Heart Valve Patents (Class 623/2.1)
  • Patent number: 11065115
    Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: July 20, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
  • Patent number: 11051937
    Abstract: An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Diana Nguyen-Thien-Nhon, Timothy A. Geiser, Larry L. Wood, Dinesh L. Sirimanne, Son V. Nguyen, Tamir S. Levi, Nikolay Gurovich, Michael Bukin
  • Patent number: 11039859
    Abstract: A method for treating a spinal disorder includes the steps of: disposing an expandable spinal construct in a selected configuration; fixing the spinal construct in the selected configuration with a member; attaching a first end of the spinal construct with tissue; attaching a second end of the spinal construct with tissue; and disengaging the member from the spinal construct to release the spinal construct from the selected configuration. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 22, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 11039924
    Abstract: Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: June 22, 2021
    Assignee: MITRALIX LTD.
    Inventor: Ira Yaron
  • Patent number: 11033390
    Abstract: Prosthetic heart valve devices with tethered anchors and associated systems and methods are disclosed herein. A heart valve device configured in accordance with embodiments of the present technology can include, for example, a valve support for carrying a prosthetic valve. The valve support can be configured to be implanted at an annulus of a native mitral valve. The device can further include at least one elongated flexible member extending from the valve support in a ventricular direction, and an anchor coupled to the valve support via the elongated flexible member. The anchor can be shaped to wrap around an exterior area of an apical portion of the heart. In addition, the anchor can inhibit retrograde migration of the valve support.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 15, 2021
    Assignee: Medtronic Vascular, Inc.
    Inventor: Mike Krivoruchko
  • Patent number: 11026672
    Abstract: Described herein are methods and apparatus for approximating targeted tissue by intertwining two or more sutures together. The sutures are attached to the targeted tissue and routed to a twister device. The twister device secures end portions of the sutures and twists them to intertwine the sutures. Controlling the number of twists provides control over the forces applied to the targeted tissue. In conjunction with visualization feedback, real-time adjustments can be made to achieved targeted results, such as elimination of mitral regurgitation when the disclosed methods and apparatus are applied to mitral valve repair.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 8, 2021
    Assignees: Harpoon Medical, Inc., University of Maryland, Baltimore
    Inventors: William Niland, Felino V. Cortez, Jr., James S. Gammie, Michael Nicholas D'ambra, Peter Wilson, Stephen Cournane
  • Patent number: 10939997
    Abstract: Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 9, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Randall Lashinski, Matthew Rust, Patrick Macaulay, Richard Glenn
  • Patent number: 10925733
    Abstract: An exemplary valve repair device for repairing a native valve of a patient has a paddle frame, and inner and outer paddle portions formed from a strip of metal fabric. The paddle frame has a round three-dimensional shape. The strip of metal fabric is attached to a closed attachment portion of the paddle frame.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 23, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Sergio Delgado, Eric Robert Dixon, David M. Taylor
  • Patent number: 10918479
    Abstract: A stent (1) used for a heart valve prosthesis and the heart valve prosthesis that includes the stent (1) and is used for heart valve replacement. The stent is configured to support a heart valve (3) and includes, along a longitudinal axis, an inflow section (8), an outflow section (6) and a transition section (7) between the inflow section (8) and the outflow section (6). The stent (1) has a contracted delivery configuration and an expanded deployed configuration. In the expanded deployed configuration, the inflow section (8) defines a concave contour that is complementary to a structure of a native valve annulus. The concave contour enables self-deployment and close adherence of the stent (1), thereby preventing its displacement and perivalvular leakage after implantation.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: February 16, 2021
    Assignee: SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO., LTD.
