Heart Rate Regulating (e.g., Pacing) Patents (Class 607/9)
  • Patent number: 11027134
    Abstract: This disclosure relates to an active implantable medical device of the cardiac resynchronizer type. The device includes a pulse generator to produce pacing pulses, at least one detection electrode for detecting atrial and ventricular events, at least one stimulation electrode, a memory storing executable instructions, and a processor configured to execute the instructions. The processor is configured to execute the instructions to apply an atrioventricular delay (AVD) between a sensed or stimulated atrial event and the delivery of a ventricular pacing pulse, quantify a degree of fusion between the delivery of a pacing pulse to a cavity and a spontaneous contraction of another cavity, calculate a fusion rate, and modify the value of the AVD applied to the delivery of said ventricular pacing pulse, as a function of a comparison.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 8, 2021
    Assignee: Sorin CRM SAS
    Inventors: Paola Milpied, Delphine Feuerstein
  • Patent number: 11027136
    Abstract: Systems and methods for His bundle pacing using a stimulation device include applying an impulse to a His bundle of a patient heart using the stimulation device. The stimulation device then measures a response of the patient heart to application of the impulse that includes a response of a ventricle of the patient heart. The stimulation device calculates a ventricular delay as a time from application of the impulse to onset of the response of the ventricle and delivers, using a lead of the stimulation device, a backup impulse to the ventricle when at least the ventricular delay exceeds a delay value stored in a memory of the stimulation device. The stored delay may, for example, correspond to a previously determined value indicative of selective or other His bundle capture.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: June 8, 2021
    Assignee: PACESETTER, INC.
    Inventors: Jan O. Mangual-Soto, Wenwen Li, Nima Badie, Luke C. McSpadden
  • Patent number: 11027135
    Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: June 8, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Subham Ghosh, Jeffrey M. Gillberg, Robert W. Stadler
  • Patent number: 11013912
    Abstract: Medical device systems, methods, and algorithms are disclosed for providing complex stimulation waveforms. The waveforms may selectively modulate or activate specific neural targets or selected ratios of specific neural targets. Some of the waveforms include pre-pulse phases defined by parameters, the value of which changes during the pre-pulse phase. Also disclosed herein are graphical user interfaces (GUIs) that allow the selection of waveforms configured to selectively modulate or activate specific neural targets or selected ratios of the neural targets. Adjustable parameters of the waveforms are adjusted automatically based on selection of user-defined parameters.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: May 25, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, G. Karl Steinke, Richard Mustakos
  • Patent number: 11013925
    Abstract: A medical device and medical device system for controlling delivery of therapeutic stimulation pulses that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to receive the trigger signal and deliver therapy to the patient in response to the emitted trigger signal, and a processor positioned within the sensing device, the processor configured to determine whether the sensed cardiac signal exceeds a possible P-wave threshold, compare a portion of the sensed cardiac signal to a P-wave template having a sensing window having a length less than a width of the P-wave, confirm an occurrence of a P-wave signal in response to the comparing, emit the trigger signal in response to the occurrence of a P-wave signal being confirmed, and inhibit delivery of the emitting signal in response to the occurrence of a P-wave signal not being confirmed.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: May 25, 2021
    Assignee: Medtronic, Inc.
    Inventors: Subham Ghosh, Juan Du, Saul E. Greenhut, Michael T. Hemming
  • Patent number: 11000688
    Abstract: A Medical Device Application (MDA) is disclosed for an external device (e.g., a cell phone) that can communicate with an Implantable Medical Device (IMD). The MDA receives data logged in the IMD, processes that data in manners reviewable by an IMD patient, and that can control the IMD based on such processed data. The MDA can use the logged data to adjust IMD therapy based on patient activity or posture, and allows a patient to learn optimal therapy settings for particular activities. The MDA can also use the logged data to allow a patient to review details about IMD battery performance, whether such battery is primary or rechargeable, and to control stimulation parameters based on that performance. The MDA also allows a patient to enter medicine dose information, to review the relationship between medicinal therapy and IMD therapy, and to adjust IMD therapy based on the dosing information.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: May 11, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Samuel Tahmasian
  • Patent number: 10994141
    Abstract: An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation pattern for conveying the cognitive variable. The processing unit employs an adaptive algorithm to assemble the stimulation pattern by combination of subset stimulation patterns, the combination of subset stimulation patterns learned by the adaptive algorithm through error analysis.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: May 4, 2021
    Assignee: The Trustees of Princeton University
    Inventor: Tim Buschman
  • Patent number: 10981010
    Abstract: Implantable medical systems enter an exposure mode of operation, either manually via a down linked programming instruction or by automatic detection by the implantable system of exposure to a magnetic disturbance. A controller then determines the appropriate exposure mode by considering various pieces of information including the device type including whether the device has defibrillation capability, pre-exposure mode of therapy including which chambers have been paced, and pre-exposure cardiac activity that is either intrinsic or paced rates. Additional considerations may include determining whether a sensed rate during the exposure mode is physiologic or artificially produced by the magnetic disturbance. When the sensed rate is physiologic, then the controller uses the sensed rate to trigger pacing and otherwise uses asynchronous pacing at a fixed rate.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: April 20, 2021
    Assignee: Medtronic, Inc.
