Stimulating Reproductive Organ Patents (Class 607/39)
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Patent number: 7797049Abstract: In general, the invention provides a transurethral ablation device comprising an electrode for delivery of neurostimulation therapy to a patient to prevent or alleviate pain experienced during the course of a transurethral ablation procedure. The device may include a conductive ablation needle that delivers electrical current for ablation of prostate tissue, as well as neurostimulation current to prevent or alleviate pain encountered in response to the ablation current. In this sense, the ablation needle is integrated with a neurostimulation electrode. Alternatively, the device may incorporate a dedicated neurostimulation electrode independently of the ablation needle, either on the needle or on a catheter body that carries the needle.Type: GrantFiled: December 28, 2007Date of Patent: September 14, 2010Assignee: Medtronic, Inc.Inventors: Mark A. Christopherson, John M. Swoyer
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Patent number: 7763034Abstract: The disclosure is directed to a method and tool for implanting a stimulation lead or other medical device adjacent a pudendal nerve. The tool includes a shaped needle that enters a patient and passes through an obturator foramen passage in a pelvis. A physician places a tip of the tool at the pudendal nerve and performs test stimulation to confirm an effective stimulation location. A shape memory cannula initially covering the needle remains at the pudendal nerve when the physician removes the tool. The cannula deforms to follow the curve of the pudendal nerve once the needle is removed, and a lead is inserted into the cannula and secured at the pudendal nerve placement site. This method may provide an easier and more consistent procedure for implanting the stimulation lead near the pudendal nerve.Type: GrantFiled: January 24, 2006Date of Patent: July 27, 2010Assignee: Medtronic, Inc.Inventors: Steven W. Siegel, Eric H. Bonde, Martin T. Gerber
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Publication number: 20100174137Abstract: The present invention generally relates to systems capable of providing and delivering electric potential to a pelvic (i.e., vaginal) structure of a female to cause contraction of pelvic muscles and/or stimulation of pelvic nerves. More particularly, the present invention relates to various systems which include various power members and electrode members, where such power members are capable of providing electric power for such potential from various sources and where such electrode members are capable of delivering the potential along a preset direction or multiple directions. Therefore, such systems may also induce contraction of the pelvic muscles and/or stimulation of the pelvic nerves in a desirable order. Such systems may further induce the muscle contraction and/or nerve stimulation in synchronization with dynamic patterns of various variables of the system.Type: ApplicationFiled: January 6, 2009Publication date: July 8, 2010Inventor: Youngtack Shim
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Patent number: 7734355Abstract: Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.Type: GrantFiled: January 23, 2002Date of Patent: June 8, 2010Assignee: Bio Control Medical (B.C.M.) Ltd.Inventors: Ehud Cohen, Yossi Gross, Shai Ayal
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Publication number: 20100094372Abstract: Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.Type: ApplicationFiled: October 15, 2009Publication date: April 15, 2010Inventors: Warren M. GRILL, Kenneth J. GUSTAFSON, Graham H. CREASEY
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Patent number: 7676269Abstract: Methods are provided for treating a subject for a fertility condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated to increase the sympathetic activity/parasympathetic activity ratio in a manner that is effective to treat the subject for the condition. Embodiments of the subject invention include modulating a subject's autonomic nervous system using electrical energy and/or one or more pharmacological agents. The subject methods find use in the treatment of a variety of different fertility conditions. Also provided are kits for use in practicing the subject methods.Type: GrantFiled: December 29, 2003Date of Patent: March 9, 2010Assignee: Palo Alto InvestorsInventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee
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Patent number: 7660631Abstract: Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.Type: GrantFiled: April 22, 2005Date of Patent: February 9, 2010Assignee: Boston Scientific Neuromodulation CorporationInventors: Todd K Whitehurst, James P McGivern
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Publication number: 20100016657Abstract: The present invention relates to an apparatus and method for treating erectile dysfunction. One of the causes of erectile dysfunction is venous leakage, where one or more veins carrying the blood from the penis are unable to retain sufficient blood within the penis to maintain erection. Embodiments of the present invention propose implanting contractile tissue sphincters around the base of the penis and/or around one or more veins, and stimulating the contractile tissue to contract when an erection is required to be maintained. Stimulation is provided by an implantable stimulator.Type: ApplicationFiled: April 24, 2007Publication date: January 21, 2010Applicant: Continence Control Systems International Pty LtdInventors: Peter Robertson, Anthony Clyde Neason Stephen
