Coating Patents (Class 623/1.46)
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Patent number: 8303651Abstract: A stent for delivery of a therapeutic agent is disclosed. The stent includes a polymer coating for reducing the rate of release of the therapeutic agent. The polymer has a crystalline structure wherein the polymer is capable of significantly maintaining the crystalline lattice structure while the therapeutic agent is released from the stent such that the aqueous environment to which the stent is exposed subsequent to the implantation of the stent does not significantly convert the crystalline lattice structure of the polymer to an amorphous structure.Type: GrantFiled: September 7, 2001Date of Patent: November 6, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Patent number: 8303650Abstract: Disclosed herein is a biodegradable prosthesis that includes a first end, a second end, and an elongate tubular body with a lumen therethrough. The prosthesis has a first outer layer with a drug delivery element that may include polyphosphoester microspheres. The prosthesis also can have a second layer comprising a set of flexible interbraided bioabsorbable filaments. Also, the prosthesis can have a third inner layer comprising a porous thermoplastic material.Type: GrantFiled: January 10, 2008Date of Patent: November 6, 2012Assignee: Telesis Research, LLCInventor: Mehrdad M. Shokoohi
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Patent number: 8293318Abstract: Methods for modulating the release rate of a drug coated stent are disclosed.Type: GrantFiled: August 29, 2007Date of Patent: October 23, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Shaw Ling Hsu, Ni Ding, Yiwen Tang, Fuh-Wei Tang, Lothar Walter Kleiner, Syed Faiyaz Ahmed Hossainy
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Patent number: 8293260Abstract: Implantable medical devices with elastomeric copolymer coatings are disclosed.Type: GrantFiled: June 5, 2007Date of Patent: October 23, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventor: Yunbing Wang
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Patent number: 8287937Abstract: A coating having a smooth orange peel morphology is formed on an adluminal surface of a stent, concurrently with the formation of a coating having a rough rice grain morphology on an abluminal surface of the stent. During the formation of the two coatings, a mandrel is placed adjacent to the adluminal surface of the stent but does not generally contact the adluminal surface.Type: GrantFiled: April 24, 2009Date of Patent: October 16, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Rajesh Radhakrishnan, Scott R. Schewe, Victor Schoenle
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Patent number: 8282979Abstract: An apparatus for coating medical devices at the point of care with a polymer and/or therapeutic agent comprising an environmentally controlled device coating chamber in which the device may be delivered by the manufacturer as the device packaging, or the device may be placed into the chamber at the point of care. The environmentally controlled chamber can provide a sterile enclosure in which the polymer and/or a therapeutic agent can be applied to an uncoated or previously coated device and converted to another form (such as a liquid to a film or gel) if desired, under controlled and reproducible conditions. The environmentally controlled chamber can accommodate and provide for coating the device by immersion, spray and other methods of covering the device surface with a liquid or powder. The chamber can provide for energy sources, both internally, such as heat produced by film heaters, and externally, such as UV light or microwave passing through the enclosure.Type: GrantFiled: August 3, 2010Date of Patent: October 9, 2012Inventors: Marian L. Larson, Eugene A. Larson
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Patent number: 8277926Abstract: A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a lower degree of hydration than the first polymer.Type: GrantFiled: January 18, 2008Date of Patent: October 2, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen D. Pacetti, Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Thierry Glauser
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Patent number: 8277833Abstract: According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.Type: GrantFiled: June 23, 2009Date of Patent: October 2, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Liliana Atanasoska, James Lee Shippy, III, Benjamin Arcand, Robert W. Warner
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Publication number: 20120245677Abstract: The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.Type: ApplicationFiled: March 22, 2012Publication date: September 27, 2012Applicant: Palmetto Pharmaceuticals LLCInventor: Wayne H. Kaesemeyer
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Patent number: 8273402Abstract: A method for manufacturing a drug carrying stent includes applying at least a first therapeutic agent to at least an outer portion of a stent framework and applying a first magnesium coating on at least a first portion of the applied first therapeutic agent.Type: GrantFiled: February 26, 2007Date of Patent: September 25, 2012Assignee: Medtronic Vascular, Inc.Inventors: Eric Yu, James Mitchell
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Publication number: 20120239140Abstract: An embodiment of the present invention relates to a medical product coated with a polymer layer, which comprises an inhibitor of the TRPC-3 ion channel underneath, in, and/or on the biostable or biodegradable polymer layer.Type: ApplicationFiled: March 15, 2012Publication date: September 20, 2012Inventors: Eric Wittchow, Klaus Groschner, Marlen Braune
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Publication number: 20120239139Abstract: Implants and methods of making same are provided for treatment or prophylaxis of coronary or peripheral vascular constrictions or vascular occlusions, and particularly, stenoses or restenoses, that comprise FK506 in chemically covalently bound, non-covalently bound or physically immobilized form.Type: ApplicationFiled: May 25, 2012Publication date: September 20, 2012Applicants: ASTELLAS PHARMA INC., ABBOTT LABORATORIES VASCULAR ENTREPRISES LTD.Inventors: Stephan Wnendt, Randolf Von Oepen, Bernd Kuttler, Gerhard Lang, Guenter Lorenz, Axel Grandt
