Heart Valve Patents (Class 623/2.1)
  • Patent number: 11413147
    Abstract: A method for treating a heart valve involves introducing a delivery catheter into a target ventricle of a heart, the delivery catheter having a coil device disposed at least partially therein, deploying a distal end of the coil device from the delivery catheter, navigating the distal end of the coil device behind a plurality of trabeculae carneae features associated with an inner wall of the ventricle to form one or more coils, and tightening the one or more coils to reduce a diameter of the target ventricle.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: August 16, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Travis Zenyo Oba
  • Patent number: 11406499
    Abstract: An easy-to-control interventional instrument delivery device, comprising a core tube (7), a guiding head (2) and a fixing head (3) being fixed onto the core tube (7); the guiding head (2) is fixed at a distal end of the core tube (7), and the fixing head (3) extends from a proximal end side of the core tube (7), an interventional instrument mounting position being located between the guiding head (2) and the fixing head (3); the outer periphery of the interventional instrument mounting position is provided with an axially skiable outer sheathing tube (5), further being provided with a floating limiting strip (1); a proximal end of the floating limiting strip (1) is a starting end (13) that is connected near the fixed head (3), and a distal end is a terminal end (11, 101) that floats between the interventional instrument mounting position and the outer sheathing tube (5).
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 9, 2022
    Assignee: Venus Medtech (Hangzhou) Inc.
    Inventors: Zhifei Zhang, Zhenjun Zi, Min Frank Zeng, Quangang Gong
  • Patent number: 11399934
    Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The prosthetic valve comprises a frame or stent that comprises multiple cells arranged in unique ways. The prosthetic valve also comprises a leaflet assembly coupled to the frame and having a plurality of leaflets, wherein the leaflets are configured to allow blood to flow through the prosthetic heart valve in one direction from an inflow end portion to an outflow end portion of the frame or stent.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 2, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Sergio Delgado, Jun Liu, Luca Pesce, Asher L. Metchik
  • Patent number: 11318011
    Abstract: A frame for a prosthetic heart valve includes a plurality of strut members arranged to form an annular main body and coupled together by a plurality of pivot joints. The main body of the frame is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration, and the frame has an inflow end and an outflow end. The frame further includes a plurality of leaflet clamps disposed on the exterior of the main body of the frame and coupled to the strut members. The leaflet clamps are movable between an open position corresponding to the collapsed configuration of the frame and a closed position corresponding to the expanded configuration of the frame. Motion of the main body of the frame between the collapsed configuration and the expanded configuration causes corresponding motion of the leaflet clamps between the open position and the closed position.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: May 3, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Yair A. Neumann
  • Patent number: 11318017
    Abstract: A stented valve suitable for use in body ducts. The valve includes an expandable support structure and an attached flexible membrane that changes shape when the valve opens and closes. The expandable support structure has the shape of a stent with a series of interconnected expandable unit cells and elongated support beams. When the valve is open, body fluid can flow around the membrane and pass through the gap between it and the inner stent surface. In one configuration, a set of two valves is combined with an intermediate inflatable balloon to create a cardiac assist pumping device. In another embodiment, valve closure can be achieved by remotely controlled valve leaflets actuation. A double aorta valve frame is used to accommodate shape and diameter variations of the annulus in an outer valve frame, while the inner valve frame has dimensions for optimized performance of the valve membrane.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: May 3, 2022
    Inventor: Petrus A. Besselink
  • Patent number: 11298227
    Abstract: The invention relates to a heart valve regurgitation drum and optional closure disk and/or tubular stent to manage and provide levels of intentional regurgitation within an orthogonally delivered transcatheter prosthetic heart valve having a first inner flow control component/valve, a second inner regurgitation control component, and an outer annular support frame having compressible wire cells that facilitate folding flat along the z-axis and compressing the valve vertically along the y-axis, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: April 12, 2022
    Assignee: VDyne, Inc.
