Directly Or Indirectly Stimulating Motor Muscles Patents (Class 607/48)
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Patent number: 12649057Abstract: Systems and methods for generating a finite element model (FEM) of current flow in an anatomical human forearm are disclosed. The disclosed FEM may assist in determining optimal stimulation parameters in electrical stimulation systems for achieving movement of paralyzed limbs or enhancement of able limbs. This model will allow users to determine which muscle groups are receiving stimulation under different parameters. Systems and methods which leverage electrical impedance tomography (EIT) for autonomous recalibration following garment donning are also disclosed. The method may comprise performing an EIT measurement across an electrode array of an electrode garment and constructing an anatomical model based on the EIT measurement. Next, one or more alignment variations may be estimated based on an alignment variation model. Finally, the electrode array is adjusted, automatically or manually, to accommodate the alignment variations using an alignment adjustment function.Type: GrantFiled: July 30, 2021Date of Patent: June 9, 2026Assignee: Battelle Memorial InstituteInventors: Sam Colachis, David Friedenberg
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Patent number: 12636494Abstract: A method for controlling a stimulation signal for brain stimulation comprises: transmitting a trigger signal for triggering a stimulation generator to output a high frequency synchronization signal exhibiting periodical modifications; receiving a measurement signal representing brain activity comprising neural oscillations and a response to the high frequency synchronization signal; determining adjustment of a phase of the stimulation signal based on a phase difference between the neural oscillations and the modifications of the high frequency synchronization signal; and transmitting a phase information signal for providing information of an adjusted phase of the stimulation signal to be used by the stimulation generator.Type: GrantFiled: December 5, 2022Date of Patent: May 26, 2026Assignee: STICHTING IMEC NEDERLANDInventors: Ilkka Kosunen, Vojkan Mihajlovic
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Patent number: 12636514Abstract: Respiratory function can be preserved and/or enhanced in patients with a respiratory insufficiency using a photoceutical applied by a photoceutical medical device to at least one primary inspiratory muscle and/or a lung. At least one site on a body of a patient can be selected for delivery of the photoceutical to the muscle(s); and the photoceutical can be applied at the at least one site by the photoceutical medical device for a time period from a first start time to a first end time to treat the at least one primary inspiratory muscle and/or the lung of the patient to preserve and/or enhance the respiratory function. The photoceutical can include a light signal with at least one delivery scheme (e.g., superpulsed, pulsed. and/or continuous) and one or more wavelengths.Type: GrantFiled: October 31, 2022Date of Patent: May 26, 2026Assignee: MEDICAL QUANT USA INC.Inventors: Douglas Johnson, Max Kanarsky, Ernesto Cesar Pinto Leal Junior
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Patent number: 12622588Abstract: A system may include a neuromodulator and a processing system. The neuromodulator may be configured to be programmed with a set of more than one program to deliver neuromodulation. The processing system may be configured to: receive sensed data indicative of activity, motion and/or posture of a patient; analyze the activity, motion and/or posture of the patient; and perform a process, based on the analyzed activity, motion and/or posture, for switching from one program in the set of more than one program to another program from the set of more than one program. The process may include automatically implementing the other program from the set of more than one program or suggesting to switch to the other program from the set of more than one program.Type: GrantFiled: November 16, 2022Date of Patent: May 12, 2026Assignee: Boston Scientific Neuromodulation CorporationInventors: Luca Antonello Annecchino, Matthew Lee McDonald, Que T. Doan, Changfang Zhu, Rosana Esteller
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Patent number: 12622603Abstract: A method of monitoring depth of muscle relaxation of a patient includes applying a series of stimulations to a nerve of a patient and measuring muscle responses thereto. A maximal stimulus current, a supramaximal stimulus current, and/or a submaximal stimulus current are determined based on the muscle responses, wherein the maximal stimulus current is a current at which a maximal muscle response is produced from stimulating the nerve, the supramaximal stimulus current is greater than or equal to the maximal stimulus current, and the submaximal stimulus current is less than the maximal stimulus current. A first set of stimulations are applied to the nerve of the patient. Either the supramaximal stimulus current or the submaximal stimulus current are then selected for a subsequent series of stimulations based on the measured muscle responses to the first series of stimulations, and the subsequent series of stimulations are performed accordingly to monitor the patient's depth of muscle relation.Type: GrantFiled: April 11, 2024Date of Patent: May 12, 2026Assignee: GE Precision Healthcare LLCInventors: Mika Olli Kristian Sarkela, Mari Johanna Partio
