Heart Rate Regulating (e.g., Pacing) Patents (Class 607/9)
  • Patent number: 11925807
    Abstract: Pacemaker-initiated atrial fibrillation during competitive atrial pacing is a common arrhythmia with potentially serious consequences The novel pacing method proposes a novel way to automatically detect and diagnose competitive atrial pacing, and to deliver an intervention via a pacing stimulus in the atrium simultaneously with delivering a pacing stimulus in the ventricle, and doing this after a longer waiting period. By doing this, potentially hazardous scenarios causing atrial fibrillation in competitive atrial pacing are avoided, while the rhythm regularity and the synchrony between the upper and lower chambers of the heart are maintained. At the same time, the vicious cycle of retrograde conduction from the ventricle to the atrium—the culprit of the problem—is terminated and not allowed to reoccur for several subsequent cardiac cycles, thereby preventing the extended propagation of repetitive non-reentrant ventriculo-atrial synchrony.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: March 12, 2024
    Inventor: Michael V Orlov
  • Patent number: 11925812
    Abstract: The present technology generally includes devices, systems, and methods for providing electrical stimulation to the left ventricle of a human heart in a patient suffering from Left Bundle Branch Block (LBBB). In particular, the present technology includes an implantable receiver-stimulator and an implantable controller-transmitter for leadless electrical stimulation of the heart. The receiver-stimulator can include one or more sensors capable of detecting the electrical conduction of the heart and the receiver-stimulator can be configured to pace the stimulation of the left ventricle based off the sensed electrical conduction to achieve synchronization of the left and right ventricles.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: March 12, 2024
    Assignee: EBR SYSTEMS, INC.
    Inventors: Steven Kim, Nathaniel Parker Willis
  • Patent number: 11918814
    Abstract: Systems and methods for pacing cardiac conductive tissue are described. An embodiment of a medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to stimulate a His bundle, and a cardiac event detector to detect a His-bundle activity within a time window following an atrial activity. The cardiac event detector may use a cross-chamber blanking, or an adjustable His-bundle sensing threshold, to avoid or reduce over-sensing of far-field atrial activity and inappropriate inhibition of HBP therapy. The electrostimulation circuit may deliver HBP in the presence of the His-bundle activity. The system may further recognize the detected His-bundle activity as either a FFPW or a valid inhibitory event, and deliver or withhold HBP therapy based on the recognition of the His-bundle activity.
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: March 5, 2024
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David Arthur Casavant, David L. Perschbacher, Deepa Mahajan
  • Patent number: 11911168
    Abstract: Systems and methods are described herein for determining whether cardiac conduction system pacing therapy may be beneficial and/or determining how proximal or distal a cardiac conduction system block may be using external cardiac signals. To do so, one or more left-sided metrics of electrical heterogeneity information may be generated based on left-sided surrogate cardiac electrical measured using a plurality of left external electrodes.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: February 27, 2024
    Assignee: Medtronic, Inc.
    Inventor: Subham Ghosh
  • Patent number: 11916256
    Abstract: In some examples, an assembly for a medical device. The assembly includes a first electrode comprising a first conductive tab, and a first current collector; a second electrode including a second conductive tab, a second current collector, a third current collector, and at least one connector connecting the second current collector to the third current collector, wherein the second current collector and the third current collector are folded over each other about the at least one connector, wherein the second conductive tab is coupled to the second current collector, and wherein the third current collector is electrically coupled to second conductive tab via the at least one connector and the second current collector; and a foil package being sealed over the first conductive tab and the second conductive tab to partially enclose the first electrode and second electrode.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: February 27, 2024
    Assignee: Medtronic, Inc.
    Inventors: Joseph J. Viavattine, Erik J. Hovland
  • Patent number: 11908299
    Abstract: System and methods for delivering defibrillator incident information to a PSAP in real-time during emergency use of an AED are described. Such information is utilized by a telecommunicator at a PSAP to provide better guidance to volunteer caregivers during potential cardiac arrest incidents. In another aspect the AED's current instruction state and optionally the time in that state is provided to the PSAP.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: February 20, 2024
    Assignee: Avive Solutions, Inc.
