Having Micro Particles Patents (Class 623/23.73)
  • Patent number: 10632230
    Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth, the implant comprising: a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and an oxysterol in an amount of about 20 wt % to about 90 wt % of the implant. The implant has a high oxysterol load. Methods of making and use are further provided.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: April 28, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 10220058
    Abstract: The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: March 5, 2019
    Assignee: Vivex Biomedical, Inc.
    Inventor: Harry Thomas Temple
  • Patent number: 10111988
    Abstract: A porous three-dimensional structure of polytetrafluoroethylene was created featuring an enhanced ability of soft tissue ingrowth, or, in the second embodiment, combining the properties of an enhanced ability of soft tissue ingrowth with a barrier for the deposition of the living tissue cells. In the first embodiment of the porous three-dimensional structure of polytetrafluoroethylene it contains the open through pores and the blind pores, uniformly distributed over the inner surfaces of the open pores and connected therewith, and is made of mixture of the free-flow polytetrafluoroethylene having the granules sized from 100 to 300 microns, and the constraint-flow polytetrafluoroethylene having the granules sized up to 20 microns. In the second embodiment of the porous three-dimensional structure at least one surface of the three-dimensional body is provided with a barrier layer.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: October 30, 2018
    Inventor: Anatoli D. Dosta
  • Patent number: 10111908
    Abstract: The present invention provides a novel way to replenish the disc using retooled disc compositions to repair degenerative discs. There is no better source of proteoglycans than the actual disc material (6) itself. To this end, there has been developed a technique to remove the nucleus pulposus and retool the morphology of the nucleus pulposus to create a powder material (10) that is dry and can be stored at room temperature for long periods of time. This powder (10) can then be reconstituted with a variety of fluids, the most suitable being normal saline or lactated ringers to form a flowable mixture (20).
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: October 30, 2018
    Assignee: Vivex Biomedical, Inc.
    Inventor: Harry Thomas Temple
  • Patent number: 9579348
    Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: February 28, 2017
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Charito S. Buensuceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
  • Patent number: 8945600
    Abstract: Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: February 3, 2015
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventor: Benjamin S. Bleier
  • Patent number: 8882850
    Abstract: A collagenous biomaterial medical device comprising a molded sponge material formed from comminuted submucosa fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, and wherein said biotropic agent is a growth factor is disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 11, 2014
    Assignee: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Umesh H. Patel
  • Publication number: 20140200678
    Abstract: Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 17, 2014
    Applicant: THE UNIVERSITY OF KANSAS
    Inventors: Michael Detamore, Vineet Gupta, Neethu Mohan, Cory Berkland
  • Patent number: 8734527
    Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: May 27, 2014
    Assignee: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: Charito S. Buensuceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
  • Patent number: 8715366
    Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: May 6, 2014
    Assignee: Globus Medical, Inc.
    Inventor: Mark Borden
  • Patent number: 8673338
    Abstract: Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 18, 2014
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventor: Benjamin S. Bleier
  • Publication number: 20140052274
    Abstract: Described herein are tissue grafts composed of at least one membrane, where at least one side of the membrane has micronized placental tissue applied it. Also described herein are methods for making and using the tissue grafts.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 20, 2014
    Applicant: MiMedx Group, Inc.
    Inventor: MiMedx Group, Inc.
  • Patent number: 8623446
    Abstract: The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: January 7, 2014
    Assignee: Metascape LLC
    Inventors: Terrence S. McGrath, Deidre Sewell, Daniel M. Storey
  • Patent number: 8614189
    Abstract: The present invention provides biocompatible composite materials that can be fabricated into a scaffold having properties suitable for bone repair and regeneration. These scaffolds have sufficient mechanical strength to be useful for the repair and regeneration of cortical bone.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: December 24, 2013
    Assignee: University of Connecticut
    Inventors: Cato T. Laurencin, Syam Prasad Nukavarapu, Sangamesh G. Kumbar
  • Publication number: 20130338792
    Abstract: Techniques, mixtures, mixing and delivery kits, and improved delivery instruments for implantation of micronized allograft tissue over a microfractured defect. Allograft cartilage tissue is delivered over a cartilage defect that has been debrided and microfractured, without the need for a periosteal covering or separate type of patch sewn over the top. The allograft tissue may be any micronized cartilage particulates obtained by various methods, for example, cartilage delivered in its native form, dehydrated via lyophilization, “freeze-dried,” dehydrated via desiccation, or dehydrated by any other method.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 19, 2013
    Inventors: Reinhold Schmieding, Brandon L. Roller, David O. Shepard, G. Joshua Karnes, Robert Benedict, Tithi Dutta Roy, Brian J. Cole, James P. Bradley, Eric Giza, James L. Cook, Lisa A. Fortier
  • Publication number: 20130325144
    Abstract: The present invention concerns a biomaterial comprising a nanofibrous scaffold made of polymers, such as poly(?-caprolactone) or collagen, coated with at least one layer pair consisting of a layer of polyanions and a layer of polycations, wherein said at least one layer pair incorporates a therapeutic molecule such as a growth factor. The biomaterial may optionally comprise living cells such as osteoblasts and/or chondrocytes.
