Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue (e.g., an organ) that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell. In one embodiment, the energy is applied to cause competing or opposing effects for bi-directional control of physiological processes.

Abstract: The present disclosure provides systems and methods for wirelessly charging an implantable medical device. An external charging device includes a coil, signal generating circuitry to drive current through the coil at a charging frequency to induce current in a second coil in the implantable medical device, monitoring circuitry to generate an output signal to monitor charging operations, and a comb filter. The comb filter is configured to apply filtering to the output signal to remove noise from the output signal, wherein the filtering is applied based on the charging frequency. The external charging device is configured to process the filtered output signal to detect a circuit state of charging circuitry of the implantable medical device during charging operations, and the external charging device is configured to vary the charging frequency based, in part, on detection of the circuit state of the charging circuitry of the implantable medical device.

Abstract: An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

Abstract: One embodiment provides a system controller circuitry for mitigating a neurophysiological disorder. The system controller circuitry includes an optimization module, a feedback control module, and a model update module. The optimization module is configured to predict a sequence of control inputs based, at least in part, on a fractional order model of a neurophysiological system. A duration of the predicted sequence of control inputs corresponds to a prediction horizon. The feedback control module is configured to provide at least a portion of the sequence of control inputs to the neurophysiological system based, at least in part, on a current state of the neurophysiological system. A duration of the at least a portion corresponds to a control horizon. The model update module is configured to update one or more of a model parameter and/or an objective function parameter at an update interval, based, at least in part, on a recent state of the neurophysiological system.

Abstract: A neuromodulation apparatus and method of using the same. The neuromodulation apparatus includes a plurality of electrodes each of the plurality of electrodes having an electrically conductive element applicable to or under a skin of a patient, a pulse generator electrically connected to each of the plurality of electrodes for transmitting electrical pulses to the plurality of electrodes and a control unit coupled to the pulse generator and adapted to measure a resistance and/or a current-voltage characteristic between at least two electrodes of the plurality of electrodes. The control unit is adapted to control a shape of the electric pulses based on the measured resistance and/or current-voltage characteristic.

Abstract: An architecture is disclosed for an Implantable Pulse Generator having improved compliance voltage monitoring and adjustment software and hardware. Software specifies which stimulation pulses are to be measured as relevant to monitoring and adjusting the compliance voltage. During compliance voltage monitoring, “high-side” anode electrode node voltages referenced to the compliance voltage are considered as are “low-side” cathode electrode node voltages referenced to ground. Translation stages are used to convert only the anode electrode node voltages to ground as low-side signals. This allows compliance voltage monitoring and adjustment to occur using only low-side signals, which eases sensing and reduces design complexity.

Abstract: An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

Abstract: Systems and methods for gesture control are described. In some embodiments, a system for assessing a physiological state of a user. The system may include the wearable device comprising one or more electrodes configured to be disposed adjacent to an external surface of the skin portion. A first timestamp may be determined. The first timestamp may indicate a first time at which a stimulus is presented to the user. A second timestamp indicating a second time at which the biopotential signals indicate an intention by the user to perform a responsive action may be determined. Based at least on the first timestamp and the second timestamp, determine a subject response time for the user. The subject response time may be compared to a baseline response time for the user to generate an assessment of a physiological state of the user.

Abstract: Systems and methods for gesture control are described. In some embodiments, a system for assessing a physiological state of a user. The system may include the wearable device comprising one or more sensors configured to be disposed adjacent to an external surface of the skin portion. A first timestamp may be determined. The first timestamp may indicate a first time at which a stimulus is presented to the user. A second timestamp, which indicates a second time at which physiological data indicates a responsive action of the user, may be determined. Based at least on the first timestamp and the second timestamp, determine a subject response time for the user. The subject response time may be compared to a baseline response time for the user to generate an assessment of a physiological state of the user.

Abstract: Measurement devices include a housing featuring a channel, where the housing is dimensioned to be worn in an oral cavity of a user and the channel is positioned such that at least some of the user's teeth are positioned in the channel when the housing is worn, a first sensor positioned within or on a surface of the housing, where the first sensor is configured to generate a first measurement signal that includes information about a position of the measurement device, and a second sensor positioned within or on a surface of the housing, where the second sensor is configured to generate a second measurement signal that includes information about at least one of a biochemical and an electrical property of the user's oral cavity.

Abstract: Systems and methods for closed-loop control of electrostimulation while avoiding, or maintaining a substantially low level of, evoked neural activity are disclosed. A system comprises an electrostimulator to deliver a stimulation pulse train, a sensing circuit to sense evoked responses to respective pulses in the pulse train, and a controller to detect an evoked neural activity from an averaged evoked response by averaging evoked responses to respective pulses. The averaging operation can be controlled by a noise level of the averaged evoked response, or by a count of epochs (pulses) being used for averaging. Responsive to the evoked neural activity satisfying a detection criterion, the controller recursively adjusts stimulation parameters until the detection criterion is no longer satisfied. The electrostimulator delivers electrostimulation according to the recursively adjusted stimulation parameters.

