Treating Mental Or Emotional Disorder Patents (Class 607/45)
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Publication number: 20140249445Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.Type: ApplicationFiled: March 4, 2014Publication date: September 4, 2014Applicant: Wake Forest University Health SciencesInventors: Sam Deadwyler, Robert E. Hampson, Mark R. Witcher, Daniel E. Couture, Gautam Popli, Stephen Tatter, Thomas L. Ellis
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Publication number: 20140249598Abstract: A device for brain stimulation that includes n lead having a longitudinal surface; at least one stimulation electrode disposed along the longitudinal surface of the lead; and at least one recording electrode, separate from the at least one stimulation electrode, disposed along she longitudinal surface of the lead.Type: ApplicationFiled: May 9, 2014Publication date: September 4, 2014Applicant: Boston Scientific Neuromodulation CorporationInventor: Paul M. Meadows
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Patent number: 8825153Abstract: A stimulation system can have a first sensor to generate a first reading and a second sensor to generate a second reading. An analysis module of a programmer such as a patient programmer, which programs a stimulation signal to be delivered to a patient, conducts an evaluation of the patient based on the first and second readings. Evaluations may include determinations such as range of motion determinations, posture determinations, physical task-specific brain activity determinations, cognitive task-specific brain activity determinations, and brain activity-specific movement determinations.Type: GrantFiled: August 21, 2012Date of Patent: September 2, 2014Assignee: Intelect Medical, Inc.Inventors: Scott Kokones, Keith Carlton, Alan Greszler
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Patent number: 8825167Abstract: A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.Type: GrantFiled: March 12, 2013Date of Patent: September 2, 2014Assignees: Forschungszentrum Juelich GmbH, ANM Adaptive Neuromodulation GmbH, Universitaet Zu KoelnInventors: Peter A. Tass, Hans-Joachim Freund, Oleksandr Popovych, Birgit Utako Barnikol, Joel Niederhauser, Jean-Christophe Roulet, Urban Schnell
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Patent number: 8825166Abstract: Stimulation treatments for various medical disorders comprise serially varying the stimulation parameters, especially in order to treat multiple symptoms of a disorder. Roving of parameter values can be done in relation to the proportional incidence of the symptoms. Varying the parameters can occur according to algorithms designed in relation to endogenous rhythms of a patient. Especially when using low-frequency stimulation signals the parameter values can be set in order to match or avoid these internal activity patterns and rhythms. These treatment strategies thereby improve the therapeutic efficacy of stimulation or and decrease risk of interference with normal brain, sensory, motor, and cognitive processes. Novel methods are described for choosing, creating and subsequently stimulating with partial signals having unique temporal and spectral profiles which summate to produce desired vector fields, and which may be roved to produce roving vector fields.Type: GrantFiled: January 23, 2007Date of Patent: September 2, 2014Inventor: John Sasha John
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Patent number: 8818515Abstract: Methods and systems for delivering voltage limited neurostimulation to a patient. In one aspect, a method includes initiating a flow of electrical current through a first electrode and a second electrode coupled to the patient and increasing the flow of electrical current toward a target value by increasing a voltage across the first electrode and second electrode. Prior to reaching the target value of electrical current, the method includes preventing the voltage across the first electrode and second electrode from increasing beyond a first predetermined limit; and subsequently, maintaining the voltage across the first electrode and second electrode at or within a predetermined range that does not exceed the first predetermined limit. The amplitude of the electrical current continues to increase toward the target value during at least part of a time when the voltage across the first electrode and the second electrode is maintained within the predetermined range.Type: GrantFiled: January 13, 2012Date of Patent: August 26, 2014Assignee: Research Foundation of the City University of New YorkInventors: Marom Bikson, Christoph Hahn, Shiraz A. Macuff, Preet Minhas, Asif Rahman, Justin Keith Rice
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Publication number: 20140235990Abstract: This disclosure is directed to a machine-based patient-specific seizure classification system. In general, an example system may comprise a non-linear SVM seizure classification system-on-chip (SoC) with multichannel EEG data acquisition and storage for epileptic patients is presented. The SoC may integrate a hardware-efficient log-linear Gaussian Basis Function engine, floating point piecewise linear natural log, and low-noise, high dynamic range readout circuits. In at least one example implementation, the SoC may consume 1.83W/classification while classifying 8 channel results with an average detection rate, average false alarm rate and latency of 95.1%, 0.94% and <2 s, respectively.Type: ApplicationFiled: February 18, 2014Publication date: August 21, 2014Applicant: Masdar Institute of Science and TechnologyInventors: Jerald Yoo, Muhammad Awais Bin Altaf
