Directly Or Indirectly Stimulating Motor Muscles Patents (Class 607/48)
  • Patent number: 11607551
    Abstract: A neurostimulation system includes a programming control circuit and a user interface. The programming control circuit may be configured to generate a plurality of stimulation parameters controlling delivery of neurostimulation pulses according to one or more neurostimulation programs each specifying a pattern of the neurostimulation pulses. The user interface includes a display screen, a user input device, and a neurostimulation program circuit. The neurostimulation program circuit may be configured to allow for construction of one or more pulse trains (PTs) and one or more train groupings (TGs) of the one or more neurostimulation programs, and to allow for scheduling of delivery of the one or more neurostimulation programs, using the display screen and the user input device. Each PT includes one or more pulse blocks each including a plurality of pulses of the neurostimulation pulses. Each TG includes one or more PTs.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: March 21, 2023
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: David Ernest Wechter
  • Patent number: 11609633
    Abstract: Various embodiments of an apparatus, methods, systems and computer program products described herein are directed to an Analytics Engine that receives one more signal files that include neural signal data of a user based on voltages detected by one or more electrodes on a set of headphones worn by a user. The Analytics Engine preprocesses the data, extracts features from the received data, and feeds the extracted features into one or more machine learning models to generate determined output that corresponds to at least one of a current mental state of the user and a type of facial gesture performed by the user. The Analytics Engine sends the determined output to a computing device to perform an action based on the determined output.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: March 21, 2023
    Assignee: Neurable, Inc.
    Inventors: Ramses Eduardo Alcaide, David Stanley, Dereck Padden, James Hamet, Adam Molnar, Jamie Alders, Jegan Candassamy, Arjun Daniel Srinivas
  • Patent number: 11607549
    Abstract: Passive tissue biasing circuitry in an Implantable Pulse Generator (IPG) is disclosed to facilitate the sensing of neural responses by holding the voltage of the tissue to a common mode voltage (Vcm). The IPG's conductive case electrode, or any other electrode, is passively biased to Vcm using a capacitor, as opposed to actively driving such electrode to a prescribed voltage using a voltage source. Once Vcm is established, voltages accompanying the production of stimulation pulses will be referenced to Vcm, which eases neural response sensing. An amplifier can be used to set a virtual reference voltage and to limit the amount of current that flows to the case during the production of Vcm. Circuitry can be used to monitor the virtual reference voltage to enable sensing neural responses, and to set a compliance voltage for the current generation circuitry.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: March 21, 2023
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Goran N. Marnfeldt
  • Patent number: 11596792
    Abstract: A system, method, and apparatus for treating a medical condition by applying transcutaneous electrical stimulation to a target peripheral nerve of a subject. Electrical stimulation is applied to the peripheral nerve via a stimulation electrode pattern under closed-loop control in which EMG responses are monitored and used to adjust stimulation parameters. In response to detecting an unacceptable recording, electrical stimulation is applied to the peripheral nerve under open-loop control.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: March 7, 2023
    Assignee: AVATION MEDICAL, INC.
    Inventors: Alexandru Campean, Jeff A. Weisgarber, Mingming Zhang
  • Patent number: 11590340
    Abstract: Systems, methods, and devices are provided herein providing electrical muscle stimulation (EMS). In some instances, an EMS device may be provided. The EMS device may be compact, light, and unobtrusive such that it can be used by a person going about his or her daily activities. In some instances, the EMS device may comprise additional sensors for increased functionality and may be capable of interacting with additional devices or platforms to provide a full-fledged EMS device capability.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: February 28, 2023
    Assignee: Therabody, Inc.
    Inventors: Alexey Pisarev, Vladimir Pisarev
  • Patent number: 11590352
    Abstract: Systems and methods for treating a patient's pain using ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods are disclosed. A representative method for treating a patient includes positioning an implantable signal delivery device proximate to a target location at or near the patient's spinal cord, and delivering an electrical therapy signal to the target location via the implantable signal delivery device, wherein the electrical therapy signal has a frequency in a frequency range of from about 1 kHz to about 100 kHz, and wherein the frequency is increased or decreased from a first value to a second value during delivery.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: February 28, 2023
    Assignee: Nevro Corp.