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Patent number: 12597516Abstract: The invention relates to the technical field of physiotherapy apparatuses, and discloses a method and system for controlling physiotherapy apparatuses. The method is applied to physiotherapy apparatuses. The physiotherapy apparatuses include a remote controller, a host and electrode sheets. The remote controller is wirelessly connected to the host computer. The remote controller is used to transmit signals to remotely control the host computer. The host computer and the electrode sheets are connected through connecting pieces, the connecting pieces are metal snap buttons, and the host computer is used to receive signals transmitted by the remote controller and generate pulse signals to be transmitted to the electrode sheets. The present invention connects a plurality of hosts through a remote controller, realizes wireless control of multiple hosts by a remote controller, and can use different massage modes for different parts to meet the needs of users for different massage modes.Type: GrantFiled: July 24, 2023Date of Patent: April 7, 2026Inventor: Raymond Hsu
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Patent number: 12589240Abstract: A muscle stimulation system includes an electrical stimulation garment and a stimulation controller. The stimulation controller has a stimulation processor programmed to identify the electrical stimulation garment and execute a treatment protocol associated with the electrical stimulation garment. A method includes determining a type of electrical stimulation garment and selecting a treatment protocol based at least in part on the type of electrical stimulation garment detected.Type: GrantFiled: March 11, 2022Date of Patent: March 31, 2026Assignee: AxioBionics LLCInventor: Philip Muccio
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Patent number: 12569193Abstract: Systems and techniques are disclosed to evaluate a neurostimulation treatment provided from a neurostimulation device, based on freeform text analysis. In an example, a system or device to evaluate a neurostimulation treatment provided from a neurostimulation device is configured to perform operations that: obtain text content, originating from text or voice input of a human patient, which relates to a state of a human patient; identify a state of the human patient from natural language processing of the text content; obtain device data from the neurostimulation device; identify a state of the neurostimulation treatment of the human patient from the device data; associate the identified state of the human patient to the identified state of the neurostimulation treatment; and initiate an action for the neurostimulation treatment, based on the identified state of the human patient that is associated with the identified state of the neurostimulation treatment.Type: GrantFiled: December 6, 2022Date of Patent: March 10, 2026Assignee: Boston Scientific Neuromodulation CorporationInventors: Kyle Harish Srivastava, Benjamin Phillip Hahn, Amarpreet Singh Bains
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Patent number: 12558019Abstract: A balance prosthesis device for an individual including a sensor module configured to obtain a sensor signal indicative of a balance or equilibrium state of the individual, a processing module configured to determine at least one neurostimulation signal based at least in part on the obtained sensor signal, and a transmitter module configured to transmit the determined neurostimulation signal to a neurostimulation device of the individual. The neurostimulation signal is configured to elicit an artificial sensation in a specific sensory cortex area of the individual via directly stimulating afferent sensory axons of the central or peripheral nervous system of the individual targeting sensory neurons of the sensory cortex area not directly associated with vestibulocortical pathways of the individual. The elicited artificial sensation provides a balance indication to the individual in order to support, mimic, substitute or enhance the natural sense of balance of the individual.Type: GrantFiled: April 19, 2021Date of Patent: February 24, 2026Assignee: CEREGATE GmbHInventors: Bálint Várkuti, Saman Hagh-Gooie
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Patent number: 12558533Abstract: A device for functional electrical stimulation (FES), neuromuscular electrical stimulation (NMES), and/or in receiving electromyography (EMG) signals includes a sleeve and electrodes. The sleeve is sized and shaped to be worn on a human arm, and comprises a stretchable fabric The electrodes are secured with the sleeve and positioned to contact skin of the human arm when the sleeve is worn on the human arm. An electronic circuit is configured to operate the electrodes. The electronic circuit includes relays connecting the electrodes with a stimulator for performing FES or NMES, and EMG readout circuitry connecting the electrodes with an EMG amplifier. The relays are closed during FES or NMES to connect the stimulator with the electrodes. The relays are open during EMG readout to isolate the stimulator from the EMG amplifier.Type: GrantFiled: July 30, 2021Date of Patent: February 24, 2026Assignee: BATTELLE MEMORIAL INSTITUTEInventors: Timothy M. Blum, Joshua R. Branch, Samuel Colachis, Amanda I. Noonan, John E. Bartholomew, Nicholas Annetta, Yelena Davis