Abstract: An output signal driver includes a positive output node, a negative output node, a power supply input node, a power supply common node, a charging capacitor, a discharging capacitor, a current source, a current sink, a first switch, a second switch, and a controller. The charging capacitor is coupled to the power supply input node. The discharging capacitor is coupled to the negative output node. The current source is coupled between the power supply input node and the positive output node. The current sink is coupled between the positive output node and the power supply common node. The first switch is coupled in parallel with the current source. The second switch is coupled in parallel with the current sink. The controller is coupled to the current source, the current sink, the first switch, and the second switch to apply either complementary constant current pulses or complementary constant voltage pulses to the positive output node.

Abstract: A method for biosignal data transformation can include: determining a set of biosignal data, determining a brain state representation (e.g., an embedding) based on the biosignal data, and determining a biomarker value based on the brain state representation. The method can optionally include training a model (e.g., training a model used to determine the brain state representation), and/or any other suitable steps. A system for biosignal data transformation can include a biosignal device and a computing system.

Abstract: A portable endoscopic system comprising an imaging unit for an endoscopic procedure. The imaging unit has an imaging coupler for receiving imaging information from an imaging assembly of an endoscope; a display integrated into a housing of the imaging unit; an image processing unit for processing the received imaging information into images of a time series and to displaying the image in real-time; a motion sensor configured to detect a motion of the housing; and a detection processing unit. The detection processing unit is configured to classify at least one anatomical feature in each image of the time series based on an artificial intelligence classifier; determine a confidence metric of the classification; determine a motion vector based on the detected motion; and display, concurrently with the corresponding image, the classification of the at least one anatomical feature, the determined confidence metric, and the determined motion vector.

Abstract: An artificial intelligence (AI)-based system and method for controlling operations of neuromodulation devices based on physiological parameters of users is disclosed. The AI-based system comprises one or more physiological parameters sensing endpoint devices and one or more server devices. The one or more physiological parameters sensing endpoint devices are configured to determine the one or more physiological parameters of each user. The one or more server devices comprises a data-obtaining subsystem, a data-processing subsystem, an operational parameter generation subsystem, a data recommendation subsystem, and a plurality of modules. The AI-based system is configured to process the obtained at least one of: the one or more physiological parameters and user-centric data to generate one or more user-centric operational parameters for controlling the operations of the one or more neuromodulation devices.

Abstract: Regulator circuitry for producing a regulated output voltage in an implantable stimulation device and associated methods are disclosed. The regulator circuitry is particularly useful where a load current drawn from the output voltage involves transients, such as occurs when the output voltage is used to power a charge pump that creates a higher power supply voltage (e.g., a compliance voltage) in the device. The output current is sampled and downscaled in the regulator, and is further mirrored and filtered. This filtered current provides a control voltage in which transients are minimized and smoothed, and which is more suitable for use as a feedback voltage when producing the output voltage.

Abstract: An integrated circuit includes: a radio-frequency (RF) to direct current (DC) rectifying circuit coupled to one or more antenna on an implantable wirelessly powered device, the rectifying circuit configured to: rectify an input RF signal received at the one or more antennas and from an external controller through electric radiative coupling; and extract DC electric power and configuration data from the input RF signal; a logic control circuit connected to the rectifying circuit and a driving circuit, the logic control circuit configured to: generate a current for the driving circuit solely using the extracted DC electrical power; in accordance with the extracted configuration data, set polarity state information for each electrode; and a driving circuit coupled to one or more electrode, the driving circuit comprising current mirrors and being configured to: steer, to each electrode and via the current mirrors, a stimulating current solely from the generated current.

Abstract: An example of an apparatus for percutaneously delivering neurostimulation energy to a patient and sensing from the patient using a test device placed externally to the patient is provided. The apparatus may include a stimulation lead, a sensing reference electrode, a sensing wire, and a connection system. The stimulation lead may be configured to be percutaneously introduced into the patient to place the one or more electrodes in the patient. The sensing reference electrode may be configured to be placed in the patient. The sensing wire may be connected to the sensing reference electrode and configured to be percutaneously introduced into the patient to place the sensing reference electrode in the patient. The connection system may be configured to mate the lead connector and the wire connector and to provide electrical connections between the lead connector and the test device and between the wire connector and the test device.

