Flexible Leaflet Patents (Class 623/2.12)
  • Patent number: 10531951
    Abstract: A prosthetic heart valve for an endoprosthesis used in the treatment of a stenotic heart valve and/or a heart valve insufficiency. The prosthetic heart valve comprises a plurality of leaflets (3,4,5) which are able to switch between their open and close position in response to the blood flow through the heart. The leaflets are attached into a collapsible wire valve frame involving a stent part (1) and a wire mesh part (2) that complement each other in many ways. The prosthetic valve comprises additional elements (6) for its correct positioning and stabilization.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: January 14, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventor: Konstantinos Spargias
  • Patent number: 10512537
    Abstract: A polymeric heart valve is disclosed which includes a valve body having a central axis and including a conduit extending along the central axis from an inflow end to an outflow end; and at least three flexible leaflets extending from the body into the conduit, each of the leaflets defining an attachment curve with the body. Respective pairs of leaflets each define a commissure located proximal the body. The at least three leaflets define a partially open position at rest, a fully open position deflecting away from the central axis during forward blood flow along a direction from the inflow end to the outflow end, and a closed position deflecting toward the central axis during reverse blood flow along a direction from the outflow end to the inflow end.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: December 24, 2019
    Assignee: ABIOMED, INC.
    Inventors: Scott C. Corbett, Mike Finnegan, Stephen Vaughan, Jeffery Juretich
  • Patent number: 10492905
    Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 3, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
  • Patent number: 10433955
    Abstract: A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 8, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Peter G. Edelman, Scott Fisher, Huisun Wang, Richard Charles Gunderson, Horng-Ban Lin, Jeffrey S. Lindquist
  • Patent number: 10426609
    Abstract: A prosthetic heart valve includes a composite material that has a first plurality of fibers embedded in a polymer matrix. Each fiber can have a first extending direction and a plurality of undulations.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: October 1, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Peter G. Edelman, Joseph Thomas Delaney, Jr.
  • Patent number: 10327895
    Abstract: The invention relates to a medical prosthesis, and in particular a heart valve substitute comprising a pliant tubular conduit mounted on a resilient annular frame and tethered to a non-perforating anchor within the right or left ventricle of the heart, wherein the pliant tubular conduit is a reciprocating mechanical member that is compressed by pressurized working fluid within the ventricle during systole.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: June 25, 2019
    Assignee: VDYNE, LLC
    Inventors: Lucian Lozonschi, Georg Lutter
  • Patent number: 10266684
    Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: April 23, 2019
    Assignee: Colorado State University Research Foundation
    Inventors: Susan P. James, Hieu Bui
  • Patent number: 10154838
    Abstract: Devices and methods for treating or repairing a heart are disclosed. The device includes at least one radially expandable tissue-engaging element, an elongate member (e.g., suture) coupled to the expandable element, and a locking mechanism (e.g., locking clip, suture knot). The expandable element may be anchored to heart tissue within the heart, such as in the left ventricle, with the elongate member extending from the expandable element and across a heart chamber to a second location such as the heart apex where the elongate member is held by the locking mechanism.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: December 18, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventor: Jan Otto Solem
  • Patent number: 10105208
    Abstract: This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: October 23, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Robert Tranquillo, Zeeshan Syedain, Lee Meier
  • Patent number: 10076402
    Abstract: Systems and devices with an implantable, intravascular filter for preventing emboli from traveling into brain and causing a stroke or transient ischemic attack are disclosed. In particular, an implantable, intravascular device having a filter element, a pressure sensor, and a valve is disclosed. The valve is biased into a closed configuration and changes into an open configuration upon a predetermined pressure drop across the filter. Systems comprising an external device at least one implantable device are also disclosed.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: September 18, 2018
    Assignee: Cook Medical Technologies LLC
    Inventor: David D. Grewe
  • Patent number: 10022219
    Abstract: A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as a prosthetic heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer present in the pores of the porous expanded fluoropolymer.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: July 17, 2018
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Paul D. Gassler, Cody L. Hartman, Peter J. Walsh
  • Patent number: 9968447
    Abstract: Methods of preparing a sheet of bioprosthetic tissue for use as a prosthetic valve leaflet are disclosed. A method includes positioning a sheet of bioprosthetic tissue across an engagement face of a first patterned substrate. The engagement face defines a pattern having at least one raised region and areas of relief adjacent the at least one raised region. The tissue is compressed against the engagement face to deform the tissue to a deformed state corresponding with the pattern.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: May 15, 2018
    Assignee: Medtronic Vascular, Inc.
