Tissue Patents (Class 623/23.72)
  • Patent number: 11564790
    Abstract: A method includes forming a scaffold and seeding the scaffold with live cells; growing the cells in the scaffold; and 3D printing the cells into a living subject, where the cells continue to live in the living subject.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: January 31, 2023
    Inventor: Mariela Aguilar
  • Patent number: 11554032
    Abstract: Devices and methods for protecting the neurovascular structures about the vertebral column are provided. One embodiment of the invention comprises a neuroprotective stent or device adapted for placement in an intervertebral foramen of a vertebral column and configured to resist compression or impingement from surrounding structures or forces. The stent or device may further comprise a flange or hinge region to facilitate attachment of the device to the vertebrae or to facilitate insertion of the device in the foramen, respectively.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: January 17, 2023
    Assignee: Spinal Elements, Inc.
    Inventor: Jason Blain
  • Patent number: 11540507
    Abstract: The present invention provides a solution for cryopreservation of animal cells or animal tissues which substantially includes a cryoprotectant that contains 0.5 w/v % to 6.0 w/v % of dextran or derivatives thereof or salts thereof and contains dimethyl sulfoxide, and includes a physiological aqueous solution; a cryopreserved product of animal cells or animal tissues which includes animal cells or animal tissues, and includes the above-described solution for cryopreservation of animal cells or animal tissues; and a cryopreservation method of animal cells or animal tissues, which is a method using the above-described solution for cryopreservation of animal cells or animal tissues.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: January 3, 2023
    Assignee: The University of Tokyo
    Inventors: Tokiko Nagamura, Yuka Mori, Takahisa Shimadzu
  • Patent number: 11504003
    Abstract: Anchors and anchoring methods suitable for use with implantable assemblies that include an implantable device, including but not limited to implantable sensing devices and implantable wireless sensing devices adapted to monitor physiological parameters within living bodies. Such an implantable device has a housing containing a transducer, electrical circuitry, and an antenna. The transducer is located at a first end of the housing opposite a second end of the housing. At least the transducer is located within a housing portion of the housing in which the antenna is not located. The implantable assembly further includes an anchor is adapted for securing the implantable device within a living body.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: November 22, 2022
    Assignee: UIM Pressure Implant Inc.
    Inventor: Nader Najafi
  • Patent number: 11497830
    Abstract: Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: November 15, 2022
    Assignee: SCRIPPS HEALTH
    Inventors: Darryl D. D'Lima, Shawn Grogan, Clifford W. Colwell, Jr., Jihye Baek
  • Patent number: 11471258
    Abstract: The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: October 18, 2022
    Assignee: NOVUS SCIENTIFIC AB
    Inventors: Torbjörn Mathisen, Anna Wistrand
  • Patent number: 11473054
    Abstract: Provided is a method for producing a three-dimensional tissue having a vascular system structure, said method comprising: (a) a step for forming a vascular system structure template using a gel; (b) a step for forming a three-dimensional tissue in the vicinity of the template; (c) a step for dissolving the template using a cationic solution; and (d) a step for seeding vascular endothelial cells and/or lymphatic vessel endothelial cells in a void remaining after the dissolution of the template. Also provided is a method for producing a three-dimensional tissue having a vascular system structure, said method comprising: (i) a step for forming a vascular system structure template using a gel; (ii) a step for seeding vascular endothelial cells and/or lymphatic vessel endothelial cells on the template; (iii) a step for forming a three-dimensional tissue in the vicinity of the cells seeded above; and (iv) a step for dissolving the template using a cationic solution.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: October 18, 2022
    Assignee: OSAKA UNIVERSITY
    Inventor: Michiya Matsusaki
  • Patent number: 11453181
    Abstract: A preform figuring method includes mounting and stacking sheet-shape fibrous preparations that have been or are yet to be impregnated with a thermosetting resin on a figuring die that has first and second figuring surfaces at least either one of which is a curved surface and making a preform for a composite material which has a curved surface that corresponds to the curved surface of the figuring die as a stack of the fibrous preparations which has layers by bending the fibrous preparations mounted on the first figuring surface onto the second figuring surface. At least a fraction of the layers that constitute the stack are formed by mounting sheet-shape fibrous preparations on the first figuring surface or the fibrous preparation adjacent in a stacking direction so that the fibrous preparations partly overlap and bending portions of the fibrous preparations mounted so as to overlap onto the second figuring surface.
