Abstract: Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Abstract: A Ni—Ti-based alloy material includes a matrix phase consisting essentially of a Ni—Ti-based alloy and having a B2 type crystal structure. A nonmetallic inclusion is present in the matrix phase, in which 99% by mass or more of the nonmetallic inclusion is a TiC-based inclusion having a NaCl type crystal structure, the TiC-based inclusion has a lattice misfit (?) in a range of 0.4238 or more and 0.4259 or less. The lattice misfit (?) is represented by Expression ?=(a1?a2)/a2, where a1 is a lattice constant (?) of the TiC-based inclusion and a2 is a lattice constant (?) of the matrix phase.

Abstract: Methods for controlling properties of structural elements of implantable medical devices, where the structural elements contain shape memory alloys (SMAs) include promoting or inhibiting in vivo formation of R-phase crystal structure or converging or separating the R-phase from the austenite phase.

Abstract: Systems and methods for delivering a device for regulating blood pressure between a patient's left atrium and right atrium are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and a second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

Abstract: Flexible expandable treatment devices are disclosed herein. One aspect of the present technology, for example, is directed to an expandable tubular structure formed of an interwoven strand and configured to be positioned in a blood vessel. The interwoven strand may be arranged to form a plurality of cells and a plurality of joints between adjacent cells. At least one of the joints may include a first strand slidably interlocked with a second strand, and at least one of the first strand and the second strand may bend back on itself to form a restriction that limits disengagement of the first strand and the second strand at the joint.

Abstract: A medical device, having a body that is tubular at least in some sections. The body can be transferred from a compressed state into an expanded state and has a circumferential wall having at least one first lattice structure and one second lattice structure. The first lattice structure and the second lattice structure form separate layers of the circumferential wall, which are arranged coaxially one inside the other and connected to each other at least at points in such a way that the first lattice structure and the second lattice structure can be moved relative to each other at least in some sections. A system having such a device is also disclosed.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: In one embodiment, a delivery assembly can comprise an annular frame, a leaflet structure positioned within the frame and secured thereto, and an outer skirt positioned around an outer surface of the frame. The annular frame can comprise an inflow end and an outflow end and can be radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. The outer skirt can comprise pericardial tissue having a fibrous parietal layer defining a first surface of the outer skirt and a serous parietal layer defining a second surface of the outer skirt. The outer skirt can be positioned such that the first surface is facing away from the frame and the second surface is facing towards the frame.

Abstract: Embodiments of the disclosure generally provide methods related to articles that display reversible photoresponsive behavior.

Abstract: The present disclosure provides collapsible medical devices that are formed from a braided tubular member configured to allow the braided tubular member to be terminated into one or more marker bands while maintaining an open lumen from a proximal end to a distal end. The collapsible medical device including the braided tubular member can be easily pulled down into a delivery sheath or other delivery device so that it is suitable for use with a number of delivery devices. The marker bands, which provide one or more attachment points for a medical device/delivery system, are positioned at one or more locations on the braid such that the braid is fixed and cannot unravel, thus preventing entanglement between individual braid wires and malformation of the device.

Abstract: A prosthetic mitral valve includes an anchor assembly, an annular strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The annular strut frame is disposed radially within the anchor assembly. An atrial end of the annular strut frame is attached to the anchor assembly such that a ventricular end of the annular strut frame is spaced away from the anchor assembly.

Abstract: The organic light emitting display device according to the exemplary aspect of the present disclosure includes a flexible substrate which includes a first area, a second area, and a bending area between the first area and the second area, and a wiring line on the bending area of the flexible substrate. The wiring line has a plurality of unit patterns having a rhombic shape. In this case, each of plurality of unit patterns shares a part of one side with the adjacent unit pattern. According to the organic light emitting display device according to an exemplary aspect of the present disclosure, a wiring line having a new shape is disposed in the bending area so that a stress which is applied to the wiring line and the protective layer formed in the bending area may be minimized.

Abstract: The present disclosure describes filter devices for deployment to body vessels where clots or emboli may need to be captured, particularly the vena cava. The filter device is of a spiral construction, having a first loop and a second loop, with a helical portion extending helically therebetween. The first and second loops assist in the filter being self-centering within a body vessel. A method of making a filter device is also disclosed.

Abstract: A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

Abstract: A braided stent having a plurality of retrieval and/or repositioning levers includes a stent body formed of a plurality of wires interbraided in a braided pattern. The repositioning and/or retrieval levers have a loop portion extending radially away from the stent body and first and second legs extending along the stent body. The levers are configured to be actuated radially inward toward the central longitudinal axis of the stent by a radially inwardly directed force to radially collapse the stent.