    Inventors: Dongchul Lee, Kerry Bradley, Kwan Yeop Lee
  • Patent number: 11559250
    Abstract: The present invention relates to a movement disorder monitor with high sensitivity, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately and repeatably quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and/or electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides substantially real-time remote access to data by the clinician or physician.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: January 24, 2023
    Assignee: Great Lakes NeuroTechnologies Inc.
    Inventors: Joseph P. Giuffrida, Dustin A. Heldman
  • Patent number: 11554265
    Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: January 17, 2023
    Assignee: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
  • Patent number: 11547480
    Abstract: The invention relates to a system (1) for stimulating renal nerves of a renal artery of a subject (3). The system comprises a stimulation device (12, 17, 28) for stimulating the renal nerves, a measuring unit (20) for measuring the blood pressure and/or the heart rate of the subject at at least two times, wherein at least one of these times is during or after the stimulation of the renal nerves, and a subject suitability determination unit (14) for determining whether the subject is suitable for a renal sympathetic denervation procedure based on the measured blood pressure and/or the measured heart rate. The invention allows therefore for a preselection of subjects which are suitable for a renal sympathetic denervation procedure.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: January 10, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Steffen Weiss
  • Patent number: 11541229
    Abstract: An apparatus of muscle treatment may have a plurality of treatment modes and may generate a specific motion of a human body simultaneously or with an interval for muscles anatomically distinguished and related to each other, thereby being able to simultaneously strength the muscles related to each other. Since muscles are treated in accordance with a transmitting pattern of RF energy enabling composite motions of a human body, thereby being able to increase the treatment effect.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: January 3, 2023
    Assignee: LUTRONIC CORPORATION
    Inventors: Kwang Chon Ko, James Bartholomeusz
  • Patent number: 11541235
    Abstract: Device/system that provides pain relief by delivering stimulation that neither generates action potentials nor completely blocks neural transmission (in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve) to alter the frequency of physiologically generated neural transmission.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 3, 2023
    Assignee: SPR THERAPEUTICS, INC.
    Inventors: Joseph W. Boggs, Amorn Wongsarnpigoon, Matthew G. deBock, Nathan Crosby
  • Patent number: 11534605
    Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: December 27, 2022
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Chad E. Bouton, Gaurav Sharma, Andrew Sweeney, Amy M. Heintz, Stephanie Kute, Nicholas Annetta, Thomas D. Haubert, Steven M. Risser, Jeffrey Friend, John Bartholomew, Rachel Thurston, Alexander C. Morrow, George Brand, Jeffrey Ellis, Matthew Mowrer, Raymond Zaborski
  • Patent number: 11529518
    Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: December 20, 2022
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Paul H. Stypulkowski, Timothy J. Denison, Scott R. Stanslaski
  • Patent number: 11524159
    Abstract: A control system for a movement reconstruction and/or restoration system for a patient, comprising a sampling module configured and arranged to sample signals describing directly and/or indirectly motion at a sampling rate of at least 50 Hz; at least one stimulation system configured and arranged to provide stimulation for movement reconstruction and/or restoration to the patient; a prediction module configured and arranged to provide a prediction of at least a next movement, especially movement stage and/or sequence, to reduce latency and to synchronize stimulation to the movement phase, wherein the control system further comprises at least one controller, the controller being configured and arranged to provide stimulation control signals to the stimulation system on the basis of the information obtained by the sampling module and the prediction provided by the prediction module.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: December 13, 2022
    Assignee: Onward Medical N.V.
    Inventors: Miroslav Caban, Niek Borgers, Urs Keller, Joachim von Zitzewitz, Jurriaan Bakker, Vincent Delattre
  • Patent number: 11510603
    Abstract: Devices and methods for stimulation and recording of muscle responses for determining degree of neuromuscular blockade, particularly relevant to elicitation of such responses in those under the influence of anesthesia. A system for estimating the degree of neuromuscular blockade includes at least one stimulating electrode, at least one recording electrode, a pulse generator for providing stimulation to a nerve through the stimulating electrode, and a computing device configured to: apply stimuli to the nerve according to a stimulation protocol, wherein the stimulation protocol provides a plurality of stimulation sequences that vary in frequency of pulses in the stimulation sequence, frequency of the stimulation sequences, number of pulses in the stimulation sequence, or all of the above; measure, by the recording electrode, electrical responses of a muscle; and estimate the degree of neuromuscular blockade based on changes in the electrical responses of the muscle during a stimulation sequence.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: November 29, 2022
    Assignee: SafeOp Surgical, Inc.
