Electrical Treatment Of Pain Patents (Class 607/46)
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Patent number: 12642972Abstract: Devices, systems, or methods include generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue; and generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second tram of electrical stimulation pulses. At least the first target tissue is associated with a spinal cord of a patient, and the second target tissue is associated with at least one of a peripheral nerve or a nerve root of the patient.Type: GrantFiled: February 24, 2022Date of Patent: June 2, 2026Assignee: Medtronic, Inc.Inventors: Brooke G. Kelley, Juan G. Hincapie, Andrew J. Cleland
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Patent number: 12642966Abstract: Systems, devices, and methods are disclosed for computer-assisted goal setting and tracking with respect to neuromodulation device treatment. A digital health system includes a user-interface device to receive a user input about a personalized objective of neuromodulation treatment or an intended manner of using the neuromodulation device by the patient. The user input can be in forms of text, voice, or other unstructured or unclassified data formats. A controller circuit can process the user input using analytical methods including natural language processing to generate a personalized treatment and device usage goal, and track the progress toward the personalized treatment and device usage goal using patient state information. The tracked progress may be presented to the patient, or be used to initiate or adjust a neuromodulation therapy.Type: GrantFiled: October 16, 2023Date of Patent: June 2, 2026Assignee: Boston Scientific Neuromodulation CorporationInventors: Kyle Harish Srivastava, Amarpreet Singh Bains, Benjamin Phillip Hahn
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Patent number: 12623068Abstract: Systems and methods for providing curated neurostimulation are disclosed such that users are enabled to provide improved therapy in a home environment. Stimulation protocols can be assessed to provide improved targeted stimulation of a nerve and less unwanted side effects. Sets of stimulation montages and associated weights are defined and are selected or adjusted in pre-defined using pre-defined operations that simplify adjustment of characteristics of the stimulation field such as the geometry and location of the provided stimulation. Stimulation matrix pads are arranged and activated to provide advantages. Strategies for adjusting the intensity of the stimulation field incorporate weighting values in non-primary channels and are disclosed. Curated neurostimulation can also include providing defined schedules for events and activities related to the therapy such as providing schedules for stimulation treatment, surveying a user, providing education and remote user support.Type: GrantFiled: January 19, 2023Date of Patent: May 12, 2026Assignee: EBT Medical Inc.Inventors: Michael Sasha John, Mike Labbe, Keith R. Carlton, Paul B. Yoo, Suranjan Roychowdhury, Tamara Baynham, Ken W. Mariash, David Lubensky, John Lai, Brian Hoffer, Rachel Lichte, Jon Lawson
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Patent number: 12622748Abstract: There are many devices that are used to deliver electromagnetic energy to biological tissues. However, physical properties of current techniques limit the strength and efficacy of the applied field. This invention introduces a new apparatus for the application of evanescent waves into biological tissue. The apparatus is planar, conformal, and electrically insulated and is comprised of two or more conductive regions spatially separated by a non-conductive gap insulated by low-dielectric constant, non-conductive material. The apparatus is powered by one or more RF voltage sources that can be applied to individual or several conductive regions to create voltage differentials that generate evanescent waves. The apparatus can be used for treating cancer tumors, deep brain stimulation, and other therapeutic purposes.Type: GrantFiled: March 6, 2023Date of Patent: May 12, 2026Assignee: EVANESC THERAPEUTICS, INC.Inventors: Timothy J. Brockett, Mehran Matloubian, Gregg A. Hollingsworth
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Patent number: 12623070Abstract: In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation.Type: GrantFiled: May 20, 2020Date of Patent: May 12, 2026Assignees: The Regents of the University of California, Scoula Internazionale Superiore di Studi Avanzati—Sissa, University of Southern CaliforniaInventors: Parag Gad, Victor Reggie Edgerton, Giuliano Taccola, Evgeniy I. Kreydin