Abstract: Ti—Nb—Hf/Zr—(Cr) alloy shape-memory wires are provided which are suitable for use in medical devices and actuators, and methods for manufacturing such wires are provided. The present shape-memory Ti—Nb—Hf/Zr—(Cr) alloy is a superelastic wire material particularly suited for in vivo applications. For example, the present Ti—Nb—Hf/Zr—(Cr) alloy wire is radiopaque, thereby enabling surgical use of a monolithic, shape-memory alloy wire while preserving the ability to monitor the in vivo location of the wire through X-ray or other radiation-based imaging systems. In addition, the present Ti—Nb—Hf/Zr—(Cr) alloy can be manufactured to exhibit shape-memory alloy material properties without the use of nickel as an alloy constituent, thereby accommodating nickel-sensitive patients. The present Ti—Nb—Hf/Zr—(Cr) alloy can also be processed to exhibit a martensite/austenite transformation temperature near body-temperature, i.e., 37° C., so that shape-memory effects can be utilized to accomplish work in vivo.

Abstract: Pushing a self-expanding stent from one of its ends, during release of the stent at a stenting site in a bodily lumen, by proximal withdrawal of a surrounding sheath, can impose unacceptably high stresses on parts of the strut network of the stent. For location of stents in a bodily lumen, it is customary to equip the end annulus of a stent with radiopaque markers. The present invention involves arranging the markers so that they share with non-marker portions of the end annulus the stresses imposed in the stent by the end pushing, whereby the high stresses are shared more equally by all the struts of the stent in the end annulus.

Abstract: A stent has one or more redundant crests for a ring. The redundant crest is located at a Y-crown for a peak-to-valley type stent pattern in one example. The stent may also have frangible bridges for connecting links. The stent's radial stiffness decreases when a redundant crest fractures and its axial and bending stiffness decreases when a frangible bridge breaks.

Abstract: Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

Abstract: A heart valve assembly includes a heart valve, a self-expandable and collapsible stent, and a sealing member. The stent includes an inflow end and an outflow end and is configured to support the heart valve internally. The sealing member is connected to and extends circumferentially around the stent. The sealing member includes a plurality of radially outward extending protrusions comprising a fold of material of the sealing member.

Abstract: Systems and methods for treating hypertension and other maladies are implemented using an implant device that is configured with one or more coils of ribbon which form ring-like structures when deployed in a patient's vasculature and are interconnected via respective extension arms formed from at least one helical winding. In an illustrative example, the catheter is positioned in the patient's aorta near the right angle junction with renal vasculature so that the axis of the catheter is substantially perpendicular to the axis of the vasculature. Through operation of an implant device delivery system having a pigtail distal end the ribbon emerges from the catheter tip and coils into the ring-like structures which deploy into the renal vasculature so that the longitudinal axes of the device and vasculature are substantially co-linear.

Abstract: An intravascular heat exchange catheter has serpentine-like supply and return conduits circulating working fluid with a heat exchange system to warm or cool a patient in which the catheter is intubated.

Abstract: A stent and method of exhibiting radiopaque properties in a stent are disclosed, which includes a stent main body that is made of a metal, and a radiopaque marker that is made of a complete solid solution alloy having a corrosion potential of ±200 mV of a corrosion potential of the metal of the stent main body.

Abstract: A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by a plurality of flexible connectors. The hoop components are formed as a continuous series of substantially longitudinally or axially oriented radial strut members and alternating substantially circumferentially oriented radial arc members. The geometry of the struts and arcs is such that when the stent is expanded, it has very high strains within a relatively small region.

Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Abstract: The present invention relates to a delivery system for an intraluminal thin film medical device particularly well suited for occlusion of an aneurysm, vessel side branch or dissection of a body lumen or duct, such as an artery or vein. The delivery system has an outer sheath attached along the distal end of a relatively long and flexible tubular shaft. The outer sheath is capable of constraining the thin film medical device in a longitudinally stretched position, and subsequently being retracted relative to the flexible tubular shaft to release the thin film medical device from the constrained longitudinally stretched position. The delivery system may additionally have a mechanical expansion catheter substantially coaxial too, and slideably engaged within, the outer sheath and an inner lumen substantially coaxial to the outer sheath and incorporated into the flexible tubular shaft.