    Inventors: Robert Vidlund, Mark Christianson, Neelakantan Saikrishnan
  • Patent number: 11298117
    Abstract: A method is provided, including (1) identifying the subject as having mitral valve regurgitation; (2) during a medical procedure, in response to identifying the subject as having mitral valve regurgitation, implanting a prosthetic valve at a mitral valve site of the heart; and (3) during the same medical procedure, implanting a therapeutic septal device at a septum of the heart. Other embodiments are also described.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: April 12, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Tal Reich, Paul Kaye
  • Patent number: 11291571
    Abstract: A growth stent and valve and methods for making and using the same. The growth stent and valve may be delivered to treat early stage congenital lesions, while expanding to adult vessel diameters. In selected embodiments, the growth stent and valve can comprise a frame and may have a covering on some portion to prevent blood flow through a wall of the frame. The growth stent and valve advantageously can maintain radial strength across an entire range of diameters necessary to treat a narrowed lesion from birth and childhood through adulthood as the vessels grow over the lifetime of a patient.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: April 5, 2022
    Assignee: Renata Medical, Inc.
    Inventors: Dustin Armer, Eason Abbott
  • Patent number: 11273031
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: March 15, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tomer Saar, Michael Bukin, Elena Sherman, Alexander Barash, Yana Mayatskaya
  • Patent number: 11246706
    Abstract: A prosthetic heart valve may include a stent having an inflow end, an outflow end, a collapsed condition, and an expanded condition. The prosthetic valve may also include a collapsible and expandable valve assembly disposed within the stent and having a plurality of leaflets. The prosthetic valve and/or stent may include features to anchor the prosthetic valve to a native valve annulus and to seal the prosthetic valve with respect to the native valve annulus, such as planar and/or nonplanar annular sealing members coupled to ends of the stent. The stent may include one or more circumferential rows of anchor members or hooks extending radially outwardly from the stent. These hooks may be configured to extend in a particular direction when the stent is in the collapsed condition to facilitate resheathing of the stent if, upon deployment, a user determines the prosthetic heart valve is not positioned optimally.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: February 15, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Theodore Paul Dale, Andrea N. Para, Gaurav Satam, Jason Diedering, Thomas Mark Benson, Saravana B. Kumar
  • Patent number: 11179238
    Abstract: A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: November 23, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Louis A. Campbell, Donald E. Bobo, Jr., Gregory A. Wright, Tak G. Cheung
  • Patent number: 11166705
    Abstract: Several unique intra-cardiac pressure devices, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure devices presented allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms. The intra-cardiac pressure devices are made of a non-braided material.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: November 9, 2021
    Assignee: Corvia Medical, Inc.
    Inventors: Edward McNamara, David Celermajer, Stephen Forcucci, Hiroatsu Sugimoto
  • Patent number: 11129712
    Abstract: Prosthetic heart valves having elastic leaflets and an elastic support structure are described. The support structure can store a load transferred from the leaflets as potential energy and then release it in the form of kinetic energy to exhibit a precursory transition from the closed position to the open position. The support structures can exhibit a sinusoidal movement profile at a base edge during the precursory transition.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: September 28, 2021
    Assignee: FOLDAX, INC.
    Inventor: Jason G. Beith
  • Patent number: 11116635
    Abstract: The present invention relates to a device for cardiac valve repair, the device comprising: at least one upstream anchoring means adapted to anchor to at least one tissue site, the tissue site located upstream with respect to a heart valve of a patient; and a coaptation structure arranged to extend from the upstream anchoring means, the coaptation structure comprising a free end, wherein the coaptation structure is operable to extend across the heart valve and locate the free end downstream from the heart valve and the coaptation structure operable to coapt with at least one heart valve leaflet of the patient's heart to prevent and/or minimize a backflow of blood. The present invention is suitable for the treatment of heart valves using minimally invasive approaches. Additionally, the present invention is directed to a method of implanting a device for cardiac valve repair in a patient's heart.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: September 14, 2021
    Assignee: SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Khung Keong Yeo, Nicolas Daniel Marie Foin
  • Patent number: 11065115
    Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: July 20, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
  • Patent number: 11051937
    Abstract: An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Diana Nguyen-Thien-Nhon, Timothy A. Geiser, Larry L. Wood, Dinesh L. Sirimanne, Son V. Nguyen, Tamir S. Levi, Nikolay Gurovich, Michael Bukin
  • Patent number: 11039924
    Abstract: Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: June 22, 2021
    Assignee: MITRALIX LTD.