    Inventors: Rory M. Beyer, Micah R. Bongberg, Sameer Jafri, Gordon Moseley P. Andrews
  • Patent number: 11890476
    Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: February 6, 2024
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Andrew P. Kramer, William J. Linder, Jeffrey E. Stahmann
  • Patent number: 11883673
    Abstract: In some examples, an implantable medical device includes a battery, an electronics module electrically connected to the battery, and an elongated housing comprising a side wall positioned between the battery and an end cap, wherein the electronics module is positioned within the elongated housing between the battery and the end cap. The implantable medical device also includes an electrical contact assembly comprising a first spring contact and a second spring contact. The electrical contact assembly of the implantable medical device is positioned within the elongated housing between the electronics module and the battery or the end cap.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: January 30, 2024
    Assignee: Medtronic, Inc.
    Inventors: Andrew J. Ries, Chunho Kim, Mark E. Henschel, Robert A. Munoz, Christopher T. Kinsey, Jeffrey S. Voss
  • Patent number: 11883138
    Abstract: A method of determining one or more diagnostic metrics to assess a blood vessel using intravascular data includes: sampling a sensor of an intravascular data collection probe disposed in the blood vessel during a pullback of the intravascular data collection probe through the blood vessel to obtain sampled distal pressure (Pd) values; receiving, at an intravascular data processing system, the sampled distal pressure (Pd) values and proximal pressure (Pa) values; determining sets of Pd/Pa ratios, each set including Pd/Pa ratios that are determined through an entirety of one heart cycle; determining minimum Pd/Pa ratios, each of which is a minimum within one of the sets of Pd/Pa ratios over the entirety of the corresponding heart cycle; and controlling a display system to generate a plot of a moving average of the minimum Pd/Pa ratios over time during the pullback.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: January 30, 2024
    Assignee: ST. JUDE MEDICAL COORDINATION CENTER BVBA
    Inventor: Johan Svanerudh
  • Patent number: 11883152
    Abstract: Systems and methods for determining a contact angle of a catheter relative to tissue are provided. In one embodiment, a system includes a catheter with three or more electrodes, and a processor circuit in communication with the catheter. The processor circuit controls the three or more electrodes to emit a plurality of electrical voltages and to measure the plurality of electrical voltages. Based on the measured electrical voltages, the processor circuit calculates a first interelectrode impedance and a second interelectrode impedance. The processor circuit calculates, for each of a plurality of hypothetical i.e. model angles, a first hypothetical i.e. model contact force and a second hypothetical i.e. model contact force based on the first and second interelectrode impedances. The processor circuit determines and outputs the contact angle of the catheter based on a comparison of the first and second model contact forces calculated for each of the plurality of model angles.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: January 30, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Oran Gerbat, Shlomo Ben Haim, Asi Elad
  • Patent number: 11883677
    Abstract: An implantable medical device has a therapy module configured to generate a composite pacing pulse including a series of at least two individual pulses. The therapy module is configured to generate the composite pacing pulse by generating a first pulse of the at least two individual pulses by selectively coupling a first portion of a plurality of capacitors to an output signal line and generate a second pulse of the at least two individual pulses by selectively coupling a second portion of the plurality of capacitors to the output signal line.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: January 30, 2024
    Assignee: Medtronic, Inc.