Abstract: This disclosure relates to shape memory alloys which have been subjected to a thermal and mechanical treatment to increase the austenite start temperature As?As? such that the shape memory alloy is martensitic at body temperature and when subsequently subjected to a controlled deformation, the shape memory alloy preferentially reverts to the parent phase. One application for this disclosure is a stent for use in a lumen in a human or animal body having a generally tubular body formed from a shape memory alloy which has been subjected to a thermal and mechanical treatment so it deforms as martensite until a critical expansion diameter is reached at which point the tubular body rapidly reverts to the parent phase with much higher mechanical properties. The shape memory alloy comprises Ni—Ti and a ternary element ranging from about 3 at. % to about 20 at. %. The ternary element is effectively insoluble in a Ni—Ti matrix.

Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.

Abstract: A shape memory alloy structure comprises at least one tubular member formed of shape memory material, each tubular member including a plurality of panels having side edges, wherein each tubular member is moveable between a radially contracted position and a radially extended position, and wherein the coupled side edges of adjacent panels of each tubular member form hinges for moving the structure between the contracted position and the extended position. Multiple layer tubular structures, methods for forming and fixtures for collapsing same are also disclosed.

Abstract: An implant for blood vessels, in particular to influence the flow of blood in the area of arteriovenous malformations. The implant has a wall comprising individual filaments combined so as to form a circular braiding, the circular braiding being positioned in elongated form and with a reduced diameter in an insertion catheter and expanding at the placement site thus adapting to the vessel diameter and increasing its braiding density.

Abstract: Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.

Abstract: The disclosure relates to a woven fabric for use in an implantable medical device. The woven fabric comprises shape memory element strands woven with textile strands. At least one of the shape memory element strands has at least one float of at least five textile strands between binding points.

Abstract: Methods and devices are disclosed for manipulating the airway, such as to treat obstructive sleep apnea. An implant is positioned within the body with respect to the airway. The spatial orientation of the airway is manipulated, directly or indirectly, to affect the configuration of the airway. In general, the implant is manipulated to displace the trachea in an inferior direction, resist superior displacement of the trachea and/or to alter the tracheal wall tension. The implant restrains the trachea in the manipulated configuration.

Abstract: The disclosure relates to a woven fabric for use in an implantable medical device. The woven fabric has shape memory element strands woven with textile strands. At least one of the shape memory element strands has at least one float of at least five textile strands between binding points.

Abstract: A stent graft extends in a flow lumen to span a defective portion of the flow lumen and seal the defective portion from further blood contact. The stent graft includes a pair of apertures, from which extensions project into the renal arteries to seal the passage of blood into the renal arteries from the abnormality. The apertures are larger than the opening of the renal arteries, such that the apertures need not be centered with the renal arteries to enable placement of the extensions. The aperture opening and side branch extensions contain hook and loop structures to provide a variably positionable seal of the aperture opening.

Abstract: A cardiovascular conduit system may comprise a connector. The connector may comprise a proximal end adapted to attach to a cardiovascular organ. The proximal end may comprise a first plurality of expandable members, and each member in the first plurality of expandable members may be deployable from a delivery position to a deployed position. The first plurality of expandable members may be dimensioned to deploy inside the cardiovascular organ to secure the connector to the cardiovascular organ. The connector may comprise a distal end adapted to attach to a conduit and an opening extending through the connector. Connectors for cardiovascular conduit systems may also include expandable stents. Connectors may be rotatably secured to a conduit, and the conduit may be reinforced. Methods for forming and using cardiovascular conduit systems are also disclosed.

Abstract: Methods of forming a structure for treating a vessel include providing a mandrel and braiding a plurality of filaments around the mandrel. The mandrel may include a strand having a longitudinal axis and a plurality of balls coupled to the strand along the longitudinal axis. Pairs of the plurality of balls may be spaced along the longitudinal axis. Braiding the plurality of filaments around the mandrel may include, during braiding, forming a plurality of bulbs around the plurality of balls and forming necks between pairs of the plurality of balls. The methods may include, after braiding the plurality of filaments, heat treating (e.g., shape setting) the plurality of filaments on the mandrel. Portions of the braided plurality of filaments may be secured to the mandrel, for example using bangles, wire, and/or adhesive.

Abstract: A hybrid prosthesis for deployment in a body vessel includes a tubular stent body comprising a wire comprising a shape memory alloy, where the tubular stent body has a self-expanding portion comprising a distal portion of the wire and a balloon-expandable portion comprising a proximal portion of the wire. The shape memory alloy comprises an Af of less than 37° C. in the self-expanding portion and an As of greater than 37° C. in the balloon-expandable portion.