    Inventors: Guoming Chen, Yu Li, Feng Huang, Lei Huang, Jianchao Han, Yihao Duan, Shaohui Chen, Qiyi Luo
  • Patent number: 10874512
    Abstract: The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures/tethers which maintain proximal tension on the valve prior to deployment.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: December 29, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Randolf von Oepen, Sean A. McNiven, Francisco Valencia
  • Patent number: 10849747
    Abstract: A delivery device for an implantable medical device includes an inner shaft with a device-carrying region, an outer shaft surrounding the inner shaft, a sheath at a distal end of the outer shaft, and a sleeve. The outer shaft is movable relative to the inner shaft from an advanced position in which the sheath surrounds the device-carrying region to a retracted position in which the sheath exposes the device-carrying region. The sheath includes a proximal structure having a cylindrical portion between first and second transition zones. The sleeve surrounds the outer shaft and is movable relative to the outer shaft from an advanced position in which a distal end portion of the sleeve surrounds the cylindrical portion to a retracted position in which the distal end portion of the sleeve is spaced proximally from the cylindrical portion.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: December 1, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Michael Shane Morrissey, Tyler Govek, John Matejka
  • Patent number: 10849746
    Abstract: A delivery device includes a central elongate structure including an annular member at the distal end, a sheath, a plurality of tethers extending through the central elongate structure, a handle, and a control on the handle. The handle is connected to the elongate structure, the sheath, and the plurality of tether. The control is configured to move the sheath proximally and distally over the central elongate structure. The annular member includes a plurality of pockets extending radially therearound. Each tether includes a feature on a distal end thereof configured to fit within a pocket of the plurality of pockets to hold the tether in place.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 1, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Peter Gregg, Dan Wallace, Aaron Grogan, Crissly Crisostomo
  • Patent number: 10820989
    Abstract: In various embodiments, provided herein are methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve. These methods, devices and systems are used to treat patients with mitral valve disease, particularly those who have had failed edge-to-edge leaflet repair, or patients presently considered anatomically unsuitable for edge-to-edge leaflet repair alone.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 3, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventor: Hasanian Al-Jilaihawi
  • Patent number: 10751170
    Abstract: The present invention provides a modular prosthetic valve device having two or more device modules for percutaneous delivery unassembled at or near the valve implantation site and assembly at least in part using a self-assembly member, and a system and method of folding, delivering and assembling the device. The device modules may include a support structure and a valve module. The valve module has an unassembled, folded delivery configuration, and an unfolded, assembled (via the self-assembly member) working configuration. The valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and may be reverted to a preset configuration for valve module assembly. The unassembled valve module may be rolled along its circumferential axis towards its height to a folded diameter equivalent to one rolled leaflet, providing a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 25, 2020
    Assignee: Valve Medical Ltd.
    Inventors: Yoram Richter, Jacob Richter, Ety Weisz
  • Patent number: 10736738
    Abstract: A prosthetic heart valve including a stent frame and a valve structure. The valve structure is disposed within a lumen of the stent frame. The stent frame is configured to self-expand from a compressed condition for transluminal delivery. The stent frame has a lattice structure forming a tubular shape defining a circumference and a plurality of closed cells arranged to define a band exhibiting a variable radial stiffness. The prosthesis can be deployed such that the band applies a minimal force on to anatomical locations relating to the heart's conductive pathways. A region of the band otherwise having low radial stiffness is located at or over a conductive pathway upon final implant.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 11, 2020
    Assignee: Medtronic Vascular Galway
    Inventors: Rodney Bell, Declan Costello
  • Patent number: 10709560
    Abstract: A prosthetic mitral valve designed to resemble a patient's nat-ural mitral valve is provided. The prosthetic mitral valve includes an asym-metrical, flexible ring dimensioned to match a native mitral annulus of a pa-tient, two leaflets suspended from the flexible ring, and at least two sets of cords attached to the leaflets and merging into two bundles to be fabricated using pre-operative three-dimensional imaging technologies.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: July 14, 2020
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventor: Theodoros Kofidis
  • Patent number: 10639146
    Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: May 5, 2020
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10548732
    Abstract: Embodiments of the present disclosure include a device for repositioning papillary muscles. The device may comprise a band configured to encircle a cluster of papillary muscles. The cluster of papillary muscles may have an outer peripheral boundary defined by the encircling band, and the band may comprise a first end and a second end. The device may further comprise an adjustable clasp coupled to a location proximate the first end of the band. The clasp may be configured to transition from an open configuration to a closed configuration to connect the second end of the band to the first end of the band, thereby forming a loop. The clasp may be selectively actuatable to adjust a length of the loop.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: February 4, 2020
    Assignee: Cardiac Success Ltd.
