Treating Mental Or Emotional Disorder Patents (Class 607/45)
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Patent number: 9192670Abstract: A method of treating Alzheimer's disease (AD) is disclosed. The method comprises electrically stimulating a nerve pathway in a brain region of a subject with at least two high frequency spike bursts of electrical currents, the bursts comprising between 2-20 spikes, wherein a frequency of the spikes in the bursts is between 5-200 msec.Type: GrantFiled: May 3, 2012Date of Patent: November 24, 2015Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Inna Slutsky, Iftach Dolev
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Patent number: 9186505Abstract: Transcranial electrostimulation is used to treat a number of ailments including depression and pain management amongst others. However, long term transcranial electrostimulation can lead to the hyperpolarization in the membrane of the post synaptic neurons reducing or eliminating the positive effects. Thus, by using a “white noise” (clock) generator and taking advantage of polarity inversions empirical evidence has shown this to reduce or prevent the negative effects associated with long term use of current transcranial devices and methods.Type: GrantFiled: November 20, 2014Date of Patent: November 17, 2015Assignee: NOVO HB, LLCInventor: Yakov Katsnelson
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Patent number: 9186508Abstract: An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.Type: GrantFiled: October 21, 2013Date of Patent: November 17, 2015Assignee: NeuroPace, Inc.Inventors: Thomas K. Tcheng, Robert E. Fischell, Benjamin D. Pless
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Patent number: 9186507Abstract: The present invention is a method of improving the persistence of electrical neural stimulation, and specifically a method of improving the persistence of an image supplied to a retina, or visual cortex, through a visual prosthesis. A continuously stimulated retina, or other neural tissue, will desensitize after a time period in the range of 20 to 150 seconds. However, an interruption of the stimulation on the order of a few milliseconds will restore the retinal sensitivity without the user perceiving the interruption, or with the user barely perceiving the interruption.Type: GrantFiled: August 17, 2006Date of Patent: November 17, 2015Assignee: Second Sight Medical Products, Inc.Inventors: Arup Roy, Robert J. Greenberg, Mark S. Humayun, Kelly H. McClure
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Patent number: 9173609Abstract: A brain condition can be tracked based on identification of co-activation of two antagonistic networks of a patient's brain. Various embodiments concerns methods and devices for sensing one or more signals indicative of brain activity, detecting one or more episodes of default mode network activation based on the one or more signals, detecting one or more episodes of salience network activation based on the one or more signals, and identifying one or more episodes of temporal co-activation of the default mode network and the salience network based on the detected one or more episodes of default mode network activation and the one or more episodes of salience network activation. The brain condition can be tracked and treated based on the identification of the one or more episodes of co-activation.Type: GrantFiled: April 13, 2012Date of Patent: November 3, 2015Assignee: Medtronic, Inc.Inventor: Dwight E. Nelson
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Patent number: 9168372Abstract: A method and system are provided for removing, from an implant chamber of a heart, a leadless implantable medical device (LIMD) having a distal end and a proximal end. The distal end is configured to be actively secured to tissue in the implant chamber of the heart. The proximal end is configured to be coupled to a distal end of an indwelling retrieval mechanism (IRM). The IRM extends from the heart along a vessel, the IRM having a proximal end configured to be anchored at a temporary anchor site. The method comprises detaching the IRM from the anchor site, loading a retrieval tool over the proximal end of the IRM and along the body of the IRM. The retrieval tool has a lumen therein that receives the IRM as the retrieval tool re-enters the vessel, thereby allowing the retrieval tool to engage the LIMD.Type: GrantFiled: March 7, 2013Date of Patent: October 27, 2015Assignee: PACESETTER, INC.Inventor: Eric S. Fain
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Patent number: 9162049Abstract: A tissue stimulating device has an elongate member, a proximal annular stimulating region and a distal annular stimulating region. Each of the annular stimulating regions circumscribe the elongate member, and each has a plurality of independently energizable electrodes that deliver current into tissue. Adjacent electrodes in the annular stimulating regions are separated from one another by an insulating member. The annular stimulating regions are axially separated from one another by a gap. An internal electrical connector electrically couples a first electrode in the proximal annular stimulating region with a first electrode in the distal annular stimulating region. The first internal electrical connector is disposed within the elongate member, and extends across the gap between annular stimulating regions. A recording electrode is disposed in the gap and is adapted to record local tissue potentials from the tissue.Type: GrantFiled: October 8, 2013Date of Patent: October 20, 2015Assignee: Boston Scientific Neuromodulation CorporationInventor: Purvis Bedenbaugh
