Tissue Patents (Class 623/23.72)
  • Patent number: 11224546
    Abstract: A hollow fiber that extending along at least a portion of the fiber along a longitudinal axis thereof and is defined by an interior wall is provided. Through selective control over the manner in which it is formed, the present inventors have discovered that the hollow fiber can exhibit a unique combination of a high void fraction and small fiber size that makes it particularly suitable for use in certain applications, such as in nonwoven webs for absorbent articles.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: January 18, 2022
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Eric E. Lennon, John H. Conrad, Douglas J. Hulslander, David W. Hall
  • Patent number: 11214768
    Abstract: Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: January 4, 2022
    Inventors: Jennifer A. Lewis, Mark A. Skylar-Scott, David B. Kolesky, Kimberly A. Homan, Alex H. M. Ng, George M. Church
  • Patent number: 11207530
    Abstract: An implantable medical device includes an improved tether catch formed by a relatively rigid structure that has a hook surface extending between first and second ends thereof. The second end of the structure is spaced apart from another portion of the device by a gap of a size no greater than a thickness of a tether, for which the tether catch is formed to engage, when the tether is looped within a delivery catheter. The device may be loaded into the catheter by: positioning the looped portion of the tether in close proximity to the gap of the tether catch; creating tension in the positioned tether to bring the looped portion into a perimeter of the hooked surface; and then pulling the tether so that the looped portion thereof bears against the hooked surface, thereby bringing the device into engagement with a distal-most end of the delivery catheter.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 28, 2021
    Assignee: Medtronic, Inc.
    Inventor: Rónán Wood
  • Patent number: 11207168
    Abstract: The present disclosure relates to skirted hernia repair devices which includes at least a first mesh layer having a first side, a second side, and an outer peripheral edge, a skirt mesh layer positioned on the first side of the first mesh layer, the skirt mesh layer having an inner peripheral edge defining an opening in the skirt mesh layer, and, at least one reinforcement member that prevents the skirt mesh layer from inverting.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: December 28, 2021
    Assignee: Covidien LP
    Inventors: Mark Russo, Raylene Worthington
  • Patent number: 11123293
    Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 21, 2021
    Assignee: Moebius Medical Ltd.
    Inventors: Yechezkel Barenholz, Yaniv Dolev, Keren Turjeman, Gadi Sarfati, Maty Ayal-Hershkovitz
  • Patent number: 11058529
    Abstract: A composite soft tissue repair material stable in repair area, includes a middle mechanical reinforcement layer containing crosslinked acellular matrix; and upper and lower layers containing non-crosslinked acellular matrix, wherein the upper and lower layers completely encapsulate the middle mechanical reinforcement layer to form a sandwich structure. The present invention combines the advantages of crosslinked acellular matrix and non-crosslinked acellular matrix, including high histocompatibility, no viscera erosion, uniform thickness of the whole material, resistance to infection, long-term mechanical stability of the repair area, et al, which has good application prospects.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: July 13, 2021
    Assignees: Shanghai Zhuoruan Medical Technologies Co., Ltd, Zhuoruan Medical Technologies (Suzhou) Co., Ltd
    Inventor: Jian Zhang
  • Patent number: 11027048
    Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 8, 2021
    Inventor: Paul Frank Gratzer
  • Patent number: 11028362
    Abstract: Provided herein is an isolated decelluarized amniotic membrane (DCM) and methods for using same therapeutically in vivo and in vitro. In one aspect, the isolated DCM is further processed, freezing, freeze drying, lyophilization micronized into powder or treatment with pepsin to create a hydrogel.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 8, 2021
    Inventors: Volodymyr Ryzhuk, Aijun Wang, Diana Farmer, Benjamin Keller
  • Patent number: 11008425
    Abstract: A method for producing a metal nanoparticle-loaded biopolymer microgel involving the reduction of metal ions in a metal ion-loaded biopolymer microgel. The method yields a metal nanoparticle-loaded biopolymer microgel. Also disclosed is a method of catalytically reducing an organic pollutant in water using the metal nanoparticle-loaded biopolymer microgel and a reducing agent.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: May 18, 2021
    Assignee: King Abdulaziz University
    Inventors: Tahseen Kamal, Abdullah M. Asiri, Sher Bahadar Khan
  • Patent number: 10975220
    Abstract: Articles are provided, including a porous elastomeric material having a first major surface and an elastomeric material integrated into the first major surface of the porous elastomeric material. The elastomeric material coating the first major surface, a first portion of the elastomeric material being disposed within a plurality of pores defined by the first major surface of the porous elastomeric material and extending into the plurality of pores to a depth of at least 300 micrometers (?m), wherein the first portion of the elastomeric material provides fluid communication through the porous elastomeric material via holes formed in the elastomeric material extending into the thickness of the porous elastomeric material through the voids of the pores of the elastomeric material. A method of making an article is also provided.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: April 13, 2021
