Tissue Patents (Class 623/23.72)
  • Patent number: 10835635
    Abstract: A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of the natural polymer mixture is described. Use of an activating agent and a combination of the natural polymers is unique. The natural polymer tissue adhesive may be useful as a post-operative application for tonsillectomy or adenoidectomy surgery, as an internal tissue adhesive for surgery or wound repair or for application to a burn or skin donor site. For internal use, an optional treatment to improve resistance of the activated adhesive to body fluids is also described. The adhesive described not only functions as an adhesive but would also serve as a protective barrier when applied to surgery or skin sites. In addition, the natural polymers would promote healing due to the inherent properties of the polymers selected.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 17, 2020
    Assignee: HCS Innovation, LLC
    Inventors: Ronnie Michael Hanes, Adele Lamping Hanes
  • Patent number: 10835235
    Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 17, 2020
    Assignee: New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
    Inventor: Struan H. Coleman
  • Patent number: 10828391
    Abstract: Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: November 10, 2020
    Assignee: LifeCell Corporation
    Inventors: Wenquan Sun, Melissa Richter Bowley, Raghav Goel
  • Patent number: 10792145
    Abstract: In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (AHM) patch. In some embodiments, the method includes obtaining and/or isolating cells from a subject. In some embodiments, the cells are primary cardiac cells. In some embodiments, the method further includes forming a scaffold. In some embodiments, the method includes seeding the cells in the fibrin gel scaffold. In some embodiments, the method includes culturing the cells seeded in the fibrin gel scaffold under conditions appropriate for the formation of an artificial heart muscle (AHM) patch.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 6, 2020
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventor: Ravi K. Birla
  • Patent number: 10765506
    Abstract: A laminate useful as a component of a medical implant, for example, useful as a component of an inflatable tissue expander. The laminate includes a base layer, an intermediate layer, and a top layer. When used as a component of a tissue expander, the laminate enables an internal chamber pressure of about 2.5 psi with an expander exterior compressive force of about 40 lbs.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: September 8, 2020
    Assignee: Allergan, Inc.
    Inventors: Kaustubh S. Chitre, Nicholas Manesis, Nikhil S. Trilokekar, Dustin Leslie, David J. Schuessler
  • Patent number: 10765507
    Abstract: A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: September 8, 2020
    Assignee: Tepha, Inc.
    Inventors: Arikha Moses, Emily Stires, Anthony Natale
  • Patent number: 10758644
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron
  • Patent number: 10729508
    Abstract: A tissue expansion device with a plurality of lobes made from non-compliant material, each lobe defining a chamber therein. Each chamber is fluidly isolated from every other chamber in the plurality of lobes. Each chamber has an inflation element with a valve to release a pressurized fluid to inflate the lobe to expand a cavity, and a deflation element with a valve to deflate the lobe by compressing the fluid.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 4, 2020
    Assignee: Medtronic Advanced Energy LLC
    Inventors: Nathan Zamarripa, Mark Guirguis, Nicholas Valley
  • Patent number: 10722336
    Abstract: The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: July 28, 2020
    Assignee: NOVUS SCIENTIFIC AB
    Inventors: Torbjörn Mathisen, Anna Wistrand
  • Patent number: 10709538
    Abstract: The present invention relates to a prosthesis (200) comprising: one mesh (1) delimited by a peripheral exterior edge (1a), a frame (2) fastened to said mesh and adopting the shape of said peripheral exterior edge of the mesh, said frame being set back from said peripheral exterior edge and being provided with two hinge points (3a, 3b), the line passing through said two hinge points also passing through the centre (1b) of the mesh and thus forming a line M for folding the mesh in two, characterized in that said prosthesis further comprises at least two anchor pieces (5) made of suturable material and located on a single face of the mesh (1) on either side of said folding line, each piece having a fixed part (5a) linked to said mesh and a free part (5b), said free part being linked to at least one thread-shaped element (7).