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Patent number: 9162052Abstract: Methods of treating language, behavioral and social disorders are described, including methods of treating language disorders associated with electrographic abnormalities in the primary or associative language cortex of persons with autism spectrum disorders, pervasive developmental delay or acquired epileptic aphasia. A language, behavioral and social disorder may be treated by detecting epileptiform activity or an electrographic seizure for a subject's brain and applying neurostimulation to a language cortical region of the subject's brain (e.g., a primary or associative language cortical region). Detection of epileptiform activity or an electrographic seizure and stimulation of language cortex may be performed by a sensing and/or stimulation electrode that is inserted into a subject's brain and connected to one or more neurostimulation devices for monitoring and/or stimulating the language cortex.Type: GrantFiled: September 7, 2009Date of Patent: October 20, 2015Assignee: NeuroPace, Inc.Inventor: Martha J. Morrell
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Patent number: 9162051Abstract: Methods of treating language, behavioral and social disorders are described, including methods of treating language disorders associated with electrographic abnormalities in the primary or associative language cortex of persons with autism spectrum disorders, pervasive developmental delay or acquired epileptic aphasia. A language, behavioral and social disorder may be treated by detecting epileptiform activity or an electrographic seizure for a subject's brain and applying neurostimulation to a language cortical region of the subject's brain (e.g., a primary or associative language cortical region). Detection of epileptiform activity or an electrographic seizure and stimulation of language cortex may be performed by a sensing and/or stimulation electrode that is inserted into a subject's brain and connected to one or more neurostimulation devices for monitoring and/or stimulating the language cortex.Type: GrantFiled: September 21, 2006Date of Patent: October 20, 2015Assignee: NeuroPace, Inc.Inventor: Martha J. Morrell
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Patent number: 9165472Abstract: A method and system provides for electrophysiological data analysis in a networked processing environment. The method and system includes receiving, via a networked connection, electrophysiological data of a patient and electronically performing, via at least one network processing device, a data analysis on the electrophysiological data. The method and system includes generating at least one report based on the data analysis, wherein the at least one report includes determination of one or more intervention options for the patient and therein transmitting the report to a recipient device across the network connection for utilization with the patient. The results of the report direct the user to apply from within the same system non-invasive brain stimulation, neurofeedback, and biofeedback modalities.Type: GrantFiled: March 17, 2014Date of Patent: October 20, 2015Assignee: EVOKE NEUROSCIENCEInventors: David W Hagedorn, James W. G. Thompson
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Patent number: 9155892Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fiber population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fiber population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronized or desynchronized to give directional control over responses evoked.Type: GrantFiled: May 11, 2012Date of Patent: October 13, 2015Assignee: Saluda Medical Pty LimitedInventors: John Louis Parker, James Hamilton Laird
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Patent number: 9149643Abstract: A communications bridge device communicates between a consumer electronics device, such as a smart telephone, and an implantable medical device. The bridge forwards instructions and data between the consumer electronics device and the implantable medical device. The bridge contains a first transceiver that operates according to a communication protocol operating in the consumer electronics device (such as Bluetooth®), and second transceiver that operates according to a communications technique operating in the implantable medical device (e.g., Frequency Shift Keying). A software application is installed on the consumer electronics device, which provides a user interface for controlling and reading the implantable medical device. The software application is downloadable using standard cellular means. The bridge is preferably small, and easily and discreetly carried by the implantable medical device patient.Type: GrantFiled: March 16, 2015Date of Patent: October 6, 2015Assignee: Boston Scientific Neuromodualtion CorporationInventors: Samuel Tahmasian, Daniel Aghassian, Douglas Michael Ackermann, Joonho Hyun, Dennis Ralph Zottola
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Patent number: 9144682Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.Type: GrantFiled: September 3, 2014Date of Patent: September 29, 2015Assignee: The University of North Carolina GreensboroInventors: Joseph M. Starobin, Vivek Varadarajan
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Patent number: 9138580Abstract: Described herein are methods and systems for improving or adapting a breathing pattern of a patient with disordered breathing toward a more helpful state, as well as systems and devices for adapting breathing. These methods and systems may be used for improving sleep in patients with sleep disordered breathing and a system by which to implement devices for performing these methods.Type: GrantFiled: April 23, 2013Date of Patent: September 22, 2015Assignee: Synapse Biomedical, Inc.Inventors: Anthony R. Ignagni, Raymond P. Onders
