Supported By Resilient Frame Patents (Class 623/2.14)
  • Patent number: 12029649
    Abstract: Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: July 9, 2024
    Assignee: Cook Medical Technologies LLC
    Inventors: Sean Chambers, Ram Paul
  • Patent number: 12023240
    Abstract: A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets, a cuff at least partially disposed on a luminal surface of the stent, and a covering material disposed on an abluminal surface of the stent and covering the at least one runner in the second configuration.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: July 2, 2024
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Kent J. Smith, Andrea L McCarthy
  • Patent number: 12011352
    Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: June 18, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose Navia, Samir Kapadia, Torey Hovest, Richard Geoffrion, Robert Farnan
  • Patent number: 12004948
    Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: June 11, 2024
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
  • Patent number: 11992403
    Abstract: A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and/or engage a wire to aid in positioning, expansion, recapture and/or implanting the device in a patient's heart chamber.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 28, 2024
    Assignee: 4C Medical Technologies, Inc.
    Inventors: Jonathan Berndt, Sounthara Khouengboua, Saravana Kumar
  • Patent number: 11974922
    Abstract: Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.
    Type: Grant
    Filed: August 8, 2023
    Date of Patent: May 7, 2024
    Assignee: Cook Medical Technologies LLC
    Inventors: Sean Chambers, Ram Paul
  • Patent number: 11969344
    Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: April 30, 2024
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Christopher J. Olson, Glen T. Rabito, Dustin P. Armer, Minh T. Ma, Devin H. Marr, Cheng-Tung Huang, Hiroshi Okabe, Kevin M. Stewart, Alison S. Curtis, Philip P. Corso, Jr.
  • Patent number: 11969339
    Abstract: A prosthetic valve comprising a tubular shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons having proximal and distal ends, the distal ends of the ribbons projecting from the sheet member proximal end.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: April 30, 2024
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 11931261
    Abstract: A prolapse prevention device formed by a continuous wire-like structure having a first end and a second end disconnected from each other. The continuous wire-like structure of the prolapse prevention device is substantially straight in a delivery configuration. The prolapse prevention device in a deployed configuration includes a centering ring of the continuous wire-like structure configured to seat adjacent to and upstream of an annulus of a heart valve in situ, a vertical support of the continuous wire-like structure which extends from the centering ring and includes an apex configured to seat against a roof of an atrium in situ, and a leaflet backstop of the continuous wire-like structure extending radially inward from the centering ring and configured to contact at least at least a first leaflet of the heart valve in situ to exert a pressure in a downstream direction on the first leaflet to prevent the first leaflet from prolapsing into the atrium.
    Type: Grant
    Filed: February 17, 2022
    Date of Patent: March 19, 2024
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Niall Duffy, David Farascioni, Adam Fitzgerald, Nathan Knutson, Ana Menk, Aran Murray, Jay Rassat
  • Patent number: 11844691
    Abstract: An implant includes an expandable frame having a continuous lumen and has (a) an upstream row of upstream cells and (b) at least two downstream rows of downstream cells. An upstream portion of each cell is shaped by ascending and descending struts that form a respective peak that points in an upstream direction. A valve member is disposed within the lumen and facilitates unidirectional flow of blood from an upstream end of the frame to a downstream end of the frame. A covering has (i) a first portion entirely covering an outer surface of a downstream row of downstream cells, and (ii) a second portion partially covering an outer surface of an upstream row of downstream cells. Outer surfaces of the peaks of the upstream row of downstream cells are disposed upstream of an upstream end of the covering at the outer surface. Other embodiments are also described.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: December 19, 2023
    Assignee: CARDIOVALVE LTD.