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Patent number: 8812098Abstract: In some examples, systems, devices, and techniques for determining a particular sleep stage of a patient, determining a seizure state of the patient during the particular sleep stage, and generating a seizure probability metric for the particular sleep stage based on the sleep stage and seizure state are described. In some cases, a patient may be more susceptible to seizure events during particular sleep stages. One or more seizure probability metrics indicative of a patient's susceptibility to seizure events during a particular sleep stage may be useful in creating a patient-specific treatment regimen.Type: GrantFiled: April 16, 2012Date of Patent: August 19, 2014Assignee: Medtronic, Inc.Inventors: Jonathon E. Giftakis, Jianping Wu, Dwight E. Nelson
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Patent number: 8812115Abstract: A method and neurostimulator for providing therapy to a patient is provided. In one technique, electrical background energy is conveyed to a first tissue region of the patient in accordance with stochastic parameter, thereby modulating the excitability of the first tissue region, and electrical stimulation energy is conveyed to the first tissue region when its excitability is modulated. In one example, the stimulation energy may be conveyed to a second tissue region of the patient, thereby therapeutically stimulating the second tissue region. In this case, the excitability of the first tissue region is decreased, thereby reducing any adverse effect that the conveyed stimulation energy has on the first tissue region. As another example, the conveyed stimulation energy stimulates the first tissue region, in which case, the excitability of the first tissue region may be increased, thereby enhancing the stimulation of the first tissue region by the conveyed stimulation energy.Type: GrantFiled: July 10, 2009Date of Patent: August 19, 2014Assignee: Boston Scientific Neuromodulation CorporationInventor: Dongchul Lee
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Patent number: 8812124Abstract: A system for an electrical neurostimulator coupled to a plurality of electrodes. The system comprises a user-controlled input device configured for generating directional control signals. The system further comprises control circuitry configured for sequentially defining a plurality of different ideal multipole configurations that includes two orthogonal ideal tripole configurations relative to the plurality of electrodes in response to the directional control signals, generating a plurality of stimulation parameter sets respectively corresponding to the plurality of different ideal multipole configuration, each stimulation parameter set defining relative amplitude values for the plurality of electrodes that emulate the respective multipole configuration, and instructing the electrical neurostimulator to convey electrical energy to the plurality of electrodes in accordance with the plurality of stimulation parameter sets.Type: GrantFiled: March 14, 2012Date of Patent: August 19, 2014Assignee: Boston Scientific Neuromodulation CorporationInventor: Dongchul Lee
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Publication number: 20140228906Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: April 14, 2014Publication date: August 14, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 8805514Abstract: An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.Type: GrantFiled: March 1, 2013Date of Patent: August 12, 2014Assignee: NeuroPace, Inc.Inventors: Benjamin D. Pless, David R. Fischell, Barbara Gibb, Lisa Guzzo, Adrian R. M. Upton
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Patent number: 8805516Abstract: An integrated system and method for treatment of various diseases, including psychiatric, mental and brain disorders, which preferably combines personalized non-invasive neuronal brain stimulation together with appropriate personalized cognitive training, and which iteratively fine-tunes this treatment by monitoring specific cognitive and brain functions in response to the treatment. A novel brain stimulator device and method, Computerized Magnetic Photo-Electric Stimulator (CCMPES), is described, which integrates electromagnetic stimulation with laser stimulation to generate a magnetic photo-electric stimulation.Type: GrantFiled: June 7, 2013Date of Patent: August 12, 2014Assignee: Neuronix Ltd.Inventor: Jonathan Bentwich
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Patent number: 8805515Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.Type: GrantFiled: April 11, 2013Date of Patent: August 12, 2014Assignee: Intelect Medical, Inc.Inventors: Randall York, Scott Kokones, Keith Carlton, Alan Greszler