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Patent number: 7647112Abstract: Devices and methods are provided for electrically stimulating a predetermined body part of a mammal. The method includes placing at least one electrode in proximity to the mammal's skin, injecting an electrically conductive gel into the body of the mammal so as to form a conductive gel pathway extending at least partially along a distance between the at least one electrode and the predetermined body part, and stimulating the predetermined body part by applying an electrical signal via the electrode that travels, at least in part, through the conductive gel pathway.Type: GrantFiled: January 31, 2006Date of Patent: January 12, 2010Assignee: Ethicon, Inc.Inventors: Michael R. Tracey, Anthony DiUbaldi, Douglas B. Johns
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Patent number: 7627383Abstract: Exemplary implantable stimulators for stimulating a stimulation site within a patient include an electronic module configured to generate stimulation and a housing configured to house the electronic module. The housing has a shape allowing the a stimulator and a surgical device to be accommodated together within an insertion tool used to insert the stimulator into the patient. Exemplary methods of stimulating a stimulation site within a patient include generating stimulation with an electronic module and housing the electronic module in a housing. The housing has a shape allowing the housing and a surgical device to be accommodated together within an insertion tool used to insert the housing into the patient.Type: GrantFiled: March 15, 2005Date of Patent: December 1, 2009Assignee: Boston Scientific Neuromodulation CorporationInventors: Matthew I. Haller, Jay Daulton, Todd K. Whitehurst, Rafael Carbunaru
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Patent number: 7623924Abstract: Methods and devices for electrically stimulating nerves and organs to induce and modulate the production of hormones according to desired hormone production patterns and hormone level patterns to treat gynecological conditions. Such methods and devices may be used to treat or alleviate the symptoms of menopause. In addition, such methods and devices may be used for birth control.Type: GrantFiled: August 30, 2005Date of Patent: November 24, 2009Assignee: Leptos Biomedical, Inc.Inventor: Hugh Louis Narciso, Jr.
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Patent number: 7623923Abstract: The disclosure describes a tube pressure sensor to measure penile tumescence which may be used in a therapeutic penile tumescence control system. The system senses penile pressure and sends the information to a stimulator that is capable of stimulation therapy to control an erectile state, thus treating sexual dysfunction or, more specifically, erectile dysfunction. Measuring penile tumescence pressure is accomplished through the use of a tube placed within the urethra of the penis and attached to a module implanted within the bladder. Pressure on the tube generates an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves that stimulate erections. An external device may be used to wirelessly send information to the implanted stimulator to start or stop stimulation in order for the patient to conduct normal sexual activity.Type: GrantFiled: April 28, 2005Date of Patent: November 24, 2009Assignee: Medtronic, Inc.Inventors: Martin T. Gerber, Keith A. Miesel
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Patent number: 7623925Abstract: Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.Type: GrantFiled: May 31, 2005Date of Patent: November 24, 2009Assignee: Case Western Reserve UniversityInventors: Warren M Grill, Kenneth J Gustafson, Graham H Creasey
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Publication number: 20090259095Abstract: A device for treating hypo-orgasmia or anorgasmia is described. Energy transfer leads that transfer energy may be implanted proximate to one or more of the dorsal nerves of the clitoris in a female. A signal generator may be used to receive a signal (such as a signal from a handheld remote) to begin the transfer of energy via the two energy transfer leads. The signal generator may then generate pulses either in a predetermined manner or a dynamic manner.Type: ApplicationFiled: November 12, 2008Publication date: October 15, 2009Inventors: Nicholas Sieveking, Michael Stephanides, Carl Zimmerman
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Publication number: 20090250068Abstract: There is provided a method for controlling a flow of fluid in the vas deferens in order to obtain a controlled male contraception. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the flow vas deferens, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the flow in the vas deferens. The method can be used for restricting or stopping the flow in the vas deferens, or for actively moving the fluid in the vas deferens, with a low risk of injuring the organ.Type: ApplicationFiled: October 14, 2008Publication date: October 8, 2009Inventor: Peter Forsell