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Patent number: 8267992Abstract: A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.Type: GrantFiled: March 2, 2010Date of Patent: September 18, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Liliana Atanasoska, James Lee Shippy, III, Tom Holman, Michael S. Arney, Victor Schoenle, Frank Genovese, James Q. Feng, Aiden Flanagan, Jan Weber
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Patent number: 8263171Abstract: The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.Type: GrantFiled: July 10, 2008Date of Patent: September 11, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: John T. Clarke, Timothy O'Connor
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Patent number: 8263170Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.Type: GrantFiled: January 6, 2010Date of Patent: September 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Ni Ding, Christopher Buchko
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Patent number: 8257777Abstract: Methods and devices for coating a medical device, such as a stent, including the steps of coating the medical device with a photoresist polymeric coating, irradiating a portion of the medical device, optionally applying a post-exposure bake step, and removing all or a portion of the coating from the irradiated portion of the medical device, if a positive photoresist coating material is used, or from a portion of the medical device not exposed to the radiation, if a negative photoresist coating material is used. The photoresist polymeric coating may optionally include a drug.Type: GrantFiled: April 10, 2008Date of Patent: September 4, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Peter Edelman
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Patent number: 8257729Abstract: An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.Type: GrantFiled: December 10, 2008Date of Patent: September 4, 2012Assignees: Biotronik VI Patent AG, Universitaet Rostock, Universitaet GreifswaldInventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, Claus Harder, Bjoern Klocke, Heyo K. Kroemer, Werner Weitschies
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Patent number: 8252047Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating.Type: GrantFiled: February 8, 2011Date of Patent: August 28, 2012Assignee: Biosensors International Group, Ltd.Inventors: Douglas R. Savage, Ronald E. Betts
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Patent number: 8252048Abstract: A drug eluting stent comprising a multilayer tubular structure which includes at least one intermediate layer having reservoirs therein for deposition of a drug, the intermediate layer eluting drug in a lateral direction, and methods of making the same.Type: GrantFiled: March 19, 2008Date of Patent: August 28, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Scott R. Smith
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Patent number: 8252046Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: GrantFiled: December 15, 2009Date of Patent: August 28, 2012Assignee: Biosensors International Group, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Patent number: 8247019Abstract: The present invention provides an apparatus and a method for modifying a structure such as a medical device through the selective application of a coating. A coating sleeve may comprise an elastomeric wall that may be permeable or impermeable to a coating material and may be porous so as to allow for patterned coating of the device. The coating sleeve may contain surface protrusions that facilitate manipulation by providing sites for grasping and pulling. In operation the coating sleeve may be fitted on the device prior to application of a coating and removed subsequent to application of the coating.Type: GrantFiled: April 25, 2008Date of Patent: August 21, 2012Assignee: Harland Medical Systems, Inc.Inventors: Jonathan D. Anderson, Dale L. Anderson, Aaron J. Anderson
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Patent number: 8236048Abstract: A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.Type: GrantFiled: April 27, 2004Date of Patent: August 7, 2012Inventors: Robert Falotico, John Siekierka, Gerard H. Llanos, Gregory A. Kopia, Andrew J. Carter
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Publication number: 20120197387Abstract: A stent includes: a main body unit including a plurality of through holes and configured to have a net-like shape; and a coating unit filling the through holes of the main body unit and configured as a layer on the main body unit, wherein the main body unit has force of restitution to be restored to its original shape, and the coating unit includes a support unit for maintaining the shape of the main body unit by hampering the restoration of the main body unit and a blocking unit blocking the through holes of the main body unit to discriminate the interior and the exterior of the main body unit. The stent can be quickly expanded in a blood vascular system, or the like, after being inserted into the body in a surgical procedure, thus improving expansion (or extension) effect.Type: ApplicationFiled: January 18, 2012Publication date: August 2, 2012Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Kwang Koo JEE, Jun Hyun HAN
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Patent number: 8231962Abstract: A coating for an implantable medical device is provided comprising a first layer including a first polymer and a second layer including a second polymer. The second layer is disposed over at least a portion of the first layer. The second polymer has a lower degree of hydration than the first polymer.Type: GrantFiled: January 18, 2008Date of Patent: July 31, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen D. Pacetti, Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Thierry Glauser