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 14, 2020
    Assignee: SOFRADIM PRODUCTION
    Inventors: Pierre Bailly, Gaetan Romuald
  • Patent number: 10695463
    Abstract: Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 30, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Rachel McGuire, Ryan Borem, Jeremy Mercuri
  • Patent number: 10682145
    Abstract: Various aspects of the disclosure pertain to blood vessel occlusion devices having a central longitudinal axis and comprising: (a) a hub, (b) a self-expanding support frame comprising a plurality of wire segments forming a plurality of cells, and (c) a covering material covering cells within the transition portion. The support frame may be self-expandable from a constrained shape to an unconstrained shape that comprises (ii) a substantially cylindrical portion having a diameter and an axis that is coincident with the central longitudinal axis, the substantially cylindrical portion comprising a first ring of the cells extending in a 360° rotation around the central longitudinal axis and (ii) a transition portion disposed between the substantially cylindrical portion and the hub. Other aspects for the disclosure pertain to assemblies, kits and methods that employ such devices.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: June 16, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph Michael Connolly
  • Patent number: 10590388
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 17, 2020
    Assignees: UBE INDUSTRIES, LTD., KURUME UNIVERSITY
    Inventors: Keisuke Ohta, Shingo Hirashima, Masahiko Hagihara, Motohisa Shimizu
  • Patent number: 10561494
    Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic heart valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. The delivery apparatus in particular embodiments is configured to deploy a prosthetic valve from a delivery sheath in a precise and controlled manner at the target location within the body.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: February 18, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Jun Liu, Asher L. Metchik, Sergio Delgado
  • Patent number: 10532127
    Abstract: Methods to produce perforated collagen coated meshes for use as implants have been developed. The method involves positioning needles through the pores of the mesh, coating the mesh with a collagen solution, freezing the coated mesh, removing the needles from the frozen coated mesh, drying the collagen coated mesh, and optionally cross-linking the coated mesh. The method allows perforated collagen coated meshes to be prepared with variable thickness, and without damage to the surface of the mesh. The perforations of the collagen coated meshes may be designed to prevent the formation of fluid pockets when the coated meshes are implanted, and to permit rapid incorporation into host tissue. The perforated collagen coated meshes may be used for soft tissue repair, regeneration or remodeling including, for example, hernia repair, mastopexy, treatment of urinary incontinence, pelvic floor reconstruction, and ligament and tendon repair.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 14, 2020
    Assignee: Tepha, Inc.
    Inventors: Skander Limem, Bhavin Shah, Said Rizk
  • Patent number: 10512711
    Abstract: The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: December 24, 2019
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventor: Robert G Matheny
  • Patent number: 10507095
    Abstract: A device for the reconstruction of the rotator cuff including a flat element having at least two opposite ends and adapted to be connected to at least one of the damaged tendons of the rotator cuff of a patient at the ends; the flat element being entirely made of biodegradable and resorbable material.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: December 17, 2019
    Inventor: Antonio Sambusseti
  • Patent number: 10500031
    Abstract: An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. Each mesh extension is configured to permit multiple anchor points with surrounding tissue upon implantation. In one embodiment, a fixation device is at the second end of each mesh extension. Methods of using the implantable mesh are also provided.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 10, 2019
    Assignee: Duke University
    Inventor: Howard Levinson
  • Patent number: 10493180
    Abstract: Disclosed are composite implantable tissue attachment devices comprising a mechanical reinforcing component and a cellular scaffold component. Disclosed devices include a wide, relatively flat portion for supporting long term repair of tissue. Disclosed devices can include a tapered portion at the end of the wide portions that can lead into a narrower elongated extension for aiding in placement of the device during a surgical procedure. The wide portion of the device can provide tensile strength along the longitudinal axis of the device as well as porosity. The wide devices can cover a larger surface area of a delivery site than standard suture. Disclosed materials can be utilized in, e.g., soft tissue repair such as tendon and ligament reconstruction and repair.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: December 3, 2019
    Assignee: SYNOVIS LIFE TECHNOLOGIES, INC.