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Publication number: 20090247818Abstract: There is provided a method for treating sexual dysfunction of a female patient comprising stimulating at least one portion of the patient's female erectile tissue to at least restrict the blood flow leaving the erectile tissue to obtain engorgement with blood of the female erectile tissue. To improve the erection effect the method further comprises gently constricting the erectile portion to restrict the venous blood flow in the erectile portion, and then stimulating the constricted erectile portion to cause contraction of the erectile portion to at least further restrict the blood flow leaving the erectile tissue to obtain engorgement with blood of the female erectile tissue.Type: ApplicationFiled: October 14, 2008Publication date: October 1, 2009Applicant: Milux Holding S.A.Inventor: Peter Forsell
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Publication number: 20090248109Abstract: There is provided a method for treating a male impotent patient comprising stimulating at least one portion of the patient's normal penile tissue or the prolongation thereof to at least restrict the blood flow leaving the penis to achieve erection. To improve the erection effect the method further comprises gently constricting the penile portion or the prolongation thereof to restrict the venous blood flow in the penile portion, and then stimulating the constricted penile portion to cause contraction of the penile portion to at least further restrict the blood flow leaving the penis to achieve erection.Type: ApplicationFiled: October 14, 2008Publication date: October 1, 2009Applicant: Milux Holding S.A.Inventor: Peter Forsell
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Patent number: 7577476Abstract: A system and method are provided for transducing vaginal conditions, affecting vaginal or body conditions, and/or stimulating perineal musculature and nerves. A separate, portable, non-implanted intravaginally containable combination probe and transceiver is provided that can sense vaginal conditions, can deliver signals or medication, and/or can stimulate perineal musculature and nerves. This probe unit is provided with 2-way wireless communication for transmitting information that is transduced and for receiving control and programming signals. In addition, a separate combination controller and transceiver is provided for wirelessly sending signals to the probe unit and for receiving signals therefrom. A real time wireless signal feedback loop is thus provided between the controller and the probe and/or external devices, networks and databases.Type: GrantFiled: October 26, 2001Date of Patent: August 18, 2009Assignee: Athena Feminine Technologies, IncInventors: Joel S. Hochman, George Sarkis
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Patent number: 7561918Abstract: A method (and associated apparatus) of providing electrical neurostimulation therapy to a patient using an implanted neurostimulator comprises (a) delivering an electrical stimulation to a nerve and (b) determining whether a predetermined condition has occurred as a result of the stimulation. The method further comprises (c) if the predetermined condition has not occurred, adjusting one or more stimulation parameters; and (d) repeating (a), (b), and (c) until the predetermined condition occurs.Type: GrantFiled: January 28, 2005Date of Patent: July 14, 2009Assignee: Cyberonics, Inc.Inventors: Randolph K. Armstrong, Scott A. Armstrong
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Publication number: 20090036945Abstract: Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The methods and apparatus also can be used to control pain in the lower pelvic region, for example and without limitation, interstitial cystitis. The methods and apparatus also can be used to increase sexual sensation.Type: ApplicationFiled: August 1, 2008Publication date: February 5, 2009Inventors: Michael B. Chancellor, Changfeng Tai
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Publication number: 20090018620Abstract: The present invention relates to a method for eliciting ejaculation in a male individual, comprising delivering one or more stimulation pulses to lumbar spinothalamic (LSt) cells.Type: ApplicationFiled: October 9, 2007Publication date: January 15, 2009Applicant: PELVIPHARMInventors: Jacques Bernabe, Aren Borgdorff, Francois Giuliano
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Publication number: 20080287733Abstract: An apparatus for sexual stimulation in a safe and convenient manner is disclosed. The present invention provides for the in-out motion of an attachment that simulates a penis. The present invention also provides for a vibration mechanism to vibrate the attachment during use. The stroke rate is adjustable by the user. Furthermore, the vibration frequency, and stroke depth are also adjustable by the user during use. The present invention makes use of a mechanical articulating joint, generically known as a spherical rod end or Heim joint for the mounting of an attachment.Type: ApplicationFiled: May 14, 2007Publication date: November 20, 2008Inventor: Donald F. Robinson