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Patent number: 12558546Abstract: Systems and methods are directed to influencing organ function by stimulating the dorsal root ganglion. Systems include at least one electrode to deliver electrical stimulation to the dorsal root ganglion to activate afferent nerves innervating at least one organ, and computing apparatus comprising one or more processors operably coupled to the at least one electrode to control the electrical stimulation.Type: GrantFiled: July 22, 2021Date of Patent: February 24, 2026Assignee: Medtronic, Inc.Inventors: Lilian Kornet, Richard Cornelussen, Mirko De Melis, Berthold Stegemann, Jules Hamers
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Patent number: 12558001Abstract: A method for determining a muscle fatigue of a muscle includes the step of electrostimulating the muscle at different frequencies, wherein the electrostimulation includes, at each frequency, a repetition of pulses during a period of time lower than 5 s. The method further includes the steps of determining forces developed by the muscle in response to the electrostimulations of step (i); and determining a muscle fatigue on basis of the determined forces.Type: GrantFiled: June 9, 2021Date of Patent: February 24, 2026Assignee: MYOCENEInventors: Pierre Rigaux, Jean-Yves Mignolet
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Patent number: 12552012Abstract: An exoskeleton is disclosed having a first exoskeleton element, a second exoskeleton element and a pneumatic actuator which is mechanically connected to the first exoskeleton element and the second exoskeleton element. The exoskeleton further comprises a control unit which is arranged to switch, when the first pneumatic actuator is controlled, between a first active support mode and a first passive support mode in which the first pneumatic actuator is not vented to the environment.Type: GrantFiled: July 7, 2020Date of Patent: February 17, 2026Assignee: EXOIQ GmbHInventors: Robert Weidner, Bernward Otten
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Patent number: 12533504Abstract: A portable and wearable hand-grasp neuro-orthosis is configured for use in a home environment to restore volitionally controlled grasp functions for a subject with a cervical spinal cord injury (SCI). The neuro-orthosis may include: a wearable sleeve with electrodes; electronics for operating the wearable sleeve to perform functional electrical stimulation (FES) and electromyography (EMG), the electronics configured for mounting on a wheelchair; and a controller configured for mounting on a wheelchair. The controller controls the electronics to read EMG via the sleeve, decode the read EMG to determine an intent of the user, and operate the electronics to apply FES via the sleeve to implement the intent of the user. The neuro-orthosis may restore hand function. The controller may include a display arranged to be viewed by the subject, for example mounted on an articulated arm attached to the wheelchair.Type: GrantFiled: July 27, 2023Date of Patent: January 27, 2026Assignee: BATTELLE MEMORIAL INSTITUTEInventors: David Friedenberg, Gaurav Sharma, Samuel Colachis, Nicholas Annetta, Amanda Noonan
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Patent number: 12521244Abstract: Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject.Type: GrantFiled: September 11, 2020Date of Patent: January 13, 2026Assignee: The Johns Hopkins UniversityInventors: Chad Gordon, Micah Belzberg, Amir Manbachi
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Patent number: 12515046Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within a patient's ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.Type: GrantFiled: September 30, 2022Date of Patent: January 6, 2026Assignees: Washington University, MUSC Foundation for Research DevelopmentInventors: Eric C. Leuthardt, Peter Brunner, Kara Donovan, Aiko Thompson
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Patent number: 12507905Abstract: Systems and methods are providing for detecting and monitoring thoracic fluid, air-trapping and ventilation assessment in real time, wherein data obtained from a non-invasive electrode patch is analyzed using analysis algorithms for an electrical equivalent model that have been personalized for a patient's physiologic characteristics, medical condition and/or historical medical information using machine learning trained on a dataset representative of a large and diverse patient population. The systems and methods provide a simple, real-time, highly sensitive and specific, non-invasive, bedside solution for fluid level assessment, checking for increased air trapping, and ventilation assessment. The described methods include a variety of use cases for the inventive system and methods.Type: GrantFiled: March 24, 2025Date of Patent: December 30, 2025Assignee: Anusar Inc.Inventors: Sriram Ganesan, Goutam Dutta, Rahul Shukla, Jagdish Chander Suri