    Inventors: Laura McKinley, Benjamin Wong, Wei Wang, Elliot Howard, Tracey Tien, Karl Olney, Joshua Dudney
  • Patent number: 9839512
    Abstract: A prosthetic heart valve provided herein can include at least one leaflet having a body portion and two opposite sleeve portions. The body portion can be defined by at least two side edges adjacent each sleeve portion. The at least one leaflet can define at least one notch between at least one of the two side edges and the adjacent sleeve portion, or at least one aperture positioned adjacent at least one side edge and an adjacent sleeve portion.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: December 12, 2017
    Assignee: Boston Scientific, Inc.
    Inventors: Andrew J. H. Backus, John Lin, Shannon Elizabeth Kozinn, Balvir K. Johal
  • Patent number: 9814575
    Abstract: A stentless support structure capable of being at least partly assembled in situ. The support structure comprises a braided tube that is very flexible and, when elongated, becomes very long and very small in diameter, thereby being capable of placement within a small diameter catheter. The support structure is preferably constructed of one or more thin strands of a super-elastic or shape memory material such as Nitinol. When released from the catheter, the support structure folds itself into a longitudinally compact configuration. The support structure thus gains significant strength as the number of folds increase. This radial strength obviates the need for a support stent. The support structure may include attachment points for a prosthetic valve.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: November 14, 2017
    Assignee: HLT, Inc.
    Inventors: Gary A. Thill, Robert Foster Wilson, John P. Gainor, Christopher M. Banick
  • Patent number: 9629716
    Abstract: Methods and apparatus are provided for repairing or replacing a defective cardiac valve including an anchor having a double helix configured to engage the cardiac valve leaflets of a diseased or defective cardiac valve, and a replacement valve body disposed in an expandable stent configured to be disposed within the anchor so that the anchor limits expansion of the expandable stent. The expandable stent of the replacement valve body may be self-expanding or mechanically expanded, e.g., using a balloon catheter or catheter-based mandrel and the valve body may be formed of animal tissue or a synthetic fabric.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 25, 2017
    Assignee: BMEYE B.V.
    Inventor: Jacques Seguin
  • Patent number: 9597181
    Abstract: A prosthetic heart valve can include an outer support assembly, an inner valve assembly, which define between them an annular space, and a pocket closure that bounds the annular space to form a pocket in which thrombus can be formed and retained. Alternatively, or additionally, the outer support assembly and the inner valve assembly can be coupled at the ventricle ends of the outer support assembly and the inner valve assembly, with the outer support assembly being relatively more compliant in hoop compression in a central, annulus portion than at the ventricle end, so that the prosthetic valve can seat securely in the annulus while imposing minimal loads on the inner valve assembly that could degrade the performance of the valve leaflets.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 21, 2017
    Assignee: Tendyne Holdings, Inc.
    Inventors: Mark Christianson, Chad Perrin, Zachary Tegels, Craig Ekvall, Robert Vidlund, Son Mai, Michael Evans
  • Patent number: 9572667
    Abstract: Devices and methods for treating or repairing a heart are disclosed. The device includes at least one radially expandable tissue-engaging element, an elongate member (e.g., suture) coupled to the expandable element, and a locking mechanism (e.g., locking clip, suture knot). The expandable element may be anchored to heart tissue within the heart, such as in the left ventricle, with the elongate member extending from the expandable element and across a heart chamber to a second location such as the heart apex where the elongate member is held by the locking mechanism.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: February 21, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventor: Jan Otto Solem
  • Patent number: 9554902
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end. The heart valve further includes a plurality of commissure features disposed on the stent, and a collapsible and expandable valve assembly, the valve assembly including a plurality of leaflets connected to the plurality of commissure features, each of the plurality of leaflets having a free edge and being configured to have a tension line aligned near the free edge to prevent backflow.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: January 31, 2017
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter Nicholas Braido, Katherine A. Ahmann, Mina Safwat Fahim, Jeffrey J. Allison, Andrea L. McCarthy
  • Patent number: 9504564
    Abstract: A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: November 29, 2016
    Assignee: Medtronic Corevalve LLC
    Inventors: Than Nguyen, Hung Nguyen, MyKim Nguyen, Stanley Komatsu, Robrecht Michiels
  • Patent number: 9504565
