is configured to be positioned at an anterior region of the patient. The first and second electrodes are coupled to be electrically common with one another. The electronics module is configured to provide electrical shocks for antiarrhythmic therapy along at least one shocking vector between the PG electrode and the first and second electrodes.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: April 5, 2022
    Assignee: Pacesetter, Inc.
    Inventors: Xiaoyi Min, Kyungmoo Ryu, Keith Victorine, Stuart Rosenberg, Gene A. Bornzin
  • Patent number: 11273307
    Abstract: A method for delivering energy as a function of degree coupling may utilize an external unit configured for location external to a body of a subject and at least one processor associated with the implant unit and configured for electrical communication with a power source. The method may determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and regulate delivery of power to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 15, 2022
    Assignee: NYXOAH SA
    Inventors: Adi Mashiach, Oliver Scholz
  • Patent number: 11259732
    Abstract: A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: March 1, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jordi Parramon, Emanuel Feldman, Jess Weiqian Shi
  • Patent number: 11260233
    Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: March 1, 2022
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Markus Meyer
  • Patent number: 11253709
    Abstract: An electrode lead for the coronary sinus, with a lead body that has a distal section for insertion into the coronary sinus, and at least one electrode to make contact with body tissue, the at least one electrode being arranged on the distal section of the lead body. The electrode lead has a fixation device that can be extended out of the lead body to fix the electrode lead in a blood vessel.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: February 22, 2022
    Assignee: Biotronik SE & Co. KG
    Inventors: Detmar Jadwizak, Dajana Kaiser, Carsten Fruendt, Gordon Hillebrand
  • Patent number: 11247061
    Abstract: In some examples, medical device systems that deliver anti-tachyarrhythmia shock(s) (e.g., defibrillation shock(s)) to a heart of a patient in coordination with the respiration of the patient. In one example, a medical device system including therapy generation circuitry configured to generate a defibrillation shock. The medical device system also includes processing circuitry configured to identify a time at which a respiratory volume of a lung of a patient is at approximately end tidal volume or less; and control the therapy generation circuitry to deliver the defibrillation shock to a heart of the patient at the time that the respiratory volume of the lung of a patient is at the approximately end tidal volume or less.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: February 15, 2022
    Assignee: Medtronic, Inc.
    Inventors: Amy E. Thompson-Nauman, Jeffrey D. Wilkinson, Darrell J. Swenson
  • Patent number: 11235158
    Abstract: Systems and methods are provided for detecting arrhythmias in cardiac activity is provided. The systems and methods include measuring conduction delays between an atria (A) and multiple left ventricular (LV) electrodes to obtain multiple intrinsic A/LV intervals, measuring conduction delays between a right ventricular (RV) and the multiple LV electrodes to obtain multiple intrinsic VV intervals. The systems and methods include calculating a first atrial ventricular (AV) delay based on at least one of the intrinsic A/LV intervals, and calculating a second AV delay based on at least one of the intrinsic VV intervals. The systems and methods include selecting a biventricular (BiV) pacing mode or an LV only pacing mode based on a relation between the first and second AV delays, and delivering a pacing therapy based on the selecting operation.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: February 1, 2022
    Assignee: PACESETTER, INC.
    Inventors: Jan O. Mangual-Soto, Nima Badie, Luke C. McSpadden, Jong Gill, Louis-Philippe Richer
  • Patent number: 11235159
    Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: February 1, 2022
    Assignee: Medtronic, Inc.