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Patent number: 12502120Abstract: A muscle relaxation monitoring apparatus includes: a stimulating circuit that stimulates a nerve of a living body; a signal detecting circuit that detects an electric signal generated by a muscle reacting to the stimulation performed by the stimulating circuit; a reaction time calculating circuit that calculates a reaction time which elapses from the stimulation of the nerve by the stimulating circuit until the electric signal is detected by the signal detecting circuit; and a relaxation degree determining circuit that determines a muscle relaxation degree of the living body based on the length of the reaction time calculated by the reaction time calculating circuit.Type: GrantFiled: October 21, 2020Date of Patent: December 23, 2025Assignees: NIHON KOHDEN CORPORATION, KAWASAKI GAKUEN Educational FoundationInventors: Hiroshi Yoshihara, Shigeyoshi Kitamura, Kazuya Nagase, Shunji Iwata, Shunichi Takagi, Hideki Nakatsuka
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Patent number: 12471786Abstract: A smart watch to detect a presence of an arrhythmia of a user is disclosed. The smart watch comprising: a processing device and a photoplethysmography (“PPG”) sensor operatively coupled to the processing device, an ECG sensor comprising two or more ECG electrodes and operatively coupled to the processing device, a display operatively coupled to the processing device, and a memory, operatively coupled to the processing device. The memory may have instructions stored thereon that, when executed by the processing device, cause the processing device to: receive PPG data from the PPG sensor, receive ECG data from the ECG sensor, detect, based on the PPG data and the ECG data simultaneously, the presence of an arrhythmia, and provide one or more recommendations to the user based on the PPG data and the ECG data.Type: GrantFiled: October 3, 2022Date of Patent: November 18, 2025Assignee: ALIVECOR, INC.Inventors: Ravi Gopalakrishnan, Lev Korzinov, Fei Wang, Euan Thomson, Nupur Srivastava, Omar Dawood, Iman Abuzeid, David E. Albert
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Patent number: 12465760Abstract: A pad having a topcoat layer, an electrode element and a conductive gel element are described. The electrode element is connected to the topcoat layer, and configured to receive an electrical signal from a generator producing an electric signal as a TTField. The conductive gel element is directly connected to the electrode element so as to receive an electrical current from the electrode element. The conductive gel element is configured to be in contact with a patient's skin. The electrode element and the conductive gel element define kirigami-like cuts, the kirigrami-like cuts being a predetermined pattern of cuts resulting in the electrode element, the flexible polymer layer, and the conductive gel element forming a three-dimensional shape conforming to a predetermined portion of a patient's body.Type: GrantFiled: November 16, 2023Date of Patent: November 11, 2025Assignee: Novocure GmbHInventor: Richard Deslauriers
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Patent number: 12458267Abstract: A muscle fatigue determination method including a step of electrostimulating a muscle at an electric charge at different frequencies. The electric charge is determined recursively in order to generate reliable and accurate forces of the muscle in response to the electrostimulation. The method further includes the steps of determining these forces and a muscle fatigue based on them.Type: GrantFiled: December 30, 2021Date of Patent: November 4, 2025Assignee: MYOCENEInventors: Pierre Rigaux, Jean-Yves Mignolet
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Patent number: 12458803Abstract: Disclosed herein are devices and methods used with neurostimulation therapy for spinal cord injury. More particularly, embodiments of the present invention relate to a sync pulse detector and methods for synchronizing signals from an implanted neurostimulator with measured physiological responses and other data.Type: GrantFiled: February 11, 2022Date of Patent: November 4, 2025Assignee: University of Louisville Research Foundation, Inc.Inventors: Susan J. Harkema, Yangsheng Chen, Douglas J. Jackson, Manikandan Ravi, Claudia Angeli
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Patent number: 12458794Abstract: An electrostimulation method of at least one muscle group responsible for performing a complex movement includes associating to each of the muscles of the at least one muscle group an electrostimulation channel provided with at least one respective electrode. Each electrostimulation channel is suitable to transmit to the respective muscle bipolar electrical pulses in sequence. For all the electrostimulation channels, a same cycle time defining a repeatable period of stimulation is determined, in which, within the stimulation period, each channel performs its own stimulation sequence. Each stimulation period is sub-divided into two half-periods of equal duration. Each half-period is sub-divided into sub-intervals of the same duration. At least one of the sub-intervals is a stimulation sub-interval wherein a basic sequence of pulses including one or more pulse packets is performed, each pulse packet having a predetermined sequence of individual bipolar electric pulses.Type: GrantFiled: November 6, 2023Date of Patent: November 4, 2025Assignee: VIKTOR S.R.L.Inventor: Viktor Terekhov