    Type: Grant
    Filed: November 3, 2018
    Date of Patent: September 27, 2022
    Assignee: SUBARU CORPORATION
    Inventors: Saori Kato, Yuta Inoue, Yohei Hamamoto, Naoyuki Sekine, Yuji Odaka
  • Patent number: 11439431
    Abstract: An apparatus includes a handle assembly, a shaft assembly, an end effector, and an auto-tensioning feature. The handle assembly includes a body and a plunger. The shaft assembly includes an external sheath that is fixed to the handle body and an interior shaft that is coupled to the plunger. The interior shaft is slidable relative to the external sheath. The end effector is configured to encompass a bodily lumen and includes a flexible member extending distally from the interior shaft. A first coupling element is fixed to the distal tip of the flexible member. A second coupling element is fixed to the external sheath. The first and second coupling elements are magnetically attracted to each other and are biased toward each other such that the flexible member defines an adjustable loop. The auto-tensioning feature is configured to bias the plunger portion proximally relative to the handle body.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: September 13, 2022
    Assignee: Cilag GmbH International
    Inventors: Lauren E. Flakne, Michael D. Auld, Brett E. Swensgard, Kyle P. Taylor, Celeste L. Huster, Jerome K. Grudem, Jr.
  • Patent number: 11426156
    Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: August 30, 2022
    Assignee: New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery
    Inventor: Struan H. Coleman
  • Patent number: 11400183
    Abstract: A bioprinter comprises one or more dispensing units. Each dispensing unit may include (i) a syringe including a hollow body and a plunger dimensioned to translate in the body wherein the body has an exit orifice; (ii) an actuator in contact with a proximal end of the plunger; (iii) a controller for moving the actuator; and (iv) a nozzle having a wall defining a fluid path extending from an inlet of the nozzle to an outlet of the nozzle. The inlet of the nozzle is in fluid communication with the exit orifice of the syringe body. The nozzle includes a fluid passageway in fluid communication with a source of fluid and the fluid path. The bioprinter can be used in a method of preparing microtissue comprising dispensing a bioink from one or more dispensing units of the bioprinter on a plate. The microtissue may comprise cartilage cells or tumor cells or liver cells.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: August 2, 2022
    Assignee: The General Hospital Corporation
    Inventors: Yonggang Pang, Brian Grottkau
  • Patent number: 11375988
    Abstract: The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. In some embodiments, the occluder is formed from filaments that are joined together to define a substantially cylindrical form with openings defining struts. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is engaged so that the occluder closes the aperture.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: July 5, 2022
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: David J. Callaghan
  • Patent number: 11370929
    Abstract: Provided is a bioink set for printing a construct that is able to carry cells, including a bioink which contains a biodegradable polyurethane and a biopolymer, and a divalent metal ion solution. The biopolymer is gelatin, agar, alginate salts, hyaluronic acid and salts thereof, chitosan, and any combination thereof. Also provided are a method of preparing a construct for carrying cells by three-dimensional printing with the bioink set, and a method of three-dimensional printing of cells by using an ink composition.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 28, 2022
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Shan-hui Hsu, Cheng-Tien Hsieh
  • Patent number: 11369465
    Abstract: Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: June 28, 2022
    Assignee: SCRIPPS HEALTH
    Inventors: Darryl D. D'Lima, Clifford Colwell
  • Patent number: 11357660
    Abstract: A medical device for repositioning tissue within an animal has a main body with a first end portion, a second end portion, and a middle portion. The first end portion defines a series of passageways and the second end portion defines a bulbous shape, a slot, and a tab portion. Methods of treating obstructive sleep apnea are also described.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: June 14, 2022
    Assignees: Cook Medical Technologies, LLC, Cook Biotech Incorporated
    Inventors: Peter O'Connor, Wade Colburn, Chelsea McKiernan, Andrew P. Isch, Alexander Brethauer
  • Patent number: 11332714
    Abstract: The present disclosure provides a cell system comprising eukaryotic cells in a hydrogel comprising nanofibrillar cellulose in cell storage medium at a temperature in the range of 0-25° C. The present disclosure also provides a method for storing eukaryotic cells, the method comprising providing eukaryotic cells, providing nanofibrillar cellulose, combining the cells and the nanofibrillar cellulose to form the cell system, and storing the cell system at a temperature in the range of 0-25° C.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: May 17, 2022
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Markus Nuopponen, Jane Spencer-Fry, Karen Coopman
  • Patent number: 11298441
    Abstract: The present invention relates to the unexpected discovery of 3D printed biomimetics of growth plate cartilage and methods using the same for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of bony bars at the site of growth plate injury, thereby preventing growth arrest and/or deformity.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 12, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Karin A. Payne, Stephanie Bryant, Virginia Ferguson, Nancy Hadley-Miller, Robert McLeod
  • Patent number: 11266763
    Abstract: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hallow organs present in the respiratory system such as bronchus tissue.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: March 8, 2022
    Assignee: Biostage, Inc.