    Assignee: 3M Innovative Properties Company
    Inventors: Kurt J. Halverson, Cary A. Kipke
  • Patent number: 10973953
    Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 13, 2021
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
  • Patent number: 10941380
    Abstract: Embodiments of the presently disclosed subject matter provide biomimetic cell culture substrates comprising highly tunable patterned polymer nanofiber matrices capable of modulating expression of critical self-renewal factors and markers of cell-cell interaction to maintain stemness of human mesenchymal stem cells in vitro. Embodiments of the presently-disclosed subject matter also provide scalable, highly repeatable methods of making biomimetic cell culture substrates by hot pressing thermoplastic polymer films into femtosecond laser-ablated nanopore molds to form patterned polymer nanofiber matrices on flat thermoplastic substrates.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 9, 2021
    Assignee: Ultra Small Fibers, LLC
    Inventors: William Hudson Hofmeister, Lucas Hofmeister, Alexander Yuryevich Terekhov, Jose Lino Vasconcelos da Costa
  • Patent number: 10933163
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 2, 2021
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Patent number: 10918765
    Abstract: The present invention provides systems and methods for the decellularization and recellularization of tissue segments. In certain instances the invention comprises coating or sealing decellularized tissue segments with a cross-linked alginate hydrogel. The present invention also provides a decellularization kit, which may be used to generate decellularized tissue segments for high throughput studies. Also included are compositions and methods of tissue sealants comprising methacrylated alginate.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: February 16, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Darcy Wagner, Daniel J. Weiss, Nicholas Bonenfant, Rachael Oldinski, Spencer Fenn
  • Patent number: 10905740
    Abstract: An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a fused deposition modeling process, a selective laser sintering process, a selective heat sintering process, a digital light processing process, or a stereolithography process. The antibiotic-eluting article may be temporary or permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, and/or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: February 2, 2021
    Inventors: Martin Petrak, Luke M. B. Rodgers
  • Patent number: 10905798
    Abstract: A biological construct for the repair and replacement of damaged connective tissue is provided. Methods of repairing or otherwise replacing connective tissue are also provided.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 2, 2021
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10900017
    Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: January 26, 2021
    Inventors: Robert Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans P. I. Claesson
  • Patent number: 10857263
    Abstract: A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: December 8, 2020
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 10835235
    Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 17, 2020
    Assignee: New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
    Inventor: Struan H. Coleman
  • Patent number: 10835635
    Abstract: A tissue adhesive with healing promotion properties formed from a mixture of natural polymers and an activating agent that enhances the adhesive properties of the natural polymer mixture is described. Use of an activating agent and a combination of the natural polymers is unique. The natural polymer tissue adhesive may be useful as a post-operative application for tonsillectomy or adenoidectomy surgery, as an internal tissue adhesive for surgery or wound repair or for application to a burn or skin donor site. For internal use, an optional treatment to improve resistance of the activated adhesive to body fluids is also described. The adhesive described not only functions as an adhesive but would also serve as a protective barrier when applied to surgery or skin sites. In addition, the natural polymers would promote healing due to the inherent properties of the polymers selected.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 17, 2020
    Assignee: HCS Innovation, LLC
    Inventors: Ronnie Michael Hanes, Adele Lamping Hanes
  • Patent number: 10828391
    Abstract: Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: November 10, 2020
    Assignee: LifeCell Corporation
    Inventors: Wenquan Sun, Melissa Richter Bowley, Raghav Goel
  • Patent number: 10792145
    Abstract: In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (AHM) patch. In some embodiments, the method includes obtaining and/or isolating cells from a subject. In some embodiments, the cells are primary cardiac cells. In some embodiments, the method further includes forming a scaffold. In some embodiments, the method includes seeding the cells in the fibrin gel scaffold. In some embodiments, the method includes culturing the cells seeded in the fibrin gel scaffold under conditions appropriate for the formation of an artificial heart muscle (AHM) patch.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 6, 2020
    Inventor: Ravi K. Birla
  • Patent number: 10765507
    Abstract: A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: September 8, 2020
    Assignee: Tepha, Inc.