    Inventor: Tal Hammer
  • Patent number: 11844690
    Abstract: A prosthetic valve includes a tubular frame, a multi-leaflet valve, movable rods, and a flange. The frame includes a lattice, an inflow end portion, and an outflow end portion. The frame is movable between radially collapsed and expanded states. The lattice deflects as the frame moves between the radially collapsed and expanded states. The valve is disposed within and coupled to the frame and is configured to allow one-way blood flow therethrough. The rods are coupled to the lattice of the frame and are configured to facilitate movement of the frame between the radially collapsed and expanded states. The flange is coupled to and extends radially outwardly from the frame and includes deflectable petals. The petals include a first petal having a first length and a second petal having a second length, and the first length is different than the second length.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: December 19, 2023
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Jorge H. Jimenez, James L. Greene
  • Patent number: 11833039
    Abstract: A collapsible prosthetic heart valve includes a collapsible and expandable stent and a collapsible and expandable valve assembly. The stent has a proximal end and a distal end. A plurality of commissure points is disposed on the stent. The valve assembly is disposed within the stent and includes a plurality of leaflets. Each leaflet has a free edge. An end portion of the free edge of each leaflet is folded and sutured to a corresponding one of the plurality of the commissure points.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 5, 2023
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Yousef F. Alkhatib, Peter N. Braido
  • Patent number: 11826249
    Abstract: A heart valve repair device may include a support configured to extend through a native annulus of a native heart valve, wherein the support comprises an upstream portion and a downstream portion; an annular expandable retainer extending from the upstream portion of the support, and an arm extending from the downstream portion of the support. The annular expandable retainer may include a C-shaped cross-section that is open inwardly. The arm may be configured to reach behind a leaflet of the native heart valve and sandwich the leaflet between the arm and the support.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: November 28, 2023
    Assignee: Twelve, Inc.
    Inventors: John Morriss, Hanson S. Gifford, III, James I. Fann, Jean-Pierre Dueri, Darin Gittings, Michael Luna, Mark E. Deem, Douglas S Sutton
  • Patent number: 11819404
    Abstract: A prosthetic heart valve includes a radially expandable annular frame and a valve body disposed inside the frame. The valve body includes three leaflets configured to regulate the flow of blood through the frame in one direction. The prosthetic heart valve also includes an annular inner skirt secured to an inner surface of the frame. The inner skirt has an inflow edge oriented toward an inflow end of the frame, an outflow edge oriented toward an outflow end of the frame, and first and second lateral edges extending from the inflow edge to the outflow edge, wherein the first lateral edge and the second lateral edge are secured together. The first lateral edge and the second lateral edge are oriented at an oblique angle relative to a plane that is perpendicular to a central longitudinal axis of the frame.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: November 21, 2023
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 11786641
    Abstract: An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 17, 2023
    Assignee: The Texas A&M University System
    Inventors: Duncan J. Maitland, Adam M. Orendain
  • Patent number: 11771554
    Abstract: A transcatheter valve prosthesis includes a stent and a prosthetic valve disposed within the stent. The stent is balloon expandable and includes an inflow portion, an outflow portion, and a transition portion extending between the inflow portion and the outflow portion. A diameter of an inflow end of the transcatheter valve prosthesis is greater than a diameter of an outflow end of the transcatheter valve prosthesis. The transcatheter valve prosthesis has a tapered profile along an entire height thereof when in the stent is in the expanded configuration. The inflow end of the transcatheter valve prosthesis is configured to sit within and contact an aortic annulus of the native aortic valve and the outflow end of the transcatheter valve prosthesis being configured to float within an ascending aorta without contacting the ascending aorta due to the tapered profile of the transcatheter valve prosthesis.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: October 3, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Justin Peterson, Tracey Tien, Michael Krivoruchko, Yas Neuberger, Stuart Kari, Justin Goshgarian
  • Patent number: 11737870
    Abstract: A prosthetic heart valve (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion and a ring portion that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: August 29, 2023
    Assignee: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Yousef F. Alkhatib
  • Patent number: 11690714
    Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: July 4, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Brian S. Conklin, Qinggang Zeng
  • Patent number: 11678983
    Abstract: Implantable devices may include a single, first component or a plurality of components such as first and second components, the second component being flexibly coupled to the first component. A socket extends over one or more of the component(s), the socket being configured to enhance the inter-component interaction and/or including one or more exposed surface(s) configured to exhibit one or more tiers of foreign body responses within a range of possible foreign body responses.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: June 20, 2023
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Rachel Radspinner, Ian Smith, Patrick S. Young
  • Patent number: 11672654
    Abstract: A prosthetic heart valve includes a stent extending in a longitudinal direction and having a collapsed condition and an expanded condition. The stent includes a plurality of struts forming cells and a plurality of commissure attachment features spaced apart in an annular direction of the stent and extending in a medial direction of the stent. A valve assembly is secured to the commissure attachment features, the valve assembly including a cuff and a plurality of leaflets, each of the leaflets having a free edge and being capable of alternating between an open position and a closed position. A method of manufacturing the prosthetic heart valve is also provided.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: June 13, 2023
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Richard Kaleta
  • Patent number: 11672653
    Abstract: A prosthesis for implantation within a native valve is disclosed. The prosthesis includes a frame defining a lumen, and a tubular component formed of a flexible sheet that is attached to the frame to extend from a first end of the frame, wherein an interior of the tubular component is configured to support a prosthetic valve and is in fluid communication with the lumen of the frame. The prosthesis also includes a wire at least partially slidably disposed within the flexible sheet of the tubular component and operable to transition the tubular component into a deployed configuration that at least partially engages tissue at the native valve.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: June 13, 2023
    Assignee: Medtronic, Inc.
