Abstract: A respiration implant system for a patient with impaired breathing includes one or more temperature sensors configured for placement into an inner wall tissue along an airway passage of the patient and configured to measure temperature in the inner wall tissue in order to produce a temperature signal based on the measured temperature. The system further includes a pacing processor configured to receive the temperature signal from the temperature sensor and to generate a respiration pacing signal based on the temperature signal that is synchronized with a breathing cycle of the patient and a stimulating electrode configured to deliver the respiration pacing signal from the pacing processor to respiration neural tissue of the patient to facilitate breathing in the patient. The respiration implant system may be used as a laryngeal pacemaker system.

Abstract: NMES systems and methods for stimulating muscle tissue, and in some embodiments deep muscle tissue. The impedance near the surface of the skin is controllably increased to increase the percentage of energy delivered to a subject that stimulates muscle tissue.

Abstract: In one embodiment, a method of operating an implantable pulse generator comprises: providing power to a voltage converter at a first voltage level; outputting a second voltage level by the voltage converter, the second voltage level being a variable voltage level that is controlled by a control signal provided to the voltage converter, the second voltage level being provided to pulse generating circuitry of the implantable pulse generator, the second voltage level being selectable from a plurality of voltages including non-integer multiples of the first voltage level; generating pulses by the pulse generating circuitry, the pulse generating circuitry including current control circuitry for controlling the pulses to cause the pulses to provide substantially constant current to tissue of the patient; and applying at least two different control signals to the voltage converter during individual pulses to provide successively increasing voltages to the pulse generating circuitry during a respective pulse.

Abstract: A method of electro-therapeutic stimulation uses an electrical signal with a periodic-exponential background pulse over a controllable periodic-exponential main pulse. By properly setting the signal and moving electrodes to proper locations on the body, the signal is used to electro-therapeutically return a patient to a state of neurological balance, to identify specific cellular disruption locations, to treat the identified cellular disruption locations including performing a pain associated movement, and to neurologically train from a facilitator muscle to one or more receiver muscles.

Abstract: A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.

Abstract: A functional electrical stimulation method and device that starts electrical stimulation of a first leg of a person when a distance between a reference point on the person's first leg and the surface on which the person walks exceeds a first predetermined value and stops electrical stimulation of the first leg of the person when the distance between the reference point and the surface falls below a second predetermined value, wherein the first and second predetermined values are calculated from an initial measurement of the distance between the reference point and the surface when the person is standing still and the first leg is perpendicular to the surface. The first predetermined value is greater than the second predetermined value. The method and device produce a more natural gait in persons with drop foot, and minimize the time electrical stimulation is applied to muscles so as to minimize muscle fatigue.

Abstract: The present invention relates a system that can configure a stimulus for functional electrical stimulation (“FES”) to maintain a constant muscle force while delaying the onset of muscle fatigue and a related method of use. The stimulus can be delivered to a nerve via a set of multiple electrode contacts according to a stimulation parameter that maximizes a joint moment associated with the stimulus and minimizes the overlap between pairs of contacts. The joint moment can be related to the muscle force, and the overlap can be related to the onset of muscle fatigue.

Abstract: Systems and methods are provided for stimulating motor units. An electrode array includes a plurality of electrodes configured to provide stimulation to respective motor units of a plurality of independent, mutually agonist motor units. A stimulator assembly is configured to provide a stimulation current to each electrode of the plurality of electrodes. The stimulation current is provided such that a sum of respective time-varying moments at the plurality of motor units remains substantially constant and non-zero.

Abstract: A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Abstract: A method and device for reducing muscle tension through electrical manipulation applies a low level current to muscles of a user. Each muscle has two electrodes applied thereto, one for passing the current from the device to the muscle, and the other for receiving the current from the muscle to complete the circuit. The device has several channels, one for each pair of electrodes, and current is passed through a muscle at a level below the threshold required to cause the muscle to contract. The device is programmed to automatically apply an alternating current at predetermined frequencies for predetermined time periods to each muscle of the user that is being treated. A method of diagnosing an ailment using the device is provided.