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Publication number: 20140222101Abstract: A device determines values for one or more metrics that indicate the quality of a patient's sleep based on sensed physiological parameter values. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. The sleep quality metric values may be used, for example, to evaluate the effectiveness of a therapy delivered to the patient by a medical device. In some embodiments, determined sleep quality metric values are automatically associated with the therapy parameter sets according to which the medical device delivered the therapy when the physiological parameter values were sensed, and used to evaluate the effectiveness of the various therapy parameter sets. The medical device may deliver the therapy to treat a non-respiratory neurological disorder, such as epilepsy, a movement disorder, or a psychological disorder. The therapy may be, for example, deep brain stimulation (DBS) therapy.Type: ApplicationFiled: April 8, 2014Publication date: August 7, 2014Applicant: Medtronic, Inc.Inventors: Keith A. Miesel, Kenneth T. Heruth, Jonathan C. Werder, Steve R. LaPorte, Nina M. Graves
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Patent number: 8798755Abstract: Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.Type: GrantFiled: October 11, 2012Date of Patent: August 5, 2014Assignee: Duke UniversityInventors: Warren M Grill, David T Brocker, Merrill J Birdno
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Patent number: 8798737Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.Type: GrantFiled: September 18, 2007Date of Patent: August 5, 2014Assignee: Sapiens Steering Brain Stimulation B.V.Inventors: Matthias Merz, Youri V. Ponomarev, Remco H. W. Pijnenburg
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Patent number: 8798754Abstract: A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.Type: GrantFiled: March 10, 2008Date of Patent: August 5, 2014Assignee: Venturi Group, LLCInventors: Mark B. Knudson, Adrianus P. Donders, Timothy R. Conrad
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Publication number: 20140214113Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.Type: ApplicationFiled: March 12, 2013Publication date: July 31, 2014Applicant: VALENCIA TECHNOLOGIES CORPORATIONInventors: Jeffrey H. Greiner, David K. L. Peterson, Chuladatta Thenuwara, Stacy O. Greiner
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Publication number: 20140214117Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.Type: ApplicationFiled: September 28, 2012Publication date: July 31, 2014Applicant: VALENCIA TECHNOLOGIES CORPORATIONInventor: VALENCIA TECHNOLOGIES CORPORATION
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Publication number: 20140214118Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.Type: ApplicationFiled: September 28, 2012Publication date: July 31, 2014Applicant: VALENCIA TECHNOLOGIES CORPORATIONInventor: VALENCIA TECHNOLOGIES CORPORATION
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Publication number: 20140213961Abstract: A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATIONInventors: Todd K. Whitehurst, Kristen N. Jaax
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Publication number: 20140214119Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied at at least one of acupoints GB34 and GV20. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.Type: ApplicationFiled: February 12, 2013Publication date: July 31, 2014Applicant: VALENCIA TECHNOLOGIES CORPORATIONInventor: Valencia Technologies Corporation
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Patent number: 8792987Abstract: Deep brain electrodes are remotely sensed and activated by means of a remote active implantable medical device (AIMD). In a preferred form, a pulse generator is implanted in the pectoral region and includes a hermetic seal through which protrudes a conductive leadwire which provides an external antenna for transmission and reception of radio frequency (RF) pulses. One or more deep brain electrode modules are constructed and placed which can transmit and receive RF energy from the pulse generator. An RF telemetry link is established between the implanted pulse generator and the deep brain electrode assemblies. The satellite modules are configured for generating pacing pulses for a variety of disease conditions, including epileptic seizures, Turrets Syndrome, Parkinson's Tremor, and a variety of other neurological or brain disorders.Type: GrantFiled: April 8, 2013Date of Patent: July 29, 2014Assignee: Greatbatch Ltd.Inventors: Robert A. Stevenson, Christine A. Frysz, Barry C. Muffoletto, Robert W. Siegler, Steven W. Winn, Thomas A. Skwara, Dominick J. Frustaci
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Publication number: 20140206945Abstract: A method includes receiving sensor data at a processor from sensors of an external medical device. The sensor data corresponds to at least a first body parameter value for a patient and a second body parameter value for the patient. The method includes determining a first depression-indicative value based on the first body parameter value, a second depression-indicative value based on the second body parameter value, a depression detection value as a function of a first weight applied to the first depression-indicative value and a second weight applied to the second depression-indicative value, and a depression state based at least in part on a comparison of the depression detection value to one or more threshold values.Type: ApplicationFiled: January 22, 2013Publication date: July 24, 2014Applicant: CYBERONICS, INC.Inventor: Wangcai LIAO
