Coating Patents (Class 623/1.46)
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Patent number: 8105374Abstract: The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel.Type: GrantFiled: May 31, 2006Date of Patent: January 31, 2012Assignee: Axetis AGInventor: Carlo Civelli
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Patent number: 8100528Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.Type: GrantFiled: December 15, 2008Date of Patent: January 24, 2012Assignee: Bausch & Lomb IncorporatedInventors: Jeffrey G. Linhardt, Devon A. Shipp, Jay F. Kunzler, David Paul Vanderbilt
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Publication number: 20120004721Abstract: Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.Type: ApplicationFiled: July 1, 2011Publication date: January 5, 2012Inventors: Yunbing WANG, Daniel A. CASTRO, Stephen D. PACETTI
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Patent number: 8088160Abstract: The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth factor. The device can be coated with a biodegradable drug-eluting polymer that is impregnated with the inhibitor of smooth muscle cell proliferation and the growth factor. The device is useful for treating or preventing a vascular disease or disorder such as restenosis, by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention.Type: GrantFiled: June 2, 2009Date of Patent: January 3, 2012Assignee: Multi-Gene Vascular Systems Ltd. (“MGVS”)Inventor: Moshe Flugelman
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Publication number: 20110321181Abstract: An indwelling vascular device is constructed such that a vascular stenosis model can be controlled from the partial stenosis to the total occlusion. There is also described a vascular stenosis model of such non-human animal, and a method for making the same. The model can be used for diagnosis or therapy of a disease resulting from the stenosis or total occlusion in a blood vessel or further for the development of therapeutic approaches. The indwelling vascular device includes a device substrate containing a metal and/or metal compound which elutes toxic metal ions at least from a surface thereof and having a structure ensuring a vascular flow immediately after indwelling in a blood vessel, and a polymer coating layer formed on at least a metal and/or metal compound containing surface of the substrate.Type: ApplicationFiled: September 2, 2011Publication date: December 29, 2011Applicant: TERUMO KABUSHIKI KAISHAInventors: Kenichi SHIMURA, Taizou IWASAKI, Fumiaki IKENO
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Publication number: 20110319986Abstract: A method for producing an implant, particularly an intralumimal endoprosthesis, having a body, wherein the body comprises magnesium or a magnesium alloy. In order to control the degradation in a desired time window, such as between four weeks and six months, the following production method is carried out: a) preparing the implant body, b) applying a metallic coating onto at least a portion of the body surface, the primary constituent of the coating being at least one element of the group containing titanium and aluminum, c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution in order to produce a layer created by plasmachemical treatment by applying a mixed voltage generating the plasma to the body of the implant, wherein the mixed voltage has sufficient energy to temporarily ionize both the metallic coating and a subjacent region of the implant body. The invention further relates to an implant that can be obtained by such a method.Type: ApplicationFiled: June 20, 2011Publication date: December 29, 2011Applicant: BIOTRONIK AGInventors: Ullrich Bayer, Alexander Rzany
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Publication number: 20110319987Abstract: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.Type: ApplicationFiled: July 14, 2011Publication date: December 29, 2011Applicant: Arsenal MedicalInventors: Maria Palasis, Chang Cheng You, Daniel Concagh, Lee Core, Kicherl Ho, Upma Sharma, Greg Zugates
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Patent number: 8084076Abstract: A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent. Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.Type: GrantFiled: February 7, 2008Date of Patent: December 27, 2011Assignee: Sorin Biomedica Cardio S.R.L.Inventors: Andrea Grignani, Maria Curcio, Vincenzo Cassolaro
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Publication number: 20110313502Abstract: A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.Type: ApplicationFiled: August 31, 2011Publication date: December 22, 2011Applicant: Prescient Medical, Inc.Inventors: Juan Granada, Simon M. Furnish
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Patent number: 8080055Abstract: A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects.Type: GrantFiled: December 27, 2007Date of Patent: December 20, 2011Assignee: Boston Scientific SciMed, Inc.Inventors: Liliana Atanasoska, Jan Weber, Robert W. Warner
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Publication number: 20110307054Abstract: One example embodiment of the present invention relates to an implant with a coating or a cavity filling containing a nucleic acid, which i) can inhibit the expression of at least one representative of the Ras gene family by means of RNA interference; or ii) encodes for a nucleic acid that can inhibit the expression of at least one representative of the Ras gene family by means of RNA interference.Type: ApplicationFiled: December 3, 2010Publication date: December 15, 2011Inventors: Alexander Borck, Matthias Gratz
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Publication number: 20110307053Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device.Type: ApplicationFiled: July 7, 2011Publication date: December 15, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Bin Huang, John M. Capek, Houdin Dehnad
