Adjustable Patents (Class 623/2.37)
  • Patent number: 11986390
    Abstract: Solutions for reducing irritation and/or trauma which may result upon contact of an implanted implantable device with tissue surrounding or adjacent to the implantable device. Various embodiments include features which allow a tangential or otherwise atraumatic contact of the implantable device with the tissue, in contrast with a sharper contact which may occur with prior art implantable devices. The broad principles are applicable to annuloplasty devices, and have other broader applications as well.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: May 21, 2024
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Padraig J. Savage, Michael Lee, Matthew Rust, Joshua Mark Inouye, Levi Wolterstorff, Graham Krumpelmann
  • Patent number: 11986202
    Abstract: An endoluminal punch and introducer sheath are described wherein the endoluminal punch comprises a guidewire lumen through which a user is capable of placing a guidewire. The endoluminal punch system further comprises a mechanism affixed to the hub which is capable of controlling the axial positioning of the guidewire relative to the endoluminal punch distal end. The control mechanism can be released so that the endoluminal punch can be removed from a patient while retaining the guidewire in place within the patient. The endoluminal punch introducer, including a sheath and dilator, can comprise energy emitting electrodes or transducers for cutting larger size holes in stubborn (friable, scarred, or fibrotic) tissue. In other embodiments, the endoluminal punch can comprise a guidewire or stylet, wherein the guidewire or stylet is capable of emitting energy to cut through tissue.
    Type: Grant
    Filed: May 9, 2023
    Date of Patent: May 21, 2024
    Assignee: Indian Wells Medical, Inc.
    Inventors: Jay Alan Lenker, James Alexander Carroll, Eugene Michael Breznock, Donald J. Kolehmainen, Peter van der Sluis
  • Patent number: 11963873
    Abstract: Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: April 23, 2024
    Assignee: Medtronic, Inc.
    Inventors: Jason Quill, Cynthia Clague, Michael Green, Alexander J. Hill, Ana Menk, Paul Rothstein, Georg Bortlein
  • Patent number: 11925558
    Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: March 12, 2024
    Assignee: The United States of America, As Represented By The Secretary, Department of Health and Human Services
    Inventors: June-Hong Kim, Robert J. Lederman, Ozgur Kocaturk
  • Patent number: 11903827
    Abstract: This document provides devices and methods for the treatment of heart conditions. For example, this document provides prosthetic heart valves and transcatheter heart valve replacement methods. The prosthetic heart valves can be configured into a low-profile configuration for containment within a small diameter delivery sheath. The prosthetic heart valves include can include a valve member attached to a stent frame. In some embodiments, the valve member is a molded biomaterial with a novel shape and resulting performance characteristics. Localized protective covering members can be attached to the stent frame to prevent the valve member from contacting the stent frame as the valve member cycles between its open and closed configurations.
    Type: Grant
    Filed: April 10, 2023
    Date of Patent: February 20, 2024
    Assignee: Anteris Technologies Corporation
    Inventors: Jason Quill, William Leon Neethling, Christopher B. Brodeur, Ramji Iyer, Kaitlyn Roth
  • Patent number: 11883290
    Abstract: A clip for immobilizing leaflets of a cardiac or venous valve includes a hub having a pair of tangle resistant spring-biased outer arms coupled to an inferior end of the hub. A pair of tangle-resistant spring-biased inner arms lies adjacent to the outer arms and is coupled to a superior end of the hub. The clip may incorporate adjustable spacers and retrievable post implantation. A delivery catheter is used to position the valve clip adjacent a target valve while the outer and inner arms are biased in an opened position relative to each other. After the valve leaflets are located between the opened outer and inner arms, the biasing forces may be released to allow the clip to self-close over the valve leaflets.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: January 30, 2024
    Inventors: Raghuveer Basude, Shri Krishna Basude
  • Patent number: 11883283
    Abstract: A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular valve in a connection channel, having a circumferential connection channel wall structure, between atrial and ventricular chambers of a heart, including an inner device to be disposed in the interior of the connection channel, the inner device having a circumferential support structure which is radially expandable and having a valve attached to the circumferential support structure, and an outer device to be disposed on the exterior of the connection channel, wherein the outer device at least partly extends around the inner device at a radial distance to the inner device, wherein the inner and outer devices form a securing mechanism for securing the circumferential connection channel wall structure therebetween.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: January 30, 2024
    Assignee: HIGHLIFE SAS
    Inventor: Josef Weber
  • Patent number: 11877941