    Inventors: Arikha Moses, Emily Stires, Anthony Natale
  • Patent number: 10765506
    Abstract: A laminate useful as a component of a medical implant, for example, useful as a component of an inflatable tissue expander. The laminate includes a base layer, an intermediate layer, and a top layer. When used as a component of a tissue expander, the laminate enables an internal chamber pressure of about 2.5 psi with an expander exterior compressive force of about 40 lbs.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: September 8, 2020
    Assignee: Allergan, Inc.
    Inventors: Kaustubh S. Chitre, Nicholas Manesis, Nikhil S. Trilokekar, Dustin Leslie, David J. Schuessler
  • Patent number: 10758644
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2020
    Inventors: Kathleen Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron
  • Patent number: 10729508
    Abstract: A tissue expansion device with a plurality of lobes made from non-compliant material, each lobe defining a chamber therein. Each chamber is fluidly isolated from every other chamber in the plurality of lobes. Each chamber has an inflation element with a valve to release a pressurized fluid to inflate the lobe to expand a cavity, and a deflation element with a valve to deflate the lobe by compressing the fluid.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 4, 2020
    Assignee: Medtronic Advanced Energy LLC
    Inventors: Nathan Zamarripa, Mark Guirguis, Nicholas Valley
  • Patent number: 10722336
    Abstract: The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: July 28, 2020
    Inventors: Torbjörn Mathisen, Anna Wistrand
  • Patent number: 10709538
    Abstract: The present invention relates to a prosthesis (200) comprising: one mesh (1) delimited by a peripheral exterior edge (1a), a frame (2) fastened to said mesh and adopting the shape of said peripheral exterior edge of the mesh, said frame being set back from said peripheral exterior edge and being provided with two hinge points (3a, 3b), the line passing through said two hinge points also passing through the centre (1b) of the mesh and thus forming a line M for folding the mesh in two, characterized in that said prosthesis further comprises at least two anchor pieces (5) made of suturable material and located on a single face of the mesh (1) on either side of said folding line, each piece having a fixed part (5a) linked to said mesh and a free part (5b), said free part being linked to at least one thread-shaped element (7).
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 14, 2020
    Inventors: Pierre Bailly, Gaetan Romuald
  • Patent number: 10695463
    Abstract: Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 30, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Rachel McGuire, Ryan Borem, Jeremy Mercuri
  • Patent number: 10682145
    Abstract: Various aspects of the disclosure pertain to blood vessel occlusion devices having a central longitudinal axis and comprising: (a) a hub, (b) a self-expanding support frame comprising a plurality of wire segments forming a plurality of cells, and (c) a covering material covering cells within the transition portion. The support frame may be self-expandable from a constrained shape to an unconstrained shape that comprises (ii) a substantially cylindrical portion having a diameter and an axis that is coincident with the central longitudinal axis, the substantially cylindrical portion comprising a first ring of the cells extending in a 360° rotation around the central longitudinal axis and (ii) a transition portion disposed between the substantially cylindrical portion and the hub. Other aspects for the disclosure pertain to assemblies, kits and methods that employ such devices.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: June 16, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph Michael Connolly
  • Patent number: 10590388
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 17, 2020
    Inventors: Keisuke Ohta, Shingo Hirashima, Masahiko Hagihara, Motohisa Shimizu
  • Patent number: 10561494
    Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic heart valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. The delivery apparatus in particular embodiments is configured to deploy a prosthetic valve from a delivery sheath in a precise and controlled manner at the target location within the body.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: February 18, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Jun Liu, Asher L. Metchik, Sergio Delgado
  • Patent number: 10532127
    Abstract: Methods to produce perforated collagen coated meshes for use as implants have been developed. The method involves positioning needles through the pores of the mesh, coating the mesh with a collagen solution, freezing the coated mesh, removing the needles from the frozen coated mesh, drying the collagen coated mesh, and optionally cross-linking the coated mesh. The method allows perforated collagen coated meshes to be prepared with variable thickness, and without damage to the surface of the mesh. The perforations of the collagen coated meshes may be designed to prevent the formation of fluid pockets when the coated meshes are implanted, and to permit rapid incorporation into host tissue. The perforated collagen coated meshes may be used for soft tissue repair, regeneration or remodeling including, for example, hernia repair, mastopexy, treatment of urinary incontinence, pelvic floor reconstruction, and ligament and tendon repair.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 14, 2020
    Assignee: Tepha, Inc.