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Patent number: 8075612Abstract: Textile vascular prostheses having a coating include an absorbable polymer in the form of a three-armed polyester having terminal hydroxyl groups from hydroxy acids polymerized onto a central trifunctional hydroxy compound, the three arms being tetrapolymers of lactide, ?-caprolactone, trimethylene carbonate and glycolide. The polymer is composed of about 30 to about 45 mol % of lactide, about 20 to about 40 mol % of ?-caprolactone, about 10 to about 28 mol % of trimethylene carbonate and about 10 to about 25 mol % of glycolide.Type: GrantFiled: November 7, 2007Date of Patent: December 13, 2011Assignees: Aesculap AG, Poly-Med, Inc.Inventors: Helmut Goldmann, Christof Merckle, Shalaby W. Shalaby
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Publication number: 20110301695Abstract: Disclosed is a stent that allows rapid coverage of the stent's luminal surface with endothelial cells while eluting enough anti-restenosis drug from the stent's abluminal surface to eliminate restenosis. A delay in the release of the anti-restenosis drug from the abluminal surface of the stent struts is created by a drug-free biodegradable polymer that covers that abluminal surface of the stent The anti-restenosis drug being only on the abluminal surface of the stent and the release of that drug being delayed by the outer polymer covering of that abluminal surface allows endothelial cells to have unconstrained mitosis so that they quickly cover the stent's luminal surface. It is further conceived to cover the luminal surface of the stent with an anti-thrombogenic coating such as carbon to further encourage endothelial cell coverage while deterring the deposition of platelets.Type: ApplicationFiled: June 8, 2010Publication date: December 8, 2011Applicant: SVELTE MEDICAL SYSTEMS, INC.Inventor: ROBERT E. FISCHELL
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Publication number: 20110301697Abstract: The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.Type: ApplicationFiled: June 15, 2011Publication date: December 8, 2011Inventors: Erika Hoffmann, Michael Hoffmann, Roland Horres, Sabine Küsters
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Publication number: 20110301696Abstract: This application is directed to a device comprising a covering attached to the device. A process of making a device with a specific covering attached is also disclosed. The application further discloses a method for the treatment of perforations, fistulas, ruptures, dehiscence and aneurisms in luminal vessels and organs of a subject.Type: ApplicationFiled: May 31, 2011Publication date: December 8, 2011Inventor: Eric K. Mangiardi
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Patent number: 8071156Abstract: A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles.Type: GrantFiled: March 4, 2009Date of Patent: December 6, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Jan Weber, Torsten Scheuermann
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Patent number: 8070720Abstract: A method of manufacturing a drug delivery device includes forming a undercoat on an outer surface of a dipping mandrel, forming a tack coat on an outer surface of the undercoat, depositing granular particles on at least a portion of the tack coat, forming an overcoat on the formed tack coat, trapping the granular particles between the tack coat and the overcoat and removing an outermost portion of the overcoat to expose a portion of the granular particles. A system for treating a vascular condition includes a catheter having an inflation lumen, an elastomeric drug delivery device disposed on the catheter and in fluid communication with the inflation lumen, a plurality of expandable pores disposed within an outer layer of the elastomeric drug delivery device and at least one therapeutic agent disposed within at least a portion of the plurality of expandable pores.Type: GrantFiled: January 11, 2008Date of Patent: December 6, 2011Assignee: Medtronic Vascular, IncInventor: David Johnson
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Patent number: 8070797Abstract: The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.Type: GrantFiled: February 27, 2008Date of Patent: December 6, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Aiden Flanagan, David McMorrow, Anthony Malone, Tim O'Connor
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Patent number: 8066764Abstract: A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.Type: GrantFiled: December 23, 2009Date of Patent: November 29, 2011Assignee: Greatbatch Ltd.Inventors: Robert C. O'Brien, Christine A. Frysz
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Patent number: 8062350Abstract: Provided herein is a method of using a bioabsorbable medical device that includes RGD attached to the device via a spacer compound. The method comprises implanting in a human being a bioaborbable device, e.g., a bioabsorbable stent, including a chemo-attractant for endothelial progenitor cells (EPCs).Type: GrantFiled: February 21, 2008Date of Patent: November 22, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Bin Huang, Kleine Klaus
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Patent number: 8061298Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. A method supporting a stent during the application of a coating substance is also provided.Type: GrantFiled: March 10, 2010Date of Patent: November 22, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Jason Fox, Nathan Harold, Barry Templin, Andrew Tochterman