Abstract: Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Abstract: A site-specific deep brain stimulation for enhancement of memory is described. A method of the site-specific deep brain stimulation for enhancement of memory may include implanting intracranial depth electrodes in a patient, wherein the electrodes are placed in right and/or left entorhinal regions, and stimulating the electrodes with current set below an after-discharge threshold. The method may include stimulation at a specific brain site in the medial temporal lobe, stimulation (ODTS) at specific stages of information processing. A system for site specific deep brain stimulation of entorhinal regions during specific stages of information processing is also described.

Abstract: An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.

Abstract: A neuromodulation system configured for providing sub-threshold neuromodulation therapy to a patient. The neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, modulation output circuitry configured for delivering electrical energy to the electrical terminals in accordance with at least one modulation parameter, thereby providing therapy to the patient at a sub-threshold level and control circuitry configured for controlling the modulation output circuitry in a manner that pseudo-randomly varies a value of the at least one modulation parameter based on a previous value of the at least one modulation parameter, such that the delivered electrical energy is continually maintained at the sub-threshold level.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.

Abstract: Electronic components, including a transceiver (220) for two-way wireless communications, are carried by a freely roaming animal (190) such as a rat. Electrodes are implanted in the brain of the animal to provide cues and rewards to the animal to achieved desired behaviors, including controlling the direction and speed of movement of the animal, and training the animal to recognize odors. Network interface components (265) allow a network of the animals to work together. Sensors (225, 230, 235, 245, 255, 260) carried by the animal provide information to a remote base station regarding, e.g., heading and location. Chemical or gas sensors, along with a video camera and a microphone provide information regarding an environment of the animal. The animal can search for people buried in rubble piles, and detect explosives, chemicals or other dangerous materials. A vehicle (500) for deploying the animal is also provided.

Abstract: A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.

Abstract: An electrical stimulation system and method for generating a stimulation signal for at least two electrodes coupled to a body part in a functional electrical stimulation system. One example embodiment includes a controller unit operable for receiving stimulation parameters and a trigger signal, and in response to receiving the trigger signal, outputting control signals based on the stimulation parameters. A voltage conversion module coupled to the unit receives the control signals and converts a supply voltage based on the received control signals. A switch receives the converted supply voltage at a first terminal and outputs a simulation signal at a second terminal. Outputting of the converted supply voltage at the second terminal by the switch is controlled by a driver module based on the received control signals.

Abstract: A method and system which provides wireless, noninvasive electrical stimulation to different muscle groups to allow the user to conduct physical activities, such as walking, by stimulating various muscle groups in the body at the correct times of activation or by stimulating muscle groups in a simulation mode when standing, sitting or lying down, whereby walking is not required to stimulate the various muscle groups. The system provides a small portable wearable system which utilizes available software, including Bluetooth technology, to provide electrical nerve stimulating pulses with low current, minimal phase charge which is controlled remotely and induce desired muscle contraction with increased comfort for the user. The present method and system applies electrical stimulation with accurate timing, based on a three-dimensional motion sensor, as a trigger to initiate stimulation and which is adapted to turn itself on and off when not walking.

Abstract: A universal closed-loop functional electrical stimulation system comprising at least one electrode assembly adapted to deliver an electrical stimulation signal to the central nervous system, peripheral nervous system, or muscles of a user, a sensor system adapted to detect a mechanical response to a muscle stimulation signal of at least one muscle associated with a muscle group stimulated through the nervous system or proximate to the electrode assembly. An electrical stimulation device operably coupled to at least one electrode assembly and the sensor system, the electrical stimulation device including a control system to automatically receive feedback from at least one characteristic of the muscle from the detected muscle response and adjust at least one parameter of the muscle stimulation signal in real-time and in response thereto and a programmed microprocessor for controlling said electrical stimulation and receiving input from said sensor system.

Abstract: Apparatus for rehabilitating a patient who has a paretic body part, the apparatus comprising: a) at least one electromyograph (EMG) sensor adapted to being applied to a voluntary muscle of a healthy body part of the same type as the paretic body part, which at least one sensor produces at least one EMG signal; b) a neuromuscular electrical stimulation (NMES) device adapted for stimulating at least one voluntary muscle of the paretic body part; and c) a controller which controls the NMES device, making the amplitude of stimulation of the paretic body part at least partly dependent on the EMG signal from the healthy body part.