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Patent number: 12427327Abstract: An implantable leadless pacemaker configured to provide antibradycardia pacing of a human or animal heart, comprising: an electrical energy source, a sensor configured to sense intracardiac potentials of the heart, a pulse generator configured to generate electrical pacing pulses, a control unit for controlling the pulse generator, wherein the control unit is configured to inhibit generation of an electrical pacing pulse when an intracardiac potential is sensed, wherein the control unit is further configured to permanently switch off the pulse generator after passing of a predetermined timespan and/or after a pre-defined event detected by the pacemaker, an electrode pole for electrical stimulation and sensing intracardiac potentials, at least one fastening element for fastening the pacemaker to heart tissue, wherein the implantable leadless pacemaker is adapted such that a lifetime of the implantable leadless pacemaker is smaller than one year, particularly smaller than one month, particularly smaller than twType: GrantFiled: January 21, 2021Date of Patent: September 30, 2025Assignee: BIOTRONIK SE & Co. KGInventors: Thomas Doerr, Georg Nollert
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Patent number: 12415066Abstract: A neural stimulator system which generates stimulation from an implantable stimulator circuit which generates stimulation outputs which mimic biological signals. The user/operator can select stimulation generated from recorded waveforms, or by selecting the characteristics for generating stimulation based on randomized inter-pulse-intervals (IPI). A control unit controls the operation of the implantable stimulator circuit, and receives sets of stimulation parameters based on user input from a user input device executing application specific programming.Type: GrantFiled: July 19, 2022Date of Patent: September 16, 2025Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Wentai Liu, Stanislav Culaclii, Po-Min Wang, Yi-Kai Lo
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Patent number: 12387832Abstract: Disclosed is a user aware microcurrent therapy device with improved reliability of microcurrent therapy so that a user can determine an operation of the microcurrent therapy device.Type: GrantFiled: August 18, 2021Date of Patent: August 12, 2025Assignee: Lee Sol Co., Ltd.Inventors: Moonsoo Kim, Seung Woo Lee
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Patent number: 12343540Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.Type: GrantFiled: June 8, 2022Date of Patent: July 1, 2025Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Theoden I. Netoff, Andrew Lamperski, David Darrow, Tyler Lekang, Zixi Zhao
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Systems and methods for reducing neurostimulation electrode configuration and parameter search space
Patent number: 12337183Abstract: Systems and methods for reducing neurostimulation electrode configuration and parameter search space and controlling electrostimulation are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device receives electrode position information relative to an anatomical region of interest or physiological signals respectively sensed by the plurality of electrodes, and identifies a search space of electrode configurations and parameter values for the lead with respect to the neural target. The programing device can determine a target stimulation setting based on a clinical response to electrostimulation delivered using electrodes and stimulation parameter values from the identified search space, and generate a control signal to the control the implantable stimulator to deliver electrostimulation in accordance with the target stimulation setting.Type: GrantFiled: April 26, 2022Date of Patent: June 24, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Lisa Denise Moore, Mahsa Malekmohammadi -
Patent number: 12285608Abstract: A neuromodulation targeting system includes a GUI that facilitates selection of one or more neuromodulation target regions. The GUI provides an interactive display representing anatomy of a patient with user-selectable portions corresponding to a plurality of predefined anatomical regions associated with distinct localized clinical effects of neuromodulation. The system further includes a targeting selector engine that is responsive to user selection of a first portion of the interactive display by configuring delivery of neuromodulation therapy to a first target region to produce a first localized clinical effect in the patient at a location corresponding to the first portion of the display, upon administration of the neuromodulation therapy to the patient.Type: GrantFiled: October 7, 2020Date of Patent: April 29, 2025Assignee: Boston Scientific Neuromodulation CorporationInventors: Tianhe Zhang, Bradley Lawrence Hershey, Michael A. Moffitt
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Patent number: 12285241Abstract: Systems and methods for monitoring heart failure (HF) status in a patient are discussed. An exemplary system includes a gait analyzer circuit than can receive gait or balance information, and generate a gait feature such as gait speed or a gait pattern. The system includes a HF detector circuit that can detect patient HF status, or to predict patient risk of a future worsening heart failure (WHF) event, using the gait feature. In some examples, the system may trigger sensing physiologic information according to the detected gait, and detect patient HF status using the sensed physiologic information. The system can initiate or adjust a heart failure therapy according to the HF status or the WHF risk.Type: GrantFiled: December 2, 2019Date of Patent: April 29, 2025Assignee: Cardiac Pacemakers, Inc.Inventors: Gezheng Wen, Bin Mi, Qi An, Pramodsingh Hirasingh Thakur