    Inventor: David Neustadter
  • Patent number: 10499941
    Abstract: This document provides devices and methods for repairing a prolapsing mitral valve leaflet using minimally invasive catheter based approaches. For example, percutaneous procedures that involve folding and securing a segment of a prolapsing leaflet onto or pulling and securing a segment of a prolapsing leaflet through part of the greater mitral valve leaflet are provided. In some cases, artificial chordae are installed to stabilize and maintain desired orientation of the leaflets.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: December 10, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Rakesh M. Suri
  • Patent number: 10485660
    Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: November 26, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10463487
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a method of releasing a valve from a delivery capsule in a heart may be provided. The method may include moving a distal capsule portion of the delivery capsule a first distance in the heart in a first direction. Such movement may release ventricular anchoring legs of the valve from the capsule, The method may also include moving a proximal capsule portion of the delivery capsule a second distance in a second direction in the heart. The first direction may be opposite the second direction. Such movement may release atrial anchoring arms of the valve from the capsule. The method may also include moving the distal capsule portion a third distance in the first direction in the heart, to thereby release an annular valve body of the valve from the capsule.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: November 5, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10463488
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a method of implanting a prosthetic valve within a native mitral valve may be provided. The method may include delivering the prosthetic valve into a heart chamber. The prosthetic valve may be constrained in a contracted delivery configuration. The prosthetic valve may include an annular valve body with a plurality of ventricular anchors and a plurality of atrial anchors attached thereto. The method may also include unconstraining the plurality of ventricular anchors and the plurality of atrial anchors while maintaining the valve body in the contracted delivery configuration. The method may also include unconstraining the valve body from the contracted delivery configuration while the unconstrained atrial anchors are positioned within an atrium and while the unconstrained ventricular anchors are positioned within a ventricle.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: November 5, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10456255
    Abstract: The present invention comprises a novel and safer mechanism of deployment using a self-positioning, self-centering, and self-anchoring method. To embody the present invention, a disk-based valve apparatus allowing the repositioning and retrieval of the implantable valve while working on a dysfunctional valve structure is disclosed. The disk-based valve apparatus may comprise one or more disks, either proximal or distal, a valve-housing component and a valve component. The one or more disks may be either proximal or distal, may be either connected to each other or disconnected from each other and may either be symmetrical or have different shapes and dimensions. The disk-based valve apparatus may be self anchoring, such as anchored by pressure from the one or more disk, or may be anchored using any anchoring.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: October 29, 2019
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Matteo Montorfano, Alaide Chieffo, Juan F. Granada
  • Patent number: 10441414
    Abstract: The present invention provides a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner laye
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 15, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Frederik Grundeman, Jolanda Kluin, Karlien Kristel Boon-Ceelen, Thomas König
  • Patent number: 10433953
    Abstract: Prosthetic mitral valves and their methods of manufacture and use.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: October 8, 2019
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Dan Wallace, Aaron Grogan, Spencer Noe, Peter Gregg
  • Patent number: 10397803
    Abstract: A cellular communications network may be configured to leverage a millimeter wave (mmW) mesh network. Base stations may be configured to operate as mmW base stations (tnBs). Such base stations may be configured to participate in the mmW mesh network and to access the cellular communications network (e.g., via cellular access links). A network device of the cellular communications network (e.g., an eNB) may operate as a control entity with respect to one or more niBs. Such a network device may govern mesh backhaul routing with respect to the cellular communications network and the mmW mesh network. Such a network device may configure the mmW mesh network, for example by performing a process to join a new mB to the mmW mesh network. A WTRU may send and receive control information via a cellular access fink and may send and receive data via the mmW mesh network.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: August 27, 2019
    Assignee: IDAC Holdings, Inc.