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Patent number: 12613624Abstract: A planning and/or control system for providing stimulation is disclosed. The system can include a graphical presentation module configured and arranged for providing graphical information about an electrode array comprising multiple electrodes and/or an implantation side for the electrode array comprising at least one target area, a selection module configured and arranged for determining a stimulation zone and/or a stimulation direction on the electrode array comprising at least one electrode and/or for individually selecting at least one electrode and/or for selecting at least one target area, and a calculation module configured and arranged for determining a contribution of currents provided by electrodes of the stimulation zone and/or stimulation direction on the electrode array and/or the at least one electrode selected and/or to the at least one target area selected.Type: GrantFiled: November 19, 2020Date of Patent: April 28, 2026Assignee: Onward Medical N.V.Inventors: Robin Brouns, Jurriaan Bakker, Miroslav Caban
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Patent number: 12611139Abstract: Described herein are apparatuses and methods for classifying a patient as being asleep or awake. Such an apparatus can include an accelerometer and a processor. The accelerometer, alone or in combination with the processor, is used to determine an activity level of the patient and a posture of the patient. The processor is configured to classify the patient as being asleep in response to both (i) the posture of the patient being recumbent or reclined for at least a sleep latency duration, and (ii) the activity level of the patient not exceeding an activity threshold for at least the sleep latency duration; and classify the patient as being awake in response to at least one of (iii) the posture of the patient being upright for at least an awake latency duration, or (iv) the activity level of the patient exceeding the activity threshold for at least the awake latency duration.Type: GrantFiled: November 14, 2023Date of Patent: April 28, 2026Assignee: Pacesetter, Inc.Inventors: Jong Gill, Prakrit Shrestha, Kyungmoo Ryu
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Patent number: 12605547Abstract: A method of providing electrical stimulation therapy to a patient according to one embodiment includes generating an un-tuned electrical noise signal by at least one noise generator, partitioning the un-tuned electrical noise signal into a plurality of discrete frequency bands having corresponding bandwidths, delivering the un-tuned electrical noise signal through one or more electrodes to the patient to target the patient's central or peripheral nervous system, adjusting, for each of a plurality of selected frequency bands, an amplitude of the voltage or current of the un-tuned electrical noise signal within a corresponding frequency band to generate an adjusted electrical stimulation signal based on feedback received from the patient, wherein the adjusted electrical stimulation signal includes a plurality of local maxima and a plurality of local minima, and delivering the adjusted electrical stimulation signal through the electrodes to provide electrical stimulation therapy to the patient.Type: GrantFiled: March 11, 2024Date of Patent: April 21, 2026Assignee: Soin Neuroscience, LLCInventors: Eric A. Schepis, Amol Soin
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Patent number: 12599432Abstract: Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) by delivering specialized pulsed electric field (PEF) energy to target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing thermal ablation). Consequently, when extracellular matrices present, the extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to target tissue throughout the body, particularly in locations previously considered inaccessible to percutaneous approaches.Type: GrantFiled: October 15, 2021Date of Patent: April 14, 2026Assignee: Galvanize Therapeutics, Inc.Inventors: Seth S. Gleiman, Nicholas S. Mercer, Timothy J. O'Brien, Jonathan R. Waldstreicher, Kevin J. Taylor, Luis L. Mangual Arbelo, Robert E. Neal, William Sanford Krimsky, Quim Castellvi
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Patent number: 12594096Abstract: Systems and methods for enhanced implantation of an electrode lead for neuromuscular electrical stimulation of tissue associated with control of the lumbar spine for treatment of back pain, in a midline-to-lateral manner are provided. The implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system without disruption of the electrode lead post-implantation due to anatomical structures.Type: GrantFiled: March 22, 2024Date of Patent: April 7, 2026Assignee: Mainstay Medical LimitedInventors: Jason Alan Shiroff, Henry Demorett, John Beck, Sidney Hauschild
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Patent number: 12594423Abstract: Occipital lobe stimulation device comprising normal looking glasses having a frame portion with side portions and lens portions, provided together with a battery-powered plurality of Light-Emitting Diodes (LEDs) fixed around an anterior periphery of the frame portion for emitting photons of light to reflect off of an object in the outside world, and a plurality of photoreceptors dispersed across and retained in the lens portions, the photoreceptors being connected via wires to corresponding inverters in the side portions which are also wire connected to output devices on a strap an enabling connection to corresponding input devices surgically implanted and connected to the user's occipital lobes, for transmitting image information relating to the object to the user's occipital lobes to enable the user's brain to make use of the information.Type: GrantFiled: March 8, 2024Date of Patent: April 7, 2026Inventor: Robert Alvord
