Coating Patents (Class 623/1.46)
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Publication number: 20110040372Abstract: A stent structure (30) particularly for use in treating cerebral aneurysms is provided with a fibrous coating (34) which reduces the permeability of the underlying stent (32) to an extent that the flow through the stent structure is sufficiently suppressed to allow for resorbtion of an aneurysm while still providing sufficient flow through the stent structure to allow for flow into the perforator vessels. The fibrous coating may have different permeabilities in different zones of the underlying stent (32). The coating could be applied to other devices such as filters and occluders.Type: ApplicationFiled: February 13, 2009Publication date: February 17, 2011Inventors: Palle M. Hansen, Jesper Thyregod
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Publication number: 20110034990Abstract: One embodiment of the invention concerns an implant with a basic body of biocorrodible, metallic implant material with an active coating and/or cavity filling.Type: ApplicationFiled: July 6, 2010Publication date: February 10, 2011Inventor: Alexander Borck
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Publication number: 20110034996Abstract: One embodiment of the invention concerns a medical implant with the basic body having an antioxidative substance.Type: ApplicationFiled: July 20, 2010Publication date: February 10, 2011Inventor: Alexander Borck
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Publication number: 20110029069Abstract: A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.Type: ApplicationFiled: January 19, 2009Publication date: February 3, 2011Applicants: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION, SAMSUNG LIFE WELFARE FOUNDATIONInventors: Dae-Joong Kim, In-Su Baek, Jong-Sang Park, Hye-Yeong Nam, Chengzhe Bai
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Publication number: 20110029070Abstract: An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.Type: ApplicationFiled: October 18, 2010Publication date: February 3, 2011Inventors: Vipul Dave, Robert Falotico, Chengxue Li, Thai M. Nguyen, Theodore L. Parker, Jonathon Z. Zhao
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Patent number: 7879086Abstract: This invention is directed to a coating for a medical device, such as an intravascular stent, in which the coating, which comprises a first coating region comprising an adhesion promoter and a therapeutic agent. The coating can also include a second coating region which is substantially free of the adhesion promoter or any adhesion promoter. The invention is also directed to a method for manufacturing such a coated medical device.Type: GrantFiled: April 20, 2006Date of Patent: February 1, 2011Assignee: Boston Scientific Scimed, Inc.Inventor: Liza J Davis
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Patent number: 7879085Abstract: The present invention provides an expanded tubular graft formed of expanded polytetrafluoroethylene (ePTFE). The graft has first and second open ends and a surface longitudinally extending between the ends. The graft also includes an inner and outer cylindrical walls, where the walls have crimps or corrugations located along the surface of the graft. Additionally, the graft is coated with biocompatible elastomer covering portions of the outer cylindrical walls of the PTFE graft. The resulting ePTFE crimped graft exhibits various enhanced properties, such as adjustable graft length, high kink resistance, improved suture retention and high crush resistance as compared to the same graft without the crimps.Type: GrantFiled: September 6, 2002Date of Patent: February 1, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Krzysztof Sowinski, Jamie S Henderson
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Publication number: 20110022162Abstract: An endoprosthesis includes an endoprosthesis wall that includes a ceramic coating and a polymer coating containing a therapeutic agent. A ceramic coating can be formed on the wall by electrochemical deposition. Cyclic voltammetry can be conducted to modify the density of the hydroxyl groups on the surface of the ceramic coating.Type: ApplicationFiled: July 23, 2009Publication date: January 27, 2011Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Rajesh Radhakishnan, Liliana Atanasoska, Daniel VanCamp
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Publication number: 20110022161Abstract: The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices.Type: ApplicationFiled: June 6, 2007Publication date: January 27, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Kathryn E. Uhrich, Ashley Carbone
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Publication number: 20110022005Abstract: The present invention relates to a medical device having a coating comprising at least one polyurethaneurea, wherein the coating comprises at least one polyurethane urea terminated with a copolymer unit of polyethyloxide and polypropyloxide.Type: ApplicationFiled: March 16, 2009Publication date: January 27, 2011Applicant: BAYER MATERIALSCIENCE AGInventor: Jürgen Köcher
