Tissue Patents (Class 623/23.72)
  • Patent number: 10456131
    Abstract: An implant insertion device is adapted for use with a shape memory implant. The shape memory implant includes a bridge interconnecting first and second legs. The shape memory implant is movable between a first shape in which the first and second legs are substantially non-parallel and a second shape in which the first and second legs are substantially parallel. The implant insertion device engages the shape memory implant to maintain the shape memory implant in its second shape until the delivery of the shape memory implant into tissue or bone.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 29, 2019
    Assignee: BioMedical Enterprises, Inc.
    Inventors: Daniel F. Cheney, Joseph H. Taber, Luke A. Perkins, Joseph P. Ritz
  • Patent number: 10426586
    Abstract: A sacrocolpopexy support has a head section extending from a first end portion to a second end portion, and a leg section having a first leg portion placed on and in longitudinal alignment with a second leg portion. A first connector secures the leg section to the second end portion of the head section. A second connector secures the first leg portion to the second leg portion to form a closed joint that defines a space between the first leg portion and the second leg portion. An end of the second end portion of the head section terminates at a location exterior to the closed joint outside of the space between the first leg portion and the second leg portion.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 1, 2019
    Assignee: Coloplast A/S
    Inventors: Sarah J. Deitch, Michael M. Witzmann, John J. Allen, David Richmond, Matthew George Litton
  • Patent number: 10400217
    Abstract: The present invention relates to an immortalized cell, an immortalized cell line comprising said immortalized cell, a cell culture comprising the immortalized cell or cell line, and a method for the production of an immortalized cell.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 3, 2019
    Assignee: EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET
    Inventor: Dorothea Alexander-Friedrich
  • Patent number: 10390946
    Abstract: A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: August 27, 2019
    Assignee: Biotronik AG
    Inventors: Nina Lehenberger, Alexander Rzany, Wilhelm Erdbruegger
  • Patent number: 10335516
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 2, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10314783
    Abstract: The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: June 11, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 10314688
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: June 11, 2019
    Assignee: Arthrex, Inc.
    Inventors: David Shepard, Reinhold Schmeiding, Adam Anz, Steve Jordan, John Tokish
  • Patent number: 10285699
    Abstract: A compressible adjunct has a first portion, a second portion, and a middle portion. The middle portion is disposed between the first portion and the second portion. The middle portion comprises a first pillar, a second pillar, and an interconnecting member. The first pillar and the second pillar extend substantially between the first portion and the second portion. The interconnecting member is configured to engage at least the first pillar and the second pillar. When the compressible adjunct is compressed by a force, the first pillar is configured to deflect a first deflection and the second pillar is configured to deflect a second deflection. The first deflection differs from the second deflection.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 14, 2019
    Assignee: Ethicon LLC
    Inventors: Michael J. Vendely, Frederick E. Shelton, IV, Jason L. Harris, Howell T. Goldrein, Robert S. Moir, Sofia Maria Consonni, Ismail Akram, Ashley D. Easter, Helen S. Latham
  • Patent number: 10271942
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 30, 2019
    Assignee: Arthrex, Inc.
    Inventors: John Tokish, David Shepard, Brian Dorn
  • Patent number: 10258504
    Abstract: A method of repairing a detached retina includes removing sub-retinal fluid from a location within the eye between the retinal tissue and an underlying support tissue, inserting a biocompatible elastomeric patch having encapsulated ferromagnetic particles into an interior of the eye through an incision of a sclera of the eye, positioning a magnetic source adjacent to an exterior surface of the eye such that the magnetic source is aligned with the detached retinal tissue, and drawing the removable elastomeric patch toward the detached portion of the retina with the magnetic source such that the detached retinal tissue is substantially maintained against underlying support tissue along an inner eye wall by magnetic attraction between the encapsulated magnetic particles of the removable elastomeric patch and the magnetic source.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 16, 2019
    Inventor: Richard Breazeale
  • Patent number: 10232081
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 19, 2019
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Patent number: 10201633
    Abstract: Compositions and methods for glass composites suitable for tissue augmentation, biomedical, and cosmetic applications are provided. The glass microsphere component of the composites are biologically inert, non-reactive and act as a nearly permanent tissue filler. One embodiment provides a tissue augmentation composite containing an effective amount of solid glass microspheres, hollow glass microspheres, porous wall hollow glass microspheres, or combinations thereof with a suitable biocompatible matrix to serve as a bulking agent when injected into a patient. The compositions can be used for soft or hard tissue augmentation as well as delivery of cargos on demand.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: February 12, 2019
    Assignees: Augusta University Research Institute, Inc., Applied Research Center, Inc.