    Inventors: John Eric Brunelle, Al Weinstein
  • Patent number: 10478188
    Abstract: A staple cartridge assembly is disclosed which comprises a cartridge body and an implantable layer. The implantable layer includes fibers comprised of a first material and a second material. The first material and the second material have different glass transition temperatures. After the fibers comprised of the first material and the second material have been intermixed or interwoven, the layer is exposed to a temperature which exceeds the lower of the two glass transition temperatures. This heating process causes the layer to constrict and increase in thickness. The layer, when implanted, can compensate for variations in tissue thickness within the staples.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 19, 2019
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Frederick E. Shelton, IV, Michael J. Vendely, Susanne Landgrebe
  • Patent number: 10478281
    Abstract: An implantable prosthesis for mending anatomical defects, including a groin hernia. The prosthesis includes a prosthetic repair patch that may be implanted in different tissue planes to mend a defect. The patch may include a medial portion configured to be positioned in a first tissue plane and a lateral portion configured to be positioned in a second tissue plane offset from the first tissue plane. The patch may include a transition region configured to extend through tissue and/or muscle, such as fascia, separating the tissue planes and transition the patch from one tissue plane to the other tissue plane. The transition region may be configured to inhibit buckling and/or bunching of the patch when implanted through the fascia. The lateral portion of the patch may have a level of stiffness that facilitates implantation of the patch in different tissue planes while inhibiting patient sensation to the implanted patch.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: November 19, 2019
    Assignee: C.R. Bard, Inc.
    Inventors: Melissa Bowley, Devang Vijay Shah, Philip A. Tessier
  • Patent number: 10470887
    Abstract: Herein disclosed is a tissue supplied in a configuration pre-shaped to the topography of the recipient surface for covering defects in the articulating surfaces of bones. Also discussed herein is a method of preparing a graft for reconstruction of a defect in an articular surface of a bone comprising determining the topography of the native articular surface and the corresponding underside of the cartilage layer; fabricating a pair of mating surfaces having the topography of the native articular surface and the underside of the cartilage layer; harvesting a cartilage graft from a cadaveric donor; and placing said graft between the mating surfaces and subjecting said graft to sufficient pressure for a sufficient duration to cause it to change shape to that of the deforming surfaces.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: November 12, 2019
    Assignee: Institute of Orthopedic Research & Education
    Inventors: Hugh Jones, Philip C. Noble
  • Patent number: 10456131
    Abstract: An implant insertion device is adapted for use with a shape memory implant. The shape memory implant includes a bridge interconnecting first and second legs. The shape memory implant is movable between a first shape in which the first and second legs are substantially non-parallel and a second shape in which the first and second legs are substantially parallel. The implant insertion device engages the shape memory implant to maintain the shape memory implant in its second shape until the delivery of the shape memory implant into tissue or bone.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 29, 2019
    Assignee: BioMedical Enterprises, Inc.
    Inventors: Daniel F. Cheney, Joseph H. Taber, Luke A. Perkins, Joseph P. Ritz
  • Patent number: 10426586
    Abstract: A sacrocolpopexy support has a head section extending from a first end portion to a second end portion, and a leg section having a first leg portion placed on and in longitudinal alignment with a second leg portion. A first connector secures the leg section to the second end portion of the head section. A second connector secures the first leg portion to the second leg portion to form a closed joint that defines a space between the first leg portion and the second leg portion. An end of the second end portion of the head section terminates at a location exterior to the closed joint outside of the space between the first leg portion and the second leg portion.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 1, 2019
    Assignee: Coloplast A/S
    Inventors: Sarah J. Deitch, Michael M. Witzmann, John J. Allen, David Richmond, Matthew George Litton
  • Patent number: 10400217
    Abstract: The present invention relates to an immortalized cell, an immortalized cell line comprising said immortalized cell, a cell culture comprising the immortalized cell or cell line, and a method for the production of an immortalized cell.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 3, 2019
    Assignee: EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
    Inventor: Dorothea Alexander-Friedrich
  • Patent number: 10390946
    Abstract: A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: August 27, 2019
    Assignee: Biotronik AG
    Inventors: Nina Lehenberger, Alexander Rzany, Wilhelm Erdbruegger
  • Patent number: 10335516
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 2, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10314688
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: June 11, 2019
    Assignee: Arthrex, Inc.
