Electrical Treatment Of Pain Patents (Class 607/46)
  • Patent number: 10722715
    Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: July 28, 2020
    Assignee: SPR Therapeutics, Inc.
    Inventors: Maria E. Bennett, Joseph W. Boggs, Warren M. Grill, John Chae
  • Patent number: 10688306
    Abstract: The present technology provides a medical stimulation system having a clinical programmer configured to operate on a computational and memory device having a wireless communication device. The technology also provides a neurostimulator configured to wirelessly communicate with the clinical programmer. The neurostimulator also includes a pulse generator operatively coupled with an electrode by a lead. The pulse generator is configured to transmit an electrical signal comprising a repeating succession of non-regular pulse trains. Each pulse train includes a plurality of pulses having non-regular, non-random, differing inter-pulse intervals therebetween. The pulse trains repeat in succession to treat a neurological condition. Further, the pulse trains are initiated by instructions communicated by the clinical programmer.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: June 23, 2020
    Assignee: Deep Brain Innovations LLC
    Inventors: Robert Strother, Jonathan Sakai, Geoffrey Thrope
  • Patent number: 10675458
    Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: June 9, 2020
    Assignee: SynerFuse, Inc.
    Inventors: Gregory F. Molnar, Christopher G. Frank, Justin D. Zenanko, Beth A. Lindborg, Nazmi Peyman, Kyle Grube, Michael Park, Matthew Hunt, Kathy Hill
  • Patent number: 10661078
    Abstract: Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 26, 2020
    Assignee: Mainstay Medical Limited
    Inventors: Peter Andrew Crosby, Dan Sachs, Prashant Brijmohansingh Rawat, Jason Alan Shiroff, Johannes Petrus Heemels
  • Patent number: 10653884
    Abstract: A controller for implementing a method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, where such arbitrary waveforms can also be used for charge balancing purposes.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 19, 2020
    Assignee: NUVECTRA CORPORATION
    Inventors: Stephen C. Trier, Jeffrey A. Weisgarber, Richard J. Polefko, David J. Howard
  • Patent number: 10646708
    Abstract: Described herein are methods and apparatuses for the application of transdermal electrical stimulation (TES). The apparatuses described herein include neck-worn devices having electrodes (or configured to connect to electrodes, including automatically self-connecting to electrodes) adapted to couple to the midline of the back of user's neck. A neck-worn controller may be configured as a cord, band, wire, torc, necklace, loop, strap, or the like, and may be rigid or semi-rigid and may be worn at least partially around the subject's neck. The controller may controllably apply one or more waveforms to the electrodes of the electrode pad (e.g., patch) to deliver TES adapted to treat a disorder (e.g., psoriasis) and/or to induce or enhance a relaxed cognitive state.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: May 12, 2020
    Assignee: Thync Global, Inc.