    Abstract: A method of implanting a prosthetic implant includes advancing a prosthetic implant into a patient's vasculature with a delivery apparatus, the delivery apparatus comprising a catheter and a control lead, the catheter including a lumen extending therethrough, the control lead extending through the lumen of the catheter, the prosthetic implant comprising an implant body, a seal extending radially outwardly from the implant body, and a locking bar coupled to the implant body and releasably coupled to the control lead, the locking bar radially offset relative to the central longitudinal axis of the implant body. The method further includes rotating the control lead of the delivery apparatus in a first direction relative to the catheter such that the locking bar rotates in the first direction relative to the implant body and the implant body expands radially from a first radially compressed state to a first radially expanded state.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: January 23, 2024
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Richard George Cartledge, John P. Cartledge
  • Patent number: 11872131
    Abstract: Embodiments of the present disclosure include a method for use at a native valve of a heart of a subject. At a distal portion of a delivery tool, a balloon is coupled to a shaft. The distal portion is advanced to the heart with an implant and the balloon disposed within a capsule. The implant includes a tubular frame and one or more shape-memory flanges. The tubular frame is compressed around the balloon, and the flanges are constrained within a downstream capsule-portion of the capsule. The flanges are exposed from the downstream capsule-portion such that the flanges automatically deflect radially outward. Subsequently, the flanges are pressed against a downstream surface of the native valve by moving the implant in an upstream direction. While the flanges are in contact with the downstream surface, the tubular frame is plastically expanded radially by inflating the balloon. Other embodiments are also described.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 16, 2024
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari, Meni Iamberger
  • Patent number: 11872133
    Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: January 16, 2024
    Assignee: University of Maryland, Baltimore; University of Maryland Medical System LLC
    Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
  • Patent number: 11864994
    Abstract: The present application relates to a separately releasable aortic valve stent, which includes a valve sewing segment, a positioning member, and a prosthetic valve. The prosthetic valve is connected to the valve sewing segment. The valve sewing segment and the positioning member are two independent components and connected to each other via a guiding device. The positioning member is able to be released prior to the valve sewing segment. A slide connection structure is disposed on the valve sewing segment. One end of the guiding device is connected to the positioning member, and another end of the guiding device passed through the slide connection structure is connected to the positioning member. The valve sewing segment is slidable along the guiding device.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: January 9, 2024
    Assignee: JENSCARE SCIENTIFIC CO., LTD.
    Inventors: Yibin Li, Linghe Zheng, Shiwen Lv
  • Patent number: 11845955
    Abstract: The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample. The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent and subsequently imaged.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: December 19, 2023
    Assignees: CASE WESTERN RESERVE UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)
    Inventors: Michael W. Jenkins, Yehe Liu
  • Patent number: 11839541
    Abstract: A prosthetic heart valve includes a valve ring, which includes metal segments, and which is cylindrical when in an expanded state. A valve ring fabric sleeve is coupled to the valve ring. A leaflet frame is disposed within the valve ring. A plurality of prosthetic leaflets are coupled to the leaflet frame. An upper skirt includes an upper skirt fabric, coupled to the valve ring fabric sleeve; and a flexible upper skirt frame, coupled to the upper skirt fabric such that the upper skirt fabric separates a downstream end of the upper skirt frame from an upstream end of the metal segments of the valve ring. When the prosthetic heart valve is in an expanded state, the upper skirt extends radially outward from the valve ring in an upstream direction and is configured to rest against an atrial surface of the heart. Other embodiments are also described.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: December 12, 2023
    Assignee: CARDIOVALVE LTD.
    Inventor: Gil Hacohen
  • Patent number: 11839538
    Abstract: The present disclosure relates to an arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve. With the method or the arrangement, leakage or regurgitation between a prosthetic heart valve and the surrounding valve tissue is prevented. In one embodiment, an arrangement for replacement or repair of a native heart valve is provided, which comprises a loop-shaped support 41 and a prosthetic heart valve 70 and wherein an outer segment 32 of the loop-shaped support 41 is positionable towards surrounding valve tissue of a native heart valve and wherein an outer surface 74 of the prosthetic heart valve 70 is positionable towards an inner segment 34 of the loop-shaped support 41 so as to prevent paravalvular leakage or regurgitation between the prosthetic heart valve 70 and the surrounding valve tissue of the native heart valve.