Abstract: An electrical stimulation device is provided. The electrical stimulation device includes a boost circuit, a voltage selecting circuit and a control circuit. The boost circuit generates a plurality of voltages, wherein the voltages have different voltage values. The voltage selecting circuit is coupled to the boost circuit and selects one voltage according to a reference voltage on a tissue impedance to generate an output voltage. The control circuit is coupled to the boost circuit and in response to electrical stimulation; it transmits a control signal to enable the boost circuit.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.

Abstract: This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

Abstract: An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.

Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

Abstract: Systems for delivering therapy to a nerve in a patient may comprise a plurality of sensors, such as a cardiac sensor, a disease activity sensor, and a bodily activity sensor, an implantable pulse generator, and an implantable signal delivery device. The implantable signal delivery device may be configured to deliver a stimulation signal to the nerve.

Abstract: Methods and systems for providing closed loop control of stimulation provided by an implantable stimulator device are disclosed herein. The disclosed methods and systems use a neural feature prediction model to predict a neural feature, which is used as a feedback control variable for adjusting stimulation. The predicted neural feature is determined based on one or more stimulation artifact features. The disclosed methods and systems can be used to provide closed loop feedback in situations, such as sub-perception therapy, when neural features cannot be readily directly measured.

Abstract: An electric field cancer treatment apparatus using a rotating alternating current (AC) electric field according to an embodiment of the present disclosure includes a plurality of electrode pairs configured to transmit AC electric fields to a target area in a body, a plurality of AC electric field generators respectively connected to the plurality of electrode pairs and configured to generate AC electric fields to be applied to the plurality of electrode pairs, and a controller configured to control generation of AC electric fields by the plurality of AC electric field generators.

Abstract: A system for electrical stimulation of the salivary glands for the treatment of dry mouth is disclosed. In one embodiment, the system includes a headset with an electronic control module, placed on the back head, and a stimulating module, placed on the area to be stimulated. Both modules are connected by an elastic arm. The stimulating module provides one or more pairs of electrodes in contact with neuro-sensitive areas of a patient, and is anchored in the ear canal. The position of the electrodes is adjustable for optimized stimulation. The system may be operated by control bottoms that are part of the electronic control module or by a mobile device, such as a wireless remote control, a smartphone, or a tablet. A mobile device camera may be used for correcting the placement of the electrodes.

Abstract: The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders.

Abstract: This disclosure is directed to devices, systems, and techniques for managing storing sensed information. In some examples, a system includes a memory and processing circuitry. The processing circuitry may be configured to receive evoked compound action potential (ECAP) information, wherein the ECAP information comprises information from a plurality of evoked compound action potential (ECAP) signals, receive a trigger signal requesting long-term storage of at least a portion of the ECAP information in the memory, and responsive to receiving the trigger signal, store the at least portion of the ECAP information in the memory.

Abstract: A method for treating pain or discomfort in a patient is disclosed. The method comprises stimulating a cranial nerve with an electrical signal. The pain or discomfort may be a withdrawal symptom. The cranial nerve may be in an auricular area of the patient. The cranial nerve may be cranial nerve V, cranial nerve VII, cranial nerve IX, cranial nerve X, or branches of greater and lesser occipital nerves thereof and their associated neurovascular bundles. The withdrawal symptom may result from cessation of an opioid. The method may further comprise administering a secondary drug treats one or more of the withdrawal symptoms and addiction. The secondary drug may be administered about one day to about one week after initiating the stimulating step.

Abstract: A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

Abstract: A field measurement algorithm and measuring circuitry in an implantable stimulator, and an field modelling algorithm operable in an external device, are used to determine an electric field in a patient's tissue. The field measuring algorithm provides at least one test current between two electrodes, and a plurality of voltage differentials are measured at different combinations of the electrodes. The voltage differential data is telemetered to the field modelling algorithm which determines directional resistance at different locations in the patient's tissue. The field modelling algorithm can then use a stimulation program selected for the patient and the determined directional resistances to determine voltages in the patient's tissue at various locations, which in turn can be used to model a more-accurate electric field in the tissue, and preferably to render an electric field image for display in a graphical user interface of the external device.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: A nerve stimulator according to one embodiment comprises: a pad member including a first pad portion arranged so as to come into contact with the auricle, and a second pad portion arranged so as to come in contact with the external auditory meatus; and a plurality of electrode members provided in the pad member so as to output electro-stimulation, wherein the plurality of electrode members can comprise: a first electrode member provided in the first pad portion so as to come into contact with the auricle; and a second electrode member provided in the second pad portion so as to come into contact with the external auditory meatus.

Abstract: A method and apparatus related to detecting the presence of a power transfer coil implanted in a patient are disclosed. According to the aspect, an external device of a medical implant system is provided, the external device having an external coil and processing circuitry. The processing circuitry is configured to monitor a resonance frequency associated with the external coil. When the resonance frequency changes as a distance between the external coil and an expected location of an internal coil, then the processing circuitry is configured to conclude that the internal coil has been detected. When the resonance frequency ramps up to a steady state value at a rate that falls below a rate threshold, then the processing circuitry is configured to conclude that the internal coil is connected to an internal load.