    Inventors: Robert Snow, Richard O'Brien
  • Patent number: 11510628
    Abstract: Artifacts due to delivery of an electrical signal (e.g., for neural stimulation or nerve block) can be eliminated from neural recordings. An activating stimulus (AS) can be applied by at least one neural electrode located at a first position within a body or a preparation proximal to a neural structure. The AS includes an electrical waveform configured to affect (e.g., stimulate or block) conduction in the neural structure. A counter stimulus (CS) can be applied by at least one electrode located at a second position within the body or the preparation remote from the neural structure. The CS includes an electrical waveform configured with a timing parameter and an amplitude parameter selected based on a feature of the AS. Artifacts due to the AS can be blocked by the CS during the neural recordings.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 29, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Niloy Bhadra, Kevin L. Kilgore, Thomas Eggers
  • Patent number: 11504526
    Abstract: An electrical stimulation system includes at least one electrical stimulation lead, each of the at least one electrical stimulation lead including a plurality of stimulation electrodes; and a processor coupled to the lead and configured to perform actions, including: directing delivery of at least one electrical pulse through at least one of the stimulation electrodes of the at least one electrical stimulation lead to tissue of a patient; and directing discrete or intermittent measurement of an electrical characteristic of the tissue using at least one of the stimulation electrodes of the at least one electrical stimulation lead during, and after, delivery of the at least one electrical pulse to the tissue of the patient.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: November 22, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Changfang Zhu
  • Patent number: 11504531
    Abstract: A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: November 22, 2022
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: David A. Friedenberg, Po-Hsu Chen, Samuel Colachis, Nicholas Annetta, Douglas E. Boyd, Collin Dunlap, Ian W. Baumgart, Herbert S. Bresler
  • Patent number: 11497452
    Abstract: The present disclosure describes a system, method and software applications for predicting the KAM of a subject for a plurality of gait cycles of a subject. At least one sensor attachable adjacent to the ankle of at least one leg of the subject provides accelerometer and gyroscopic data for the plurality of gait cycles. A processing means receives subject parameters and accelerometer and gyroscopic data from the at least one sensor for evaluation by a neural network of predicted KAM values for the plurality of gait cycles of the subject. The neural network is configured via determining KAM values for each of the plurality of subjects from measurements during a plurality of gait cycles and other parameters.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 15, 2022
    Assignee: The Hong Kong Polytechnic University
    Inventors: Tsz Hei Cheung, Ho Man Chan, Kevin Ki Wai Ho, Zoe Yau Shan Chan, Hanwen Zhang, Man Fung Lam, Chao Wang, Sizhong Wang, Shuotong Wang, Xiaoyu Wei, Akash Malhotra, Chun Kwan Ching
  • Patent number: 11491334
    Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: November 8, 2022
    Assignee: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
  • Patent number: 11471686
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: October 18, 2022
    Assignee: Leonhardt Ventures LLC
    Inventor: Howard J. Leonhardt
  • Patent number: 11458314
    Abstract: A method for configuring an electroanalgesia and electrotherapy apparatus using wireless control, with multiple stimulators, particularly used in the segment of pain control and aid in postoperative tissue repair and reduction of measures and body weight. According to the embodiments, a user with electrodes generically distributed simultaneously in several parts of the body, where at the pain site the frequency is from 80 Hz to 300 Hz or 1000 Hz and then to a range of 15 Hz to 35 Hz or among 0.5 Hz and 10 Hz on that electrode, and at distant points, for example, in upper or lower limbs the frequency is from 0.5 Hz to 10 Hz and, so the person can be submitted to this analgesia procedure, according to the pre-determined frequencies, pulse width and pulse form already pre-defined.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 4, 2022
    Inventor: Jeronimo Manço De Oliveira Neto
  • Patent number: 11458310
    Abstract: An electrical stimulation indoor bike includes a stationary bicycle; an electrical stimulation unit connected to the stationary bicycle either with wire or without wire, and including an electrode pad for applying electrical stimulation to a user's body; and a control unit to control electrical stimulation of the electrical stimulation unit in accordance with an exercise mode of the stationary bicycle. By the electrical stimulation indoor bike, a variety of electrical stimulation according to pedal movement is applied to a body through an indoor bike connected with a low-frequency stimulator, thereby maximizing exercise effect.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 4, 2022
    Assignee: Y & J BIO CO., LTD.