    Abstract: Described embodiments are directed toward prosthetic valves having leaflets that move asymmetrically in that a leaflet second side region of the leaflet initially moves toward the open position before a leaflet first side region and the leaflet first side region initially moves toward the closed position before the leaflet second side region. In the fully open position, the leaflet first side region opens less than the leaflet second side region. Asymmetric opening and final open position, in synchrony with the other leaflets having the same motion and final open position creates spiral flow exiting the open valve that increases blood flow on the downstream side of the leaflet and thus reduces stagnation of the blood that might lead to thrombus formation. Controlled asymmetric movement of the leaflet reduces closing volume by initiating closure on the leaflet first side region and finishing closures on the leaflet second side region.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: November 29, 2016
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: Joseph R. Armstrong
  • Patent number: 9416783
    Abstract: The invention relates to a rotor for a fluid pump, in particular for use in the medical sphere, the rotor being compressible for bringing to the place of use and thereafter being expandable. The compressibility is assisted by the provision of cavities, in particular also production of the rotor at least partially from a foam.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: August 16, 2016
    Assignee: ECP ENTWICKLUNGSGELLSCHAFT MBH
    Inventors: Joerg Schumacher, Mario Scheckel, Henning Schlicht
  • Patent number: 9358109
    Abstract: A transcorporeal delivery system and method provide the ability to perform minimally invasive valve replacement surgery. The transcorporeal delivery system provides a device and method for transcorporeal (traversing the body surface) low profile delivery of a replacement valve, intracorporeal (inside the body) stabilization for suture placement, and minimal change to current valve replacement surgical implantation techniques.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: June 7, 2016
    Inventor: Vinay Badhwar
  • Patent number: 9180009
    Abstract: The invention relates to a system for testing heart valve leaflets. The system includes a leaflet support assembly with a support post for receiving and supporting a leaflet to be tested, the post being disposed in a target region of the support assembly. The system also has a transmitter assembly that includes a light source and is configured and arranged to direct light from the light source onto the target region. The system further includes a receiver assembly that has an image sensor configured and arranged to sense an image of the target region and generate image information indicative of the sensed image, such as leaflet droop.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: November 10, 2015
    Assignee: Medtronic, Inc.
    Inventors: Carolyn Majkrzak, Roger Lee, Kshitija Garde, Eric Richardson, Benjamin Wong
  • Patent number: 9056006
    Abstract: A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: June 16, 2015
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Peter Edelman, Horng-Ban Lin, Scott Fisher, Jeffrey S. Lindquist, Huisun Wang, Richard C. Gunderson
  • Patent number: 9034032
    Abstract: Devices and methods for implantation at a native mitral valve having a non-circular annulus and leaflets. One embodiment of the device includes a valve support having a first region configured to be attached to a prosthetic valve with a plurality of prosthetic leaflets and a second region. The device can further include an anchoring member having a longitudinal dimension and including a first portion configured to contact tissue at the non-circular annulus, a second portion configured to be attached to the valve support, and a lateral portion between the first portion and the second portion. The second portion of the anchoring member is attached to the second region of the valve support while in a low-profile configuration in which the anchoring member and the valve support are configured to pass through vasculature of a human. The lateral portion is transverse to the longitudinal dimension.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: May 19, 2015
    Assignee: Twelve, Inc.
    Inventors: Matt McLean, John Morriss, Hanson Gifford, III
  • Patent number: 9034033
    Abstract: Devices and methods for implantation at a native mitral valve having a non-circular annulus and leaflets. One embodiment of the device includes a valve support having a first region configured to be attached to a prosthetic valve with a plurality of prosthetic leaflets and a second region, and an anchoring member having a longitudinal dimension with a first portion configured to contact tissue at the non-circular annulus, a second portion configured to be attached to the valve support, and a lateral portion transverse to the longitudinal dimension between the first portion and the second portion. The anchoring member and the valve support are configured to move from a low-profile configuration to an expanded configuration in which a shape of the first region of the valve support is at least partially independent of a shape of the first portion of the anchoring member.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: May 19, 2015
    Assignee: Twelve, Inc.