    Inventors: Paul Rothstein, Jeffrey Sandstrom
  • Patent number: 11666444
    Abstract: Described is a collapsible atrial cage for percutaneous delivery and implantation of an atrioventricular valve within an atrium of the heart. The atrial cage includes an atrial portion and a ventricular portion. The ventricular portion is attached with and separated from the atrial portion by a valve juncture portion. Notably, the cage includes at least one interlock shaped to lock with and secure an atrioventricular valve proximate the valve juncture portion. Thus, when deployed and expanded, the atrioventricular valve is secured at the atrioventricular juncture.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: June 6, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Arash Kheradvar, Gregory S. Kelley
  • Patent number: 11660185
    Abstract: A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Mark Chau, Marlowe E. Patterson, Seung-Beom Yi, Stephen C. Geist, Travis Zenyo Oba
  • Patent number: 11654022
    Abstract: A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: May 23, 2023
    Assignee: Medtronic, Inc.
    Inventors: Carol E. Eberhardt, Faisal Kalam
  • Patent number: 11654017
    Abstract: An implantable valve replacement system for a cardiovascular valve may include an adjustable stabilizing ring. The stabilizing ring may be composed of a body member that is transitionable from an elongate insertion geometry to an annular operable geometry. The stabilizing ring may further include a plurality of anchors deployable in the annular operable geometry to engage the annulus of the cardiovascular valve. The ring may be used in conjunction with an implantable valve frame. The valve frame may be located within the ring and the ring, in turn, may be stabilized through the anchors engaging the valve annulus. The valve replacement system may be applied by engaging the ring in its annular operable geometry with the valve annulus through the anchors. The valve frame may be inserted through the opening of the ring, thereby forming a stabilizing mechanical contact between the frame and the annulus.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: May 23, 2023
    Assignee: VALCARE, INC.
    Inventors: Samuel M. Shaolian, Nadav Yellin, Avraham Eftel, Jeffrey Dumontelle
  • Patent number: 11654020
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate valve-in-valve (ViV) procedures. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates ViV procedures.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: May 23, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Brian S. Conklin, Qinggang Zeng, Myron Howanec, Jr., Grace Myong Kim
  • Patent number: 11653948
    Abstract: A system and method of accessing a heart of a patient is provided. A cardiac access channel is established through an apical wall of the heart to provide direct access through the apical wall to the left ventricle. A vascular access channel is established through the skin to a peripheral blood vessel. A first end of an elongate member is advanced from the outside of the apical wall through the cardiac access channel and into the left ventricle. A second end disposed opposite the first end remains outside the patient. The elongate member is drawn into and through the vascular access channel to externalize the first end of the elongate member while leaving the second end outside the apical wall of the heart.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: May 23, 2023
    Assignee: Cedars-Sinai Medical Center
    Inventor: Robert James Siegel
  • Patent number: 11571297
    Abstract: Apparatus and methods are described herein for a secondary valve apparatus that can be deployed within an existing implanted prosthetic heart valve. In some embodiments, a secondary prosthetic heart valve apparatus is implanted in series with an existing deteriorating implanted prosthetic valve. The secondary valve apparatus can restore proper valve function without disruption to the failing previously implanted valve. In some embodiments, the secondary valve apparatus can be positioned on an atrial portion of the existing valve, and be delivered transseptally. In other embodiments, the secondary valve apparatus can be positioned at a ventricular portion of the existing valve and delivered transapically. Devices and methods to prepare the existing valve to receive a secondary valve apparatus are also described herein. In some embodiments, a balloon expansion device can be used to expand an inner diameter of the existing valve to provide space for the secondary valve to be disposed.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: February 7, 2023
    Assignee: Tendyne Holdings, Inc.