    Inventors: Hyun J. Yoon, Wade M. Demmer, Matthew J. Hoffman, Robert A. Betzold, Jonathan D. Edmonson, Michael L. Ellingson, Ben W. Herberg, Juliana E. Pronovici, James D. Reinke, Todd J. Sheldon, Paul R. Solheim
  • Patent number: 10981009
    Abstract: A medical device comprises therapy delivery circuitry and processing circuitry. The therapy delivery circuitry is configured to deliver anti-tachycardia pacing (ATP) therapy to a heart of a patient. The ATP therapy includes one or more pulse trains and each of the one or more pulse trains includes a plurality of pacing pulses. The processing circuitry is configured to, for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse. The processing circuitry is further configured to modify the ATP therapy based on the at least one latency metric.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: April 20, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Troy E. Jackson, Vincent P. Ganion
  • Patent number: 10973430
    Abstract: A system is disclosed including: one or more electroencephalography (EEG) sensor nodes in a fully reconfigurable sensor network configured to detect electrical signals indicating activity of a brain of a subject and to transmit signal information relating to the detected electrical signals, each EEG sensor node embodying an analog front end (AFE) circuit, and a centralized command control node (CCN) in the sensor network in communication with the one or more EEG sensor nodes and configured to receive the transmitted signal information from the one or more EEG sensor nodes and to perform a processing technique on the received information resulting in processed signal data, wherein the one or more EEG sensor nodes are configured to detect the electrical signals without a driven right leg (DRL) circuit in the sensor network.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: April 13, 2021
    Inventors: Bashir I. Morshed, Ruhi Mahajan
  • Patent number: 10967189
    Abstract: Baseline BiV pacing is delivered and a corresponding baseline BiV efficacy score is determined. Intrinsic AV conduction is allowed and an intrinsic AV conduction interval is determined. BiV fusion pacing is delivered and a corresponding efficacy score is determined, for each of a plurality of different paced AV delays, each determined based on the intrinsic AV conduction interval and a different negative hysteresis delta. The baseline BiV pacing is selected for delivery during a period of time if the baseline BiV efficacy score is better than all of the efficacy scores. BiV fusion pacing is selected for delivery during the period of time, using one of the plurality of different paced AV delays for which a corresponding efficacy score was determined, if the efficacy score corresponding to at least one of the plurality of different paced AV delays is better than the baseline BiV efficacy score.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: April 6, 2021
    Assignee: Pacesetter, Inc.
    Inventors: Brian Wisnoskey, Yelena Nabutovsky, Jennifer Rhude, Gary Cranke
  • Patent number: 10967147
    Abstract: Embodiments of the present disclosure include a system for determining an error associated with an electrode disposed on a medical device. The system comprises a processor and a memory storing instructions on a non-transitory computer-readable medium. The instructions are executable by the processor to receive an electrode signal from the electrode disposed on the medical device. The instructions are further executable by the processor to receive a plurality of other electrode signals from a plurality of other electrodes disposed on the medical device. The instructions are further executable by the processor to determine that the electrode signal received from the electrode disposed on the medical device is an outlier in relation to the plurality of other electrode signals from the plurality of other electrodes disposed on the medical device, based on a comparison between the electrode signal and the plurality of other electrode signals.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 6, 2021
    Assignee: St. Jude Medical International Holding S.à r.l.