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Patent number: 7437194Abstract: The invention is directed to techniques for providing electrical stimulation to the prostate gland of a patient. In particular, various techniques are described for providing such stimulation in order to treat sexual dysfunction, benign prostatic hyperplasia (BPH), or other disorders. In some embodiments, the stimulation may be provided to the prostate gland to cause erection or ejaculation in order to treat various sexual dysfunctions. In other embodiments, the stimulation may comprise a training sequence of pulses selected to train and modify the cellular structure of the prostate gland in order to treat BPH or similar prostate disorders.Type: GrantFiled: October 31, 2003Date of Patent: October 14, 2008Assignee: Medtronic, Inc.Inventors: Thomas R. Skwarek, Martin T. Gerber
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Publication number: 20080183236Abstract: Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of tissue volumes at two or more locations adjacent sacral nerves or portions thereof, and/or pudendal nerves or portions thereof. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the respective tissue volumes in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and/or fecal voiding dysfunctions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.Type: ApplicationFiled: March 31, 2008Publication date: July 31, 2008Applicant: Medtronic, Inc.Inventor: Martin T. Gerber
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Publication number: 20080161874Abstract: Systems and methods screen and/or treat disorders of the body using neurostimulation. A trial system implants a temporary or permanent percutaneous lead and couples the lead to an external pulse generator. The external pulse generator supplies a prescribed stimulation regime through the lead to a targeted tissue region. If an improvement in the treated disorder is achieved, use of the trial system may be continued, or an implantable system may be implanted.Type: ApplicationFiled: October 31, 2007Publication date: July 3, 2008Inventors: Maria E. Bennett, Julie Grill, Tina E. Lechman, Joseph J. Mrva, Robert B. Strother, Geoffrey B. Thrope, Therese M. Zmina, Steven M. Galecki, Danny R. Pack
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Patent number: 7369894Abstract: Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of tissue volumes at two or more locations adjacent sacral nerves or portions thereof, and/or pudendal nerves of portions thereof. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the respective tissue volumes in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and/or fecal voiding dysfurictions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.Type: GrantFiled: April 30, 2004Date of Patent: May 6, 2008Assignee: Medtronic, Inc.Inventor: Martin T. Gerber
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Publication number: 20080103544Abstract: A method for treating female sexual dysfunction by subcutaneous electrical stimulation of a peripheral nerve innervating at least a portion of the vulva is disclosed. A lead is placed subcutaneously over a peripheral nerve that innervates at least a portion of the vulva and clitoris. The peripheral nerve is electrically stimulated to cause paresthesia. The method encompasses subcutaneous placement of an electrical lead near any peripheral nerve innervating at least a portion of the vulva and subsequent electrical stimulation of the nerve to cause paresthesia. Further, a method for treating intractable pain of the vulva using percutaneous and subcutaneous peripheral nerve electrostimulation techniques is disclosed.Type: ApplicationFiled: October 28, 2006Publication date: May 1, 2008Inventor: Richard L. Weiner
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Patent number: 7343202Abstract: Systems and methods provide a stimulation electrode assembly comprising an elongated lead sized and configured to be implanted within an adipose tissue region. The lead includes an electrically conductive portion to apply electrical stimulation to nerve or muscle in the adipose tissue region and at least one expandable anchoring structure deployable from the lead to engage adipose tissue and resist dislodgment and/or migration of the electrically conductive portion within the adipose tissue region.Type: GrantFiled: June 10, 2005Date of Patent: March 11, 2008Assignee: NDI Medical, LLC.Inventors: Joseph J. Mrva, Robert B. Strother, Geoffrey B. Thrope, Julie Grill, Maria Bennett
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Patent number: 7330762Abstract: A method and system for providing pulse electrical stimulation to at least one of sacral plexus or its branches or portions, inferior hypogastric plexus or its branches or portions, superior hypogastric plexus or its branches or portions in a patient, to provide therapy for one of erectile/sexual dysfunction, prostatitis, pelvic pain, and pain originating from prostatitis pathology. The stimulation system comprises both implanted and external components.Type: GrantFiled: June 7, 2004Date of Patent: February 12, 2008Assignee: Neuro and Cardiac Technologies, LLCInventors: Birinder R. Boveja, Angely Widhany