    Inventors: David A Anderson, Mark T. Marshall, Vladimir P. Nikolski, Robert T. Sawchuk, Amy E. Thompson-Nauman, John D. Wahlstrand, Gregory A. Younker
  • Patent number: 11872393
    Abstract: An implantable electrode includes an outer tube, which has a distal end and a proximal end, wherein the implantable electrode is connectable in the region of the proximal end to an active device. At least one electrode line is arranged in the outer tube. At least one electrode pole, which is electrically connected to the at least one electrode line, for electrically contacting tissue surrounding the electrode in the implanted state of the electrode is arranged in the region of the distal end. A stub line for extending the electrical length of the at least one electrode line is connected to the at least one electrode line in the region of the distal end or the proximal end.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 16, 2024
    Assignee: Biotronik SE & Co. KG
    Inventor: Jens Rump
  • Patent number: 11857779
    Abstract: An implantable cardiac defibrillator (ICD) system includes an ICD implanted subcutaneously in a patient, a defibrillation lead having a proximal portion coupled to the ICD and a distal portion having a defibrillation electrode configured to deliver a defibrillation or cardioversion shock to a heart of the patient, and a pacing lead that includes a distal portion having one or more electrodes and a proximal portion coupled to the ICD. The distal portion of the pacing lead is implanted at least partially along a posterior side of a sternum of the patient within the anterior mediastinum. The ICD is configured to provide pacing pulses to the heart of the patient via the pacing lead and provide defibrillation shocks to the patient via the defibrillation lead. As such, the implantable cardiac system provides pacing from the substernal space for an extravascular ICD system.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: January 2, 2024
    Assignee: Medtronic, Inc.
    Inventors: Amy E. Thompson-Nauman, Melissa G. T. Christie, Paul J. DeGroot, Rick D. McVenes, Becky L Dolan
  • Patent number: 11850063
    Abstract: In some examples, processing circuitry of a medical device system determines, for each of a plurality of patient parameters, a difference metric for a current period based on a value of a patient parameter determined for the current period and a value of the patient parameter determined for an immediately preceding period, and determines a score for the current period based on a sum of the difference metrics for at least some of the plurality of patient parameters. The processing circuitry determines a threshold for the current period based on scores determined for N periods that precede the current period, compares the score for the current period to the threshold, and determines whether to generate an alert indicating that an acute cardiac event of the patient, e.g., ventricular tachyarrhythmia, is predicted, and/or deliver a therapy configured to prevent the acute cardiac event, based on the comparison.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: December 26, 2023
    Assignee: Medtronic, Inc.
    Inventor: Xiaohong Zhou
  • Patent number: 11844616
    Abstract: Methods, apparatus, and systems for medical procedures are disclosed herein and include sensing a plurality of tissue electrical potentials at an organ area of an organ, by one or more electrodes on a catheter, determining a number of peak electrical potentials from the plurality of first tissue electrical potentials such that the a peak electrical potential exceeds a potential threshold, determining a first visual characteristic based on the number of peak electrical potential and displaying a rendering of the organ comprising the organ area such that the rendering of the first organ area comprises the first visual characteristic.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: December 19, 2023
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Refael Itah, Aharon Turgeman, Daniel Melby, Gal Hayam, Tal Bar-on
  • Patent number: 11826575
    Abstract: A method for controlling an adaptive pacing therapy that includes utilizing one or more processors to perform measuring an atrial-ventricular (AV) interval corresponding to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event, setting an AV delay based on the AV interval, and measuring an S1 heart sound characteristic of interest (COI) while utilizing the AV delay in connection with delivering a pacing therapy by the IMD. The one or more processors also perform adjusting the AV delay, repeating the measuring, and adjusting to obtain a collection of S1 heart sound COIs and corresponding AV delays, selecting one of the AV delays, that corresponds to a select one of the S1 heart sound COIs, as a resultant AV delay, and managing the pacing therapy, utilized by the IMD, based on the resultant AV delay.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: November 28, 2023
    Assignee: Pacesetter, Inc.
    Inventor: Jan O. Mangual-Soto
  • Patent number: 11819698
    Abstract: A medical device is configured to sense a cardiac signal that includes far field ventricular event signals and determine a ventricular activity metric from the sensed cardiac signal. The ventricular activity metric may be representative of a ventricular rate or an atrioventricular time interval. The medical device is configured to determine an atrioventricular synchrony metric based on the ventricular activity metric and generate an output based on the atrioventricular synchrony metric. The device may include a memory configured to store data corresponding to the atrioventricular synchrony metric.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: November 21, 2023
    Assignee: Medtronic, INC.