    Inventors: Paul M. Weinberger, William D. Hill, George G. Wicks
  • Patent number: 10188495
    Abstract: A non-setting agent for positioning a surgical mesh prosthesis against a tissue defect during surgical hernia repair enables a surgeon to position the surgical mesh prosthesis at an optimal location against the tissue defect without pre-measuring suture location and pre-suturing. The surgical mesh prosthesis can be repositioned by removing and replacing, or by sliding, the mesh along the tissue defect without traumatizing the tissue. The positioning agent is provided with adhesion and lubricity characteristics providing an adhesion strength required to temporarily maintain the surgical mesh in place, otherwise unsupported, against tissue of a targeted tissue location, and providing a viscosity that permits removal and replacement, or slidable movement, of the surgical mesh along the tissue upon receipt of a non-gravitational external force applied to the surgical mesh so movement of the surgical mesh that is atraumatic to the tissue.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: January 29, 2019
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Roger Labrecque, Stephanie Santos
  • Patent number: 10071120
    Abstract: An osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is provided. The mixture is visible under X ray and remodels more easily than comparable mixtures of demineralized bone matrix and surface demineralized cortical bone chips. The osteoinductive implantable compositions comprises demineralized bone fibers in an amount from about 30 vol % to about 45 vol % and mineralized bone fibers in an amount from about 55 vol % to about 70 vol %. The osteoinductive implantable compositions can be delivered in delivery systems including mesh coverings for administration at surgical sites. A method of treating a bone defect caused by injury, disease, wounds, or surgery utilizing the osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is also provided.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: September 11, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Guobao Wei
  • Patent number: 10058410
    Abstract: The present invention relates to a prosthesis for inguinal hernioplasty made up of a surgical mesh extending from a first end (6) to a second end (7) along a longitudinal direction (A) and comprising a first portion (1) that includes said first end (6), a second portion (2) that includes said second end (7) and a connecting portion (3) arranged between said first portion (1) and said second portion (2), wherein said first portion (1) has a substantially ring shape that is or open or may be opened and is provided with a central hole (4), wherein said second portion (2) has a substantially elongated shape in said longitudinal direction (A), and wherein said connecting portion (3) has a width transverse to said longitudinal direction (A) smaller than the widths of said first portion (1) and said second portion (2) transverse to said longitudinal direction (A).
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 28, 2018
    Inventor: Angelo Guttadauro
  • Patent number: 10039627
    Abstract: In an embodiment, the invention discloses an implant that includes a first elongate member and a second elongate member formed monolithically with the first elongate member out of a single material and planar strip of material. The first elongate member includes a distal end portion and a proximal end portion. The second elongate member includes a first portion and a second portion. Further, each of the first portion of the second elongate member and the second portion of the second elongate member includes a proximal end portion and a distal end portion. The first portion and the second portion extend from the first elongate member. The distal end portion of the first elongate member is configured to be attached to or proximate a sacrum.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: August 7, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Michael S. H. Chu
  • Patent number: 10022473
    Abstract: A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: July 17, 2018
    Assignee: LifeCell Corporation
    Inventor: Wendell Sun
  • Patent number: 9994975
    Abstract: Electrospinning apparatus and method for producing multi-dimensional structures such as one-dimensional continuous yarns, two-dimensional mats and three-dimensional cotton-like fluffy scaffolds is disclosed. Further, electrospinning apparatus and method with single collector geometry for producing multi-dimensional structures and core-sheath yarns are disclosed.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 12, 2018
    Inventors: Deepthy Menon, John Joseph, Shantikumar Nair
  • Patent number: 9993326
    Abstract: A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: June 12, 2018
    Assignee: Histogenics Corporation
    Inventors: Sonya Shortkroff, Laurence J. B. Tarrant, Eric J. Roos, Robert Lane Smith, Hans P. I. Claesson
  • Patent number: 9962251
    Abstract: A medical device assembly includes an implant having a support portion, and an arm portion and a dilator. The medical device assembly further includes a first suture having a first portion coupled to the arm portion of the implant, and a second portion coupled to the dilator. In addition, the assembly includes a second suture having a first portion coupled to the arm portion of the implant, and a second portion coupled to the dilator.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: May 8, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: James M. Goddard, Jamie Li
  • Patent number: 9951221
    Abstract: A thermally degradable polymeric fiber comprising a polymeric fiber matrix including a poly(hydroxyalkanoate) and a metal in the form of a compound selected from the group consisting of an alkaline earth metal oxide, a tin salt of a mono- or di-carboxylic acid, and scandium triflate (Sc(0Tf)3), where the concentration of the metal in the fiber matrix is at least 0.1 wt %.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: April 24, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Aaron P. Esser-Kahn, Hefei Dong, Piyush R. Thakre, Jason F. Patrick, Nancy R. Sottos, Jeffrey S. Moore, Scott R. White
  • Patent number: 9925030
    Abstract: Stitching patterns overlap to produce a corner-locked stitch pattern. The corner-locked stitch pattern includes one or more thread interlace points, and one or more overlays of threads from overlapping patterns. A network of corner-lock stitch patterns produces a mesh, which may be embroidered into a substrate, such as a medical textile or biotextile. Corner-lock stitch patterns resist puncture-induced and tension-induced deformation of mesh pores between corner-locked stitch patterns, and may be used to modulate compliance and enhance strength properties of a substrate into which they are sewn.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: March 27, 2018
    Assignee: TELA Bio, Inc.