    Inventors: Young Sam Chun, Hyoung Tae Kim
  • Patent number: 11446497
    Abstract: The occurrence of negative consequences (e.g., painful tetanic muscle contractions) associated with the onset response associated with kilohertz frequency alternating current (KHFAC) electrical nerve block can be reduced by fatiguing a muscle (through depletion of neurotransmitters at the neuromuscular junction, within a second) before applying KHFAC electrical nerve block to a nerve associated with the muscle. The nerve can first be stimulated with an electrical signal for a first time period to fatigue the muscle. Then, immediately following the first time period (while the muscle is fatigued), a blocking electrical signal (e.g., a kilohertz frequency alternating current waveform) can be applied to the nerve to create a localized nerve block.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: September 20, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Niloy Bhadra, Thomas Eggers, Kevin L. Kilgore
  • Patent number: 11439816
    Abstract: A treatment assembly can have an inner layer having an inner surface and an outer surface and defining a plurality of openings extending therethrough. The treatment assembly can further comprise a plurality of plates, each plate being at least partially received within a respective opening of the plurality of openings of the inner layer. The treatment assembly can further comprise treatment circuitry comprising a cable having a plurality of electrical leads and a plurality of lead ends, each electrical lead being electrically connected to a respective lead end of the plurality of lead ends. A cover layer can be attached to the outer surface of the inner layer and overlie the plurality of lead ends of the cable. The plurality of lead ends can be in contact with respective plates of the plurality of plates to define a plurality of electrodes.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: September 13, 2022
    Assignee: NOVOCURE GMBH
    Inventors: Michal Munster, Yoram Wasserman, Michael Shtotland, Shiri Davidi, Roni Blat, Golan Bar Tal, Moshe Giladi, Michael Krinitsky, Shalom Strauss
  • Patent number: 11432871
    Abstract: The present disclosure provides electroporation systems and methods of preconditioning tissue for electroporation therapy. An electroporation generator includes an electroporation circuit, a preconditioning circuit, and a controller. The electroporation circuit is configured to be coupled to a catheter for delivering the electroporation therapy to target tissue of the patient. The electroporation circuit is further configured to transmit an electroporation signal through the catheter. The preconditioning circuit is configured to be coupled to a preconditioning electrode for stimulating skeletal muscle tissue of the patient. The preconditioning circuit is further configured to transmit a preconditioning signal to the preconditioning electrode.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: September 6, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Jeff Schweitzer, Gregory K. Olson
  • Patent number: 11426587
    Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: August 30, 2022
    Assignee: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
  • Patent number: 11430564
    Abstract: A patient's healthcare experience may be enhanced utilizing a system that automatically recognizes the patient based on one or more images of the patient and generates personalized medical assistance information for the patient based on electronic medical records stored for the patient. Such electronic medical records may comprise imagery data and/or non-imagery associated with a medical procedure performed or to be performed for the patient. As such, the imagery and/or non-imagery data may be incorporated into the personalized medical assistance information to provide positioning and/or other types of diagnostic or treatment guidance to the patient or a service provider.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: August 30, 2022
    Assignee: SHANGHAI UNITED IMAGING INTELLIGENCE CO., LTD.