    Inventors: David Shepard, Reinhold Schmeiding, Adam Anz, Steve Jordan, John Tokish
  • Patent number: 10314783
    Abstract: The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: June 11, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 10285699
    Abstract: A compressible adjunct has a first portion, a second portion, and a middle portion. The middle portion is disposed between the first portion and the second portion. The middle portion comprises a first pillar, a second pillar, and an interconnecting member. The first pillar and the second pillar extend substantially between the first portion and the second portion. The interconnecting member is configured to engage at least the first pillar and the second pillar. When the compressible adjunct is compressed by a force, the first pillar is configured to deflect a first deflection and the second pillar is configured to deflect a second deflection. The first deflection differs from the second deflection.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 14, 2019
    Assignee: Ethicon LLC
    Inventors: Michael J. Vendely, Frederick E. Shelton, IV, Jason L. Harris, Howell T. Goldrein, Robert S. Moir, Sofia Maria Consonni, Ismail Akram, Ashley D. Easter, Helen S. Latham
  • Patent number: 10271942
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 30, 2019
    Assignee: Arthrex, Inc.
    Inventors: John Tokish, David Shepard, Brian Dorn
  • Patent number: 10258504
    Abstract: A method of repairing a detached retina includes removing sub-retinal fluid from a location within the eye between the retinal tissue and an underlying support tissue, inserting a biocompatible elastomeric patch having encapsulated ferromagnetic particles into an interior of the eye through an incision of a sclera of the eye, positioning a magnetic source adjacent to an exterior surface of the eye such that the magnetic source is aligned with the detached retinal tissue, and drawing the removable elastomeric patch toward the detached portion of the retina with the magnetic source such that the detached retinal tissue is substantially maintained against underlying support tissue along an inner eye wall by magnetic attraction between the encapsulated magnetic particles of the removable elastomeric patch and the magnetic source.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 16, 2019
    Inventor: Richard Breazeale
  • Patent number: 10232081
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 19, 2019
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Patent number: 10201633
    Abstract: Compositions and methods for glass composites suitable for tissue augmentation, biomedical, and cosmetic applications are provided. The glass microsphere component of the composites are biologically inert, non-reactive and act as a nearly permanent tissue filler. One embodiment provides a tissue augmentation composite containing an effective amount of solid glass microspheres, hollow glass microspheres, porous wall hollow glass microspheres, or combinations thereof with a suitable biocompatible matrix to serve as a bulking agent when injected into a patient. The compositions can be used for soft or hard tissue augmentation as well as delivery of cargos on demand.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: February 12, 2019
    Assignees: Augusta University Research Institute, Inc., Applied Research Center, Inc.