    Inventor: Ira Yaron
  • Patent number: 11039859
    Abstract: A method for treating a spinal disorder includes the steps of: disposing an expandable spinal construct in a selected configuration; fixing the spinal construct in the selected configuration with a member; attaching a first end of the spinal construct with tissue; attaching a second end of the spinal construct with tissue; and disengaging the member from the spinal construct to release the spinal construct from the selected configuration. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 22, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 11033390
    Abstract: Prosthetic heart valve devices with tethered anchors and associated systems and methods are disclosed herein. A heart valve device configured in accordance with embodiments of the present technology can include, for example, a valve support for carrying a prosthetic valve. The valve support can be configured to be implanted at an annulus of a native mitral valve. The device can further include at least one elongated flexible member extending from the valve support in a ventricular direction, and an anchor coupled to the valve support via the elongated flexible member. The anchor can be shaped to wrap around an exterior area of an apical portion of the heart. In addition, the anchor can inhibit retrograde migration of the valve support.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 15, 2021
    Assignee: Medtronic Vascular, Inc.
    Inventor: Mike Krivoruchko
  • Patent number: 11026672
    Abstract: Described herein are methods and apparatus for approximating targeted tissue by intertwining two or more sutures together. The sutures are attached to the targeted tissue and routed to a twister device. The twister device secures end portions of the sutures and twists them to intertwine the sutures. Controlling the number of twists provides control over the forces applied to the targeted tissue. In conjunction with visualization feedback, real-time adjustments can be made to achieved targeted results, such as elimination of mitral regurgitation when the disclosed methods and apparatus are applied to mitral valve repair.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 8, 2021
    Assignees: Harpoon Medical, Inc., University of Maryland, Baltimore
    Inventors: William Niland, Felino V. Cortez, Jr., James S. Gammie, Michael Nicholas D'ambra, Peter Wilson, Stephen Cournane
  • Patent number: 10939997
    Abstract: Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 9, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Randall Lashinski, Matthew Rust, Patrick Macaulay, Richard Glenn
  • Patent number: 10925733
    Abstract: An exemplary valve repair device for repairing a native valve of a patient has a paddle frame, and inner and outer paddle portions formed from a strip of metal fabric. The paddle frame has a round three-dimensional shape. The strip of metal fabric is attached to a closed attachment portion of the paddle frame.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 23, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Sergio Delgado, Eric Robert Dixon, David M. Taylor
  • Patent number: 10918479
    Abstract: A stent (1) used for a heart valve prosthesis and the heart valve prosthesis that includes the stent (1) and is used for heart valve replacement. The stent is configured to support a heart valve (3) and includes, along a longitudinal axis, an inflow section (8), an outflow section (6) and a transition section (7) between the inflow section (8) and the outflow section (6). The stent (1) has a contracted delivery configuration and an expanded deployed configuration. In the expanded deployed configuration, the inflow section (8) defines a concave contour that is complementary to a structure of a native valve annulus. The concave contour enables self-deployment and close adherence of the stent (1), thereby preventing its displacement and perivalvular leakage after implantation.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: February 16, 2021
    Assignee: SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO., LTD.