    Type: Application
    Filed: February 22, 2012
    Publication date: December 5, 2013
    Applicant: UNIVERSITÉ DE STRASBOURG
    Inventors: Nadia Benkirane-Jessel, Didier Mainard, Carlos Mendoza Palomares
  • Patent number: 8597745
    Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: December 3, 2013
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
  • Patent number: 8535388
    Abstract: The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: September 17, 2013
    Inventor: Timothy Ganey
  • Patent number: 8517028
    Abstract: A patient's obstructive sleep apnea is treated by placing a fibrosis-inducing agent is placed within the tongue in a region extending substantially from a hyoid bone rearward toward a back surface of the tongue and upwardly along the back wall toward a free end of a soft palate of the patient.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: August 27, 2013
    Assignee: Medtronic Xomed, Inc.
    Inventor: Paul J. Buscemi
  • Patent number: 8480758
    Abstract: An assembly for fixating a prosthesis in body tissue such as bone of a mammal, comprising a mechanical compacting device and a mass comprising at least granules of a biocompatible material having a sponge-like structure, wherein the mechanical compacting device is designed for compacting the granules during use by insertion of the device in a hole in bone and subsequently inducing relative movement of at least a first part of the compacting device relative to a second part thereof, such that the volume of at least one space between at least part of an outer surface of the device and the adjacent inner surface of said hole is reduced.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: July 9, 2013
    Assignee: Fondel Finance, B.V.
    Inventor: Daniel John Donald McLeod
  • Patent number: 8268010
    Abstract: A method for treating a vertebral bone comprises providing a plurality of hollow microparticles and providing a flowable and settable bone filling material. The method further comprises mixing the plurality of hollow microparticles with the bone filling material to form a bone augmentation material. The method further comprises inserting an injection device into the vertebral bone and injecting the bone augmentation material from the injection device and into the vertebral bone.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: September 18, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Hai H. Trieu, Aashiish Agnihotri, Joseph Saladino
  • Patent number: 8211085
    Abstract: Therapeutic device intended for the selective cytoreductive treatment of an obstruction in a natural lumen or passage of the human or animal body, said lumen being obstructed by the effect of a local cell proliferation, said device comprising a tubular element, in particular of cylindrical shape, intended to be placed in said natural lumen and sufficiently flexible to conform to said natural lumen, but sufficiently rigid to maintain an artificial channel in said lumen. The tubular element supports lengthwise a medicinal sleeve which is intended to come into line with, and into contact with, the obstruction once the natural lumen has been intubated, and is designed to deliver locally, at least in its outer surface portion, at least one therapeutic agent which is cytoreductive, in particular cytotoxic, through contact with the cells under whose effect said lumen is obstructed.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: July 3, 2012
    Inventor: Marian Devonec
  • Patent number: 8163031
    Abstract: A system and method for treating bone abnormalities including vertebral compression fractures and the like. In one method, an elastomeric composite implant body is inserted into bone. A rigid insert can be inserted into the elastomeric composite implant body. The elastomeric composite implant body can be deformed with the rigid insert to thereby form an interference fit between the bone and the implant.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: April 24, 2012
    Assignee: DFINE, Inc.
    Inventors: Csaba Truckai, John H. Shadduck
  • Patent number: 8127770
    Abstract: A method of treating a ligament or tendon according to the present invention can include inserting a tissue-generating implant into the ligament or tendon to thereby treat the defect. The tissue-generating implant has a plurality of microparticles. The microparticles subsequently form a biological scaffold which operates at least as partial connective tissue in the ligament or tendon giving structural support during regrowth.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: March 6, 2012
    Assignee: SpineOvations, Inc.
    Inventors: Neville Alleyne, Stuart Young
  • Patent number: 8110007
    Abstract: Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: February 7, 2012
    Assignee: Globus Medical, Inc
    Inventor: Mark Borden
  • Patent number: 8067071
    Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: November 29, 2011
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
  • Publication number: 20110288656
    Abstract: A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.
    Type: Application
    Filed: August 1, 2011
    Publication date: November 24, 2011
    Inventors: Bradley Kropp, Hsueh-Kung Lin, Fadee Mandelek, Brian P. Grady
  • Patent number: 8048500
    Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: November 1, 2011
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Paul D. Drumheller, Ted R. Farnsworth, Charles Flynn, Byron K. Hayes, Charles F. White
  • Patent number: 8048503
    Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: November 1, 2011
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
  • Patent number: 8029575
    Abstract: Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: October 4, 2011
    Assignee: Globus Medical, Inc.