    Type: Grant
    Filed: May 2, 2021
    Date of Patent: December 12, 2023
    Assignee: HVR Cardio Oy
    Inventor: Olli Keränen
  • Patent number: 11832784
    Abstract: An annuloplasty implant comprises an elongate member, a plurality of anchors, and a gripper. The elongate member has a proximal end, and a distal portion that includes a distal end. The plurality of anchors are distributed along the elongate member. The elongate member extends proximally from a proximal-most anchor and through the gripper. The gripper comprises a locking element that, in a locked state, inhibits sliding of the elongate member through the gripper. An unlocker, disposed within the gripper, obstructs the locking element from assuming the locked state, and is pullable proximally out of the gripper. The gripper automatically assumes the locked state upon the unlocker being pulled proximally out of the gripper. A tool tensions the distal portion of the elongate member by pulling the elongate member proximally through the gripper while the unlocker obstructs the locking element from assuming the locked state. Other embodiments are also described.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: December 5, 2023
    Assignee: Edwards Lifesciences Innovation (Israel) Ltd.
    Inventors: Tal Sheps, Yaron Keidar, Yuval Zipory
  • Patent number: 11833035
    Abstract: Systems and methods for medical interventional procedures, including approaches to valve implantation. In one aspect, the methods and systems involve a modular approach to mitral valve therapy.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: December 5, 2023
    Inventors: Cyril J. Schweich, Jr., Todd J. Mortier
  • Patent number: 11806237
    Abstract: The present disclosure relates to methods, systems, subsystems, and kits for aligning an annuloplasty ring or a toroidal portion thereof with a natural fiducial in an annular target.
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: November 7, 2023
    Assignee: VALCARE, INC.
    Inventors: Yoav Rozen, Nadav Yellin, Shuki Porath, Yuri Falkovich
  • Patent number: 11793639
    Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. Such anchors can include deformable or collapsible structures upon tensioning of a bridging element in a lateral direction, or segmented tubes that can be adjusted by tightening of one or more tethers extending therethrough. Such anchors can be used as a posterior anchor in a blood vessel in implant systems having a tensioned bridging element extending between the posterior anchor and an anterior anchor deployed at another location within or along the body organ. Methods of deploying such anchors and use of multiple anchors or multiple bridging elements to a single anchor are also provided.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: October 24, 2023
    Assignee: MVRx, Inc.
    Inventors: Timothy R. Machold, David A. Rahdert, Robert T. Chang, Ganesh Manoharan
  • Patent number: 11779459
    Abstract: Apparatus and methods are described including a valve frame defining a frame aperture and at least one arm attached to a portion of the valve frame on a ventricular side of said frame aperture. The at least one arm is configured to extend radially from the portion of the valve frame such that a chord receiving surface of the arm is sized and shaped to deploy among a region of the chords of the native mitral valve. The arm is curved, with an interior of the arm facing a direction in which the valve frame is configured to be rotated during deployment of the prosthetic mitral valve apparatus within the native mitral valve and with the arm having a concavely rounded leading edge facing at least partially in a circumferential direction. Other applications are also described.
    Type: Grant
    Filed: June 16, 2021
    Date of Patent: October 10, 2023
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRA AND SVCS LTD
    Inventors: Ehud Raanani, Boris Orlov, Boaz Harari, Oded Meiri, Lichen Rozitsky
  • Patent number: 11766323
    Abstract: A vascular system includes a delivery apparatus and an endovascular device. The delivery apparatus including a catheter and a control lead. The control lead extends through a lumen of the catheter and is configured to be manipulated by a user. The endovascular device is releasably coupled to the delivery apparatus and includes an implant body, a seal extending radially outwardly from the implant body, and one or more tissue engaging elements. The seal is configured to contact native vascular tissue to reduce leakage between the native vascular tissue and the implant body. The tissue engaging elements are pivotable relative to the seal from a compressed state to an expanded state. In the compressed state, the tissue engaging elements are positioned so as to disengage the native vascular tissue. In the expanded state, the tissue engaging elements extend outwardly from the seal and are configured to engage the native vascular tissue.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: September 26, 2023
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Richard George Cartledge, John P. Cartledge
  • Patent number: 11744699
    Abstract: Prosthetic heart valve devices and associated methods for percutaneous heart valve replacement are disclosed herein. A transcatheter valve prosthesis configured in accordance herewith includes a frame having a valve support and one or more support arms coupled thereto. The one or more support arms are configured to extend from the second end of the valve support toward the first end when the valve prosthesis is in an expanded configuration. When deployed in the expanded configuration, the one or more support arms have a curvilinear shape, such as a substantially S-shape, that at least partially engages tissue at the native heart valve.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: September 5, 2023
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Scott Robertson, Elliot Howard
  • Patent number: 11730591