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Patent number: 7328068Abstract: Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of the pudendal or other nerves, and optional means for delivering drugs in association therewith. A method of precisely positioning and implanting a medical electrical lead so as to provide optimal stimulation of the pudendal nerve or a portion thereof is also described. Placement of a stimulation lead next to or on the pudendal nerve may be performed using conventional prior art techniques through gross anatomical positioning, but usually does not result in truly optimal lead placement. One method of the present invention utilizes neurophysiological monitoring to assess the evoked responses of the pudendal nerve, and thereby provide a method for determining the optimal stimulation site.Type: GrantFiled: November 26, 2003Date of Patent: February 5, 2008Assignee: Medtronic, Inc.Inventors: Michele Spinelli, Sylvia Malaguti, Martin T. Gerber, Gianluca Giardiello
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Patent number: 7328069Abstract: Described are devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of the pudendal nerves, and means for delivering one or more drugs in association with such electrical stimulation therapies. One or more electrical stimulation signals are applied, and one or more drugs are infused, injected or otherwise administered, to appropriate portions of a patient's pelvic floor and the pudendal nerves or portions thereof in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary voiding dysfunction, fecal voiding dysfunction, constipation, stress incontinence, urge incontinence, urinary retention disorder, sexual dysfunction, orgasmic dysfunction, erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.Type: GrantFiled: April 30, 2004Date of Patent: February 5, 2008Assignee: Medtronic, Inc.Inventor: Martin T. Gerber
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Patent number: 7203548Abstract: Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.Type: GrantFiled: June 20, 2002Date of Patent: April 10, 2007Assignee: Advanced Bionics CorporationInventors: Todd K Whitehurst, James P McGivern, Rafael Carbunaru, Matthew I Haller, Tom Xiaohai He, Kerry Bradley
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Patent number: 7177703Abstract: A method and system for providing electrical pulses for neuromodulating sacral nerves of a patient utilizing an implantable stimulator. The implantable stimulator comprising a pulse generator module and a stimulus receiver module for coupling with an external stimulator. Control circuitry ensures selective operation of one pulse generator module. The external stimulator comprises a telemetry module for remotely activating (or de-activating) programs over the internet, to arrive at the optimal program for each patient. Once the optimal “dose” is titrated using the external stimulator, the implanted pulse generator can then be programmed to such parameters. The external stimulator in conjunction with the implanted stimulus receiver can override the implanted pulse generator, to provide extra dose of therapy or to conserve the implanted battery. The external stimulator is also networked to other computers.Type: GrantFiled: May 11, 2003Date of Patent: February 13, 2007Inventors: Birinder R. Boveja, Angely Widhany
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Patent number: 7155285Abstract: Alpha rhythm brain waves are related to mental and physical relaxation and healing. Based on the studies of bionics, this invention relates to inducing oscillatory alpha rhythm to the human body, and relates to the means of the alpha rhythm machine applied to human body. Research of the alpha rhythm of human brain wave patterns and EEG has indicated special recorded data of alpha rhythm brain waveform which is the bearing of the proper biological information of relaxing and healing. The apparatus was developed and built to construct and release the simulated human brain alpha rhythm signals which are at the frequencies ranging 8 Hz–14 Hz and at the amplitudes altered in high or low. Both the frequencies and the amplitudes are changing at a non-stationary random order in the duration of the event, respectively.Type: GrantFiled: December 11, 2003Date of Patent: December 26, 2006Inventors: Xiaoming Wang, Huijian Zou, Wei Chen
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Patent number: 7127287Abstract: A multi-purpose, functional electrical stimulation (FES) system 10 includes an implantable stimulator unit 12 for stimulating a plurality of different sites in a patient's body 14. A transmitter 20 is arranged externally of the patient's body 14 for supplying signals transcutaneously to the stimulator unit 12. A controller 16 is in communication with the transmitter 20. At least one implantable switching node 26 has an input terminal 30 in electrical communication with the stimulator unit 12 and a plurality of output terminals to each of which one of a further switching node 26 and a stimulating element 24 is connected. The switching node 26 including addressing circuitry 44 for switching at least one output terminal into electrical connection with the input terminal 30 of the switching node 26 in response to a control signal received from the controller 16 via the stimulator unit 12.Type: GrantFiled: February 10, 2003Date of Patent: October 24, 2006Assignee: Neopraxis Pty LimitedInventors: Michael Duncan, Ian Bruinsma, Zoran Milijasevic, Andrew Barriskill