    Inventors: Matt McLean, John Morriss, Hanson Gifford, III
  • Patent number: 9011525
    Abstract: A heart valve prosthesis includes a collapsible stent and a one-piece multi-leaflet valve. The stent includes at least one length of wire having a series of turns forming a spring-like stent. The one-piece multi-leaflet valve is attached to the stent and includes a cylinder of polyester material secured thereto at three points. The stent is collapsible in a radial direction between a contracted state and an expanded state. The contracted state has a radial dimension smaller than a radial dimension of the expanded state. The stent is spring biased toward the expanded state such that it occupies an active state when implanted into a heart. The active state has a radial dimension that is between the radial dimension of the contracted state and the radial dimension of the expanded state such that a radial load generated by the bias of the collapsible stent is sufficient to retain the heart valve prosthesis in the heart.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: April 21, 2015
    Assignee: The Florida International University Board of Trustees
    Inventors: Thomas E. Claiborne, III, Richard T. Schoephoerster, Siobhain L. Gallocher
  • Patent number: 9011527
    Abstract: A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent includes a plurality of cells, each cell being formed by a plurality of struts, and a plurality of commissure features. The heart valve further includes a valve assembly secured to the stent and including a cuff and a plurality of leaflets, each leaflet being attached to adjacent commissure features and to the stent struts and/or the cuff.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: April 21, 2015
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: XueMei Li, Peter Nicholas Braido
  • Patent number: 8992605
    Abstract: In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: March 31, 2015
    Assignee: Edwards Lifesciences AG
    Inventors: Avraham Zakai, David Mishaly, Dan Rottenberg, David Alon
  • Publication number: 20150088250
    Abstract: A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 26, 2015
    Inventors: Qinggang Zeng, Derrick Johnson, Van Le Huynh
  • Publication number: 20150088251
    Abstract: Provided herein is a prosthetic device in patients with ventricular assist device (VAD) support and a closed off aortic valve orifice, which reestablishes the formation of normal fluid flow patterns in the aortic root. The prosthesis includes a circular body having a first surface and a second surface and a projection disposed on the first surface of the body, wherein the projection includes a plurality of walls extending away from the first surface of the body, each wall being positioned such that a first side edge contacts a center of the body, thereby forming a plurality of intercepted arcs, each located between adjacent walls; and a plurality of concave parabolic surfaces, each disposed within an intercepted arc. Also provided are methods of using the prosthetic device to reduce thrombosis formation in patients with VAD support.
    Type: Application
    Filed: September 18, 2014
    Publication date: March 26, 2015
    Applicant: San Diego State University Research Foundation
    Inventor: Karen May-Newman
  • Patent number: 8986374
    Abstract: Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: March 24, 2015
    Assignee: Edwards Lifesciences Corporation
    Inventors: Hengchu Cao, Brian Conklin, Paul Schmidt, Grace Myong Kim, James A. Davidson, Hoa Trinh Tran, Kristy Luong Tam
  • Publication number: 20150073541
    Abstract: A method for percutaneously replacing a heart valve of a patient. In some embodiments the method includes the steps of percutaneously delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; expanding the anchor to a deployed configuration in which the anchor contacts tissue at a first anchor site; repositioning the anchor to a second anchor site; and deploying the anchor at the second anchor site.
    Type: Application
    Filed: September 18, 2014
    Publication date: March 12, 2015
    Applicant: Sadra Medical, Inc.
    Inventors: Amr Salahieh, Brian D. Brandt, Dwight P. Morejohn, Ulrich R. Haug, Jean-Pierre Dueri, Hans F. Valencia, Robert A. Geshlider, Jeff A. Krolik
  • Patent number: 8961593
    Abstract: A heart valve that can be expanded following its implantation in a patient, such as to accommodate the growth of a patient and the corresponding growth of the area where the valve is implanted, and to minimize paravalvular leakage. In one aspect, the invention may maximize the orifice size of the surgical valve. The invention includes expandable implantable conduits and expandable bioprosthetic stented valves. In one aspect of the invention, the valve may be adapted to accommodate growth of a patient to address limitation on bioprosthetic valve lifespans.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: February 24, 2015
    Assignee: Medtronic, Inc.
