Abstract: Embodiments of the invention provide electrode assemblies and associated methods for the iontophoretic transdermal delivery of therapeutic agents. Many embodiments provide a corrosion resistant electrode for the iontophoretic transdermal delivery of various therapeutic agents. Such embodiments allow for the iontophoretic transdermal delivery of therapeutic agents such as iron compounds for prolonged periods without any substantial corrosion of the electrode, impedance increases or discoloration or irritation of the skin. Embodiments of the invention are particularly useful for the long term treatment of various chronic medical conditions such as iron deficient anemia.

Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

Abstract: An electrode assembly that includes an electrode configured to provide electrical contact with a subject's skin through a subject contact surface. The electrode includes an electrode base pad having a first contact surface on a side of the electrode opposite the subject contact surface. The electrode also includes a connector assembly configured to electrically connect the electrode to an external electrical apparatus to transfer electrical signals between the subject's skin and the external electrical apparatus. The connector assembly includes a housing having a second contact surface. The second contact surface is configured to be magnetically and electrically coupled to the first contact surface of the electrode base pad. The connector assembly also includes an electrical connector configured to connect the second contact surface to the external electrical apparatus.

Abstract: The invention is directed to an implant able insulated electrical circuit that utilizes polyparaxylylene, preferably as Parylene, a known polymer that has excellent living tissue implant characteristics, to provide for chronic implantation of conductive electrical devices, such as stimulators and sensors. The device is thin, flexible, electrically insulated, and stable after long exposure to living tissue. Layers of Parylene may be combined with layers of a polymer, such as polyimide, to yield greater design flexibility in the circuit. Multiple electrical conduction layers may be stacked in the circuit to increase packing density.

Abstract: The disclosure relates to a device for stimulating living tissue, comprising an array of stimulating microelectrodes that are placed in a defined configuration side by side and able to be selected by applying an electrical signal for stimulation by one of the microelectrodes. According to the disclosure, an additional conducting surface for application against the living tissue, is provided in the vicinity of a defined plurality of sections for local application of microelectrodes, connecting structures being provided for electrical connection between the zones, and the additional conducting surface being also connected to a lead and being formed so as to ensure local stimulation via a microelectrode.

Abstract: In one embodiment, a method of fabricating an implantable stimulation paddle comprises: providing a sheet of conductive material coupled to a first insulative layer; laser removing portions of the conductive material to form a pattern of conductive material, the pattern of conductive material including a plurality of isolated metal traces; providing a second insulative layer over the pattern of conductive material so that the pattern of conductive material is interposed between the first and second insulative layers; and exposing portions of the metal traces to form electrodes on the paddle for delivering electrical stimulation.

Abstract: In one implementation, a method of fabrication of stretchable electronic skin is provided. The method may include receiving an elastic material net. An elastic conductor mesh is formed on the elastic material net. A device is electrically bonded to the elastic conductor mesh. The implementation may further include forming a mold comprising a net pattern on a substrate and creating the elastic material net by coating the mold with an elastic material precursor, and then removing the elastic net from the substrate with the elastic conductor thereon. In one embodiment, a stretchable electronic skin including a net structure having a non-conducting elastic material with an elastic conductor mesh formed on the non-conducting elastic material, and a device electrically connected to the elastic conductor mesh.

Abstract: A medical electrode includes a moderately conductive flexible member having a top side and a bottom side with a plurality of highly conductive patterns disposed on the conductive flexible member bottom side in a spaced apart relationship. A moderately highly conductive layer disposed on the conductive flexible member bottom side and covering the conductive patterns, for adhering the electrode to a patient's skin. A connector is provided for establishing electrical contact with an external apparatus. The connector includes a leadwire having conductive portions in electrical communication with the conductive patterns and non-conductive portions between the conductive patterns. Control over conductivity between the leadwire conductive portion and the conductive pattern is provided.

Abstract: The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

Abstract: The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. In embodiments, the electrodes include a hydrogel in combination with a pH indicator which changes its color or opacity upon repeated use of the electrode, thereby indicating an appropriate time for changing or replacing the electrode.

Abstract: The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. The electrode includes a substrate and a conductive composition on at least a portion of a surface of the substrate. The conductive composition includes at least one hydrogel and at least one component that precipitates from the hydrogel after repeated use of the electrode, thereby providing an indication to replace the electrode.