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Patent number: 12582823Abstract: A system to provide flexible stimulation pattern definition, delivery, and control to dynamically adjust a therapy regimen for electrical stimulation therapy based on patient needs. Firmware in an electrical stimulation delivery device that executes the therapy regimen may be implemented as a “player” of a series of instructions for the received stimulation patterns. The system may include a wearable device or an implantable device. An external computing device configured to program the electrical stimulation delivery device may include a stimulation pattern construct collection from which a clinician can select, assemble, and modify waveforms, bursts, pattern, sensing or other event triggers etc. to create a therapy regimen. The external computing device may transmit software that defines the selected regimen to the electrical stimulation delivery device memory, where the device “plays” the instructions to deliver electrical stimulation according to the therapy regimen.Type: GrantFiled: March 3, 2023Date of Patent: March 24, 2026Assignee: Medtronic, Inc.Inventors: Benjamin P. Isaacson, Brett M. Nelson, Duane L. Bourget, Nicholas D. Buse, Laura A. Skarie, David E. Linde
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Patent number: 12582825Abstract: A system for adjusting neuromodulation parameters used by a neuromodulator operably connected to a plurality of electrodes to modulate a neural target, may comprise a translation trigger detector configured to determine that a translation trigger has occurred, a first parameter setting storage configured to store first parameter settings for use by the neuromodulator to modulate the neural target, and a neuromodulation parameter translator. The neuromodulation parameter translator may be operably connected to the translation trigger detector to automatically translate the first parameter settings into a second parameter settings in response to determining the translation trigger has occurred, and replace the first parameter settings with the second parameter settings, or store the second parameter settings in a second parameter setting storage.Type: GrantFiled: December 12, 2023Date of Patent: March 24, 2026Assignee: Boston Scientific Neuromodulation CorporationInventors: Richard Mustakos, Stephen Carcieri, Chirag Shah, Peter J. Yoo
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Patent number: 12576275Abstract: This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically balancing stimulation program duration.Type: GrantFiled: June 27, 2024Date of Patent: March 17, 2026Assignee: Advanced Neuromodulation Systems, Inc.Inventor: Christopher S. L. Crawford
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Patent number: 12576276Abstract: Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. The aggregate programs also include an amplitude modulation factor that modulates the amplitude defined by the pulse program. The inclusion of an amplitude modulation factor in the aggregate program allows complex amplitude-modulated waveforms to be produced. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.Type: GrantFiled: January 9, 2023Date of Patent: March 17, 2026Assignee: Boston Scientific Neuromodulation CorporationInventors: Philip Leonard Weiss, Pujitha Weerakoon, David Michael Wagenbach
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Patent number: 12564715Abstract: A temporomandibular joint (TMJ) disorder microcurrent treatment device and methods of operating the microcurrent device that includes a treatment electrode and at least one return electrode. The TMJ microcurrent treatment device may output and maintain a constant current treatment waveform.Type: GrantFiled: June 29, 2023Date of Patent: March 3, 2026Assignee: Tivic Health Systems Inc.Inventors: Blake Taylor Gurfein, John Claude, Christopher A. Wiklof
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Patent number: 12558547Abstract: The present technology is directed generally to spinal cord modulation and associated systems and methods for treating pain and other patient conditions. In particular, the present technology includes modified high frequency neuromodulation signals and administration patterns.Type: GrantFiled: May 25, 2022Date of Patent: February 24, 2026Assignee: Nevro Corp.Inventors: Dongchul Lee, Kerry Bradley