    Inventors: Eitan Oren, Oded Sudarsky, Adar Shlain, Stavit Cohen, Alexander Zaslavky, Silvina Rybnikov, Maxim Yoresh
  • Patent number: 10937548
    Abstract: A method of improving data sets, for example, of patients, each being characterized by relatively low-cost medical data, identifies those patients where the acquisition of higher cost medical data would best inform an estimate of the higher cost medical data for the remaining patients. In this way scarce medical resources can be more efficiently applied in characterizing a potential patient pool, for example, for a clinical trial when resources are not available for extensive medical characterization of each trial participant.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: March 2, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Won Hwa Kim, Seong Jae Hwang, Nagesh Adluru, Sterling Johnson, Vikas Singh
  • Patent number: 10828493
    Abstract: Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a first monitor and a controller. The pulse generator is adapted to generate a neural stimulation signal for a neural stimulation therapy. The neural stimulation signal has at least one adjustable parameter. The first monitor is adapted to detect an undesired effect. In some embodiments, the undesired effect is myocardial infarction. The controller is adapted to respond to the first monitor and automatically adjust the at least one adjustable parameter of the neural stimulation signal to avoid the undesired effect of the neural stimulation therapy. Other aspects are provided herein.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 10, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: Imad Libbus
  • Patent number: 10796246
    Abstract: A Brain-Mobile Interface (BMoI) system is provided. A control circuit is configured to execute a predictive model to generate a defined number of predicted signal features in future time based on a number of signal features extracted from a first type sensory data (e.g., electroencephalogram (EEG) data). A predicted future mental state(s) can thus be generated based on the number of predicted signal features and used to trigger a corresponding action(s) in a BMoI application(s). In a non-limiting example, a second type sensory data (e.g., electrocardiogram (ECG) data) can be used to improve accuracy of the predictive model. By using the predicted signal features to generate the predicted future mental state(s) to control the BMoI application(s), it is possible to duty-cycle the BMoI system to help reduce power consumption and processing latency, thus allowing the BMoI application(s) to operate in real-time with improved accuracy and power consumption.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: October 6, 2020
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Sandeep Gupta, Ayan Banerjee, Mohammad Javad Sohankar Esfahani, Seyed Koosha Sadeghi Oskooyee
  • Patent number: 10780279
    Abstract: Methods and systems of evaluating cardiac pacing in candidate patients for cardiac resynchronization therapy and cardiac resynchronization therapy patients are disclosed. The methods and systems disclosed allow treatments to be personalized to patients by measuring the extent of tissue capture from cardiac pacing under various therapy parameter conditions. Systems and methods of optimizing right ventricle only cardiac pacing are also disclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: September 22, 2020
    Assignee: Medtronic, Inc.
    Inventor: Subham Ghosh
  • Patent number: 10765860
    Abstract: A subcutaneous implantable medical device and method (SIMD) provided. A pulse generator (PG) is configured to be positioned subcutaneously within a lateral region of a chest of a patient. The PG has a housing that includes a PG electrode. The PG has an electronics module. An elongated lead is electrically coupled to the pulse generator. The elongated lead includes a first electrode that is configured to be positioned along a first parasternal region proximate a sternum of the patient and a second electrode that is configured to be positioned at an anterior region of the patient. The first and second electrodes are coupled to be electrically common with one another. The electronics module is configured to provide electrical shocks for antiarrhythmic therapy along at least one shocking vector between the PG electrode and the first and second electrodes.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: September 8, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Xiaoyi Min, Kyungmoo Ryu, Keith Victorine, Stuart Rosenberg, Gene A. Bornzin
  • Patent number: 10758730
    Abstract: Methods, devices and program products are provided for controlling a left univentricular (LUV) pacing therapy using an implantable medical device. Electrodes are configured to be located proximate to an atrial (A) site, left ventricular (LV) site and right ventricular (RV) site of the heart. A conduction different ? is determined based on i) an atrial-ventricular conduction delay (ARRV) between the A site and the RV site, and ii) an atrial-ventricular conduction delay (ARLV) between the A site and the LV site. A correction term ? is based on intrinsic inter-ventricular conduction delay (IVCD) between the LV and RV. An LV atrial-ventricular pacing (AVLV) delay is set based on the conduction difference ?, a pacing latency PL and the correction term ? and manages the LUV pacing therapy based on the AVLV delay, wherein the LUV pacing therapy lacks pacing in the RV.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: September 1, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Xiaoyi Min, Kyungmoo Ryu, Stuart Rosenberg, David Muller
  • Patent number: 10758138
    Abstract: Implantable medical device systems and methods configured to use a detection profile selected from among a plurality of detection profiles to define a detection threshold for identifying cardiac events, in which a close call definition is used to determine which of the plurality of detection profiles is to be chosen. Upon identifying a close call, in which an overdetection nearly occurred but did not actually take place, a relatively less sensitive detection profile is chosen.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: September 1, 2020
    Assignee: CAMERON HEALTH, INC.