    Inventors: Onur Sahin, Samian Kaur, Philip J. Pietraski, Ravikumar V. Pragada, Douglas R. Castor, Arnab Roy
  • Patent number: 10383729
    Abstract: A heart valve therapeutic device has an elongate anchor wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar arranged to provide a desired shape to the anchor and it may be lockable. A prosthetic valve element has leaflets and is supported on the anchor by coupler at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 20, 2019
    Assignee: The Provost, Fellows Foundation Scholars, and The Other Members of the Board, of the College of The Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10368987
    Abstract: One aspect of the present disclosure includes a system comprising prosthetic chordae, at least one attachment member including a channel, a female securing member, and a papillary penetration member configured to pass through the channel, the chordae, and the securing member when implanted in a patient's heart. The penetration member includes an axis.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: August 6, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: A. Marc Gillinov, Michael K. Banbury, Jeremy Hemingway, Craig B. Berky, Jonathan Bauer
  • Patent number: 10363069
    Abstract: A spinal construct includes at least one body including a first biasing member engageable with a longitudinal element for translation thereof relative to the body in a first direction. A second biasing member is engageable with a lock. The lock is connected with the longitudinal element to resist and/or prevent translation of the longitudinal element relative to the body in a second direction. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 30, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 10335199
    Abstract: A method for treating a spinal disorder includes the steps of: disposing an expandable spinal construct in a selected configuration; fixing the spinal construct in the selected configuration with a member; attaching a first end of the spinal construct with tissue; attaching a second end of the spinal construct with tissue; and disengaging the member from the spinal construct to release the spinal construct from the selected configuration. Implants, surgical instruments, systems and methods are disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 2, 2019
    Assignee: Warsaw Orthopedic. Inc.
    Inventors: Joshua W. Simpson, William Alan Rezach, Richard Quinn Brown, Rodney R. Ballard
  • Patent number: 10293082
    Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 21, 2019
    Assignee: Clemson University Research Foundation
    Inventors: Leslie Sierad, Eliza Laine Shaw, George Fercana, Dan Simionescu
  • Patent number: 10258466
    Abstract: Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: April 16, 2019
    Assignee: Millipede, Inc.
    Inventors: Randall Lashinski, Matthew Rust, Patrick Macaulay, Richard Glenn
  • Patent number: 10251748
    Abstract: Embodiments hereof relate to centering devices for use with a valve delivery system and methods of delivering a valve prosthesis within a vasculature. A valve centering catheter is configured for use with a valve delivery system. The valve centering catheter includes a circumferential centering device at a distal portion thereof, and the circumferential centering device defines a central opening there-through when in an expanded configuration. The circumferential centering device is annular or has a C-shaped cross-section. The valve delivery system is tracked through the vasculature until the valve prosthesis is positioned through the central opening of the expanded circumferential centering device. The valve centering catheter may alternatively include a longitudinal centering device which acts as a marker for depth control during delivery of a valve delivery system, which may include an integral circumferential centering device.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 9, 2019
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Constantin Ciobanu, Niall Duffy, Frank White
  • Patent number: 10226332
    Abstract: A prosthetic heart valve includes a stent extending in a longitudinal direction, the stent being formed of a plurality of struts forming cells and having a plurality of commissure features, a collapsed condition and an expanded condition. A valve assembly may be secured to the stent, the valve assembly including a cuff and a plurality of leaflets. The cuff may be formed of a fabric and a second material different from the fabric, the cuff having commissure peaks and a plurality of midpeaks disposed between the commissure peaks. Each of the leaflets may have a free edge.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: March 12, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Kent J. Smith, Andrea L. McCarthy, Mina S. Fahim
  • Patent number: 10219900
    Abstract: This invention relates to a delivery apparatus and method for deployment of a mitral valve replacement.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: March 5, 2019
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli
  • Patent number: 10195023
    Abstract: A prosthetic heart valve includes a base and one or more heart valve leaflets. At least a portion of the leaflet including a composite material that contains a polymer substrate and a pre-stressed reinforcement element at least partially disposed in the polymer substrate.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Thomas A. Wrobel
  • Patent number: 10166014
    Abstract: A heart valve prosthesis (100) comprises a housing component (110) and a valve component (130). The housing component (110) comprises a housing body (111) having a housing passage (112) extending therethrough. The housing body (111) is configured to be located in, or adjacent to and communicating with, a native valve orifice (16) of a heart (10) and to engage structure of the heart (10) to fix the housing body (111) in relation to the valve orifice (161). The housing component (111) is collapsible for delivery via catheter (2). The valve component (130) comprises a valve body (131) having a valve passage (132) extending therethrough. The valve body (131) is configured to be fixed within the housing passage (112) with the valve passage (132) extending along the housing passage (112).