    Inventors: Vincent P. Ganion, Yanina Grinberg, Paul R. Solheim
  • Patent number: 11786732
    Abstract: An assessment system is provided for vagus nerve stimulation treatment with a neurostimulator configured to deliver a stimulation signal having a plurality of ON-periods and OFF-periods. The assessment system includes a wand assembly configured to generate a delivery detection signal indicating delivery of the stimulation signal, a lead assembly configured to acquire an ECG signal, and a data acquisition system configured to capture the delivery detection and ECG signals. The assessment system further includes a processor and a non-transitory computer-readable memory storing instructions that, when executed by the processor, cause the assessment system to record the ECG signal over at least one successive pair of ON- and OFF-periods, determine a heart rate dynamic response from the ECG signal, and determine an instantaneous heart rate for each determined R-R interval to determine heart rate dynamics for assessment of autonomic engagement in response to the vagus nerve stimulation treatment.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 17, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Scott R. Stubbs, Scott Mazar, Bruce KenKnight, Badri Amurthur
  • Patent number: 11771359
    Abstract: A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: October 3, 2023
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Roy Urman, Meir Bar-Tal, Yaniv Ben Zrihem, Ziyad Zeidan, Gal Hayam, Stanislav Goldberg, Atul Verma, Yariv Avraham Amos, Richard P. M. Houben
  • Patent number: 11759639
    Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: September 19, 2023
    Assignee: BackBeat Medical, LLC
    Inventors: Howard Levin, Mark Gelfand
  • Patent number: 11759646
    Abstract: A leadless cardiac pacemaker is provided which can include any number of features. In one embodiment, the pacemaker can include a tip electrode, pacing electronics disposed on a p-type substrate in an electronics housing, the pacing electronics being electrically connected to the tip electrode, an energy source disposed in a cell housing, the energy source comprising a negative terminal electrically connected to the cell housing and a positive terminal electrically connected to the pacing electronics, wherein the pacing electronics are configured to drive the tip electrode negative with respect to the cell housing during a stimulation pulse. The pacemaker advantageously allows p-type pacing electronics to drive a tip electrode negative with respect to the can electrode when the can electrode is directly connected to a negative terminal of the cell. Methods of use are also provided.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: September 19, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Kenneth J. Carroll, Alan Ostroff, Peter M. Jacobson
  • Patent number: 11759141
    Abstract: The disclosure relates to a computer-implemented method for monitoring diaphragmatic response to phrenic nerve stimulation. The method comprises receiving in real-time a diaphragmatic CMAP signal. The method comprises computing a baseline value of a characteristic of the CMAP signal. The characteristic represents a diaphragmatic response intensity to a phrenic nerve stimulation. The method comprises determining a threshold value of the characteristic, representing a boundary of values of the characteristic indicative of upcoming diaphragmatic palsy. The determining of the threshold value includes shifting the baseline value. The method comprises receiving in real-time a ECG signal. The method comprises repeating in real-time: detecting a QRS complex in the ECG signal, monitoring the CMAP signal, computing a real-time value of the characteristic, comparing the real-time value to the threshold value, and outputting an alert when the threshold is passed.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: September 19, 2023
    Assignee: CIRCLE SAFE
    Inventors: Frédéric Franceschi, Bertrand Thiery
  • Patent number: 11738199
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: August 29, 2023
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Patent number: 11730414
    Abstract: In one embodiment, a medical system includes respective electrodes for application to a body of a subject and to output a set of respective activation signals in response to electrical activity of a heart of the subject captured over a sequence of heartbeat intervals, and a processor to classify a first heartbeat interval of the set of activation signals as a first morphological template, compute a measure of similarity between a second heartbeat interval of the set of activation signals and the first morphological template, group the second heartbeat interval of the set of activation signals in a first morphological group with the first morphological template responsively to the measure exceeding a predefined threshold, and classify the second heartbeat interval of the set of activation signals as a second morphological template responsively to the measure not exceeding the predefined threshold, and repeat the above, mutatis mutandis, for subsequent heartbeat intervals.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: August 22, 2023
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Jonathan Yarnitsky, Elad Nakar, Lior Greenbaum, Goren Cohn, Amiram Ben Dor
  • Patent number: 11717688
    Abstract: A medical device includes a motion sensor configured to sense a motion signal. The medical device includes a control circuit configured to determine at least one ventricular event metric from the motion signal sensed over multiple of atrial cycles, determine that the ventricular event metric meets atrioventricular block criteria and generate an output in response to determining the atrioventricular block.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: August 8, 2023
    Assignee: Medtronic, Inc.