    Inventor: Venugopal Allavatam
  • Patent number: 10758737
    Abstract: A medical system for sensing and regulating cardiac activity of a patient may include a cardioverter that is configured to generate and deliver shocks to cardiac tissue and a leadless cardiac pacemaker (LCP) that is configured to sense cardiac activity and to communicate with the cardioverter. The cardioverter may be configured to detect a possible arrhythmia and, upon detecting the possible arrhythmia, may send a verification request to the LCP to help conform that the possible arrhythmia is occurring. The LCP, upon receiving the verification request from the cardioverter, may be configured to activate one or more of a plurality of sensors to attempt to help confirm that the possible arrhythmia is occurring.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: September 1, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Qi An, Pramodsingh Hirasingh Thakur, Jeffrey E. Stahmann, Yinghong Yu, Michael J. Kane
  • Patent number: 10744332
    Abstract: A leadless cardiac pacemaker is provided which can include any number of features. In one embodiment, the pacemaker can include a tip electrode, pacing electronics disposed on a p-type substrate in an electronics housing, the pacing electronics being electrically connected to the tip electrode, an energy source disposed in a cell housing, the energy source comprising a negative terminal electrically connected to the cell housing and a positive terminal electrically connected to the pacing electronics, wherein the pacing electronics are configured to drive the tip electrode negative with respect to the cell housing during a stimulation pulse. The pacemaker advantageously allows p-type pacing electronics to drive a tip electrode negative with respect to the can electrode when the can electrode is directly connected to a negative terminal of the cell. Methods of use are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: August 18, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Kenneth J. Carroll, Alan Ostroff, Peter M. Jacobson
  • Patent number: 10737102
    Abstract: An implantable medical device (IMD) may include a fixation module, and a device module that is configured to be releasably connected to the fixation module. The device module may have a proximal end and a distal end, and may include a power source and a controller that is operably coupled to the power source. The controller may be configured to sense cardiac electrical activity via two or more electrodes and/or deliver pacing pulses via two or more electrodes. The device module may include a first part of a releasable connector while the fixation module may include a second part of the releasable connector, wherein the first part of the releasable connector and the second part of the releasable connector cooperate to releasably connect the device module with the fixation module.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 11, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Erin Kristen Webb, Bryan J. Swackhamer, Dana Sachs
  • Patent number: 10735887
    Abstract: A spatial audio processing system operable to enable audio signals to be spatially extracted from, or transmitted to, discrete locations within an acoustic space. Embodiments of the present disclosure enable an array of transducers being installed in an acoustic space to combine their signals via inverting physical and environmental models that are measured, learned, tracked, calculated, or estimated. The models may be combined with a whitening filter to establish a cooperative or non-cooperative information-bearing channel between the array and one or more discrete, targeted physical locations in the acoustic space by applying the inverted models with whitening filter to the received or transmitted acoustical signals. The spatial audio processing system may utilize a model of the combination of direct and indirect reflections in the acoustic space to receive or transmit acoustic information, regardless of ambient noise levels, reverberation, and positioning of physical interferers.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: August 4, 2020
    Assignee: Wave Sciences, LLC
    Inventors: James Keith McElveen, Gregory S. Nordlund, Jr., Leonid Krasny
  • Patent number: 10668292
    Abstract: Embodiments describe herein generally pertain to implantable medical device (IMDs), and methods for use therewith, that can be used to automatically switch an IMD from its normal operational mode to an MRI safe mode, and vice versa, within increased specificity. In certain embodiments, a controller of the IMD uses a magnetic field sensor to determine whether a first magnetic field condition is detected, and uses an accelerometer to determine whether a positional condition is detected. In response to the first magnetic field condition being detected, and the positional condition being detected, the controller can use the magnetic field sensor to determine whether a second magnetic field condition is detected, which differs from the first magnetic field condition. The controller can then cause the IMD to enter the MRI safe mode based at least in part on the first and second magnetic field conditions and the positional condition being detected.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 2, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Xing Pei, Brad Lindevig, Stuart Rosenberg, Nima Badie
  • Patent number: 10653887
    Abstract: An implantable medical device implements a special mode of operation, such as a mode of electrical stimulation therapy, during conditions where there may be an increased likelihood that a device reset will occur. The implantable medical device recovers from the device reset by copying values that specify the special mode and that are stored in a non-volatile memory to an operating memory. The special mode is implemented after the device reset has occurred by using the values copied to the operating memory. One version of the special mode is an MRI mode that allows the implantable medical device to safely operate during an MRI scan. The fields of the MRI scan may trigger a device reset, but the MRI mode values are copied from the non-volatile memory to the operating memory, and the MRI mode is implemented after the reset by using the values copied to the operating memory.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: May 19, 2020
    Assignee: Medtronic, Inc.