    Inventors: Isy Goldwasser, Douglas Jeffery, Sumon K. Pal, Wing Law
  • Patent number: 10639480
    Abstract: In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 5, 2020
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Harshit Suri, Edward K. F. Lee
  • Patent number: 10632307
    Abstract: Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: April 28, 2020
    Assignee: Saluda Medical Pty Ltd
    Inventor: John Louis Parker
  • Patent number: 10631777
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a motion sensor configured to sense at least one functional signal indicative a physical state of the subject. The at least one functional signal may include at least one motor activity signal or at least one sleep state signal. A pain analyzer circuit may extract, from the functional signal, signal metrics indicative of subject motor control or kinetics, and generate a pain score using the signal metrics. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver a closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: April 28, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu, Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, James John Kleinedler, David J. Ternes
  • Patent number: 10631776
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a sensor circuit configured to sense a respiration signal and a heart rate signal. A pain analyzer circuit may determine respiratory cycles and respiratory phases in a respiratory cycle, and generate one or more signal metrics indicative of respiration-mediated heart rate variation. The pain analyzer may generate a pain score using the signal metrics indicative of respiration-mediated heart rate variation. The pain score may be output to a user or a process. The system may include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: April 28, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Kyle Harish Srivastava
  • Patent number: 10617872
    Abstract: This document discusses, among other things, systems and methods for programming a neuromodulation therapy to treat neurological or cardiovascular diseases. A system includes an ambulatory medical device (AMD) and at least one computer-readable storage medium including instructions executable on an external system. The instructions, when executed by the external system, causes a user interface in the external system to receive a waveform function and one or more modulation parameter values. The waveform function includes one or more modulation programs characterized by one or more modulation parameters. The instructions causes a compiler to translate the waveform function into virtual machine (VM) instructions, which can be transmitted to the AMD. The AMD includes a VM that executes the VM instructions, and generates one or more modulation waveform datasets. The AMD may generate and deliver electrostimulation therapy in accordance with the one or more modulation waveform datasets.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: April 14, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Goran N. Marnfeldt
  • Patent number: 10617871
    Abstract: A therapeutic neurostimulation system configured for providing therapy to a patient. The neurostimulation system comprises a neurostimulation lead having an array of electrodes arranged along a longitudinal axis configured for being implanted along a spinal cord of a patient, a neurostimulation device configured for delivering electrical stimulation energy to active ones of the electrode array, and control/processing circuitry for instructing the neurostimulation device to configure an active electrode as a cathode, and two active electrodes longitudinally flanking and laterally offset from the cathode as anodes, selecting a ratio of stimulation amplitude values for the two anodes based on a known longitudinal location of the implanted neurostimulation lead relative to the spinal cord, and instructing the neurostimulation device to distribute the electrical stimulation energy between the two anodes in accordance with the selected stimulation amplitude value ratio.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: April 14, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Emarit A. S. Ranu
  • Patent number: 10610688
    Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: April 7, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth M. Annoni
  • Patent number: 10596378
    Abstract: Disclosed are methods of treating depression, mania, post-traumatic stress disorder (PTSD), and various other neurologic conditions using synaptic pathway training. Methods of synaptic pathway training include, generally, achieving a favorable treatment result by activating a synaptic pathway using a pharmacologic agent, such as treating refractory symptoms of depression with ketamine, following by potentiation of the favorable result by repeatedly stimulating the activated pathway. Stimulation of a synaptic pathway may be achieved by intrinsic means, such as performance of cognitive exercised, or extrinsic means, such as by delivery of a sensory stimulus to the patient, placing a potential voltage difference across the brain or a brain region, or by placing the brain or a brain region in a magnetic field.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: March 24, 2020
    Inventor: Joseph Rustick
  • Patent number: 10576286
    Abstract: Short pulse width spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, modulation signal has pulse widths in the range of from about 10 microseconds to about 50 microseconds may be applied to the patient's spinal cord region to address chronic pain without using paresthesia or tingling to mask or cover the patient's sensation of pain. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: March 3, 2020
    Assignee: Nevro Corp.