Abstract: An electrotherapy electrode device. A generally thin, flexible top layer includes an aperture. A terminal is adjacent the top layer. The terminal has a generally planar shoulder, a post projecting from the shoulder, and a generally planar contact surface opposing the shoulder. The terminal includes a magnetic material. The post of the terminal extends through the aperture of the top layer and the shoulder of the terminal contacts the top layer.

Abstract: An electrode pad packaging system including an electrode pouch, an electrode pad (e.g., a defibrillation electrode pad), a wire and a shell is disclosed. The electrode pad is disposed at least partially within the electrode pouch. The wire extends from the electrode pad and, in a disclosed embodiment, at least a portion of the wire is attached to the shell. The shell is disposed in mechanical cooperation with the electrode pouch (e.g., the shell is secured to a portion of the electrode pouch). The shell includes a valve thereon that is configured to allow air to exit the electrode pouch. The valve may be configured to prevent air from entering the electrode pouch. A method of packaging an electrode pad is also disclosed. The method includes providing an electrode pouch, an electrode pad, a wire and a shell. A valve on the shell allows air to exit the electrode pouch.

Abstract: A selective nerve stimulation patch includes a substrate having a top surface and a bottom surface, integrated components overlying the top surface of the substrate and being electrically interconnected with one another for generating at least one nerve stimulating signal, electrodes integrated into the substrate and exposed at the bottom surface thereof for applying the at least one nerve stimulating signal to a target nerve, a waterproof, breathable cover overlying the substrate and the integrated components, and a support flange surrounding the substrate and coupling the cover and the substrate together. The support flange has a top surface that slopes downwardly toward an outer perimeter thereof, and at least a portion of the cover conforms to the sloping top surface of the support flange. In one embodiment, the patch generates a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve.

Abstract: A disposable tab electrode has core elements that include an adhesive conductive laminate layer and a logo sticker layer with a penetrating hole for contacting a sensor electrode. A protecting film is put around both ends of the core elements. As a result, the disposable tab electrode can be made inexpensively, stored hygienically for a long time and used easily. A lead wire for connecting to the tab electrode has a projection on one end of a sensor electrode that is adhered onto the conductive laminate layer of the disposable tab electrode. The projection is fixed to the lead wire body by a fixing member. As a result, expensive Ag—AgCl electrode sensors can be used repeatedly. The lead wire can have a nipper self-contained or integrated with the lead wire body to prevent the lead wire from separating from the disposable tab electrode during use.

Abstract: An electrosurgical return electrode is disclosed. The return electrode includes a first and second flexible conductive material layers and a material layer disposed between the first and second conductive material layers. The material layer is transitionable between a solid state and a non-solid state, the material layer is also configured to melt upon an increase in temperature beyond a predetermined threshold, thereby increasing conductivity between the first and second conductive material layer.

Abstract: An electrosurgical return electrode is disclosed. The return electrode includes a conductive pad having one or more temperature monitoring zones and a patient-contacting surface configured to conduct electrosurgical energy and a temperature sensing circuit coupled to the conductive pad. The temperature sensing circuit includes at least one diode disposed within the at least one temperature monitoring zone, the at least one diode having a predetermined forward voltage drop that is indicative of temperature of at least one temperature monitoring zone.

Abstract: Present invention is a method of improving circadian rhythms in blind people by stimulation the visual neural system. Ideally a retinal prosthesis of the type used to restore vision can be used to restore normal circadian rhythms. Additionally, brightness on the prosthesis can be increased in the morning and decreased in the evening to stimulate normal Circadian rhythms. Alternatively, if a retinal prosthesis is not preferable, the retina can be stimulated externally, during the day and not at night. While such eternal stimulation can not produced artificial vision, it can stimulate normal circadian rhythms.

Abstract: A bioelectrode comprising a skin-side, electrically conducting adhesive layer (7) and a flexible electrical connecting cable (4) which in an electrically insulating cable sheath (5) includes at least one electrical conductor (6), preferably in the form of a braid comprising a plurality of individual wires or conducting individual fibers, wherein the electrode-side end (4a) of the connecting cable (4) is arranged between two thermoplastic layers (2, 3) which are welded together at least region-wise, wherein both thermoplastic layers (2, 3) are electrically conducting and are electrically connected to the electrical conductor (6) of the connecting cable (4).

