Coating Patents (Class 623/1.46)
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Patent number: 8992603Abstract: The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.Type: GrantFiled: October 2, 2012Date of Patent: March 31, 2015Assignees: Nanocopoeia, Inc., Louisiana State University Health Sciences Center Office of ResearchInventors: Tammy R. Dugas, Alok Khandelwal, James John Kleinedler, John Devlin Foley
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Patent number: 8992471Abstract: The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.Type: GrantFiled: November 5, 2008Date of Patent: March 31, 2015Assignees: Nanocopoeia, Inc., Louisiana State University Health Sciences Center Office of ResearchInventors: Tammy R. Dugas, Alok Khandelwal, James John Kleinedler, III, John Devlin Foley
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Patent number: 8986775Abstract: A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. The loading of a beneficial agent in a paste form also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.Type: GrantFiled: April 27, 2011Date of Patent: March 24, 2015Assignee: Innovational Holdings LLCInventors: John F. Shanley, Stephen Hunter Diaz, Theodore L. Parker
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Patent number: 8980364Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.Type: GrantFiled: January 14, 2014Date of Patent: March 17, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Yung-Ming Chen, Jason Van Sciver, Syed F. A. Hossainy, Stephen D. Pacetti
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Patent number: 8979921Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally polylactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.Type: GrantFiled: October 14, 2008Date of Patent: March 17, 2015Assignee: Tepha, Inc.Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams
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Patent number: 8974522Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.Type: GrantFiled: March 25, 2011Date of Patent: March 10, 2015Assignee: Cook Medical Technologies LLCInventors: Brian L. Bates, Anthony O. Ragheb, Joseph M. Stewart, IV, William J. Bourdeau, Brian D. Choules, James D. Purdy, Neal E. Fearnot
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Patent number: 8974520Abstract: The invention relates to a method for producing a bioactive surface on the balloon (3) of a balloon catheter (1). According to said method, the surface of the balloon (3) is at least partially wetted with a first solution of an active substance (8) and the section of the surface of the balloon (3) wetted with the first solution of an active substance (8) is then wetted with a second, saturated solution of the active substance (28). The invention further relates to a balloon (3) of a balloon catheter (1) the surface of which is at least partially coated with an active substance (11), the coating (11) being homogeneous and brittle in the entire coated region.Type: GrantFiled: July 21, 2009Date of Patent: March 10, 2015Inventor: Alexander Rübben
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Patent number: 8968765Abstract: The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.Type: GrantFiled: August 27, 2012Date of Patent: March 3, 2015Assignee: Industrial Technology Research InstituteInventors: Jui-Hsiang Chen, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-wei Hong, Chao-Chen Tien
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Patent number: 8968392Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.Type: GrantFiled: July 30, 2012Date of Patent: March 3, 2015Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo IwataInventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Patent number: 8961591Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.Type: GrantFiled: July 17, 2009Date of Patent: February 24, 2015Assignee: Tepha, Inc.Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams
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Patent number: 8961589Abstract: The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.Type: GrantFiled: August 1, 2007Date of Patent: February 24, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Lothar W. Kleiner, John Stankus, Nam D. Pham, Michael H. Ngo, Bozena Zofia Maslanka, Syed Faiyaz Ahmed Hossainy, Mikael Trollsas, Yiwen Tang
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Patent number: 8961592Abstract: At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.Type: GrantFiled: April 14, 2014Date of Patent: February 24, 2015Assignee: Biotronik AGInventors: Alexander Borck, Matthias Gratz, Horst Kessler, Michael Joner, Florian Rechenmacher, Stefanie Neubauer