    Inventors: Srikrishna Karanam, Ziyan Wu
  • Patent number: 11426580
    Abstract: Examples of the present disclosure are related to devices in the field of transcutaneous electrical nerve stimulation and neuromuscular electrical stimulation. More specifically, embodiments are related to devices that are configured to automatically detect the stimulation intensity range and the motor point to generate a high efficiency, low intensity electrical stimulation treatment.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 30, 2022
    Assignee: HEALTH DISCOVERY LABS LLC
    Inventors: Oussama Hassan, Alaa Hassan
  • Patent number: 11420064
    Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: August 23, 2022
    Assignee: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
  • Patent number: 11420050
    Abstract: Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. The controller is adapted to receive a volitional electrical signal generated by the human that is manifest below the lesion that causes the clinical paralysis. The controller uses at least the volitional electrical signal to generate a control signal that is output back to a plant to change the state of the plant, which in one aspect is one or more of the user's paralyzed muscles to achieve a functional result or to devices in the environment around the user that are adapted to receive commands from the controller.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 23, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Christa Wheeler Moss, Paul Hunter Peckham
  • Patent number: 11400289
    Abstract: Apparatus and methods are described for use with electrophysiological signal detecting electrodes, and a transcranial magnetic stimulation device. A computer processor drives the transcranial stimulation device to apply one or more pulses of transcranial magnetic stimulation to a subject. Within a given time period of applying one of the one or more pulses of transcranial magnetic stimulation to the subject, the computer processor detects an electrophysiological signal of the subject, using the electrophysiological signal detecting electrodes. At least partially in response thereto, the computer processor predicts an outcome of treating the subject for a neuropsychiatric condition, using a given therapy, and generates an output on an output device in response to the predicted outcome. Other applications are also described.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: August 2, 2022
    Assignees: BRAINSWAY LTD., ELMINDA LTD., B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.
    Inventors: Uri Alyagon, Abraham Zangen, Gaby S. Pell, Yiftach Roth, Ronen Segal, Amir Geva, Ziv Peremen, Boaz Sadeh, Revital Shani-Hershkovich, Dror Haor
  • Patent number: 11402904
    Abstract: Systems and methods for providing enhanced surface electrical neurostimulation and haptic feedback to a user within a simulation environment are provided. Enhanced surface electrical neurostimulation (eSENS) platforms are able to elicit distally referred tactile percepts while avoiding large charge densities as a method to deliver intuitive haptic feedback during functional tasks.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: August 2, 2022
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Ranu Jung, Andres E. Pena Serrada
  • Patent number: 11399727
    Abstract: A method for evaluating heart function, comprising receiving a digitized cardiac signal, computing a power spectral density (PSD) or multiscale entropy (MSE) of the digitized cardiac signal, and evaluating heart function based on the PSD or MSE is provided. Systems and computer program products for doing same are also provided.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: August 2, 2022
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Yael Yaniv, Aviv Rosenberg
  • Patent number: 11369304
    Abstract: Disclosed herein are a system and a method for volitional electromyography (vEMG) signal detection from an EMG signal when functional electrical stimulation (FES) is applied. The system for vEMG signal detection includes a receiver for receiving data from an EMG electrode when FES is applied, a memory for storing a program for detecting a vEMG signal using the received data, and a processor for executing the program, wherein the processor cuts the data received from the EMG electrode disposed at a predetermined position, calculates a difference between data for previous FES and data for current FES, and detects the vEMG signal using the calculated difference.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: June 28, 2022
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Joon Young Jung, Bae Sun Kim, Yong Ki Son, Dong Woo Lee, Ja Beom Gu, Hyung Cheol Shin
  • Patent number: 11357983
    Abstract: Systems and methods for applying electrical stimulation to different sub-populations of targeted neurological tissue for optimizing spinal cord stimulation are disclosed. According to an aspect, a method includes applying a first pattern of electrical stimulation to a first sub-population of targeted neurological tissue of a subject. The method also includes applying a second pattern of electrical stimulation to a second sub-population of targeted neurological tissue of the subject, the second pattern of electrical stimulation being applied at a different frequency than the first pattern of electrical stimulation.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 14, 2022
    Assignee: Duke University
    Inventors: Warren M. Grill, Tianhe Zhang
  • Patent number: 11331045
    Abstract: The disclosed systems and methods are generally directed to interpreting neuromuscular signals. The system includes (A) a plurality of neuromuscular sensors that detect a plurality of neuromuscular signals from a user and (B) at least one multiplexer in communication with the plurality of neuromuscular sensors and that is capable of dynamically adjusting neuromuscular sensor processing based on neuromuscular signal characteristics. A computer processor is programmed to (i) receive a set of neuromuscular signals from the plurality of neuromuscular sensors, (ii) determine, via a real-time system, at least one signal characteristic included in a neuromuscular signal, where the neuromuscular signal is associated with a first neuromuscular sensor included in the plurality of neuromuscular sensors; and (iii) dynamically reconfigure the processing of neuromuscular signals from the plurality of neuromuscular sensors based on an output from the multiplexer.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: May 17, 2022
    Assignee: Facebook Technologies, LLC
    Inventors: Anthony D. Moschella, Daniel Wetmore, Patrick Kaifosh, Adam Al-natsheh, Tudor Giurgica-Tiron, Qiushi Mao
  • Patent number: 11331489
    Abstract: In some examples, a medical device is configured to deliver high dose electrical stimulation therapy to a patient by at least generating and delivering an electrical stimulation signal having a relatively high duty cycle, and a stimulation intensity less than a perception or paresthesia threshold intensity level for the patient. The pulses of the electrical stimulation signal may each have a relatively low amplitude, but due at least in part to a relatively high number of pulses per unit of time, a dose of the electrical stimulation may be high enough to elicit a therapeutic response from the patient.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: May 17, 2022
    Assignee: MEDTRONIC, INC.