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Patent number: 12551402Abstract: The present disclosure relates to a method of displaying locations of acupuncture points in the human body using artificial intelligence and may provide a method of displaying locations of acupuncture points in the human body, which may convert the sizes of the joint points from an artificial intelligence deep-learning model (e.g., MediaPipe, etc.) to fit the subject body, calculate locations of acupuncture points on the hands, feet, face, body, etc. through vector calculation of the joint points, and display the same in real-time image on the subject body in augmented reality.Type: GrantFiled: October 26, 2023Date of Patent: February 17, 2026Assignee: PUKYONG NATIONAL UNIVERSITY INDUSTRY—UNIVERSITY COOPERATION FOUNDATIONInventors: Myunggi Yi, Jaewoong Han, Byeong-Il Lee
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Patent number: 12551274Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.Type: GrantFiled: May 24, 2024Date of Patent: February 17, 2026Assignee: Boston Scientific Scimed, Inc.Inventor: Steven R. Mickelsen
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Patent number: 12539413Abstract: An intravascular fluid movement device that includes an expandable member having a collapsed, delivery configuration and an expanded, deployed configuration, the expandable member having a proximal end and a distal end, a rotatable member disposed radially and axially within the expandable member, and a conduit coupled to the expandable member, the conduit at least partially defining a blood flow lumen between a distal end of the conduit and a proximal end of the conduit, the conduit disposed solely radially inside of the expandable member in a distal section of the expandable member.Type: GrantFiled: June 27, 2023Date of Patent: February 3, 2026Assignee: Shifamed Holdings, LLCInventors: Amr Salahieh, Claudio Argento, Tom Saul, Brady Esch, Colin Mixter, Peter Brown, Anna Kerlo, Daniel Hildebrand, Daniel Varghai
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Patent number: 12539425Abstract: This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.Type: GrantFiled: October 26, 2022Date of Patent: February 3, 2026Assignee: Medtronic, Inc.Inventors: Andrew L. Schmeling, Rebecca A. Miron, Christopher J. Edwards, David W. Simons, Nikita Tandon, Reid K. Bornhoft
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Patent number: 12533513Abstract: An electrical stimulation system and a method for controlling the electrical stimulation system are provided. The electrical stimulation system includes an electrical stimulation unit including at least one first fastener and an electrode pad configured to attach to the at least one first fastener via at least one second fastener located within the electrode pad, where the electrode pad includes at least one electrode. Further, the electrical stimulation system includes a controller remotely controlling the electrical stimulation unit to deliver electrical pulses to the electrode pad connected to the electrical stimulation unit.Type: GrantFiled: May 4, 2022Date of Patent: January 27, 2026Assignee: HI-DOW IPHC, INC.Inventor: Eric Ye Chen
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Patent number: 12521550Abstract: A method of providing therapy to a patient according to one embodiment includes generating an electrical noise signal by at least one noise generator controlled by a controller of a tunable noise system, partitioning the electrical noise signal into a plurality of discrete frequency bands, each of the discrete frequency bands having a corresponding bandwidth, delivering the electrical noise signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or current of the electrical noise signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted electrical signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.Type: GrantFiled: September 25, 2023Date of Patent: January 13, 2026Assignee: Soin Neuroscience, LLCInventors: Eric A. Schepis, Amol Soin
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Patent number: 12515077Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.Type: GrantFiled: September 9, 2021Date of Patent: January 6, 2026Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Serge Picaud, Sara Cadoni, José-Alain Sahel, Mickaël Tanter, Charlie Demene
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Patent number: 12515041Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.Type: GrantFiled: February 10, 2022Date of Patent: January 6, 2026Assignee: SynerFuse, Inc.Inventors: Michael Park, Matthew Hunt, Nazmi Peyman, Justin D. Zenanko, Christopher G. Frank, Beth A. Lindborg, Kyle Grube, Kathy Hill, Gregory F. Molnar
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Patent number: 12502540Abstract: Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals, including spinal cord stimulation or peripheral nerve stimulation.Type: GrantFiled: November 8, 2021Date of Patent: December 23, 2025Assignee: Medtronic SG, LLCInventors: Ricardo Vallejo, David Leonardo Cedeno, Nathan A. Torgerson, Brian Andrew Smith