Abstract: This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.

Abstract: The disclosure concerns a method for the treatment of cervical dystonia, comprising inserting a stimulation device into the brain of a patient, the stimulation device being configured to provide electrical stimulation to affect first and second stimulation targets within the brain. The first stimulation target is the subthalamic nucleus (STN); and the second stimulation target is the ventral intermediate nucleus (VIM), or the ventralis oralis posterior thalamus (VOP), or both the ventral intermediate nucleus (VIM) and the ventralis oralis posterior thalamus (VOP).

Abstract: Provided is a monopolar skin treatment apparatus using electrical energy in a high frequency wavelength band in which a retaining ligament, a blood vessel, and a fibrous tissue of a deep part is utilized as an electricity passage to actively prevent the skin from sagging due to the aging. The mouthpiece for skin treatment includes a frame, and a ground electrode unit on the frame. The frame includes a first frame disposed in front, a second frame extending rearward from one end portion of the first frame, and a third frame extending rearward from an opposite end portion of the first frame. The ground electrode unit is integrally formed with the first frame, the second frame, and the third frame while continuously extending.

Abstract: There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.

Abstract: This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient including user indicated activities inputted from an icon driven user interface of an external patient controller device.

Abstract: Systems and methods include differential diagnosis for acute heart failure to provide treatment to a patient including determining whether the patient has cardiac volume overload, determining whether the patient has decreased abdominal venous system volume, and providing the appropriate treatment in response to the determinations. A multi-sensor system may be used to determine cardiac volume and abdominal venous system volume. Fluid redistribution treatment may be provided when cardiac volume overload is accompanied by a decrease in abdominal venous system volume. Fluid accumulation treatment may be provided when cardiac volume overload is not accompanied by a decrease in abdominal venous system volume.

Abstract: The present invention provides an actuator-equipped knee ankle foot orthosis in which a control device calculates a thigh phase angle based on an angle-related signal detected by a thigh orientation detecting means at one sampling point, applies the thigh phase angle at that sampling point to an assisting force control data, which is stored in the control device in advance and indicates the relationship between the thigh phase angle and a size of the assisting force to be imparted to a lower leg-side brace, to obtain the size of the assisting force to be imparted to the lower leg-side brace at that sampling point, and executes operational control for an actuator unit such that the assisting force having the size is output.

Abstract: Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, PTSD, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition.

Abstract: The present invention provides in part wearable devices for balance control. The wearable devices are capable of non-invasively monitoring and stimulating the wearer's vestibular system such that it produces postural responses. The wearable devices deliver low levels of electrical current to the vestibular system of a user to maintain balance. In one example, the wearable device is in the form of a pair of glasses.

Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.

Abstract: The techniques of the disclosure describe example medical devices, systems, and methods for interleaving a plurality of low-frequency electrical stimulation pulse trains delivered by a plurality of sets of electrodes of an implantable medical device (IMD) to effectively deliver a combined high-frequency electrical pulse train to a target tissue area. In one example, each set of the plurality of sets of electrodes has a unique anode and cathode. In another example, a clinician adjusts the size or shape of the target tissue area receiving the combined high-frequency electrical pulse train by selecting different combinations of the plurality of sets of electrodes.

Abstract: A biomagnetic measurement system includes a magnetism measurement apparatus configured to measure a magnetism of a target; and an electrical stimulation apparatus configured to apply a stimulation current to the target. The magnetism measurement apparatus includes a confirming unit configured to confirm a magnitude of an artifact caused by the stimulation current. The electrical stimulation apparatus is configured to output a compensation current for reducing the artifact after the stimulation current is output, based on information from the confirming unit.

Abstract: A head-mounted video camera, a processor, and a display are integrated within the head-mounted device worn by the user. The head-mounted device is configured to capture images of the environment and subject those images to specialized processing in order to diagnose and/or make up for deficiencies in the user's eyesight. Different modes of operating the device are provided that enable the user to configure the device for a specific application. The modes of operation include at least an assistive mode, a diagnostic mode, and a therapeutic mode. Each mode of operation may include further options, where each option is dedicated to a specific processing approach specific to a condition that may afflict the user, ranging from contrast sensitivity issues to strabismus.

Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.

Abstract: Methods and systems can facilitate identifying effective electrodes and other stimulation parameters, as well as determining whether to use cathodic and anodic stimulation. Alternately, the methods and systems may identify effective electrodes and other stimulation parameters based on preferential stimulation of different types of neural elements. These methods and systems can further facilitate programming an electrical stimulation system for stimulating patient tissue.