    Inventors: Michelle M. Galarneau, Vincent P. Ganion, Saul E. Greenhut, Yanina Grinberg, Todd J. Sheldon, Paul R. Solheim, Hyun J. Yoon
  • Patent number: 11697023
    Abstract: A medical device is configured to deliver therapeutic electrical stimulation pulses by generating frequency modulated electrical stimulation pulse signals. The medical device includes a pulse signal source and a modulator. The pulse signal source generates an electrical stimulation pulse signal having a pulse width. The modulator may include a high frequency modulator configured to modulate a frequency of the pulse signal from a starting frequency down to a minimum frequency during the pulse width. The modulator may include a low frequency bias generator to modulate the offset of the pulse signal between a minimum offset and a maximum offset in other examples.
    Type: Grant
    Filed: February 15, 2021
    Date of Patent: July 11, 2023
    Assignee: Medtronic, Inc.
    Inventors: Vladimir P. Nikolski, Melissa G. T. Christie, Mark T. Marshall, Amy E. Thompson-Nauman
  • Patent number: 11690575
    Abstract: A physiological information processing apparatus includes a processor and a memory storing computer-readable instructions. When the instructions are executed by the processor, the physiological information processing apparatus obtains physiological information data indicative of physiological information of a subject, obtains a first parameter associated with a vital sign of the subject based on the physiological information data, displays a first trend graph showing temporal change in the first parameter in a first display area of a display screen of a display, obtains a second parameter associated with an autonomic nerve function of the subject based on the physiological information data, and displays a second trend graph showing temporal change in the second parameter in a second display area of the display screen. The first and second display areas are displayed next to each other such that time axes of the first and second display areas are synchronized with each other.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: July 4, 2023
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Masami Tanishima, Takashi Mato, Shunichi Miyata
  • Patent number: 11684272
    Abstract: Systems and methods for monitoring patient vasoactivity are discussed. An exemplary patient monitor system includes a sensor circuit configured to generate a heart sound (HS) metric using a HS signal sensed from a patient, and a vasoactivity monitor configured to monitor vasoactivity, such as degree of vasoconstriction or vasodilation, using the HS metric. The system can provide the monitored vasoactivity to a user to alert patient hemodynamic responses to vasoactive drugs, or initiate or adjust a vasoactive therapy according to the vasoactivity. The system may use the monitored vasoactivity to detect a medical condition such as worsening heart failure, pulmonary edema, or syncope.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: June 27, 2023
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Pramodsingh Hirasingh Thakur, Viktoria A. Averina, Qi An
  • Patent number: 11679264
    Abstract: The present disclosure provides systems and methods for generating burst waveforms. An implantable neurostimulation system includes an implantable stimulation lead including a plurality of contacts, and an implantable pulse generator communicatively coupled to the stimulation lead. The pulse generator is configured to generate a waveform including a burst that includes a leading anodic pulse followed by alternating cathodic pulses and anodic pulses, each cathodic pulse in the burst having a greater amplitude than the previous cathodic pulse.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: June 20, 2023
    Assignee: ADVANCED NEUROMODULATION SYSTEMS, INC.
    Inventors: Simeng Zhang, Hyun-Joo Park, Filippo Agnesi, Yagna Pathak, Erika Ross
  • Patent number: 11672988
    Abstract: An extra-cardiovascular medical device is configured to select a capacitor configuration from a capacitor array and deliver a low voltage, pacing pulse by discharging the selected capacitor configuration across an extra-cardiovascular pacing electrode vector. In some examples, the medical device is configured to determine the capacitor configuration based on a measured impedance of the extra-cardiovascular pacing electrode vector.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: June 13, 2023
    Assignee: Medtronic, Inc.