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Patent number: 12496447Abstract: Systems and methods are provided for combined ultrasound and electrical stimulation for treating inflammation, autoimmune disorders, rheumatoid arthritis, and the like. Noninvasive ultrasound stimulation may be applied to the spleen, joints, limbs, or a region experiencing pain that has local swelling, and electrical stimulation may be applied to the face, neck, or other body region to access a peripheral nerve, vagus nerve, trigeminal nerve, or other nerves in appropriately-timed patterns to drive therapeutic effects. Stimulation timings or delay timings may be optimized based upon a desired clinical effect or treatment. Multiple targets may be stimulated in a coordinated fashion to better mimic natural physiology. A wearable ultrasound phased array device may be used to beam form energy to target the spleen while also having imaging capabilities to track the motion of the spleen to maintain localized stimulation of target regions.Type: GrantFiled: March 10, 2020Date of Patent: December 16, 2025Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Hubert Lim, Daniel Zachs, Claire Kaiser
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Patent number: 12485273Abstract: An algorithm for determining optimal sub-perception stimulation parameters for a Spinal Cord Stimulation patient is disclosed. The algorithm uses various modelling information, including a model determined based on empirical testing that relates optimal frequencies and pulse widths with perception thresholds reported by patients at those frequencies and pulse widths. A patient's perception threshold is then measured at different pulse widths, with the result compared to the model to determine a range or volume in the model that best relates frequency pulse width and perception threshold for that patient. Further modeling allows the perception thresholds to be related to an optimal amplitudes, thus resulting in optimal situation parameters (F, PW, and A) for the patient. The optimal stimulation parameters may be provided to a patient's external controller to allow the patient to adjust stimulation within a range of volume of these parameters.Type: GrantFiled: July 2, 2019Date of Patent: December 2, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Ismael Huertas Fernandez, Que T. Doan
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Patent number: 12484853Abstract: One example of a system includes a local user system to interact with an implantable medical device and a local input device communicatively coupled to the local user system to generate local events. To operate the local user system, the local user system is to receive local events from the local input device and remote events from a remote user system communicatively coupled to the local user system via a medical device remote access system. The local user system is to process a local event and ignore a remote event in response to receiving a local event and a remote event simultaneously.Type: GrantFiled: December 21, 2023Date of Patent: December 2, 2025Assignee: Medtronic, Inc.Inventors: Corey E Ney, Kent D Magaard
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Patent number: 12478780Abstract: A percutaneous lead is provided which includes a generally tubular, multi-duct, flexible lead body. The lead body supports a distal set of electrodes and a proximal set of contacts which are connected by conductors in the ducts. The lead body further houses an optical fiber with a side firing section. The side firing section is held adjacent an optical transmission window, integrally formed with the flexible lead body. A cylindrical ferrule is provided to position the fiber in the header of an IPG.Type: GrantFiled: February 5, 2024Date of Patent: November 25, 2025Assignee: Wavegate CorporationInventor: Erich W. Wolf, II
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Patent number: 12478777Abstract: In various embodiments, methods are provided to improve motor function, and/or to improve motor control, and/or to improve sensory function, and/or to reduce pain in subjects with nerve root palsies (e.g., radiculopathies including, but not limited to cauda equina syndrome). In certain embodiments, methods are provided for the magnetic stimulation of the spinal cord or regions thereof to improve motor function of upper and/or lower extremities in subjects with impaired extremity motor function due to spinal cord or brain injury or pathology.Type: GrantFiled: August 22, 2019Date of Patent: November 25, 2025Assignee: The Regents of the University of CaliforniaInventor: Daniel C. Lu
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Patent number: 12472347Abstract: A method includes configuring, by a computing device, stimulation settings for each electrode in an at least one electrode array in physical contact with a patient, the stimulation settings having adjustable parameters comprising frequency, pulse width, and amplitude, obtaining, by the computing device, feedback information from the patient, and automatically adjusting, by the computing device, at least one of the adjustable parameters based on the feedback information from the patient.Type: GrantFiled: June 30, 2021Date of Patent: November 18, 2025Assignee: Salvia BioElectronics B.V.Inventors: Daniel Schobben, Hubert Martens