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Publication number: 20110015725Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.Type: ApplicationFiled: September 28, 2010Publication date: January 20, 2011Inventors: Brian L. Bates, Scott E. Boatman, David G. Burton, Michael C. Hoffa, Darin G. Schaeffer, Jason S. Sturgeon, Anthony O. Ragheb
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Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
Patent number: 7867592Abstract: Methods are disclosed for modifying at least a portion of a porous polymeric surface. Such methods include contacting the porous polymeric surface with at least one polyelectrolyte, resulting in the physical adsorption of at least one polyelectrolyte onto the porous polymeric surface to form a charge modified surface. Such coated surfaces may be part of a device or apparatus, including electroosmotic pumps.Type: GrantFiled: January 30, 2007Date of Patent: January 11, 2011Assignee: Eksigent Technologies, Inc.Inventors: Darcee Deschamp Nelson, Klaus Joachim Dahl -
Publication number: 20110004289Abstract: The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.Type: ApplicationFiled: September 3, 2010Publication date: January 6, 2011Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITEDInventors: Randolf Von Oepen, Gerd Seibold
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Publication number: 20100331969Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.Type: ApplicationFiled: September 2, 2010Publication date: December 30, 2010Inventor: Stephen D. PACETTI
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Publication number: 20100331967Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: ApplicationFiled: July 1, 2010Publication date: December 30, 2010Applicant: Angiotech Biocoatings Corp.Inventors: Richard J. WHITBOURNE, Alexandra M. CHAMBERLAIN, Daniel G. HULLIHEN, Scott F. ROSEBROUGH, Mildred CALISTRI-YEH
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Publication number: 20100331613Abstract: The present invention relates to a medical implant which is equipped with an antimicrobial composition which comprises silicon dioxide and metal-containing nanoparticles, and processes for producing the medical implant.Type: ApplicationFiled: October 29, 2008Publication date: December 30, 2010Applicants: AESCULAP AG, HEIQ MATERIALS AGInventors: Carlo Ricchardo Centonze, Murray Height, Ingo Berndt, Erich Odermatt
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Publication number: 20100318170Abstract: A stent delivery system for treating a diseased bifurcation vessel having a catheter with a securement feature. The delivery system includes a dual lumen catheter with one or more balloons and a specialized stent having a side port mounted on the balloon. The securement feature is a flap that retains a side branch guide wire near the catheter body and wherein the distal tip of the guide wire is positioned near the side port of the stent. At the bifurcation, the side branch guide wire is freed from the flap to advance into the side branch vessel through the stent side port.Type: ApplicationFiled: June 15, 2009Publication date: December 16, 2010Inventor: Richard Newhauser
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Patent number: 7850727Abstract: An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decreasing, sinusoidal, and other delivery profiles.Type: GrantFiled: November 14, 2005Date of Patent: December 14, 2010Assignee: Innovational Holdings, LLCInventor: John F. Shanley
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Publication number: 20100312331Abstract: A medical device, for example a stent, has a surface which in use contacts body tissue, wherein said surface has on it a biocompatible coating layer comprising a polymer having covalently bound allyl-terminated pendent groups, said pendent groups comprising a moiety selected from -0-CH2—CH?CH2—S—CH2—CH?CH2—S(=0)-CH2—CH?CH2—Se—CH2—CH?CH2 and —Se (=0 J-CH2—CH?CH2. This surface has good biocompatibility and can bind strongly to a metallic surface. The polymer may be made from an electropolymerisable monomer, e.g. a pyrrole.Type: ApplicationFiled: May 15, 2008Publication date: December 9, 2010Applicant: CHAMELEON BIOSURFACES LIMITEDInventors: Christopher John Pickett, Timothy James Boote, Saad Khalil Ibrahim, Jane Marie Knott, John Douglas Tolland
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Publication number: 20100305689Abstract: The present invention relates to the field of non-biodegradable stents, and therein to non-biodegradable stents coated with at least one layer of a biodegradable polymer which maintains mechanical integrity of the coating both in storage and upon balloon expansion and which can optionally release drugs. The at least one polymer layer comprises a biodegradable polymer and a plasticizer. The present invention also relates to a manufacturing method of such a non-biodegradable stent.Type: ApplicationFiled: October 30, 2008Publication date: December 2, 2010Inventors: Subramanian Venkatraman, Yin Chiang Boey, Laxmikant Khanolkar