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Patent number: 8231929Abstract: Methods for coating medical devices for implantation within a body vessel are provided comprising providing a cylindrical container, placing a medical device inside the cylindrical container, and applying a polymer in liquid form inside the container.Type: GrantFiled: October 23, 2007Date of Patent: July 31, 2012Assignee: Cook Medical Technologies LLCInventor: Jichao Sun
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Patent number: 8231980Abstract: A medical implant includes iridium oxide. The iridium oxide has a plurality of Ir—O ? bonds and a plurality of Ir?O ? bonds. The iridium oxide has a ratio of the Ir—O ? bonds to the Ir?O ? bonds that is greater than 1.3.Type: GrantFiled: December 3, 2009Date of Patent: July 31, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Liliana Atanasoska, Pankaj Gupta, Charles Deng
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Publication number: 20120185037Abstract: The invention relates to methods and apparatus for manufacturing implantable medical devices, such as intravascular stents, wherein the medical device has a surface treated to promote the migration of endothelial cells onto the surface of the medical device. In particular, the surface of the medical device has at least one groove formed therein, the at least one groove may have a drug-eluting polymer disposed therein or a drug-eluting polymer coating may be provided on the surface of the medical device and grooves formed in the drug eluting polymer coating.Type: ApplicationFiled: August 19, 2011Publication date: July 19, 2012Applicant: Palmaz Scientific, Inc.Inventor: Julio C. Palmaz
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Patent number: 8221783Abstract: Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.Type: GrantFiled: September 10, 2008Date of Patent: July 17, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Michael N. Helmus, Yixin Xu, Barron W. Tenney, Paul L. Valint, Shrirang V. Ranade
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Patent number: 8216632Abstract: A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an a luminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.Type: GrantFiled: November 2, 2007Date of Patent: July 10, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Victor Schoenle, Scott R. Schewe, Rajesh Radhakrishnan
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Publication number: 20120172976Abstract: The present disclosure pertains to stents having a coating applied thereto, wherein the coating comprises a biocompatible polymer/drug mixture, as well as devices comprising a metallic stent, a biocompatible polymeric carrier and a drug.Type: ApplicationFiled: March 15, 2012Publication date: July 5, 2012Applicant: CORDIS CORPORATIONInventors: Carol Wright, Gerard H. Llanos, Ronald Rakos, Kristen King
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Publication number: 20120171260Abstract: Stents and delivery systems with reduced chemical degradation and methods of sterilizing the same are disclosed.Type: ApplicationFiled: March 12, 2012Publication date: July 5, 2012Applicant: Abbott Cardiovascular Systems Inc.Inventors: Bin Huang, Lothar W. Kleiner, John Stankus
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Patent number: 8211457Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.Type: GrantFiled: March 12, 2010Date of Patent: July 3, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
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Patent number: 8211168Abstract: This invention is directed to graft materials for implanting, transplanting, replacing, or repairing a part of a patient and to methods of making the graft materials. The present invention is also directed to stent grafts and endoluminal prostheses formed of the graft materials. More specifically, the present invention is a graft material which includes porous polymeric sheet, extracellular matrix material (ECM) disposed on at least a portion of the porous polymeric sheet and at least one polymer layer disposed on at least a portion of the ECM. The ECM may be in a gel form. The polymeric sheet and the polymer layer may be made from foam material and may comprise a polyurethane urea and a surface modifying agent such as siloxane.Type: GrantFiled: February 20, 2007Date of Patent: July 3, 2012Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: James D. Purdy, David D. Grewe, Kurt Dierking, Lal Ninan, Jichao Sun
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Patent number: 8206436Abstract: The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected.Type: GrantFiled: November 11, 2009Date of Patent: June 26, 2012Assignee: Merit Medical Systems, Inc.Inventors: Eric K. Mangiardi, Jason M. Reynolds, Ulf R. Borg
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Patent number: 8206733Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.Type: GrantFiled: March 12, 2010Date of Patent: June 26, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
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Publication number: 20120158127Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z?CH2COO— where z? is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R? is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.Type: ApplicationFiled: February 22, 2012Publication date: June 21, 2012Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Patent number: 8202528Abstract: Implantable medical devices with elastomeric block copolymer coatings are disclosed.Type: GrantFiled: June 5, 2007Date of Patent: June 19, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Yunbing Wang, Daniel Castro
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Publication number: 20120150277Abstract: The present invention relates to stent structures having improved migration resistance. In particular, the invention relates to mesh stents, such as braided or twisted stent designs, where at least a portion of the stent is folded back over itself to form a multi-layered stent device. Such multi-layered portions provide for migration resistance, among other advantages.Type: ApplicationFiled: February 14, 2012Publication date: June 14, 2012Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Mark Wood, Paul Norton, William Bertolino, F. Anthony Headley, JR.