    Abstract: Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The valve repair device detachably connects the distal and proximal ends of the catheter.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: August 22, 2023
    Assignee: Cedars-Sinai Medical
    Inventors: Robert James Siegel, Lawrence E. Ong
  • Patent number: 11717404
    Abstract: Valve holders and introducers for delivering a prosthetic heart valve to an implant site are in various embodiments configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, such as a removable activator dial and a removable handle that prevent implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate passing of a prosthetic valve between adjacent ribs of a patient. Valve holders and introducers according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: August 8, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Brian S. Conklin, Derrick Johnson
  • Patent number: 11672660
    Abstract: Annuloplasty device for use on a posterior annulus of a mitral valve, which is deployable to the mitral valve by means of a vascular delivery device, such as a catheter, and positionable along the curvature of the annulus, including at least a first and a second branch, each configured to extend along at least a section of the annulus, with a first end and a second end, at least one guiding means for guiding the first and the second branches relative to one another, at least one fixing means for fixing the device to the annulus, and at least one anchor means arranged on each of the first and second branches, whereby the first and the second branches are movable relatively to one another, so that the anchor means engage with the annulus thereby pulling the annulus together when the first and second branches are moved in opposite directions.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: June 13, 2023
    Assignee: AVVIE GMBH
    Inventors: Werner Mohl, Ashly Shaji
  • Patent number: 11672655
    Abstract: Some embodiments described herein include a heart valve replacement system that may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, a prosthetic heart valve of the system includes structural features that securely anchor the prosthetic heart valve to the site of the native heart valve. Such structural features can provide robust migration resistance. In particular implementations, the prosthetic heart valves occupy a smaller delivery profile, thereby facilitating a smaller delivery catheter for advancement to the heart.
    Type: Grant
    Filed: November 23, 2022
    Date of Patent: June 13, 2023
    Assignee: Laplace Interventional Inc.
    Inventors: Ramji Iyer, Lucas Tradd Schneider, Gunnar Paul Askegaard
  • Patent number: 11648120
    Abstract: Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: May 16, 2023
    Assignee: Polares Medical Inc.
    Inventors: Alexander Khairkhahan, Michael D. Lesh
  • Patent number: 11648025
    Abstract: An endoluminal punch and introducer sheath are described wherein the endoluminal punch comprises a guidewire lumen through which a user is capable of placing a guidewire. The endoluminal punch system further comprises a mechanism affixed to the hub which is capable of controlling the axial positioning of the guidewire relative to the endoluminal punch distal end. The control mechanism can be released so that the endoluminal punch can be removed from a patient while retaining the guidewire in place within the patient. The endoluminal punch introducer, including a sheath and dilator, can comprise energy emitting electrodes or transducers for cutting larger size holes in stubborn (friable, scarred, or fibrotic) tissue. In other embodiments, the endoluminal punch can comprise a guidewire or stylet, wherein the guidewire or stylet is capable of emitting energy to cut through tissue.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: May 16, 2023
    Assignee: Indian Wells Medical, Inc.
    Inventors: Jay Alan Lenker, James Alexander Carroll, Eugene Michael Breznock, Donald J. Kolehmainen, Peter van der Sluis
  • Patent number: 11642221
    Abstract: An implant includes a frame comprising a tubular body formed by a plurality of interconnected struts that are manufactured to reduce stresses and strains resulting from component interaction during chronic use. At least a portion of a longitudinal corner of one or more struts of the frame may be chamfered, rounded, or otherwise modified to distribute stresses experienced at the strut corner throughout the strut body. Chamfering and/or rounding corners along at least a portion of a strut of the frame may reduce stresses on the frame caused by interactions between the frame and other components of the implant. The implant may be manufactured by cutting (e.g., laser cutting) a plurality of struts from a tubular metal alloy, polymer, or the like forming the tubular body, and softening at least a portion of an edge of the strut by cutting, grinding, and/or micro-blasting the edges of the corner.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 9, 2023
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Burns Doran, Kelsey Cooper, Graham Krumpelmann, Ted Pelzer, Joshua Mark Inouye, Mark McPhail
  • Patent number: 11617652
    Abstract: A tissue-engaging element has a distal portion configured to engage a portion of tissue of the heart. A guide member is reversibly coupled to the tissue-engaging element. An elongate implant has a distal end and a proximal end, at least the distal end being slidably coupled to the guide member. A tool is slidable along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the elongate implant, and (ii) the guide member is coupled to the tissue-engaging element, such that sliding of the tool along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the elongate implant, and (ii) the guide member is coupled to the tissue-engaging element, slides at least the distal end of the elongate implant toward the tissue-engaging element.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: April 4, 2023
    Assignee: Edwards Lifesciences Innovation (Israel) Ltd.