    Inventors: Zachary J. Tegels, Michael J. Urick
  • Patent number: 11504230
    Abstract: The present disclosure relates to an arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve. With the method or the arrangement, leakage or regurgitation between a prosthetic heart valve and the surrounding valve tissue is prevented. In one embodiment, an arrangement for replacement or repair of a native heart valve is provided, which comprises a loop-shaped support 41 and a prosthetic heart valve 70 and wherein an outer segment 32 of the loop-shaped support 41 is positionable towards surrounding valve tissue of a native heart valve and wherein an outer surface 74 of the prosthetic heart valve 70 is positionable towards an inner segment 34 of the loop-shaped support 41 so as to prevent paravalvular leakage or regurgitation between the prosthetic heart valve 70 and the surrounding valve tissue of the native heart valve.
    Type: Grant
    Filed: May 2, 2021
    Date of Patent: November 22, 2022
    Inventor: Olli Keränen
  • Patent number: 11452598
    Abstract: Embodiments of the present disclosure are directed to stents, valved-stents, (e.g., single-stent-valves and double stent/valved-stent systems) and associated methods and systems for their delivery via minimally-invasive surgery. The stent component comprises a first stent section (102) a second stent section (104) a third stent section (106) and a fourth stent section (108).
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: September 27, 2022
    Assignee: Symetis SA
    Inventors: Jacques Essinger, Serge Delaloye, Jean-Luc Hefti, Stephane Delaloye
  • Patent number: 11446143
    Abstract: A collapsible and expandable stent body includes a generally tubular annulus section, one or more prosthetic valve elements mounted to the stent body, and a cuff attached to the stent body. The prosthetic valve is operative to allow flow in an antegrade direction but to substantially block flow in a retrograde direction. The prosthetic heart valve may include paravalvular leak mitigation features in the form of first and second sealing members. The sealing members are attached to the cuff and extend circumferentially around an abluminal surface of the stent body. The sealing members each have an open side facing in a first axial direction and a closed side facing in an opposite second axial direction. Flow of blood in the second axial direction will tend to force blood into the sealing members and cause the sealing members to billow outwardly relative to the stent body, helping to mitigate paravalvular leak.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: September 20, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim
  • Patent number: 11426275
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent and a plurality of commissure features disposed on the stent. A collapsible and expandable valve assembly includes a plurality of leaflets connected to the plurality of commissure features, each commissure feature including a body having a proximal end and a distal end. A plurality of eyelets is arranged in rows and columns on the body for distributing load from the plurality of leaflets.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: August 30, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter Nicholas Braido, Jacob John Daly, Julia Ann Schraut
  • Patent number: 11382740
    Abstract: A prosthetic heart valve is designed to be circumferentially collapsible for less invasive delivery into the patient. At the implant site the valve re-expands to a larger circumferential size, i.e., the size that it has for operation as a replacement for one of the patient's native heart valves. The valve includes structures that, at the implant site, extend radially outwardly to engage tissue structures above and below the native heart valve annulus. These radially outwardly extending structures clamp the native tissue between them and thereby help to anchor the prosthetic valve at the desired location in the patient.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: July 12, 2022
    Assignee: St. Jude Medical, LLC
    Inventor: Peter N. Braido
  • Patent number: 11351028
    Abstract: A device and method for predictably and controlling the collapsing of a collapsible and expandable stent for subsequent translation through a delivery sheath lumen to an anatomical target such as a heart valve or intravascular location for expansion and implantation. The loading device defines in inner lumen comprising a successively decreasing, from the proximal to the distal direction, inner diameter alternating between two sections of decreasing diameter and two sections of constant diameter until reaching the inner diameter of the delivery sheath. A fluid-filled reservoir is provided at the proximal end of the loading device that is configured to provide moisture or wetting for materials associated with or attached to the stent that require moisture retention. Thus, as the stent is being collapsed with the loading device, at least a portion of the stent may be immersed in the fluid reservoir to preserve the subject material.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 7, 2022
    Assignee: 4C Medical Technologies, Inc.