    Inventors: Guoming Chen, Yu Li, Feng Huang, Lei Huang, Jianchao Han, Yihao Duan, Shaohui Chen, Qiyi Luo
  • Patent number: 10874512
    Abstract: The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures/tethers which maintain proximal tension on the valve prior to deployment.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: December 29, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Randolf von Oepen, Sean A. McNiven, Francisco Valencia
  • Patent number: 10849746
    Abstract: A delivery device includes a central elongate structure including an annular member at the distal end, a sheath, a plurality of tethers extending through the central elongate structure, a handle, and a control on the handle. The handle is connected to the elongate structure, the sheath, and the plurality of tether. The control is configured to move the sheath proximally and distally over the central elongate structure. The annular member includes a plurality of pockets extending radially therearound. Each tether includes a feature on a distal end thereof configured to fit within a pocket of the plurality of pockets to hold the tether in place.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 1, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Peter Gregg, Dan Wallace, Aaron Grogan, Crissly Crisostomo
  • Patent number: 10849747
    Abstract: A delivery device for an implantable medical device includes an inner shaft with a device-carrying region, an outer shaft surrounding the inner shaft, a sheath at a distal end of the outer shaft, and a sleeve. The outer shaft is movable relative to the inner shaft from an advanced position in which the sheath surrounds the device-carrying region to a retracted position in which the sheath exposes the device-carrying region. The sheath includes a proximal structure having a cylindrical portion between first and second transition zones. The sleeve surrounds the outer shaft and is movable relative to the outer shaft from an advanced position in which a distal end portion of the sleeve surrounds the cylindrical portion to a retracted position in which the distal end portion of the sleeve is spaced proximally from the cylindrical portion.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: December 1, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Michael Shane Morrissey, Tyler Govek, John Matejka
  • Patent number: 10820989
    Abstract: In various embodiments, provided herein are methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve. These methods, devices and systems are used to treat patients with mitral valve disease, particularly those who have had failed edge-to-edge leaflet repair, or patients presently considered anatomically unsuitable for edge-to-edge leaflet repair alone.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 3, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventor: Hasanian Al-Jilaihawi
  • Patent number: 10751170
    Abstract: The present invention provides a modular prosthetic valve device having two or more device modules for percutaneous delivery unassembled at or near the valve implantation site and assembly at least in part using a self-assembly member, and a system and method of folding, delivering and assembling the device. The device modules may include a support structure and a valve module. The valve module has an unassembled, folded delivery configuration, and an unfolded, assembled (via the self-assembly member) working configuration. The valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and may be reverted to a preset configuration for valve module assembly. The unassembled valve module may be rolled along its circumferential axis towards its height to a folded diameter equivalent to one rolled leaflet, providing a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 25, 2020
    Assignee: Valve Medical Ltd.
    Inventors: Yoram Richter, Jacob Richter, Ety Weisz
  • Patent number: 10736738
    Abstract: A prosthetic heart valve including a stent frame and a valve structure. The valve structure is disposed within a lumen of the stent frame. The stent frame is configured to self-expand from a compressed condition for transluminal delivery. The stent frame has a lattice structure forming a tubular shape defining a circumference and a plurality of closed cells arranged to define a band exhibiting a variable radial stiffness. The prosthesis can be deployed such that the band applies a minimal force on to anatomical locations relating to the heart's conductive pathways. A region of the band otherwise having low radial stiffness is located at or over a conductive pathway upon final implant.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 11, 2020
    Assignee: Medtronic Vascular Galway
    Inventors: Rodney Bell, Declan Costello
  • Patent number: 10709560
    Abstract: A prosthetic mitral valve designed to resemble a patient's nat-ural mitral valve is provided. The prosthetic mitral valve includes an asym-metrical, flexible ring dimensioned to match a native mitral annulus of a pa-tient, two leaflets suspended from the flexible ring, and at least two sets of cords attached to the leaflets and merging into two bundles to be fabricated using pre-operative three-dimensional imaging technologies.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: July 14, 2020
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventor: Theodoros Kofidis
  • Patent number: 10639146
    Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: May 5, 2020
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10548732
    Abstract: Embodiments of the present disclosure include a device for repositioning papillary muscles. The device may comprise a band configured to encircle a cluster of papillary muscles. The cluster of papillary muscles may have an outer peripheral boundary defined by the encircling band, and the band may comprise a first end and a second end. The device may further comprise an adjustable clasp coupled to a location proximate the first end of the band. The clasp may be configured to transition from an open configuration to a closed configuration to connect the second end of the band to the first end of the band, thereby forming a loop. The clasp may be selectively actuatable to adjust a length of the loop.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: February 4, 2020
    Assignee: Cardiac Success Ltd.