    Inventors: Amy E. Thompson-Nauman, Melissa G.T. Christie, Mark T. Marshall, Thomas H. Spear
  • Patent number: 11676340
    Abstract: A system for computational localization of fibrillation sources is provided. In some implementations, the system performs operations comprising generating a representation of electrical activation of a patient's heart and comparing, based on correlation, the generated representation against one or more stored representations of hearts to identify at least one matched representation of a heart. The operations can further comprise generating, based on the at least one matched representation, a computational model for the patient's heart, wherein the computational model includes an illustration of one or more fibrillation sources in the patient's heart. Additionally, the operations can comprise displaying, via a user interface, at least a portion of the computational model. Related systems, methods, and articles of manufacture are also described.
    Type: Grant
    Filed: June 6, 2022
    Date of Patent: June 13, 2023
    Assignee: The Regents of the University of California
    Inventors: David E. Krummen, Andrew D. McCulloch, Christopher T. Villongco, Gordon Ho
  • Patent number: 11672985
    Abstract: Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a first monitor and a controller. The pulse generator is adapted to generate a neural stimulation signal for a neural stimulation therapy. The neural stimulation signal has at least one adjustable parameter. The first monitor is adapted to detect an undesired effect. In some embodiments, the undesired effect is myocardial infarction. The controller is adapted to respond to the first monitor and automatically adjust the at least one adjustable parameter of the neural stimulation signal to avoid the undesired effect of the neural stimulation therapy. Other aspects are provided herein.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: June 13, 2023
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: Imad Libbus
  • Patent number: 11660457
    Abstract: A leadless cardiac pacemaker device is configured to provide HIS bundle pacing and contains a housing having a tip, a first electrode arranged on the housing in the vicinity of the tip, the first electrode being configured to engage with intra-cardiac tissue, and a second electrode arranged on the housing at a distance from the tip of the housing. A processor is enclosed in the housing and operatively connected to the first electrode and the second electrode. The processor is configured to process a reception signal received by at least one of the first electrode and the second electrode and to generate a pacing signal to be emitted using at least one of the first electrode and the second electrode.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: May 30, 2023
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Nicholas R. Anderson, Jeffrey A. Von Arx, Hannes Kraetschmer
  • Patent number: 11656306
    Abstract: A magnetic resonance apparatus includes a scanner, a patient accommodating region, a patient support apparatus which can be moved within the patient accommodating region and a patient communication device. The patient communication device includes at least one communication element which has a radio-frequency transmitter.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: May 23, 2023
    Assignee: Siemens Healthcare GmbH
    Inventor: Jan Bollenbeck
  • Patent number: 11654287
    Abstract: The present technology is generally directed to implantable medical device systems configured to provide cardiac resynchronization therapy. In some embodiments, the implantable medical device system comprises a housing, electrodes carried by the housing, a transducer configured to produce input voltage signals in response to ultrasound energy, and a circuit configured to provide, via an electrical pathway, output voltage signals based on the input voltage signals. The circuit comprises a movable switch, and a slew rate detector configured to detect whether a voltage rate of an individual pulse of the input voltage signals exceeds a predetermined threshold voltage rate. The circuit is configured to move the switch to an open position in response to the detected voltage rate exceeding the predetermined threshold voltage rate.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: May 23, 2023
    Assignee: EBR Systems, Inc.
    Inventor: Parker N. Willis
  • Patent number: 11647951
    Abstract: An input device includes two conductors that are sewn onto a fiber sheet and an output unit configured to determine an impedance variation in a predetermined area on the basis of a voltage value between the two conductors to which a high-frequency current is applied.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: May 16, 2023
    Assignee: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
    Inventor: Satoru Nebuya
  • Patent number: 11647942
    Abstract: A device and method for monitoring a human heart rate to determine whether a bradyarrhythmia event has occurred and if so determined, an electrocardiogram (ECG) rhythm strip is begun to be generated on a continuous basis in real-time and wirelessly communicated to a third party such as the patient's treating physician. The method comprises a pair of sensors for detecting heart rate, each sensor in contact with a respective ear of the patient. If a bradyarrhythmia event is determined; applying an anticholinergic medication to the conjunctiva of at least one eye and releasing ammonia vapor for inhalation by the patient.