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Patent number: 8057536Abstract: An implant comprising an implant material forming a base made of one or more metallic elements; a diffusion layer covering the base made of at least one of the metallic elements of the implant material and at least magnesium; and, optionally, a metal layer covering the diffusion layer made of magnesium or a biocorrodible magnesium alloy.Type: GrantFiled: June 13, 2008Date of Patent: November 15, 2011Assignee: Biotronik VI Patent AGInventors: Heinz Mueller, Peter Uggowitzer, Joerg Loeffler
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Patent number: 8057535Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link.Type: GrantFiled: March 22, 2011Date of Patent: November 15, 2011Assignee: Nano Vasc, Inc.Inventors: Craig Hashi, Daniel Francis Davidson
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Patent number: 8057534Abstract: A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.Type: GrantFiled: September 14, 2007Date of Patent: November 15, 2011Assignee: Boston Scientific SciMed, Inc.Inventors: Dennis A. Boismier, Timothy S. Girton, Steven R. Larsen, Matt Shedlov, Ken Merdan, Barry O'Brien
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Patent number: 8052746Abstract: The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stem on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group.Type: GrantFiled: July 23, 2007Date of Patent: November 8, 2011Assignee: Biocompatibles LimitedInventors: Peter William Stratford, Alistair Stewart Taylor, Vincent James O'Byrne, John Tom Clarke, Denis Dominic Healy
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Patent number: 8053019Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating.Type: GrantFiled: February 3, 2010Date of Patent: November 8, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Stephen D. Pacetti, Jeff Royal, Dorie M. Happ, Kurt Scheinpflug, Ty Hu
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Patent number: 8051798Abstract: A mounting assembly for a stent and a method of coating a stent using the assembly are provided.Type: GrantFiled: January 27, 2010Date of Patent: November 8, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Charles Snyder, Anh Tran, Arthur J. Wen
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Publication number: 20110270387Abstract: This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione).Type: ApplicationFiled: April 29, 2010Publication date: November 3, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: Yunbing Wang, Xiao Ma, Lothar Kleiner, Thierry Glauser
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Patent number: 8048151Abstract: A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.Type: GrantFiled: October 22, 2009Date of Patent: November 1, 2011Assignee: Greatbatch Ltd.Inventors: Robert C. O'Brien, Christine A. Frysz
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Publication number: 20110264197Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.Type: ApplicationFiled: March 25, 2011Publication date: October 27, 2011Inventors: Brian L. Bates, Anthony O. Ragheb, Joseph M. Stewart, IV, William J. Bourdeau, Brian D. Choules, James D. Purdy, Neal E. Fearnot
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Patent number: 8043355Abstract: A double-tube type stent is inserted into a hollow tubular organ such as a bile duct so as to relieve narrowing of the bile duct on, for instance, an anastomotic area of the intrahepatic bile duct of a liver transplant patient. A hollow cylindrical body has a plurality of rhombic spaces formed by weaving a superelastic shape-memory-alloy wire so as to be crossed. A silicon coating layer is coated on an outer surface of the cylindrical body using a silicon solution. A polytetrafluoroethylene (PTFE) tube is fixedly fitted around the cylindrical body having the silicon coating layer leaving a gap therebetween.Type: GrantFiled: December 29, 2008Date of Patent: October 25, 2011Assignees: Taewoong Medical Co., Ltd.Inventors: Kyong-Min Shin, Jeung-Hee Nam
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Publication number: 20110257732Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: April 13, 2011Publication date: October 20, 2011Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor
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Publication number: 20110238153Abstract: Endoprostheses include an endoprosthesis wall that includes a surface layer that includes a metallic material and that defines a plurality of discrete pores. A porous material is disposed in one or more pores of the surface layer. The endoprostheses can, for example, deliver a therapeutic agent, such as a drug, in a controlled manner over an extended period of time.Type: ApplicationFiled: March 23, 2011Publication date: September 29, 2011Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Liliana Atanasoska, Angela Kostrewa, Rajesh Radhakrishnan, Robert W. Warner, Lagiang Tran, James Lee Shippy, III, Edward E. Parsonage
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Publication number: 20110238162Abstract: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.Type: ApplicationFiled: February 22, 2011Publication date: September 29, 2011Applicant: Arsenal MedicalInventors: Rany Busold, Chang Cheng You, Daniel Concagh, Lee Core, Kicherl Ho, Maria Palasis, Upma Sharma, Greg Zugates
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Publication number: 20110238161Abstract: This disclosure describes the application of a supplemental corona source to provide surface charge on submicrometer particles to enhance collection efficiency and micro-structural density during electrostatic collection.Type: ApplicationFiled: March 26, 2010Publication date: September 29, 2011Applicants: BATTELLE MEMORIAL INSTITUTE, MICELL TECHNOLOGIESInventors: John L. Fulton, George S. Deverman, Dean W. Matson, Clement R. Yonker, C. Douglas Taylor, James B. McClain, Joseph M. Crowley