    Inventors: Skott Greenhalgh, John-Paul Romano
  • Patent number: 9901601
    Abstract: Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 27, 2018
    Assignee: ADEKA CORPORATION
    Inventors: Akio Kishida, Seiichi Funamoto, Yoshihide Hashimoto, Jun Negishi, Souichiro Kuwa, Takao Ema, Kuniharu Kobayashi
  • Patent number: 9901659
    Abstract: A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which comprises a mammalian blood product such as serum, plasma or platelet rich plasma. The matrix is useful as a cell-growth matrix and for repair of a tissue in a mammal, for instance by implantation in a mammal at a site in need of repair, such as in an abdominal wall.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: February 27, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yi Hong, Nicholas J. Amoroso, Kazuro Lee Fujimoto, Ryotaro Hashizume, William R. Wagner
  • Patent number: 9877820
    Abstract: The invention relates to a prosthesis (1) for the repair of an inguinal hernia comprising: a textile (2) of elongate shape, a resilient frame (3) connected to said textile, characterized in that said frame comprises a convex cranial segment (3c), a caudal segment (3d), a lateral corner segment (3b) joining together the convex cranial segment and the caudal segment, and a folding segment (5) joining a medial end of said convex cranial segment to a point located on the caudal segment while leaving the region of the medial end of the textile free of any frame, said frame being able to adopt an unstressed configuration, in which said textile is deployed, and a stressed configuration, in which said convex cranial segment, said caudal segment and said folding segment are substantially collected together and aligned on one folding direction, said textile forming thereby at least one fold along said folding direction.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 30, 2018
    Assignee: Sofradim Production
    Inventors: Pierre Bailly, Mylene Desorme, Genevieve Doucet
  • Patent number: 9820838
    Abstract: A novel single plane tissue repair device such as a patch is disclosed. The device has a base member with an opening therethrough, and a closure member associated with the opening. The mesh has a biaborbable polymeric adhesion barrier attached to the bottom side of the base member about its periphery to form a pocket that is accessible through the opening. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 21, 2017
    Assignee: Ethicon, Inc.
    Inventors: Xiaodong Liu, Michael Cardinale
  • Patent number: 9820839
    Abstract: A novel single plane tissue repair patch is disclosed. The patch has a base member with an opening therethrough, and a closure member associated with the opening. Mounted to the periphery of the bottom side of the base member is a locating structure. The mesh may be used in open surgical procedures for hernia repairs and other repairs of body wall defects.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 21, 2017
    Assignee: Ethicon, Inc.
    Inventors: Gabriel R. Jacinto, Michael Cardinale, Lynn Louese McRoy, Harry Martin Chomiak
  • Patent number: 9821500
    Abstract: In an apparatus for manufacturing a hybrid scaffold, a first strand having bin compatible polymer and a second strand having a mixture of bio compatible material and cells alternate with each other. Thus, mechanical strength of the hybrid scaffold is improved, and the cells uniformly grow among entire region of the scaffold. Furthermore, diameters of the first and second strands and interval between the first and second strands are precisely controlled. Thus, the hybrid scaffold is precisely manufactured according to a scaffold design.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 21, 2017
    Assignee: Korea Institute of Machinery & Materials
    Inventors: Junhee Lee, Sua Park, Wan-Doo Kim
  • Patent number: 9820843
    Abstract: Materials for soft tissue repair, and in particular, material for hernia repair. These materials may be configured as an implant, such as a graft, that may be implanted into a patient in need thereof, such as a patient having a hernia or undergoing a hernia repair surgical procedure. These grafts may include a first layer comprising a substrate (e.g., mesh) and a second layer comprising a sheet of anti-adhesive material. The layers may be attached with a plurality of relatively small attachment sites that are separated by regions in which the two layers are not attached, to provide a highly compliant graft.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 21, 2017
    Assignee: TELA Bio, Inc.