    Inventor: Lisa M. Johanek
  • Patent number: 11324408
    Abstract: This invention provides methods for mapping and ablating renal nerves to treat disease caused by systemic renal nerve hyperactivity, e.g. hypertension, heart failure, renal failure and diabetes. Also provided are catheters for performing the mapping and ablating functions.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: May 10, 2022
    Assignee: SYMAP MEDICAL (SUZHOU), LTD
    Inventor: Jie Wang
  • Patent number: 11324949
    Abstract: A system for electrically stimulating one or more muscle groups includes a processor-readable storage medium storing, in association with each of at least one muscle group, digital exertion data representative of one or more action potentials captured during an exertion regime from the muscle group of a respective subject; a signal generator for generating electrical stimulation signals; processing structure configured to automatically retrieve digital exertion data from the processor-readable storage medium and to automatically cause the signal generator to generate new electrical stimulation signals based on the digital exertion data; and a signal distributor for conveying the new electrical stimulation signals from the signal generator to one or more respective muscle groups of at least one different subject.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: May 10, 2022
    Assignee: Eleway Industries Inc.
    Inventors: Amir Jomehri, Jeffrey Burton, Chengkai Yao
  • Patent number: 11318300
    Abstract: Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: May 3, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Niloy Bhadra, Narendra Bhadra, Kevin L. Kilgore, Scott Lempka, Tina Vrabec, Manfred Franke
  • Patent number: 11317831
    Abstract: A wearable patient monitoring device in a patient monitoring system includes motion sensors generating sensor output signals in response to sensed patient motion, and a processor that processes the sensor output signals according to a template-matching monitoring process that includes (1) detecting occurrence of a first event of a multi-event movement based on first values of the sensor output signals, the multi-event movement having a finite-state-machine (FSM) representation as a sequence of states corresponding to events and expected values of the sensor output signals of the multi-event movement, (2) detecting occurrence of remaining events of the multi-event movement based on a sequence of subsequent values of the sensor output signals, and (3) upon detecting a last event of the multi-event movement, generating an output signal indicating detection of the patient performing the multi-event movement.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 3, 2022
    Inventor: Vishnu Nair
  • Patent number: 11266833
    Abstract: A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: March 8, 2022
    Inventors: David A. Friedenberg, Po-Hsu Chen, Samuel Colachis, Nicholas Annetta, Douglas E. Boyd, Collin Dunlap, Ian W. Baumgart, Herbert S. Bresler
  • Patent number: 11266835
    Abstract: The invention concerns an arrangement comprising an electrical stimulator (1), a programming system (25) for assisting a user in programming it for performing a determined body movement by neuromuscular stimulation; and an input device (24) operable by the user. The programming system is configured to: decompose the neuromuscular movement into distinct actions (31), select one of them, and configuring the electrical stimulator with the electrical stimulation parameters associated with the selected action. The programming system is further configured to select one electrical stimulation parameter among the electrical stimulation parameters associated with the selected distinct action, and, in a cycle performed while the electrical stimulator is connected to the user's body: to receive a value of the selected electrical stimulation parameter through the input device (24); and to configure the electrical stimulator (1) with the received value of the selected electrical stimulation parameter.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: March 8, 2022
    Assignee: MINDMAZE HOLDING SA
    Inventors: Andrea Maesani, Andrea Biasiucci
  • Patent number: 11259942