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Patent number: 8788064Abstract: Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.Type: GrantFiled: November 12, 2009Date of Patent: July 22, 2014Assignee: Ecole Polytechnique Federale de LausanneInventors: Andre Mercanzini, Philippe Renaud
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Patent number: 8788043Abstract: Methods of locating an optimal site within a brain of a patient for deep brain stimulation include positioning a guiding cannula in a lumen of a main cannula, passing a microelectrode through a lumen of the guiding cannula into the brain, adjusting an insertion depth and a longitudinal angle of the guiding cannula such that the microelectrode locates the optimal site for the deep brain stimulation, and passing a distal end of a macroelectrode or a deep brain stimulation lead through the lumen of the main cannula and into the brain at the optimal site.Type: GrantFiled: April 29, 2013Date of Patent: July 22, 2014Assignee: Boston Scientific Neuromodulation CorporationInventors: Zdzislaw B. Malinowski, Salomo Siilas Murtonen
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Patent number: 8788042Abstract: A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape.Type: GrantFiled: July 29, 2009Date of Patent: July 22, 2014Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)Inventors: Andre Mercanzini, Philippe Renaud
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Publication number: 20140200625Abstract: Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Inventors: Daniel H. KIM, Mir A. IMRAN
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Publication number: 20140200624Abstract: System and method for treating intractable epilepsy are provided. The method includes implanting electrodes in pedunculopontine nucleus and delivering electrical pulses to the pedunculopontine nucleus, thereby inducing the stimulation of cholinergic neurons leading to the release of acetylcholine, thereby enhancing the genesis of rapid eye movement sleep, which reduces the occurrence of epileptic attacks and also chronically suppresses the epileptogenic process.Type: ApplicationFiled: December 17, 2013Publication date: July 17, 2014Inventor: Harinder Jaseja
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Patent number: 8781597Abstract: The present invention provides methods and systems for modulating a patient's neurological disease state. In one embodiment, the system comprises one or more sensors that sense at least one signal that comprise a characteristic that is indicative of a neurological disease state. A signal processing assembly is in communication with the one or more sensors and processes the at least one signal to estimate the neurological disease state and to generate a therapy to the patient that is based at least in part on the estimated neurological disease state. A treatment assembly is in communication with the signal processing assembly and delivers the therapy to a nervous system component of the patient.Type: GrantFiled: May 5, 2010Date of Patent: July 15, 2014Assignee: Cyberonics, Inc.Inventor: Daniel John DiLorenzo
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Publication number: 20140194720Abstract: An elongated device adapted for insertion, including self-insertion, through the body, especially the skull is disclosed. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles. The device may be used to provide electrical, magnetic, and other stimulation therapy to a patient's brain. The lengths of the effectors, sensors, and other components may completely traverse skull thickness (at a diagonal angle) to barely protrude through to the brain's cortex. The components may directly contact the brain's cortex, but from there their signals can be directed to targets deeper within the brain. Effector lengths are directly proportional to their battery size and ability to store charge. Therefore, longer angled electrode effectors not limited by skull thickness permit longer-lasting batteries which expand treatment options.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Inventor: Sherwin Hua
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Publication number: 20140194945Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.Type: ApplicationFiled: March 13, 2014Publication date: July 10, 2014Applicant: Medtronic, Inc.Inventors: Paul H. Stypulkowski, Jonathon E. Giftakis
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Publication number: 20140194944Abstract: An implantable device for the acquisition and monitoring of brain bioelectric signals is described. The implantable device has a plurality of active electrodes configured to detect brain bioelectric signals, the active electrodes being arranged on a grid connected to an electronic module of the implantable device according to a predefined pattern. The active electrodes are connected to a microprocessor of the electronic module through respective paths formed on the grid and connected to at least one analog input unit arranged in the electronic module, the at least one analog input unit being in turn connected to at least one passive electrode and to the microprocessor through a data bus. The at least one analog input unit has an analog-to-digital converter for each active electrode connected thereto. A data acquisition and processing system, which includes the implantable device is also described.Type: ApplicationFiled: April 17, 2012Publication date: July 10, 2014Inventors: Pantaleo Romanelli, Fabio Sebastiano, Antonino Paris, Stefano Marchetti, Paolo Cristiani