    Inventors: Zhongping Yang, Thomas A. Anderson, Brian P. Colin, William J. Clemens, Subham Ghosh, Jeffrey M. Gillberg, Maurice T. I. Verbeek, Toine Camps, Lilian Kornet, Berthold Stegemann, Jean Rutten
  • Patent number: 11229795
    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 25, 2022
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre Sambelashvili, Thomas J. Mullen, Todd J. Sheldon
  • Patent number: 11224752
    Abstract: Systems and methods for pacing cardiac conductive tissue are described. In an embodiment, a medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses. A sensing circuit senses an atrial activation. A control circuit detects a retrograde atrial conduction timing, such as a His-to-atrial interval between the HBP pulse and the sensed atrial activation in response to the HBP pulse, and verifies capture status using the determined retrograded atrial conduction timing. Based on the capture status, the control circuit determines a HBP threshold, and the electrostimulation circuit delivers HBP pulses in accordance with the determined HBP threshold.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: January 18, 2022
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: David Arthur Casavant
  • Patent number: 11219774
    Abstract: A computer implemented method and device for providing dual chamber sensing with a single chamber leadless implantable medical device (LIMD) are provided. The method is under control of one or more processors in the LIMD configured with specific executable instructions. The method obtains a far field (FF) cardiac activity (CA) signals for activity in a remote chamber of a heart and compares the far field CA signals to a P-wave template to identify an event of interest associated with the remote chamber. The method sets an atrial-ventricular (AV) delay based on the P-wave identified and delivers pacing pulses at a pacing site of interest to a local chamber based on the AV delay.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: January 11, 2022
    Assignee: Pacesetter, Inc.
    Inventors: Gene A. Bornzin, Nima Badie, Chunlan Jiang, David Ligon
  • Patent number: 11213676
    Abstract: An implantable medical device delivery system includes a delivery catheter including an elongated body with a first portion defining a first lumen and a second portion defining a second lumen. An angle is defined between a first axis and a second axis defined by the first and second portions, respectively. The second axis points toward the left ventricular (LV) apex of the patient's heart when the first axis points into the CS. The first portion or an elongated element may extend into the CS to anchor the delivery catheter to the orientation of the CS.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: January 4, 2022
    Assignee: Medtronic, Inc.
    Inventors: Andrea J. Asleson, Zhongping Yang, Ruth N. Klepfer
  • Patent number: 11207528
    Abstract: Systems and methods for dynamically controlling HBP delivery based on patient AV conduction status are disclosed. An exemplary medical system includes an electrostimulation circuit to generate HBP pulses to stimulate a His bundle or a bundle branch of the heart. An AV conduction monitor circuit continuously or periodically assesses AV conduction status, and detects an indication of presence or absence of AV conduction abnormality. If an AV conduction abnormality is indicated, a control circuit may control the electrostimulation circuit to deliver the HBP pulses. Ventricular backup pacing may be delivered if HBP fails to capture and elicit ventricular activation. When the AV conduction become normal, the control circuit may withhold HBP delivery and promote patient intrinsic ventricular activation.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: December 28, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David J. Ternes, Deepa Mahajan
  • Patent number: 11207524
    Abstract: Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: December 28, 2021
    Assignee: MIROWSKI FAMILY VENTURES, LLC
    Inventor: Morton M. Mower
  • Patent number: 11207033
    Abstract: The invention relates to a determination system (1) for determining a heart failure risk for a subject (4). The determination system is adapted to provide a cardiogram selected from a group consisting of a ballistocardiogram, a seismocardiogram and an impedance cardiogram of the subject, to detect at least one of a presence of a postextrasystolic potentiation (PESP) and a disturbed force-frequency relation (FFR) based on the provided cardiogram and to determine the heart failure risk based on this detection. By using the detection of the presence of the PESP and/or of a disturbed FFR, the heart failure risk can be reliably determined. In particular, it can be determined that the heart failure risk is relatively large, if a PESP is not present and/or if the FFR is disturbed.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: December 28, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Ronaldus Maria Aarts
  • Patent number: 11207523
    Abstract: Systems and methods for pacing cardiac conductive tissue are described. An exemplary system includes an electrostimulation circuit that may generate HBP pulses to stimulate patient physiologic conduction pathway, such as a His bundle or a bundle branch. The system includes an arrhythmia detector to detect an atrial tachyarrhythmia (AT) with intermittent ventricular conduction. A control circuit may sense ventricular activation and, in response to the detected AT indication, determine or update a His-bundle pacing (HBP) configuration. The HBP may be recursively updated on a beat-by-beat basis using the sensed ventricular activation. The electrostimulation circuit may deliver HBP according to the determined or adjusted HBP configuration to regularize ventricular rate during AT.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: December 28, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David J. Ternes, Deepa Mahajan, Keith L. Herrmann