Abstract: As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

Abstract: A medical electrode is provided for detecting and transmitting electric pulses from the body surface of a patient to an electric pulse processor. The medical electrode includes an outer carrier and at least one inner carrier (3, 3?, 3?). The outer carrier and the inner carrier are connected at a defined number of geometrically distributed points (2). The points (2) form an outer edge (4) of the inner carrier and are perforated, so that the outer carrier and the inner carrier can be separated at these points (2). An adhesion area (5) is formed on the underside of the outer carrier (1) and of the inner carrier for adhering the medical electrode to the patient body surface. A contact element (7) is provided with a conductive area arranged concentrically to the contact element (7) for establishing contact with the body surface of the patient. The contact element (7) and the conductive area (8) are arranged within the inner carrier.

Abstract: A complementary drug delivery sheath for implantable medical devices. The complementary drug delivery sheath is covered, impregnated or otherwise carries one or more drugs. The complementary drug-delivery sheaths are manufactured separately from to the implantable device and are operationally combined with the device subsequent to the device's manufacture and/or sterilization. For example, embodiments of the complementary drug-delivery sheaths may be configured, for example, to attain an implanted position adjacent to one or more surfaces of an implantable medical device. In certain embodiments, the sheath is configured in the form of a glove, pocket, pouch, or the like to receive and to partially or completely wrap around or envelop an implantable medical device. Embodiments of the complementary drug delivery sheath may be implanted into the recipient prior to, concurrently with, or subsequent to the implantation of the implantable medical device.

Abstract: A medical electrode for bonding to the skin of a patient comprises a support which adheres to the skin and a holding element for at least one electrically conducting connection piece, wherein the skin side of the connection piece is covered with an electrically conducting gel, in particular in a sponge, wherein the gap on the skin side between the holding element and the electrically conducting connection piece is closed by a sealing element which is preferably ring-like.

Abstract: An electrode including a non-conductive substrate having a top surface and at least one channel extending therethrough, an electrically conductive trace material positioned adjacent a portion of the top surface of the non-conductive substrate and extending through the channel, and adapted for electrically coupling to a power source, and second and third electrically conductive materials that are inert or more corrosion resistant than the trace material. The second material is positioned adjacent to and entirely covering a top surface of the trace material, and the third material is positioned adjacent to and entirely covering a top surface of the second electrically conductive material, and covers a portion of a top surface of the non-conductive substrate surrounding the second electrically conductive material. The electrode further includes a conductive hydrogel positioned adjacent to a portion of a top surface of the third electrically conductive material, but laterally offset from the trace material.

Abstract: In one embodiment, a method of fabricating an implantable stimulation paddle comprises: providing a sheet of conductive material coupled to a first insulative layer; laser removing portions of the conductive material to form a pattern of conductive material, the pattern of conductive material including a plurality of isolated metal traces; providing a second insulative layer over the pattern of conductive material so that the pattern of conductive material is interposed between the first and second insulative layers; and exposing portions of the metal traces to form electrodes on the paddle for delivering electrical stimulation.

Abstract: Therapeutic devices for stimulation of living tissue are provided. Multimodal stimulation may be mechanical, electrical, chemical, sensory and combinations thereof. The devices have a matrix sufficiently elastic so that when attached to the tissue, the matrix is capable of applying force upon the tissue and compliantly responding to force resultant from motion of the tissue. The devices also have an electrically conductive region contained within the matrix, so that, selectable locations of the device are capable of being in electrical communication with a power source and with the tissue. Methods of stimulating tissue as well as methods of making the devices are also provided.

Abstract: Present invention is a method of improving circadian rhythms in blind people by stimulation the visual neural system. Ideally a retinal prosthesis of the type used to restore vision can be used to restore normal circadian rhythms. Additionally, brightness on the prosthesis can be increased in the morning and decreased in the evening to stimulate normal Circadian rhythms. Alternatively, if a retinal prosthesis is not preferable, the retina can be stimulated externally, during the day and not at night. While such eternal stimulation can not produced artificial vision, it can stimulate normal circadian rhythms.

Abstract: There is disclosed a system of electrodes used for transdermal conduction of electric signals and a method of use thereof, the said system comprising a plurality of electrode parts (17, 58, 58?) connected by means of electrical conductors (17?, 68) to electric impedance tomography apparatuses, as well as other devices, the said parts being secured to the outer side (15a, 54a, 54?a) of a flexible and porous blade (15, 54c, 51?) coated on both sides thereof by layers of electrically conductive and adhesive materials, such electrically conductive materials being in mutual contact through the pores (74) of the said blade, the inner face of the latter being removably secured, by means of adhesion, to the skin of the patient (65). The invention comprises means for positioning the said electrode parts, as well as means for external protection thereof and of their respective conductors.