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Patent number: 12472365Abstract: The present disclosure is directed to providing digital health services. In some embodiments, systems and methods for conducting virtual or remote sessions between patients and clinicians are disclosed. During the sessions, media content (e.g., images, video content, audio content, etc.) may be captured as the patient performs one or more tasks. The media content may be presented to the clinician and used to evaluate a condition of the patient or a state of the condition, adjust treatment parameters, provide therapy, or other operations to treat the patient. The analysis of the media content may be aided by one or more machine learning/artificial intelligence models that analyze various aspects of the media content, augment the media content, or other functionality to aid in the treatment of the patient.Type: GrantFiled: August 18, 2022Date of Patent: November 18, 2025Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Mary Khun Hor-Lao, Binesh Balasingh, Scott DeBates, Douglas Alfred Lautner
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Patent number: 12472366Abstract: The present disclosure is directed to providing digital health services. In some embodiments, systems and methods for conducting virtual or remote sessions between patients and clinicians are disclosed. During the sessions, media content (e.g., images, video content, audio content, etc.) may be captured as the patient performs one or more tasks. The media content may be presented to the clinician and used to evaluate a condition of the patient or a state of the condition, adjust treatment parameters, provide therapy, or other operations to treat the patient. The analysis of the media content may be aided by one or more machine learning/artificial intelligence models that analyze various aspects of the media content, augment the media content, or other functionality to aid in the treatment of the patient.Type: GrantFiled: August 18, 2022Date of Patent: November 18, 2025Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Mary Khun Hor-Lao, Binesh Balasingh, Scott DeBates, Douglas Alfred Lautner, Yagna Pathak, Simeng Zhang, Diane Whitmer, Anahita Kyani, Hyun-Joo Park, Erika Ross, David Page, Ameya Nanivadekar, Dehan Zhu
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Patent number: 12476784Abstract: A system and method of clock and data recovery. In some embodiments, the method includes: setting a bias signal source to a first bias value, the bias signal source being connected to an input of a voltage-controlled oscillator of a clock and data recovery circuit; determining that a locked signal of a frequency feedback signal source equals a first feedback value; setting the bias signal source to a second bias value, different from the first bias value; determining that a locked signal of the frequency feedback signal source equals a second feedback value; determining that the second feedback value meets a termination criterion; and setting an operating value of the bias signal source to the second bias value.Type: GrantFiled: October 4, 2023Date of Patent: November 18, 2025Assignee: Samsung Electronics Co., Ltd.Inventors: Michael Chung Wang, Neal Hays, Amir Amirkhany
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Patent number: 12472355Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the trigeminal nerve. A system comprises one or more electrodes configured for contacting an outer skin surface of a patient and a stimulator coupled to the one or more electrodes. The stimulator is configured to transmit an electrical impulse from the electrodes through the outer skin surface to a target site within a patient. A software application coupled to the stimulator. The software application may, for example, be downloadable onto a mobile device and may allow the user to transmit data to and from the stimulator and/or control operation of the stimulator.Type: GrantFiled: May 25, 2023Date of Patent: November 18, 2025Assignee: ElectroCore, Inc.Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
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Patent number: 12465768Abstract: A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.Type: GrantFiled: June 14, 2023Date of Patent: November 11, 2025Assignee: The Feinstein Institutes for Medical ResearchInventors: Stavros Zanos, Yao-Chuan Chang
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Patent number: 12465767Abstract: The present technology provides systems and methods for directly suppressing nerve cells by delivering electrical stimulation having relatively long pulse widths and at amplitudes below an activation threshold of the nerve cells. For example, some embodiments include delivering a therapy signal having individual pulses with pulse widths of between about 5 ms and 100 ms. Directly suppressing the nerve cells is expected to reduce the transmission of pain signals.Type: GrantFiled: October 13, 2023Date of Patent: November 11, 2025Assignee: NEVRO CORP.Inventors: Kerry Bradley, Dongchul Lee