    Inventors: Paul M. Weinberger, William D. Hill, George G. Wicks
  • Patent number: 10188495
    Abstract: A non-setting agent for positioning a surgical mesh prosthesis against a tissue defect during surgical hernia repair enables a surgeon to position the surgical mesh prosthesis at an optimal location against the tissue defect without pre-measuring suture location and pre-suturing. The surgical mesh prosthesis can be repositioned by removing and replacing, or by sliding, the mesh along the tissue defect without traumatizing the tissue. The positioning agent is provided with adhesion and lubricity characteristics providing an adhesion strength required to temporarily maintain the surgical mesh in place, otherwise unsupported, against tissue of a targeted tissue location, and providing a viscosity that permits removal and replacement, or slidable movement, of the surgical mesh along the tissue upon receipt of a non-gravitational external force applied to the surgical mesh so movement of the surgical mesh that is atraumatic to the tissue.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: January 29, 2019
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Roger Labrecque, Stephanie Santos
  • Patent number: 10071120
    Abstract: An osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is provided. The mixture is visible under X ray and remodels more easily than comparable mixtures of demineralized bone matrix and surface demineralized cortical bone chips. The osteoinductive implantable compositions comprises demineralized bone fibers in an amount from about 30 vol % to about 45 vol % and mineralized bone fibers in an amount from about 55 vol % to about 70 vol %. The osteoinductive implantable compositions can be delivered in delivery systems including mesh coverings for administration at surgical sites. A method of treating a bone defect caused by injury, disease, wounds, or surgery utilizing the osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is also provided.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: September 11, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Guobao Wei
  • Patent number: 10058410
    Abstract: The present invention relates to a prosthesis for inguinal hernioplasty made up of a surgical mesh extending from a first end (6) to a second end (7) along a longitudinal direction (A) and comprising a first portion (1) that includes said first end (6), a second portion (2) that includes said second end (7) and a connecting portion (3) arranged between said first portion (1) and said second portion (2), wherein said first portion (1) has a substantially ring shape that is or open or may be opened and is provided with a central hole (4), wherein said second portion (2) has a substantially elongated shape in said longitudinal direction (A), and wherein said connecting portion (3) has a width transverse to said longitudinal direction (A) smaller than the widths of said first portion (1) and said second portion (2) transverse to said longitudinal direction (A).
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 28, 2018
    Inventor: Angelo Guttadauro
  • Patent number: 10039627
    Abstract: In an embodiment, the invention discloses an implant that includes a first elongate member and a second elongate member formed monolithically with the first elongate member out of a single material and planar strip of material. The first elongate member includes a distal end portion and a proximal end portion. The second elongate member includes a first portion and a second portion. Further, each of the first portion of the second elongate member and the second portion of the second elongate member includes a proximal end portion and a distal end portion. The first portion and the second portion extend from the first elongate member. The distal end portion of the first elongate member is configured to be attached to or proximate a sacrum.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: August 7, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Michael S. H. Chu
  • Patent number: 10022473
    Abstract: A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: July 17, 2018
    Assignee: LifeCell Corporation
    Inventor: Wendell Sun
  • Patent number: 9993326
    Abstract: A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: June 12, 2018
    Assignee: Histogenics Corporation
    Inventors: Sonya Shortkroff, Laurence J. B. Tarrant, Eric J. Roos, Robert Lane Smith, Hans P. I. Claesson
  • Patent number: 9994975
    Abstract: Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 12, 2018
    Inventors: Deepthy Menon, John Joseph, Shantikumar Nair
  • Patent number: 9962251
    Abstract: A medical device assembly includes an implant having a support portion, and an arm portion and a dilator. The medical device assembly further includes a first suture having a first portion coupled to the arm portion of the implant, and a second portion coupled to the dilator. In addition, the assembly includes a second suture having a first portion coupled to the arm portion of the implant, and a second portion coupled to the dilator.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: May 8, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: James M. Goddard, Jamie Li
  • Patent number: 9951221
    Abstract: A thermally degradable polymeric fiber comprising a polymeric fiber matrix including a poly(hydroxyalkanoate) and a metal in the form of a compound selected from the group consisting of an alkaline earth metal oxide, a tin salt of a mono- or di-carboxylic acid, and scandium triflate (Sc(0Tf)3), where the concentration of the metal in the fiber matrix is at least 0.1 wt %.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: April 24, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Aaron P. Esser-Kahn, Hefei Dong, Piyush R. Thakre, Jason F. Patrick, Nancy R. Sottos, Jeffrey S. Moore, Scott R. White
  • Patent number: 9925030
    Abstract: Stitching patterns overlap to produce a corner-locked stitch pattern. The corner-locked stitch pattern includes one or more thread interlace points, and one or more overlays of threads from overlapping patterns. A network of corner-lock stitch patterns produces a mesh, which may be embroidered into a substrate, such as a medical textile or biotextile. Corner-lock stitch patterns resist puncture-induced and tension-induced deformation of mesh pores between corner-locked stitch patterns, and may be used to modulate compliance and enhance strength properties of a substrate into which they are sewn.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: March 27, 2018
    Assignee: TELA Bio, Inc.