Abstract: An electronic low-frequency pulse patch of a one-piece structure is disclosed, which has a power supply and a circuit capable of outputting positive and negative current pulses concealed therein, and in which, without use of a flexible ribbon cable set and an additional fastener, a host unit and a coupling conductive patch unit assembly are joined together with the appearance to form a one-piece seamless water-proof structure for use as a self-adhesion patch device capable of generating a low-frequency pulse output.

Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced.

Abstract: A method of forming a device, such as an electrode array for a cochlear implant. The method comprises a step of forming a predetermined pattern of relatively electrically conductive regions and relatively electrically resistive regions in a sheet of biocompatible electrically conductive material, such as platinum foil. The method can comprise a step of working on the sheet to remove predetermined portions therefrom to form the one or more discrete relatively conducting regions. The step of working on the sheet can comprise embossing the sheet, cutting or slicing the sheet, or using electrical discharge machining (EDM) to remove unwanted portions of the sheet, the EDM equipment having a cutting tool comprising an electrode.

Abstract: An elongate electrode carrier member including a longitudinally-extending central region, two side regions laterally extending from opposing sides of the central region, a lateral surface defined by the central and side regions together forming a convex circumferential surface, a medial surface defined by a convex surface of the central region and a concave surface for each of the side regions, a plurality of longitudinally-spaced electrodes disposed on or in the convex surface of the central region of the medial surface, and a support structure including a plurality of longitudinally extending wires each connected to one or more of the electrodes, wherein a subset of the plurality of wires is disposed in the central region and at least one of the plurality of wires is disposed in one of the side regions.

Abstract: A copper screen placed between two one inch foam pads and covered with crushed sapphire crystal is connected to an activated Tesla coil. This leads to increased telomere length in normal white blood cells and can be used to increase the reproductive capacity of cells and to delay the onset of cellular senescence.

Abstract: A textile for providing traditional Chinese medicine therapy to a wearer using electronic stimulation includes at least two conductive paths that are made from conductive textile material, the conductive paths are separated by nonconductive textile material, at least one pair of electrodes attach to the conductive paths corresponding to specific part of body or acupoints according to traditional Chinese medicine theory, and an electronic stimulation signal controller configured to conduct electronic stimulation signals to the electrodes via the conductive paths.

Abstract: An electrode array has a flexible body supporting a plurality of electrodes. Each electrode comprises an exposed connector pad at the upper end of the body, an exposed recording/stimulating pad at the lower end of the body, and a conductor located within the body and electrically connecting the connector pad and the recording/stimulating pad. In one embodiment the electrode array has an elongated recording/stimulating portion coiled or folded to distribute the exposed recording/stimulating pads in three dimensions. An implantation method employs an introducer with a helical portion to which an end of the flexible electrode is attached. The helical portion straightens to pass through a small-diameter cannula and then resumes its helical configuration to place the recording/stimulating portion of the attached electrode in a helix within the patient's tissues.

Abstract: The set for the electrical stimulation of a patient, comprises a backing, at least one electrically active zone and a wire connected to said electrically active zone for connection to a stimulator. Said backing has the shape of a bandage or of a plaster.

Abstract: We disclose an electrode assembly comprising a ribbon electrode having a first surface and a second surface; a plurality of bosses disposed on the second surface of the ribbon electrode, wherein each boss has a third surface substantially not in contact with the second surface of the ribbon electrode and at least one boss is electrically conducting; and an insulator contacting substantially the entire second surface of the ribbon electrode and substantially the entire third surface of each boss; wherein the insulator is substantially not in contact with the first surface of the ribbon electrode. We also disclose an implantable medical device system comprising an implantable medical device for generating an electrical signal; an electrode assembly as described; and a lead wire electrically coupled to both the implantable medical device and at least one electrically conducting boss of the electrode assembly.

Abstract: A medical electrode includes a moderately conductive flexible member having a top side and a bottom side with a plurality of highly conductive patterns disposed on the conductive flexible member bottom side in a spaced apart relationship. A moderately highly conductive layer disposed on the conductive flexible member bottom side and covering the conductive patterns, for adhering the electrode to a patient's skin. A connector is provided for establishing electrical contact with an external apparatus. The connector includes a leadwire having conductive portions in electrical communication with the conductive patterns and non-conductive portions between the conductive patterns. Control over conductivity between the leadwire conductive portion and the conductive pattern is provided.

Abstract: In an embodiment, an article includes a primary surface, and a pattern of spaced dissimilar materials, on the primary surface. The pattern is to spontaneously produce electrical surface currents when brought into contact with an electrically conducting solution.