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Patent number: 8774923Abstract: A closed loop Deep Brain Stimulation (DBS) system constituted of: a physiological sensor; a multi-electrode DBS lead; an adaptive control system in communication with the physiological sensor; and an implantable pulse generator (IPG) responsive to the adaptive control system, the adaptive control system comprising a learning module operable to learn to find the optimal stimulation parameters, classify and associate patient conditions responsive to the physiological sensor with optimal stimulation parameters in a plurality of patient conditions. The adaptive DBS device control system learns to deliver the optimal stimulation parameters based on Watkins and Dayan Q learning recursive formula, the closed loop adaptive DBS control system thus finds the optimal stimulation parameters online.Type: GrantFiled: March 18, 2010Date of Patent: July 8, 2014Assignee: Sorin CRM SASInventor: Rami Rom
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Patent number: 8768446Abstract: Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.Type: GrantFiled: April 26, 2006Date of Patent: July 1, 2014Assignee: Medtronic, Inc.Inventors: Touby A. Drew, Jonathan C. Werder, Jonathon E. Giftakis, Eric J. Panken
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Patent number: 8768471Abstract: A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.Type: GrantFiled: March 3, 2013Date of Patent: July 1, 2014Assignees: Cyberonics, Inc., Flint Hills Scientific, LLCInventors: John C. Colborn, Mark G. Frei, Ivan Osorio
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Publication number: 20140180358Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Inventors: Jonathon E. Giftakis, Paul H. Stypulkowski, Timothy J. Denison, Scott R. Stanslaski
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Patent number: 8761889Abstract: A method is disclosed for conveying a form of neuromodulation (e.g., electrical, chemical, optical, or thermal) from an external neuromodulation source interiorly of the skull to modulate neural activity. The method involves forming one or more apertures through or partially through the skull to provide an interface for delivering the neuromodulation. A method is disclosed for sensing one or more parameters characteristic of one or more states of the brain through an interface formed with one or more apertures extending all the way or part of the way through the skull. A device is disclosed that is implantable in the skull of a human patient to provide an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be provided in a wide variety of shapes and sizes with or without inner lumens.Type: GrantFiled: September 19, 2008Date of Patent: June 24, 2014Assignee: NeuroPace, Inc.Inventors: Brett Wingeier, Benjamin Pless
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Patent number: 8761884Abstract: A system and method for estimating the longevity of an implantable medical device (IMD). In one embodiment of a method for estimating a life of a power source of an implantable medical device, a first life estimate of the power source is determined based on a first open-loop value corresponding to an open-loop parameter for open-loop therapy delivery, a first closed loop value corresponding to a closed-loop parameter for closed-loop therapy delivery, and prior usage data corresponding to prior therapy delivery. The first life estimate of the power source is displayed. The first life estimate displayed includes a first open-loop portion associated with open-loop therapy delivery and a first closed-loop portion associated with closed-loop therapy delivery.Type: GrantFiled: April 14, 2011Date of Patent: June 24, 2014Assignee: Cyberonics, Inc.Inventor: John C. Colborn
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Patent number: 8761890Abstract: In one example, the disclosure relates to a method comprising receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determining, via one or more processors, a volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site.Type: GrantFiled: January 24, 2013Date of Patent: June 24, 2014Assignee: Medtronic, Inc.Inventors: Rahul Gupta, Steven M. Goetz, Maciej T. Lazarewicz, Gabriela C. Molnar, Dwight E. Nelson, Jianping Wu
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Publication number: 20140172041Abstract: A device for cranial nerve stimulation of an individual is disclosed, having a signal driver unit for producing a current; an intraoral stimulation board having at least one primary electrode, and at least one secondary electrode positioned on the individual for communicating a current through the individual, wherein current can flow between the intraoral stimulation board and the secondary electrode. The device may be used to treat a number of ailments. In one embodiment, the device provides input representing two planes of movement, or is used as a gaming controller. A method of using an electrical stimulation system is also disclosed, comprising the steps of: a) positioning the intraoral stimulation board within the individual's mouth; b) connecting the secondary electrode to the individual; c) operating the signal driver unit for a predetermined time to provide a current flow between the intraoral stimulation board and the secondary electrode.Type: ApplicationFiled: December 13, 2012Publication date: June 19, 2014Applicant: NorDocs Technologies Inc.Inventors: Ovidiu Ioan Draghici, Izmail Batkin, Miodrag Bolic, Ian Stanley Chapman, Alexey Borisenko, Daniel Shapiro, Stanley Shapiro, Brian Dressler