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: January 1, 2019
    Assignee: Percutaneous Cardiovascular Solutions Pty Ltd
    Inventors: Suku Thambar, Martin Christopher Cook, Stefan Schreck, Stayajit Rohan Jayasinghe
  • Patent number: 10154906
    Abstract: A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: December 18, 2018
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Juan F. Granada, Gary Erzberger, Michael P. Corcoran, Dan Wallace, Matteo Montorfano, Alaide Chieffo
  • Patent number: 10105217
    Abstract: Disclosed is a valve (502) for short time replacement, for taking over the function of and/or for temporary support of a native valve in a heart, the valve being positioned through the native valve upon implantation, the valve comprising an at least partially collapsible and/or at least partially expandable tube (602) and a flange (708). The valve allows for fast and easy replacement of a native valve, and more time for medical personnel to make decisions, prepare and/or perform surgery/medical intervention. Thus, the valve may provide for an improved quality of surgery/medical intervention.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: October 23, 2018
    Assignee: Medtentia International Ltd. Oy
    Inventor: Olli Keränen
  • Patent number: 10076403
    Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: September 18, 2018
    Assignee: V-Wave Ltd.
    Inventors: Neal Eigler, Lior Rosen, Werner Hafelfinger, Erez Rozenfeld, Tamir Ben-David, Nir Nae, Menashe Yacoby, Yaacov Nitzan
  • Patent number: 10076397
    Abstract: The invention relates to a device (1) and method for selecting the size and shape of a prosthesis and/or for determining the location of marks to be made on the external face of the skin of a patient intended to receive such a prosthesis, for example for repairing a hernia, comprising a sheet (2) of transparent material, the said sheet comprising: —a plurality of graphical representations (3a, 3b, 4a, 4b, 5a, 5b, 5c, 5d) concentrically embodying the respective outlines of various shapes and sizes of prosthesis, —a plurality of first holes (6a, 6b, 6c, 6d, 6e, 7a, 7b, 7c, 7d, 7e) arranged along the transverse line passing through the center of the said sheet, and—a plurality of second holes (8a, 8b, 8c, 8d, 8e, 8f, 8g, 9a, 9b, 9c, 9d, 9e, 9f, 9g) arranged along the longitudinal line passing through the center (C) of the said sheet.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: September 18, 2018
    Assignee: Sofradim Production
    Inventors: Sebastien Francois, Sebastien Ladet
  • Patent number: 10058421
    Abstract: A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 28, 2018
    Assignee: Medtronic, Inc.