    Inventor: Mark Borden
  • Patent number: 8002845
    Abstract: The subject invention provides materials and methods for soft tissue augmentation. The materials and methods of the subject invention can, advantageously, be used to correct defects such as velopharyngeal insufficiency after cleft palate repair. Other uses include treatments for gastroesophageal acid-reflux, urinary incontinence, wrinkles and contour abnormalities.
    Type: Grant
    Filed: November 15, 2009
    Date of Patent: August 23, 2011
    Inventor: Leonard T. Furlow, Jr.
  • Patent number: 7993412
    Abstract: Nanomaterials for neural and orthopedic prostheses are disclosed. Composite carbon nanofibers enhance neuronal growth and minimize glial scar tissue formation. Methods and compositions to promote neuronal growth and minimize scar tissue formation during prolonged monitoring and treatment of neural tissue are disclosed. Composite polyurethane carbon nanofiber is a suitable material for neural implant. Composite carbon nanomaterials decrease adhesion of astrocytes and fibroblasts.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: August 9, 2011
    Assignee: Purdue Research Foundation
    Inventors: Thomas J. Webster, Janice L. McKenzie
  • Patent number: 7985263
    Abstract: An improved, polymeric surgical membrane, which can be used in a variety of surgical procedures, such as sutured and sutureless duraplasty procedures. For sutureless applications, a textured, discontinuous, outer polymer layer is provided which encourages rapid incorporation and anchoring into surrounding tissue. In cooperation with the discontinuous first layer, a second elastomeric layer provides elasticity and resilience. A third barrier layer is provided to essentially eliminate adhesions and irritation to surrounding tissue. In those applications requiring anchoring sutures, the second elastomeric layer “self-seals” against the sutures, essentially eliminating the leakage of blood, cerebrospinal fluid, or other fluids. In addition, the composite structure of the present invention has a high degree of suture retention strength is polymeric with a high degree of biocompatibility, is thin and very flexible.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: July 26, 2011
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Andrew B. Berman, Thane L. Kranzer, Dean R. Wentworth
  • Patent number: 7901770
    Abstract: Embolic compositions and methods of delivering the compositions are disclosed. In some embodiments, the embolic compositions include a shape memory material.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: March 8, 2011
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Paul DiCarlo, Robert F. Rioux, James Tobin, Barbara Bell, Thomas V. Casey, II, William J. Shaw
  • Patent number: 7887843
    Abstract: The invention relates to a remarkably simple method for the in vitro production of three-dimensional, vital and mechanically stable cartilage or bone tissue and to the use thereof as a transplantation material for treating cartilage or bone defects and degenerative diseases such as rheumatism or arthrosis, and to the use thereof in testing active substances and physical factors. The invention is also directed to the cartilage or bone tissue and therapeutical formulations produced thereby, e.g. injection solutions comprising such tissue.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: February 15, 2011
    Assignee: Co.don Aktiengesllschaft
    Inventors: Jeanette Libera, Ursula Anderer, Karl-Gerd Fritsch, Olivera Josimovic-Alasevic
  • Patent number: 7887599
    Abstract: This invention is directed to the field of medical implants, and more specifically to biodegradable injectable implants and their methods of manufacture and use. The injectable implants disclosed herein comprise glycolic acid and bio-compatible/bio-absorbable polymeric particles containing a polymer of lactic acid. The particles are small enough to be injected through a needle but large enough to avoid engulfment by macrophages. The injectables of this invention may be in a pre-activated solid form or an activated form (e.g., injectable suspension or emulsion).
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: February 15, 2011
    Inventors: Crisoforo Peralta Casares, Daniel Leon de Lagarde
  • Publication number: 20100179667
    Abstract: A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold.
    Type: Application
    Filed: January 15, 2009
    Publication date: July 15, 2010
    Applicant: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Steven B. Jung
  • Publication number: 20100076556
    Abstract: In-vivo biodegradable medical implants, containing at least in part at least partially fine-grained metallic materials that are strong, tough, stiff and lightweight, are disclosed The in-vivo biodegradable implants are used in a number of stent applications, for fracture fixation, sutures and the like.
    Type: Application
    Filed: September 24, 2008
    Publication date: March 25, 2010
    Applicant: Intergran technologies, Inc.
    Inventors: Klaus Tomantschger, Gino Palumbo, Diana Facchini
  • Patent number: 7655048
    Abstract: The subject invention provides materials and methods for soft tissue augmentation. The materials and methods of the subject invention can, advantageously, be used to correct defects such as velopharyngeal insufficiency after cleft palate repair. Other uses include treatments for gastroesophageal acid-reflux, urinary incontinence, wrinkles and contains abnormalities.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 2, 2010
    Inventor: Leonard T. Furlow, Jr.