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Patent number: 7120497Abstract: A method of promoting the healing of a lesion in a smooth muscle, comprising selecting a smooth muscle portion having a lesion and applying a non-excitatory electrical field to the portion, which field reduces the mechanical activity of the portion.Type: GrantFiled: October 29, 2002Date of Patent: October 10, 2006Assignee: Metacure NVInventors: Shlomo Ben-Haim, Nissim Darvish, Yuval Mika, Maier Fenster, Bella Felzen, Isaac Shemer
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Patent number: 7047078Abstract: Systems and methods control physiological functions of the urinary tract using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve. The systems and methods apply an electrical signal to the electrode at a selected frequency to stimulate the targeted component. The selected frequency is a first frequency or range of frequencies for achieving a first physiologic response (e.g., controlling urinary continence) and a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).Type: GrantFiled: September 12, 2003Date of Patent: May 16, 2006Assignee: Case Western Reserve UniversityInventors: Joseph W. Boggs, II, Brian J. Wenzel, Kenneth J. Gustafson, Warren M. Grill
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Patent number: 7006870Abstract: An implantable stimulator(s) with at least one infusion outlet and/or at least one electrode, is implanted with the outlet(s) and/or electrode(s) located adjacent to a pudendal nerve(s) and potentially other nerve(s) innervating the reproductive organs, such as the cavernous nerve(s). Stimulation of such nerve(s) is provided via stimulating drugs and/or electrical stimulation as a therapy for erectile dysfunction. The stimulator uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The stimulator provides means of stimulating a nerve(s) when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power. The system is capable of open- and closed-loop operation.Type: GrantFiled: November 12, 2003Date of Patent: February 28, 2006Assignee: Advanced Bionics CorporationInventors: Todd K. Whitehurst, James P. McGivern
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Patent number: 6993390Abstract: An implantable device and method for managing a patient's erectile dysfunction, wherein the device generally comprises: at least one power source member that is adapted to be implanted in the patient's lower abdominal wall; at least one pulse generating member that is adapted to be implanted in the patient's lower abdominal wall; and at least one electrode that is adapted to be implanted at the suprapubic level of the patient's neurovascular bundle of the phallus, is connected to said power source member and pulse generating member, and is adapted to electrically stimulate the neurovascular bundle upon selective activation by the patient.Type: GrantFiled: December 3, 2001Date of Patent: January 31, 2006Inventor: Stephen M. Zappala
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Patent number: 6941171Abstract: A method and system for treatment of incontinence, urgency, frequency, and/or pelvic pain includes implantation of electrodes on a lead or the discharge portion of a catheter adjacent the perineal nerve(s) or tissue(s) to be stimulated. Stimulation pulses, either electrical or drug infusion pulses, are supplied by a stimulator implanted remotely, and through the lead or catheter, which is tunneled subcutaneously between the stimulator and stimulation site. For instance, the system and method reduce or eliminate the incidence of unintentional episodes of bladder emptying by stimulating nerve pathways that diminish involuntary bladder contractions, improve closure of the bladder outlet, and/or improve the long-term health of the urinary system by increasing bladder capacity and period between emptying.Type: GrantFiled: August 16, 2001Date of Patent: September 6, 2005Assignee: Advanced Bionics CorporationInventors: Carla M. Mann, Todd K. Whitehurst, James P. McGivern, Gerald E. Loeb, Frances J. R. Richmond
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Patent number: 6915165Abstract: An intestine dysfunction treatment apparatus comprises an electric stimulation device (56) implanted in a patient, who suffers from intestine dysfunction. The stimulation device comprises electric conductors adapted to directly engage with a muscle that directly or indirectly affects the transportation of the content of the patient's intestines, for example the anal sphincter (58) or a portion of the muscle that contracts the bowels, to electrically stimulate the muscle to increase the tonus thereof. A control device (62) is provided for controlling a source of energy (64), which may or may not be implanted, to release electric energy for use in connection with the power of the stimulation device. The apparatus can be used for treating patients suffering from anal incontinence or constipation.Type: GrantFiled: June 29, 2001Date of Patent: July 5, 2005Assignee: Obtech Medical AGInventor: Peter Forsell
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Patent number: 6907293Abstract: Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.Type: GrantFiled: March 29, 2002Date of Patent: June 14, 2005Assignee: Case Western Reserve UniversityInventors: Warren M. Grill, Kenneth J. Gustafson, Graham H. Creasey
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Methods and systems for direct electrical current stimulation as a therapy for prostatic hypertrophy