    Inventors: Carol Eberhardt, Janice Shay
  • Patent number: 10034747
    Abstract: A two-component valve prosthesis system includes a docking component and a prosthetic valve component that is configured to be delivered separately from the docking component. The docking component has a compressed configuration for percutaneous delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The docking component includes a tubular skirt, a first annular scaffold attached to a first end of the tubular skirt and a second annular scaffold attached to a second end of the tubular skirt. The first and second annular scaffolds are independent from each other. An intermediate portion of the tubular skirt is unsupported such that neither of the first or second annular scaffolds surrounds the intermediate portion of the tubular skirt. The prosthetic valve component has a compressed configuration for percutaneous delivery within a vasculature and an expanded configuration for deployment within the intermediate portion of the docking component.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: July 31, 2018
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventor: Frank Harewood
  • Patent number: 9956078
    Abstract: Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: May 1, 2018
    Assignee: MITRALIX LTD.
    Inventor: Ira Yaron
  • Patent number: 9913714
    Abstract: A prosthesis is provided for implantation at a native semilunar valve of a native valve complex, the native valve complex having three semilunar sinuses and three native commissures. The prosthesis includes a valve prosthesis support, which comprises a support structure comprising exactly three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes. Upon implantation of the prosthesis, each of the engagement arms is at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to and in rotational alignment with a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 13, 2018
    Assignee: MEDTRONIC, INC.
    Inventors: Yossi Tuval, Raphael Benary, Ido Kilemnik
  • Patent number: 9895225
    Abstract: A collapsible valve prosthesis includes an armature and a set of prosthetic valve leaflets supported by the armature. The armature is expandable from a contracted condition to an expanded condition for anchoring at an annulus of a natural valve site, and includes a tubular intra-annular portion defining a blood flow lumen having an inflow side and an outflow side. The tubular intra-annular portion supports the prosthetic valve leaflets in the blood flow lumen and is provided with outward formations for coupling with the natural valve site. The armature includes an over-annular portion linked to the intra-annular portion to extend collar-like over the annulus of the natural valve site at the inflow side of the blood flow lumen. The armature may also include an under-annular portion to extend collar-like at the outflow side of the blood flow lumen. The prosthesis may permit mitral valve replacement (MVR) without removing the native valve leaflets and the chordae tendineae.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 20, 2018
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Giovanni Rolando, Paolo Gaschino, Antonella Orecchia, Monica Achiluzzi, Massimiliano Ares
  • Patent number: 9848983
    Abstract: Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: December 26, 2017
    Assignee: Millipede, Inc.
    Inventors: Randall Lashinski, Matthew Rust, Patrick Macaulay, Richard Glenn
  • Patent number: 9848981
    Abstract: A prosthetic heart valve includes at least one sealing member. The sealing member is adapted to conform to any surface irregularities found on the inner surface of the valve annulus, including any calcium deposits formed on the valve leaflets. The sealing member can be self-expanding or non-expanding. When deployed, the sealing member is adapted to create a blood tight seal between the prosthetic heart valve and the inner surface of the valve annulus thereby minimizing and/or eliminating perivalvular leakage at the implantation site.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: December 26, 2017
    Assignees: Mayo Foundation for Medical Education and Research, Sorin Group Italia S.r.l.
    Inventors: Rakesh M. Suri, W. Andrew Ziarno, Eric Manasse
  • Patent number: 9827091
    Abstract: A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent includes a plurality of cells, each cell being formed by a plurality of struts, and a plurality of commissure features. The heart valve further includes a valve assembly secured to the stent and including a cuff and a plurality of leaflets, each leaflet being attached to adjacent commissure features and to the stent struts and/or the cuff.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: November 28, 2017
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Xue Mei Li, Peter N. Braido
  • Patent number: 9763782
    Abstract: An apparatus for treating a heart valve in need thereof comprises a valve member, a connecting member, and an anchor member suitable for anchoring the apparatus. The valve member reversibly moves between an open position and a closed position to augment or replace the function of the native valve leaflets, thereby reducing valve regurgitation. Some embodiments include a stent that is positioned in the native heart valve with the valve member disposed therein.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: September 19, 2017
    Assignee: Edwards Lifesciences AG
    Inventor: Jan Otto Solem