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Patent number: 9131887Abstract: Disclosed is an system for measuring mood states, which calculate and views high-accurate mood indices from brain activation signals obtained by a non-invasive biospectrometric technology, taking account into differences among individuals, for example cognitive capacity using methods supporting the measurement of mood states of individuals. The system of the present invention stores a plurality of different mood index calculation formulae, selects one of the plurality of mood index calculation formulae based on a personal trait, for example the working memory task performance or working memory capacity of a subject, and substitutes the brain activation data of the subject for the selected calculation formula to calculate and view mood indices.Type: GrantFiled: January 11, 2013Date of Patent: September 15, 2015Assignee: Hitachi, Ltd.Inventors: Hiroki Sato, Masashi Kiguchi
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Patent number: 9126042Abstract: An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.Type: GrantFiled: September 12, 2014Date of Patent: September 8, 2015Assignee: NeuroPace, Inc.Inventors: Thomas K. Tcheng, Robert E. Fischell, Benjamin D. Pless
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Patent number: 9119543Abstract: A system (10) and a method for deep brain stimulation are provided. The system (10) comprises a probe (11) and a processor (14). The probe (11) comprises an array of sensing electrodes (12) for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes (12) for applying stimulation amplitudes to corresponding brain regions. The processor (14) is operably coupled to the sensing electrodes (12) and the stimulation electrodes (12) and is arranged for performing the method according to the invention.Type: GrantFiled: July 23, 2010Date of Patent: September 1, 2015Assignee: Medtronic Bakken Research Center B.V.Inventor: Hubert Cécile François Martens
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Patent number: 9108057Abstract: The present invention is directed to a method for treating a gastrointestinal condition by transvascular neuromodulation of a target site of the autonomic nervous system and preferably a target site in communication with a sympathetic nerve chain. A method for treating a gastrointestinal condition via transvascular neuromodulation incorporating a closed-loop feedback system is also provided.Type: GrantFiled: October 12, 2010Date of Patent: August 18, 2015Assignee: The Cleveland Clinic FoundationInventors: Ali Rezai, Mehdi Ansarinia
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Patent number: 9101770Abstract: System and methods for programming and delivering electrical stimulation to treat hypertension are discussed. In various embodiments, an ambulatory stimulator system, such as an implantable medical device, can receive a power-saving command and deliver the electrical stimulation to a target site in a patient according to one or more simulation parameters including a therapy on-off pattern. In some embodiments, stimulation with therapy on-off pattern can reduce the power consumption while maintaining the anti-hypertension therapy efficacy. In some embodiments, the ambulatory stimulator system can include one or more of a physiologic response detector, a patient status detector, or a battery longevity detector. The power-saving command can be generated using one or more of the detected physiologic signal, the patient status, or the information about the battery longevity.Type: GrantFiled: February 20, 2014Date of Patent: August 11, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Shantha Arcot-Krishnamurthy, Eric A. Mokelke, David J. Ternes
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Patent number: 9104974Abstract: An apparatus and a method for transmitting and receiving a spike event in a neuromorphic chip. A transmission apparatus of the neuromorphic chip outputs addresses sequentially and repeatedly to an address bus, and when a spike generated by a neuron is detected by the transmission apparatus, outputs a strobe at a first time when one of the addresses being output sequentially and repeatedly becomes identical to an address of the neuron that generated the spike. A receiving apparatus of the neuromorphic chip inputs an address through the address bus at a strobe detection time when the strobe is detected by the receiving apparatus.Type: GrantFiled: July 27, 2012Date of Patent: August 11, 2015Assignees: Samsung Electronics Co., Ltd., POSTECH Academy-Industry FoundationInventors: Jae Yoon Sim, Jun Haeng Lee, Hyun Surk Ryu, Keun Joo Park, Chang Woo Shin
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Patent number: 9095303Abstract: A method, comprising detecting an epileptic event in a neural network, wherein the event occurs in a first node; identifying a second node; and applying a therapy to the second node or any connection. A method, comprising determining a first body index indicative of epileptic activity; monitoring a second body index; detecting an indication of activity spread, based upon at least the second body index; and taking a responsive action, such as delivering therapy, modifying therapy, logging the indication, or warning. A method, comprising detecting an epileptic event in a first node of a neural network; applying a first therapy to a first neural structure for treating the event; and applying a second therapy to a second neural structure of the patient based on an event spread proclivity to a third neural structure. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform a method.Type: GrantFiled: April 17, 2012Date of Patent: August 4, 2015Assignee: FLINT HILLS SCIENTIFIC, LLCInventor: Ivan Osorio