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Patent number: 12274878Abstract: A medical system for treating incontinence includes an implantable medical device (IMD) implantable proximate to a tibial nerve of a patient comprising therapy delivery circuitry configured to provide electrical stimulation therapy proximate the tibial nerve of the patient for treating incontinence, and processing circuitry configured to: during an implant period, determine a set of stimulation parameters to control the therapy delivery circuitry, during an induction period after the implant period, initiate electrical stimulation therapy according to the set of stimulation parameters, during a first maintenance period, determine an adjustment to the set of stimulation parameters as first maintenance period stimulation parameters to reduce the electrical stimulation therapy from the induction period, and during a second maintenance period, determine an adjustment to the set of stimulation parameters as second maintenance period stimulation parameters to reduce the electrical stimulation therapy from the firstType: GrantFiled: November 4, 2021Date of Patent: April 15, 2025Assignee: Medtronic, Inc.Inventors: Sarah J. Offutt, Nicholas Reid Singer, Katie C. Bittner
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Patent number: 12251225Abstract: A non-invasive diagnostic assembly that includes an interface configured for connection to a diagnostic monitoring device; a plurality of electrodes configured for adhesion to a patient's skin at respective locations and electrically connected to the interface; and at least one adjustable connection segment having a concertina/accordion/ripple-shaped configuration connecting at least two electrodes of the plurality of electrodes.Type: GrantFiled: October 12, 2020Date of Patent: March 18, 2025Assignee: Xavant Technologies (Pty) Ltd.Inventors: Corlius Fourie Birkill, Roche Janse Van Rensburg, Barend Jacques Swart, Dawid Gideon Le Roux Van Niekerk, Florian Martin Lipp, Johan Amey Sieling
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Patent number: 12248629Abstract: Techniques for static and dynamic input multiplexing for high-density neural signal recording are disclosed herein. A multiplexer can receive a first set of neural signals via inputs. A subset of the first set of neural signals above a threshold can be determined. A group of the inputs corresponding to the subset of the first set of neural signals can be determined. Operation of the multiplexer can be modified to block inputs not in the identified group of the inputs. A second set of neural signals can be received into the multiplexer via the group of the inputs. The second set of neural signals can be transmitted to a plurality of channels of an amplifier while blocking inputs not in the identified group of the inputs. The second set of neural signals can be amplified using the amplifier. The amplified second set of neural signals can be transmitted for further processing.Type: GrantFiled: February 28, 2022Date of Patent: March 11, 2025Assignee: Neuralink Corp.Inventors: Do Yeon Yoon, Dongjin Seo, SungWon Chung
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Patent number: 12201833Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.Type: GrantFiled: May 2, 2023Date of Patent: January 21, 2025Assignee: The Regents of the University of CaliforniaInventors: Victor Reggie Edgerton, Yury P. Gerasimenko, Parag Gad, Nicholas A. Terrafranca
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Patent number: 12186561Abstract: Methods and systems for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system are disclosed. The disclosed systems and methods use algorithms to identify patient-specific metrics to use as feedback variables for optimizing stimulation parameters for a patient. The patient-specific metric(s) are determined by ranking a plurality of clinical indicators for the patient with and without the presence of a medical intervention to determine which clinical indicators respond most strongly to the medical intervention. The clinical indicators that respond most strongly can be used as the patient-specific metric for optimizing stimulation, or a composite patient-specific metric may be derived as a mathematical combination of a plurality of clinical indicators that respond well to the intervention.Type: GrantFiled: June 7, 2023Date of Patent: January 7, 2025Assignee: Boston Scientific Neuromodulation CorporationInventor: León M. Juárez Paz