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Patent number: 7837726Abstract: A crack-resistant endoprosthesis for delivery in a body lumen can be comprised of a multilayered material. The multilayered material can include at least two layers having a boundary layer therebetween. The boundary layer is configured to inhibit cracks from propagating from a first layer-to a second layer. The different layers can be comprised of the same materials or different materials. It can be preferred that the multilayered material have layers that are comprised of resiliently-flexible materials, shape memory materials, and/or radiopaque materials.Type: GrantFiled: March 13, 2006Date of Patent: November 23, 2010Assignee: Abbott LaboratoriesInventors: Randolf Von Oepen, Anton G. Clifford, Travis R. Yribarren
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Publication number: 20100292776Abstract: A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodible metal compositions are different.Type: ApplicationFiled: May 14, 2009Publication date: November 18, 2010Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Jan Weber, Torsten Scheuermann
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Publication number: 20100286766Abstract: A modified medical device substrate surface designed to improve adhesion of biomimetic surfactants to the medical device surface, thus reducing the risk of thrombosis is described. The surface modification is accomplished through either an application of a tie layer of a hydrophobic material on the substrate surface intermediate the biomimetic coating or through incorporation of a hydrophobic dopant in the polymeric substrate prior to extrusion or molding. Either method creates a hydrophobically modified surface that enhances the biomimetic surfactant bonding strength.Type: ApplicationFiled: May 7, 2010Publication date: November 11, 2010Applicant: Greatbatch, Ltd.Inventor: Qingshan Ye
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Publication number: 20100285094Abstract: Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions.Type: ApplicationFiled: April 20, 2007Publication date: November 11, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventor: Kavita Gupta
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Publication number: 20100286765Abstract: The invention provides a medical device coated with Ap4A and/or an Ap4A analog. In a preferred embodiment the medical device is a vascular stent.Type: ApplicationFiled: May 7, 2009Publication date: November 11, 2010Inventor: Paul Zamecnik
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Publication number: 20100280599Abstract: This invention relates to novel calcium phosphate coated implantable medical devices, and electrochemical deposition processes for making same. A process of coating an implantable medical device with a calcium phosphate coating comprising: (a) subjecting a substrate to a surface pretreatment whereby adhesion of the calcium phosphate coating to the substrate is enhanced; (b) immersing the pretreated substrate in an electrolyte comprising calcium and phosphate species; and (c) coating calcium phosphate onto the substrate by electrochemical deposition.Type: ApplicationFiled: June 20, 2007Publication date: November 4, 2010Inventors: Pui Hung Manus Tsui, Tomasz Trocynski
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Publication number: 20100280601Abstract: The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 ??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 ??(IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.Type: ApplicationFiled: May 12, 2010Publication date: November 4, 2010Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
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Publication number: 20100280594Abstract: Disclosed is an antithrombotic neurovascular device useful for the treatment of brain aneurysms and/or acute ischemic stroke. The device comprises a mechanical structure, which may be a stent, stent-like structure, or flow diverter, and a drug-eluting coating. This device is designed for local delivery of antiplatelet medication to the site of device implantation in order to improve outcomes for the population of brain aneurysm and/or acute ischemic stroke patients currently being treated with stents, and for use with patients presenting with ruptured aneurysms, in whom systemic dual antiplatelet therapy is contraindicated. The coating comprises an antiplatelet drug, preferably, a GPIIb/IIIa receptor inhibitor, more preferably, abcixmab, and optionally comprises a polymeric binder that functions as a drug modulating polymer. Also disclosed are methods for producing the antithrombotic neurovascular device, and using the device for the treatment of brain aneurysms and/or acute ischemic stroke.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Applicant: MEDI-SOLVE, LLCInventors: Ronald A. Sahatjian, Ajay K. Wakhloo