  • Patent number: 11202904
    Abstract: A method for positioning an electrode array of a neuromodulation catheter at a target circumferential position along a posterior wall of a blood vessel. The method includes advancing the catheter to a target longitudinal position within the blood vessel and positioning the array within the blood vessel so as to minimize interference by CRM leads or coils in the blood vessel during therapeutic delivery of energy using the array.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: December 21, 2021
    Assignee: NuXcel Limited
    Inventor: Stephen C Masson
  • Patent number: 11198010
    Abstract: This document discusses, among other things, systems and methods to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, and alternate the first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay. Physiologic information can be received from the patient, and one of the first or second pacing period for delivery to the patient can be determined using the received physiologic information.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 14, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Stephen J. Hahn, Pramodsingh Hirasingh Thakur, Qi An, Viktoria A. Averina, Krzysztof Z. Siejko, Ramesh Wariar
  • Patent number: 11191446
    Abstract: An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: December 7, 2021
    Assignee: BLOSSOM INNOVATIONS, LLC
    Inventors: Joe Ting, Tania To, Vincent Zuo, James Wright, Ben Apollonio, Charles Holland Dresser
  • Patent number: 11191951
    Abstract: A device for electrical stimulation of one or more components of the periodontal complex and surrounding tissue of a tooth, for uses such as reducing orthodontic pain and encouraging tooth movement, has electrodes of a rigid, electrically conductive material in a fixed spatial relationship configured for application to oral mucosa and attached gingiva adjacent to, and along a periodontal ligament of, a root structure of a single tooth. An electrical circuit is configured for electrical connection to the at least two electrodes. The electrical circuit has an output providing a subsensory electrical stimulus comprising a waveform in accordance with predetermined stimulation parameters. After the electrodes are applied to the oral mucosa and attached gingiva adjacent to, and along the periodontal ligament of, a root structure of the tooth, a switch, when activated, activates the electrical circuit to output the electrical stimulus through the at least two electrodes.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: December 7, 2021
    Inventor: Cosmo Haralambidis
  • Patent number: 11185700
    Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 30, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David J. Ternes, Yinghong Yu, Jason Humphrey, David L. Perschbacher, Michael James Dufresne, Adam MacEwen, Keith L. Herrmann
  • Patent number: 11177891
    Abstract: A communication device that includes an antenna including a first electrode and a second electrode, at least one of the first electrode or the second electrode including a plurality of segmented electrodes. The communication device further includes a communication circuit, coupled to the antenna, that performs a transmission operation and a reception operation of transmission data between a device and the communication circuit based on a communication protocol that includes a plurality of communication stages. The communication device further includes a switch that switches whether or not each of the plurality of segmented electrodes is to be coupled to the communication circuit and a controller that changes an effective electrode area of at least one of the first electrode or the second electrode by the switch, based on at least one of the operations of the communication circuit, a type of the transmission data, or the communication stages.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: November 16, 2021
    Assignee: SONY SEMICONDUCTOR SOLUTIONS CORPORATION
    Inventors: Keiji Akiyama, Fumihiro Nishiyama
  • Patent number: 11172885
    Abstract: A medical device including an electric measurement circuit, in which are connected at least two sensors the impedance of which varies as a function of a sensed physical parameter, a source of electrical power for powering the electric measurement circuit, an antenna for emitting an electromagnetic field as a function of the impedance of the electric measurement circuit, each of the sensors being associated with a switch for short circuiting the sensor in the measurement circuit, the medical device further including a system for controlling the switches in order successively to command the opening or closing of the switches in determined configurations. The medical device may notably be able to be applied to the human body or implanted in the human body.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: November 16, 2021
    Assignees: Centre National de la Recherche Scientifique, Ecole Polytechnique, Ecole Normale Superieure de Cachan
    Inventors: Abdul Barakat, Franz Bozsak, Yvan Eric Bonnassieux, Bruno Le Pioufle, Olivier Francais, Bruno Carreel
  • Patent number: 11160985
    Abstract: Techniques are described in this disclosure for delivering electrical stimulation therapy to a patient over multiple channels, with independent rate control for each channel, using a single stimulation generator. In one example, the disclosure describes a method for delivering electrical stimulation therapy to a patient that includes delivering first electrical stimulation pulses at a first programmed rate on a first channel using a stimulation generator, and delivering second electrical stimulation pulses at a second programmed rate on a second channel using the stimulation generator, the second programmed rate being different than the first programmed rate, and the second programmed rate being independent of the first programmed rate.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 2, 2021
    Assignee: Medtronic, Inc.