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Patent number: 9095713Abstract: Methods of treating autism include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulus is configured to decrease neural activity within at least a portion of the brain to treat autism. Systems for treating autism include a stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The stimulus is configured to decrease neural activity within at least a portion of the brain to treat autism.Type: GrantFiled: June 30, 2006Date of Patent: August 4, 2015Inventors: Allison M. Foster, Todd K. Whitehurst, Rafael Carbunaru, Derrick Sung
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Patent number: 9089703Abstract: Disclosed is a method of enhancing exposure therapy comprising providing an exposure therapy to a patient and stimulating the patient's vagus nerve at the same time as the exposure therapy. Also disclosed is a post-traumatic stress disorder therapy method comprising providing an exposure event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is a phobia disorder therapy method comprising providing an extinction event to a patient and stimulating the patient's vagus nerve during the extinction event. Also disclosed is an obsessive compulsive disorder therapy method comprising providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. Also disclosed is an addiction disorder therapy method comprising providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event.Type: GrantFiled: April 27, 2011Date of Patent: July 28, 2015Assignees: MICROTRANSPONDER, INC., THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Christa McIntyre Rodriguez, Navzer Dara Engineer
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Patent number: 9089707Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.Type: GrantFiled: June 15, 2009Date of Patent: July 28, 2015Assignee: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Michael P Kilgard, Lawrence James Cauller, Navzer Engineer, Christa McIntyre, Will Rosellini
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Patent number: 9079029Abstract: A patient treatment unit for analyzing and treating abnormality of human or animal tissues, includes a display; a pulse generator circuit that outputs a sequence of electrical pulses at a pulse frequency, the electrical pulses having a pulse width, the pulse generator controlling the pulse frequency and the pulse width of the electrical pulses; a pair of probes for contacting a body of a patient and electrically coupled to the pulse generator; and a voltage and current sensing circuit that senses a voltage or a current via the probes when contacting the body of the patient.Type: GrantFiled: July 23, 2014Date of Patent: July 14, 2015Assignee: NewLife Sciences, LLCInventor: Ronald J. Weinstock
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Patent number: 9072906Abstract: A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape.Type: GrantFiled: June 26, 2014Date of Patent: July 7, 2015Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Andre Mercanzini, Philippe Renaud
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Patent number: 9072832Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.Type: GrantFiled: April 25, 2014Date of Patent: July 7, 2015Assignee: Medtronic, Inc.Inventors: Mark G. Frei, Ivan Osorio, Nina M. Graves, Scott F. Schaffner, Mark T. Rise, Jonathon E. Giftakis, David L. Carlson
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Patent number: 9072870Abstract: Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.Type: GrantFiled: September 25, 2008Date of Patent: July 7, 2015Assignee: Medtronic, Inc.Inventors: Jianping Wu, Gregory F. Molnar, Gabriela C. Miyazawa, Timothy J. Denison
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Patent number: 9056195Abstract: A method includes determining sleep cycle information related to a sleep cycle of a patient based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the sleep cycle information.Type: GrantFiled: March 15, 2013Date of Patent: June 16, 2015Assignee: CYBERONICS, INC.Inventor: Shivkumar Sabesan
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Patent number: 9050472Abstract: A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.Type: GrantFiled: May 13, 2013Date of Patent: June 9, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Shantha Arcot-Krishnamurthy, David J. Ternes, Jason Hamann, Juan Gabriel Hincapie Ordonez, Stephen B. Ruble
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Patent number: 9044613Abstract: A transcutaneous waveform generator capable of producing a therapeutic shaped wave that may be administered to the user without perception of electrical stimulation.Type: GrantFiled: November 6, 2013Date of Patent: June 2, 2015Inventors: Douglas C. Harding, Alma Ray Ivie, Richard J. Ivie
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Publication number: 20150148864Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.Type: ApplicationFiled: January 29, 2015Publication date: May 28, 2015Inventors: David K. L. Peterson, Stacy Greiner Chambliss
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Publication number: 20150148863Abstract: A brain stimulating system is provided. In some embodiments, the system includes a first electrode configured to supply a minute electric current to stimulate a brain, and a second electrode configured to detect at least one brain signal received from a brain, wherein the second electrode includes a blocking filter configured to block the minute electric current.Type: ApplicationFiled: December 12, 2013Publication date: May 28, 2015Applicant: YBRAIN INC.Inventors: Kyongsik Yun, Yongwook Chae, Kiwon Lee
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Patent number: 9042989Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.Type: GrantFiled: January 22, 2014Date of Patent: May 26, 2015Assignee: Medtronic, Inc.Inventors: David L. Carlson, Randy M. Jensen, Timothy J. Denison, Jianping Wu, Gabriela C. Molnar, Scott R. Stanslaski, William J. Marks, Jr.