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Patent number: 12453862Abstract: The present disclosure is directed to providing digital health services. In some embodiments, systems and methods for conducting virtual or remote sessions between patients and clinicians are disclosed. During the sessions, media content (e.g., images, video content, audio content, etc.) may be captured as the patient performs one or more tasks. The media content may be presented to the clinician and used to evaluate a condition of the patient or a state of the condition, adjust treatment parameters, provide therapy, or other operations to treat the patient. The analysis of the media content may be aided by one or more machine learning/artificial intelligence models that analyze various aspects of the media content, augment the media content, or other functionality to aid in the treatment of the patient.Type: GrantFiled: August 18, 2022Date of Patent: October 28, 2025Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Mary Khun Hor-Lao, Binesh Balasingh, Scott DeBates, Douglas Alfred Lautner
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Patent number: 12447351Abstract: An adapter configured to electrically connect a test device to an implantable medical lead comprises a rotational electrical coupling. The rotational electrical coupling is configured to electrically connect a lead electrical connector to an adapter electrical connector. The rotational electrical coupling comprises a first conductive component configured to be electrically connected to the lead electrical connector and rotatable with a proximal portion of the implantable medical lead, and a second conductive component electrically connected to the first conductive component and the adapter electrical connector. The second conductive component may be rotationally fixed. The first and second conductive components may comprise graphite or another soft metal.Type: GrantFiled: February 20, 2024Date of Patent: October 21, 2025Assignee: Medtronic, Inc.Inventors: Zhongping Yang, Thomas A. Anderson, Wade M. Demmer, Xiaohong Zhou
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Patent number: 12447337Abstract: This document discusses, among other things, systems and methods for providing pain relief to a patient. Recording circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to external stimulation of a location where the patient is experiencing pain. The received electrical signals may be stored in a memory. Internal stimulation may then be applied to the patient and control circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to the internal stimulation. The control circuitry may then adjust electrical parameters of the internal stimulation, such as to reduce a difference between the electrical signals corresponding to evoked compound action potentials produced in response to the internal stimulation and electrical signals corresponding to evoked compound action potentials produced in response to the external stimulation.Type: GrantFiled: March 16, 2021Date of Patent: October 21, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Natalie A. Brill, Rosana Esteller
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Patent number: 12450513Abstract: Quantum algorithms are performed via a quantum computer, by generating a quantum control pulse in a quantum controller and transmitting the quantum control pulse to a quantum processor. The quantum control pulse interacts with a qubit in the quantum processor. Within the quantum controller, a pulse processor generates a plurality of raw pulses that are modified by a front end hardware module. During the normal operation of the quantum controller, samples of the raw and/or modified pulses may be selected and saved to memory. During a design for validation (DFV) mode, the proper operation of the quantum controller is determined according to a simulation of the quantum controller and the saved samples. The DFV mode may be performed in parallel with normal operation without affecting the resources of the quantum controller.Type: GrantFiled: May 31, 2022Date of Patent: October 21, 2025Assignee: Q.M Technologies Ltd.Inventors: Ori Weber, Tamar Ben Haim Sembira, Lior Ella, Yonatan Cohen, Nissim Ofek, Itamar Sivan
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Patent number: 12434050Abstract: Intraoral neuromodulation for the treatment clinical conditions such as, e.g., dysphagia, migraines, or speech problems can be achieved with a neuromodulation system that includes an intraoral neural stimulator, e.g., integrated into a wearable device to be positioned in the oral cavity, that is controlled based on one or more measured signals associated with an intraoral organ or nerve related to the clinical condition.Type: GrantFiled: December 20, 2019Date of Patent: October 7, 2025Assignee: The Texas A&M University SystemInventors: Saurabh Biswas, Hangue Park