Patent number: 6901294Abstract: A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue. The small stimulator provides means of stimulating the prostate with direct electrical current, such as relatively low-level direct current, without the need for external appliances during the stimulation session. The stimulator may be configured to be small enough to be implanted entirely within the prostate. Open- and closed-loop systems are disclosed.Type: GrantFiled: April 26, 2002Date of Patent: May 31, 2005Assignee: Advanced Bionics CorporationInventors: Todd K. Whitehurst, James P. McGivern, Janusz A. Kuzma -
Patent number: 6885895Abstract: Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.Type: GrantFiled: April 9, 2002Date of Patent: April 26, 2005Assignee: Advanced Bionics CorporationInventors: Todd K. Whitehurst, James P. McGivern
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Patent number: 6879858Abstract: A system and method for detecting for and initiating contractions of a uterus of a human patient employs a sensor for sensing electrical activity of the uterus of the patient. Data from the sensed electrical activity is stored in memory. A processor accesses the stored data for analysis. Electrical energy is applied to the uterus to initiate a uterine contraction when the analyzed data fails to satisfy predetermined detection criteria.Type: GrantFiled: November 25, 1998Date of Patent: April 12, 2005Assignee: Reproductive Health Technologies, Inc.Inventor: John M. Adams
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Patent number: 6862479Abstract: One or more implantable system control units (SCU) apply one or more stimulating drugs and/or electrical pulses to a spinal section responsible for innervating the male reproductive organs. The SCU uses a power source/storage device, such as a rechargeable battery. If necessary, periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The SCU provides means of stimulating a tissue(s) with electrical and/or infusion pulses when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the SCU(s) and/or for the transmission of power. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes a sensor, and the sensed condition is used to adjust stimulation parameters.Type: GrantFiled: August 9, 2001Date of Patent: March 1, 2005Assignee: Advanced Bionics CorporationInventors: Todd K. Whitehurst, James P. McGivern
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Publication number: 20040215237Abstract: In general, the invention provides a transurethral ablation device comprising an electrode for delivery of neurostimulation therapy to a patient to prevent or alleviate pain experienced during the course of a transurethral ablation procedure. The device may include a conductive ablation needle that delivers electrical current for ablation of prostate tissue, as well as neurostimulation current to prevent or alleviate pain encountered in response to the ablation current. In this sense, the ablation needle is integrated with a neurostimulation electrode. Alternatively, the device may incorporate a dedicated neurostimulation electrode independently of the ablation needle, either on the needle or on a catheter body that carries the needle.Type: ApplicationFiled: April 25, 2003Publication date: October 28, 2004Applicant: Medtronic, Inc.Inventors: Mark A. Christopherson, John M. Swoyer
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Publication number: 20040193228Abstract: Described are implantable devices and methods for treating various disorders of the pelvic floor by means of electrical stimulation of the pudendal and sacral nerves, or portions thereof, and optional means for delivering drugs in association therewith. Two or more electrical stimulation regimes are applied on a continuous, alternating, intermittent or other basis to the sacral and pudendal nerves, and optionally one or more drugs are infused, injected or otherwise administered, to appropriate portions of a patient's pelvic floor and pudendal nerve and/or sacral nerve, or portions thereof, in an amount and manner effective to treat a number of disorders, including, but not limited to, urinary and/or fecal voiding dysfunctions such as constipation, incontinence disorders such as urge frequency and urinary retention disorders, sexual dysfunctions such as orgasmic and erectile dysfunction, pelvic pain, prostatitis, prostatalgia and prostatodynia.Type: ApplicationFiled: December 23, 2003Publication date: September 30, 2004Inventor: Martin T. Gerber
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Publication number: 20040181261Abstract: Cavernous nerve stimulation is induced by means of a device which creates a time varying magnetic field which, in turn, creates an electric field in a direction parallel to the nerve and at the nerve so as to cause depolarization leading to an action potential and subsequent sensory stimulation and erection.Type: ApplicationFiled: December 16, 2003Publication date: September 16, 2004Inventor: Joseph Manne
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Patent number: RE38654Abstract: An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating.Type: GrantFiled: November 15, 2001Date of Patent: November 23, 2004Assignee: Medtronic, Inc.Inventors: Michael R. S. Hill, Kenneth R. Jonkman