    Inventors: Troy A. Jenison, Michael D. Levy, Benjamin P. Rhodes, Christopher C. Stancer
  • Patent number: 10646720
    Abstract: Implantation of a cardiac stimulus system using parasternal access to the ITV is provided. Superior access may be achieved using parasternal locations in the upper ribcage to access the ITV. Inferior access may be achieved using parasternal locations in the lower ribcage to access the ITV. Parasternal access may include creating an opening in an intercostal space between two ribs and advancing a needle using ultrasound guidance.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: May 12, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventor: G. Shantanu Reddy
  • Patent number: 10649053
    Abstract: Disclosed herein are methods and systems for clinical practice of medical imaging on patients with metal-containing devices, such as implanted cardiac devices. In particular, Disclosed herein are methods and systems for improved late gadolinium enhancement (LGE) MRI for assessing myocardial viability for patients with implanted cardiac devices, i.e., cardiac pacemakers and implantable cardiac defibrillators.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 12, 2020
    Assignee: The Regents of the University of California
    Inventor: Peng Hu
  • Patent number: 10617881
    Abstract: According to at least one aspect, an external medical device is provided. The external medical device includes at least one electrode to detect cardiac activity of a patient, a treatment component to provide a therapy to the patient based at least in part on the detected cardiac activity, a user interface including at least one caregiver interface and at least one patient interface, and a processor in communication with the user interface. The processor may be configured to provide a first set of information to the caregiver interface and a second set of information to the patient interface. The first set of information may include information for operating the external medical device in conjunction with the patient and the second set of information may include information for allowing the patient to cause the external medical device to suspend providing the therapy to the patient.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: April 14, 2020
    Assignee: ZOLL MEDICAL CORPORATION
    Inventors: Trisha A. Pavel, John G. Clark, Edward J. Donnelly, Thomas E. Kaib
  • Patent number: 10603496
    Abstract: An apparatus comprises a stimulus circuit, a cardiac signal sensing circuit, and a control circuit. The cardiac signal sensing circuit senses a cardiac activity signal using a sensing channel. The stimulus circuit provides electrical pulse energy to a first pacing channel that includes a first left ventricular (LV) electrode and a second pacing channel that includes a second LV electrode. The control circuit initiates delivery of electrical pulse energy using the first and second pacing channels according to a first multi-site LV pacing mode; determines a cardiac event associated with a change in cardiac conduction path using a sensed cardiac activity signal; and changes to a second LV pacing mode in response to determining the cardiac event. The second LV pacing mode is different from the first multi-site LV pacing mode in one or more of a pacing site location and inter-electrode stimulus timing.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: March 31, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David J. Ternes, Keith L. Herrmann, Britta Catherine Veldman
  • Patent number: 10589100
    Abstract: Methods and devices are is provided for controlling a pacing therapy utilizing left ventricular multi-point pacing (MPP). The method and device provide electrodes configured to be located proximate to an atrial (A) site, a right ventricular (RV) site and multiple left ventricular (LV) sites of the heart. The method and device utilizes one or more processors. The processors determine atrial-ventricular conduction delays (AVCD) between the A site and multiple corresponding LV sites and determines pacing latencies at the LV sites. The processors adjusts the AVCDs, based on the pacing latency at the corresponding LV sites, to form atrial-ventricular latency adjusted (ARPL) conduction delays for the corresponding LV sites, calculates interventricular pacing (VV) delays for combinations of the LV sites based on the corresponding ARPL conduction delays and manages pacing therapy, that utilizes left ventricular MPP, based on the VV delays for the corresponding LV sites.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 17, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Xiaoyi Min, Kyungmoo Ryu, Stuart Rosenberg, David Muller
  • Patent number: 10583292
    Abstract: An implantable electronic neuromodulation system includes an implantable pulse generator comprising a controller and a memory. The memory is configured to store an emulated neurosensory signal representative of nerve traffic acquired from a patient equipped with an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system. A lead is coupled to the implantable pulse generator. At least one electrode is coupled to the lead. The at least one electrode is positionable in contact with or adjacent to at least one nerve that carries sensory information from baroreceptors. The controller is configured to stimulate the at least one nerve using the emulated neurosensory signal.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: March 10, 2020
    Assignee: CHF Solutions, Inc.