    Inventor: David Neustadter
  • Patent number: 10499941
    Abstract: This document provides devices and methods for repairing a prolapsing mitral valve leaflet using minimally invasive catheter based approaches. For example, percutaneous procedures that involve folding and securing a segment of a prolapsing leaflet onto or pulling and securing a segment of a prolapsing leaflet through part of the greater mitral valve leaflet are provided. In some cases, artificial chordae are installed to stabilize and maintain desired orientation of the leaflets.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: December 10, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Rakesh M. Suri
  • Patent number: 10485660
    Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: November 26, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10463488
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a method of implanting a prosthetic valve within a native mitral valve may be provided. The method may include delivering the prosthetic valve into a heart chamber. The prosthetic valve may be constrained in a contracted delivery configuration. The prosthetic valve may include an annular valve body with a plurality of ventricular anchors and a plurality of atrial anchors attached thereto. The method may also include unconstraining the plurality of ventricular anchors and the plurality of atrial anchors while maintaining the valve body in the contracted delivery configuration. The method may also include unconstraining the valve body from the contracted delivery configuration while the unconstrained atrial anchors are positioned within an atrium and while the unconstrained ventricular anchors are positioned within a ventricle.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: November 5, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10463487
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a method of releasing a valve from a delivery capsule in a heart may be provided. The method may include moving a distal capsule portion of the delivery capsule a first distance in the heart in a first direction. Such movement may release ventricular anchoring legs of the valve from the capsule, The method may also include moving a proximal capsule portion of the delivery capsule a second distance in a second direction in the heart. The first direction may be opposite the second direction. Such movement may release atrial anchoring arms of the valve from the capsule. The method may also include moving the distal capsule portion a third distance in the first direction in the heart, to thereby release an annular valve body of the valve from the capsule.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: November 5, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10456255
    Abstract: The present invention comprises a novel and safer mechanism of deployment using a self-positioning, self-centering, and self-anchoring method. To embody the present invention, a disk-based valve apparatus allowing the repositioning and retrieval of the implantable valve while working on a dysfunctional valve structure is disclosed. The disk-based valve apparatus may comprise one or more disks, either proximal or distal, a valve-housing component and a valve component. The one or more disks may be either proximal or distal, may be either connected to each other or disconnected from each other and may either be symmetrical or have different shapes and dimensions. The disk-based valve apparatus may be self anchoring, such as anchored by pressure from the one or more disk, or may be anchored using any anchoring.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: October 29, 2019
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Matteo Montorfano, Alaide Chieffo, Juan F. Granada
  • Patent number: 10441414
    Abstract: The present invention provides a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner laye
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 15, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas K├Ânig
  • Patent number: 10433953
    Abstract: Prosthetic mitral valves and their methods of manufacture and use.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: October 8, 2019
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Dan Wallace, Aaron Grogan, Spencer Noe, Peter Gregg
  • Patent number: 10397803
    Abstract: A cellular communications network may be configured to leverage a millimeter wave (mmW) mesh network. Base stations may be configured to operate as mmW base stations (tnBs). Such base stations may be configured to participate in the mmW mesh network and to access the cellular communications network (e.g., via cellular access links). A network device of the cellular communications network (e.g., an eNB) may operate as a control entity with respect to one or more niBs. Such a network device may govern mesh backhaul routing with respect to the cellular communications network and the mmW mesh network. Such a network device may configure the mmW mesh network, for example by performing a process to join a new mB to the mmW mesh network. A WTRU may send and receive control information via a cellular access fink and may send and receive data via the mmW mesh network.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: August 27, 2019
    Assignee: IDAC Holdings, Inc.