    Type: Grant
    Filed: September 26, 2022
    Date of Patent: May 16, 2023
    Assignee: Stat Capsule Inc.
    Inventor: Yuri Busiashvili
  • Patent number: 11642540
    Abstract: An implantable lead includes a lead body, electrical conductors, and a lead anchor. The lead body includes an electrode segment configured to be positioned along a pericardial membrane of a heart and including a plurality of electrodes configured to at least one of sense electrical signals from the heart or deliver therapy to the heart. The electrical conductors extend through the lead body between distal and proximal ends of the lead body, and are configured to electrically couple the electrodes to a pulse generator. The lead anchor is configured to be secured to a chest wall. The electrical conductors extend through the lead anchor, and the electrode segment extends from the lead anchor to the pericardial membrane. The electrode segment includes a transition portion that is configured to extend a depth into a mediastinum and a contoured portion to extend alongside and curve about the pericardial membrane.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: May 9, 2023
    Assignee: Pacesetter, Inc.
    Inventors: Gene A. Bornzin, Zoltan Somogyi, Kyungmoo Ryu
  • Patent number: 11645899
    Abstract: A variety of methods, medical devices, responder network servers, emergency services interfaces and call center related processes are described that can help improve responder networks designed to get a medical device such as an automated external defibrillator and/or volunteer responders to the scene of a potential medical incident.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: May 9, 2023
    Assignee: Avive Solutions, Inc.
    Inventors: Sameer Jafri, Micah R. Bongberg, Rory M. Beyer, Gordon Moseley P. Andrews
  • Patent number: 11640755
    Abstract: System and methods for delivering defibrillator incident information to a PSAP in real-time during emergency use of an AED are described. Such information is utilized by a telecommunicator at a PSAP to provide better guidance to volunteer caregivers during potential cardiac arrest incidents. In another aspect the AED's current instruction state and optionally the time in that state is provided to the PSAP.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: May 2, 2023
    Assignee: Avive Solutions, Inc.
    Inventors: Rory M. Beyer, Micah R. Bongberg, Sameer Jafri, Gordon Moseley P. Andrews
  • Patent number: 11633606
    Abstract: The invention provides methods related to improving heart function.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: April 25, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: David Kass, Gordon Tomaselli, Jonathan Kirk
  • Patent number: 11633600
    Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: April 25, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Bruce KenKnight, Scott Stubbs, Scott Mazar
  • Patent number: 11621648
    Abstract: The present disclosure concerns a circuit (302) for controlling two switches (210-1, 210-2) electrically in series, including sensors (310-1, 310-2) of voltages across the switches and a circuit (310) of comparison of signals output by said sensors, one at least of said sensors being an active circuit.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: April 4, 2023
    Assignee: Commissariat à l'Energie Atomique et aux Energies Alternatives
    Inventors: Léo Sterna, Pierre Perichon
  • Patent number: 11612749
    Abstract: A method for assessing a patient's suitability for receiving a vagus nerve stimulation therapy includes receiving a criterion regarding the patient's suitability for receiving a vagus nerve stimulation therapy; controlling a stimulation device to provide stimulation to a vagus nerve of the patient; receiving, from a sensor, response data indicative of a physiological response of the patient to the stimulation of the vagus nerve; and determining the patient's suitability for receiving the vagus nerve stimulation therapy based on the criterion and the physiological response of the patient to the stimulation.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: March 28, 2023
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Bruce H. Kenknight, Christine Henry
  • Patent number: 11610312
    Abstract: An image processing apparatus for evaluating cardiac images and a ventricular status identification method are provided. In the method, a region of interest (ROI) is determined from multiple target images, a variation in grayscale values of multiple pixels in the ROIs of each target image is determined, and one or more representative images are obtained according to the variation in the grayscale values. The target image is related to the pixels within an endocardial contour of a left ventricle. A boundary of the ROI is approximately located at two sides of a bottom of the endocardial contour. The ROI corresponds to a mitral valve. The variation in the grayscale values is related to a motion of the mitral valve. The representative image is for evaluating a status of the left ventricle.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: March 21, 2023