    Inventors: Alex A. Peterson, Jason S. Diedering, Saravana B. Kumar
  • Patent number: 11298889
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: April 12, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Itai Pelled, Elena Sherman, Eran Goldberg, Kevin D. Rupp, Noam Nir
  • Patent number: 11278396
    Abstract: A prosthetic mitral valve includes a collapsible and expandable stent extending from an inflow end to an outflow end. A collapsible and expandable valve assembly is disposed within the stent. The valve assembly includes a plurality of anterior leaflets and one posterior leaflet. The posterior leaflet has a larger surface area than any of the anterior leaflets. When implanted in the native mitral valve annulus, the smaller size of the anterior leaflets and the corresponding smaller size of an anterior portion of the stent reduce the likelihood of interference with blood flowing through the native aortic valve, while also reducing the likelihood of ventricular fibrillation.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 22, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Brandon Moore
  • Patent number: 11266499
    Abstract: A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: March 8, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Derrick Johnson, Van Huynh, Qinggang Zeng
  • Patent number: 11266502
    Abstract: A cardiac valve repair implant, wherein the implant includes a central occluder, and frame and a thin sheet. The central occluder includes a central longitudinal axis. The frame extends proximally from the central occluder and is centered about and forms a circumference around the central longitudinal axis of the central occluder. The frame self-biases from a collapsed state to an expanded state. A proximal end of the frame projects proximally when the frame is in the collapsed state. The proximal end of the frame projects radially outward away from the central longitudinal axis of the central occluder when the frame is in the expanded state. The thin sheet is supported on a proximal portion of the frame. When the frame is in the expanded state, the thin sheet forms an annular surface defining an inner circular opening centered about the central longitudinal axis of the central occluder.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: March 8, 2022
    Assignee: Versa Vascular Inc.
    Inventors: Daniel T. Wallace, Juan Granada, Jeremy J. Boyette, Peter W. Gregg, Spencer C. Noe, Evelyn N. Haynes
  • Patent number: 11229516
    Abstract: A prosthetic heart valve (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion and a ring portion that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: January 25, 2022
    Assignee: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Yousef F. Alkhatib
  • Patent number: 11213388
    Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: January 4, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
  • Patent number: 11185407
    Abstract: The invention describes a stent of the aortic valve which is self-expandable and also repositionable and preferably made from nitinol. It consists of two parts: the upper part and the lower part. The lower part is a mesh (1) laid out so that it creates a kind of cylinder wall on the entire height of the element. Also other shape of the mesh is acceptable, for example partially conical, or partially resembling flattened side wall of the cylinder. However, the upper part of the stent consists of derived from the mesh (1) upwards and arranged at equal intervals three arms (2) the height of which is slightly larger than the height of the mesh (1), a bit less than the height of the mesh (1) or equal to its height. The stent arms (2) are shaped in such a way that they form together a kind of an oval chalice bowl, and their end, peripheral part is preferably straight and also inclined to the middle. Space between the arms (2) always ensures free access to patient's coronary arteries.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: November 30, 2021
    Inventor: Piotr Chodór
  • Patent number: 11116631
    Abstract: A method of delivering a prosthetic heart valve to a native aortic heart valve region of a patient can include introducing a prosthetic heart valve on a transvascular delivery apparatus into an artery of the patient, advancing the delivery apparatus through an aorta of the patient to the native aortic heart valve region, and releasing the prosthetic heart valve from the delivery apparatus. The delivery apparatus can have a shaft with a valve connection portion that is releasably coupled to posts of the prosthetic heart valve. The delivery apparatus can have a delivery sheath positioned around the prosthetic heart valve and the valve connection portion. The releasing the prosthetic valve can include moving the delivery sheath proximally relative to the shaft and the prosthetic heart valve such that the delivery sheath uncovers the prosthetic heart valve and the prosthetic heart valve can self-expand.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: September 14, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Alon, Netanel Benichou, Oded Meiri
  • Patent number: 11109962