    Inventor: Todd A. Kallmyer
  • Patent number: 11141594
    Abstract: This document discusses, among other things, systems and methods to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, to alternate first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, and to determine an increased pacing rate for the first pacing waveform during the first pacing period using the first AV delay, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 12, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Stephen J. Hahn, Pramodsingh Hirasingh Thakur, Qi An, Viktoria A. Averina, Krzysztof Z. Siejko, Ramesh Wariar
  • Patent number: 11135434
    Abstract: The present disclosure provides systems and methods for protection circuitry for an implantable pulse generator (IPG) of a neurostimulation system. The protection circuitry is coupled to an IPG ground, a plurality of electrodes, and an IPG case, and operable to protect IPG stimulation and sensing circuitry from damage during electrostatic discharge and cardiac defibrillation, and to mitigate unintended stimulation during electromagnetic interference. The protection circuitry includes an IPG ground connection, a plurality of protection Zener diodes, wherein one of the protection Zener diodes is electrically coupled between the IPG case and a float Zener diode, and wherein the remaining protection Zener diodes are electrically coupled between the plurality of electrodes and the float Zener diode, and the float Zener diode electrically coupled between the plurality of protection Zener diodes and the IPG ground.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 5, 2021
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventor: Steven Boor
  • Patent number: 11129988
    Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: September 28, 2021
    Assignee: Medtronic, Inc.
    Inventors: Xiaohong Zhou, John Edward Burnes, Lilian Kornet, Richard N.M. Cornelussen
  • Patent number: 11123566
    Abstract: In some examples, a system can be used for delivering cardiac resynchronization therapy (CRT). The system may include a pacing device configured to be implanted within a patient. The pacing device can include a plurality of electrodes, signal generation circuitry configured to deliver ventricular pacing via the plurality of electrodes, and a sensor configured to produce a signal that indicates mechanical activity of the heart. Processing circuitry can be configured to identify one or more features of a cardiac contraction within the signal, and determine whether the contraction was a fusion beat based on the one or more features.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: September 21, 2021
    Assignee: Medtronic, Inc.
    Inventors: Robert W. Stadler, Richard Cornelussen, Berthold Stegemann
  • Patent number: 11103709
    Abstract: Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit that may generate His-bundle pacing (HBP) pulses for delivery at or near the His bundle. In response to the delivery of the HBP pulse, the system senses a near-field cardiac activity representative of excitation of a para-Hisian myocardial tissue, and a far-field cardiac activity representative of excitation of the His bundle and a ventricle. The system classifies a tissue response to HBP into one of a plurality of capture types based on the sensed near-field and far-field cardiac activities. The system includes a control circuit to adjust one or more stimulation parameters based on the classified capture type. The electrostimulation circuit generates and delivers the HBP pulses according to the adjusted stimulation parameters to excite the His bundle.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: August 31, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan Charles Shuros, David Arthur Casavant, Ramesh Wariar
  • Patent number: 11096969
    Abstract: The present invention aims to provide a method which has not been established yet and which is useful for achieving long-term and fundamental cure of a necrotic cardiac tissue region to allow recovery of functionality of the heart. The present invention provides an injectable composition for treatment of a cardiac disease, the composition comprising fibroblasts, wherein the fibroblasts contain CD106-positive fibroblasts, preferably contain CD90-positive fibroblasts, and the fibroblasts do not form colonies.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: August 24, 2021
    Assignee: Metcela, Inc.