    Inventor: Sangsoo Wesley Park
  • Patent number: 10576279
    Abstract: The present invention provides a device for the transcutaneous electrical stimulation of the trigeminal nerve.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: March 3, 2020
    Assignee: Cefaly Technology SPRL
    Inventors: Pierre-Yves Muller, Pierre Rigaux
  • Patent number: 10576264
    Abstract: Presented herein are implantable medical devices, such as tissue-stimulating prostheses, that are configured to deliver simultaneous stimulation to a recipient. In one embodiment, a tissue stimulating prosthesis comprises a plurality of current sources, a plurality of electrodes (e.g., a linear array of electrodes), and a hardwired electrical network of switches, sometimes referred to herein as a “sparse switch network.” The sparse switch network is configured to connect each of the current sources to more than one of the electrodes, and to connect each of the electrodes to only a subset of the current sources. The sparse switch network is configured to prevent adjacent electrodes from being connected to the same current source.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 3, 2020
    Assignee: COCHLEAR LIMITED
    Inventors: Torsten Lehmann, Tony Mikael Nygard
  • Patent number: 10576282
    Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: March 3, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
  • Patent number: 10576265
    Abstract: Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. Each steering program defines the stimulation polarity and the allocation of current of the specified stimulation polarity for each of the pulse generator's electrodes. Each pulse program includes one or more pulse instructions, where each instruction defines the parameters of a single phase of the pulse program. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: March 3, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Philip Leonard Weiss, Goran N. Marnfeldt, David Michael Wagenbach
  • Patent number: 10569083
    Abstract: A motor device for stimulating muscle, including at least one electrode for generating electric current operatively attached to an electrode array and exposed on an inner surface of an array body, and a programming mechanism of a computer that executes an algorithm stored on non-transitory computer readable medium and includes an information storage mechanism and a user-operated interface in electrical connection with said at least one electrode for programming operation of said at least one electrode, said motor device being implanted in an individual and applying electric current to nerves at an area above an area of neurological damage.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: February 25, 2020
    Assignee: IINN, Inc.
    Inventor: Jawad A. Shah
  • Patent number: 10569089
    Abstract: Short pulse width spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, modulation signal has pulse widths in the range of from about 10 microseconds to about 50 microseconds may be applied to the patient's spinal cord region to address chronic pain without using paresthesia or tingling to mask or cover the patient's sensation of pain. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: February 25, 2020
    Assignee: Nevro Corp.
    Inventor: Sangsoo Wesley Park
  • Patent number: 10561845
    Abstract: An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: February 18, 2020
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Peter J. Kovach, Warren W. Ball, Jonathan C. Werder, Nina M. Graves, David C. Ullestad, Sarah B. Alme
  • Patent number: 10556112
    Abstract: Short pulse width spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, modulation signal has pulse widths in the range of from about 10 microseconds to about 50 microseconds may be applied to the patient's spinal cord region to address chronic pain without using paresthesia or tingling to mask or cover the patient's sensation of pain. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: February 11, 2020
    Assignee: Nevro Corp.
    Inventor: Sangsoo Wesley Park
  • Patent number: 10556108
    Abstract: A multichannel apparatus to stimulate Vagus nerves is provided. The multichannel apparatus includes a first pair of electrodes attached to an earlobe of a right external ear. A second pair of electrodes are attached to an earlobe of a left external ear. A third pair of electrodes are attached to a cymba conchae of the right external ear. A controller manages the first, second, and third pair of electrodes. The controller activates or deactivates the first, second and third electrodes; expels pulses to the right and left external ears; and provides a stimulation treatment to the Vagus nerves associated with the right and left external ears.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: February 11, 2020
    Inventors: Yakov Katsnelson, Hank Beckhoff, Alexander Stuchenkov, Vladimir Chuev
  • Patent number: 10556104
    Abstract: The disclosure is directed to securing electrodes of a medical lead adjacent to a target tissue site. The medical lead may include at least one adhesive element disposed along a longitudinal outer surface of the lead body to adhere the adjacent tissue to the lead. Adhesive elements may be disposed proximal to, distal to, or in-between the electrodes of the lead. Each adhesive element may be inactive during lead implantation and activated by removing a covering sheath to expose the adhesive elements to moisture in the tissue or presenting an energy, e.g. ultraviolet light, to the adhesive elements. Once active, the adhesive elements secure the lead to surrounding tissue to prevent migration of the electrodes from the target tissue.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: February 11, 2020
    Assignee: Medtronic, Inc.