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Patent number: 8956403Abstract: A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.Type: GrantFiled: September 21, 2011Date of Patent: February 17, 2015Assignee: Boston Scientific SciMed, Inc.Inventors: Daniel J. Gregorich, Michael P. Meyer, Jonathan S. Stinson
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Patent number: 8940039Abstract: A vascular prosthesis includes a prosthesis wall whose outer surface has at least one reinforcing means, the surface of the prosthesis wall and the surface of the at least one reinforcer being coated, at least in part, with an antimicrobial layer.Type: GrantFiled: September 26, 2008Date of Patent: January 27, 2015Assignee: Aesculap AGInventors: Helmut Goldmann, Dennis Langanke
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Patent number: 8936826Abstract: A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer.Type: GrantFiled: August 22, 2011Date of Patent: January 20, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Kevin Jow, Daniel A. Castro
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Patent number: 8932346Abstract: An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.Type: GrantFiled: April 23, 2009Date of Patent: January 13, 2015Assignee: Boston Scientific Scimed, Inc.Inventors: Michael Kuehling, Dominique Seidel, Torsten Scheuermann, Jan Weber
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Patent number: 8932347Abstract: Implantable materials having engineered surfaces and method of making same comprising geometric features on at least one surface of the material having at least one of chemical, physiochemical and electrochemical activity different than regions of the at least one surface without the features.Type: GrantFiled: August 13, 2012Date of Patent: January 13, 2015Assignee: Advanced Bio Prosthetic Surfaces, Ltd.Inventors: Animesh Choubey, Julio C. Palmaz
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Patent number: 8932345Abstract: Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device.Type: GrantFiled: February 4, 2008Date of Patent: January 13, 2015Assignee: Cook Medical Technologies LLCInventors: William F. Moore, Gary Bradford Shirley
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Patent number: 8927049Abstract: An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.Type: GrantFiled: August 11, 2010Date of Patent: January 6, 2015Inventors: Vipul Dave, Robert Falotico, Chengxue Li, Thai M. Nguyen, Theodore L. Parker, Jonathon Z. Zhao
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Patent number: 8920491Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating.Type: GrantFiled: April 17, 2009Date of Patent: December 30, 2014Assignee: Boston Scientific SciMed, Inc.Inventors: Aiden Flanagan, John Kilcooley, Tim O'Connor, Barry O'Brien, Dominique Seidel, Michael Kuehling, Torsten Scheuermann, Jan Weber
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Patent number: 8911857Abstract: The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel.Type: GrantFiled: January 31, 2012Date of Patent: December 16, 2014Assignee: Axetis AGInventor: Carlo Civelli
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Publication number: 20140364937Abstract: The invention relates to a structure having fibres which are adhesively bonded to one another in locations and have a permeability for air of between 0.5 ml/min*cm2 and 1.5 ml/min*cm2, wherein said structure has an at least one-sided coating which reduces the permeability of the structure to below 0.2 ml/min*cm2.Type: ApplicationFiled: December 19, 2012Publication date: December 11, 2014Inventors: Christoph Classen, Swen Franzen, Harrie Van Baars, Wolfgang Witt, Andreas Henseler, Frank Willems
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Patent number: 8906364Abstract: The present invention provides compositions for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt thereof. The invention further provides methods for preparing medical devices with such compositions.Type: GrantFiled: January 11, 2006Date of Patent: December 9, 2014Assignee: Kane Biotech Inc.Inventor: Srinivasa Madhyastha
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Patent number: 8900291Abstract: [Object] To provide a medical instrument capable of more effectively inhibiting a cracking and separation than conventional ones. [Solution Means] A stent comprising a substrate layer 10 of which at least the surface is composed of a metal material, a carbon compound layer 12 that is formed so as to coat the surface of the substrate layer 10 and that contains at least one metal element, a first DLC layer 14 that is formed so as to coat the surface of the carbon compound layer 12 and that is free of fluorine, and a second DLC layer 16 that is formed so as to coat the surface of the first DLC layer 14 and that contains fluorine. The stent being constituted to satisfy the relationship defined by the expression of “A1>A2>A3”, wherein A1 is a surface free energy of the carbon compound layer 12, A2 is a surface free energy of the first DLC layer 14, and A3 is a surface free energy of the second DLC layer 16.Type: GrantFiled: August 12, 2010Date of Patent: December 2, 2014Assignee: Kawasumi Laboratories, Inc.Inventors: Tetsuya Suzuki, Kazunori Murakami