    Inventor: David Lerner
  • Patent number: 10583286
    Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a housing and a plurality of electrodes arranged with the housing. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate L-dopa release.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: March 10, 2020
    Assignee: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
    Inventors: Lynne E. Swanson, William C. Stoffregen, Bryan A. Clark, Michael X. Govea, Dennis B. Werner, Natalie A. Brill, Pramodsingh H. Thakur
  • Patent number: 10556111
    Abstract: An implantable assembly is described for acquisition of neuronal electrical signals at a selected location which propagate along at least one nerve fiber contained in a nerve fiber bundle, as well as for selective electrical stimulation of the at least one nerve fiber, having: an implantable electrode assembly (E) which is disposed on a biocompatible support substrate which can be positioned around the nerve fiber bundle in a cuff, which has a cylindrical support substrate surface (i) which in the implanted condition is orientated facing the nerve fiber bundle, on which a first electrode assembly for locationally selective acquisition of the neuronal electrical signals and selective electrical stimulation of the at least one nerve fiber, and on which a second electrode assembly is disposed to record an ECG signal, and an analysis and control unit (A/S) which can be electrically conductively connected or is connected to the implantable electrode assembly (E), in which the locationally selective acquired neuron
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: February 11, 2020
    Assignee: Neuroloop GmbH
    Inventors: Dennis Plachta, Mortimer Giehrtmuehlen, Thomas Stieglitz, Josef Zentner
  • Patent number: 10549102
    Abstract: Sensors are applied to the heart and sensor data is supplied to a rules engine. The rules engine applies rules that reflect a CRM pharmaceutical regime of the patient to the sensor data to determine whether an electrical waveform should be applied to the heart. When electrical stimulation is warranted, the drug “awareness” rules are used by the rules engine to instruct a multi-phase cardiac stimulus generator to generate an electrical waveform that improves the performance of the drugs administered to the patient, allow the patient to be administered a lower dose of a particular drug, and/or reduce or eliminate side effects from the drugs.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: February 4, 2020
    Assignee: MR3 MEDICAL, LLC
    Inventors: Morton M. Mower, Ralph Hall
  • Patent number: 10547171
    Abstract: A power transistor supplying power to a load is coupled to a current limiter circuit including a differential amplifier that operates to detect a difference between a sense voltage, indicative of a load current, and a voltage reference. A control terminal of the power transistor is driven by a first output of the differential amplifier as a function of the detected difference. A voltage clamp circuit coupled to an input terminal generates a floating ground. A short-circuit protection circuit coupled to the floating ground and interposed between a second output of the differential amplifier and the control terminal of the power transistor provides a short-circuit protection for the first output of the differential amplifier. A reaction time circuit is coupled between the first and second outputs of the differential amplifier and a source terminal of the power transistor to limit a short-circuit current at the source terminal.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: January 28, 2020
    Assignee: STMicroelectronics S.r.l.
    Inventors: Ignazio Bruno Mirabella, Francesco Pulvirenti, Salvatore Pappalardo
  • Patent number: 10517540
    Abstract: Described herein are systems and methods for reducing the size of data payloads delivered to downstream processing from a raw series of biological sensor recordings. In one variation, the system comprises a low-power hardware architecture that combines serially sampled neural signal data with a transformation matrix (TFM) using a novel systolic random-logic-macro (RLM) array.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: December 31, 2019
    Assignee: HI LLC
    Inventors: Kristopher Anderson, Randal Koene, Antonio H. Lara, John W. Stanton
  • Patent number: 10518089
    Abstract: A method of providing therapy to a patient using a plurality of electrodes is provided. The electrodes are located adjacent a target neural tissue region having a first nerve fiber of a relatively small diameter and a second nerve fiber of a relatively large diameter. The method comprises sourcing electrical current from a local anode into the target neural tissue region. The method further comprises therapeutically sinking a first portion of the electrical current from the target neural tissue region into a local cathode. The method further comprises sinking a second portion of the electrical current into a cathode remote from the target neural tissue region. The ratio of the sourced electrical current over the first sunk electrical current portion has a value that allows the first nerve fiber to be recruited by the electrical current while preventing the second nerve fiber from being recruited by the electrical current.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 31, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Dongchul Lee, Kerry Bradley, David K. L. Peterson
  • Patent number: 10506939
    Abstract: A method, including, receiving a first group of electrocardiograph (ECG) signals derived from a single heartbeat and generated at a respective plurality of electrodes on a catheter in a heart of a subject, formulating a template relating times of annotations of the first group of the ECG signals, and assigning the template an index. The method further includes receiving a second group of ECG signals derived from a subsequent single heartbeat and generated at the electrodes, calculating times of annotations of the second group, formulating a comparison between the template and the times of annotations of the second group, and, when the comparison indicates that the times of annotations of the second group correspond to the template, assigning the index to the second group of ECG signals, and presenting graphically on a display an occurrence of the template relative to a timeline representing heartbeats from the heart.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: December 17, 2019
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Vladimir Rubinstein, Meir Bar-Tal
  • Patent number: 10485439
    Abstract: Fast recovery electrocardiogram (ECG) signal method and apparatus are provided. In one embodiment, an ECG apparatus includes an input for receiving a biometric cardiogram signal, such as a Wilson Central Terminal (WCT) signal, and a combiner, such as an adder, for producing a compensated signal. An analog to digital converter provides a digitized version of the compensated signal to a processor. The processor produces an ECG reflective of the compensated signal and also outputs a digital signal corresponding to high frequency response of the digitized compensated signal to a digital to analog converter. The digital to analog converter provides an analog version of the digital signal corresponding to high frequency response of the digitized compensated signal to compensate for low response of the biometric cardiogram signal to high frequency spikes. A resultant ECG is produced by the processor having pacing signal contribution within the biometric cardiogram signal cancelled.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 26, 2019
    Assignee: BIOSENSE WEBSTER (ISREAL) LTD.