Abstract: A medical electrode assembly can be substantially transparent or translucent to visible, infrared and/or ultraviolet light so that light rays emitted by a phototherapy device can shine through and pass transversely across every layer of the medical electrode assembly to impinge upon the skin of the patient to which the assembly is attached. This includes an area of skin located directly underneath the medical electrode assembly and thereby enables a combination of therapies including one or more of electrotherapy and phototherapy. The upper and lower exterior exposed faces of the medical electrode can have tacky, self-adhesive surfaces.

Abstract: The invention presents techniques for making the operation of an automated external defibrillator easier to understand for an operator. The automated external defibrillator includes defibrillation electrodes packaged in a sealed, easy-to-open pouch. Visual cues such as instructive pictures show the operator how to open the pouch, retrieve the defibrillation electrodes and correctly position the electrodes on a patient's chest.

Abstract: The present invention provides a double-sided patch comprising a first side and a second side, wherein each of the first side and the second side of the double-sided patch is configured as a treatment patch. Furthermore, the present invention provides a double-sided patch, wherein each side of the double-sided patch shares at least one common patch component with the other side of the double-sided patch.

Abstract: Embodiments of the invention include a method and device for promoting healing of an injury in a living being. The embodiments comprise an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.

Abstract: A medical electrode includes a moderately conductive flexible member having a top side and a bottom side with a connector and contact with a flexible member top side for establishing electrical contact with an external apparatus. A non-conductive flexible sheet covers the conductive flexible member top and the connector and a highly conductive ink pattern is disposed on a conductive flexible member bottom side. A moderately high conductive hydrogel adhesive disposed on the conductive flexible member bottom side and cover the conductive ink pattern is provided for adhering electrode to a patients' skin.

Abstract: An electrode arrangement for applying electrical signals to skin of an animal comprising a flexible electrically non-conductive substrate, at least one electrode provided on a first surface of the substrate for applying electrical signals to the skin when placed on the skin, at least one connector connected to a respective electrode for providing electrical signals to the respective electrode and an electrically non-conductive sealing arrangement connected to the substrate for sealing the substrate and the skin to prevent ingress of moisture to the at least one electrode and to the at least one connector at the connection to the respective electrode. The or each electrode comprises a plurality of spaced electrically conductive elements to allow flexion of the electrode arrangement and electrically conductive material between the plurality of spaced electrically conductive elements to form a two-dimensional electrically conductive path across at least a portion of the first surface of the substrate.

Abstract: A medical electrode, and a method of making a medical electrode. The electrode comprises an electrode member having a top face and a bottom face; disconnected regions of electrically conductive material in electrical contact with the top face of the electrode member, patient contacting layer and an electrical connector in electrical contact with the disconnected regions. The disconnected regions reduce patient skin irritation and burning while optimizing electrical impedance of the electrode.

Abstract: A transcutaneous electric nerve stimulator (TENS) electrode that comprises a conductive layer containing both an inner perimeter(s) and an outer perimeter(s) is disclosed. When used with TENS treatment protocols and devices or other treatment/therapy methods, the electrode can induce a higher rate of A fiber firing by creating baffling to balance the electrical current flowing through the electrodes and induces superior analgesia.

Abstract: A return pad cable connector, in accordance with the present disclosure, for use with a disposable return pad, includes a cord having a conductive wire disposed therethrough which conductive wire interconnects the return pad cable connector to an electrosurgical energy source. The return pad further includes a connector operatively coupled to the cord, the connector having a conductive surface which is selectively engageable with a corresponding conductive surface disposed on the return pad, the conductive surface of the connector including a conductive adhesive disposed thereon and a non-conductive adhesive disposed above the periphery of the conductive surface of the connector for engagement with a corresponding non-conductive adhesive disposed above the periphery of the conductive surface of the return pad. The connector can include a magnet for magnetically coupling the connector to the conductive surface disposed on the return pad.

Abstract: As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

Abstract: A myocardial infarction patch for placement over a myocardial infarction includes an electroactive polymer (EAP) structure. Varying electricity supplied to the EAP structure causes the patch to expand and contract over the myocardial infarction. The expansion and contraction of the patch can be coordinated with the expansion and contraction of the heart. The electricity is provided to the EAP via a pacemaker, defibrillator, ICD or similar pulse-generating device. Causing the patch to expand and contract against the myocardial infarction can improve the ejection fraction of the heart.