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Patent number: 8894699Abstract: Methods and apparatus for anastomosis of a lumen according to various aspects of the present invention operate in conjunction with an impermeable stent. The impermeable stent may comprise a scaffold and, if needed, a sealant, such as a membrane and/or adhesive. In one embodiment, the scaffold, membrane and/or adhesive comprise biocompatible materials suitable for bio-absorption and/or degradation.Type: GrantFiled: April 7, 2008Date of Patent: November 25, 2014Assignee: Dr. Kelley Cancer FoundationInventor: Jill Kelley
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Patent number: 8888684Abstract: A medical device, for example, an endoscope or catheter, includes local drug delivery capabilities for selectively delivering at least one drug in vivo. The local drug delivery may occur as the medical device is advanced through tortuous passageways of the patient's body or may occur after the medical device has reached its targeted destination. The medical device includes a drug agent, for example, carried in or on a hydrophilic or hydrogel coating disposed on the outside thereof. When the hydrogel or drug agent receives an appropriate signal, e.g., solution containing a triggering agent or triggering condition, e.g., heat or light, the hydrogel contracts or expands to squeeze out the drug from hydrogel. If electric current is provided as the signal, and the drug agent is charged, the drug agent is released by electrophoretic forces.Type: GrantFiled: March 27, 2006Date of Patent: November 18, 2014Assignee: Boston Scientific Scimed, Inc.Inventors: Lucien A. Couvillon, Jr., Michael S. Banik, Samuel Sheng-Ping Zhong
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Patent number: 8888842Abstract: The invention relates to an implant consisting of a metallic magnesium alloy that can be resorbed by the body, said metallic material being a magnesium alloy consisting of at least 96% w/w of magnesium, at least 1% w/w of manganese and at least 0.5% w/w of at least one metal of the rare earth group.Type: GrantFiled: June 21, 2010Date of Patent: November 18, 2014Assignee: Qualimed Innovative Medizin-Produkte GmbHInventor: Manfred Gulcher
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Patent number: 8876890Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.Type: GrantFiled: June 24, 2013Date of Patent: November 4, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Bin Huang
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Patent number: 8871292Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.Type: GrantFiled: July 24, 2012Date of Patent: October 28, 2014Assignee: Biosensors International Group, Ltd.Inventors: Douglas R. Savage, Ronald E. Betts
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Medical devices and coatings therefore comprising biodegradable polymers with enhanced functionality
Patent number: 8871238Abstract: Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide optimum bioactive agent elution rates as well as degradation rates. Also provided are methods for making medical devices and medical device coatings using the biodegradable polymers.Type: GrantFiled: August 9, 2006Date of Patent: October 28, 2014Assignee: Medtronic Vascular, Inc.Inventors: Peiwen Cheng, Mingfei Chen, Kishore Udipi -
Patent number: 8864821Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.Type: GrantFiled: November 24, 2009Date of Patent: October 21, 2014Assignee: VisEn Medical, Inc.Inventors: Farouc Jaffer, Milind Rajopadhye
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Patent number: 8864816Abstract: An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.Type: GrantFiled: March 14, 2012Date of Patent: October 21, 2014Assignee: Boston Scientific SciMed, Inc.Inventors: Jan Weber, Aiden Flanagan
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Patent number: 8864820Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The coating compensates for regions of higher stress and resulting strain due to the geometry of the device. Certain embodiments may include a nonuniform coating on the device in which a strain on the nonuniform coating is less than a strain on a uniform coating when the device is placed under an applied stress during use. Other embodiments may include a coating with a greater resistance to strain on higher strain regions of the device.Type: GrantFiled: August 16, 2013Date of Patent: October 21, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Philip Foreman, Charles W. Snyder, Gregg Teaby, Eric Penn