    Inventors: Tal Reich, Eran Miller, Tal Sheps
  • Patent number: 11571298
    Abstract: An implant includes a prosthetic valve and is transitionable from a compressed to an expanded state. The implant includes a frame assembly including a plurality of struts that collectively define an upstream-frame-assembly-perimeter at an upstream end of the frame assembly and a downstream-frame-assembly-perimeter at a downstream end of the frame assembly. The frame assembly includes a valve frame that defines a lumen, and one or more appendages disposed at and extending in a downstream direction from the downstream-frame-assembly-perimeter. A plurality of prosthetic leaflets are disposed within the valve frame lumen and facilitate one-way upstream-to-downstream fluid flow through the lumen. The implant includes a fabric and, in the expanded state of the implant, the fabric obscures the one or more appendages and defines a downstream perimeter of the fabric at a downstream end of the implant. Additional embodiments are described.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: February 7, 2023
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Meni Iamberger, Yelena Kasimov, Boaz Harari, Aviram Baum
  • Patent number: 11571307
    Abstract: Apparatus, systems, and methods are provided for percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer tube, an inner body member, and an anchor deployment system. The outer tube includes a plurality of windows and has an axis along its length. The internal body member includes a plurality of anchors formed perpendicular to the axis. The anchor deployment system selectively rotates the internal body member with respect to the axis of the outer tube. The rotation deploys the plurality of anchors through the plurality of windows.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: February 7, 2023
    Assignee: VALCARE, INC.
    Inventors: Nadav Yellin, Samuel M. Shaolian, Jeffrey P. Dumontelle
  • Patent number: 11534300
    Abstract: Disclosed herein are embodiments related to a method for performing a minimally invasive procedure, the method including delivering an annuloplasty ring in a linear shape using a delivery system. In some embodiments, the delivery of the annuloplasty ring may utilize a trans-septal approach or a trans-apical. In some embodiments, the delivery system may position the annuloplasty ring using a flexible stabilizing mechanism and/or activate one or more anchors to extend outward from the annuloplasty ring.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: December 27, 2022
    Assignee: VALCARE, INC.
    Inventors: Nadav Yellin, Yoav Rozen, Samuel Shaolian, Shuki Porath, Troy Thronton, Guy Shimel
  • Patent number: 11523899
    Abstract: A coiled anchor is positioned at a mitral valve by extending and deflecting a catheter such that a distal end portion of the catheter has a curved shape that is disposed in a left atrium and a distal end of the catheter is positioned near a commissure of the mitral valve. A ventricular portion of the coiled anchor is advanced from the catheter under the mitral valve at the commissure and into a left ventricle. An atrial portion of the coiled anchor is deployed in the left atrium by retracting the catheter off the atrial portion of the coiled anchor while maintaining the position of the ventricular portion of the coiled anchor in the left ventricle.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: December 13, 2022
    Assignee: Mitral Valve Technologies Sarl
    Inventors: Mark Chau, Alexander J. Siegel, Paul A. Spence, Landon H. Tompkins
  • Patent number: 11510769
    Abstract: Devices and methods for providing protection from embolisms and microembolisms in a subject undergoing catheter-based intravascular procedures. The embolic protection devices have an expandable support frame comprising U-shaped members and leg members which facilitate proper placements in a defective valve annulus. The filtering devices expand in the vessels and allow blood flow to continue through the vessels, thereby catching and removing debris of the flowing blood. Also disclosed are embolic protection devices for use with a sutureless valve prosthesis which is implanted via catheter-based methods.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 29, 2022
    Assignee: JC Medical, Inc.