    Inventors: Onur Sahin, Samian Kaur, Philip J. Pietraski, Ravikumar V. Pragada, Douglas R. Castor, Arnab Roy
  • Patent number: 10383729
    Abstract: A heart valve therapeutic device has an elongate anchor wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar arranged to provide a desired shape to the anchor and it may be lockable. A prosthetic valve element has leaflets and is supported on the anchor by coupler at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 20, 2019
    Assignee: The Provost, Fellows Foundation Scholars, and The Other Members of the Board, of the College of The Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10368987
    Abstract: One aspect of the present disclosure includes a system comprising prosthetic chordae, at least one attachment member including a channel, a female securing member, and a papillary penetration member configured to pass through the channel, the chordae, and the securing member when implanted in a patient's heart. The penetration member includes an axis.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: August 6, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: A. Marc Gillinov, Michael K. Banbury, Jeremy Hemingway, Craig B. Berky, Jonathan Bauer
  • Patent number: 10363069
    Abstract: A spinal construct includes at least one body including a first biasing member engageable with a longitudinal element for translation thereof relative to the body in a first direction. A second biasing member is engageable with a lock. The lock is connected with the longitudinal element to resist and/or prevent translation of the longitudinal element relative to the body in a second direction. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 30, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 10335199
    Abstract: A method for treating a spinal disorder includes the steps of: disposing an expandable spinal construct in a selected configuration; fixing the spinal construct in the selected configuration with a member; attaching a first end of the spinal construct with tissue; attaching a second end of the spinal construct with tissue; and disengaging the member from the spinal construct to release the spinal construct from the selected configuration. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 2, 2019
    Assignee: Warsaw Orthopedic. Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 10293082
    Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 21, 2019
    Assignee: Clemson University Research Foundation
    Inventors: Leslie Sierad, Eliza Laine Shaw, George Fercana, Dan Simionescu
  • Patent number: 10258466
    Abstract: Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: April 16, 2019
    Assignee: Millipede, Inc.
    Inventors: Randall Lashinski, Matthew Rust, Patrick Macaulay, Richard Glenn
  • Patent number: 10251748
    Abstract: Embodiments hereof relate to centering devices for use with a valve delivery system and methods of delivering a valve prosthesis within a vasculature. A valve centering catheter is configured for use with a valve delivery system. The valve centering catheter includes a circumferential centering device at a distal portion thereof, and the circumferential centering device defines a central opening there-through when in an expanded configuration. The circumferential centering device is annular or has a C-shaped cross-section. The valve delivery system is tracked through the vasculature until the valve prosthesis is positioned through the central opening of the expanded circumferential centering device. The valve centering catheter may alternatively include a longitudinal centering device which acts as a marker for depth control during delivery of a valve delivery system, which may include an integral circumferential centering device.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 9, 2019
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Constantin Ciobanu, Niall Duffy, Frank White
  • Patent number: 10226332
    Abstract: A prosthetic heart valve includes a stent extending in a longitudinal direction, the stent being formed of a plurality of struts forming cells and having a plurality of commissure features, a collapsed condition and an expanded condition. A valve assembly may be secured to the stent, the valve assembly including a cuff and a plurality of leaflets. The cuff may be formed of a fabric and a second material different from the fabric, the cuff having commissure peaks and a plurality of midpeaks disposed between the commissure peaks. Each of the leaflets may have a free edge.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: March 12, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Kent J. Smith, Andrea L. McCarthy, Mina S. Fahim
  • Patent number: 10219900
    Abstract: This invention relates to a delivery apparatus and method for deployment of a mitral valve replacement.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: March 5, 2019
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli
  • Patent number: 10195023
    Abstract: A prosthetic heart valve includes a base and one or more heart valve leaflets. At least a portion of the leaflet including a composite material that contains a polymer substrate and a pre-stressed reinforcement element at least partially disposed in the polymer substrate.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Thomas A. Wrobel