  • Patent number: 7641958
    Abstract: An improved, polymeric surgical membrane, which can be used in a variety of surgical procedures, such as sutured and sutureless duraplasty procedures. For sutureless applications, a textured, discontinuous, outer polymer layer is provided which encourages rapid incorporation and anchoring into surrounding tissue. In cooperation with the discontinuous first layer, a second elastomeric layer provides elasticity and resilience. A third barrier layer is provided to essentially eliminate adhesions and irritation to surrounding tissue. In those applications requiring anchoring sutures, the second elastomeric layer “self-seals” against the sutures, essentially eliminating the leakage of blood, cerebrospinal fluid, or other fluids. In addition, the composite structure of the present invention has a high degree of suture retention strength is polymeric with a high degree of biocompatibility, is thin and very flexible.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: January 5, 2010
    Assignee: Gore Enterprise Holdings, Inc.
    Inventors: Andrew B. Berman, Thane L. Kranzer, Dean R. Wentworth
  • Publication number: 20090319045
    Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.
    Type: Application
    Filed: March 5, 2009
    Publication date: December 24, 2009
    Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich, Alex B. Callahan, Judith I. Yannariello-Brown, Morris L. Jacobs, John C. Munson, Yen-Chen Huang
  • Patent number: 7588825
    Abstract: Embolic compositions and methods of delivering the compositions are disclosed. In some embodiments, an embolic composition includes a first collection of particles having a first shape, and a second collection of particles having a second shape different than the first shape.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: September 15, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Barbara Bell, Thomas V. Casey, II, William J. Shaw
  • Patent number: 7585319
    Abstract: An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: September 8, 2009
    Assignee: Maquet Cardiovascular, LLC
    Inventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
  • Patent number: 7585320
    Abstract: A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: September 8, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Mark A Hamm, Louis J Barbato, Robert J Crowley, Wendy Naimark, Hatal Patel
  • Publication number: 20090069815
    Abstract: The invention provides a method and a kit for administering bone cement to the interior cavity of a bony member to enhance bone strength, stabilizing an existing fracture thus reducing susceptibility of the bone to further fracture and/or collapse. The method and kit may include additional components, such as, bone growth enhancing agents, radiopaque components or the like.
    Type: Application
    Filed: September 12, 2007
    Publication date: March 12, 2009
    Inventor: Jeffrey C. Fernyhough
  • Patent number: 7491243
    Abstract: The present invention provides a method of modifying the lower esophagus by injecting biocompatible particles in a biocompatible carrier into a submucosal tissue site of the lower esophagus of a patient. The method may be used to treat gastroesophageal reflux disease by optimizing the closing function of the lower esophageal sphincter.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: February 17, 2009
    Assignee: Carbon Medical Technologies
    Inventor: Dean A. Klein
  • Publication number: 20090024229
    Abstract: The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 22, 2009
    Inventors: Silvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, JR., Mark Moore, Rony Thomas, Alyce Linthurst Jones
  • Publication number: 20080172131
    Abstract: A method for treating a vertebral bone comprises providing a plurality of hollow microparticles and providing a flowable and settable bone filling material. The method further comprises mixing the plurality of hollow microparticles with the bone filling material to form a bone augmentation material. The method further comprises inserting an injection device into the vertebral bone and injecting the bone augmentation material from the injection device and into the vertebral bone.
    Type: Application
    Filed: January 12, 2007
    Publication date: July 17, 2008
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Hai H. Trieu, Aashiish Agnihotri, Joseph Saladino
  • Publication number: 20080154386
    Abstract: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
    Type: Application
    Filed: December 5, 2007
    Publication date: June 26, 2008
    Inventors: John W. Morris, Lawrence A. Shimp, Kenneth C. Petersen, Albert Manrique, David Kaes, Nelson Scarborough, Michael Dowd
  • Publication number: 20080107744
    Abstract: The present invention comprises a plurality of injectable hollow particulate fillers suspended in a biocompatible fluid carrier to significantly improve the clumping resistance and injectability of the composition. The hollow particulate fillers have a lower effective density and are able to suspend in the carrier without precipitation. The loss of skin volume as a result of aging, diseases, weight loss, and injury can lead to uneven skin surface (e.g. wrinkle, etc.). The uneven skin can be repaired by injecting appropriate amount of hollow fillers underneath the skin. Some cases of urinary incontinence occur when the resistance to urine flow has decreased excessively. Continence is restored by injecting the present invention to the urethra tissue to increase resistance to urine outflow. Similarly, the present invention allows for the control of gastric fluid reflux by submucosal injections of the fillers to the esophageal-gastric and gastric-pyloric junction.
    Type: Application
    Filed: November 5, 2007
    Publication date: May 8, 2008
    Inventor: Jack Fa-De Chu