    Inventors: William Fodor, Linghui Meng, Sherif Soliman, Shunfu Hu
  • Patent number: 11253635
    Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: February 22, 2022
    Assignee: Washington University
    Inventor: Matthew R. MacEwan
  • Patent number: 11224546
    Abstract: A hollow fiber that extending along at least a portion of the fiber along a longitudinal axis thereof and is defined by an interior wall is provided. Through selective control over the manner in which it is formed, the present inventors have discovered that the hollow fiber can exhibit a unique combination of a high void fraction and small fiber size that makes it particularly suitable for use in certain applications, such as in nonwoven webs for absorbent articles.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: January 18, 2022
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Eric E. Lennon, John H. Conrad, Douglas J. Hulslander, David W. Hall
  • Patent number: 11214768
    Abstract: Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: January 4, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jennifer A. Lewis, Mark A. Skylar-Scott, David B. Kolesky, Kimberly A. Homan, Alex H. M. Ng, George M. Church
  • Patent number: 11207168
    Abstract: The present disclosure relates to skirted hernia repair devices which includes at least a first mesh layer having a first side, a second side, and an outer peripheral edge, a skirt mesh layer positioned on the first side of the first mesh layer, the skirt mesh layer having an inner peripheral edge defining an opening in the skirt mesh layer, and, at least one reinforcement member that prevents the skirt mesh layer from inverting.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: December 28, 2021
    Assignee: Covidien LP
    Inventors: Mark Russo, Raylene Worthington
  • Patent number: 11207530
    Abstract: An implantable medical device includes an improved tether catch formed by a relatively rigid structure that has a hook surface extending between first and second ends thereof. The second end of the structure is spaced apart from another portion of the device by a gap of a size no greater than a thickness of a tether, for which the tether catch is formed to engage, when the tether is looped within a delivery catheter. The device may be loaded into the catheter by: positioning the looped portion of the tether in close proximity to the gap of the tether catch; creating tension in the positioned tether to bring the looped portion into a perimeter of the hooked surface; and then pulling the tether so that the looped portion thereof bears against the hooked surface, thereby bringing the device into engagement with a distal-most end of the delivery catheter.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 28, 2021
    Assignee: Medtronic, Inc.
    Inventor: Rónán Wood
  • Patent number: 11123293
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 21, 2021
    Assignee: Moebius Medical Ltd.
    Inventors: Yechezkel Barenholz, Yaniv Dolev, Keren Turjeman, Gadi Sarfati, Maty Ayal-Hershkovitz
  • Patent number: 11058529
    Abstract: A composite soft tissue repair material stable in repair area, includes a middle mechanical reinforcement layer containing crosslinked acellular matrix; and upper and lower layers containing non-crosslinked acellular matrix, wherein the upper and lower layers completely encapsulate the middle mechanical reinforcement layer to form a sandwich structure. The present invention combines the advantages of crosslinked acellular matrix and non-crosslinked acellular matrix, including high histocompatibility, no viscera erosion, uniform thickness of the whole material, resistance to infection, long-term mechanical stability of the repair area, et al, which has good application prospects.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: July 13, 2021
    Assignees: Shanghai Zhuoruan Medical Technologies Co., Ltd, Zhuoruan Medical Technologies (Suzhou) Co., Ltd
    Inventor: Jian Zhang
  • Patent number: 11027048
    Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 8, 2021
    Assignee: DECELL TECHNOLOGIES INC.