    Inventors: Skott Greenhalgh, John-Paul Romano
  • Patent number: 9901601
    Abstract: Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 27, 2018
    Assignee: ADEKA CORPORATION
    Inventors: Akio Kishida, Seiichi Funamoto, Yoshihide Hashimoto, Jun Negishi, Souichiro Kuwa, Takao Ema, Kuniharu Kobayashi
  • Patent number: 9901659
    Abstract: A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: February 27, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yi Hong, Nicholas J. Amoroso, Kazuro Lee Fujimoto, Ryotaro Hashizume, William R. Wagner
  • Patent number: 9877820
    Abstract: The invention relates to a prosthesis (1) for the repair of an inguinal hernia comprising: a textile (2) of elongate shape, a resilient frame (3) connected to said textile, characterized in that said frame comprises a convex cranial segment (3c), a caudal segment (3d), a lateral corner segment (3b) joining together the convex cranial segment and the caudal segment, and a folding segment (5) joining a medial end of said convex cranial segment to a point located on the caudal segment while leaving the region of the medial end of the textile free of any frame, said frame being able to adopt an unstressed configuration, in which said textile is deployed, and a stressed configuration, in which said convex cranial segment, said caudal segment and said folding segment are substantially collected together and aligned on one folding direction, said textile forming thereby at least one fold along said folding direction.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 30, 2018
    Assignee: Sofradim Production
    Inventors: Pierre Bailly, Mylene Desorme, Genevieve Doucet
  • Patent number: 9820838
    Abstract: A novel single plane tissue repair device such as a patch is disclosed. The device has a base member with an opening therethrough, and a closure member associated with the opening. The mesh has a biaborbable polymeric adhesion barrier attached to the bottom side of the base member about its periphery to form a pocket that is accessible through the opening. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 21, 2017
    Assignee: Ethicon, Inc.
    Inventors: Xiaodong Liu, Michael Cardinale
  • Patent number: 9821500
    Abstract: In an apparatus for manufacturing a hybrid scaffold, a first strand having bin compatible polymer and a second strand having a mixture of bio compatible material and cells alternate with each other. Thus, mechanical strength of the hybrid scaffold is improved, and the cells uniformly grow among entire region of the scaffold. Furthermore, diameters of the first and second strands and interval between the first and second strands are precisely controlled. Thus, the hybrid scaffold is precisely manufactured according to a scaffold design.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 21, 2017
    Assignee: Korea Institute of Machinery & Materials
    Inventors: Junhee Lee, Sua Park, Wan-Doo Kim
  • Patent number: 9820843
    Abstract: Materials for soft tissue repair, and in particular, material for hernia repair. These materials may be configured as an implant, such as a graft, that may be implanted into a patient in need thereof, such as a patient having a hernia or undergoing a hernia repair surgical procedure. These grafts may include a first layer comprising a substrate (e.g., mesh) and a second layer comprising a sheet of anti-adhesive material. The layers may be attached with a plurality of relatively small attachment sites that are separated by regions in which the two layers are not attached, to provide a highly compliant graft.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 21, 2017
    Assignee: TELA Bio, Inc.
    Inventors: Skott Greenhalgh, John-Paul Romano, Travis Speicher