    Inventor: Martin T. Gerber
  • Patent number: 10549091
    Abstract: Current generation circuitry for an Implantable Pulse Generator (IPG) is disclosed. The IPG comprises a plurality of PDACs and NDACs for souring currents to electrode nodes. The PDACs and NDACs can be configured as pairs to each provide stimulation in independent timing channels, or the PDACs can be combined and the NDACs can be combined to provide stimulation in a single timing channel. Further, the PDAC or NDAC can provide a plurality of source branch currents each of the same amplitude to the electrodes via a switch matrix, and pulse definition circuitry can be configured to always connect each of the source branch currents to one of the first one or more electrode nodes via the switch matrix.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: February 4, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pujitha Weerakoon, Goran N. Marnfeldt, Philip L. Weiss
  • Patent number: 10537728
    Abstract: Devices, systems and methods are disclosed for treating or preventing a stroke and/or a transient ischemic attack in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. Vagus nerve stimulation is used to modulate the release of GABA, norepinephrine, and/or serotonin, thereby providing neuroprotection to the patient; to modulate the activity of resting state neuronal networks, particularly the sensory-motor network or resting state networks containing the insula; and to avert a stroke or transient ischemic attack that has been forecasted.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: January 21, 2020
    Assignee: ElectroCore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 10537729
    Abstract: Trigeminal nerves are stimulated based upon pulse counting and chronobiology. A cutaneous electrode assembly is applied to the forehead to stimulate the ophthalmic nerves. A method may include determining a number of pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves with the determined number of pulses. Another method may include determining a pulse repetition frequency for pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: January 21, 2020
    Assignee: NEUROSIGMA, INC.
    Inventors: Ian A. Cook, Colin Kealey
  • Patent number: 10525266
    Abstract: An example of a system may include an electrode arrangement, a neural modulation generator configured to use electrodes in the electrode arrangement to generate a modulation field, a communication module configured to receive commands, a memory configured to store modulation field parameter data, and a controller configured to control the neural modulation generator to generate the modulation field. The controller may be configured to implement a trolling routine to troll the modulation field through neural tissue positions, and implement a marking routine multiple times as the modulation field is trolled through the neural tissue positions to identify when the modulation field provides patient-perceived modulation.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: January 7, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, Bradley Lawrence Hershey, Changfang Zhu, Jordi Parramon, Sridhar Kothandaraman
  • Patent number: 10525254
    Abstract: A windowed electrode assembly includes a foam layer having windows. Each window receives a corresponding gel pad that is sized such that it is contained by the window's sidewalls. The windowed electrode assembly includes a foam backing layer that forms a back wall for the windows such that each gel pad is encased by the window's sidewalls and back wall.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 7, 2020
    Assignee: NEUROSIGMA, INC.
    Inventor: Patrick Miller
  • Patent number: 10507325
    Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: December 17, 2019
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10507328
    Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, a user interface configured for receiving input from a user that selects one of a plurality of different shapes of a modulating signal and/or selects one of a plurality of different electrical pulse parameters of an electrical pulse train, neuromodulation output circuitry configured for outputting an electrical pulse train to the plurality of electrical terminals, and pulse train modulation circuitry configured for modulating the electrical pulse train in accordance with the selected shape of the modulating signal and/or selected electrical pulse parameter of the electrical pulse train.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: December 17, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Changfang Zhu
  • Patent number: 10500399
    Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: December 10, 2019
    Assignee: Saluda Medical Pty Ltd
    Inventor: Peter Scott Vallack Single
  • Patent number: 10493275
    Abstract: Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: December 3, 2019
    Assignee: Nevro Corp.
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker
  • Patent number: 10471260
    Abstract: An example of a system for applying neuromodulation to a patient includes a modulation output circuit and a modulation control circuit. The modulation output circuit may be configured to deliver dorsal horn stimulation. The modulation control circuit may be configured to control the delivery of the dorsal horn stimulation by executing a neuromodulation algorithm using modulation parameters. The modulation control circuit may include a response input and a parameter calibrator. The response input may be configured to receive response information indicative of one or more responses to the stimulation of the dorsal horn. The parameter calibrator may be configured to adjust one or more of the modulation parameters using the response information.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: November 12, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Bradley Lawrence Hershey, Changfang Zhu
  • Patent number: 10463857
    Abstract: A spinal cord modulation system is disclosed. While in one embodiment the system is used for the treatment of pain, other embodiments are also provided. In particular embodiments, the spinal cord modulation system generates and delivers an electrical therapy signal at a frequency in the range of from about 5 kHz to about 15 kHz to address pain without creating unwanted sensory and/or motor side effects. The system may further include various signal delivery devices to deliver the therapy signal to a patient's spinal cord region.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 5, 2019
    Assignee: Nevro Corp.