    Inventor: Assaf Govari
  • Patent number: 10478627
    Abstract: An implantable leadless pacemaker (iLP) for a human or animal heart is provided that includes a housing, at least two electrode poles for picking up electrical potentials and/or delivering electrical stimulation, a stimulation control unit in connection with the electrode poles, a sensing unit that is in connection with at least one electrode pole, a signal processing unit in connection with the sensing unit, a signal evaluation unit in connection with the signal processing unit and/or the sensing unit, and an energy source. The sensing unit is configured to sense a first signal associated with an activity of the first heart chamber, and the stimulation control unit is configured to deliver electrical stimulation in the first heart chamber via the at least two electrode poles. The sensing unit is configured to sense a second signal associated with an activity of a second heart chamber.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: November 19, 2019
    Assignee: Biotronik SE & Co. KG
    Inventors: Dirk Muessig, Andrew Kibler, Larry Stotts, Brian M. Taff
  • Patent number: 10448855
    Abstract: In situations in which an implantable medical device (IMD) (e.g., an extravascular ICD) is co-implanted with a leadless pacing device (LPD), it may be important that the IMD knows when the LPD is delivering pacing, such as anti-tachycardia pacing (ATP). Techniques are described herein for detecting, with the IMD and based on the sensed electrical signal, pacing pulses and adjusting operation to account for the detected pulses, e.g., blanking the sensed electrical signal or modifying a tachyarrhythmia detection algorithm. In one example, the IMD includes a pace pulse detector that detects, based on the processing of sensed electrical signals, delivery of a pacing pulse from a second implantable medical device and blank, based on the detection of the pacing pulse, the sensed electrical signal to remove the pacing pulse from the sensed electrical signal.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: October 22, 2019
    Assignee: Medtronic, Inc.
    Inventors: James D. Reinke, Xusheng Zhang, Vinod Sharma, Vladimir P. Nikolski, Michael B. Terry, Scott A. Hareland, Daniel L. Hansen, Donna M. Salmi
  • Patent number: 10449368
    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: October 22, 2019
    Assignee: Medtronic, Inc.
    Inventors: Aleksandre T. Sambelashvili, Thomas J. Mullen, Todd J. Sheldon
  • Patent number: 10441794
    Abstract: Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: October 15, 2019
    Assignee: BackBeat Medical, Inc.
    Inventors: Yuval Mika, Darren Sherman, Robert S. Schwartz, Robert A. Van Tassel, Daniel Burkhoff
  • Patent number: 10441797
    Abstract: A medical device for stimulating the heart using biventricular stimulation. The device includes a sensor for detecting an endocardial acceleration parameter and a processing circuit configured to receive the endocardial acceleration parameter. The device further includes stimulation electronics coupled to the processing circuit. The processing circuit is configured to use the EA parameter to evaluate the biventricular stimulation. The evaluation includes comparing the value of the EA parameter in biventricular mode to the value of the EA parameter in left only mode or right only mode, and using the comparison and an assessment of the variability of the EA parameter as a function of the AVD in the left or right mode to distinguish between cases comprising: (a) normal operation, (b) a loss of RV or LV capture, (c) possible anodal stimulation. The processing circuit is further configured to conduct at least one update to operational parameters of the device based on the determined case.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: October 15, 2019
    Assignee: Sorin CRM SAS
    Inventors: Filippo Ziglio, Fabrizio Renesto
  • Patent number: 10391318
    Abstract: A medical device and medical device system for determining capture during delivery of a ventricular pacing therapy that includes a subcutaneous sensing device comprising a subcutaneous electrode to sense a subcutaneous cardiac signal and to emit a trigger signal in response to the sensed cardiac signal, an intracardiac therapy delivery device capable of being implanted within a left ventricle of a heart to receive the trigger signal and deliver the ventricular pacing therapy to the left ventricle in response to the emitted trigger signal, and a processor positioned within the subcutaneous sensing device, the processor configured to compare a beat of the subcutaneous cardiac signal sensed by the sensing device subsequent to the ventricular pacing therapy being delivered to a baseline template associated with a non-paced beat, and determine whether the delivered ventricular pacing therapy captures the left ventricle in response to the comparing.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 27, 2019
    Assignee: Medtronic, Inc.