    Inventor: Takahiro Iwamiya
  • Patent number: 11083894
    Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: August 10, 2021
    Assignee: BackBeat Medical, LLC
    Inventors: Howard Levin, Mark Gelfand
  • Patent number: 11083898
    Abstract: This document discusses, among other things, a modular antitachyarrhythmia therapy system. In an example, a modular antitachyarrhythmia system includes at least two separate modules that coordinate delivery an antitachyarrhythmia therapy, such as defibrillation therapy. In another example, a modular antitachyarrhythmia therapy system includes a sensing module, an analysis module, and a therapy module.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: August 10, 2021
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Joseph M. Smith, Richard Milon Dujmovic, Jr.
  • Patent number: 11077306
    Abstract: In some examples, controlling delivery of cardiac resynchronization therapy (CRT) includes storing, in a memory of an implantable medical device system and in association with each of a plurality of heart rates, at least one respective value for an interval between an atrial event and a ventricular event. Processing circuitry of the implantable medical device system may determine a heart rate of a patient and select one of the stored values for the interval between the atrial event and the ventricular event associated with the determined heart rate. The processing circuitry may further determine whether to control therapy delivery circuitry of the implantable medical device system to deliver fusion pacing or biventricular pacing, based on the selected one of the stored values for the interval between the atrial event and the ventricular event.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: August 3, 2021
    Assignee: Medtronic, Inc.
    Inventors: Nathan A. Grenz, Thomas J. Mullen
  • Patent number: 11076766
    Abstract: A system can include a wearable device that obtains real-time physiological data and activity data from a user and transmits that data to another device. A computing device can receive HRV and activity data and determine whether the user's autonomic nervous system is in a predominantly sympathetic or parasympathetic state. For example, the determination can include comparing an average variance in a portion of the HRV data with a threshold value. In response to determining that the user's autonomic nervous system is in a sympathetic state, the device can perform an action.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: August 3, 2021
    Assignee: BEIJING SHUNYUAN KAIHUA TECHNOLOGY LIMITED
    Inventors: Artem Galeev, Yan Vule
  • Patent number: 11071870
    Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to gather information during a cardiac cycle and to identify a cardiac interval based at least on part on the gathered information. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified cardiac interval.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: July 27, 2021
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Jeffrey E. Stahmann, Keith R. Maile, Krzysztof Z. Siejko, Allan Charles Shuros
  • Patent number: 11052260
    Abstract: An optoelectronic electrode element includes an electrode module (40) having at least a first and second electrodes (41, 42) each having an electrode surface (41s, 42s). An an optoelectronic module (20) is provided and having a photovoltaic cell (21a) suitable for transforming optical energy into electrical energy. A feeding fibre optic (31a) is also provided. A coupling module (10) is provided and having a circuit receiving portion (12) for inserting, positioning, and rigidly fixing the optoelectronic module (20) to the coupling module (10); and a feeding fibre cavity (11a) for inserting and coupling the feeding fibre optic to bring it in optimal optical communication with the photovoltaic cell. The coupling module (10) is coupled directly to a fixing area of the electrode module (40), such that the photovoltaic cell be in electrical contact with the first and second electrodes (41, 42).
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: July 6, 2021
    Assignee: SYNERGIA MEDICAL
    Inventors: Pascal Doguet, Marie Dautrebande, Carmen Godfraind