    Inventors: Philipp Bonhoeffer, Timothy R. Ryan
  • Patent number: 8961599
    Abstract: A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. In one aspect, the composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes a porous expanded fluoropolymer membrane and an elastomer, wherein the elastomer fills substantially all of the pores of the porous expanded fluoropolymer, and the composite material comprising less than about 80% fluoropolymer by weight.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: February 24, 2015
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Paul D. Gassler, Cody L. Hartman, Peter J. Walsh, Charles F. White
  • Publication number: 20150045879
    Abstract: Synthetic chord devices and methods for using the same for connecting tissues are provided. Aspects of the synthetic chord devices include a first flexible connector having first and second ends. Located at the first end is an attachment element that includes a piercing member coupled to a securing member, wherein the securing member transitions from a linear to a planar configuration upon separation of the piercing member from the attachment element. A reinforcing element is located at the second end. The devices and methods of the invention find use in a variety of applications, such as cardiac valve, e.g., mitral valve repair; or tissue closure.
    Type: Application
    Filed: July 25, 2014
    Publication date: February 12, 2015
    Inventors: James Longoria, Roy Chin
  • Patent number: 8945212
    Abstract: A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: February 3, 2015
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Paul D. Gassler, Cody L. Hartman, Peter J. Walsh
  • Patent number: 8876897
    Abstract: In accordance with one embodiment of the present disclosure, a prosthetic valve is provided. The prosthetic valve includes an annulus, a pair of leaflets, and a pair of support elements. The annulus has a generally saddle-shape formed by a movable pair of first portions separated from each other by a movable pair of second portions. The pair of leaflets extend from the annulus and are separated from each other by the pair of support elements. The first portions of the annulus and the second portions of the annulus are configured to move back and forth from being generally concave to being generally convex such that any movement of the first portions of the annulus occurs at generally the same time as any movement of the second portions of the annulus.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: November 4, 2014
    Inventor: Arash Kheradvar
  • Publication number: 20140277408
    Abstract: In at least one embodiment, a prosthetic valve assembly comprises a pouch connecting two valves to one another. The valve assembly is delivered by a catheter system. In some embodiments, the valve assembly includes a valve for replacing a mitral valve and a valve for replacing an aortic valve. The valve assembly may optionally include an adhesive layer on the outer surface.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: Martyn G. Folan
  • Patent number: 8771345
    Abstract: A prosthesis including a distal fixation member that defines two or more engagement arms that are configured to apply a first axial force to tissue of the subject on a downstream side of the native valve complex. The prosthesis also includes a proximal fixation member configured to apply a second axial force to tissue of the subject on an upstream side of the native valve complex such that application of the first and second axial forces couples the prosthesis to the native valve complex. The proximal fixation member and the distal fixation member are fabricated as one integrated structure. The engagement arms and the proximal fixation member are configured to capture leaflets of the native valve complex therebetween without folding over of leaflets of the native valve complex, upon implantation of the prosthesis.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: July 8, 2014
    Assignee: Medtronic Ventor Technologies Ltd.
    Inventors: Yosi Tuval, Ido Kilemnik, Raphael Benary
  • Publication number: 20140180399
    Abstract: Described is a heart valve leaflet manufactured from a mesh material. The mesh material may have an ability to capture circulatory/stationary/migratory cells of the body to become biologically active. In some cases, the mesh material is coated with a bioactive material, such as a molecule that binds to a cell adhesion molecule (CAM), a growth factor, an extracellular matrix molecule, a subendothelial extracellular matrix molecule or a peptide. The mesh has a stiffness that is comparable to a native heart valve leaflet, such that it functionally mimics a native heart valve.
    Type: Application
    Filed: January 23, 2014
    Publication date: June 26, 2014
    Applicant: The Regents of the University of California
    Inventors: Seyedhamed Alavi, Arash Kheradvar
  • Publication number: 20140180402
    Abstract: A leaflet for a prosthetic valve formed of at least one layer that includes a composite material containing at least one expanded fluoropolymer membrane having serpentine fibrils and an elastomer is provided. The fluoropolymer may be polytetrafluoroethylene. In at least one embodiment, the elastic properties are present in an axial direction the leaflet. The leaflets may be single layered or multi-layered. The leaflets may be coupled to a support structure and movable between open and closed configurations relative to the support structure to form a heart valve. The elasticity within the leaflets permits, among other things, the leaflets to bend with a reduced occurrence of wrinkles as the valve opens and closes. The elastic properties of the leaflet also, among other things, improve bending properties and reduce closure stresses, thereby extending the life of the leaflet.