    Assignee: Acer Incorporated
    Inventors: Hung-Sheng Hsu, Chien-Hung Li, Yi-Jin Huang
  • Patent number: 11602299
    Abstract: A method and a system for processing an electroencephalogram (EEG) signal are provided. The method for processing the EEG signal includes: performing a spike detection on the EEG signal to obtain a spike distribution waveform, performing an instantaneous frequency oscillation energy analysis on the EEG signal to obtain multiple energy distribution waveforms; performing a complexity analysis on the EEG signal to obtain a complexity change waveform, obtaining a determination result of a specified neural waveform based on the spike distribution waveform, the energy distribution waveforms, and the complexity change waveform, and outputting the determination result.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: March 14, 2023
    Assignee: A-Neuron Electronic Corporation
    Inventors: Chia-Chi Chang, Pei-Chen Lin, Yue-Loong Hsin
  • Patent number: 11602639
    Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, the plurality of electrodes forming a first sensing vector and a second sensing vector, identifying the cardiac event as one of a shockable event and a non-shockable event in response to first processing of a first interval sensed along the first sensing vector during a predetermined sensing window and a second interval simultaneously sensed along the second sensing vector, performing second processing of the first interval and the second interval, different from the first processing, in response to the cardiac event being identified as a shockable event, and determining whether to delay identifying the cardiac event being shockable in response to the second processing of the first interval and the second interval.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: March 14, 2023
    Assignee: Medtronic, Inc. (CVG)
    Inventors: Xusheng Zhang, Robert W. Stadler
  • Patent number: 11590353
    Abstract: Implantable medical devices (IMD), such as but not limited to leadless cardiac pacemakers (LCP), subcutaneous implantable cardioverter defibrillators (SICD), transvenous implantable cardioverter defibrillators, neuro-stimulators (NS), implantable monitors (IM), may be configured to communicate with each other. In some cases, a first IMD may transmit instructions to a second IMD. In order to improve the chances of a successfully received transmission, the first IMD may transmit the instructions several times during a particular time frame, such as during a single heartbeat. If the second IMD receives the message more than once, the second IMD recognizes that the messages were redundant and acts accordingly.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: February 28, 2023
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Brendan Early Koop, Paul Huelskamp, Lance Eric Juffer, Kyle Leonard Nelson, Keith R. Maile, Jacob M. Ludwig
  • Patent number: 11583676
    Abstract: The present disclosure relates generally to systems, methods, and devices for interpreting neural signals to determine a desired movement of a target, transmitting electrical signals to the target, and dynamically monitoring subsequent neural signals or movement of the target to change the signal being delivered if necessary, so that the desired movement is achieved. In particular, the neural signals are decoded using a feature extractor, decoder(s) and a body state observer to determine the electrical signals that should be sent.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: February 21, 2023
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Chad E. Bouton, Nicholas Annetta, David A. Friedenberg, Gaurav Sharma
  • Patent number: 11576605
    Abstract: A medical device is utilized to monitor physiological parameters of a patient and capture segments of the monitored physiological parameters. The medical device includes circuitry configured to monitor one or more physiological parameters associated with the patient and an analysis module that includes a buffer and a processor. The buffer stores monitored physiological parameters and the processor analyzes the monitored physiological parameters and triggers capture of segments from the buffer in response to a triggering criteria being satisfied. The analysis module selects a pre-trigger duration based at least in part on the triggering criteria.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: February 14, 2023
    Assignee: Medtronic Monitoring, Inc.
    Inventors: Rodolphe Katra, Scott Williams, Niranjan Chakravarthy