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Publication number: 20100274352Abstract: An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.Type: ApplicationFiled: April 24, 2009Publication date: October 28, 2010Applicant: Boston Scientific Scrimed, Inc.Inventors: Michael Kuehling, Torsten Scheuermann, Jan Weber, Yixin Xu
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Patent number: 7819914Abstract: An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.Type: GrantFiled: December 16, 2008Date of Patent: October 26, 2010Assignee: Cordis CorporationInventors: Vipul Dave, Robert Falotico, Chengxue Li, Thai M. Nguyen, Theodore L. Parker, Jonathon Z. Zhao
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Patent number: 7820229Abstract: Coatings for stents that include a polymer and a drug are provided. A method of forming the coatings is also provided.Type: GrantFiled: November 8, 2006Date of Patent: October 26, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Veronica J. Santos, Santosh Prabhu
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Publication number: 20100266659Abstract: Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: ApplicationFiled: April 19, 2010Publication date: October 21, 2010Applicant: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Publication number: 20100268070Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.Type: ApplicationFiled: November 24, 2009Publication date: October 21, 2010Inventors: Farouc Jaffer, Milind Rajopadhye
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Publication number: 20100268330Abstract: Implants with a calcium phosphate containing layer are disclosed. The implants, which can have a metallic character (e.g., made from a cobalt chromium alloy), can include a surface that is exposed to one or more formulations that results in a chemical and/or physical modification. In some instances, the modified surface is texturized so as to include a plurality of surface pits. The average pit size opening can range, for example, from 40 nm to about 10 ?m, and can include a plurality of average pit sizes in some cases. The modified surfaces can promote growth of a calcium phosphate layer, which can be accelerated relative to conventional techniques. Other variations of such implant surfaces, and methods of producing similar implant surfaces, are also discussed.Type: ApplicationFiled: April 15, 2009Publication date: October 21, 2010Applicant: DePuy Products, Inc.Inventors: Weidong Tong, Lawrence Salvati, Pooja Kadambi
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Patent number: 7815962Abstract: A stent includes a stent framework and a coating disposed on the stent framework. The coating includes an inner surface and an outer surface. The coating has a circumferential therapeutic concentration zone near the inner surface and a circumferential washed zone near the outer surface.Type: GrantFiled: March 22, 2007Date of Patent: October 19, 2010Assignee: Medtronic Vascular, Inc.Inventor: Joseph Berglund
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Publication number: 20100262230Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elementsType: ApplicationFiled: November 14, 2008Publication date: October 14, 2010Applicant: BIOSENSORS INTERNATIONAL GROUP, LTD.Inventors: Ivan Vecerina, Vinh Pham
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Publication number: 20100262229Abstract: The invention relates to intraluminal endoprosthesis, preferably a stent consisting essentially of a base body and optionally a coating covering the surface of the base body at least partially. The invention is characterized in that the base body and/or the coating has at least one compound from the group of polyphosphates, magnesium oxyhalides, preferably Sorel cement. Furthermore, a method is described for manufacturing such an intraluminal endoprosthesis.Type: ApplicationFiled: July 27, 2009Publication date: October 14, 2010Applicant: BIOTRONIK VI PATENT AGInventor: Roland Rohde
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Publication number: 20100262228Abstract: The present disclosure generally relates to implantable medical devices having a metallic surface coated with a bioabsorbable primer polymer layer under a bioabsorbable drug polymer layer. Thus, in addition to the degradation of the drug polymer layer, there is degradation of the primer layer. The underlying metallic framework may or may not degrade depending on whether bioabsorbable or biostable metals are chosen.Type: ApplicationFiled: April 10, 2009Publication date: October 14, 2010Applicant: Medtronic Vascular, Inc.Inventors: Kishore Udipi, Ya Guo