    Inventor: Ji Zhang
  • Patent number: 11510780
    Abstract: A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: November 29, 2022
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Juan F. Granada, Gary Erzberger, Michael P. Corcoran, Dan Wallace, Matteo Montorfano, Alaide Chieffo
  • Patent number: 11508104
    Abstract: A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain a measurement value related to the shape of a heart valve in medical image data. The processing circuitry is configured to cause a display to display a numerical value related to the shape of an artificial valve to be placed for the heart valve.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: November 22, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Keisuke Miyaki, Yu Igarashi, Koichiro Kurita
  • Patent number: 11491008
    Abstract: An annuloplasty device is disclosed comprising first and second support rings having a coiled configuration, and respective first and second retention units, the first support ring transitions to the second support ring over a transition section, the transition section is adapted to be arranged at a commissure of the heart valve leaflets, the first and second support rings extend in respective first and second coil planes being essentially perpendicular to the central axis, the transition section bends at least partly along the central axis so that the first coil plane is separated a distance from the second coil plane along the central axis at the transition section.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: November 8, 2022
    Inventors: Olli Keränen, Hans-Reinhard Zerkowski, Johannes Jung, Jani Virtanen
  • Patent number: 11471280
    Abstract: An annuloplasty band and method of implantation. The band is shaped and sized to avoid the adjacent aortic valve structure and better protects against dehiscence along the muscular mitral annulus. The band is asymmetric and when implanted spans more around the side of the mitral annulus having the posterior commissure than the side with the anterior commissure. The band has a saddle shape with a posterior upward bow centered on a minor axis of the mitral annulus, and a span extending clockwise therefrom is longer than a span extending counter-clockwise. A set of rings may have different saddle profiles and different plan view shapes for different sized bands. A method includes implanting so that the band extends over the posterior leaflet and a short distance past the posterior commissure outside of the anterior leaflet.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: October 18, 2022
    Assignee: Edwards Lifesciences, LLC
    Inventor: David H. Adams
  • Patent number: 11452518
    Abstract: A suture construct includes, inter alia, a sheath and a flexible strand threaded through the sheath to configure the sheath in a circular or oblong shape. The suture construct may be utilized in various tissue reconstruction procedures. The suture construct can be connected to a second suture construct to form a surgical assembly.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: September 27, 2022
    Assignee: Arthrex, Inc.
    Inventors: Joshua Best, Tyler Esposito, Colin Baker, Arley Perez, III
  • Patent number: 11446139
    Abstract: A collapsible device, such as an annuloplasty ring or prosthetic heart valve, is configured to be collapsed prior to being introduced into a patient via minimally-invasive access points such as port holes or intercostal incisions. A holder is configured to hold the collapsible device, and to selectively collapse the device for introduction into the patient and then re-enlarge the device at the desired deployment site. Collapsible devices include devices that can hingedly fold about hinge lines, and devices that can elongate to form substantially spiral forms with reduced diameters.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: September 20, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Teodoro S. Jimenez, Mark M. Dehdashtian, Raffaele Mazzei
  • Patent number: 11446140
    Abstract: A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular valve in a connection channel, having a circumferential connection channel wall structure, between atrial and ventricular chambers of a heart, including an inner device to be disposed in the interior of the connection channel, the inner device having a circumferential support structure which is radially expandable and having a valve attached to the circumferential support structure, and an outer device to be disposed on the exterior of the connection channel, wherein the outer device at least partly extends around the inner device at a radial distance to the inner device, wherein the inner and outer devices form a securing mechanism for securing the circumferential connection channel wall structure therebetween.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: September 20, 2022
    Assignee: HIGHLIFE SAS
    Inventor: Josef Weber
  • Patent number: 11382748
    Abstract: A device for improving the function of a heart valve comprises a first loop-shaped support, which is configured to abut a first side of the heart valve. A first flange unit is may be configured as a fabric sleeve covering the loop-shaped support. A portion of the fabric sleeve forms a flange that is attached to the annulus when said first loop-shaped support is abutting said heart valve. The flange is provideable by folding at least a portion of said sleeve over itself for forming a double layer of opposing fabrics thereof, such that said sleeve comprises a flange portion extending from said first loop-shaped support configured to overlap a surface of and form a collar around, at least a portion of said annulus.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: July 12, 2022
    Inventors: Olli Keränen, Hans-Reinhard Zerkowski
  • Patent number: 11376124
    Abstract: Various systems, devices and methods associated with the placement of a dock or anchor (72) for a prosthetic valve (120). The anchor (72) may take the form of a helical anchor having multiple coils (104, 108) and/or a stent-like structure. Various methods include different levels of minimal invasive procedures for delivering the prosthetic valve anchor (72) and prosthetic valve (120), as well as tissue anchors for plication or other purposes to the native valve position in the heart (14).