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Publication number: 20140309726Abstract: Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some examples, a vascular graft includes a biodegradable scaffold including a biodegradable polyester tubular core, a biodegradable polyester electrospun outer sheath surrounding the biodegradable polyester tubular core and/or a thromboresistant agent, such as heparin, coating the biodegradable scaffold. The disclosed vascular grafts can be used for forming a blood vessel of less than 6 mm, including, but not limited to a coronary or peripheral arterial.Type: ApplicationFiled: December 21, 2012Publication date: October 16, 2014Applicant: University of Pittsburgh - Of The Commonwealth System of Higher EducationInventor: Yadong Wang
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Patent number: 8858618Abstract: Provided is a stent wherein the water-swellable polymer fine particles applied thereto rarely peel off even when the stent is deformed or when the water-swellable polymer fine particles are swollen. A stent wherein a plurality of water-swellable polymer fine particles are chemically fixed on the stent surface in a dispersed state is provided.Type: GrantFiled: September 6, 2010Date of Patent: October 14, 2014Assignee: Terumo Kabushiki KaishaInventors: Takao Anzai, Yosuke Kuruma
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Publication number: 20140296968Abstract: A stent for implantation in a vessel is described that is radially expandable, and when expanded in a vessel, lies against the inner wall thereof. The stent is provided with a coating applied to its surface and composed of a bioresorbable oligomeric binding agent and of an active substance (FIG. 1).Type: ApplicationFiled: July 5, 2012Publication date: October 2, 2014Applicant: Translumina GmbHInventors: Christian Bader, Boris Behnisch
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Publication number: 20140294912Abstract: Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Stephen D. Pacetti, Syed Faiyaz Ahmed Hossainy, David C. Gale
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Patent number: 8845751Abstract: An endoprosthesis component and a method for producing an endoprosthesis component is disclosed. The endoprosthesis component comprises a body predefining the shape of the endoprosthesis component. On surface portions with which the endoprosthesis component in the implanted state is in contact with human tissue, the body is covered with an outer layer which comprises a nitride, an oxynitride or an oxide based on a refractory metal and which contains silver and/or copper. An intermediate layer is arranged between the outer layer and the body in such a way that parts of the intermediate layer are accessible from the outside. The endoprosthesis component enables generation of a long-term antimicrobial action with the outer layer and, in addition, action on the surrounding tissue from the intermediate layer.Type: GrantFiled: September 22, 2008Date of Patent: September 30, 2014Assignee: Waldemar Link GmbH & Co. KGInventors: Helmut D. Link, Roger Thull
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Publication number: 20140271771Abstract: Implantable object, comprising a layer, comprising a copolymer that contains an aptamer, wherein bonds in the copolymer can be broken in accordance with a binding event at the aptamer, such that the copolymer degrades.Type: ApplicationFiled: March 4, 2014Publication date: September 18, 2014Applicant: Biotronik AGInventors: Jens Ulmer, Michael Diebold
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Patent number: 8834338Abstract: The present invention discloses a method of selectively providing radiation dosimetry to a subject in need of such treatment. The radiation is applied by an implant comprising a body member and 117mSn electroplated at selected locations of the body member, emitting conversion electrons absorbed immediately adjacent selected locations while not affecting surrounding tissue outside of the immediately adjacent area.Type: GrantFiled: June 6, 2007Date of Patent: September 16, 2014Assignee: SnIP Holdings, Inc.Inventors: Suresh Srivastava, Gilbert R. Gonzales, Roger W. Howell, Wesley E. Bolch, Radoslav Adzic