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Patent number: 12426819Abstract: A multi-channel micro peripheral nerve sensor for measuring a neurosignal with low noise is proposed. The multi-channel micro peripheral nerve sensor may include a substrate, an analog-digital (AD) converter, and a signal acquisition unit. The substrate may be combined with each cut surface of a severed nerve and include channels into which nerve cells are inserted. The AD converter may be combined with the substrate, be electrically connected to the channels, receive analog neurosignals from the nerve cells, and convert the analog neurosignals into digital signals. The signal acquisition unit may be electrically connected to the AD converter and acquire the digital signals from the AD converter.Type: GrantFiled: December 28, 2022Date of Patent: September 30, 2025Assignee: Korea Electronics Technology InstituteInventors: Kyusik Shin, Cheolung Cha, Yunjae Won
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Patent number: 12420099Abstract: Systems, apparatuses, and methods described herein facilitate the placement of spinal cord stimulator (SCS) electrode in relationship to neural tissue of the spinal cord based on electromyography (EMG) data. The systems, apparatuses, and methods are designed to assist physicians and surgeons target specific neurophysiological locations through stimulation and subsequent visualization of EMG activity in response to stimulation to more precisely identify the location of the SCS electrodes that will maximize the intended therapeutics effects of SCS.Type: GrantFiled: October 21, 2024Date of Patent: September 23, 2025Assignee: Cartis Neuro, Inc.Inventors: Rahul Gole, Sam Perlmutter, Karthik Seshan
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Patent number: 12409322Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.Type: GrantFiled: June 21, 2022Date of Patent: September 9, 2025Assignees: The Regents of the University of California, Presidio Medical, Inc.Inventors: Jeffrey Laurence Ardell, Kalyanam Shivkumar, Arun Sridhar
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Patent number: 12409318Abstract: Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.Type: GrantFiled: July 8, 2024Date of Patent: September 9, 2025Assignee: Saluda Medical Pty LtdInventor: John Louis Parker
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Patent number: 12408979Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.Type: GrantFiled: May 24, 2024Date of Patent: September 9, 2025Assignee: Boston Scientific Scimed, Inc.Inventor: Steven R. Mickelsen
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Patent number: 12403320Abstract: The invention is a head part of an implantable device, method of production thereof and a plug which can be fitted into the head part. The head part comprises a housing which has at least one blind hole plug contact socket with a socket opening as well as a socket base axially opposite the socket opening, along which at least one electrically conductive contact ring element and an electrically insulating, elastically deformable sealing ring, which are enclosed by a solidified casting compound, are joined together coaxially axially. Arranged within the head part is at least one second blind hole plug contact socket with a socket opening as a socket base axially opposite the socket opening, along which at least one electrically conductive contact ring element and an electrically insulating, elastically deformable sealing ring is located, which are enclosed by the solidified casting compound, are joined together in a coaxial arrangement and in an axially serial sequence.Type: GrantFiled: May 4, 2021Date of Patent: September 2, 2025Assignee: Neuroloop GmbHInventors: Fabian Kimmig, Tim Boretius
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Patent number: 12390639Abstract: A patient treatment unit for delivering non-invasive pulsed energy to living tissue with a probe stimulus generator circuit configured to output, as a treatment signal, a sequence of DC electrical pulses at a controlled pulse frequency of about 20 kHz and having a pulse voltage defined by a variable supply voltage of the probe stimulus generator circuit. The unit includes primary and secondary probes for contacting a body, an intensity adjustment circuit configured to control the variable supply voltage, and an electronic timer display configured to display an elapsed time in decimal numbers in minute and second format. An electrical current of the pulses is in a range of 0.1-2 mA while the probes are contacting the body. An operating output voltage across the probes while conducting the treatment signal does not exceed a maximum operating output voltage of 165 VDC while the probes are contacting the body.Type: GrantFiled: April 27, 2023Date of Patent: August 19, 2025Assignee: TRUERELIEF, LLCInventor: John Crosson