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: July 5, 2022
    Assignee: Mitral Valve Technologies Sarl
    Inventors: Paul A. Spence, Landon H. Tompkins
  • Patent number: 11364120
    Abstract: An apparatus for augmenting the length of native chordae tendineae to restore physiological leaflet coaptation. The apparatus includes a delivery device having a lumen therein which at least partially houses a prosthetic cord. The prosthetic cord has a first end with a first clasp configured to attach to a native chordae tendineae and a second end with a second clasp configured to attach to the native chordae tendineae. The native chordae tendineae is severed between the first clasp and the second clasp, and the length of the prosthetic cord between the first clasp and the second clasp is adjusted until physiological leaflet coaptation is restored.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: June 21, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Jay Reimer
  • Patent number: 11357629
    Abstract: A method of treating diastolic heart failure includes implanting a cardiac implant in a heart of a subject diagnosed as suffering from diastolic heart failure. A superior portion of a flexible tether of the cardiac implant is anchored to one or more left-atrial sites of one or more walls of the left atrium. An inferior portion of the flexible tether is anchored to a site of a wall of a mid third of the left ventricle, of a wall of an apical third of the left ventricle, and/or of a papillary muscle of the left ventricle. As a result, the flexible tether reduces a volume of the left atrium during at least a portion of ventricular diastole of each cardiac cycle, thereby enhancing ventricular filling. Other embodiments are also described.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: June 14, 2022
    Assignee: RAINBOW MEDICAL LTD.
    Inventor: Yossi Gross
  • Patent number: 11259926
    Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 1, 2022
    Assignee: Transmural Systems LLC
    Inventors: Nasser Rafiee, Stuart MacDonald, Koosha Rafiee
  • Patent number: 11202709
    Abstract: Apparatus includes an implant including a flexible longitudinal member extending along a longitudinal length of the implant and a flexible contracting member extending alongside the longitudinal member and along the longitudinal length of the implant. The contracting member is configured to facilitate reduction of a perimeter of the implant by applying a contracting force to the longitudinal member in response to an application of force to the contracting member. The contracting member is disposed at a radially outer perimeter of the longitudinal member and configured to apply a pushing force to the longitudinal member responsively to the application of the force to the contracting member.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 21, 2021
    Assignee: Valtech Cardio Ltd.
    Inventors: Eran Miller, Amir Gross, Oz Cabiri, Iftah Beinart, Aviram Baum
  • Patent number: 11173029
    Abstract: A method for treating regurgitation of blood flow through a diseased heart valve is provided. The diseased heart valve including an annulus, an anterior valve leaflet, a posterior valve leaflet and a subvalvular apparatus. The method includes providing an apparatus comprising a substantially annular support member, at least one infra-annular support member securely connected thereto, and at least one anchoring element associated with the at least one infra-annular support member. The method further includes attaching the substantially annular support member to the annulus of the diseased heart valve and attaching proximal and distal ends of a prosthetic chordae tendineae to the at least one anchoring element and a papillary muscle, respectively, so that the papillary muscle is caused to move medially.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: November 16, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jose L. Navia
  • Patent number: 11166812
    Abstract: Various systems, devices and methods associated with the placement of a dock or anchor for a prosthetic valve. The anchor can take the form of an anchor having multiple coils. The distal end portion of the anchor can be spaced radially outwardly from the next adjacent coil to help direct the anchor around native leaflets of a native valve. Various methods include different procedures for delivering the anchor and prosthetic valve.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 9, 2021
    Assignee: Mitral Valve Technologies Sari
    Inventors: Paul A. Spence, Landon H. Tompkins
  • Patent number: 11147671
    Abstract: Disclosed herein are methods, implants and systems for treatment of mitral valve prolapse by subannular fixation of the prolapsed mitral valve. The disclosure relates generally to the field of heart valve repair devices, methods and kits and more specifically to trans catheter methods and devices for insertion of tethers and anchors to the mitral valve leaflets for reduction the prolapsed mitral valve and subannular fixation of the prolapsed leaflet to treat mitral valve regurgitation.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: October 19, 2021
    Assignee: CREATIVE HEART VALVE SOLUTIONS LLC
    Inventors: Valavanur A. Subramanian, Nirav C. Patel