    Type: Application
    Filed: February 17, 2014
    Publication date: June 26, 2014
    Applicant: W. L. GORE & ASSOCIATES, INC.
    Inventors: William C. Bruchman, Charles F. White
  • Publication number: 20140172082
    Abstract: Described embodiments are directed toward prosthetic valve leaflets of particular configurations that control bending character. In embodiments provided herein, a valve leaflet is provided with a planar zone that is bounded at a planar zone base by a straight line, wherein the leaflet is operable to bend along a base of the planar zone.
    Type: Application
    Filed: April 24, 2013
    Publication date: June 19, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventor: W. L. Gore & Associates, Inc.
  • Publication number: 20140172078
    Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve comprises a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape substantially that of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base, and wherein each of the two side regions have a shape substantially that of a triangle and each are defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 19, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventor: W. L. Gore & Associates, Inc.
  • Publication number: 20140163671
    Abstract: The present invention provides a leaflet for use in a prosthetic valve that stabilizes the motion of the leaflet as it moves between a closed position and an open position. In accordance with embodiments, a prosthetic valve is provided with a leaflet that contains a stiffening element between layers of film from which the leaflet is made.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 12, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Cody L. Hartman
  • Patent number: 8747460
    Abstract: A method for implanting a valve prosthesis at a native cardiac valve complex of a subject comprises implanting a distal fixation member of the valve prosthesis downstream of a native valve of the native valve complex such that two or more engagement arms of the distal fixation member apply, to a downstream side of the native valve, a first axial force directed upstream. The method also comprises implanting a proximal fixation member of the valve prosthesis at least partially upstream of the native valve, such that the proximal fixation member applies, to an upstream side of the native valve, a second axial force directed downstream, such that application of the first and second forces couples the valve prosthesis to the native valve complex. The engagement arms and the proximal fixation member capture leaflets of the native valve therebetween without folding over leaflets of the native valve.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: June 10, 2014
    Assignee: Medtronic Ventor Technologies Ltd.
    Inventors: Yosi Tuval, Ido Kilemnik, Raphael Benary
  • Publication number: 20140155989
    Abstract: Synthetic chord devices and methods for using the same for connecting tissues are provided. Aspects of the synthetic chord device include a flexible cord having an attachment element at both a first and a second end, wherein each attachment element includes a piercing member coupled to a securing member that attaches the flexible cord to a first tissue. At least a portion of the flexible cord can be configured to be secured to a second tissue. Aspects of the invention also include sets of the synthetic chord device with pre-measured flexible cords. The devices and methods of the invention find use in a variety of applications, such as in is applications in which it is desired to repair a heart valve.
    Type: Application
    Filed: May 15, 2013
    Publication date: June 5, 2014
    Inventor: James Longoria
  • Patent number: 8740974
    Abstract: A method of treating a diseased cardiac valve can include implanting a valve prosthesis by compressing the valve prosthesis to a compressed state for delivery and expanding the valve prosthesis to an expanded state for deployment. The valve prosthesis can include a valve fixation device having a plurality of struts, a first circumferential row of cells coupled to the struts, and a second circumferential row of cells coupled to the struts. The struts are substantially rigid such that the struts do not change dimensions between the compressed state and the expanded state. The valve prosthesis can also include a plurality of leaflets and a plurality of commissures. The valve is coupled to the valve fixation device such that the commissures are radially aligned with respective struts of the plurality of struts.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 3, 2014
    Assignee: Medtronic, Inc.
    Inventors: Gregory H. Lambrecht, John Liddicoat, Robert Kevin Moore
  • Publication number: 20140128960
    Abstract: Disclosed herein are heart valves made from a polymeric material, such as silicone. Specifically exemplified are heart valve embodiments made from a one or two-pieces of material, or which have low thrombogenic potential. Also disclosed are methods of fabricating such valves. Furthermore, also disclosed are systems for testing performance of heart valves.
    Type: Application
    Filed: March 12, 2012
    Publication date: May 8, 2014
    Inventors: Hitomi Greenslet, Faris M. Al-Mousily, Abdullah A. Kendoush
  • Publication number: 20140121766
    Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: SADRA MEDICAL INC.
    Inventors: Amr Salahieh, Brian D. Brandt, Dwight P. Morejohn, Ulrich R. Haug, Jean-Pierre Dueri, Hans F. Valencia, Robert A. Geshlider