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Patent number: 9042990Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.Type: GrantFiled: January 22, 2014Date of Patent: May 26, 2015Assignee: Medtronic, Inc.Inventors: David L. Carlson, Randy M. Jensen, Timothy J. Denison, Jianping Wu, Gabriela C. Molnar, Scott R. Stanslaski, William J. Marks, Jr.
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Patent number: 9042988Abstract: The present invention provides a closed-loop system for treating neurological disorders, such as epilepsy. In one embodiment the system comprises an input assembly that is adapted to receive one or more signals from a patient that are indicative of a patient's neurological state. The input assembly processes the one or more signals to generate one or more control input signals. An output assembly receives the one or more control input signals from the input assembly and generate a neuromodulation signal that is a function of the patient's neurological state. An electrode array is configured to deliver the neuromodulation signal to a patient's peripheral nerve, such as the vagus nerve.Type: GrantFiled: November 17, 2005Date of Patent: May 26, 2015Assignee: CYBERONICS, INC.Inventor: Daniel John DiLorenzo
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Patent number: 9033861Abstract: A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.Type: GrantFiled: August 27, 2009Date of Patent: May 19, 2015Assignee: NeuroPace, Inc.Inventors: David R. Fischell, Adrian R.M. Upton
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Patent number: 9037256Abstract: A system and method for selecting optimal stimulation parameter settings for a therapeutic neural stimulation for a current patient may include obtaining, by at least one processor, electrical parameter maps and corresponding score values of a patient population, and processing, by the at least one processor, the parameter maps and the score values to evaluate, based on a set of score criteria, parameter maps associated with potential stimulation parameter settings.Type: GrantFiled: August 31, 2012Date of Patent: May 19, 2015Assignee: Boston Scientific Neuromodulation CorporationInventor: Hemant Sharad Bokil
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Patent number: 9037268Abstract: The portable, wearable, proximal Alzheimer's disease treatment invention is based upon creating an RF field of particular frequencies and intensities that are applied to the patient's head. To accomplish the aforementioned disease treatment functionality, a system was invented comprising a network of antennas connected to an RF generator via a feedline connector. The invention also provides methods for using measurements to monitor and manage the effectiveness of an ongoing disease treatment regimen, and databases which contain information about measurements, variables, and their relationships to clinical outcome.Type: GrantFiled: September 11, 2013Date of Patent: May 19, 2015Inventor: Eric A. Knight
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Patent number: 9031656Abstract: Methods for treating seizures caused by brain stimulation include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to treat a medical condition, applying at least one stimulus with the stimulator to a stimulation site within the brain of a patient in accordance with the one or more stimulation parameters, and monitoring the patient for a seizure caused by the at least one stimulus.Type: GrantFiled: November 6, 2013Date of Patent: May 12, 2015Assignee: Boston Scientific Neuromodulation CorporationInventors: Todd K. Whitehurst, Rafael Carbunaru, Kristen N. Jaax, Andrew DiGiore, Brett Schleicher, Greg Baldwin
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Patent number: 9031655Abstract: The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.Type: GrantFiled: October 7, 2013Date of Patent: May 12, 2015Assignee: Flint Hills Scientific, LLCInventors: Ivan Osorio, Mark G. Frei
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Patent number: 9031657Abstract: An implantable device for the acquisition and monitoring of brain bioelectric signals is described. The implantable device has a plurality of active electrodes configured to detect brain bioelectric signals, the active electrodes being arranged on a grid connected to an electronic module of the implantable device according to a predefined pattern. The active electrodes are connected to a microprocessor of the electronic module through respective paths formed on the grid and connected to at least one analog input unit arranged in the electronic module, the at least one analog input unit being in turn connected to at least one passive electrode and to the microprocessor through a data bus. The at least one analog input unit has an analog-to-digital converter for each active electrode connected thereto. A data acquisition and processing system, which includes the implantable device is also described.Type: GrantFiled: April 17, 2012Date of Patent: May 12, 2015Assignee: AB Medica S.p.A.Inventors: Paolo Cristiani, Antonino Paris, Stefano Marchetti, Panlaleo Romanelli, Fabio Sebastiano