    Inventors: Skander Limem, Bhavin Shah, Said Rizk
  • Patent number: 10512711
    Abstract: The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: December 24, 2019
    Inventor: Robert G Matheny
  • Patent number: 10507095
    Abstract: A device for the reconstruction of the rotator cuff including a flat element having at least two opposite ends and adapted to be connected to at least one of the damaged tendons of the rotator cuff of a patient at the ends; the flat element being entirely made of biodegradable and resorbable material.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: December 17, 2019
    Inventor: Antonio Sambusseti
  • Patent number: 10500031
    Abstract: An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. Each mesh extension is configured to permit multiple anchor points with surrounding tissue upon implantation. In one embodiment, a fixation device is at the second end of each mesh extension. Methods of using the implantable mesh are also provided.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 10, 2019
    Assignee: Duke University
    Inventor: Howard Levinson
  • Patent number: 10493180
    Abstract: Disclosed are composite implantable tissue attachment devices comprising a mechanical reinforcing component and a cellular scaffold component. Disclosed devices include a wide, relatively flat portion for supporting long term repair of tissue. Disclosed devices can include a tapered portion at the end of the wide portions that can lead into a narrower elongated extension for aiding in placement of the device during a surgical procedure. The wide portion of the device can provide tensile strength along the longitudinal axis of the device as well as porosity. The wide devices can cover a larger surface area of a delivery site than standard suture. Disclosed materials can be utilized in, e.g., soft tissue repair such as tendon and ligament reconstruction and repair.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: December 3, 2019
    Inventors: John Eric Brunelle, Al Weinstein
  • Patent number: 10478281
    Abstract: An implantable prosthesis for mending anatomical defects, including a groin hernia. The prosthesis includes a prosthetic repair patch that may be implanted in different tissue planes to mend a defect. The patch may include a medial portion configured to be positioned in a first tissue plane and a lateral portion configured to be positioned in a second tissue plane offset from the first tissue plane. The patch may include a transition region configured to extend through tissue and/or muscle, such as fascia, separating the tissue planes and transition the patch from one tissue plane to the other tissue plane. The transition region may be configured to inhibit buckling and/or bunching of the patch when implanted through the fascia. The lateral portion of the patch may have a level of stiffness that facilitates implantation of the patch in different tissue planes while inhibiting patient sensation to the implanted patch.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: November 19, 2019
    Assignee: C.R. Bard, Inc.
    Inventors: Melissa Bowley, Devang Vijay Shah, Philip A. Tessier
  • Patent number: 10478188
    Abstract: A staple cartridge assembly is disclosed which comprises a cartridge body and an implantable layer. The implantable layer includes fibers comprised of a first material and a second material. The first material and the second material have different glass transition temperatures. After the fibers comprised of the first material and the second material have been intermixed or interwoven, the layer is exposed to a temperature which exceeds the lower of the two glass transition temperatures. This heating process causes the layer to constrict and increase in thickness. The layer, when implanted, can compensate for variations in tissue thickness within the staples.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 19, 2019
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Frederick E. Shelton, IV, Michael J. Vendely, Susanne Landgrebe
  • Patent number: 10470887
    Abstract: Herein disclosed is a tissue supplied in a configuration pre-shaped to the topography of the recipient surface for covering defects in the articulating surfaces of bones. Also discussed herein is a method of preparing a graft for reconstruction of a defect in an articular surface of a bone comprising determining the topography of the native articular surface and the corresponding underside of the cartilage layer; fabricating a pair of mating surfaces having the topography of the native articular surface and the underside of the cartilage layer; harvesting a cartilage graft from a cadaveric donor; and placing said graft between the mating surfaces and subjecting said graft to sufficient pressure for a sufficient duration to cause it to change shape to that of the deforming surfaces.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: November 12, 2019
    Assignee: Institute of Orthopedic Research & Education
    Inventors: Hugh Jones, Philip C. Noble
  • Patent number: 10456131
    Abstract: An implant insertion device is adapted for use with a shape memory implant. The shape memory implant includes a bridge interconnecting first and second legs. The shape memory implant is movable between a first shape in which the first and second legs are substantially non-parallel and a second shape in which the first and second legs are substantially parallel. The implant insertion device engages the shape memory implant to maintain the shape memory implant in its second shape until the delivery of the shape memory implant into tissue or bone.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: October 29, 2019
    Assignee: BioMedical Enterprises, Inc.