    Inventor: Subham Ghosh
  • Patent number: 10391302
    Abstract: A device for electrical stimulation of one or more components of the periodontal complex and surrounding tissue of a tooth, for uses such as reducing orthodontic pain and encouraging tooth movement, has electrodes of a rigid, electrically conductive material in a fixed spatial relationship configured for application to oral mucosa and attached gingiva adjacent to, and along a periodontal ligament of, a root structure of a single tooth. An electrical circuit is configured for electrical connection to the at least two electrodes. The electrical circuit has an output providing a subsensory electrical stimulus comprising a waveform in accordance with predetermined stimulation parameters. After the electrodes are applied to the oral mucosa and attached gingiva adjacent to, and along the periodontal ligament of, a root structure of the tooth, a switch, when activated, activates the electrical circuit to output the electrical stimulus through the at least two electrodes.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: August 27, 2019
    Inventor: Cosmo Haralambidis
  • Patent number: 10314651
    Abstract: Systems and methods for monitoring and performing tissue modulation are disclosed. An example system may include an elongate shaft having a distal end region and a proximal end and having at least one modulation element and one sensing electrode disposed adjacent to the distal end region. The sensing electrode may be used to determine and monitor changes in tissue adjacent to the modulation element.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: June 11, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Leonard B. Richardson, Scott R. Smith, Mark L. Jenson
  • Patent number: 10285647
    Abstract: A method and system are provided for assigning map points to anatomical segments of a heart. The method and system utilize an intravascular mapping tool configured to be inserted into at least one of the endocardial or epicardial space. The mapping tool is maneuvered to select locations proximate to surfaces of the heart, while collecting map points at the select locations to form a ROI data set. The method and system store the ROI data set in a data storage and defines apical, basal and circumferential landmarks within the ROI data set. The method and system automatically calculate circumferential and longitudinal segment boundaries, associated with wall segments of the heart, based on the apical, basal and circumferential landmarks. The method and system automatically assign segment identifiers (IDs) to the map points based on locations of the map points relative to the circumferential and longitudinal boundaries, the segment IDs associated with wall segments of the heart.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 14, 2019
    Assignee: Pacesetter Inc.
    Inventors: Hoda Razavi, Yelena Nabutovsky
  • Patent number: 10279178
    Abstract: An electrostimulation device comprises a hand-held electrostimulation generator receiving an input music signal and providing at an output a nerve electrostimulation signal modulated by the music signal, an electronic signal conduit having conductive leads conductively connected to the output of the electrostimulation generator, and an electrode coupler comprising an earbud.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: May 7, 2019
    Assignee: Neuvana, LLC
    Inventors: Richard Cartledge, Daniel Cartledge, Ami Brannon, Kermit Falk, Gregory L. Mayback
  • Patent number: 10272248
    Abstract: In some examples, controlling delivery of CRT includes delivering ventricular pacing according to a sequence of different values of at least one of A-V delay or V-V delay, and acquiring one or more electrograms from respective vectors. For each of the different values of the at least one of A-V delay or V-V delay, at least one of a QRS amplitude or a QRS area may be determined based on the one or more electrograms, and a target change in QRS amplitude or QRS area between adjacent ones of the values of the at least one of A-V delay or V-V delay of the sequence may be identified. In response to the identification of the target change, the implantable medical device may deliver the ventricular pacing at a value of the at least one of A-V delay or V-V delay determined based on the identification to provide CRT.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 30, 2019
    Assignees: Medtronic, Inc., Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Elien B. Engels, Kevin Vernooy, Alfonso Aranda Hernandez, Frits W. Prinzen, Jeffrey M. Gillberg