    Inventors: Skott Greenhalgh, John-Paul Romano, Travis Speicher
  • Patent number: 9789136
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: October 17, 2017
    Assignees: ABT Holding Company, Regents of the University of Minnesote
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Patent number: 9775699
    Abstract: In an embodiment, the present invention discloses a medical assembly, including a sub-urethral implant, a strap, a dilator, and a suture. The implant includes a first end portion and a second end portion such that the strap is configured to be attached to the first end portion of the implant. The strap is attached to the implant through a weld. The strap is further configured to be coupled to the dilator. The suture can be coupled to the dilator.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: October 3, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Kristina Yim Jenkins
  • Patent number: 9737635
    Abstract: The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: August 22, 2017
    Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CORNELL UNIVERSITY
    Inventors: Bryan Nicklaus Brown, Jonathan Cheetham
  • Patent number: 9688962
    Abstract: The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing extracellular matrix remodeling and neovessel formation in an in vitro culture system and generating vascularized engineered tissue constructs using ultrasound technology.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: June 27, 2017
    Assignee: University of Rochester
    Inventors: Diane Dalecki, Denise Hocking, Kelley Garvin
  • Patent number: 9681953
    Abstract: The present invention relates to a complex support body for regenerating bone-cartilage, a method for manufacturing thereof, and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient, and more particularly, to a complex support body for regenerating bone-cartilage, which comprises a bone regeneration layer consisting of a biodegradable polymer and a biocompatible ceramic, and a cartilage regeneration layer, which is coupled to the bone regeneration layer and in which cells that can be differentiated into cartilages cells are fixed; a method for manufacturing thereof; and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: June 20, 2017
    Assignee: INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jung Woog Shin, Ji Won Shin, So Hee Park
  • Patent number: 9636160
    Abstract: An implant including a screw body composed of pure magnesium or a magnesium alloy and having a male thread, and the implant further including an anodized membrane covering an outer surface of the screw body. The male thread has a clearance flank and a pressure flank. The clearance flank faces forward in a traveling direction and the pressure flank faces rearward in the traveling direction during a screwing process of the screw body. The biodegradation period of the anodized membrane on the clearance flank is shorter than the biodegradation period of the anodized membrane on the pressure flank.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 2, 2017
    Assignee: OLYMPUS CORPORATION
    Inventors: Jun Honda, Takamitsu Sakamoto
  • Patent number: 9592108
    Abstract: The present disclosure includes systems and a method for in situ application of a surgical patch during minimally invasive surgery. The method includes the steps of inserting a surgical patch into a bag; transferring a polymeric bag containing a hemostatic patch into a body cavity; removing the surgical patch from the polymeric bag while the polymeric bag is within the body cavity; and applying the surgical patch to a tissue within the body cavity.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 14, 2017
    Assignee: Covidien LP
    Inventors: Kevin Lavigne, Steven Bennett, Nathaniel Mast
  • Patent number: 9549808
    Abstract: A method for constructing a vascular connector configured to bypass an occluded vessel which comprises a primary graft stem and a venous outflow stem. In general, the primary graft stem accepts a blood flow from an occluded vessel to bypass the occlusion. The venous outflow stem may extend from a wall of the primary graft stem and divert a portion of the blood flow to a native vein or other vessel of the vascular system. This configuration is beneficial in ensuring adequate blood flow at the vascular connector to inhibit the formation of clots and to extend the patency of the vascular connector.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: January 24, 2017
    Assignee: Stanley Batiste
    Inventors: Stanley Batiste, Steven Achstein
  • Patent number: 9545302
    Abstract: An apparatus and method for the production of substitute skin that advantageously reduces the amount of donor dermal cells needed from non-wound areas of a patient having a wound to be auto-grafted is reduced by using all of the harvested skin cells. A 3D printer is used to construct a wound graft product from the harvested skin cells without wasting any of the harvested skin cells. In a case of an irregularly shaped wound, wastage of harvested skin associated with trimming is avoided.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: January 17, 2017
    Assignee: DermaGenesis LLC
    Inventors: David Tumey, Sandra Berriman
  • Patent number: 9532888
    Abstract: Various embodiments of stents with radiopaque markers disposed within depots in the stent, are described herein.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: January 3, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Stephen R. Dugan, Anthony J. Abbate