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Publication number: 20110238163Abstract: There is provided a device comprising a body structure having one or more surfaces wherein at least one of the surfaces comprises a pH sensitive layer comprising a linear polymer, wherein the water solubility of the linear polymer increases from a first water solubility to a second water solubility at a pH trigger. A method of forming a device, and a method of preventing or mitigating infection is also described.Type: ApplicationFiled: March 8, 2011Publication date: September 29, 2011Applicant: LABORATORIOS FARMACEUTICOS ROVI S.A.Inventors: GAVIN Paul ANDREWS, DAVID Simon JONES, SEAN Patrick GORMAN
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Patent number: 8025916Abstract: A composite stent and a method for making the same are provided.Type: GrantFiled: December 18, 2006Date of Patent: September 27, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Orlando Padilla, Daryush Mirzaee, Fuh-Wei Tang
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Patent number: 8020273Abstract: A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.Type: GrantFiled: January 22, 2010Date of Patent: September 20, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventor: Stephen Dirk Pacetti
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Publication number: 20110224783Abstract: An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes.Type: ApplicationFiled: May 25, 2011Publication date: September 15, 2011Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Michael Kuehling
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Patent number: 8016881Abstract: The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution containing monomers and the agent to form a coating, using multiple cycles of swelling a polymer with a solvent-agent solution to increase loading, microparticles carrying the agent, biodegradable surgical articles with amphiphilic copolymer coatings, and sutures or surgical staples the deliver a drug selected from the group consisting of triazolopyrimidine, paclitaxol, sirolimus, derivatives thereof, and analogs thereof to a wound site.Type: GrantFiled: September 7, 2004Date of Patent: September 13, 2011Assignee: ICON Interventional Systems, Inc.Inventor: Joseph G. Furst
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Patent number: 8015687Abstract: A method is disclosed comprising providing a self-expandable stent having a polymeric component. The stent is exposed to a relative humidity of 20% to 100% (RH) or a plasticizing agent is applied to the polymeric component. The diameter of the stent is reduced. The stent having a reduced diameter is inserted in a constraining sheath such that the sheath constrains the stent in a reduced diameter, such that removal of the stent from the sheath causes the stent to self-expand to a greater diameter.Type: GrantFiled: January 22, 2010Date of Patent: September 13, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventor: Stephen Dirk Pacetti
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Patent number: 8016879Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.Type: GrantFiled: June 27, 2007Date of Patent: September 13, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Bin Huang
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Patent number: 8011078Abstract: A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.Type: GrantFiled: January 22, 2010Date of Patent: September 6, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventor: Stephen Dirk Pacetti
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Patent number: 8007674Abstract: Described herein are devices and methods fabricating devices having nanostructures that allow adhesion or growth of one cell type, such as endothelial cells, more than another cell type, such as smooth muscle cells. In particular, stent covers having such nanostructures are described, and methods for fabricating these stent covers. Also described herein are methods for optimizing the nanostructures forming the devices.Type: GrantFiled: July 29, 2008Date of Patent: August 30, 2011Assignee: TiNi Alloy CompanyInventor: Alfred David Johnson
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Publication number: 20110208294Abstract: A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.Type: ApplicationFiled: May 2, 2011Publication date: August 25, 2011Applicant: ORBUSNEICH MEDICAL, INC.Inventor: Robert J. Cottone
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Patent number: 8002823Abstract: An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes.Type: GrantFiled: July 11, 2007Date of Patent: August 23, 2011Assignee: Boston Scientific SciMed, Inc.Inventor: Michael Kuehling
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Patent number: 8002821Abstract: Endoprostheses such as stents are disclosed that are, or that include portions that are, bioerodible.Type: GrantFiled: September 13, 2007Date of Patent: August 23, 2011Assignee: Boston Scientific SciMed, Inc.Inventor: Jonathan S. Stinson
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Patent number: 8002822Abstract: A medical device has a porous radiopaque coating that can withstand the high strains inherent in the use of such devices without delamination. A coating of Ta is applied to a medical device, such as a stent, by vapor deposition so that the thermomechanical properties of the stent are not adversely affected. The coating preferable has high emissivity.Type: GrantFiled: March 23, 2005Date of Patent: August 23, 2011Assignee: Isoflux, Inc.Inventors: David A. Glocker, Mark M. Romach
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Polymer-Bioceramic Composite Implantable Medical Device with Different Types of Bioceramic Particles
Publication number: 20110202126Abstract: Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed.Type: ApplicationFiled: April 28, 2011Publication date: August 18, 2011Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Yunbing Wang, David C. Gale, Syed F.A. Hossainy