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Patent number: 12178746Abstract: Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.Type: GrantFiled: May 1, 2023Date of Patent: December 31, 2024Assignee: Pacira CryoTech, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Patent number: 12178606Abstract: Systems, devices and methods are provided for neuromonitoring, particularly neuromonitoring to reduce the risks of contacting or damaging nerves or causing patient discomfort during and after surgical procedures, including spinal surgeries. The neuromonitoring procedures include monitoring for the presence of or damage to sensory nerves, and optionally includes additional monitoring for motor nerves. In some systems, including systems that monitor for both sensory and motor nerves, components of the monitoring systems (e.g., stimulating electrodes and response sensors), may be combined with one or more surgical instruments. The systems, devices, and methods provide for pre-surgical assessment of neural anatomy and surgical planning, intraoperative monitoring of nerve condition, and post-operative assessment of nerve position and health.Type: GrantFiled: May 5, 2021Date of Patent: December 31, 2024Assignee: Cadwell Laboratories, Inc.Inventors: Justin Scott, John Cadwell
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Patent number: 12168128Abstract: Systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like. The system comprises a stimulator configured for wireless coupling to a mobile device and comprising a signal generator that generates an electrical impulse and an energy source. The stimulator includes a contact surface configured to contact an outer skin surface of a head of a patient and a user interface for selecting a therapy regimen. The stimulator transmits the electrical impulse transcutaneously through the outer skin surface to a nerve at a target region of the head, wherein the electrical impulse is sufficient to modulate the nerve and modify the medical condition. The system further comprises a software program downloadable onto the mobile device and configured to communicate with the stimulator.Type: GrantFiled: November 1, 2023Date of Patent: December 17, 2024Assignee: ELECTROCORE, INC.Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
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Patent number: 12167918Abstract: A transcutaneous electrical stimulation system is provided that can include a number of features. In one implementation, the system can include a plurality of electrodes configured to be in contact with a skin surface of a patient. The system can further include a flexible hub electrically connected to the electrodes and configured to be in contact with the patient. A bend sensor can be disposed in the hub and configured to measure a curvature of the hub. The system can include a signal processing device electrically coupled to the plurality of electrodes and the bend sensor, the signal processing device being configured to change stimulation settings of the plurality of electrodes based on the curvature of the hub. In some implementations, the system can include a multi-channel stimulator. Methods of use are also provided.Type: GrantFiled: September 28, 2020Date of Patent: December 17, 2024Assignee: NICHE BIOMEDICAL, INC.Inventors: Yi-Kai Lo, Rachel Yung, Po-Min Wang, Alexander Barnes Baldwin, Chia-Hung Ni
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Patent number: 12168133Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.Type: GrantFiled: April 10, 2023Date of Patent: December 17, 2024Assignee: Medtronic, Inc.Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker
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Patent number: 12161861Abstract: Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.Type: GrantFiled: November 21, 2022Date of Patent: December 10, 2024Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Niloy Bhadra, Kevin L. Kilgore, Narendra Bhadra, Jesse Wainright, Tina Vrabec, Manfred Franke
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Patent number: 12161864Abstract: A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns.Type: GrantFiled: December 20, 2023Date of Patent: December 10, 2024Assignee: BATTELLE MEMORIAL INSTITUTEInventors: David A. Friedenberg, Po-Hsu Chen, Samuel Colachis, Nicholas Annetta, Douglas E. Boyd, Collin Dunlap, Ian W. Baumgart, Herbert S. Bresler
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Patent number: 12144981Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.Type: GrantFiled: June 8, 2023Date of Patent: November 19, 2024Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Dustin J. Tyler, Daniel Tan, Matthew Schiefer
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Patent number: 12102819Abstract: The present disclosure relates to an EMS method using EMS electrode pads. Each electrode may be provided to correspond to the shape and size of the divided area according to the virtual line. The EMS method using the same according to the present invention may minimize the edge current effect by the shape of the electrode to which electric energy is applied. In addition, energy transfer efficiency may be improved by capacitive coupling between the electrode and the skin. In addition, due to the coating of the electrode, a rate of contact with an affected part may be increased so that current may be applied evenly to each part.Type: GrantFiled: September 18, 2023Date of Patent: October 1, 2024Assignee: LUTRONIC CORPORATIONInventors: Kwang Chon Ko, James Bartholomeusz
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Patent number: 12097365Abstract: Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.Type: GrantFiled: October 14, 2022Date of Patent: September 24, 2024Assignee: Mainstay Medical LimitedInventors: Peter Andrew Crosby, Dan Sachs, Prashant Brijmohansingh Rawat, Jason Alan Shiroff, Johannes Petrus Heemels