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Patent number: 8755906Abstract: A device for brain stimulation includes a cannula configured and arranged for insertion into a brain of a patient; at least one cannula electrode disposed on the cannula; and an electrode lead for insertion into the cannula, the electrode lead comprising at least one stimulating electrode.Type: GrantFiled: September 10, 2013Date of Patent: June 17, 2014Assignee: Boston Scientific Neruomodulation CorporationInventors: Michael Adam Moffitt, Paul M. Meadows
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Publication number: 20140163627Abstract: The present disclosure provides methods for reducing the clinical presentations of a neurological movement disorder in a subject. Aspects of the methods include measuring cortical local field potentials (LFPs) from the subject's brain, calculating a modulation index related to brain synchronization from the LFPs, and administering deep brain stimulation to the subject if the calculated modulation index is outside of a threshold range. Also provided are devices, systems, and kits that may be used in practicing the subject methods.Type: ApplicationFiled: October 31, 2013Publication date: June 12, 2014Inventors: Philip A. Starr, Coralie de Hemptinne, Jill Ostrem, Nicole Swann
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Publication number: 20140155772Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.Type: ApplicationFiled: February 10, 2014Publication date: June 5, 2014Applicant: Flint Hills Scientific, L.L.C.Inventors: Mark G. Frei, Ivan Osorio
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Publication number: 20140155952Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.Type: ApplicationFiled: June 7, 2013Publication date: June 5, 2014Inventors: Andres M. Lozano, Helen S. Mayberg
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Patent number: 8744582Abstract: The disclosure describes an implantable neurostimulator device for delivery of neurostimulation to treat head, neck, or facial pain or tension, including pain or tension caused by occipital neuralgia. The device may be a neurostimulation device having a miniaturized housing with a low profile that permits subcutaneous implantation at a stimulation site directly adjacent a neuralgic region at the back of the neck of a patient. For example, the device may be subcutaneously implanted at the back of the neck of a patient to relieve symptoms of occipital neuralgia.Type: GrantFiled: November 3, 2009Date of Patent: June 3, 2014Assignee: Medtronic, Inc.Inventors: Carl D. Wahlstrand, Robert M. Skime
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Publication number: 20140148870Abstract: In certain variations, systems and/or methods for electromagnetic induction therapy are provided. One or more ergonomic or body contoured applicators may be included. The applicators include one or more conductive coils configured to generate an electromagnetic or magnetic field focused on a target nerve, muscle or other body tissues positioned in proximity to the coil. One or more sensors may be utilized to detect stimulation and to provide feedback about the efficacy of the applied electromagnetic induction therapy. A controller may be adjustable to vary a current through a coil to adjust the magnetic field focused upon the target nerve, muscle or other body tissues based on the feedback provide by a sensor or by a patient. In certain systems or methods, pulsed magnetic fields may be intermittently applied to a target nerve, muscle or tissue without causing habituation.Type: ApplicationFiled: November 20, 2013Publication date: May 29, 2014Applicant: EMKINETICS, INC.Inventor: Daniel R. BURNETT
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Publication number: 20140148872Abstract: Described herein are devices, systems, and methods for transdermal electrical stimulation. Devices described herein can include self-contained, lightweight, and wearable components. The devices include a primary unit including a first transdermal electrode and a secondary unit including a second transdermal electrode. The device can be capable of wireless communication. The primary unit and secondary unit are placed at two locations on the skin of a user, for example on the head or neck of a user. The first and second transdermal electrodes are electrically connected. Electrical stimulation is driven between the two electrodes. The electrical stimulation induces a cognitive effect in a user of the device.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Inventors: Isy GOLDWASSER, William J. TYLER, Alexander OPITZ, Tomokazu SATO, Jonathan CHARLESWORTH, Sumon K. PAL, Philip LAMB, Christopher VOSS, Steven COOK, Remi DEMERS, Raymond L. GRADWOHL, Daniel Z. WETMORE
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Patent number: 8738136Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.Type: GrantFiled: August 13, 2007Date of Patent: May 27, 2014Assignee: Medtronic, Inc.Inventors: Mark G. Frei, Ivan Osorio, Nina M. Graves, Scott F. Schaffner, Mark T. Rise, Jonathon E. Giftakis, David L. Carlson