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Patent number: 8821568Abstract: An implant to be used as medical or dental implant, comprising a metallic or polymeric base which is covered by the vitamin D precursor cholecalciferol. The implant can be obtained by direct covering of the polymeric or metallic base with a solution comprising cholecalciferol or also covering the base with the 7-dehydrocholesterol (7-DHC), and subsequently irradiated with UV light to induce the formation of cholecalciferol. Optionally, the coating of the implant may include an antioxidant such as vitamin E. This implant enhances osseointegration in compromised patients by means of the endogenous synthesis and activity of vitamin D in hard and mineralized tissue regeneration. Furthermore, a method to obtain these implants which comprises coating the surface of the implant directly with cholecalciferol or with a specific concentration of 7-DHC and irradiated with UV light to induce the formation of cholecalciferol.Type: GrantFiled: July 26, 2012Date of Patent: September 2, 2014Assignee: Numat Biomedical S.L.Inventors: Ståle Petter Lyngstadaas, Marta Monjo, Christiane Petzold, Jan Erik Ellingsen
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Patent number: 8801778Abstract: An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CFx layer that is nonpolymerized and has an F/C ratio in the range of 0.5 to 1.5.Type: GrantFiled: February 4, 2013Date of Patent: August 12, 2014Assignee: BIOTRONIK VI Patent AGInventors: Baerbel Becher, Carsten Momma, Daniel Lootz, Antje Quade, Andreas Ohl, Karsten Schroeder
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Publication number: 20140222134Abstract: At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.Type: ApplicationFiled: April 14, 2014Publication date: August 7, 2014Applicant: BIOTRONIK AGInventors: Alexander Borck, Matthias Gratz, Horst Kessler, Michael Joner, Florian Rechenmacher, Stefanie Neubauer
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Patent number: 8790392Abstract: An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes.Type: GrantFiled: May 25, 2011Date of Patent: July 29, 2014Assignee: Boston Scientific Scimed, Inc.Inventor: Michael Kuehling
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Patent number: 8790393Abstract: The present disclosure is directed to tantalum-alloy products, implantable medical devices that incorporate tantalum-alloy products such as stents or other implantable medical devices, methods of making and/or processing the tantalum-alloy products and implantable medical devices, and methods of using the implantable medical devices. In an embodiment, a stent includes a stent body having a plurality of struts. At least a portion of the stent body is made from a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % (“wt %”) to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof, such as yield strength, ultimate tensile strength, or ductility.Type: GrantFiled: October 12, 2011Date of Patent: July 29, 2014Assignee: Abbott Cardiovascular Systems, Inc.Inventors: Rainer Bregulla, Randolf von Oepen, Pamela A Kramer-Brown, Austin M Leach
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Patent number: 8784465Abstract: A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.Type: GrantFiled: November 5, 2010Date of Patent: July 22, 2014Assignees: Boston Scientific Scimed, Inc., University of ConnecticutInventors: Ronald A. Sahatjian, Francisca Tan, Patrick T. Mather, Changdeng Liu, Cheryl J. Campo
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Patent number: 8784862Abstract: The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.Type: GrantFiled: June 30, 2010Date of Patent: July 22, 2014Assignee: Hemoteq AGInventors: Roland Horres, Marita Katharina Linssen, Michael Hoffmann, Erika Hoffmann, Donate DiBiase, Volker Faust
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Patent number: 8778014Abstract: A medical assembly is disclosed comprises a stent and a catheter having a balloon, wherein the coefficient of friction and/or the adhesion at the stent/balloon interface are reduced.Type: GrantFiled: March 31, 2004Date of Patent: July 15, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen Robert Dugan, Jessica Reneé DesNoyer, Stephen D. Pacetti, Bozena Maslanka
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Patent number: 8778015Abstract: A medical device with metal parts to be introduced into animal or human bodies is rendered visible during RMN imaging by covering the exterior surface of the metal parts with a layer comprising Nickel monoxide. When placed within the electromagnetic field generated by a NMR apparatus, the layer reduces disturbances induced in this field in the vicinity of the metal part. This improvement is chiefly related to endoprostheses for subjects or patients who will be submitted to NMR imaging. In particular, the invention is aimed at luminal endoprostheses comprising a metal frame, as stents.Type: GrantFiled: March 3, 2006Date of Patent: July 15, 2014Inventors: Noureddine Frid, Patricia Gruffaz
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Patent number: 8771343Abstract: Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.Type: GrantFiled: June 15, 2007Date of Patent: July 8, 2014Assignee: Boston Scientific SciMed, Inc.Inventors: Jan Weber, Liliana Atanasoska, James Lee Shippy, III, Edward E. Parsonage