    Abstract: Bioprosthetic heart valves and methods for fabricating bioprosthetic heart valves are provided. Biological tissue is attached to biocompatible material. The biocompatible material is folded to form a tubular structure with the attached biological tissue located on the inner surface of the tubular structure, the biological tissue forming leaflets of the heart valve. A stent is secured around the outer surface of the tubular structure. A region of the biocompatible material is cut. The biocompatible material is folded at the cut region away from the tissue and around the downstream edge of the stent and is secured to the stent's outer surface. The biocompatible material is folded at the upstream end of the tubular structure around the upstream edge of the stent and attached to the stent's outer surface so that the stent's inner and outer surfaces are covered with no more than a single layer of the biocompatible material.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: September 7, 2021
    Assignee: UCL Business PLC
    Inventors: Gaetano Burriesci, Benyamin Rahmani, Guerard Byrne, Christopher Mcgregor
  • Patent number: 11045311
    Abstract: A prosthetic heart valve, for example a tricuspid valve, may include a flexible membrane and a frame. The frame may be attached to the periphery of the tricuspid orifice. The diaphragm may be attached to the frame around a part of the perimeter of the orifice. Optionally the frame may be flexible. For example the frame may elastically flex between a substantially circular shape and/of an elliptical and/or crescent shape. Optionally there may not be a stiff cross piece crossing a central region of the orifice and connected on opposing sides of frame. In some embodiments, the diaphragm may take a dome shape during systole.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: June 29, 2021
    Assignee: Trisol Medical Ltd.
    Inventors: Mordehay Vaturi, Tal Gollan
  • Patent number: 11007058
    Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 18, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson
  • Patent number: 11007053
    Abstract: Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: May 18, 2021
    Assignee: St. Jude Medical, LLC
    Inventors: Peter Nicholas Braido, Andrea L. McCarthy, Rubem L. Figueiredo, Julia A. Schraut
  • Patent number: 10932909
    Abstract: A device for treating regurgitation of a tricuspid valve (4) is disclosed. The device comprises a tricuspid valve plug (21) capable of compressing and expanding and a tricuspid valve plug fixing device used for anchoring the tricuspid valve-in-plug (21) to an orifice of the tricuspid valve (4). The tricuspid valve plug (21) is provided with an inflow end (42, 52) and an opposite outflow end (47, 57), and a prosthetic valve (50, 70) capable of being opened and closed is disposed in the tricuspid valve plug (21). When the tricuspid valve (4) is dosed, the prosthetic valve (50, 70) is automatically closed, and when the tricuspid valve (4) is opened, the prosthetic valve (50, 70) is automatically opened.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: March 2, 2021
    Assignee: SHANGHAI JOY MEDICAL DEVICES CO., LTD
    Inventors: Shouyan Lee, Hongxia Nan
  • Patent number: 10898320
    Abstract: Prosthetic heart valves and anchors for use with such valves are provided that allow for an improved implantation procedure. In various embodiments, an anchoring device is formed as a coiled or twisted anchor that includes one or more turns that twist or curve around a central axis. One or more arms attached to the frame of the valve guide the anchoring device into position at the native valve as it exits the delivery catheter, and the expandable prosthetic valve is held within the coil of the anchoring device. The anchoring device and the valve can be delivered together, simplifying the valve replacement procedure.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 26, 2021
    Assignee: Mitral Valve Technologies Sarl
    Inventors: Paul A. Spence, Landon H. Tompkins
  • Patent number: 10799345
    Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body. The prosthetic valve may also include a plurality of tissue anchors arranged about the valve body and configured to extend from connection points on the valve body. The prosthetic valve may also include at least one protective fabric covering extending over each of the connection points between each tissue anchor and the valve body.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 13, 2020
    Assignee: CardioValve Ltd.
    Inventors: Ilia Hariton, Meni Iamberger, Aviram Baum, Boaz Harari
  • Patent number: 10722355
    Abstract: Prosthetic valve systems for replacing a native valve exhibiting regurgitation include a support structure and a transcatheter heart valve (THV) that is separate from the support structure. The support structure can be configured to be positioned such that it extends annularly around the native valve leaflets. After the support structure is deployed around the native valve leaflets, the THV can be expanded within the support structure such that the native valve leaflets are engaged between the support structure and the THV.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 28, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Stanton J. Rowe, Francesco Maisano, Oded Meiri