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker, Yougandh Chitre, Sangsoo Wesley Park, James R. Thacker
  • Patent number: 10463858
    Abstract: Some implementations provide a method for treating craniofacial pain in a patient, the method including: placing a wirelessly powered passive device through an opening into a target site in a head or neck region of the patient's body, the wirelessly powered passive device configured to receive an input signal non-inductively from an external antenna; positioning the wirelessly powered passive device adjacent to or near a nerve at the target site; and causing neural modulation to the nerve through one or more electrodes on the wirelessly powered passive device.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 5, 2019
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Chad Andresen
  • Patent number: 10456575
    Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: October 29, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Kevin Kilgore, Douglas Michael Ackermann, Jr., Niloy Bhadra, Narendra Bhadra, Joe Payer
  • Patent number: 10456583
    Abstract: A neuromodulation device is configured with a set of testing program configuration instructions including therapeutic neuromodulation field-setting parameters. The device determines a custom priming program in response to the testing program configuration instructions. The custom priming program controls the neuromodulation device to generate a priming field with specific correspondence to the therapeutic neuromodulation field to be produced by the testing program.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: October 29, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Bradley Lawrence Hershey, Changfang Zhu
  • Patent number: 10449358
    Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 22, 2019
    Assignee: SetPoint Medical Corporation
    Inventors: Jacob A. Levine, Michael A. Faltys, Ralph J. Zitnik
  • Patent number: 10449371
    Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to generate a user interface to receive a therapy efficacy indication from a human subject for an neurostimulation treatment, receive user input in the user interface to select a therapy efficacy indication of the neurostimulation treatment, and identify a modification to a neurostimulation program based on the user input. For example, a therapy efficiency indication received in the user interface may indicate a perceived stimulation intensity, a perceived pain level, and a perceived location characteristic of the neurostimulation treatment. Based on the therapy efficacy indication and other user input in the graphical user interface, an updated setting to modify a parameter setting and implement a change to the neurostimulation treatment with a neurostimulation device can be provided.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Raul Enrique Serrano Carmona
  • Patent number: 10441787
    Abstract: The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. The signal is able to treat bronchoconstriction and prevent and/or ameliorate bronchoconstriction.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: October 15, 2019
    Assignees: GALVANI BIOELECTRONICS LIMITED, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Brendan J. Canning, Michael John Carr, Marian Kollarik
  • Patent number: 10441801
    Abstract: A programming-device user interface may include multiple levels of abstraction for programming treatment settings. A stimulation zone-programming interface may be at a highest level of abstraction and may include idealized stimulation zones. A field strength-programming interface may be at a middle level of abstraction and may include electromagnetic field-strength patterns generated by the stimulation zones, and/or electrode settings, and a depiction of how the electromagnetic fields interact with each other. An electrode-programming interface may be at a lowest level of abstraction and may depict treatment settings at an electrodes-view level. These interfaces may include a display of a stimulatable area of the patient's body. The display may include a depiction of leads and/or the underlying physiology, such as a depiction of a portion of a spine. Algorithms map treatment settings from one level of abstraction to settings at one or more other levels of abstraction.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 15, 2019
    Assignee: Medtronic, Inc.