    Abstract: A system or method for motor rehabilitation of a paretic limb including: a first plurality of sensors for registering brain neurosignals; a body-actuator; a hybrid brain machine interface for decoding brain neurosignals into movements of the body-actuator; a second plurality of EMG sensors couplable to the paretic limb for registering its EMG activity; a device for providing the patient with instructions relative to a series of exercises and/or tasks to be carried out with the paretic limb; wherein upon carrying out a series of training sessions, each session comprising at least a set of such instructions, the hybrid brain machine interface is configured to switch between controlling the movements of the body-actuator based on the decoded brain neurosignals and a hybrid control of the movements of the body-actuator, when a significant level of decodable EMG activity has been registered, the hybrid control being an EMG-gated brain control.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 1, 2022
    Assignees: FUNDACION TECNALIA RESEARCH & INNOVATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, EBERHARD KARLS UNIVERSITAET TUEBINGEN
    Inventors: Ander Ramos Murguialday, Niels Birbaumer, Jose Miguel Carmena Ramon
  • Patent number: 11247048
    Abstract: A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulati
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: February 15, 2022
    Assignee: Bioness Neuromodulation Ltd.
    Inventors: Eyal Lasko, Shmuel Springer, Mark Rubin, Amit Dar
  • Patent number: 11241195
    Abstract: A system includes an endotracheal tube having a plurality of electrodes, wherein the electrodes include at least one stimulating electrode configured to stimulate tissue of a patient and at least one monitoring electrode configured to monitor at least one nerve of a patient. The system includes a nerve integrity monitor device configured to send a stimulation signal to the at least one stimulating electrode to evoke a reflex response, and configured to receive a monitoring signal from the at least one monitoring electrode.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: February 8, 2022
    Assignee: Medtronic Xomed, Inc.
    Inventors: Kevin L. McFarlin, David C. Hacker, Anirudhan Narasimhan
  • Patent number: 11219757
    Abstract: An apparatus and method for ischemic muscle training or recovery provides coordinated blood flow restriction and electrical muscle stimulation. The apparatus includes a blood flow occluding element for restricting blood flow to a target muscle or muscle group in a user, and measuring resting systolic blood pressure (SBP). The apparatus also includes an electrical muscle stimulator including at least one electrode and a control unit which, upon activation, sends low amplitude electric pulses through the target muscle or muscle group forcing the targeted muscle to contract while the blood flow is restricted.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: January 11, 2022
    Assignee: University of Guelph
    Inventor: Jamie Francis Burr
  • Patent number: 11198003
    Abstract: A method for optimization of the stimulation pattern of a set of implanted electrodes in excitable tissue of a patient is disclosed, wherein it comprises the steps of: (a) choosing a first group of a certain number of from said set of implanted electrodes, (b) stimulating the excitable tissue electrically by said first group of electrodes, (c) registering information provided by the patient, (d) assigning each electrode of said first group of electrodes a value related to said information, wherein these steps are repeated for one or more further groups of said certain number of electrodes chosen from said set of implanted electrodes, wherein each electrode may be included in one or several groups, wherein the total assigned value for each electrode is calculated, and wherein electrodes having a total assigned value exceeding a predetermined value or a predetermined number of the electrodes having the highest total assigned value are chosen to be included in said stimulation pattern, as well as a method for tr
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: December 14, 2021
    Assignee: NEURONANO AB
    Inventors: Jens Schouenborg, Hjalmar Bjartmarz
  • Patent number: 11166667
    Abstract: This system for identifying information represented by biological signals is configured so as to detect biological signals (S501), analyze the detected biological signals and then output feature data (S502), determine the respective similarities between the feature data and a plurality of teaching data (S503), store the similarities per time in a time series (S504), and determine information represented by the biological signals on the basis of the plurality of similarities within a prescribed period among the stored similarities in the time series (S505).
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 9, 2021
    Assignee: Meltin MMI Co., Ltd.
    Inventors: Masahiro Kasuya, Tatsuya Seki