    Inventor: Paul Frank Gratzer
  • Patent number: 11028362
    Abstract: Provided herein is an isolated decelluarized amniotic membrane (DCM) and methods for using same therapeutically in vivo and in vitro. In one aspect, the isolated DCM is further processed, freezing, freeze drying, lyophilization micronized into powder or treatment with pepsin to create a hydrogel.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 8, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Volodymyr Ryzhuk, Aijun Wang, Diana Farmer, Benjamin Keller
  • Patent number: 11008425
    Abstract: A method for producing a metal nanoparticle-loaded biopolymer microgel involving the reduction of metal ions in a metal ion-loaded biopolymer microgel. The method yields a metal nanoparticle-loaded biopolymer microgel. Also disclosed is a method of catalytically reducing an organic pollutant in water using the metal nanoparticle-loaded biopolymer microgel and a reducing agent.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: May 18, 2021
    Assignee: King Abdulaziz University
    Inventors: Tahseen Kamal, Abdullah M. Asiri, Sher Bahadar Khan
  • Patent number: 10975220
    Abstract: Articles are provided, including a porous elastomeric material having a first major surface and an elastomeric material integrated into the first major surface of the porous elastomeric material. The elastomeric material coating the first major surface, a first portion of the elastomeric material being disposed within a plurality of pores defined by the first major surface of the porous elastomeric material and extending into the plurality of pores to a depth of at least 300 micrometers (?m), wherein the first portion of the elastomeric material provides fluid communication through the porous elastomeric material via holes formed in the elastomeric material extending into the thickness of the porous elastomeric material through the voids of the pores of the elastomeric material. A method of making an article is also provided.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: April 13, 2021
    Assignee: 3M Innovative Properties Company
    Inventors: Kurt J. Halverson, Cary A. Kipke
  • Patent number: 10973953
    Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 13, 2021
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
  • Patent number: 10941380
    Abstract: Embodiments of the presently disclosed subject matter provide biomimetic cell culture substrates comprising highly tunable patterned polymer nanofiber matrices capable of modulating expression of critical self-renewal factors and markers of cell-cell interaction to maintain stemness of human mesenchymal stem cells in vitro. Embodiments of the presently-disclosed subject matter also provide scalable, highly repeatable methods of making biomimetic cell culture substrates by hot pressing thermoplastic polymer films into femtosecond laser-ablated nanopore molds to form patterned polymer nanofiber matrices on flat thermoplastic substrates.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 9, 2021
    Assignee: Ultra Small Fibers, LLC
    Inventors: William Hudson Hofmeister, Lucas Hofmeister, Alexander Yuryevich Terekhov, Jose Lino Vasconcelos da Costa
  • Patent number: 10933163
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 2, 2021
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Patent number: 10918765
    Abstract: The present invention provides systems and methods for the decellularization and recellularization of tissue segments. In certain instances the invention comprises coating or sealing decellularized tissue segments with a cross-linked alginate hydrogel. The present invention also provides a decellularization kit, which may be used to generate decellularized tissue segments for high throughput studies. Also included are compositions and methods of tissue sealants comprising methacrylated alginate.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: February 16, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Darcy Wagner, Daniel J. Weiss, Nicholas Bonenfant, Rachael Oldinski, Spencer Fenn
  • Patent number: 10905740
    Abstract: An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a fused deposition modeling process, a selective laser sintering process, a selective heat sintering process, a digital light processing process, or a stereolithography process. The antibiotic-eluting article may be temporary or permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, and/or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: February 2, 2021
    Assignee: ORTHOPAEDIC INNOVATION CENTRE INC.