Abstract: An improved external charger for an implantable medical device is disclosed in which charging is at least partially controlled based on a determined position of the external charger, which position may be indicative of the pressure between the external charger and a patient's tissue. The improved external charger includes one or more position determination elements, e.g., an accelerometer or gyrometer, and control circuitry for controlling the external device in accordance with the determined position. The determined position of the external charger can be used to control charging, for example, by suspending charging, by adjusting the intensity of charging, by adjusting a maximum set point temperature for the external charger, or issuing an alert via a suitable user interface. By so controlling the external charger on the basis of the determined position, the external charger is less likely to create potentially problematic or uncomfortable conditions for the user.

Abstract: Disclosed herein is a method for simply inducing an anti-apoptotic effect and/or an anti-necrotic effect in a living cell with good control without administering any drug. The method includes applying an alternating-current voltage to the living cell so that an electric current of 25 ?A or higher but 75 ?A or lower flows to induce an anti-apoptotic effect and/or an anti-necrotic effect in the living cell. The living cell used may be a cultured cell. The alternating-current voltage may be applied to a stage member on which a container holding the living cell is placed.

Abstract: Methods for treating polycystic kidney disease with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery of a kidney of a patient. One or more measurable physiological parameter corresponding to the polycystic kidney disease can thereby be reduced. Moreover, central sympathetic drive in the patient can be reduced in a manner that treats the patient for the polycystic kidney disease. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to cryotherapeutically cool the renal nerve or to deliver an energy field to the renal nerve.

Abstract: A method is provided for producing an arthropod comprising introducing a microsystem such as a MEMS device into an immature arthropod under conditions that result in producing an adult arthropod with a functional microsystem permanently attached to its body. A method is also provided for producing a robotic apparatus. The method can comprise introducing a microsystem such as a MEMS device into an immature arthropod under conditions that result in producing a robotic apparatus with the microsystem permanently attached to the body of the adult arthropod.

Abstract: A system and method for managing pain, configured to be worn by a patient, comprising an electrode array comprising a first electrode and a second electrode for providing a TENS treatment to the patient; a connector configured to couple at least one of the first electrode and the second electrode to an electronics subsystem; a muscle twitch sensor subsystem configured to detect a muscle twitch profile induced by the electrode array at the patient; and an electronics subsystem comprising a power module configured to power the system, a pulse generator coupled to the electrode array and configured to transmit the TENS treatment, and a control module configured to receive an input, from the muscle twitch sensor subsystem, characterizing the muscle twitch profile, wherein the electronics subsystem is configured to modulate a parameter of the TENS treatment based upon the input, until a threshold is satisfied.

Abstract: The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

Abstract: A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract: A device for identifying appropriate nerve stimulation points on a patient is described, for use with an electrical stimulation device. In a first embodiment, the device includes electrodes located on a flexible substrate, a conductive gel layer overlying the electrodes, and a partially conductive removable cover overlying the gel layer. The device may be operated initially with the cover in place to allow reduced stimulation to identify a suitable nerve stimulation point. The cover may then be removed, and the device operated at the identified point. The cover may include perforations allowing the gel to contact the patient; or may be a sacrificial gel layer.

Abstract: An Analog/Digital (A/D) modulation apparatus in a communication system supporting multiple communication modes and a method for controlling the same are provided. The A/D modulation apparatus includes an A/D modulation module having a structure in which a plurality of unit loops are extended by a serial connection, a control module configured to determine a modulation resolution needed for a communication mode to be used, a signal transfer control module including an input control module configured to transfer or block an intermediate output signal of a basic loop, as an input signal of an extended loop serially connected to the basic loop, in response to the modulation control bits provided from the control module, and an output module configured to generate a final digital-modulated signal based on a final output signal of the basic loop and a final output signal of the extended loop.

Abstract: A device for controlling operation of a nerve-modulating implant unit from a location external to the body of the subject is provided. The device may include a flexible substrate configured for removable attachment to a subject's skin, a primary antenna disposed on the flexible substrate, and at least one processing device. The processing device may be configured to cause generation of a modulation control signal and application of the modulation control signal to the primary antenna in order to wirelessly transmit the modulation control signal to a secondary antenna on the implant unit to cause modulation of at least one nerve using energy transmitted wirelessly from the primary antenna to the secondary antenna, and cause a plurality of predetermined alterations of at least one characteristic of the modulation control signal over successive applications of the modulation control signal during a therapy period.

Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.

Abstract: A functional electrical stimulation method for rehabilitating, treating, retraining, and/or otherwise improving upper extremity mobility and control in persons having impaired or disabled upper extremities due to stroke or spinal cord injury, comprising stimulation of the lumbricalis muscles.

Abstract: An airway of a patient is protected from intrusion of contaminants by monitoring muscles of the patient to detect an attempted cough or swallow, and applying an electrical stimulus to the neck of the patient, varying amplitude and/or frequency over time, the applied electrical stimulus operates to promote an efficacious cough or swallow. The electrical stimulus induces a voltage within a range of greater than zero volts and less than 20 volts, and the frequency have patterned changes between at least about 4 Hz to not more than about 30 Hz. The monitoring is carried out by an electronic device, and the patient may indicate to the electronic device that a swallow or cough is impending.

Abstract: A method for stimulating a facial muscle includes the steps of mapping a facial nerve being connected to the facial muscle, locating the facial muscle in response to the mapping of the facial nerve and stimulating the facial nerve by applying an electrode and stimulating the facial nerve with current. The step of mapping includes the step of applying current to the cheek by an electrode and moving the electrode in response to the reaction of applying current to the cheek.

Abstract: The present invention involves systems and methods for determining nerve proximity, nerve direction, and pathology relative to a surgical instrument based on an identified relationship between neuromuscular responses and the stimulation signal that caused the neuromuscular responses.

Abstract: The invention relates to training and can be used for learning and/or developing movement skills, fixing dynamic stereotypes and for training movement coordination. The aim of the invention is to provide a trainee with on-line correcting tactile feedback during training and to improve techniques and rate of a movement by bringing it as close as possible to a reference movement. The inventive training method consists, when learning a movement, in digitizing said movement, in comparing it with the digitized pattern of a reference movement and, if the trainee deviates from the reference movement, in receiving by said trainee a tactile feedback (tactile action) for on-line correcting said movement.

Abstract: A device useful in treating decreased laryngeal elevation and for muscle re-education and rehabilitation is provided. The device is suitable for transmitting an electrical stimulus and can comprise a series of electrically conductive fibers oriented at an angle such that the fibers are parallel to muscle fibers of the laryngeal elevated musculature in the submandibular region of a patient.

Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.

Abstract: Devices, systems, and methods for automated optimization of muscle stimulation energy. In some embodiments the disclosure optimizes stimulation parameters and/or stimulation location.

Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.

Abstract: An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source.

Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

Abstract: Methods, devices, and kits comprising a magnetic system for automation of blinking, or to provide temporary or permanent assistance with opening or closure of the eyelids to treat disorders of the eyelids, including lagophthalmos and ptosis.

Abstract: Devices and methods for preventing knee sprain injuries. To protect the knee joint from knee sprain injuries, the device comprises a sensing part configured to sense data associated with knee motion; an analyzing part configured to analyze the knee motion data to determine a knee articulation; and a stimulating part configured to stimulate one or more lower limb muscles to initiate an earlier muscle reaction than would naturally occur in response to the determined knee joint articulation. The determined knee joint articulation may include knee joint articulation or a particular type of articulation such as a knee sprain movement associated with knee sprain. The methods involve sensing data associated with knee joint motion, analyzing the data to determine a knee joint articulation; and stimulating one or more lower limb muscles to initiate an early muscle reaction within the determined knee joint articulation.

Abstract: A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

Abstract: The present invention involves a system and methods for assessing the state of the neuromuscular pathway to ensure further nerve tests aimed at detecting at least one of a breach in a pedicle wall, nerve proximity, nerve direction, and nerve pathology, are not conducted when neuromuscular blockade levels may decrease the reliability of the results.

Abstract: A hybrid method is provided for modulating upper airway function in a subject. The method includes applying first and second therapy signals to the subject to modulate at least one extrinsic laryngeal muscle and at least one intrinsic laryngeal muscle to synergistically control laryngeal motion and vocal fold movement, respectively.

Abstract: A stimulator is adapted to electrically stimulate a muscle of a patient. A detector is adapted to detect a response of the stimulated muscle. A processor is operable to obtain a plurality of parameters indicative of muscle relaxation of the patient based on the detected response. A display is operable to display the parameters simultaneously while showing chronological changes thereof.