  • Patent number: 9504557
    Abstract: There is disclosed an apparatus and method of manufacture relating to a pre-sutured, high-strength allograft tendon construct. One embodiment of the allograft tendon construct includes first and second tendon lengths that are positioned longitudinally in parallel to one another. A whip stitched pattern secures the first and second tendon lengths at a free end, forming a stitched end portion that abuts an unstitched middle portion. The whip stitched pattern includes a plurality of sutures that originate adjacent to the free end and progress or advance inward toward the unstitched middle portion. A multiple knot bundle is applied immediately prior to a final suture, such that the final suture loops about the multiple knot bundle and locks the multiple knot bundle in place beneath the final suture. Other embodiments are also disclosed.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: November 29, 2016
    Assignee: Allosource
    Inventors: Adrian Samaniego, Matt Southard, Wendy Desiree Franklin, Jessica Hodgkiss, Bilal Karaze
  • Patent number: 9452239
    Abstract: Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: September 27, 2016
    Assignees: William Marsh Rice University, University of Pennsylvania
    Inventors: Jennifer L. West, Christopher S. Chen, Jordan S. Miller, Michael T. Yang
  • Patent number: 9382386
    Abstract: The present invention relates to a lactide copolymer having excellent general physical properties such as mechanical physical properties, processability, and the like, and having excellent flexibility to be effectively usable as a packaging material, and the like, a preparing method thereof, and a resin composition including the same, wherein the lactide copolymer includes: two or more block copolymer repeating units in which hard segments of polylactide repeating units are bound to both ends of soft segments of polyether polyol repeating units, the block copolymer repeating units are linked with each other via a urethane linking group induced from a polyvalent isocyanate compound having more than 2 to less than 3 equivalents of an isocyanate group per a molecule, and the polyether polyol repeating unit has a number average molecular weight of 1000 to 10000.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: July 5, 2016
    Assignee: LG Chem, Ltd
    Inventors: Jung Min Sohn, Seung Young Park, Kyung Seog Youk, Seung Ho Choi
  • Patent number: 9345808
    Abstract: The invention relates to a structure having fibers which are adhesively bonded to one another in locations and have a permeability for air of between 0.5 ml/min*cm2 and 1.5 ml/min*cm2, wherein said structure has an at least one-sided coating which reduces the permeability of the structure to below 0.2 ml/min*cm2.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: May 24, 2016
    Assignee: Occlutech Holding AG
    Inventors: Christoph Classen, Swen Franzen, Harrie Van Baars, Wolfgang Witt, Andreas Henseler, Frank Willems
  • Patent number: 9333277
    Abstract: An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: May 10, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9211266
    Abstract: An object of the present invention is to provide a cell construct for cell transplantation capable of having a thickness suitable for cell transplantation, preventing the necrosis of transplanted cells, and forming blood vessels in the transplantation site after transplantation. The present invention provides a cell construct for cell transplantation which comprises polymer blocks having biocompatibility and cells of at least one type, wherein the plural polymer blocks are arranged in spaces between the plural cells.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: December 15, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Reiko Iwazawa, Kentaro Nakamura
  • Patent number: 9205047
    Abstract: The incorporation of polymeric excipients into an injectable hydrogel matrix, for example, methyl cellulose in the case of a hydrogel matrix comprising hyaluronan and methylcellulose (HAMC) has been found to increase the solubility of sparingly soluble hydrophobic drugs and tune their rate of release. The hydrogel matrix may also include other sparingly soluble hydrophobic food or cosmetic agents.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: December 8, 2015
    Assignee: The Governing Council of the University of Toronto
    Inventors: Molly S. Shoichet, Yakov Lapitsky, Yuanfei Wang
  • Patent number: 9198750
    Abstract: A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: December 1, 2015
    Assignee: Rotation Medical, Inc.
    Inventors: Craig Van Kampen, Nathaniel Zenz-Olson, Thomas A. Westling, Charles L. Euteneuer
  • Patent number: 9149562
    Abstract: A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: October 6, 2015
    Assignee: Histogenics Corporation
    Inventors: Sonya Shortkroff, Laurence J. B. Tarrant, Eric J. Roos, Robert Lane Smith, Hans P. I. Claesson
  • Patent number: 9101458
    Abstract: Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include acellular arterial tissue matrices that facilitate regrowth of the damaged tissue.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: August 11, 2015
    Assignee: LifeCell Corporation
    Inventors: Wenquan Sun, Gary Monteiro
  • Patent number: 9072810
    Abstract: The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: July 7, 2015
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Wing Yuk Ip, Chi Keung Yuen