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Publication number: 20150126802Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.Type: ApplicationFiled: February 18, 2013Publication date: May 7, 2015Inventors: Hubert H. Lim, Craig D. Markovitz, Sarah J. Offutt
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Patent number: 9026218Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.Type: GrantFiled: June 7, 2013Date of Patent: May 5, 2015Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andres M. Lozano, Helen S. Mayberg
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Patent number: 9026216Abstract: The invention proposes a system and a method for controlling the process of prescription and administration of direct current stimulation treatments in humans. In the proposed system, the stimulation parameters are all set by a specialist whose credentials are verified through a specific control device different from the device that delivers electrical stimulation. The stimulating device can deliver the stimulation only if the credentials of the specialized subject making the prescription are verified and if the prescription is made according to safety criteria. The system is composed by at least one device for the administration of electrical current connected to two electrodes applied over the skin and by a control device. The control device is connected to one or more devices for the administration of the direct current through a communication channel. The specialist gives his own credentials and is authorized at making the prescription and, accordingly, programming the stimulating device.Type: GrantFiled: June 10, 2009Date of Patent: May 5, 2015Inventors: Lorenzo Rossi, Sara Renata Francesca Marceglia, Simona Mrakic-Sposta, Laura Bertolasi
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Patent number: 9026217Abstract: A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.Type: GrantFiled: August 23, 2011Date of Patent: May 5, 2015Assignee: Intelect Medical, Inc.Inventors: Scott Kokones, David Arthur Blum, Keith Carlton
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Patent number: 9020604Abstract: A neurostimulation device is provided comprising an input, a neurostimulation probe, a stimulation unit and a distribution calculation module. At the input stimulation data is received comprising information relating to a stimulation preferability and an orientation of at least one fiber bundle. The neurostimulation probe comprises an array of stimulation electrodes which are coupled to the stimulation unit. The stimulation unit, in accordance with a specified current distribution, provides currents to the respective stimulation electrodes for generating an electric field gradient. The distribution calculation module is coupled to the input and the stimulation unit for based on the stimulation data determining a preferred position and orientation for the electric field gradient, and based on the preferred position and orientation for the electric field gradient, calculating the specified current distribution.Type: GrantFiled: October 31, 2011Date of Patent: April 28, 2015Assignee: Sapiens Steering Brain Stimulation B.V.Inventor: Hubert Cecile Francois Martens
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Patent number: 9020607Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.Type: GrantFiled: June 26, 2014Date of Patent: April 28, 2015Assignee: Sapiens Steering Brain Stimulation B.V.Inventors: Matthias Merz, Youri V. Ponomarev, Remco H.W. Pijnenburg
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Patent number: 9020612Abstract: In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when postactivity stimulation is not applied.Type: GrantFiled: July 25, 2014Date of Patent: April 28, 2015Inventors: Yuri P. Danilov, Mitchell E. Tyler, Kurt A. Kaczmarek
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Patent number: 9020606Abstract: Disclosed is a device for anchoring a brain lead that includes an anchoring ring with a circular base and a flange joining together where the inner walls form an aperture define a passage of a lead. Outer walls engage with a burr hole to secure the ring to the cranium, and a septum is contained within the aperture of the anchoring ring. Because the septum is already placed in the aperture when the trocar is removed from the brain, the body of the brain lead is immediately clamped by the elastic material of the septum while the tip of trocar is removed from the slit of septum. Friction between the lead body and the elastic material prohibits any movement of the lead caused by handling.Type: GrantFiled: December 12, 2011Date of Patent: April 28, 2015Assignee: Sceneray Co., Ltd.Inventor: Weizhong Yin