    Inventors: Martin Petrak, Luke M. B. Rodgers
  • Patent number: 10905798
    Abstract: A biological construct for the repair and replacement of damaged connective tissue is provided. Methods of repairing or otherwise replacing connective tissue are also provided.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 2, 2021
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10900017
    Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: January 26, 2021
    Assignee: HISTOGENICS CORPORATION
    Inventors: Robert Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans P. I. Claesson
  • Patent number: 10857263
    Abstract: A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: December 8, 2020
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 10835635
    Abstract: A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of the natural polymer mixture is described. Use of an activating agent and a combination of the natural polymers is unique. The natural polymer tissue adhesive may be useful as a post-operative application for tonsillectomy or adenoidectomy surgery, as an internal tissue adhesive for surgery or wound repair or for application to a burn or skin donor site. For internal use, an optional treatment to improve resistance of the activated adhesive to body fluids is also described. The adhesive described not only functions as an adhesive but would also serve as a protective barrier when applied to surgery or skin sites. In addition, the natural polymers would promote healing due to the inherent properties of the polymers selected.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 17, 2020
    Assignee: HCS Innovation, LLC
    Inventors: Ronnie Michael Hanes, Adele Lamping Hanes
  • Patent number: 10835235
    Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 17, 2020
    Assignee: New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
    Inventor: Struan H. Coleman
  • Patent number: 10828391
    Abstract: Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: November 10, 2020
    Assignee: LifeCell Corporation
    Inventors: Wenquan Sun, Melissa Richter Bowley, Raghav Goel
  • Patent number: 10792145
    Abstract: In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (AHM) patch. In some embodiments, the method includes obtaining and/or isolating cells from a subject. In some embodiments, the cells are primary cardiac cells. In some embodiments, the method further includes forming a scaffold. In some embodiments, the method includes seeding the cells in the fibrin gel scaffold. In some embodiments, the method includes culturing the cells seeded in the fibrin gel scaffold under conditions appropriate for the formation of an artificial heart muscle (AHM) patch.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 6, 2020
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventor: Ravi K. Birla
  • Patent number: 10765506
    Abstract: A laminate useful as a component of a medical implant, for example, useful as a component of an inflatable tissue expander. The laminate includes a base layer, an intermediate layer, and a top layer. When used as a component of a tissue expander, the laminate enables an internal chamber pressure of about 2.5 psi with an expander exterior compressive force of about 40 lbs.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: September 8, 2020
    Assignee: Allergan, Inc.
    Inventors: Kaustubh S. Chitre, Nicholas Manesis, Nikhil S. Trilokekar, Dustin Leslie, David J. Schuessler
  • Patent number: 10765507
    Abstract: A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: September 8, 2020
    Assignee: Tepha, Inc.
    Inventors: Arikha Moses, Emily Stires, Anthony Natale
  • Patent number: 10758644
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron
  • Patent number: 10729508
    Abstract: A tissue expansion device with a plurality of lobes made from non-compliant material, each lobe defining a chamber therein. Each chamber is fluidly isolated from every other chamber in the plurality of lobes. Each chamber has an inflation element with a valve to release a pressurized fluid to inflate the lobe to expand a cavity, and a deflation element with a valve to deflate the lobe by compressing the fluid.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 4, 2020
    Assignee: Medtronic Advanced Energy LLC
    Inventors: Nathan Zamarripa, Mark Guirguis, Nicholas Valley
  • Patent number: 10722336
    Abstract: The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: July 28, 2020
    Assignee: NOVUS SCIENTIFIC AB
    Inventors: Torbjörn Mathisen, Anna Wistrand
  • Patent number: 10709538
    Abstract: The present invention relates to a prosthesis (200) comprising: one mesh (1) delimited by a peripheral exterior edge (1a), a frame (2) fastened to said mesh and adopting the shape of said peripheral exterior edge of the mesh, said frame being set back from said peripheral exterior edge and being provided with two hinge points (3a, 3b), the line passing through said two hinge points also passing through the centre (1b) of the mesh and thus forming a line M for folding the mesh in two, characterized in that said prosthesis further comprises at least two anchor pieces (5) made of suturable material and located on a single face of the mesh (1) on either side of said folding line, each piece having a fixed part (5a) linked to said mesh and a free part (5b), said free part being linked to at least one thread-shaped element (7).
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 14, 2020
    Assignee: SOFRADIM PRODUCTION
    Inventors: Pierre Bailly, Gaetan Romuald
  • Patent number: 10695463
    Abstract: Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 30, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Rachel McGuire, Ryan Borem, Jeremy Mercuri
  • Patent number: 10682145
    Abstract: Various aspects of the disclosure pertain to blood vessel occlusion devices having a central longitudinal axis and comprising: (a) a hub, (b) a self-expanding support frame comprising a plurality of wire segments forming a plurality of cells, and (c) a covering material covering cells within the transition portion. The support frame may be self-expandable from a constrained shape to an unconstrained shape that comprises (ii) a substantially cylindrical portion having a diameter and an axis that is coincident with the central longitudinal axis, the substantially cylindrical portion comprising a first ring of the cells extending in a 360° rotation around the central longitudinal axis and (ii) a transition portion disposed between the substantially cylindrical portion and the hub. Other aspects for the disclosure pertain to assemblies, kits and methods that employ such devices.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: June 16, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph Michael Connolly
  • Patent number: 10590388
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 17, 2020
    Assignees: UBE INDUSTRIES, LTD., KURUME UNIVERSITY
    Inventors: Keisuke Ohta, Shingo Hirashima, Masahiko Hagihara, Motohisa Shimizu