    Inventors: Daniel F. Cheney, Joseph H. Taber, Luke A. Perkins, Joseph P. Ritz
  • Patent number: 10426586
    Abstract: A sacrocolpopexy support has a head section extending from a first end portion to a second end portion, and a leg section having a first leg portion placed on and in longitudinal alignment with a second leg portion. A first connector secures the leg section to the second end portion of the head section. A second connector secures the first leg portion to the second leg portion to form a closed joint that defines a space between the first leg portion and the second leg portion. An end of the second end portion of the head section terminates at a location exterior to the closed joint outside of the space between the first leg portion and the second leg portion.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 1, 2019
    Assignee: Coloplast A/S
    Inventors: Sarah J. Deitch, Michael M. Witzmann, John J. Allen, David Richmond, Matthew George Litton
  • Patent number: 10400217
    Abstract: The present invention relates to an immortalized cell, an immortalized cell line comprising said immortalized cell, a cell culture comprising the immortalized cell or cell line, and a method for the production of an immortalized cell.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 3, 2019
    Inventor: Dorothea Alexander-Friedrich
  • Patent number: 10390946
    Abstract: A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: August 27, 2019
    Assignee: Biotronik AG
    Inventors: Nina Lehenberger, Alexander Rzany, Wilhelm Erdbruegger
  • Patent number: 10335516
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 2, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10314783
    Abstract: The present invention relates to articles and methods of treating vascular conditions with a thixotropic, turbid, bioactive agent-containing gel material capable of being essentially removed from an implantation site upon re-establishment of fluid flow at the implantation site.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: June 11, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Paul D. Drumheller, Theresa A. Holland
  • Patent number: 10314688
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: June 11, 2019
    Assignee: Arthrex, Inc.
    Inventors: David Shepard, Reinhold Schmeiding, Adam Anz, Steve Jordan, John Tokish
  • Patent number: 10285699
    Abstract: A compressible adjunct has a first portion, a second portion, and a middle portion. The middle portion is disposed between the first portion and the second portion. The middle portion comprises a first pillar, a second pillar, and an interconnecting member. The first pillar and the second pillar extend substantially between the first portion and the second portion. The interconnecting member is configured to engage at least the first pillar and the second pillar. When the compressible adjunct is compressed by a force, the first pillar is configured to deflect a first deflection and the second pillar is configured to deflect a second deflection. The first deflection differs from the second deflection.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 14, 2019
    Assignee: Ethicon LLC
    Inventors: Michael J. Vendely, Frederick E. Shelton, IV, Jason L. Harris, Howell T. Goldrein, Robert S. Moir, Sofia Maria Consonni, Ismail Akram, Ashley D. Easter, Helen S. Latham
  • Patent number: 10271942
    Abstract: The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 30, 2019
    Assignee: Arthrex, Inc.
    Inventors: John Tokish, David Shepard, Brian Dorn
  • Patent number: 10258504
    Abstract: A method of repairing a detached retina includes removing sub-retinal fluid from a location within the eye between the retinal tissue and an underlying support tissue, inserting a biocompatible elastomeric patch having encapsulated ferromagnetic particles into an interior of the eye through an incision of a sclera of the eye, positioning a magnetic source adjacent to an exterior surface of the eye such that the magnetic source is aligned with the detached retinal tissue, and drawing the removable elastomeric patch toward the detached portion of the retina with the magnetic source such that the detached retinal tissue is substantially maintained against underlying support tissue along an inner eye wall by magnetic attraction between the encapsulated magnetic particles of the removable elastomeric patch and the magnetic source.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 16, 2019
    Inventor: Richard Breazeale