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Publication number: 20120150285Abstract: Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 ?m to 50 ?m, and thickness from 10 ?m to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 ?m to 50 ?m, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.Type: ApplicationFiled: June 15, 2011Publication date: June 14, 2012Inventors: Ryan Cahil, Kai Guo, David P. Martin, Said Rizk
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Publication number: 20120150286Abstract: Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed.Type: ApplicationFiled: February 14, 2012Publication date: June 14, 2012Applicant: Boston Scientific SciMed, Inc.Inventors: Jan Weber, Liliana Atanasoska, Scott Schewe
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Publication number: 20120150281Abstract: The invention relates to an implant having a base body made of a biocorrodible material. A surface of the implant has a coating at least in some regions, wherein the coating comprises a tissue adhesive.Type: ApplicationFiled: December 6, 2011Publication date: June 14, 2012Inventors: Bjoern Klocke, Matthias Gratz
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Publication number: 20120143318Abstract: The invention relates to an implant consisting of a metallic magnesium alloy that can be resorbed by the body, said metallic material being a magnesium alloy consisting of at least 96% w/w of magnesium, at least 1% w/w of manganese and at least 0.5% w/w of at least one metal of the rare earth group.Type: ApplicationFiled: June 21, 2010Publication date: June 7, 2012Inventor: Manfred Gulcher
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Patent number: 8187321Abstract: An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.Type: GrantFiled: September 7, 2005Date of Patent: May 29, 2012Assignee: Innovational Holdings, LLCInventors: John F. Shanley, Neal L. Eigler, Kinam Park, Elazer R. Edelman
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Patent number: 8187322Abstract: A drug eluting stent comprising a multilayer tubular structure which includes at least one intermediate layer having reservoirs therein for deposition of a drug, the intermediate layer eluting drug in a lateral direction, and methods of making the same.Type: GrantFiled: March 14, 2011Date of Patent: May 29, 2012Assignee: Boston Scientific Scimed, Inc.Inventor: Scott R. Smith
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Publication number: 20120130483Abstract: A tubular implant that replaces natural blood vessels includes a prefabricated vascular prosthesis with an internal surface, an external surface and a wall, wherein the internal and/or external surface of the prefabricated vascular prosthesis has a polyurethane coating.Type: ApplicationFiled: March 18, 2010Publication date: May 24, 2012Applicant: AESCULAP AGInventors: Helmut Goldmann, Christof Merckle, Dietmar Probst, Dennis Langanke
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Publication number: 20120130482Abstract: The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel.Type: ApplicationFiled: January 31, 2012Publication date: May 24, 2012Applicant: AXETIS AGInventor: Carlo Civelli
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Patent number: 8182527Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In addition, various polymer combinations as well as other therapeutic agents may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.Type: GrantFiled: June 21, 2004Date of Patent: May 22, 2012Inventors: Gerard H. Llanos, Pallassana V. Narayanan, George Papandreou
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Publication number: 20120123514Abstract: Devices and methods are described for treating maladies such as atrial fibrillation. The devices and methods, in some implementations, include two rings separated by a helical winding. The rings and at least one helical winding provide mechanical pressure against an adjacent tissue, e.g., the tissue of a vessel, and the pressure works to inhibit the propagation of electrical signals along the vessel.Type: ApplicationFiled: December 13, 2011Publication date: May 17, 2012Applicant: MEDICAL DEVICE INNOVATIONS INC.Inventor: Christopher Gerard Kunis
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Publication number: 20120121658Abstract: At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.Type: ApplicationFiled: November 9, 2011Publication date: May 17, 2012Applicant: BIOTRONIK AGInventors: Alexander Borck, Matthias Gratz, Horst Kessler, Michael Joner, Florian Rechenmacher, Stefanie Neubauer
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Publication number: 20120116503Abstract: The invention relates to medical device systems that include a delivery instrument comprising a sheath having an abluminal surface and a luminal surface; a radially-expandable frame disposed at least partially within the sheath, the frame having an abluminal surface at least partially in contact with the luminal surface of the sheath, and a luminal surface defining a sub-stantially cylindrical lumen; and a fine powder coating disposed on at least one of the abluminal surface of the frame and the luminal surface of the sheath. The invention also relates to methods of manufacturing, loading, and delivering the coated medical devices.Type: ApplicationFiled: July 13, 2010Publication date: May 10, 2012Applicant: Med Institute, LLCInventors: David D. Grewe, Kenneth Haselby, Keith Milner