Abstract: A flow diverter for implantation into a patient's vessel includes a distal annular support element and a proximal annular support element, the proximal and distal support elements supporting a longitudinally twisted diverter element. The flow diverter is designed to be disposed within a vessel and to impart a rotational or twisting motion to the flow of blood passing therethrough, thereby to reduce the pressure of blood at the center of the vessel. Such flow diversion can reduce the pressure of blood impinging upon an aneurysm at a bifurcation downstream of the vessel. The device can be particularly useful for the treatment of aneurysms occurring at the bifurcation between the basilar artery and the posterior cerebral arteries.

Abstract: A method of removing slag formed during laser cutting a hypotube may include flowing cooling gas into a laser nozzle, directing flow of the cooling gas onto an external surface of the hypotube, and injecting cooling fluid into an inner lumen of the hypotube at a velocity. Flowing the cooling gas and injecting the cooling fluid may at least partially remove slag from the external surface of the hypotube.

Abstract: Vasculature closure devices, and systems and methods for their use, are provided. In one embodiment, the vasculature closure device includes an expandable support frame deployable within a vessel and a sealing membrane at least partially supported by the expandable support frame. Upon expanding the support frame, the vasculature closure device is configured to intraluminally position the sealing membrane against a puncture site existing in a vessel wall.

Abstract: A self-expanding braided stent includes at least a distal radial expansion ring added to a distal end of the stent body to increase a radial expansion force of the self-expanding braided stent in deployment of the stent, and to facilitate advancement of the stent through a delivery sheath by a core advancement wire. A proximal radial expansion ring is optionally added to a proximal end of the stent body to allow the stent to be recaptured following partial deployment by retraction of the core advancement wire, prior to full deployment of a proximal portion of the stent body.

Abstract: A device for obtaining selective rigidity with respect to a patient is provided. The device includes a scaffold that is arranged to be flexible when in a first relaxed configuration, wherein the scaffold is configured to become substantially more rigid when a suction force is applied thereto. The scaffold comprises first and second opposing outer flexible layers that are sealed together to form a plurality of elongate pockets therein, and an expanded structure disposed within the plurality of elongate pockets and in communication with a vacuum port that receives the suction force.

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.

Abstract: An intra-vascular aneurysm-treatment stent and a method for lowering pressure within an aneurysm bubble in a blood vessel. A stent coil is insertable into a blood vessel, the coil made of a material sufficiently flexible to move around curves, loops, and corners in the blood vessel. Selected portions of the stent coil, in cross-section, have substantially convex outer surfaces, and either substantially flat, or substantially concave, inner surfaces, plus upstream leading edges and downstream trailing edges. The stent coil is positioned in the blood vessel with selected stent coil portions proximate an opening into either a saccular aneurysm or a fusiform aneurysm. Blood in the lumen of the blood vessel flows past the leading edges and both over the convex outer surfaces, and under the either flat or concave inner surfaces. A portion of the blood inside the aneurysm becomes entrained with the blood flowing over the outer surfaces.

Abstract: Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Abstract: Articles made of shape memory alloys having improved fatigue performance and to methods of treating articles formed from shape memory alloy materials by pre-straining the articles (or desired portions of the articles) in a controlled manner so that the resultant articles exhibit improved fatigue performance. The shape memory articles are preferably medical devices, more preferably implantable medical devices. They are most preferably devices of nitinol shape memory alloy, most particularly that is superelastic at normal body temperature. The pre-straining method of the present invention as performed on such articles includes the controlled introduction of non-recoverable tensile strains greater than about 0.20% at the surface of a desired portion of a shape memory alloy article. Controlled pre-straining operations are performed on the shape-set nitinol metal to achieve non-recoverable tensile strain greater than about 0.20% at or near the surface of selected regions in the nitinol metal article.

Abstract: A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

Abstract: Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measureable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Abstract: Intravascular cardiac restraining implants designed for treatment of heart disease and heart failure and methods for their use. The disclosed implants can be used to reshape or reinforce a diseased, weakened or distended portion of a patient's heart to counteract heart disease and heart damage. An intravascular cardiac restraining implant may include a first tissue anchor configured for implantation in a first region of a coronary vein, a second tissue anchor configured for implantation in a second region of the coronary vein, and at least one elongate member coupled to the first tissue anchor and the second tissue anchor. In one embodiment, the at least one elongate member may be a spring or a similar device configured for biasing the first and second tissue anchors toward one another, thus reshaping or reinforcing a diseased, weakened or distended portion of a patient's heart.