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Publication number: 20100256747Abstract: The invention relates to an implant of a biocorrodible metallic material with a passivating coating of a nanoparticle-containing silane coating and an associated method for producing the implant.Type: ApplicationFiled: March 4, 2010Publication date: October 7, 2010Inventors: Timo Hausbeck, Alexander Rzany
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Publication number: 20100256728Abstract: Described herein are biodegradable stent grafts and methods for treatment of early stage aneurysms and acute vessel injuries. The stent frameworks themselves are a biodegradable metal and the graft material is a semi-permeable, biodegradable porous fabric. The pores are sufficiently small to block the passage of monocytes through the semi-permeable fabric and sufficiently large to allow the passage of ions and small molecules through the semi-permeable fabric. The biodegradable stent grafts degrade completely leaving no permanent metal structures (or any structures at all) in the patient and therefore do not need to be later surgically removed or monitored.Type: ApplicationFiled: April 7, 2009Publication date: October 7, 2010Applicant: Medtronic Vascular, Inc.Inventor: Susan Rea Peterson
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Publication number: 20100256746Abstract: Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.Type: ApplicationFiled: March 23, 2010Publication date: October 7, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: Douglas Taylor, James B. McClain, Edward E. Schmitt
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Publication number: 20100256748Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: March 31, 2010Publication date: October 7, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: Douglas Taylor, James B. McClain
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Patent number: 7806924Abstract: Medical devices, and in particular implantable structures, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization.Type: GrantFiled: February 18, 2004Date of Patent: October 5, 2010Assignee: Cordis CorporationInventors: Robert Falotico, Tom Jay Parry, Jonathon Z. Zhao
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Patent number: 7807211Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.Type: GrantFiled: May 27, 2004Date of Patent: October 5, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Manish Gada
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Publication number: 20100249914Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.Type: ApplicationFiled: June 2, 2010Publication date: September 30, 2010Applicants: HIROO IWATAInventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Publication number: 20100249900Abstract: An implant is proposed, in particular made from a base material including a biodegradable metal and/or a biodegradable metal alloy, wherein the implant includes a coating made of crystalline calcium phosphate and/or amorphous calcium phosphate.Type: ApplicationFiled: March 24, 2010Publication date: September 30, 2010Applicant: BIOTRONIK VI Patent AGInventors: Laura Sager, Bjoern Klocke, Heinz Mueller, Nina Adden, Gerhard Kappelt
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Publication number: 20100247597Abstract: The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted.Type: ApplicationFiled: March 31, 2009Publication date: September 30, 2010Applicant: Medtroni Vascular, Inc.Inventors: Mingfei Chen, Peiwen Cheng, Kishore Udipi
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Patent number: 7803183Abstract: A medical device with a coating for capturing target cells in vivo is provided. In particular, the medical device is coated with at least one layer of matrix and a layer of antibodies, antibody fragments or combinations thereof, which bind with specificity to mature or progenitor endothelial cells at various developmental stages to form an endothelial cell layer on the surface of the device. The coated medical device can be, for example, a stent or a synthetic graft and is useful in therapy of diseases such as restenosis, atherosclerosis, and thromboembolic complications.Type: GrantFiled: April 26, 2004Date of Patent: September 28, 2010Assignee: OrbusNeich Medical, Inc.Inventors: Michael John Bradley Kutryk, Robert John Cottone, Jr., Stephen Maxwell Rowland
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Publication number: 20100239505Abstract: An apparatus having an echogenic coating of a polymer with hollow spaces present in the polymer. In order to achieve an echogenicity that supplies largely isotropic ultrasonic echo images, the hollow spaces should be microhollow spheres embedded in the polymer.Type: ApplicationFiled: March 16, 2010Publication date: September 23, 2010Applicant: RUGER MEDICAL GMBHInventors: Rudolf REICHL, Bernhard SCHRÖDER
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Publication number: 20100241220Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: March 22, 2010Publication date: September 23, 2010Inventors: James B. McClain, Douglas Taylor