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Patent number: 12090321Abstract: Example systems for positioning an implantable electrode may include a stimulation circuitry, a sensing circuitry, and processing circuitry. The stimulation circuitry may generate electrical stimulation deliverable to a patient. The sensing circuitry may sense electromyographic (EMG) responses. The processing circuitry may control the stimulation circuitry to deliver the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions. The processing circuitry may sense, via the sensing circuitry, electromyographic (EMG) responses to the electrical stimulation. The processing circuitry may score one or more of the different positions for chronic implantation of at least one implantable electrode. The scoring may be based on a stimulation metric level greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses, and a level of the at least some of the sensed EMG responses.Type: GrantFiled: September 20, 2021Date of Patent: September 17, 2024Assignee: Medtronic, Inc.Inventors: Xin Su, David A. Dinsmoor, Jason E. Agran
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Patent number: 12076558Abstract: A method and system for facilitating stimulating of muscles of users are provided. Further, the method may include a step of receiving muscle data from sensors, analyzing the muscle data, generating first muscle activity data of the muscles of first users based on the analyzing of the muscle data, receiving first biological metrics of the first users from first devices, receiving second biological metrics of second users from second devices, analyzing the first muscle activity data, the first biological metrics, and the second biological metrics, transforming the first muscle activities into second muscle activities of the muscles of the second users, generating muscle activation commands for the muscle activation of the muscles of the second users, transmitting the muscle activation commands to muscle stimulators disposable on body parts of the second users, and storing the first muscle activity data and the muscle activation commands.Type: GrantFiled: September 22, 2021Date of Patent: September 3, 2024Inventor: Gary Thomas Baker, Jr.
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Patent number: 12076557Abstract: A treatment assembly can have an inner layer having an inner surface and an outer surface and defining a plurality of openings extending therethrough. The treatment assembly can further comprise a plurality of plates, each plate being at least partially received within a respective opening of the plurality of openings of the inner layer. The treatment assembly can further comprise treatment circuitry comprising a cable having a plurality of electrical leads and a plurality of lead ends, each electrical lead being electrically connected to a respective lead end of the plurality of lead ends. A cover layer can be attached to the outer surface of the inner layer and overlie the plurality of lead ends of the cable. The plurality of lead ends can be in contact with respective plates of the plurality of plates to define a plurality of electrodes.Type: GrantFiled: September 7, 2022Date of Patent: September 3, 2024Assignee: NOVOCURE GMBHInventors: Mijal Munster, Yoram Wasserman, Michael Shtotland, Shiri Davidi, Roni Blat, Golan Bar Tal, Moshe Giladi, Michael Krinitsky, Shalom Strauss
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Patent number: RE50815Abstract: The present disclosure relates to methods and systems for providing virtual feedback of a neural pattern to create a neural pathway corresponding to an action of an affected limb of a brain injury patient. Embodiments provide for detecting a neural pattern and determining a target action associated with the detected neural pattern. A virtual feedback is generated that includes a virtual action to be performed in a virtual representation of the affected limb. In embodiments, the brain injury may prevent the affected limb from performing the target action. The virtual representation of the affected limb is superimposed over a real-world presence of the affected limb such that the virtual representation is presented to the patient in lieu of the real-world presence, and the virtual action is performed in the virtual representation, such that the virtual action is presented to the patient in lieu of the target action in the real-world.Type: GrantFiled: April 3, 2024Date of Patent: March 10, 2026Assignee: Neuromersive, Inc.Inventor: Veena Somareddy
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Patent number: RE50905Abstract: Methods and systems for monitoring, preventing and/or treating upper airway disorders such as apnea, dysphagia, reflux and/or snoring are described. The methods and systems monitor the upper airway disorders by processing one or more neural signals obtained from one or more upper airway afferents. Upper airway disorders are prevented and/or treated by delivering one or more stimulations to one or more reflex-related afferents, efferents, muscles, and sensory receptors to manipulate the threshold and/or trigger an upper airway reflex including, but not limited to a swallow reflex and/or a negative-pressure reflex.Type: GrantFiled: November 30, 2021Date of Patent: June 2, 2026Assignee: MED-EL Elektromedizinische Geraete GmbHInventor: Willard Wilson