    Inventor: Steven M. Goetz
  • Patent number: 10420938
    Abstract: A method of operating an implantable neuromodulator coupled to an electrode array implanted adjacent tissue of a patient having a medical condition comprises conveying electrical modulation energy to tissue of the patient in accordance with a modulation parameter set, wherein conveying the electrical modulation energy to tissue of the patient in accordance with the modulation parameter set stimulates dorsal horn neuronal elements more than dorsal column neuronal elements.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 24, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Changfang Zhu, Michael A. Moffitt, Bradley Lawrence Hershey
  • Patent number: 10420944
    Abstract: A device is provided for stimulating neurons that includes an implantable stimulation unit that generates stimuli in multiple stimulation elements. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation elements. Moreover, the device includes a control unit that controls the stimulation unit to repeatedly generates sequences of the stimuli with the order of the stimulation elements in which stimuli are generated within a sequence being constant for 20 or more successively generated sequences before it is varied.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: September 24, 2019
    Assignee: FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: Peter Alexander Tass, Magteld Zeitler
  • Patent number: 10413719
    Abstract: A method for treating pain or discomfort in a patient is disclosed. The method comprises stimulating a cranial nerve with an electrical signal. The pain or discomfort may be a withdrawal symptom. The cranial nerve may be in an auricular area of the patient. The cranial nerve may be cranial nerve V, cranial nerve VII, cranial nerve IX, cranial nerve X, or branches of greater and lesser occipital nerves thereof and their associated neurovascular bundles. The withdrawal symptom may result from cessation of an opioid. The method may further comprise administering a secondary drug treats one or more of the withdrawal symptoms and addiction. The secondary drug may be administered about one day to about one week after initiating the stimulating step.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 17, 2019
    Assignee: Innovative Health Solutions, Inc.
    Inventors: Christopher R. Brown, Gary M. Peterson
  • Patent number: 10406365
    Abstract: A regenerative interface electrode comprising a multilayer or sandwiched stack of dies that are oriented at their distal ends with at least one layer inset such that it forms a groove into which a nerve may be positioned inside the groove. The die layers include electrodes that connect to the nerve, allowing the nerve to be modulated. The electrodes in the die layers are connected to a PCB, which may communicate with a recording device. The distal end of the sandwiched die layers forming the groove is inserted into a nerve tube, into which the nerve is inserted.
    Type: Grant
    Filed: March 14, 2015
    Date of Patent: September 10, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Young-Tae Kim, Mario Romero-Ortega, Muthu Wijesundara, Caleb Nothnagle
  • Patent number: 10387106
    Abstract: A media-playback device acquires a heart rate, selects a song with a first tempo, and initiates playback of the song. The song meets a set of qualification criteria and the first tempo is based on the heart rate, such as being equal to or less than the heart rate. The media-playback device also initiates playback of a binaural beat at a first frequency. Over a period of time, the binaural beat's first frequency is changed to a second frequency. Over the period of time, the first tempo can also be changed to a second tempo, where the second tempo is slower than the first tempo.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: August 20, 2019
    Assignee: SPOTIFY AB
    Inventors: Mateo Rando, Tristan Jehan
  • Patent number: 10384063
    Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: stimulation means for electrically stimulating at least one nerve with at least one stimulation pulse; control means connected to the stimulation means for controlling at least one characteristic of the at least one stimulation pulse; and modulating means connected to the control means for modulating the at least one characteristic of the at least one stimulation pulse according to the time of day.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: August 20, 2019
    Assignee: Neurometrix, Inc.
    Inventors: Shai N. Gozani, Xuan Kong
  • Patent number: 10376689
    Abstract: The present disclosure generally relates to extraforaminal electrical stimulation systems and leads for electrical stimulation of the dorsal root and dorsal root ganglion (DRG), minimally invasive implantation methods therefore, and related methods of providing extraforaminal electrical stimulation of the dorsal root and DRG for the treatment of a medical condition. In accordance with certain aspects, the extraforaminal electrical stimulation leads and methods are particularly suited for stimulation of dorsal roots and DRG of the cervical and thoracic spine.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 13, 2019
    Assignee: PACESETTER, INC.
    Inventors: Alexander Kent, William Cusack, Xiaoyi Min, Gene A. Bornzin